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Assessing methods to ascertain persistence and adherence of oral anticoagulants in patients with atrial fibrillation 评估确定心房颤动患者口服抗凝药持续性和依从性的方法。
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-18 DOI: 10.1016/j.ahj.2024.09.004
Anran Tan MS , Sushama Kattinakere Sreedhara MBBS, MSPH , Massimiliano Russo PhD , Daniel E Singer MD , Julie C. Lauffenburger PharmD, PhD , Elyse DiCesare BA , Kueiyu Joshua Lin MD, ScD

Background

Persistence and adherence to oral anticoagulants (OACs) is crucial for its effectiveness in stroke prevention in atrial fibrillation (AF). We aimed to assess the impact of different ascertainment methods on estimated persistence rates.

Methods

We conducted a retrospective cohort study based on the Medicare claims data (01/01/2013-12/31/2019). We built an incident user cohort of OAC (apixaban, dabigatran, edoxaban, rivaroxaban, and warfarin) prescription filling. We measured OAC medication persistence and adherence using the following approaches: (1) treatment-anniversary based persistence: if there is an active prescription overlapping the 180th and 365th day with vs. without a 15-day buffer period (i.e., overlapping with 165th-195th and 350th-380th day); (2) dispensing-gap-based persistence: if there is OAC discontinuation defined as having gap between prescriptions more than a threshold (e.g., 5-60 days) and secondarily, (3) proportion of days covered (PDC) adherence: proportion of days in which patient had filled medication available over the 365-day interval.

Results

We identified 1,398,692 patients who initiated OACs during the study interval. With the treatment-anniversary based approach, only 51.2% to 65.4% of the patients persisted with the medication for either warfarin or DOACs at 180 days, and the number dropped to 43.4% to 60.7% at 1 year. Adding a 15-day buffer period increased the treatment-anniversary based persistence rates by 6.5% to 10.5%. When the allowable gap increased from 5 to 60 days, the persistence rates increased by 36.3% to 42.4% for all OACs. Apixaban users had the highest PDC (74%-75%) over the 365 days, compared to other OACs (60%-69%).

Conclusions

We found that the estimated persistence rates are sensitive to the choice of ascertainment methods. When reporting and comparing persistence findings using the claims database, definitions of OAC discontinuation must be clearly delineated.
背景:口服抗凝药(OACs)的持续性和依从性是其有效预防心房颤动(AF)患者中风的关键。我们旨在评估不同确认方法对估计持续率的影响:我们基于医疗保险理赔数据(01/01/2013-12/31/2019)开展了一项回顾性队列研究。我们建立了一个 OAC(阿哌沙班、达比加群、依度沙班、利伐沙班和华法林)处方填充的事件用户队列。我们采用以下方法测量 OAC 的用药持续性和依从性:1) 基于治疗周年纪念日的持续性:如果有效处方与第 180 天和第 365 天重叠,且有 15 天缓冲期(即与第 165-195 天和第 350-380 天重叠);2) 基于配药间隙的持续性:如果有 OAC 停药,即处方间隙超过阈值(如 5 至 60 天),其次是有 OAC 停药、5至60天),其次是3)覆盖天数比例(PDC)的依从性:在365天的间隔期内,患者已服药的天数比例:结果:我们发现有 1,398,692 名患者在研究期间开始使用 OAC。采用基于治疗纪念日的方法后,只有 51.2% 至 65.4% 的患者在 180 天内坚持服用华法林或 DOACs,一年后这一比例降至 43.4% 至 60.7%。增加 15 天缓冲期后,基于治疗周年的坚持率增加了 6.5% 至 10.5%。当允许的间隙从 5 天增加到 60 天时,所有 OAC 的持续率都增加了 36.3% 到 42.4%。与其他 OACs(60% 至 69%)相比,阿哌沙班使用者在 365 天内的 PDC(74% 至 75%)最高:我们发现,估计的持续率对确定方法的选择很敏感。在使用索赔数据库报告和比较持续率结果时,必须明确界定停用 OAC 的定义。
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引用次数: 0
Enrollment strategies in the era of digital revolution: Experience from a remote health management program 数字革命时代的注册策略:远程健康管理计划的经验。
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-18 DOI: 10.1016/j.ahj.2024.09.005
Shahzad Hassan MD, MS , Lee-Shing Chang MD , Daniel Gabovitch MBA , Jacqueline Chasse NP , Gretchen Stern PhD , Caitlin Colling MD , David Zelle BA , Christopher P. Cannon MD , Deborah Wexler MD , Benjamin M. Scirica MD, MPH , Alexander J. Blood MD, MSc
We describe the strategies used to identify and enroll participants in a remote health management program aimed at optimizing diabetes care in patients at high cardiovascular and kidney risk. Using a combination of digital and traditional outreach methods, including patient portals, emails, mailed letters, and provider referrals, we successfully enrolled 200 participants. Our experience highlights the effectiveness of a hybrid approach in achieving enrollment targets, addressing the challenges of identification of eligible candidates and engagement while integrating traditional methods for inclusivity.
我们分享了在随机远程实施试验中识别和招募参与者的策略经验。我们的目标是评估各种数字和传统筛查及外联方法在参与者注册方面的有效性。本研究的重点是了解与患者参与不同方法相关的成功经验和挑战。
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引用次数: 0
Rationale and design of CHD PULSE: Congenital Heart Disease Project to Understand Lifelong Survivor Experience 先天性心脏病 PULSE:了解幸存者终生经历的先天性心脏病项目的原理和设计。
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-17 DOI: 10.1016/j.ahj.2024.09.003
Matthew E. Oster MD MPH , Yanxu Yang DrPH , Caroline Shi MPH , Susan Anderson BA , Jessica Knight PhD , Logan G. Spector PhD , Osamah Aldoss MD , Charles E. Canter MD , Mansi Gaitonde MD , Gurumurthy Hiremath MD , Anitha John MD , Deborah J. Kozik DO , Bradley S. Marino MD , Kimberly E. McHugh MD , David Overman MD , Geetha Raghuveer MD , James Louis St. MD , Jeffrey P. Jacobs MD , Michelle Gurvitz MD, MPH , Grace Smith BS , Lazaros K. Kochilas MD, MSCR

