Pub Date : 2025-11-20DOI: 10.1213/ane.0000000000007834
Arunabha Karmakar,Muhammad J Khan,Moncef B G B Saad
{"title":"Institutional Perspectives on Supraglottic Airway Use in Laparoscopic Surgery: The Role of Weighted Risk.","authors":"Arunabha Karmakar,Muhammad J Khan,Moncef B G B Saad","doi":"10.1213/ane.0000000000007834","DOIUrl":"https://doi.org/10.1213/ane.0000000000007834","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDThis study investigates the role and mechanism of neutrophil extracellular trap (NET) clearance by aged macrophages during sepsis-induced liver injury, as elderly patients show higher rates of organ damage and mortality in sepsis.METHODSA sepsis model was established using cecal ligation and puncture (CLP) in aged (100-week-old) and young mice (8-week-old) to study NET clearance by macrophages, assessing liver injury and inflammatory responses with interventions targeting AMP-dependent protein kinase (AMPK) and phagocytosis pathways. Additionally, the study included 40 sepsis patients, with 25 elderly (65-89 years) and 15 young (31-62 years) individuals, and collected peripheral blood samples from all for in vitro experiments.RESULTSIn aged mice, a significant increase in 7-day mortality was observed (hazard ratio [HR] = 2.50, 95% confidence interval [CI], 1.10-5.65, P = .009), alongside heightened inflammatory response and liver injury (histopathology score: 3.2 ± 0.4 vs 2.4 ± 0.6; P = .021), compared to young mice post-CLP. Hepatic NET accumulation markedly increased (mean difference [MD] = 0.43%, 95% CI, 0.25%-0.61%; P < .001), which was attenuated by DNase I-mediated NET inhibition, reducing hepatic enzymes and inflammatory responses. Consistently, transplantation of young bone marrow into aged recipients significantly reduced NET accumulation (MD = -0.33%, 95% CI, -0.43% to -0.22%; P < .001). Mechanistically, the phosphorylation of AMPK (0.68-fold vs young; P < .001) and Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) was suppressed in aged septic mice. Activation of AMPK via 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) led to a decrease in hepatic NET accumulation (MD = -0.30%, 95% CI, -0.41% to -0.19%; P < .001), improved liver injury (histopathology score: 2.49 ± 0.24 vs 3.07 ± 0.28; P = .006), and reduced 7-day mortality (HR = 0.37, 95% CI, 0.15-0.94, P = .038). Critically, elderly patients exhibited elevated NET-related markers, compounded by suppressed AMPK phosphorylation and impaired NET phagocytosis (MD = -16.34%, 95% CI, -24.31% to -8.37%; P = .002).CONCLUSIONSAging impairs AMPK-mediated macrophage clearance of NETs in the liver, exacerbating liver inflammatory injury. Focusing on NETs could offer a therapeutic strategy to mitigate liver damage and reduce mortality in elderly sepsis patients.
{"title":"Impaired AMP-Dependent Protein Kinase-Mediated Neutrophil Extracellular Trap Clearance by Aged Macrophages in Sepsis-Induced Liver Injury.","authors":"Zhu Guan,Yan Bai,Xingyue Ji,Fei Li,Bo Zhou,Weizhe Zhong,Haoming Zhou,Zhuqing Rao","doi":"10.1213/ane.0000000000007831","DOIUrl":"https://doi.org/10.1213/ane.0000000000007831","url":null,"abstract":"BACKGROUNDThis study investigates the role and mechanism of neutrophil extracellular trap (NET) clearance by aged macrophages during sepsis-induced liver injury, as elderly patients show higher rates of organ damage and mortality in sepsis.METHODSA sepsis model was established using cecal ligation and puncture (CLP) in aged (100-week-old) and young mice (8-week-old) to study NET clearance by macrophages, assessing liver injury and inflammatory responses with interventions targeting AMP-dependent protein kinase (AMPK) and phagocytosis pathways. Additionally, the study included 40 sepsis patients, with 25 elderly (65-89 years) and 15 young (31-62 years) individuals, and collected peripheral blood samples from all for in vitro experiments.RESULTSIn aged mice, a significant increase in 7-day mortality was observed (hazard ratio [HR] = 2.50, 95% confidence interval [CI], 1.10-5.65, P = .009), alongside heightened inflammatory response and liver injury (histopathology score: 3.2 ± 0.4 vs 2.4 ± 0.6; P = .021), compared to young mice post-CLP. Hepatic NET accumulation markedly increased (mean difference [MD] = 0.43%, 95% CI, 0.25%-0.61%; P < .001), which was attenuated by DNase I-mediated