首页 > 最新文献

Annales de la Societe belge de medecine tropicale最新文献

英文 中文
[Diagnostic and therapeutic management of uncomplicated malaria attacks in the Dakar region, Senegal]. [塞内加尔达喀尔地区无并发症疟疾发作的诊断和治疗管理]。
E Feller-Dansokho, G Ki-Zerbo, S Badiane

A questionnaire survey was conducted in the Dakar region (Senegal) between August and October 1992 to investigate diagnosis and treatment practices for uncomplicated malaria attacks in the health care facilities. The sample consisted of 208 prescribers in the operational sense i.e. 20% of the following professional categories: medical doctors, health care technicians, birth attendants, qualified nurses, and auxiliary nurses. A thick smear was mentioned as a diagnostic element by 23% of the practitioners; chloroquine remained the first choice drug for 80% of the personnel but 13% declared prescribing parenteral quinine for uncomplicated malaria in patients without vomiting; halofantrine and the association sulfadoxine-pyrimethamine-mefloquine are prescribed by respectively 7 and 1% of the personnel, also in the public sector; chloroquine is prescribed in an effective dose (25-40 mg/kg) by 74% of the personnel for adults and by 43% for children; quinine base in a dose below 25 mg/kg by 100% of personnel for adults and by 99% for children; nearly half of the prescribers do not take into account the children's weight; 13% of the practitioners prescribe useless expensive symptomatic treatments and 45 to 73% ignore the price of the common antimalarials, allowing for a 10% error; health care workers have a bad knowledge of the results of chemosensitivity surveys. The development of a national malaria control programme that emphasises permanent training of the health care workers and control of therapeutic information seems mandatory.

1992年8月至10月期间在达喀尔地区(塞内加尔)进行了一项问卷调查,以调查保健设施对无并发症的疟疾发作的诊断和治疗做法。样本包括208名操作意义上的处方者,即以下专业类别的20%:医生、卫生保健技术人员、助产士、合格护士和辅助护士。23%的医生认为厚涂片是一种诊断因素;80%的医务人员仍将氯喹作为首选药物,但13%的医务人员表示,对于无呕吐的无并发症疟疾患者,他们会开非肠外奎宁;同样在公共部门,分别有7%和1%的工作人员开具卤化茴香碱和磺胺多辛-乙胺嘧啶-甲氟喹;74%的成人和43%的儿童按有效剂量(25-40 mg/kg)开具氯喹处方;100%成人和99%儿童的奎宁基础剂量低于25 mg/kg;将近一半的开处方者没有考虑到儿童的体重;13%的从业人员开出无用的昂贵对症治疗处方,45%至73%的人忽略了常见抗疟药的价格,从而导致10%的误差;卫生保健工作者对化学敏感性调查的结果知之甚少。制定一项国家疟疾控制方案,强调对保健工作人员的长期培训和对治疗信息的控制,似乎是必须的。
{"title":"[Diagnostic and therapeutic management of uncomplicated malaria attacks in the Dakar region, Senegal].","authors":"E Feller-Dansokho,&nbsp;G Ki-Zerbo,&nbsp;S Badiane","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A questionnaire survey was conducted in the Dakar region (Senegal) between August and October 1992 to investigate diagnosis and treatment practices for uncomplicated malaria attacks in the health care facilities. The sample consisted of 208 prescribers in the operational sense i.e. 20% of the following professional categories: medical doctors, health care technicians, birth attendants, qualified nurses, and auxiliary nurses. A thick smear was mentioned as a diagnostic element by 23% of the practitioners; chloroquine remained the first choice drug for 80% of the personnel but 13% declared prescribing parenteral quinine for uncomplicated malaria in patients without vomiting; halofantrine and the association sulfadoxine-pyrimethamine-mefloquine are prescribed by respectively 7 and 1% of the personnel, also in the public sector; chloroquine is prescribed in an effective dose (25-40 mg/kg) by 74% of the personnel for adults and by 43% for children; quinine base in a dose below 25 mg/kg by 100% of personnel for adults and by 99% for children; nearly half of the prescribers do not take into account the children's weight; 13% of the practitioners prescribe useless expensive symptomatic treatments and 45 to 73% ignore the price of the common antimalarials, allowing for a 10% error; health care workers have a bad knowledge of the results of chemosensitivity surveys. The development of a national malaria control programme that emphasises permanent training of the health care workers and control of therapeutic information seems mandatory.</p>","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 4","pages":"291-300"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18729150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cerebral malaria in children in Yaounde, Cameroon. Clinical, paraclinical and developmental aspects]. 喀麦隆雅温得儿童患脑疟疾。临床、准临床和发育方面]。
P F Tchokoteu, D Poka, A Same Ekobo, J Ngogang, I Kago, F Tietche, P Doumbe, E Mbonda, P Koki Ndombo, E Tetanye