Background

With improved survival of adults with congenital heart disease (CHD) comes a need to understand the lifelong outcomes of this population. The aim of this paper is to describe the rationale and design of Congenital Heart Disease Project to Understand Lifelong Survivor Experience (CHD PULSE), a study to determine long-term medical, neurocognitive, and psychosocial outcomes among adults with a history of intervention for CHD and to identify factors associated with those outcomes.

Methods

CHD PULSE is a cross-sectional survey conducted from September 2021 to April 2023 among adults aged 18 and older with a history of at least 1 intervention for CHD at 1 of 11 participating U.S. centers in the Pediatric Cardiac Care Consortium. Participants with CHD were asked to complete a 99-question survey on a variety of topics including: demographics, surgeries, health insurance, health care, heart doctors, general health, height and weight, education and work history, reproductive health (for women only), and COVID-19. To construct a control group for the study, siblings of survey respondents were invited to complete a similar survey. Descriptive statistics for demographics, disease severity, center, and method of survey completion were computed for participants and controls. Comparisons were made between participants and non-participants to assess for response bias and between CHD participants and sibling controls to assess for baseline differences.

Results

Among the 14,322 eligible participants, there were 3,133 respondents (21.9%) from 48 U.S. states with surveys returned for inclusion in the study. Sibling contact information was provided by 691 respondents, with surveys returned by 326 siblings (47.2%). The median age of participants was 32.8 years at time of survey completion, with an interquartile range of 27.2 years to 39.7 years and an overall range of 20.1 to 82.9 years. Participants were predominantly female (55.1%) and of non-Hispanic White race/ethnicity (87.1%). There were no differences between participants and non-participants regarding severity of CHD. Compared to nonparticipants, participants were more likely to be female, of older age, and be of non-Hispanic White race/ethnicity. Enrolled siblings were more likely to be female and slightly younger than participants.

Conclusions

With surveys from 3,133 participants from across the U.S., CHD PULSE is poised to provide keen insights into the lifelong journey of those living with CHD, extending beyond mere survival. These insights will offer opportunities for informing strategies to enhance and improve future outcomes for this population of patients.
背景:随着先天性心脏病(CHD)成人存活率的提高,人们需要了解这一人群的终生结局。本文旨在介绍 "了解先天性心脏病患者终生生存体验项目"(CHD PULSE)的原理和设计,该项目旨在确定有先天性心脏病干预史的成年人的长期医疗、神经认知和社会心理结果,并确定与这些结果相关的因素:CHD PULSE 是一项横断面调查,调查时间为 2021 年 9 月至 2023 年 4 月,调查对象为 18 岁及以上曾在美国儿科心脏病护理联盟的 11 个参与中心之一接受过至少一次心脏病干预的成年人。患有先天性心脏病的参与者需要完成一份包含 99 个问题的调查,内容涉及人口统计学、手术、医疗保险、医疗保健、心脏病医生、一般健康状况、身高和体重、教育和工作经历、生殖健康(仅限女性)以及 COVID-19。为建立研究对照组,调查对象的兄弟姐妹也受邀完成了类似的调查。对参与者和对照组的人口统计学、疾病严重程度、中心和调查完成方式进行了描述性统计。对参与者和非参与者进行了比较,以评估回复偏差,并对 CHD 参与者和兄弟姐妹对照组进行了比较,以评估基线差异:在符合条件的 14,322 名参与者中,有来自美国 48 个州的 3133 名受访者(21.9%)寄回了调查问卷,并被纳入研究范围。691名受访者提供了兄弟姐妹的联系信息,326名兄弟姐妹(47.2%)交回了调查问卷。完成调查时,参与者的年龄中位数为 32.8 岁,四分位数之间的范围为 27.2 岁至 39.7 岁,总范围为 20.1 岁至 82.9 岁。参与者主要为女性(55.1%)和非西班牙裔白人(87.1%)。参与者和非参与者在心脏病严重程度方面没有差异。与非参与者相比,参与者更可能是女性、高龄者和非西班牙裔白人。与参与者相比,参与者的兄弟姐妹更可能是女性,且年龄略小:通过对全美 3133 名参与者的调查,CHD PULSE 将为心脏病患者的终生历程提供敏锐的洞察力,而不仅仅是生存。这些洞察力将为制定相关策略提供机会,以提高和改善这类患者的未来治疗效果。
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引用次数: 0
Trends in cancer and heart failure related mortality in adult US population: A CDC WONDER database analysis from 1999 to 2020 美国成年人中与癌症和心力衰竭相关的死亡率趋势:疾病预防控制中心 WONDER 数据库对 1999 年至 2020 年的分析。
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-17 DOI: 10.1016/j.ahj.2024.09.002
Shurjeel Uddin Qazi MBBS , Arsalan Hamid MD , Huzaifa Ul Haq Ansari MBBS , Michel G. Khouri MD , Markus S. Anker , Michael E. Hall MD , Stefan D. Anker , Javed Butler MD, MPH, MBA , Muhammad Shahzeb Khan MD, MS

