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Evaluation of some trace elements levels in sera of patients with Angina Pectoris in Erbil city 埃尔比勒市心绞痛患者血清中微量元素含量测定
Pub Date : 2014-09-15 DOI: 10.26477/IDJ.V36I3.21
P. Ismail, A. Yousif, N. A. Ismail
Background: Angina pectoris(AP) is one of the most prevalent diseases in developed countries and is becoming an area of increasing concern in other parts of the world. Among the several causes of the disease alteration in the levels of trace elements are also important. Objectives : This study was undertaken in order to investigate the serum trace elements level in patients with Angina pectoris compared to healthy individuals, and to find whether there is any relationship between serum trace elements levels and patients with Angina pectoris.. Methods: The study involved 50 patients with Angina pectoris(AP) for evaluation of these trace elements level ( Se Cu, Zn ,Fe& Cr ) as well as TG, TC and LDL-C and HDL as compared with 50 control subjects . Results The results indicate that patients exhibited significant decrease in the serum of selinum(Se),zinc(Zn), copper(Cu), chromium(Cr) and iron(Fe) level (p<0.001) as compared to the healthy controls. TG, TC and LDL-C were elevated in patients and HDL-C was lower in our patients, Conclusions. Deficiency or suboptimal levels of micronutriants( Se ,Cu, Zn ,Fe& Cr ) may play a role in the development of Angina pectoris(AP). Measurement of serum trace elements level l might provide additional and useful laboratory test for the assessment of the patients with Angina pectoris and oral trace elements may have a role in therapy.
背景:心绞痛(Angina pectoris, AP)是发达国家最常见的疾病之一,在世界其他地区日益受到关注。在引起该病的几个原因中,微量元素水平的改变也很重要。目的:研究心绞痛患者血清微量元素水平与健康人的比较,探讨血清微量元素水平与心绞痛患者之间是否存在关系。方法:对50例心绞痛患者(AP)进行微量元素(Se、Cu、Zn、fe、Cr)、TG、TC、LDL-C、HDL水平的测定,并与50例对照组进行比较。结果患者血清中硒(Se)、锌(Zn)、铜(Cu)、铬(Cr)、铁(Fe)含量较健康对照组显著降低(p<0.001)。患者TG、TC、LDL-C升高,HDL-C降低。微量营养素(硒、铜、锌、铁和铬)的缺乏或亚理想水平可能在心绞痛(AP)的发展中发挥作用。血清微量元素水平的测定可为心绞痛患者的诊断提供补充和有用的实验室检查,口服微量元素可能在治疗中起作用。
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引用次数: 0
Immunohistochemical Evaluation of Epidermal Growth Factor Receptor (EGFR), MMP-2 and Heparanase in Pleomorphic Adenoma of Salivary Glands 涎腺多形性腺瘤中表皮生长因子受体(EGFR)、MMP-2和肝素酶的免疫组化评价
Pub Date : 2014-09-15 DOI: 10.26477/idj.v36i3.23
B. Hamid, S. Sarkis, M. Merza
Background: Salivary gland tumors are morphologically and clinically diverse group of neoplasms .The most common benign tumor is the pleomorphic adenoma, it contains the epithelial, myoepithelial and mesenchymal component, with variable morphological patterns. Epidermal growth factor receptor (EGFR) is a 170 KD glycoprotein which has a tyrosine kinase activity. It is found at abnormally high levels on the surface of many types of cells, so these cells may divide excessively in the presence of epidermal growth factor.MMP-2 is a widely studied matrix metalloproteinase which participates in extracellular matrix (ECM) degradation, having a wide range of substrates and able to degrade type I, IV, V, VII and X collagens, laminin, elastin, fibronectin and proteoglycans. Heparanase (HPA) is an endo-β-D-glucuronidase that has the activity of cleaving heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HSPGs), the major proteoglycans of the extracellular matrix (ECM) and basement membrane (BM) which play a key role in preventing tumor cells invasion and metastasis. Aims of the study: This study aimed to evaluate the expression of EGFR, MMP-2 and heparanase in pleomorphic adenoma of salivary glands and to correlate the expression of the aforementioned biomarkers with the clinical parameters, histological subtypes and components, and with each other as well. Materials and methods: Twenty five paraffin blocks of pleomorphic adenoma were included in this study. Sections immunohistochemically stained with anti EGFR, anti MMP-2 and anti heparanase monoclonal antibodies (Mabs). Results: Positive EGFR, MMP-2 and hepranase immunohistochemical expression was found in 22 (88%), 14(56%) and 21 (84%) of the studied cases respectively. Statistically non- significant correlation was found among the aforementioned markers with each other, and between the markers and any of the clinical parameters and histological classifications, except a statistically highly significant negative correlation revealed regarding EGFR expression with the squamous cells of epithelial component (p =0.001) and a highly significant positive correlation found regarding MMP-2 expression with the chondroid stromal component (0.003). Conclusions: Histological variation of pleomorphic adenoma has no influence on its biological behavior concerning EGFR, MMP-2 and heparanase expression. The immunoscores reorded in this study are expected to contribute to a better understanding of the biological behavior of PA.