NET inhibition, reducing hepatic enzymes and inflammatory responses. Consistently, transplantation of young bone marrow into aged recipients significantly reduced NET accumulation (MD = -0.33%, 95% CI, -0.43% to -0.22%; P < .001). Mechanistically, the phosphorylation of AMPK (0.68-fold vs young; P < .001) and Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) was suppressed in aged septic mice. Activation of AMPK via 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) led to a decrease in hepatic NET accumulation (MD = -0.30%, 95% CI, -0.41% to -0.19%; P < .001), improved liver injury (histopathology score: 2.49 ± 0.24 vs 3.07 ± 0.28; P = .006), and reduced 7-day mortality (HR = 0.37, 95% CI, 0.15-0.94, P = .038). Critically, elderly patients exhibited elevated NET-related markers, compounded by suppressed AMPK phosphorylation and impaired NET phagocytosis (MD = -16.34%, 95% CI, -24.31% to -8.37%; P = .002).CONCLUSIONSAging impairs AMPK-mediated macrophage clearance of NETs in the liver, exacerbating liver inflammatory injury. Focusing on NETs could offer a therapeutic strategy to mitigate liver damage and reduce mortality in elderly sepsis patients.","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1213/ane.0000000000007777
Maria C Gadella,Marko M Sahinovic,Sebastiaan E Dulfer,Katalin Tamási,Fiete Lange,Cristopher Faber,Frits Hein Wapstra,Rob J M Groen,Anthony R Absalom,Gea Drost
BACKGROUNDIntraoperative neurophysiological monitoring is used to assess neurological function during surgeries placing the spinal cord at risk. Transcranial electrical stimulation muscle motor evoked potentials (Tc-mMEPs) are used to monitor motors tracts, but their interpretation is complicated by the large temporal variability which can result in false-positive warnings. Although the choice of anesthetic drug regimen and drug dose are often claimed to be factors causing this variability, the relationship between depth of anesthesia, quantified by processed electroencephalogram (pEEG) parameters, and Tc-mMEPs characteristics in upper and lower extremity muscles have not yet been rigorously investigated in patients receiving propofol/remifentanil-based anesthesia.METHODSTwenty-five patients were included in this prospective observational study. All received propofol/remifentanil-based total intravenous anesthesia. Depth of anesthesia was quantified by the bispectral index (BIS). After induction of anesthesia, the target propofol concentration was altered to sequentially achieve BIS values of either 30, 40, and 50, or the reverse (direction randomly determined). At each depth of anesthesia Tc-mMEP thresholds were determined, and arterial blood samples were collected. Supramaximal Tc-mMEP signals were recorded every 2 minutes and amplitudes, latencies and area under the curve (AUC) were subsequently calculated. Effects of depth of anesthesia on Tc-mMEP outcomes were analyzed using linear mixed effects modeling.RESULTSThe median (range) age of the study population was 18 (14-66) years (n = 25). In the leg muscles, a decrease of 10 BIS points was associated with a decrease in Tc-mMEP amplitude of 11%-12% (all P < .001; mean [95% confidence interval {CI}], 12% [7.1-16], 11% [6.8-16], and 12% [7.5-16], for the AH, TA, and GAS muscles, respectively). In contrast, no significant amplitude or AUC change was found in the hand muscles (P = .201, 2.8% [-1.5 to 7.1] and P = .076, 4.0% [-0.4 to 7.6], respectively). Latencies changed <0.5% per 10 BIS points decrease (0.03% [-0.3 to 0.2], -0.2% [-0.5 to 0.1], -0.2% [-0.5 to 0.04], 0.3% [0.04-0.6] for the AH, TA, GAS, and hand muscles, respectively), and thresholds increased 3.6% (0.8-7) when BIS decreased from 50 to 30 (P = .037).CONCLUSIONSOur findings challenge some commonly held beliefs. First, our findings suggest that deeper anesthesia has differential effects on the different muscle groups, with little effect on the hand muscles. The current practice of using the hand signals as reference values during procedures below C8/T1 may therefore need re-evaluation. Second, the paucity of effect of depth of anesthesia on Tc-mMEP thresholds and latencies suggests that Tc-mMEP generation is not influenced by deep anesthesia in a clinically relevant way. Therefore, the threshold level monitoring method may provide a more reliable indicator of motor pathway integrity during surgery. This could reduce the likelihood o