Background

With the advent of novel chemotherapy, survival of patients with cancer has improved. However, people with cancer have an increased risk of heart failure (HF). Conversely, HF-related mortality may undermine survival among people with cancer. We aim to analyze the trends of mortality in people with HF and cancer in the adult US population.

Methods

We conducted an examination of death certificates sourced from the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database, from the years 1999 to 2020. Mortality in adults with HF and cancer was assessed. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change were reported.

Results

Between 1999 and 2020, 621,783 deaths occurred from HF in people with cancer. The AAMR declined from 16.4 in 1999 to 11.9 in 2017, after which an increase to 14.5 was observed in 2020. Men had consistently higher overall AAMR as compared to women (men = 18.1 vs women = 9.9). Similar AAMR was observed between non-Hispanic (NH) Blacks/African Americans (13.9) and NH Whites (13.3), with lower in American Indian/Alaska Native (9.6) and Hispanics (7.4). Asian/Pacific Islanders reported the lowest AAMR (5.7). The Midwestern region reported the highest AAMR (14.8). We observed the highest AAMR amongst the older population (61.4).

Conclusion

The mortality rates of people with HF and cancer are increasing in the adult U.S. population. This underscores the need for increased screening, aggressive management, and subsequent surveillance of people at risk or with manifested HF in people with cancer.
背景:随着新型化疗的出现,癌症患者的生存率有所提高。然而,癌症患者患心力衰竭(HF)的风险也在增加。相反,与心力衰竭相关的死亡率可能会影响癌症患者的生存。我们旨在分析美国成年人口中心力衰竭和癌症患者的死亡率趋势:我们对来自美国疾病控制与预防中心 WONDER(美国疾病控制与预防中心流行病学研究广泛在线数据)数据库的 1999 年至 2020 年死亡证明书进行了研究。对患有高血压和癌症的成人死亡率进行了评估。报告了每 10 万人的年龄调整死亡率(AAMRs)和每年的百分比变化:结果:1999 年至 2020 年间,621,783 例癌症患者死于高血压。AAMR从1999年的16.4下降到2017年的11.9,之后在2020年又上升到14.5。与女性相比,男性的总体急性心肌梗死死亡率一直较高(男性 = 18.1 vs 女性 = 9.9)。非西班牙裔(NH)黑人/非洲裔美国人(13.9)和 NH 白人(13.3)之间的 AAMR 相似,而美国印第安人/阿拉斯加原住民(9.6)和西班牙裔美国人(7.4)较低。亚裔/太平洋岛民的 AAMR 最低(5.7)。中西部地区报告的 AAMR 最高(14.8)。我们观察到老年人口的 AAMR 最高(61.4):结论:在美国成年人口中,高血压和癌症患者的死亡率正在上升:结论:在美国成年人群中,心房颤动合并癌症患者的死亡率正在上升:这强调了对癌症患者中的高危人群或有心房颤动表现的人群加强筛查、积极管理和后续监测的必要性。
{"title":"Trends in cancer and heart failure related mortality in adult US population: A CDC WONDER database analysis from 1999 to 2020","authors":"Shurjeel Uddin Qazi MBBS ,&nbsp;Arsalan Hamid MD ,&nbsp;Huzaifa Ul Haq Ansari MBBS ,&nbsp;Michel G. Khouri MD ,&nbsp;Markus S. Anker ,&nbsp;Michael E. Hall MD ,&nbsp;Stefan D. Anker ,&nbsp;Javed Butler MD, MPH, MBA ,&nbsp;Muhammad Shahzeb Khan MD, MS","doi":"10.1016/j.ahj.2024.09.002","DOIUrl":"10.1016/j.ahj.2024.09.002","url":null,"abstract":"<div><h3>Background</h3><div>With the advent of novel chemotherapy, survival of patients with cancer has improved. However, people with cancer have an increased risk of heart failure (HF). Conversely, HF-related mortality may undermine survival among people with cancer. We aim to analyze the trends of mortality in people with HF and cancer in the adult US population.</div></div><div><h3>Methods</h3><div>We conducted an examination of death certificates sourced from the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database, from the years 1999 to 2020. Mortality in adults with HF and cancer was assessed. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change were reported.</div></div><div><h3>Results</h3><div>Between 1999 and 2020, 621,783 deaths occurred from HF in people with cancer. The AAMR declined from 16.4 in 1999 to 11.9 in 2017, after which an increase to 14.5 was observed in 2020. Men had consistently higher overall AAMR as compared to women (men = 18.1 vs women = 9.9). Similar AAMR was observed between non-Hispanic (NH) Blacks/African Americans (13.9) and NH Whites (13.3), with lower in American Indian/Alaska Native (9.6) and Hispanics (7.4). Asian/Pacific Islanders reported the lowest AAMR (5.7). The Midwestern region reported the highest AAMR (14.8). We observed the highest AAMR amongst the older population (61.4).</div></div><div><h3>Conclusion</h3><div>The mortality rates of people with HF and cancer are increasing in the adult U.S. population. This underscores the need for increased screening, aggressive management, and subsequent surveillance of people at risk or with manifested HF in people with cancer.</div></div>","PeriodicalId":7868,"journal":{"name":"American heart journal","volume":"278 ","pages":"Pages 170-180"},"PeriodicalIF":3.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renin angiotensin system inhibitors and outcome in patients with takotsubo syndrome: A propensity score analysis of the GEIST registry 肾素血管紧张素系统抑制剂与塔克次氏综合征患者的预后:GEIST 登记的倾向得分分析。
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-10 DOI: 10.1016/j.ahj.2024.08.019
Francesco Santoro MD, PhD , Thomas Stiermaier MD , Iván J. Núñez Gil MD, PhD , Ibrahim El-Battrawy MD , Toni Pätz MD , Luca Cacciotti MD, PhD , Federico Guerra MD , Giuseppina Novo MD, PhD , Beatrice Musumeci MD , Massimo Volpe MD , Enrica Mariano MD, PhD , Pasquale Caldarola MD , Roberta Montisci MD , Ilaria Ragnatela MD , Rosa Cetera MD , Ravi Vazirani MD , Carmen Lluch MD , Aitor Uribarri MD , Miguel Corbi-Pascual MD , David Aritza Conty Cardona MD , Luca Arcari MD