背景:唾液腺肿瘤是形态和临床多样的肿瘤群,最常见的良性肿瘤是多形性腺瘤,它包含上皮、肌上皮和间充质成分,形态形态多变。表皮生长因子受体(EGFR)是一种具有酪氨酸激酶活性的170 KD糖蛋白。它在许多类型的细胞表面存在异常高的水平,因此这些细胞在表皮生长因子的存在下可能过度分裂。MMP-2是一种被广泛研究的基质金属蛋白酶,参与细胞外基质(extracellular matrix, ECM)降解,具有广泛的底物,能够降解I、IV、V、VII和X型胶原、层粘连蛋白、弹性蛋白、纤维连接蛋白和蛋白聚糖。肝素酶(HPA)是一种内切β- d -葡萄糖醛酸酶,具有裂解硫酸肝素蛋白聚糖(HSPGs)侧链的活性,而硫酸肝素蛋白聚糖是细胞外基质(ECM)和基底膜(BM)的主要蛋白聚糖,在阻止肿瘤细胞侵袭和转移中起关键作用。研究目的:本研究旨在评估涎腺多形性腺瘤中EGFR、MMP-2和肝素酶的表达,并探讨上述生物标志物的表达与临床参数、组织学亚型和组成的关系,以及它们之间的关系。材料和方法:选取25例多形性腺瘤石蜡切片。切片免疫组织化学染色抗EGFR,抗MMP-2和抗肝素酶单克隆抗体(mab)。结果:EGFR阳性22例(88%),MMP-2阳性14例(56%),肝素酶免疫组化阳性21例(84%)。除EGFR表达与上皮成分鳞状细胞呈极显著负相关(p =0.001), MMP-2表达与软骨样基质成分呈极显著正相关(p = 0.003)外,上述标志物之间、与任何临床参数和组织学分类之间均无统计学意义的相关。结论:多形性腺瘤的组织学变化对其EGFR、MMP-2和肝素酶表达的生物学行为无影响。本研究中记录的免疫评分有望有助于更好地了解PA的生物学行为。
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引用次数: 0
The Effect of Addition of Titanium Oxide Nanofillers on The Water Sorption and Solubility of Resin Based Composite (An In Vitro Study) 纳米二氧化钛填料的加入对树脂基复合材料吸水性和溶解度的影响(体外研究)
Pub Date : 2014-09-15 DOI: 10.26477/IDJ.V36I3.28
S. Saleem, D. Bakr, Dara H. Saeed
Background and Objectives: The aim of this study was to measure the water sorption (Wsp) and water solubility (Wsl) of modified microhybrid composite resins by adding Titanium oxide nanofillers in four concentration 0.5% , 1%, 3% and 5% and comparing them to unmodified microhybrid composite resins and to nanofilled composite resin. Methods: For water sorption (Wsp) and solubility (Wsl), ten disk-shaped specimens of each resin composite were made for each group and stored in desiccators until constant mass was achieved. Specimens were then stored in water for 7 days, and the mass of each specimen was measured. The specimens were dried again and weighed. The Wsp and Wsl were calculated from these measurements. Data analyzed by one-way ANOVA. Results: The results showed there were significant differences among the groups in the Wsp mean values which ranged from 20.2120 to 28.4680 μg/ mm³, while the Wsl mean values were ranged from 1.1060 to 5.6800 μg/ mm³. Conclusion: The addition of TiO2 nanofillers to microhybrid composite increased the Wsp and Wsl values compared to the control group but still lower than the value established by the ISO 4049 standard
背景与目的:本研究通过添加纳米二氧化钛在0.5%、1%、3%和5%的浓度下对改性微杂化复合树脂的吸水性(Wsp)和水溶性(Wsl)进行测定,并与未改性微杂化复合树脂和纳米填充复合树脂进行比较。方法:每组制作10个圆盘状树脂复合材料的吸水性(Wsp)和溶解度(Wsl),保存在干燥器中,直到达到恒定质量。然后将标本在水中保存7 d,并测量每个标本的质量。标本再次干燥并称重。Wsp和Wsl由这些测量值计算。数据采用单因素方差分析。结果:各组间Wsp均值在20.2120 ~ 28.4680 μg/ mm³之间,Wsl均值在1.1060 ~ 5.6800 μg/ mm³之间,差异有统计学意义。结论:微杂复合材料中TiO2纳米填料的加入使Wsp和Wsl值较对照组有所提高,但仍低于ISO 4049标准规定的值
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引用次数: 0
The Effect of Iraqi White Mustard Seed Extracts on Periodontal Disease 伊拉克白芥菜籽提取物对牙周病的影响
Pub Date : 2014-09-15 DOI: 10.26477/IDJ.V36I3.24
A. Ali
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引用次数: 0
Determination of Acrylic Denture Resin Surface Roughness by Different Processing Techniques 不同加工工艺对丙烯酸义齿树脂表面粗糙度的测定
Pub Date : 2014-09-15 DOI: 10.26477/IDJ.V36I3.26
Akhlas Zeid Abood