{"title":"The Effects of Depth of Anesthesia on Muscle-Recorded Motor Evoked Potentials: A Prospective Observational Study.","authors":"Maria C Gadella,Marko M Sahinovic,Sebastiaan E Dulfer,Katalin Tamási,Fiete Lange,Cristopher Faber,Frits Hein Wapstra,Rob J M Groen,Anthony R Absalom,Gea Drost","doi":"10.1213/ane.0000000000007777","DOIUrl":"https://doi.org/10.1213/ane.0000000000007777","url":null,"abstract":"BACKGROUNDIntraoperative neurophysiological monitoring is used to assess neurological function during surgeries placing the spinal cord at risk. Transcranial electrical stimulation muscle motor evoked potentials (Tc-mMEPs) are used to monitor motors tracts, but their interpretation is complicated by the large temporal variability which can result in false-positive warnings. Although the choice of anesthetic drug regimen and drug dose are often claimed to be factors causing this variability, the relationship between depth of anesthesia, quantified by processed electroencephalogram (pEEG) parameters, and Tc-mMEPs characteristics in upper and lower extremity muscles have not yet been rigorously investigated in patients receiving propofol/remifentanil-based anesthesia.METHODSTwenty-five patients were included in this prospective observational study. All received propofol/remifentanil-based total intravenous anesthesia. Depth of anesthesia was quantified by the bispectral index (BIS). After induction of anesthesia, the target propofol concentration was altered to sequentially achieve BIS values of either 30, 40, and 50, or the reverse (direction randomly determined). At each depth of anesthesia Tc-mMEP thresholds were determined, and arterial blood samples were collected. Supramaximal Tc-mMEP signals were recorded every 2 minutes and amplitudes, latencies and area under the curve (AUC) were subsequently calculated. Effects of depth of anesthesia on Tc-mMEP outcomes were analyzed using linear mixed effects modeling.RESULTSThe median (range) age of the study population was 18 (14-66) years (n = 25). In the leg muscles, a decrease of 10 BIS points was associated with a decrease in Tc-mMEP amplitude of 11%-12% (all P < .001; mean [95% confidence interval {CI}], 12% [7.1-16], 11% [6.8-16], and 12% [7.5-16], for the AH, TA, and GAS muscles, respectively). In contrast, no significant amplitude or AUC change was found in the hand muscles (P = .201, 2.8% [-1.5 to 7.1] and P = .076, 4.0% [-0.4 to 7.6], respectively). Latencies changed <0.5% per 10 BIS points decrease (0.03% [-0.3 to 0.2], -0.2% [-0.5 to 0.1], -0.2% [-0.5 to 0.04], 0.3% [0.04-0.6] for the AH, TA, GAS, and hand muscles, respectively), and thresholds increased 3.6% (0.8-7) when BIS decreased from 50 to 30 (P = .037).CONCLUSIONSOur findings challenge some commonly held beliefs. First, our findings suggest that deeper anesthesia has differential effects on the different muscle groups, with little effect on the hand muscles. The current practice of using the hand signals as reference values during procedures below C8/T1 may therefore need re-evaluation. Second, the paucity of effect of depth of anesthesia on Tc-mMEP thresholds and latencies suggests that Tc-mMEP generation is not influenced by deep anesthesia in a clinically relevant way. Therefore, the threshold level monitoring method may provide a more reliable indicator of motor pathway integrity during surgery. This could reduce the likelihood o","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"184 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1213/ane.0000000000007816
Tong J Gan,Zhaosheng Jin,Sabry Ayad,Kumar G Belani,Ashraf S Habib,Tricia A Meyer,Richard D Urman,Benjamin Y Andrew,Sergio D Bergese,Frances Chung,Pierre Diemunsch,Anthony L Kovac,Keith Candiotti,Marina Englesakis,Michael C Grant,Traci L Hedrick,Huang Huang,Peter Kranke,S Julie-Ann Lloyd,Michele A Manahan,Harold S Minkowitz,Beverly K Philip,Brad J Phillips,Katherine D Simpson,Jennifer Stever