Cerebral malaria is one of the major and deadly complications of malaria. In Cameroon, recent reports indicate that severe cases of malaria are increasingly more prevalent, particularly in children. The present study aims at describing the clinical presentation and laboratory findings of cerebral malaria in children in Yaounde. All patients admitted in the paediatric ward of Yaounde Central Hospital with malaria, who presented neurological signs and were tested positive for Plasmodium in their peripheral blood were recruited into the study. 36 cases were enrolled in all, making up 2.7% of all admissions. The patients' median age was 4.5 years. 52.8% were on malaria prophylaxis. Convulsions and coma with preceding hyperthermia were present in more than 90% of the patients. Blood parasites level median was 1.3% on admission. One patient had hypoglycaemia on admission and two others had it later on after admission; 16.7% had neurological sequels at discharge and two children died (5.6%). Delay in diagnosis and initiation of treatment with quinine adversely affected the prognosis of cerebral malaria in the study group.

脑型疟疾是疟疾的主要和致命并发症之一。在喀麦隆,最近的报告表明,严重疟疾病例越来越普遍,特别是在儿童中。本研究旨在描述雅温得儿童脑疟疾的临床表现和实验室结果。雅温得中心医院儿科病房收治的所有疟疾患者均被纳入研究,这些患者出现神经系统症状,外周血中疟原虫检测呈阳性。共纳入36例,占总入学率的2.7%。患者的中位年龄为4.5岁。接受疟疾预防的占52.8%。90%以上的患者存在惊厥和昏迷并伴有热疗。入院时血液寄生虫水平中位数为1.3%。一名患者入院时出现低血糖,另外两名患者入院后出现低血糖;出院时有神经系统后遗症(16.7%),2例死亡(5.6%)。在研究组中,延迟诊断和开始使用奎宁治疗对脑型疟疾的预后有不利影响。
{"title":"[Cerebral malaria in children in Yaounde, Cameroon. Clinical, paraclinical and developmental aspects].","authors":"P F Tchokoteu,&nbsp;D Poka,&nbsp;A Same Ekobo,&nbsp;J Ngogang,&nbsp;I Kago,&nbsp;F Tietche,&nbsp;P Doumbe,&nbsp;E Mbonda,&nbsp;P Koki Ndombo,&nbsp;E Tetanye","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cerebral malaria is one of the major and deadly complications of malaria. In Cameroon, recent reports indicate that severe cases of malaria are increasingly more prevalent, particularly in children. The present study aims at describing the clinical presentation and laboratory findings of cerebral malaria in children in Yaounde. All patients admitted in the paediatric ward of Yaounde Central Hospital with malaria, who presented neurological signs and were tested positive for Plasmodium in their peripheral blood were recruited into the study. 36 cases were enrolled in all, making up 2.7% of all admissions. The patients' median age was 4.5 years. 52.8% were on malaria prophylaxis. Convulsions and coma with preceding hyperthermia were present in more than 90% of the patients. Blood parasites level median was 1.3% on admission. One patient had hypoglycaemia on admission and two others had it later on after admission; 16.7% had neurological sequels at discharge and two children died (5.6%). Delay in diagnosis and initiation of treatment with quinine adversely affected the prognosis of cerebral malaria in the study group.</p>","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"193-202"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis C virus antibody, viraemia and genotypes in individuals infected with HIV-1 in Cameroon. 喀麦隆HIV-1感染者的丙型肝炎病毒抗体、病毒血症和基因型
J N Nkengasong, H Claeys, H De Beenhouwer, L Heyndrickxs, J Ayuk, V Lobe, P Ndumbe
{"title":"Hepatitis C virus antibody, viraemia and genotypes in individuals infected with HIV-1 in Cameroon.","authors":"J N Nkengasong,&nbsp;H Claeys,&nbsp;H De Beenhouwer,&nbsp;L Heyndrickxs,&nbsp;J Ayuk,&nbsp;V Lobe,&nbsp;P Ndumbe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"249-52"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18538642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New ways in public health? 公共卫生的新方法?
K Vuylsteek
{"title":"New ways in public health?","authors":"K Vuylsteek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"173-6"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Aspects of the enzymatic evaluation in Plasmodium falciparum malaria infection]. [恶性疟原虫疟疾感染的酶促评价方面]。
N Ngangoue