Background: Poly (methyl methacrylate) (PMMA) seems to be the most commonly used material in the construction of denture base due to its advantages. However, it is still far from being ideal in fulfilling the physical and mechanical properties. Therefore, attempts to improve the properties of PMMA were taken by the researcher through many ways The purpose of this study was to estimate the effect of different processing techniques on surface roughness of acrylic base denture resin. Materials and Methods: A total sample of (50) specimens were prepared; these specimens were divided into 3 main processing techniques, and 5 experimental sub-groups (n=10): Group (A), acrylic denture base material processed by conventional water bath technique (74C for 1 and half hours then boiled for 30 min; Group (B), acrylic resins processed by microwave oven at (500 Watts) for 3 min; Group (C) samples processed by autoclave device with 3 different timing set up : (C1) for l0 min, (C2) for 20 min and (C3) for 30 min. This is done to make a comparison of different autoclave polymerization conditions on the surface roughness of denture base resin. Results: Statistically, there was no significant difference between the traditional water bath group technique and an autoclave system when the specimen processed at (121C/210Kpa) for 30 min. However, there was a statistically significant difference compared to other experimental groups. Conclusion: The autoclave processing technique could be the new alternative system to process the acrylic resin base material alongside the conventional methods. The experimental group prepared by autoclave system at (121C/21Kpa) for 30 min showed an improvement in the surface roughness compared to microwave and water bath techniques.
背景:聚甲基丙烯酸甲酯(PMMA)由于其优点成为义齿基托最常用的材料。然而,它在满足物理和机械性能方面还远远不够理想。因此,研究者尝试通过多种方式来改善PMMA的性能。本研究的目的是评估不同的加工工艺对丙烯酸基托树脂表面粗糙度的影响。材料与方法:共制备标本50份;将标本分为3种主要加工工艺,5个实验亚组(n=10): A组:常规水浴工艺处理丙烯酸基托材料(74C) 1半小时后煮沸30 min;(B)组,丙烯酸树脂经(500瓦)微波炉处理3分钟;(C)组样品经高压灭菌装置处理,设置3种不同的时间:(C1) 10min, (C2) 20min, (C3) 30min。比较不同的高压灭菌聚合条件对义齿基托树脂表面粗糙度的影响。结果:在(121C/210Kpa)条件下处理30min时,传统水浴组技术与高压灭菌系统的差异无统计学意义,但与其他实验组相比差异有统计学意义。结论:高压釜加工技术可作为常规工艺加工丙烯酸树脂基材的一种新的替代系统。在(121C/21Kpa)高压灭菌系统下制备30 min的实验组,与微波和水浴技术相比,表面粗糙度有所改善。
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引用次数: 0
Evaluation of panoramic image quality in three images system. 三图像系统中全景图像质量的评价。
Pub Date : 2014-09-15 DOI: 10.26477/idj.v36i3.22
Amaal kadhim ALSaadi
In vitro study to evaluate the diagnostic image quality of dental panoramic radiography by comparing between conventional and digital systems. Aim of the Study: The aim of this study was to compare and evaluate the image quality of panoramic radiograph. Material and Method: Study comparing the image quality of dental Panoramic between conventional and digital in three dental institutions diagnostic imaging department. Forty five panoramic image were collected and divided in to three groups consisting of conventional images obtained with STRATO 2000, CE by VILLA SISTEMI MEDICALI–ITALY (screen based film) Dimax3digital system pan/ceph, PLANMECA, Helsinki, Finland, and Kodak 8000 carestream health, France (CCD X–ray image sensor). Image quality was assessed by rating the visibility of three evaluation aspect commonly found on panoramic radiographs for each image Depending on three evaluation aspect which is include the anatomy coverage, contrast and density of the teeth and anatomical structure, high score representing better image quality and the lower score indicating poor image quality. Results: the data collected from the evaluation of digital and film based image by two examiner were analyzed by chi square and the difference was statistically significant. Conclusion: The highest quality scores were obtained with carestream health digital system whereas images from Dimax3 digital system and conventional panoramic image type by VILLA SISTEMI were ranked significantly lower.
