Pub Date : 1970-01-01DOI: 10.1177/030098587000700608
I T Budiarso, W W Carlton, J F Tuite
A hepatogenous phototoxic syndrome was induced in mice by the feeding of rice cultures of P. viridicaunn and exposure to sunlight. The pathologic changes in the livers and skin were similar to those described in facial eczema of sheep in New Zealand and Bermuda-grass and alfalfa-hay toxicoses in the United States of America. The phototoxic syndrome was characterized by congestion of the pinna followed by erythema and edema of the cars, muzzle, paws, and tail, occasionally accompanied by alopecia. In some mice the tip of the ears became gangrenous and sloughed. Keratitis and keratoeonus leading to blindness occurred. The incidence of phototoxic reactions was higher in older mice and in those subjected to delayed exposure to sunlight. Aspermatogenesis and formation of syncytial spermatids occurred in some mice.
{"title":"Phototoxic syndrome induced in mice by rice cultures of Penicillium viridicatum and exposure to sunlight.","authors":"I T Budiarso, W W Carlton, J F Tuite","doi":"10.1177/030098587000700608","DOIUrl":"https://doi.org/10.1177/030098587000700608","url":null,"abstract":"A hepatogenous phototoxic syndrome was induced in mice by the feeding of rice cultures of P. viridicaunn and exposure to sunlight. The pathologic changes in the livers and skin were similar to those described in facial eczema of sheep in New Zealand and Bermuda-grass and alfalfa-hay toxicoses in the United States of America. The phototoxic syndrome was characterized by congestion of the pinna followed by erythema and edema of the cars, muzzle, paws, and tail, occasionally accompanied by alopecia. In some mice the tip of the ears became gangrenous and sloughed. Keratitis and keratoeonus leading to blindness occurred. The incidence of phototoxic reactions was higher in older mice and in those subjected to delayed exposure to sunlight. Aspermatogenesis and formation of syncytial spermatids occurred in some mice.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 6","pages":"531-46"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700608","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16604039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700302
N F Cheville, R C Cutlip, H W Moon
Microscopie changes in tissues of 8 dogs with the gray collie syndrome (GCS) and in 5 related non-gray dogs were described. Three of the GCS dogs died as neonates, 2 as puppies, and 3 (treated clinically) as adults. Clinical signs of disease were abnormal hair pigmentation, cyclic neutropenia, diarrhea, lameness, and chronic ulceration of oral and genital mucosa. Lesions included lymphoid atrophy, amyloidosis, enteritis, aseptic bone necrosis, and acute and chronic purulent inflammation of several organs. Abnormalities in serum included decreased albumin and increased γ- and α-globulin. Electron microscopy of the spleen revealed amyloid fibers deposited chiefly at the periphery of the splenic follicles and within the central artery. Tissues from non-gray related dogs were normal except for laminar malacia of the motor areas of the cerebral cortex in 3 of these dogs which probably resulted from ischemia due to epileptiform seizures.
{"title":"Microscopic pathology of the gray collie syndrome. Cyclic neutropenia, amyloidosis, enteritis, and bone necrosis.","authors":"N F Cheville, R C Cutlip, H W Moon","doi":"10.1177/030098587000700302","DOIUrl":"https://doi.org/10.1177/030098587000700302","url":null,"abstract":"Microscopie changes in tissues of 8 dogs with the gray collie syndrome (GCS) and in 5 related non-gray dogs were described. Three of the GCS dogs died as neonates, 2 as puppies, and 3 (treated clinically) as adults. Clinical signs of disease were abnormal hair pigmentation, cyclic neutropenia, diarrhea, lameness, and chronic ulceration of oral and genital mucosa. Lesions included lymphoid atrophy, amyloidosis, enteritis, aseptic bone necrosis, and acute and chronic purulent inflammation of several organs. Abnormalities in serum included decreased albumin and increased γ- and α-globulin. Electron microscopy of the spleen revealed amyloid fibers deposited chiefly at the periphery of the splenic follicles and within the central artery. Tissues from non-gray related dogs were normal except for laminar malacia of the motor areas of the cerebral cortex in 3 of these dogs which probably resulted from ischemia due to epileptiform seizures.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 3","pages":"225-45"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16613242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700203
L F James, K R Van Kampen, W J Hartley
The toxic effect on pregnant two of Swainsona galegifolia (collected in Australia) and of Astragalus pubentissimus and A. Ientiginosus (collected in the United States) were compared. The signs of intoxication, vacuolar lesions, and clinicopathologic changes were similar. These similarities suggest that the toxic agent or agents may be the same in both genera. Some sheep fed Astragalus aborted and some delivered deformed lambs while those fed Swainsona did not.
