Pub Date : 2026-01-14DOI: 10.1213/ane.0000000000007940
Morgan L Brown,David Whiting,James A DiNardo,Viviane G Nasr
{"title":"Institutional Experience Introducing Portable Capnography Intrahospital Transport of Ventilated Patients With Congenital Heart Disease.","authors":"Morgan L Brown,David Whiting,James A DiNardo,Viviane G Nasr","doi":"10.1213/ane.0000000000007940","DOIUrl":"https://doi.org/10.1213/ane.0000000000007940","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1213/ane.0000000000007907
Muge Qile,Zhaofei Luo,Chao Wu,Xueying Cheng,Yu Zhang,Liu Liu,Qingtong Wang,Ye Zhang,Eric R Gross,Shufang He
BACKGROUNDMyocardial ischemia/reperfusion (I/R) injury commonly occurs in patients undergoing cardiac or noncardiac surgeries, increasing perioperative mortality risk. Although numerous endogenous mediators released during I/R contribute to myocardial damage, their mechanisms require further elucidation. We investigated whether lysophosphatidic acid (LPA), a bioactive phospholipid, mediates myocardial I/R injury by interacting with cardiac transient receptor potential vanilloid 1 (TRPV1).METHODSA TRPV1K710N knock-in mouse model was generated by CRISPR/Cas9, introducing a point mutation at K710, the known LPA-binding site on TRPV1. Langendorff perfused isolated hearts from TRPV1K710N and wild-type (WT) mice underwent global I/R injury with or without exogenous LPA (10 μM). Myocardial infarct size, coronary effluent LDH levels, and mitochondrial ultrastructure/function were assessed. Additionally, H9c2 cardiomyocytes were transfected with a pCMV6-entry plasmid carrying TRPV1-K710N or TRPV1-WT for mitochondrial calcium influx and cell viability assays. The V1-Cal peptide (1μM), targeting the K710 region, was applied ex vivo and in vitro to block LPA-TRPV1 interaction.RESULTSTRPV1K710N hearts exhibited resistance to global I/R injury versus WT hearts, with reduced infarct size (28.3 ± 2.4% vs 39.9 ±2.3%, respectively, P= 0006), lower LDH levels, and attenuated mitochondrial damage. Exogenous LPA exacerbated I/R injury in WT hearts, increasing infarct size (63.7 ± 1.2% vs vehicle: 38.4 ± 2.4%; P <.0001), LDH release, and mitochondrial damage. TRPV1K710N hearts were resistant to LPA-induced injury, with no significant increase in infarct size after LPA treatment. Exogenous LPA induced pronounced swelling in mitochondria isolated from WT hearts, while mitochondria from TRPV1K710N hearts showed resistance to LPA challenge. In H9c2 cells, LPA significantly decreased viability in rTRPV1-WT cells and elevated mitochondrial calcium influx relative to rTRPV1-K710N cells. V1-Cal peptide attenuated LPA-mediated myocardial injury in WT hearts and reduced mitochondrial calcium overload in H9c2 cells.CONCLUSIONSBlockade of the TRPV1 K710 site by K710N mutation or V1-Cal peptide mitigates LPA-mediated myocardial injury and mitochondrial damage/dysfunction in isolated mouse hearts. Targeting the cardiac LPA-TRPV1 interaction represents a promising therapeutic strategy against perioperative myocardial injury.