{"title":"Fifth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting: Executive Summary.","authors":"Tong J Gan,Zhaosheng Jin,Sabry Ayad,Kumar G Belani,Ashraf S Habib,Tricia A Meyer,Richard D Urman,Benjamin Y Andrew,Sergio D Bergese,Frances Chung,Pierre Diemunsch,Anthony L Kovac,Keith Candiotti,Marina Englesakis,Michael C Grant,Traci L Hedrick,Huang Huang,Peter Kranke,S Julie-Ann Lloyd,Michele A Manahan,Harold S Minkowitz,Beverly K Philip,Brad J Phillips,Katherine D Simpson,Jennifer Stever","doi":"10.1213/ane.0000000000007816","DOIUrl":"https://doi.org/10.1213/ane.0000000000007816","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"170 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1213/ane.0000000000007863
Victor F A Almeida,Manoela Dantas,Diwakar Phuyal,Fanru Shen
{"title":"Enhancing Perioperative Documentation With Artificial Intelligence Scribes in Anesthesiology.","authors":"Victor F A Almeida,Manoela Dantas,Diwakar Phuyal,Fanru Shen","doi":"10.1213/ane.0000000000007863","DOIUrl":"https://doi.org/10.1213/ane.0000000000007863","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1213/ane.0000000000007808
Michele Introna
{"title":"Concerns Regarding \"Single-Syringe Total Intravenous Anesthesia With Propofol and Remifentanil: A Prospective Cohort Study\".","authors":"Michele Introna","doi":"10.1213/ane.0000000000007808","DOIUrl":"https://doi.org/10.1213/ane.0000000000007808","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145559078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1213/ane.0000000000007825
Susan M Goobie,Qinglan Huang,Samir Seshadri,Anna Kordun,Steven J Staffa,Patricia Davenport,Martha Sola-Visner,Joseph Cravero
BACKGROUNDNeonates are the most frequently transfused population perioperatively. Current guidelines based on evidence from neonatal trials and expert consensus recommend restrictive transfusion strategies, with hemoglobin (Hb) transfusion threshold levels between 7.5 and 12.0 g/dL based on gestational age, postnatal age, oxygen dependency, respiratory support, hemodynamic status, and comorbidities. This retrospective observational single center study aimed to assess red blood cell (RBC) transfusion practices in neonates undergoing noncardiac surgery. The rate of RBC transfusion and incidence of over transfusion (Hb ≥12 g/dL) is reported. The relationship between postoperative Hb levels, perioperative RBC transfusion volume, and patient-centered outcomes is explored for transfused neonates.METHODSFollowing approval from the Boston Children's Hospital Institutional Review Board (IRB-P00029159), neonates undergoing noncardiac surgery who received a RBC transfusion in the perioperative period were included. Over transfusion was defined as an immediate postoperative Hb level ≥12.0 g/dL in transfused neonates. Patient demographics, laboratory variables, transfusion exposure, and clinical outcomes pertaining to the perioperative course were analyzed using univariate and multivariable logistic regression models. The primary aim was to define the rate of RBC transfusion in our total neonatal surgical cohort and to define the incidence of perioperative neonatal over transfusion for the transfused neonates. The secondary aims were to identify if patient or surgical factors correlate with the likelihood of perioperative over transfusion and determine if over transfusion and/or a transfusion volume threshold is associated with adverse postoperative outcomes, such as length of hospital or neonatal intensive care unit (NICU) stay, major morbidity, or mortality.RESULTSThe database spanned over a 6-year period from January 2017 to December 2023 and consisted of 1305 neonates who underwent noncardiac surgery at Boston Children's Hospital. In the total neonatal surgical population, the perioperative RBC transfusion rate was 22.8% (297/1305) and the 30-day mortality was 10.9% (30/274). Of those neonates transfused perioperatively, the incidence of over transfusion was 51.1% with 140/274 meeting the criteria for over transfusion (defined as Hb level ≥12.0 g/dL; median Hb 13.9, range: 12.0-21.3). Risk factors for over transfusion were preoperative Hb between 10 and 13 g/dL (odds ratio [OR] = 0.28 [95% confidence interval {CI}, 0.14-0.53]; P < .001) and preoperative Hb <10 g/dL (OR = 0.18 [95% CI, 0.07-0.44]; P < .001). No significant association (negative or positive) was found between over transfusion and postoperative outcomes, such as length of hospital (P = .151) or NICU stay (P = .549), composite morbidity (P = .868), 24-hour mortality (P = .051), 30-day mortality (P = .094), or 1-year mortality (P = .672). Neonates with 30-day postoperative mortality received s