To try to find effects of malaria on clinical serum activity of certain enzymes, 3 groups of infants--malarial, asymptomatic carrier and normal controls--have been designed. Parasitologic data have been compared with serum concentration of lactate dehydrogenase (LDH), Hydroxybutyrate dehydrogenase (HBDH) alanine aminotransferase (ALT), gamma glutamyl transferase (GGT) and 5'nucleotidase (5'Nu). Results show that only LDH and HBDH are significantly increased. Respective coefficients of correlation r = 0.32 (p < 0.05) and r = 0.39 (p < 0.01) show that increasing in LDH and HBDH are linked to malarial parasite density. LDH and HBDH increasing might therefore constitute a marker of malaria.

为了试图发现疟疾对某些酶的临床血清活性的影响,设计了三组婴儿——疟疾、无症状携带者和正常对照。将寄生虫学资料与血清乳酸脱氢酶(LDH)、羟丁酸脱氢酶(HBDH)、丙氨酸转氨酶(ALT)、谷氨酰基转移酶(GGT)和5′核苷酸酶(5′nu)浓度进行比较。结果显示,只有LDH和HBDH显著升高。相关系数r = 0.32 (p < 0.05)和r = 0.39 (p < 0.01)表明LDH和HBDH的升高与疟原虫密度有关。因此,LDH和HBDH升高可能是疟疾的一个标志。
{"title":"[Aspects of the enzymatic evaluation in Plasmodium falciparum malaria infection].","authors":"N Ngangoue","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To try to find effects of malaria on clinical serum activity of certain enzymes, 3 groups of infants--malarial, asymptomatic carrier and normal controls--have been designed. Parasitologic data have been compared with serum concentration of lactate dehydrogenase (LDH), Hydroxybutyrate dehydrogenase (HBDH) alanine aminotransferase (ALT), gamma glutamyl transferase (GGT) and 5'nucleotidase (5'Nu). Results show that only LDH and HBDH are significantly increased. Respective coefficients of correlation r = 0.32 (p < 0.05) and r = 0.39 (p < 0.01) show that increasing in LDH and HBDH are linked to malarial parasite density. LDH and HBDH increasing might therefore constitute a marker of malaria.</p>","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"187-92"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing number of AIDS cases, mostly caused by HIV-1 infection, in Dakar (Senegal). 在达喀尔(塞内加尔),越来越多的艾滋病病例,主要是由HIV-1感染引起的。
P S Sow, M A Faye, B M Diop, G Diouf, R Colebunders, A M Coll-Seck
{"title":"Increasing number of AIDS cases, mostly caused by HIV-1 infection, in Dakar (Senegal).","authors":"P S Sow,&nbsp;M A Faye,&nbsp;B M Diop,&nbsp;G Diouf,&nbsp;R Colebunders,&nbsp;A M Coll-Seck","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"253-5"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Dengue 1 epidemic in the Grand Comoro Island (Federal Islamic Republic of the Comores). March-May 1993]. [大科摩罗岛(科摩罗伊斯兰联邦共和国)的登革热流行]。高于1993]。
P Boisier, J M Morvan, S Laventure, N Charrier, E Martin, A Ouledi, J Roux

An epidemic of dengue fever occurred in Grande Comore island from March to May 1993. Dengue 1 virus has been isolated. The epidemic did not affect the other islands of the archipelago. No compound clinical picture, in particular hemorrhagic, was reported. A random sampling survey conducted towards the end of April showed that 26% of the population aged 5 years old or more had IgM dengue antibodies. The epidemic concerned essentially individuals under 45 years of age. The number of inhabitants of Grande Comore affected by the outbreak can be estimated between 56,000 and 75,000. The results of the sero-epidemiological survey allowed to find the serological scar of two previous epidemics of dengue: the first one around 1948, which may correspond with dengue 1, the other one in 1984, probably with dengue 2.