{"title":"Site-Specific Blockade of LPA-TRPV1 Interaction at K710 Residue Influences on Myocardial Ischemia/Reperfusion Injury in Ex Vivo Mouse Hearts.","authors":"Muge Qile,Zhaofei Luo,Chao Wu,Xueying Cheng,Yu Zhang,Liu Liu,Qingtong Wang,Ye Zhang,Eric R Gross,Shufang He","doi":"10.1213/ane.0000000000007907","DOIUrl":"https://doi.org/10.1213/ane.0000000000007907","url":null,"abstract":"BACKGROUNDMyocardial ischemia/reperfusion (I/R) injury commonly occurs in patients undergoing cardiac or noncardiac surgeries, increasing perioperative mortality risk. Although numerous endogenous mediators released during I/R contribute to myocardial damage, their mechanisms require further elucidation. We investigated whether lysophosphatidic acid (LPA), a bioactive phospholipid, mediates myocardial I/R injury by interacting with cardiac transient receptor potential vanilloid 1 (TRPV1).METHODSA TRPV1K710N knock-in mouse model was generated by CRISPR/Cas9, introducing a point mutation at K710, the known LPA-binding site on TRPV1. Langendorff perfused isolated hearts from TRPV1K710N and wild-type (WT) mice underwent global I/R injury with or without exogenous LPA (10 μM). Myocardial infarct size, coronary effluent LDH levels, and mitochondrial ultrastructure/function were assessed. Additionally, H9c2 cardiomyocytes were transfected with a pCMV6-entry plasmid carrying TRPV1-K710N or TRPV1-WT for mitochondrial calcium influx and cell viability assays. The V1-Cal peptide (1μM), targeting the K710 region, was applied ex vivo and in vitro to block LPA-TRPV1 interaction.RESULTSTRPV1K710N hearts exhibited resistance to global I/R injury versus WT hearts, with reduced infarct size (28.3 ± 2.4% vs 39.9 ±2.3%, respectively, P= 0006), lower LDH levels, and attenuated mitochondrial damage. Exogenous LPA exacerbated I/R injury in WT hearts, increasing infarct size (63.7 ± 1.2% vs vehicle: 38.4 ± 2.4%; P <.0001), LDH release, and mitochondrial damage. TRPV1K710N hearts were resistant to LPA-induced injury, with no significant increase in infarct size after LPA treatment. Exogenous LPA induced pronounced swelling in mitochondria isolated from WT hearts, while mitochondria from TRPV1K710N hearts showed resistance to LPA challenge. In H9c2 cells, LPA significantly decreased viability in rTRPV1-WT cells and elevated mitochondrial calcium influx relative to rTRPV1-K710N cells. V1-Cal peptide attenuated LPA-mediated myocardial injury in WT hearts and reduced mitochondrial calcium overload in H9c2 cells.CONCLUSIONSBlockade of the TRPV1 K710 site by K710N mutation or V1-Cal peptide mitigates LPA-mediated myocardial injury and mitochondrial damage/dysfunction in isolated mouse hearts. Targeting the cardiac LPA-TRPV1 interaction represents a promising therapeutic strategy against perioperative myocardial injury.","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1213/ane.0000000000007902
Yangzi Zhu,Ying Wu,Kailun Gao,Yuning Sun,Junfeng Hu,Liwei Wang,Jun-Li Cao
BACKGROUNDThe surgical interventions aimed at fracture repair are often accompanied by chronic postsurgical pain (CPSP), which is associated with depression, impaired quality of life, and increased societal burden. This phenomenon is particularly understudied in young patients with distal lower extremity fracture. Developing a scalable and accurate predictive model could improve postoperative care by enabling early detection of high-risk patients and guiding personalized pain management strategies.METHODSThis study collected in-hospital medical records and conducted follow-up for all patients over a 1-year period. We developed a predictive model through a 3-stage approach involving Least Absolute Shrinkage and Selection Operator (LASSO) regression, information gain analysis, and multivariable logistic regression, followed by model validation. Using the Shinyapps.io platform to build a webpage risk calculator for the final prediction model.RESULTSThe final cohort included 818 patients: 38.4% of whom experienced CPSP, and 18.2% of patients with CPSP developed neuropathic pain. There are 6 independent variables associated with CPSP: postoperative analgesic technique, fixation type, preoperative clinical management, and numerical rating scale (NRS) score on the day of the visit and postoperative day 1. The optimism-corrected area under the receiver operating curve for the development cohort and validation cohort were 0.872 and 0.838, respectively, and this model demonstrated good calibration and clinical utility. A web-based predictive nomogram was established by integrating machine learning-based big data variable screening with the interpretability of traditional logistic regression.CONCLUSIONSThis study demonstrates that pain management strategies, surgical approaches, and patient psychological factors collectively influence the development of CPSP. By integrating machine learning-based big data variable screening with the interpretability of traditional logistic regression, we developed a web-based predictive nomogram capable of identifying early CPSP risk at hospital discharge, thereby improving accessibility to transitional pain care interventions.