通过比较传统系统和数字系统,评价口腔全景x线摄影诊断图像质量的体外研究。研究目的:本研究的目的是比较和评价全景x线片的图像质量。材料与方法:比较三所牙科机构诊断影像学常规与数字化牙科全景图像质量的研究。收集45张全景图像并将其分为三组,其中包括由VILLA SISTEMI medici - italy(基于屏幕的胶片)获得的STRATO 2000, CE,芬兰赫尔辛基PLANMECA的dimax3数字系统pan/ceph和法国Kodak 8000 carestream health (CCD x射线图像传感器)获得的常规图像。图像质量是通过对全景x线片上常见的三个评价方面对每张图像的可见性进行评分来评估的,根据三个评价方面包括解剖覆盖、牙齿的对比度和密度以及解剖结构,得分高表示图像质量较好,得分低表示图像质量较差。结果:两名审查员对数字影像和胶片影像的评价数据进行卡方分析,差异有统计学意义。结论:carestream健康数字系统获得的影像质量评分最高,而Dimax3数字系统和VILLA SISTEMI传统全景影像类型的影像质量评分明显较低。
{"title":"Evaluation of panoramic image quality in three images system.","authors":"Amaal kadhim ALSaadi","doi":"10.26477/idj.v36i3.22","DOIUrl":"https://doi.org/10.26477/idj.v36i3.22","url":null,"abstract":"In vitro study to evaluate the diagnostic image quality of dental panoramic radiography by comparing between conventional and digital systems. Aim of the Study: The aim of this study was to compare and evaluate the image quality of panoramic radiograph. Material and Method: Study comparing the image quality of dental Panoramic between conventional and digital in three dental institutions diagnostic imaging department. Forty five panoramic image were collected and divided in to three groups consisting of conventional images obtained with STRATO 2000, CE by VILLA SISTEMI MEDICALI–ITALY (screen based film) Dimax3digital system pan/ceph, PLANMECA, Helsinki, Finland, and Kodak 8000 carestream health, France (CCD X–ray image sensor). Image quality was assessed by rating the visibility of three evaluation aspect commonly found on panoramic radiographs for each image Depending on three evaluation aspect which is include the anatomy coverage, contrast and density of the teeth and anatomical structure, high score representing better image quality and the lower score indicating poor image quality. Results: the data collected from the evaluation of digital and film based image by two examiner were analyzed by chi square and the difference was statistically significant. Conclusion: The highest quality scores were obtained with carestream health digital system whereas images from Dimax3 digital system and conventional panoramic image type by VILLA SISTEMI were ranked significantly lower.","PeriodicalId":78326,"journal":{"name":"Iraqi Dental Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86267187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antiviral Activity of κ-carrageenan Gel on Herpes Simplex Type І, a Human Study: An Open-Label Clinical Trial κ-卡拉胶凝胶对单纯疱疹І型的抗病毒活性研究:一项开放标签临床试验
Pub Date : 2014-06-08 DOI: 10.26477/IDJ.V36I2.17
H. Abdulla, M. Al-Nimer, Aseel J. Ali
Aim of study This study aimed to study the possible application of carrageenan on the illnesses related to the oral cavity by studying its effects in Viral infection presented with herpes simplex in human.(an-open label study) Subjects,materials and methods In this study patients presented with oral herpes simplex lesions were treated with carrageenan gel (0.9%)that was prepared .The gel was applied twice daily and the end-points of the study are the complete healing in absence of any discomfort within a short period of treatment. Results The results showed that two applications of κ-carrageenan per day accelerated the healing process within a short period (1-2 days) without complications or disfigurement in all patients. Conclusion κ –carrageenan besides ι-ond λ- carrageenan is useful in management of viral infection. κ –carrageenan is effective against herpes simplex labialis .