Background

Few data are available on long-term drug therapy and its potential prognostic impact after Takotsubo syndrome (TTS). Aim of the study is to evaluate clinical characteristics and long-term outcome of TTS patients on Renin Angiotensin system inhibitors (RASi).

Methods

TTS patients were enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry. Median follow-up was 31 (Interquartile range 12-56) months. Comparison of RASi treated vs. untreated patients was performed within the overall population and after 1:1 propensity score matching for age, sex, comorbidities, type of trigger and in-hospital complications.

Registration

clinicaltrials.gov, NCT04361994, https://clinicaltrials.gov/study/NCT04361994

Results

Of the 2453 TTS patients discharged alive, 1683 (68%) received RASi therapy. Patients with RASi were older (age 71 ± 11 vs 69 ± 13 years, P = .01), with higher prevalence of hypertension (74% vs 53%, P < .01) and diabetes (19% v s15%, P = .01), higher admission left ventricular ejection fraction (LVEF) (41 ± 11% vs 39 ± 12%, P < .01) and lower rates of in-hospital complications (18.9% vs 29.6%, P < .01). At multivariable analysis, RASi therapy at discharge was independently associated with lower mortality (HR 0.63, 95% CI 0.45-0.87, P < .01). Survival analysis showed that at long term, patients treated with RASi had lower mortality rates in the overall cohort (log-rank P = .001). However, this benefit was not found among patients treated with RASi in the matched cohort (log-rank P = .168). Potential survival benefit of RASi were present, both in the overall and matched cohort, in 2 subgroups: patients with admission LVEF ≤ 40% (HR 0.54 95% CI 0.38-0.78, P = .001; HR 0.59, 95% CI 0.37-0.95, P = .030) and diabetes (HR 0.41, 95% CI 0.23-0.73, P = .002; HR 0.41, 95% CI 0.21-0.82, P = .011).