{"title":"Comparative pathology of Astragalus (locoweed) and Swainsona poisoning in sheep.","authors":"L F James, K R Van Kampen, W J Hartley","doi":"10.1177/030098587000700203","DOIUrl":"https://doi.org/10.1177/030098587000700203","url":null,"abstract":"The toxic effect on pregnant two of Swainsona galegifolia (collected in Australia) and of Astragalus pubentissimus and A. Ientiginosus (collected in the United States) were compared. The signs of intoxication, vacuolar lesions, and clinicopathologic changes were similar. These similarities suggest that the toxic agent or agents may be the same in both genera. Some sheep fed Astragalus aborted and some delivered deformed lambs while those fed Swainsona did not.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 2","pages":"116-25"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16614679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700207
G M Zwicker
A middle-aged female mongrel dog became progressively thinner and developed a large, moderately firm, pale yellow, multinodular tumor, without obvious encapsulation behind the right shoulder between the cutaneous trunci and Intissimus dorsi muscles. Histologically the tumor teas a liposarcoma.
{"title":"Liposarcoma in a dog.","authors":"G M Zwicker","doi":"10.1177/030098587000700207","DOIUrl":"https://doi.org/10.1177/030098587000700207","url":null,"abstract":"A middle-aged female mongrel dog became progressively thinner and developed a large, moderately firm, pale yellow, multinodular tumor, without obvious encapsulation behind the right shoulder between the cutaneous trunci and Intissimus dorsi muscles. Histologically the tumor teas a liposarcoma.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 2","pages":"145-7"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16614683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700105
K Altera, L Clark
A description of equine cutaneous mastocytosis is given. The lesion was characterized by focal aggregates of mast cells, and by eosinophils, fibrinoid necrosis of collagen, and focal necrosis with dystrophic mineralization of necrotic debris. This is an uncommon, previously undescribed lesion in horses. The authors encountered 14 cases in a 16-year period. The etiology and nature of the lesion are undetermined. Morphologic similarities to canine cutaneous mast-cell tumors, cutaneous lesions of collagen diseases, and calcinosis circumscripta are noted and the possibility of relationships to these lesions is discussed.
{"title":"Equine cutaneous mastocytosis.","authors":"K Altera, L Clark","doi":"10.1177/030098587000700105","DOIUrl":"https://doi.org/10.1177/030098587000700105","url":null,"abstract":"A description of equine cutaneous mastocytosis is given. The lesion was characterized by focal aggregates of mast cells, and by eosinophils, fibrinoid necrosis of collagen, and focal necrosis with dystrophic mineralization of necrotic debris. This is an uncommon, previously undescribed lesion in horses. The authors encountered 14 cases in a 16-year period. The etiology and nature of the lesion are undetermined. Morphologic similarities to canine cutaneous mast-cell tumors, cutaneous lesions of collagen diseases, and calcinosis circumscripta are noted and the possibility of relationships to these lesions is discussed.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 1","pages":"43-55"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15210132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700102
M F el-Etreby
Thirty-four of 42 hearts from apparently normal camels were infested with sarcosporidia. Cysts were invariably found in the papillary muscle of the left ventricular wall; in 12 hearts they were in the right ventricular wall and in 1 heart in Purkinje fibers. None was found in the auricular muscles. An acute non-suppurative focal interstitial myocarditis occurred in association with the sarcocysts in 10 of the affected hearts. This reaction may be caused by a toxin from the cysts or it may be an allergic type of response in a previously sensitized host.
{"title":"Myocaddial sarcosporidiosis in the camel.","authors":"M F el-Etreby","doi":"10.1177/030098587000700102","DOIUrl":"https://doi.org/10.1177/030098587000700102","url":null,"abstract":"Thirty-four of 42 hearts from apparently normal camels were infested with sarcosporidia. Cysts were invariably found in the papillary muscle of the left ventricular wall; in 12 hearts they were in the right ventricular wall and in 1 heart in Purkinje fibers. None was found in the auricular muscles. An acute non-suppurative focal interstitial myocarditis occurred in association with the sarcocysts in 10 of the affected hearts. This reaction may be caused by a toxin from the cysts or it may be an allergic type of response in a previously sensitized host.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16084088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700405
G Migaki, K A Langheinrich
Mastocytomas of the skin of the lower jaw were found in an 8-month-old slaughtered pig. The neoplasms had granules characteristic of mast cells, were localized in the cutaneous tissue, and had not metastasized.
{"title":"Mastocytoma in a pig.","authors":"G Migaki, K A Langheinrich","doi":"10.1177/030098587000700405","DOIUrl":"https://doi.org/10.1177/030098587000700405","url":null,"abstract":"Mastocytomas of the skin of the lower jaw were found in an 8-month-old slaughtered pig. The neoplasms had granules characteristic of mast cells, were localized in the cutaneous tissue, and had not metastasized.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 4","pages":"353-5"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16090977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700209
K H Johnson, C A Osborne, D M Barnes
Pancreatic amyloidosis and basophilic myelogenous sarcoma were diagnosed in a 16-year-old, spayed female domestic shorthaired cat. This report focuses attention on unusual cytoplasmic changes in pancreatic acinar cells, possibly related to extracellular amyloid, The intracellular substance in acinar cells reacted similarly to extracellular amyloid when stained with crystal violet, thioflavine T, and PAS but did not stain or elicit green birefringence with Congo red. The intracytoplasmic material in acinar cells may represent a non-fibrillar amyloid precursor. Amyloid was demonstrable only in the pancreas.