本研究旨在通过研究卡拉胶对人类单纯疱疹病毒感染的影响,探讨其在口腔相关疾病中的可能应用。研究对象、材料和方法本研究中,口腔单纯疱疹病变患者使用制备的角叉菜胶凝胶(0.9%)治疗,凝胶每天两次,研究的终点是在短时间内治疗完全愈合,没有任何不适。结果每天2次应用κ-卡拉胶可在短时间内(1 ~ 2天)加速愈合过程,无并发症和毁容。结论κ -卡拉胶除ι-和λ-卡拉胶外,还可用于治疗病毒感染。κ -卡拉胶对单纯唇疱疹有效。
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引用次数: 0
Evaluation of SBS between Artificial Teeth and Denture Base after Different Surface Treatment 不同表面处理对义齿与义齿基托间SBS的影响
Pub Date : 2014-06-08 DOI: 10.26477/IDJ.V36I2.18
M. A. Abduljabbar, Nihad Hasan Mohammed, Yasameen Ibrahim Mahbas
Background : Fracture or detachment(debond) of artificial plastic teeth from the denture base is a common clinical problem phenomenon.This fracture or detachment could be a result of many variable causes. This study was conducted to compare and evaluate the shear bond strength between artificial denture teeth and denture base material that was cured by conventional method using water path device after application of different surface treatment and to the best of our knowledge no study has been reported using dental cement resin and chemically cure composite as surface treatment. Materials and method: 45 cylindrical sticks of acrylic resin with denture teeth were prepared. Various treatments were done upon the acrylic resin teeth surfaces. The samples were divided into three groups, containing 15 samples for each. Over all the treated surfaces of all groups the first group included, surface treatment with monomer of self-cure acrylic resin that acted as a control group. The second group included the surface treatment with chemically cured composite resin .The third group included the surface treatment with dental cement resin. All surface treatments took time about 180 seconds on the denture teeth surfaces. The shear strengths were measured in a Universal Testing Machine using a knife-edge shear test. Results : The results showed that all surface treatments application improved the shear bond strength (SBS) significantly level at (Pvalue < 0.05) , while the third group (cement resin) showed the highest SBS than other groups.The surface treatments technique in this study influenced the shear bond strength of the tooth to the base . Conclusion : It was concluded that the cement resin surface treatment may be recommended to be applied on the denture teeth lab prior to the denture base processing .This result is of significant importance to improve the solution of fractured or detached artificial teeth from denture base material.
