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Web Exclusive. Annals Video Summary - Impact of Genomic Classifiers on Risk Stratification and Treatment Intensity in Patients With Localized Prostate Cancer. 基因组分类对局限性前列腺癌患者风险分层和治疗强度的影响。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.7326/ANNALS-24-03632-VS
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引用次数: 0
Web Exclusive. Annals Graphic Medicine - Passages.
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 Epub Date: 2025-02-11 DOI: 10.7326/ANNALS-24-00684-GM
Ankit Mehta
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引用次数: 0
Web Exclusive. Annals Consult Guys - Care of Patients With Low Cardiac Risk but Incidental Coronary Artery Calcification.
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 DOI: 10.7326/ANNALS-25-00667-CG
Howard H Weitz, Geno J Merli
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引用次数: 0
Web Exclusive. Annals On Call - Teaching Diagnostic Reasoning.
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 DOI: 10.7326/ANNALS-25-00438-OC
Robert M Centor, Rabih Geha, Reza Manesh
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引用次数: 0
The Nuances of Performance Measurement and Clinical Guidelines. 性能测量和临床指南的细微差别。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 Epub Date: 2024-12-31 DOI: 10.7326/ANNALS-24-02092
Amir Qaseem, Caroline L Goldzweig, Karen Campos, Brook Watts, Elisa I Choi, Samantha Tierney, Nick Fitterman, Rebecca A Andrews, Rebecca A Andrews, Caroline L Goldzweig, Nick Fitterman, Peter Basch, Elisa I Choi, Roger Chou, Roger S Khetan, Scott T MacDonald, Nancy L Miller, Cristin A Mount, Rhea E Powell, Nicole J Van Groningen, Brook Watts
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引用次数: 0
Effectiveness of Synchronous Postdischarge Contacts on Health Care Use and Patient Satisfaction : A Systematic Review and Meta-analysis. 同步出院后接触对医疗服务使用和患者满意度的影响:系统回顾和荟萃分析。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 Epub Date: 2025-01-14 DOI: 10.7326/ANNALS-24-01140
Joel C Boggan, Spoorthi Sankineni, Paul A Dennis, Dazhe Chen, Tina Wong Sledge, David Halpern, Sharron Rushton, John W Williams, Tatyana Der, Amir Alishahi Tabriz, Adelaide M Gordon, Morgan Jacobs, Nathan A Boucher, Maria Colandrea, Anastasia-Stefania Alexopoulos, Joanne Roman Jones, Nina Leflore-Lloyd, Sarah Cantrell, Karen M Goldstein, Jennifer M Gierisch

Background: Postdischarge contacts (PDCs) after hospitalization are common practice, but their effectiveness in reducing use of acute care after discharge remains unclear.

Purpose: To assess the effects of PDC on 30-day emergency department (ED) visits, 30-day hospital readmissions, and patient satisfaction.

Data sources: MEDLINE, Embase, and CINAHL searched from 2012 to 25 May 2023.

Study selection: Randomized and nonrandomized trials of PDC within 7 days.

Data extraction: Two investigators independently screened articles and assessed risk of bias (ROB). Single reviewers extracted data, with verification by second investigators. Random-effects meta-analyses were done on outcomes shared by at least 3 studies, and the certainty of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework.

Data synthesis: Of 13 included studies (11 randomized trials [RTs]), 12 delivered PDCs via telephone. Three of 11 RTs were rated as having low ROB, with 1 rated high. Most PDC interventions (n = 10) consisted of single telephone contacts, often within 3 days. Eight studies focused on patients identified as higher-risk by the authors. There were no differences in 30-day ED use (5 RTs; 3054 patients; risk difference, 0.00 [95% CI, -0.02 to 0.03]; moderate certainty) or 30-day hospital readmissions (7 RTs; 7075 patients; risk difference, 0.00 [CI, -0.02 to 0.02]; moderate certainty) with PDC.

Limitation: Adherence and fidelity to PDC interventions were poorly described, and only 1 study investigated nontelephone PDC.

Conclusion: Postdischarge contacts within 7 days of discharge were not associated with reductions in 30-day ED use or readmissions compared with usual care. Health systems should reconsider the utility of universal PDCs because multifaceted interventions targeting higher-risk patients may be necessary to reduce use of acute care after discharge.