1993年3月至5月,大科摩罗岛发生了登革热流行病。已分离出1型登革热病毒。这种流行病没有影响到该群岛的其他岛屿。无复合临床表现,特别是出血,报告。4月底进行的随机抽样调查显示,26%的5岁或5岁以上人口有IgM登革热抗体。这种流行病主要涉及45岁以下的个人。受疫情影响的大科摩罗居民人数估计在56 000至75 000之间。血清流行病学调查的结果发现了以前两次登革热流行的血清学疤痕:第一次是在1948年左右,可能与登革热1型相对应,另一次是在1984年,可能与登革热2型相对应。
{"title":"[Dengue 1 epidemic in the Grand Comoro Island (Federal Islamic Republic of the Comores). March-May 1993].","authors":"P Boisier,&nbsp;J M Morvan,&nbsp;S Laventure,&nbsp;N Charrier,&nbsp;E Martin,&nbsp;A Ouledi,&nbsp;J Roux","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An epidemic of dengue fever occurred in Grande Comore island from March to May 1993. Dengue 1 virus has been isolated. The epidemic did not affect the other islands of the archipelago. No compound clinical picture, in particular hemorrhagic, was reported. A random sampling survey conducted towards the end of April showed that 26% of the population aged 5 years old or more had IgM dengue antibodies. The epidemic concerned essentially individuals under 45 years of age. The number of inhabitants of Grande Comore affected by the outbreak can be estimated between 56,000 and 75,000. The results of the sero-epidemiological survey allowed to find the serological scar of two previous epidemics of dengue: the first one around 1948, which may correspond with dengue 1, the other one in 1984, probably with dengue 2.</p>","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"217-29"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A highly efficient in vitro cloning procedure for asexual erythrocytic forms of the human malaria parasite Plasmodium falciparum. 人类疟原虫恶性疟原虫的无性红细胞形式的高效体外克隆程序。
G François, L Hendrix, M Wery

A very reliable and productive technique for cloning of Plasmodium falciparum in vitro is proposed, as demonstrated by successive limiting dilution of suspensions of asexual erythrocytic forms of the NF 54 strain. The introduction and the study of reliable clones is of extreme importance for a better understanding of the behaviour of the parasite, also in field conditions. The method is rapid, simple and efficient. The growth of the clones was individually monitored and the culture conditions were constantly adjusted during their stay in recipients of increasing size. A yield of 18/96 (18.75%) of provisional clones was obtained, while the supercloning phase resulted in 16/80 (20%) positive cultures. The probability that the latter were derived from a single progenitor is very high (99%). It was shown that three randomly selected clones (A1A9, A1B11, and A1C10) have excellent growth characteristics before and after cryopreservation, and after a longer period of culture in standard conditions.

提出了一种非常可靠和高效的体外克隆恶性疟原虫的技术,通过对无性红细胞形式的nf54菌株的连续极限稀释证明了这一点。引进和研究可靠的无性系对于更好地了解寄生虫的行为,以及在野外条件下的行为,具有极端重要的意义。该方法快速、简便、高效。在不断增加的受体中,对克隆的生长进行单独监测,并不断调整培养条件。临时无性系的产量为18/96(18.75%),超无性系的阳性培养率为16/80(20%)。后者来自单一祖先的可能性非常高(99%)。结果表明,随机选择的3个无性系(A1A9、A1B11和A1C10)在冷冻保存前后和标准条件下较长时间培养后均具有良好的生长特性。
{"title":"A highly efficient in vitro cloning procedure for asexual erythrocytic forms of the human malaria parasite Plasmodium falciparum.","authors":"G François,&nbsp;L Hendrix,&nbsp;M Wery","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A very reliable and productive technique for cloning of Plasmodium falciparum in vitro is proposed, as demonstrated by successive limiting dilution of suspensions of asexual erythrocytic forms of the NF 54 strain. The introduction and the study of reliable clones is of extreme importance for a better understanding of the behaviour of the parasite, also in field conditions. The method is rapid, simple and efficient. The growth of the clones was individually monitored and the culture conditions were constantly adjusted during their stay in recipients of increasing size. A yield of 18/96 (18.75%) of provisional clones was obtained, while the supercloning phase resulted in 16/80 (20%) positive cultures. The probability that the latter were derived from a single progenitor is very high (99%). It was shown that three randomly selected clones (A1A9, A1B11, and A1C10) have excellent growth characteristics before and after cryopreservation, and after a longer period of culture in standard conditions.</p>","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"177-85"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Control of Trypanosoma gambiense trypanosomiasis. Evaluation of a strategy based on the treatment of serologically suspected cases with a single dose of diminazene]. 冈比亚锥虫病的控制。以单剂量地咪那纳治疗血清学上疑似病例为基础的策略评价]。
H Bruneel, A van den Eeckhout, D Molisho, J Burke, D Degroof, J Pépin