背景:义齿基托断裂或脱粘是临床上常见的问题现象。这种骨折或脱离可能是许多不同原因的结果。本研究比较和评价采用水路装置常规方法固化的义齿基托材料在不同表面处理后与义齿牙体的剪切结合强度,据我们所知,目前还没有使用牙水泥树脂和化学固化复合材料作为表面处理的研究报道。材料与方法:制备了45根圆柱形丙烯酸树脂义齿棒。在丙烯酸树脂牙齿表面进行了各种处理。样本分为三组,每组15个样本。在所有处理过的表面上,包括第一组,用自固化丙烯酸树脂单体进行表面处理,作为对照组。第二组采用化学固化复合树脂进行表面处理,第三组采用牙水泥树脂进行表面处理。假牙表面的所有表面处理大约需要180秒。剪切强度在万能试验机上采用刀口剪切试验进行测定。结果:各表面处理均显著提高了抗剪强度(SBS) (p值< 0.05),其中第3组(水泥树脂)的抗剪强度最高。在本研究中,表面处理技术影响了牙与基牙的剪切结合强度。结论:在义齿基托处理前,推荐在义齿实验室进行水泥树脂表面处理,这对改善义齿基托材料断裂或脱落的解决方案具有重要意义。
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引用次数: 0
Effects of Estradiol, Progesterone and Testosterone on Oral Health Status and Gender Identification of Fetus in Women During Pregnancy 雌二醇、孕酮和睾酮对孕期妇女口腔健康状况和胎儿性别识别的影响
Pub Date : 2014-06-08 DOI: 10.26477/idj.v36i2.15
H. Abdulla, Zeena R Helmi, Zena Kamel Kadhem
Background: The metabolism and immunology of the body are modified by hormones like progesterone, estrogen and testosterone as well as other local factors as dental plaque and calculus. The hormonal changes occurring during pregnancy may be associated with pregnancy gingivitis, gingival bleeding, and pregnancy tumor in the presence of local factors that may accentuate the gingival response. Aims of the study: 1.Find out the association between the oral health status and endogenous sex steroid salivary hormones level. 2.The assessment of fetus gender and compare the clinical and biochemical variables of pregnant with gingivitis who are carrying male fetuses and with those who are carrying female fetuses. Patients and methods: This study was done in Obstetrics and Gynecology Department at Al-Yarmouk Teaching Hospital, from February 2013 to July 2013. Clinical examination had been done for (53) study pregnant women with gingivitis and/or pregnancy tumor at the gestational age range (20-33) and (25) pregnant women with healthy gingiva at gestational age range (22-31), age matched control subjects for check number of gestational age and fetus gender with the consultation of specialist by sonography and confirm the gender in postpartum follow up visits. Oral clinical examination including an assessment of gingival inflammation (GI), plaque amount (PLI), gingival bleeding by (GBI), presence of pregnancy tumor, dental status (DMFT), and salivary flow rate (SFR) had also been done. Samples of whole unstimulated (resting) saliva were collected from all participants then investigated for sex steroids salivary hormonal levels of Estradiol, Progesterone and Testosterone. Results: Gingivitis pregnant and pregnant controls were matched in age. Oral health measurements including: GI, PI and GBI were significantly higher in study compared to controls, while SFR were less in study compared to controls and DMFT showed no significant difference between study and controls. Sex steroids salivary hormonal levels of Estradiol, Progesterone and Testosterone in study pregnant women were higher than that of controls. Prevalence of gingivitis among samples population of present study is 67.9% and the percentage of the presence of pregnancy tumor is 3.8%. PLI significantly correlated with elevated salivary hormones level of Testosterone and Estradiol and non-significantly correlated with salivary hormone level of progesterone.GI significantly correlated with elevated salivary hormones level of Estradiol, Progesterone and Testosterone. GBI significantly correlated with elevated salivary Estradiol hormone level and non-significantly correlated with salivary hormones level of Testosterone and Progesterone. Pregnancy tumor significantly correlated with elevated salivary hormones level of Estradiol, Progesterone and Testosterone. Pregnant women with gingivitis who were carrying females’ fetuses showed significant elevated salivary hormone level of Estradiol and significant elevat