Conclusions

Long-term therapy with RASi after a TTS episode was not associated with lower mortality rates at propensity score analysis. However, potential survival benefit can be found among patients with admission LVEF ≤ 40% or diabetes.
背景关于塔克次氏综合征(TTS)后长期药物治疗及其潜在预后影响的数据很少。本研究旨在评估服用肾素血管紧张素系统抑制剂(RASi)的 TTS 患者的临床特征和长期预后。中位随访时间为 31 个月(四分位距为 12-56 个月)。RASi治疗与未治疗患者的比较在总体人群中进行,并根据年龄、性别、合并症、触发类型和院内并发症进行1:1倾向评分匹配。REGISTRATIONclinicaltrials.gov, NCT04361994, https://clinicaltrials.gov/study/NCT04361994 结果:在2453名活着出院的TTS患者中,1683人(68%)接受了RASi治疗。接受RASi治疗的患者年龄较大(71±11岁 vs 69±13岁,P=0.01),高血压(74% vs 53%,P<0.01)和糖尿病(19% vs 15%,P=0.01)患病率较高,入院左室射血分数(LVEF)较高(41±11% vs 39±12%,P<0.01),院内并发症发生率较低(18.9% vs 29.6%,P<0.01)。在多变量分析中,出院时接受 RASi 治疗与较低的死亡率独立相关(HR 0.63,95%CI 0.45-0.87,p<0.01)。生存分析表明,从长期来看,接受RASi治疗的患者在整个队列中的死亡率较低(对数秩P=0.001)。然而,在配对队列中,接受 RASi 治疗的患者并没有发现这种益处(对数秩 P=0.168)。在总体队列和匹配队列中,RASi的潜在生存获益存在于两个亚组:入院时LVEF≤40%的患者(HR 0.54,95%CI 0.38-0.78,p=0.001;HR 0.59,95%CI 0.37-0.95,p=0.030)和糖尿病(HR 0.41,95%CI 0.23-0.73,p= 0.002;HR 0.41,95%CI 0.21-0.82,p=0.011)。结论TTS发作后长期使用RASi治疗与倾向评分分析中较低的死亡率无关。然而,入院时 LVEF ≤40% 或患有糖尿病的患者可能会获得生存益处。
{"title":"Renin angiotensin system inhibitors and outcome in patients with takotsubo syndrome: A propensity score analysis of the GEIST registry","authors":"Francesco Santoro MD, PhD ,&nbsp;Thomas Stiermaier MD ,&nbsp;Iván J. Núñez Gil MD, PhD ,&nbsp;Ibrahim El-Battrawy MD ,&nbsp;Toni Pätz MD ,&nbsp;Luca Cacciotti MD, PhD ,&nbsp;Federico Guerra MD ,&nbsp;Giuseppina Novo MD, PhD ,&nbsp;Beatrice Musumeci MD ,&nbsp;Massimo Volpe MD ,&nbsp;Enrica Mariano MD, PhD ,&nbsp;Pasquale Caldarola MD ,&nbsp;Roberta Montisci MD ,&nbsp;Ilaria Ragnatela MD ,&nbsp;Rosa Cetera MD ,&nbsp;Ravi Vazirani MD ,&nbsp;Carmen Lluch MD ,&nbsp;Aitor Uribarri MD ,&nbsp;Miguel Corbi-Pascual MD ,&nbsp;David Aritza Conty Cardona MD ,&nbsp;Luca Arcari MD","doi":"10.1016/j.ahj.2024.08.019","DOIUrl":"10.1016/j.ahj.2024.08.019","url":null,"abstract":"<div><h3>Background</h3><div>Few data are available on long-term drug therapy and its potential prognostic impact after Takotsubo syndrome (TTS). Aim of the study is to evaluate clinical characteristics and long-term outcome of TTS patients on Renin Angiotensin system inhibitors (RASi).</div></div><div><h3>Methods</h3><div>TTS patients were enrolled in the international multicenter GEIST (GErman Italian Spanish Takotsubo) registry. Median follow-up was 31 (Interquartile range 12-56) months. Comparison of RASi treated vs. untreated patients was performed within the overall population and after 1:1 propensity score matching for age, sex, comorbidities, type of trigger and in-hospital complications.</div></div><div><h3>Registration</h3><div>clinicaltrials.gov, NCT04361994, https://clinicaltrials.gov/study/NCT04361994</div></div><div><h3>Results</h3><div>Of the 2453 TTS patients discharged alive, 1683 (68%) received RASi therapy. Patients with RASi were older (age 71 ± 11 vs 69 ± 13 years, <em>P</em> = .01), with higher prevalence of hypertension (74% vs 53%, <em>P</em> &lt; .01) and diabetes (19% v s15%, <em>P</em> = .01), higher admission left ventricular ejection fraction (LVEF) (41 ± 11% vs 39 ± 12%, <em>P</em> &lt; .01) and lower rates of in-hospital complications (18.9% vs 29.6%, <em>P</em> &lt; .01). At multivariable analysis, RASi therapy at discharge was independently associated with lower mortality (HR 0.63, 95% CI 0.45-0.87, <em>P</em> &lt; .01). Survival analysis showed that at long term, patients treated with RASi had lower mortality rates in the overall cohort (log-rank <em>P</em> = .001). However, this benefit was not found among patients treated with RASi in the matched cohort (log-rank <em>P</em> = .168). Potential survival benefit of RASi were present, both in the overall and matched cohort, in 2 subgroups: patients with admission LVEF ≤ 40% (HR 0.54 95% CI 0.38-0.78, <em>P</em> = .001; HR 0.59, 95% CI 0.37-0.95, <em>P</em> = .030) and diabetes (HR 0.41, 95% CI 0.23-0.73, <em>P</em> = .002; HR 0.41, 95% CI 0.21-0.82, <em>P</em> = .011).</div></div><div><h3>Conclusions</h3><div>Long-term therapy with RASi after a TTS episode was not associated with lower mortality rates at propensity score analysis. However, potential survival benefit can be found among patients with admission LVEF ≤ 40% or diabetes.</div></div>","PeriodicalId":7868,"journal":{"name":"American heart journal","volume":"278 ","pages":"Pages 127-138"},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rule-based natural language processing to examine variation in worsening heart failure hospitalizations by age, sex, race and ethnicity, and left ventricular ejection fraction 通过基于规则的自然语言处理,研究不同年龄、性别、种族和民族以及左心室射血分数对心力衰竭恶化住院情况的影响。
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-07 DOI: 10.1016/j.ahj.2024.09.001
Matthew T. Mefford PhD , Andrew P. Ambrosy MD , Rong Wei MS , Chengyi Zheng PhD , Rishi V. Parikh MPH , Teresa N. Harrison SM , Ming-Sum Lee MD , Alan S. Go MD , Kristi Reynolds PhD