{"title":"Risk Factors and Prediction of Chronic Postsurgical Pain Among Patients With Distal Lower Extremity Fracture: Cohort Analysis.","authors":"Yangzi Zhu,Ying Wu,Kailun Gao,Yuning Sun,Junfeng Hu,Liwei Wang,Jun-Li Cao","doi":"10.1213/ane.0000000000007902","DOIUrl":"https://doi.org/10.1213/ane.0000000000007902","url":null,"abstract":"BACKGROUNDThe surgical interventions aimed at fracture repair are often accompanied by chronic postsurgical pain (CPSP), which is associated with depression, impaired quality of life, and increased societal burden. This phenomenon is particularly understudied in young patients with distal lower extremity fracture. Developing a scalable and accurate predictive model could improve postoperative care by enabling early detection of high-risk patients and guiding personalized pain management strategies.METHODSThis study collected in-hospital medical records and conducted follow-up for all patients over a 1-year period. We developed a predictive model through a 3-stage approach involving Least Absolute Shrinkage and Selection Operator (LASSO) regression, information gain analysis, and multivariable logistic regression, followed by model validation. Using the Shinyapps.io platform to build a webpage risk calculator for the final prediction model.RESULTSThe final cohort included 818 patients: 38.4% of whom experienced CPSP, and 18.2% of patients with CPSP developed neuropathic pain. There are 6 independent variables associated with CPSP: postoperative analgesic technique, fixation type, preoperative clinical management, and numerical rating scale (NRS) score on the day of the visit and postoperative day 1. The optimism-corrected area under the receiver operating curve for the development cohort and validation cohort were 0.872 and 0.838, respectively, and this model demonstrated good calibration and clinical utility. A web-based predictive nomogram was established by integrating machine learning-based big data variable screening with the interpretability of traditional logistic regression.CONCLUSIONSThis study demonstrates that pain management strategies, surgical approaches, and patient psychological factors collectively influence the development of CPSP. By integrating machine learning-based big data variable screening with the interpretability of traditional logistic regression, we developed a web-based predictive nomogram capable of identifying early CPSP risk at hospital discharge, thereby improving accessibility to transitional pain care interventions.","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1213/ane.0000000000007896
Chen-Hwan Cherng
{"title":"LEMONS: Incorporating Stiffness of Submental/Submandibular Space into Difficult Airway Assessment.","authors":"Chen-Hwan Cherng","doi":"10.1213/ane.0000000000007896","DOIUrl":"https://doi.org/10.1213/ane.0000000000007896","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1213/ane.0000000000007903
Craig S Jabaley,Mark E Nunnally,Brigid C Flynn
{"title":"Medical Society Guideline Writing: The Why and How.","authors":"Craig S Jabaley,Mark E Nunnally,Brigid C Flynn","doi":"10.1213/ane.0000000000007903","DOIUrl":"https://doi.org/10.1213/ane.0000000000007903","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"390 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1213/ane.0000000000007935
Alexander Nagrebetsky,Girish P Joshi
{"title":"Prolonged Fasting and Patient-Centered Outcomes: When Science Meets Common Sense.","authors":"Alexander Nagrebetsky,Girish P Joshi","doi":"10.1213/ane.0000000000007935","DOIUrl":"https://doi.org/10.1213/ane.0000000000007935","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1213/ane.0000000000007932
Jean Charchaflieh,Avery Tung
{"title":"Does a Research Paper Always Need a Hypothesis?","authors":"Jean Charchaflieh,Avery Tung","doi":"10.1213/ane.0000000000007932","DOIUrl":"https://doi.org/10.1213/ane.0000000000007932","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"216 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1213/ane.0000000000007933
Micheal W Vespe,Ronald A Kahn
{"title":"Detecting Early Oxygenator Failure During Cardiopulmonary Bypass: An Evaluation of Uncalibrated Measurements of In-Line Po2.","authors":"Micheal W Vespe,Ronald A Kahn","doi":"10.1213/ane.0000000000007933","DOIUrl":"https://doi.org/10.1213/ane.0000000000007933","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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