Primary funding source: Department of Veterans Affairs. (PROSPERO: CRD42023465675).

背景:住院后的出院后接触(PDCs)是常见的做法,但其在减少出院后急性护理使用方面的有效性尚不清楚。目的:评价PDC对30天急诊科(ED)就诊次数、30天再入院率和患者满意度的影响。数据来源:MEDLINE, Embase和CINAHL检索自2012年至2023年5月25日。研究选择:7天内PDC的随机和非随机试验。数据提取:两名研究者独立筛选文章并评估偏倚风险(ROB)。单个审稿人提取数据,并由第二个调查人员进行验证。对至少3项研究共享的结果进行随机效应荟萃分析,并使用GRADE(建议评估、发展和评价分级)框架评估证据的确定性。数据综合:在13项纳入的研究(11项随机试验[RTs])中,12项通过电话提供PDCs。11个RTs中有3个被评为低ROB, 1个被评为高ROB。大多数PDC干预(n = 10)包括单次电话接触,通常在3天内进行。八项研究的重点是被作者确定为高风险的患者。30天ED使用无差异(5 RTs;3054例;风险差异为0.00 [95% CI, -0.02 ~ 0.03];中等确定性)或30天的再入院(7个RTs;7075例;风险差为0.00 [CI, -0.02 ~ 0.02];中等确定性)。局限性:对PDC干预措施的依从性和保真度描述不佳,只有1项研究调查了非电话PDC。结论:与常规护理相比,出院后7天内的接触与30天ED使用或再入院的减少无关。卫生系统应重新考虑通用pdc的效用,因为针对高风险患者的多方面干预可能是减少出院后急诊使用的必要条件。主要资金来源:退伍军人事务部。(普洛斯彼罗:CRD42023465675)。
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引用次数: 0
Germline UBA1 Variant With Somatic Amplification in a Woman With Inflammatory Diseases and Myelodysplastic Syndrome. 炎性疾病和骨髓增生异常综合征女性的生殖系UBA1变异与体细胞扩增
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.7326/L24-0125
Maria Creignou, Maria Sirenko, Pedro L Moura, Teresa Mortera-Blanco, Marios Dimitriou, Birgitta Sander, Dylan Domenico, Juan E Arango Ossa, Bianca Tesi, David B Beck, Petter Woll, Sten-Eirik W Jacobsen, Elli Papaemmanuil, Elsa Bernard, Eva Hellström-Lindberg
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引用次数: 0
Hemochromatosis.
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 Epub Date: 2025-02-11 DOI: 10.7326/ANNALS-24-03710
William C Palmer, Fernando F Stancampiano

Hemochromatosis is an inheritable condition that mainly affects White populations of European descent. Most patients remain asymptomatic, but others develop advanced organ damage that reduces quality of life and long-term survival. Arthropathy, diabetes mellitus, cirrhosis, hypogonadotropic hypogonadism, and cardiomyopathy are key clinical manifestations. Primary care and hospital medicine physicians play an essential role in early identification of this disease, which can be accomplished via standard hematologic testing. Early diagnosis and therapeutic phlebotomy improve clinical outcomes.

血色沉着病是一种主要影响欧洲裔白人的遗传性疾病。大多数患者没有症状,但也有一些患者会出现晚期器官损伤,从而降低生活质量和长期存活率。关节病、糖尿病、肝硬化、性腺功能减退症和心肌病是主要的临床表现。初级保健和医院内科医生在早期识别这种疾病方面起着至关重要的作用,可以通过标准的血液学检测来实现。早期诊断和治疗性抽血可改善临床疗效。
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引用次数: 0
Summary for Patients: Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes.
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI: 10.7326/ANNALS-24-01590-PS
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引用次数: 0
In adults with obesity and knee OA, adding weekly semaglutide to diet and activity counseling reduced weight and knee pain at 68 wk.
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-01 Epub Date: 2025-02-04 DOI: 10.7326/ANNALS-24-03988-JC
David S H Bell

Clinical impact ratings: GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text] Rheumatology: [Formula: see text].

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引用次数: 0
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