Background

Prior studies characterizing worsening heart failure events (WHFE) have been limited in using structured healthcare data from hospitalizations, and with little exploration of sociodemographic variation. The current study examined the impact of incorporating unstructured data to identify WHFE, describing age-, sex-, race and ethnicity-, and left ventricular ejection fraction (LVEF)-specific rates.

Methods

Adult members of Kaiser Permanente Southern California (KPSC) with a HF diagnosis between 2014 and 2018 were followed through 2019 to identify hospitalized WHFE. The main outcome was hospitalizations with a principal or secondary HF discharge diagnosis meeting rule-based Natural Language Processing (NLP) criteria for WHFE. In comparison, we examined hospitalizations with a principal discharge diagnosis of HF. Age-, sex-, and race and ethnicity-adjusted rates per 100 person-years (PY) were calculated among age, sex, race and ethnicity (non-Hispanic (NH) Asian/Pacific Islander [API], Hispanic, NH Black, NH White) and LVEF subgroups.

Results

Among 44,863 adults with HF, 10,560 (23.5%) had an NLP-defined, hospitalized WHFE. Adjusted rates (per 100 PY) of WHFE using NLP were higher compared to rates based only on HF principal discharge diagnosis codes (12.7 and 9.3, respectively), and this followed similar patterns among subgroups, with the highest rates among adults ≥75 years (16.3 and 11.2), men (13.2 and 9.7), and NH Black (16.9 and 14.3) and Hispanic adults (15.3 and 11.4), and adults with reduced LVEF (16.2 and 14.0). Using NLP disproportionately increased the perceived burden of WHFE among API and adults with mid-range and preserved LVEF.