研究背景:孕酮、雌激素、睾酮等激素以及牙菌斑、牙石等局部因素改变了机体的代谢和免疫功能。妊娠期发生的激素变化可能与妊娠期牙龈炎、牙龈出血、妊娠期肿瘤有关,而局部因素的存在可能会加重牙龈的反应。研究目的:了解口腔健康状况与内源性性类固醇唾液激素水平的关系。2.妊娠牙龈炎男胎与女胎的胎儿性别评估及临床生化指标比较。患者和方法:本研究于2013年2月至2013年7月在Al-Yarmouk教学医院妇产科完成。(53)例妊娠期(20 ~ 33岁)患有牙龈炎和/或妊娠肿瘤的孕妇,(25)例妊娠期(22 ~ 31岁)牙龈健康的孕妇,年龄匹配对照,经专科医生咨询,通过超声检查胎龄数和胎儿性别,产后随访确认性别。口腔临床检查包括牙龈炎症(GI)、菌斑数量(PLI)、牙龈出血(GBI)、妊娠肿瘤的存在、牙齿状况(DMFT)和唾液流率(SFR)的评估。研究人员收集了所有参与者的未受刺激(静止)唾液样本,然后调查了性类固醇、唾液中的雌二醇、孕酮和睾酮激素水平。结果:牙龈炎孕妇与妊娠对照组年龄相符。口腔健康指标包括:GI、PI和GBI在研究中显著高于对照组,而SFR在研究中显著低于对照组,DMFT在研究和对照组之间无显著差异。研究孕妇唾液中雌二醇、孕酮和睾酮的水平均高于对照组。本研究样本人群牙龈炎患病率为67.9%,妊娠肿瘤发生率为3.8%。PLI与睾酮、雌二醇唾液激素水平升高显著相关,与孕酮唾液激素水平升高不显著相关。GI与唾液中雌二醇、孕酮、睾酮水平升高有显著相关性。GBI与唾液雌二醇水平升高显著相关,与睾酮、孕酮水平无显著相关。妊娠肿瘤与唾液中雌二醇、孕酮、睾酮水平升高有显著相关性。孕女胎的牙龈炎孕妇与孕男胎的牙龈炎孕妇相比,雌二醇唾液激素水平显著升高,GI、PLI、GBI显著升高,孕酮、睾酮唾液激素水平及SFR、DMFT差异无统计学意义。
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引用次数: 1
Early Effect of Simvastatin Gel on Bone Formation of Orthopaedically Expanded Sagittal Suture of Rabbits 辛伐他汀凝胶对兔矫形扩张矢状缝骨形成的早期影响
Pub Date : 2014-06-08 DOI: 10.26477/IDJ.V36I2.14
A. Mahmood, Khudhair Adday Salman Al-Jumaili, H. I. Al-Sadi
OBJECTIVES: To evaluate early bone-healing effects of local simvastatin application to orthopaedically expanded sagittal suture of rabbits. MATERIALS AND METHODS: A total of 30 male Rabbits of an average weight of 0 .75-1.0 kg and aged 2-3 months were used in this study. The animals were divided into three groups of ten animals each: simvastatin (group I), active control (group II), and passive control (group III). The sagittal suture was expanded with an expansion spring for one week, after that, the expander was removed and replaced with wire retainer for two weeks .At the time of wire retainer placement: Group I received an injection of 0.5mg simvastatin /0.5ml methylcellulose gel over the suture; group II received 0.5 ml of methylcellulose gel subcutaneously over the expanded suture; group III received no treatment. Half of the animals (five animals in each group) were sacrificed after two weeks of retention, and the sutures were prepared for radiological and histological assessment of regenerated bone. In the other half, the wire retainer was removed after two weeks of retention and the relapsed ratio of the expanded suture was calculated one week later. RESULTS: Local application of simvastatin has been found to have a positive influence on bone regeneration of orthopaedically expanded sagittal suture in comparison to control group. The density of the suture in the simvastatin group was significantly higher than control group. The relapse ratio in simvastatin gel treated group was nearly half that of methyl cellulose carrier gel and control groups, the difference was highly significant. CONCLUSION: 0.5 mg simvastatin greatly promote early bone formation of orthopaedically expanded sagittal suture.
目的:评价辛伐他汀局部应用于兔矫形扩大矢状缝的早期骨愈合效果。材料与方法:选用平均体重0.75 ~ 1.0 kg、2 ~ 3月龄雄性家兔30只。将动物分为三组,每组10只:辛伐他汀组(ⅰ组)、主动对照组(ⅱ组)和被动对照组(ⅲ组)。矢状缝线用膨胀弹簧扩张1周,之后取出扩张器,用金属丝固定器置换2周。放置金属丝固定器时:ⅰ组在缝线上注射0.5mg辛伐他汀/0.5ml甲基纤维素凝胶;II组在扩大缝合处皮下注射0.5 ml甲基纤维素凝胶;第三组不接受任何治疗。留置2周后处死一半动物(每组5只),准备缝线进行再生骨的放射学和组织学评估。另一半患者留置2周后取出固定器,1周后计算扩大缝合的复发率。结果:与对照组相比,局部应用辛伐他汀对骨科扩张矢状缝骨再生有积极影响。辛伐他汀组缝合密度显著高于对照组。辛伐他汀凝胶治疗组复发率接近甲基纤维素载体凝胶和对照组的一半,差异极显著。结论:0.5 mg辛伐他汀对矫形扩张矢状缝早期骨形成有明显促进作用。
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Iraqi Dental Journal
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