{"title":"Intracellular substance with some amyloid staining affinities in pancreatic acinar cells of a cat with amyloidosis.","authors":"K H Johnson, C A Osborne, D M Barnes","doi":"10.1177/030098587000700209","DOIUrl":"https://doi.org/10.1177/030098587000700209","url":null,"abstract":"Pancreatic amyloidosis and basophilic myelogenous sarcoma were diagnosed in a 16-year-old, spayed female domestic shorthaired cat. This report focuses attention on unusual cytoplasmic changes in pancreatic acinar cells, possibly related to extracellular amyloid, The intracellular substance in acinar cells reacted similarly to extracellular amyloid when stained with crystal violet, thioflavine T, and PAS but did not stain or elicit green birefringence with Congo red. The intracytoplasmic material in acinar cells may represent a non-fibrillar amyloid precursor. Amyloid was demonstrable only in the pancreas.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 2","pages":"153-62"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15217454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700501
K M Charlton, K R Pierce
The sequential development of the lesions in the peripheral nervous systems of 22 goats poisoned with daily oral doses of ground coyotillo fruits was studied. Studies of teased fibers revealed swelling of Schwann cells, clefts in the myelin sheath, segmental demyelination, remyelination, Wallerian degeneration, and regeneration. A few fibers had a large globular or ovoid swelling in a transitional zone between a region undergoing segmental demyelination at one end and Wallerian degeneration at the other end. These distended transitional zones were the sites of intense acid phosphatase activity in axons.These histologic studies indicate that the primary lesion occurred in Schwann cells and resulted in swelling of Schwann cells, clefts in the myelin sheath, and segmental demyclination. The sequence of development of the lesions suggests that axonal degeneration were secondary to Schwann-cell injury.
{"title":"A neuropathy in goats caused by experimental coyotiool (Karwinskia humboldtiana) poisoning. II. Lesions in the peripheral nervous system--teased fiber and acid phosphatase studies.","authors":"K M Charlton, K R Pierce","doi":"10.1177/030098587000700501","DOIUrl":"https://doi.org/10.1177/030098587000700501","url":null,"abstract":"The sequential development of the lesions in the peripheral nervous systems of 22 goats poisoned with daily oral doses of ground coyotillo fruits was studied. Studies of teased fibers revealed swelling of Schwann cells, clefts in the myelin sheath, segmental demyelination, remyelination, Wallerian degeneration, and regeneration. A few fibers had a large globular or ovoid swelling in a transitional zone between a region undergoing segmental demyelination at one end and Wallerian degeneration at the other end. These distended transitional zones were the sites of intense acid phosphatase activity in axons.These histologic studies indicate that the primary lesion occurred in Schwann cells and resulted in swelling of Schwann cells, clefts in the myelin sheath, and segmental demyclination. The sequence of development of the lesions suggests that axonal degeneration were secondary to Schwann-cell injury.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 5","pages":"385-407"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15433424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1970-01-01DOI: 10.1177/030098587000700503
K M Charlton, K R Pierce
Lesions in peripheral nerves from 12 goats poisoned experimentally with coyotillo were studied by light and electron microscopy. The goats were poisoned with daily oral doses of the ground coyotillo fruits and killed at various times after the first day of dosing. Lesions at a mid-femoral site of the sciatic nerve included swelling of Schwann cells, degeneration of mitochondria, depletion of glycogen, splitting of myelin, segmental demyelination, and Wallerian degeneration. The results were suggestive of primary mitochondrial injury in Schwann cells with resultant impaired active transport, intracellular edema, splitting of myelin, and segmental demyelination.
{"title":"A neuropathy in goats caused by experimental coyotiool (Karwinskia humboldtiana) poisoning. IV. Light and electron microscopic lesions in peripheral nerves.","authors":"K M Charlton, K R Pierce","doi":"10.1177/030098587000700503","DOIUrl":"https://doi.org/10.1177/030098587000700503","url":null,"abstract":"Lesions in peripheral nerves from 12 goats poisoned experimentally with coyotillo were studied by light and electron microscopy. The goats were poisoned with daily oral doses of the ground coyotillo fruits and killed at various times after the first day of dosing. Lesions at a mid-femoral site of the sciatic nerve included swelling of Schwann cells, degeneration of mitochondria, depletion of glycogen, splitting of myelin, segmental demyelination, and Wallerian degeneration. The results were suggestive of primary mitochondrial injury in Schwann cells with resultant impaired active transport, intracellular edema, splitting of myelin, and segmental demyelination.","PeriodicalId":78533,"journal":{"name":"Pathologia veterinaria","volume":"7 5","pages":"420-34"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/030098587000700503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15436929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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