Conclusion

Rule-based NLP improved the capture of hospitalized WHFE above principal discharge diagnosis codes alone. Applying standardized consensus definitions to EHR data may improve understanding of the burden of WHFE and promote optimal care overall and in specific sociodemographic groups.
背景:之前关于心衰恶化事件(WHFE)特征的研究仅限于使用住院治疗的结构化医疗数据,而且很少探讨社会人口学差异。本研究考察了纳入非结构化数据对识别心衰事件的影响,描述了年龄、性别、种族和民族以及左心室射血分数(LVEF)特异性比率。主要结果是主要或次要 HF 出院诊断符合基于规则的自然语言处理 (NLP) WHFE 标准的住院情况。相比之下,我们检查了主要出院诊断为 HF 的住院情况。在年龄、性别、种族和民族(非西班牙裔(NH)亚太岛民 [API]、西班牙裔、NH 黑人、NH 白人)以及 LVEF 亚组中,我们计算了经年龄、性别、种族和民族调整的每百人年(PY)发病率。结果在 44,863 名成人高频患者中,10,560 人(23.5%)有 NLP 定义的 WHFE 住院病例。与仅基于心房颤动主要出院诊断代码的 WHFE 率(分别为 12.7 和 9.3)相比,使用 NLP 的调整后 WHFE 率(每 100 PY)更高,而且亚组之间的模式相似,年龄≥75 岁的成人(16.3 和 11.2)、男性(13.2 和 9.7)、新罕布什尔州黑人(16.9 和 14.3)和西班牙裔成人(15.3 和 11.4)以及 LVEF 降低的成人(16.2 和 14.0)的 WHFE 率最高。结论基于规则的 NLP 提高了对住院 WHFE 的捕获率,超过了单纯的主要出院诊断代码。将标准化的共识定义应用于电子病历数据可提高对 WHFE 负担的认识,促进整体和特定社会人口群体的最佳护理。
{"title":"Rule-based natural language processing to examine variation in worsening heart failure hospitalizations by age, sex, race and ethnicity, and left ventricular ejection fraction","authors":"Matthew T. Mefford PhD ,&nbsp;Andrew P. Ambrosy MD ,&nbsp;Rong Wei MS ,&nbsp;Chengyi Zheng PhD ,&nbsp;Rishi V. Parikh MPH ,&nbsp;Teresa N. Harrison SM ,&nbsp;Ming-Sum Lee MD ,&nbsp;Alan S. Go MD ,&nbsp;Kristi Reynolds PhD","doi":"10.1016/j.ahj.2024.09.001","DOIUrl":"10.1016/j.ahj.2024.09.001","url":null,"abstract":"<div><h3>Background</h3><div>Prior studies characterizing worsening heart failure events (WHFE) have been limited in using structured healthcare data from hospitalizations, and with little exploration of sociodemographic variation. The current study examined the impact of incorporating unstructured data to identify WHFE, describing age-, sex-, race and ethnicity-, and left ventricular ejection fraction (LVEF)-specific rates.</div></div><div><h3>Methods</h3><div>Adult members of Kaiser Permanente Southern California (KPSC) with a HF diagnosis between 2014 and 2018 were followed through 2019 to identify hospitalized WHFE. The main outcome was hospitalizations with a principal or secondary HF discharge diagnosis meeting rule-based Natural Language Processing (NLP) criteria for WHFE. In comparison, we examined hospitalizations with a principal discharge diagnosis of HF. Age-, sex-, and race and ethnicity-adjusted rates per 100 person-years (PY) were calculated among age, sex, race and ethnicity (non-Hispanic (NH) Asian/Pacific Islander [API], Hispanic, NH Black, NH White) and LVEF subgroups.</div></div><div><h3>Results</h3><div>Among 44,863 adults with HF, 10,560 (23.5%) had an NLP-defined, hospitalized WHFE. Adjusted rates (per 100 PY) of WHFE using NLP were higher compared to rates based only on HF principal discharge diagnosis codes (12.7 and 9.3, respectively), and this followed similar patterns among subgroups, with the highest rates among adults ≥75 years (16.3 and 11.2), men (13.2 and 9.7), and NH Black (16.9 and 14.3) and Hispanic adults (15.3 and 11.4), and adults with reduced LVEF (16.2 and 14.0). Using NLP disproportionately increased the perceived burden of WHFE among API and adults with mid-range and preserved LVEF.</div></div><div><h3>Conclusion</h3><div>Rule-based NLP improved the capture of hospitalized WHFE above principal discharge diagnosis codes alone. Applying standardized consensus definitions to EHR data may improve understanding of the burden of WHFE and promote optimal care overall and in specific sociodemographic groups.</div></div>","PeriodicalId":7868,"journal":{"name":"American heart journal","volume":"278 ","pages":"Pages 117-126"},"PeriodicalIF":3.7,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocol for a randomized controlled trial of intensive blood pressure control on cardiovascular risk reduction in patients with atrial fibrillation: Rationale and design of the CRAFT trial 降低心房颤动患者心血管风险的强化血压控制随机对照试验方案:CRAFT 试验的原理与设计。
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-07 DOI: 10.1016/j.ahj.2024.08.008
Chao Jiang MD , Zhiyan Wang MD , Xin Du MD, PhD , Yufeng Wang MD , Mingyang Gao MD , Zhaoxu Jia MD , Zhongyi Chai MD , Zhiyun Yang MD , Chi Wang PhD , Liu He PhD , Rong Hu MD , Qiang Lv MD , Jiahui Wu MD , Xu Li MD , Changqi Jia MD , Rong Han ME , Hisatomi Arima MD, PhD , Xia Wang PhD , Bruce Neal MD, PhD , Anthony Rodgers MD, PhD , Changsheng Ma MD

Background

Co-morbid hypertension is strong predictor of adverse cardiovascular (CV) outcomes in patients with atrial fibrillation (AF) but the optimal target for blood pressure (BP) control in this patient population has not been clearly defined.

Methods

The Cardiovascular Risk reduction in patients with Atrial Fibrillation Trial (CRAFT) is an investigator-initiated and conducted, international, multicenter, open-label, parallel-group, blinded outcome assessed, randomized controlled trial of intensive BP control in patients with AF. The aim is to determine whether intensive BP control (target home systolic blood pressure [SBP] <120 mmHg) is superior to standard BP control (home SBP <135 mmHg) on the hierarchical composite outcome of time to CV death, number of stroke events, time to the first stroke, number of myocardial infarction (MI) events, time to the first MI, number of heart failure hospitalization (HFH) events, and time to the first HFH. A sample size of 1,675 patients is estimated to provide 80% power to detect a win-ratio of 1.50 for intensive versus standard BP control on the primary composite outcome. Study visits are conducted at 1, 2, 3, and 6 months postrandomization, and every 6 months thereafter during the study.

Conclusions

This clinical trial aims to provide reliable evidence of the effects of intensive BP control in patients with AF.