{"title":"Perioperative Blood Transfusion, Postoperative Hemoglobin, and Clinical Outcomes in Neonates: A Retrospective Observational Study From a Large Quaternary Hospital.","authors":"Susan M Goobie,Qinglan Huang,Samir Seshadri,Anna Kordun,Steven J Staffa,Patricia Davenport,Martha Sola-Visner,Joseph Cravero","doi":"10.1213/ane.0000000000007825","DOIUrl":"https://doi.org/10.1213/ane.0000000000007825","url":null,"abstract":"BACKGROUNDNeonates are the most frequently transfused population perioperatively. Current guidelines based on evidence from neonatal trials and expert consensus recommend restrictive transfusion strategies, with hemoglobin (Hb) transfusion threshold levels between 7.5 and 12.0 g/dL based on gestational age, postnatal age, oxygen dependency, respiratory support, hemodynamic status, and comorbidities. This retrospective observational single center study aimed to assess red blood cell (RBC) transfusion practices in neonates undergoing noncardiac surgery. The rate of RBC transfusion and incidence of over transfusion (Hb ≥12 g/dL) is reported. The relationship between postoperative Hb levels, perioperative RBC transfusion volume, and patient-centered outcomes is explored for transfused neonates.METHODSFollowing approval from the Boston Children's Hospital Institutional Review Board (IRB-P00029159), neonates undergoing noncardiac surgery who received a RBC transfusion in the perioperative period were included. Over transfusion was defined as an immediate postoperative Hb level ≥12.0 g/dL in transfused neonates. Patient demographics, laboratory variables, transfusion exposure, and clinical outcomes pertaining to the perioperative course were analyzed using univariate and multivariable logistic regression models. The primary aim was to define the rate of RBC transfusion in our total neonatal surgical cohort and to define the incidence of perioperative neonatal over transfusion for the transfused neonates. The secondary aims were to identify if patient or surgical factors correlate with the likelihood of perioperative over transfusion and determine if over transfusion and/or a transfusion volume threshold is associated with adverse postoperative outcomes, such as length of hospital or neonatal intensive care unit (NICU) stay, major morbidity, or mortality.RESULTSThe database spanned over a 6-year period from January 2017 to December 2023 and consisted of 1305 neonates who underwent noncardiac surgery at Boston Children's Hospital. In the total neonatal surgical population, the perioperative RBC transfusion rate was 22.8% (297/1305) and the 30-day mortality was 10.9% (30/274). Of those neonates transfused perioperatively, the incidence of over transfusion was 51.1% with 140/274 meeting the criteria for over transfusion (defined as Hb level ≥12.0 g/dL; median Hb 13.9, range: 12.0-21.3). Risk factors for over transfusion were preoperative Hb between 10 and 13 g/dL (odds ratio [OR] = 0.28 [95% confidence interval {CI}, 0.14-0.53]; P < .001) and preoperative Hb <10 g/dL (OR = 0.18 [95% CI, 0.07-0.44]; P < .001). No significant association (negative or positive) was found between over transfusion and postoperative outcomes, such as length of hospital (P = .151) or NICU stay (P = .549), composite morbidity (P = .868), 24-hour mortality (P = .051), 30-day mortality (P = .094), or 1-year mortality (P = .672). Neonates with 30-day postoperative mortality received s","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1213/ane.0000000000007810
Francisco A Lobo,Hernan Boveri,Hugo Vereecke,Frank H Engbers
{"title":"To Mix or Not to Mix: Don't Mess With Basic Total Intravenous Anesthesia Pharmacology!","authors":"Francisco A Lobo,Hernan Boveri,Hugo Vereecke,Frank H Engbers","doi":"10.1213/ane.0000000000007810","DOIUrl":"https://doi.org/10.1213/ane.0000000000007810","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1213/ane.0000000000007809
Lauren M Hughes,Claire C Nestor,Michael G Irwin
{"title":"Single-Syringe Total Intravenous Anesthesia: Dosing Concerns.","authors":"Lauren M Hughes,Claire C Nestor,Michael G Irwin","doi":"10.1213/ane.0000000000007809","DOIUrl":"https://doi.org/10.1213/ane.0000000000007809","url":null,"abstract":"","PeriodicalId":7799,"journal":{"name":"Anesthesia & Analgesia","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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