A novel method for the control of T.b. gambiense trypanosomiasis was evaluated in an endemic focus of Zaïre where a high incidence had persisted despite massive participation in active case-finding surveys based on lymph node puncture. All inhabitants of 3 villages were examined with a card agglutination serological test (CATT), and parasitological examinations were performed on those who were CATT+. Individuals in whom we detected trypanosomes were treated as usual. A lumbar puncture was carried out on CATT+/parasitology- subjects; those whose cerebrospinal fluid showed more than 3 white blood cell (WBC) per mm3 were treated with a full course of melarsoprol while those with a CSF WBC count between 1 and 3 per mm3 were given a single injection of diminazene (7 mg/kg). Three such surveys were performed, with a 6-month interval, during which 282 "serological suspects" received diminazene, 39 "clinical cases" were given melarsoprol and 82 "parasitological cases" were treated according to standard protocols. The annual incidence of trypanosomiasis decreased rapidly from 10.4-41.1/1.000 inhabitants (mean: 17.6/1.000) during the 10 years before the intervention to 1.1-2.6/1.000 (mean: 1.7/1.000) in the 3 years following the intervention. No major adverse effect was seen with diminazene. Among the 282 serological suspects, an elevated CSF WBC count was later documented in 12 individuals, who were all cured with melarsoprol. The incidence increased 5 years after the intervention (7.1/1.000 in 1992), which may have been avoided had we carried out similar interventions in adjacent foci.

一种控制冈比亚锥虫病的新方法在Zaïre的一个地方性焦点进行了评估,尽管大量参与了基于淋巴结穿刺的主动病例发现调查,但该地区的高发病率仍然存在。对3个村的所有居民进行卡凝集血清学试验(CATT),对CATT阳性者进行寄生虫学检查。我们检测到锥虫的个体照常处理。对CATT+/寄生虫学组进行腰椎穿刺;脑脊液白细胞(WBC)每mm3大于3的患者接受全疗程的美拉胂醇治疗,而脑脊液白细胞计数在1至3 / mm3之间的患者接受单次注射(7 mg/kg)。进行了三次这样的调查,间隔6个月,在此期间,282名“血清学疑似病例”接受了迪米那,39名“临床病例”接受了美拉胂醇,82名“寄生虫病例”根据标准方案接受了治疗。在干预前10年,锥虫病的年发病率从10.4-41.1/ 1000人(平均17.6/ 1000人)迅速下降到干预后3年的1.1-2.6/ 1000人(平均1.7/ 1000人)。没有观察到咪唑烯的主要不良反应。在282例血清学疑似病例中,12例经美拉胂醇治疗后发现脑脊液白细胞计数升高。干预后5年发病率增加(1992年为7.1/ 1000),如果我们对邻近病灶进行类似的干预,这是可以避免的。
{"title":"[Control of Trypanosoma gambiense trypanosomiasis. Evaluation of a strategy based on the treatment of serologically suspected cases with a single dose of diminazene].","authors":"H Bruneel,&nbsp;A van den Eeckhout,&nbsp;D Molisho,&nbsp;J Burke,&nbsp;D Degroof,&nbsp;J Pépin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A novel method for the control of T.b. gambiense trypanosomiasis was evaluated in an endemic focus of Zaïre where a high incidence had persisted despite massive participation in active case-finding surveys based on lymph node puncture. All inhabitants of 3 villages were examined with a card agglutination serological test (CATT), and parasitological examinations were performed on those who were CATT+. Individuals in whom we detected trypanosomes were treated as usual. A lumbar puncture was carried out on CATT+/parasitology- subjects; those whose cerebrospinal fluid showed more than 3 white blood cell (WBC) per mm3 were treated with a full course of melarsoprol while those with a CSF WBC count between 1 and 3 per mm3 were given a single injection of diminazene (7 mg/kg). Three such surveys were performed, with a 6-month interval, during which 282 \"serological suspects\" received diminazene, 39 \"clinical cases\" were given melarsoprol and 82 \"parasitological cases\" were treated according to standard protocols. The annual incidence of trypanosomiasis decreased rapidly from 10.4-41.1/1.000 inhabitants (mean: 17.6/1.000) during the 10 years before the intervention to 1.1-2.6/1.000 (mean: 1.7/1.000) in the 3 years following the intervention. No major adverse effect was seen with diminazene. Among the 282 serological suspects, an elevated CSF WBC count was later documented in 12 individuals, who were all cured with melarsoprol. The incidence increased 5 years after the intervention (7.1/1.000 in 1992), which may have been avoided had we carried out similar interventions in adjacent foci.</p>","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"203-15"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of the use of diagnostic/treatment algorithms in the health centers of North Cameroon]. [对喀麦隆北部保健中心使用诊断/治疗算法的评估]。
F Haegeman, J L Ledecq, A Wyffels, K Dama