Trial registration

The trial is registered at ClinicalTrials.gov (NCT04347330)

背景:合并高血压是心房颤动(房颤)患者不良心血管(CV)结局的有力预测因素,但该患者群体的最佳血压(BP)控制目标尚未明确:心房颤动患者降低心血管风险试验(CRAFT)是一项由研究者发起并开展的国际多中心、开放标签、平行分组、盲法结果评估、随机对照试验,旨在对心房颤动患者进行强化血压控制。目的是确定强化血压控制(目标家庭收缩压[SBP] 结论)是否对心房颤动患者有效:这项临床试验旨在为房颤患者强化血压控制的效果提供可靠的证据。
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引用次数: 0
Information for Readers 读者信息
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-04 DOI: 10.1016/S0002-8703(24)00231-X
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引用次数: 0
Response to Tomoyuki Kawada: Blood and urine metal levels in patients with diabetes and cardiovascular disease 回应 Tomoyuki Kawada:糖尿病和心血管疾病患者血液和尿液中的金属水平
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-04 DOI: 10.1016/j.ahj.2024.07.004
Ana Navas-Acien MD, PhD , Daniel B. Mark MD, MPH , Kevin Anstrom PhD, MS , Gervasio A. Lamas MD
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引用次数: 0
Risk of cardiovascular events after influenza infection-related hospitalizations in adults with congenital heart disease: A nationwide population based study 先天性心脏病患者因流感感染住院后发生心血管事件的风险--一项基于全国人口的研究。
IF 3.7 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-04 DOI: 10.1016/j.ahj.2024.08.023
Masaki Kodaira MD , Mohammad Sazzad Hasan PhD , Yoni Grossman MD , Carlos Guerrero MD , Liming Guo MSc , Aihua Liu PhD , Judith Therrien MD, FRCPC , Ariane Marelli MD, MPH, FRCPC, FACC, FAHA

Background

Cardiovascular complications due to viral infection pose a significant risk in vulnerable patients such as those with congenital heart disease (CHD). Limited data exists regarding the incidence of influenza and its impact on cardiovascular outcomes among this specific patient population.

Methods

A retrospective cohort study was designed using the Canadian Congenital Heart Disease (CanCHD) database—a pan-Canadian database of CHD patients with up to 35 years of follow-up. CHD patients aged 40 to 65 years with influenza virus-associated hospitalizations between 2010 and 2017 were identified and 1:1 matched with CHD patients with limb fracture hospitalizations on age and calendar time. Our primary endpoint was cardiovascular complications: heart failure, acute myocardial infarction, atrial arrhythmia, ventricular arrhythmia, heart block, myocarditis, and pericarditis.

Results

Of the 303 patients identified with incident influenza virus-associated hospitalizations, 255 were matched to 255 patients with limb fracture hospitalizations. Patients with influenza virus-related hospitalizations showed significantly higher cumulative probability of cardiovascular complications at 1 year (0.16 vs. 0.03) and 5 years (0.33 vs. 0.15) compared to patients hospitalized with bone fracture. Time-dependent hazard function modeling demonstrated a significantly higher risk of cardiovascular complications within 9 months postdischarge for influenza-related hospitalizations. This association was confirmed by Cox regression model (average hazard ratio throughout follow-up: 2.48; 95% CI: 1.59-3.84).

Conclusions

This pan-Canadian cohort study of adults with CHD demonstrated an association between influenza virus-related hospitalization and risk of cardiovascular complications during the 9 months post discharge. This data is essential in planning surveillance strategies to mitigate adverse outcomes and provides insights into interpreting complication rates of other emerging pathogens, such as COVID-19.
背景:病毒感染导致的心血管并发症对先天性心脏病(CHD)患者等易感人群构成重大风险。有关流感发病率及其对这一特殊患者群体心血管后果影响的数据有限:我们利用加拿大先天性心脏病(CanCHD)数据库设计了一项回顾性队列研究,该数据库是一个泛加拿大先天性心脏病患者数据库,随访时间长达 35 年。研究人员对 2010 年至 2017 年期间因流感病毒住院的 40 岁至 65 岁先天性心脏病患者进行了鉴定,并根据年龄和日历时间与因肢体骨折住院的先天性心脏病患者进行了 1:1 匹配。我们的主要终点是心血管并发症:心力衰竭、急性心肌梗死、房性心律失常、室性心律失常、心脏传导阻滞、心肌炎和心包炎:在 303 例流感病毒相关住院患者中,有 255 例与 255 例肢体骨折住院患者相匹配。与骨折住院患者相比,流感病毒相关住院患者在一年(0.16 对 0.03)和五年(0.33 对 0.15)后出现心血管并发症的累积概率明显更高。时间依赖性危险函数模型显示,与流感相关的住院患者在出院后九个月内出现心血管并发症的风险明显更高。Cox回归模型证实了这一关联(整个随访期间的平均危险比:2.48;95% CI:1.59 - 3.84):这项针对患有冠心病的成年人的泛加拿大队列研究表明,流感病毒相关住院治疗与出院后九个月内心血管并发症风险之间存在关联。这些数据对于规划监测策略以减轻不良后果至关重要,并为解读 COVID-19 等其他新病原体的并发症发生率提供了启示。
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引用次数: 0
期刊
American heart journal
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