In February 1993, four years after their introduction, an assessment was made of the use of clinical flow charts (algorithms) by 16 nurses in charge of primary medical health centers in Northern Cameroon (Diamare Division, Far North Province). A study of the knowledge, attitude and behaviour of the nurses shows the flow charts to be appreciated as a tool for diagnostic aid and for professional training. 11 nurses report an initial systematic use of the flow charts. This associates with the observation of good skills in using the charts, observed among 10 of the nurses, and also with treatment standardisation. Problems in reading the flow charts correctly hinder their systematic use in diagnostic decision making. A retrospective analysis of 800 treatment prescriptions noted in the consultation registers, shows an average rate of treatment standardisation of 75%, varying from 52 to 98% among the different health centers. Three quarters of non standardised treatment is ineffective or inefficient. Specific training is using the flow charts, given in the form of a 4 day seminar to 7 of the nurses concerned, showed no better results, after 4 years, than those obtained during a practical training session of a global nature, taking place in a functional health centre. Basic professional training, as well as previous professional experience influences the performances of the nurses. This study confirms the need to introduce rationalisation in the prescription of treatment, and shows the importance of verifying practical user skills at the end of specific training sessions. It would be advisable to include the principles of clinical algorithms in the teaching programs of medical schools.

1993年2月,在采用算法四年后,对喀麦隆北部(远北省Diamare区)负责初级医疗保健中心的16名护士对临床流程图(算法)的使用情况进行了评估。一项对护士的知识、态度和行为的研究表明,流程图可以作为诊断援助和专业培训的工具。11名护士报告了初步系统使用流程图的情况。这与观察到的使用图表的良好技能有关,在10名护士中观察到,也与治疗标准化有关。正确阅读流程图的问题阻碍了流程图在诊断决策中的系统应用。对会诊登记簿中记录的800个治疗处方进行回顾性分析,结果显示,治疗标准化的平均比率为75%,不同保健中心的标准化比率从52%到98%不等。四分之三的非标准化治疗无效或效率低下。具体的培训是使用流程图,以为期4天的研讨会的形式对7名有关护士进行培训,4年后的结果并不比在功能性保健中心进行的全球性实际培训所取得的结果更好。基础的专业训练,以及以往的专业经验影响护士的表现。这项研究证实有必要使治疗处方合理化,并显示在具体培训课程结束时核查实际使用者技能的重要性。将临床算法原理纳入医学院校的教学方案是可取的。
{"title":"[Evaluation of the use of diagnostic/treatment algorithms in the health centers of North Cameroon].","authors":"F Haegeman,&nbsp;J L Ledecq,&nbsp;A Wyffels,&nbsp;K Dama","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In February 1993, four years after their introduction, an assessment was made of the use of clinical flow charts (algorithms) by 16 nurses in charge of primary medical health centers in Northern Cameroon (Diamare Division, Far North Province). A study of the knowledge, attitude and behaviour of the nurses shows the flow charts to be appreciated as a tool for diagnostic aid and for professional training. 11 nurses report an initial systematic use of the flow charts. This associates with the observation of good skills in using the charts, observed among 10 of the nurses, and also with treatment standardisation. Problems in reading the flow charts correctly hinder their systematic use in diagnostic decision making. A retrospective analysis of 800 treatment prescriptions noted in the consultation registers, shows an average rate of treatment standardisation of 75%, varying from 52 to 98% among the different health centers. Three quarters of non standardised treatment is ineffective or inefficient. Specific training is using the flow charts, given in the form of a 4 day seminar to 7 of the nurses concerned, showed no better results, after 4 years, than those obtained during a practical training session of a global nature, taking place in a functional health centre. Basic professional training, as well as previous professional experience influences the performances of the nurses. This study confirms the need to introduce rationalisation in the prescription of treatment, and shows the importance of verifying practical user skills at the end of specific training sessions. It would be advisable to include the principles of clinical algorithms in the teaching programs of medical schools.</p>","PeriodicalId":7901,"journal":{"name":"Annales de la Societe belge de medecine tropicale","volume":"74 3","pages":"231-47"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annales de la Societe belge de medecine tropicale
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1