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Relaxing Transfusion Thresholds for Patients With Myocardial Infarction: Findings From the MINT Trial. 放宽心肌梗死患者的输血阈值:MINT 试验结果。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI: 10.7326/M24-0895
Evan M Bloch, Aaron A R Tobian
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引用次数: 0
Web Exclusive. Annals On Call - Kratom: A Substance Physicians Should Be Aware Of. Annals On Call - Kratom:医生应了解的一种物质。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.7326/ANNALS-24-03271-OC
Robert M Centor, Eileen D Barrett, Amanda L Collar
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引用次数: 0
In subclinical AF, the benefit of apixaban vs. aspirin on stroke or systemic embolism trended higher with CHA2DS2-VASc >4. 在亚临床房颤患者中,如果 CHA2DS2-VASc >4,阿哌沙班与阿司匹林相比对中风或全身性栓塞的益处呈上升趋势。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.7326/ANNALS-24-02625-JC
Giulio Francesco Romiti, Giovanni Talerico

Source citation: Lopes RD, Granger CB, Wojdyla DM, et al. Apixaban vs aspirin according to CHA2DS2-VASc score in subclinical atrial fibrillation: insights from ARTESiA. J Am Coll Cardiol. 2024;84:354-364. 39019530.

来源引用:Lopes RD、Granger CB、Wojdyla DM 等:亚临床心房颤动患者根据 CHA2DS2-VASc 评分选择阿哌沙班与阿司匹林:来自 ARTESiA 的启示。J Am Coll Cardiol.2024;84:354-364.39019530.
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引用次数: 0
In active ulcerative colitis, risankizumab induced and maintained remission. 在活动性溃疡性结肠炎中,利桑珠单抗可诱导并维持病情缓解。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.7326/ANNALS-24-02768-JC
Alessandro Pedicelli, Waqqas Afif

Source citation: Louis E, Schreiber S, Panaccione R, et al; INSPIRE and COMMAND Study Group. Risankizumab for ulcerative colitis: two randomized clinical trials. JAMA. 2024;332:881-897. 39037800.

来源引用:Louis E, Schreiber S, Panaccione R, et al; INSPIRE 和 COMMAND 研究小组。利桑珠单抗治疗溃疡性结肠炎:两项随机临床试验。美国医学会杂志》。2024;332:881-897.39037800.
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引用次数: 0
Forgiveness. 宽恕。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.7326/ANNALS-24-01400
Ami L DeWaters
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引用次数: 0
Seersucker Uniform, Birmingham VA, 1979 : A Seussian Sonnet in a Variation on the American Sentence. Seersucker Uniform,弗吉尼亚州伯明翰,1979 年:美式句式变体的苏俄十四行诗。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.7326/M23-1834
Maryella Desak Sirmon
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引用次数: 0
Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial. 成人代谢综合征患者的限时进食:随机对照试验。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI: 10.7326/M24-0859
Emily N C Manoogian, Michael J Wilkinson, Monica O'Neal, Kyla Laing, Justina Nguyen, David Van, Ashley Rosander, Aryana Pazargadi, Nikko R Gutierrez, Jason G Fleischer, Shahrokh Golshan, Satchidananda Panda, Pam R Taub

Background: Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.

Objective: To determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.

Design: Randomized controlled trial. (ClinicalTrials.gov: NCT04057339).

Setting: Clinical research institute.

Participants: Adults with metabolic syndrome including elevated fasting glucose or hemoglobin A1c (HbA1c; pharmacotherapy allowed).

Intervention: Participants were randomly assigned to standard-of-care (SOC) nutritional counseling alone (SOC group) or combined with a personalized 8- to 10-hour TRE intervention (≥4-hour reduction in eating window) (TRE group) for 3 months. Timing of dietary intake was tracked in real time using the myCircadianClock smartphone application.

Measurements: Primary outcomes were HbA1c, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and glycemic assessments from continuous glucose monitors.

Results: 108 participants from the TIMET study completed the intervention (89% of those randomly assigned; 56 women, mean baseline age, 59 years; body mass index of 31.22 kg/m2; eating window of 14.19 hours). Compared with SOC, TRE improved HbA1c by -0.10% (95% CI, -0.19% to -0.003%). Statistical outcomes were adjusted for age. There were no major adverse events.

Limitation: Short duration, self-reported diet, potential for multiple elements affecting outcomes.

Conclusion: Personalized 8- to 10-hour TRE is an effective practical lifestyle intervention that modestly improves glycemic regulation and may have broader benefits for cardiometabolic health in adults with metabolic syndrome on top of SOC pharmacotherapy and nutritional counseling.

Primary funding source: National Institutes of Health.

背景:限时进食(TRE)是指在不强制减少卡路里的情况下,将每日饮食摄入量限制在8至10小时内,这可能会对心脏代谢产生益处:目的:确定限时进食作为一种生活方式干预措施,结合目前的标准治疗方法,对患有代谢综合征的成年人的心脏代谢健康有何影响:设计:随机对照试验。(设计:随机对照试验(ClinicalTrials.gov:NCT04057339):临床研究机构:成人代谢综合征患者,包括空腹血糖或血红蛋白 A1c(HbA1c;允许药物治疗)升高:参与者被随机分配到单独的标准护理(SOC)营养咨询(SOC 组)或结合个性化的 8-10 小时 TRE 干预(进食时间≥4 小时)(TRE 组),为期 3 个月。使用 myCircadianClock 智能手机应用程序实时跟踪饮食摄入时间:主要结果为 HbA1c、空腹血糖、空腹胰岛素、胰岛素抵抗平衡模型评估以及连续血糖监测仪的血糖评估:108 名 TIMET 研究参与者完成了干预(占随机分配人数的 89%;56 名女性,平均基线年龄为 59 岁;体重指数为 31.22 kg/m2;进食时间为 14.19 小时)。与 SOC 相比,TRE 将 HbA1c 改善了-0.10%(95% CI,-0.19% 至-0.003%)。统计结果根据年龄进行了调整。无重大不良反应:局限性:持续时间短,自我报告饮食,可能有多种因素影响结果:个性化 8 至 10 小时 TRE 是一种有效的实用生活方式干预措施,可适度改善血糖调节,并在 SOC 药物治疗和营养咨询的基础上,对患有代谢综合征的成年人的心脏代谢健康产生更广泛的益处:主要资金来源:美国国立卫生研究院。
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引用次数: 0
Web Exclusive. Annals Graphic Medicine - Second Year Medical School - Do As I Say, Not As I Do. 网络独家。Annals Graphic Medicine - 医学院二年级 - Do As I Say, Not As I Do.
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-10-22 DOI: 10.7326/G23-0053
Merlin Kochunilathil
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引用次数: 0
In older adults receiving high-risk medications, a deprescribing intervention did not reduce falls at 18 mo. 在接受高风险药物治疗的老年人中,取消处方的干预措施并没有减少他们在 18 个月后跌倒的情况。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-11-05 DOI: 10.7326/ANNALS-24-02770-JC
Jacob A Lebin, Elizabeth Goldberg

Source citation: Phelan EA, Williamson BD, Balderson BH, et al. Reducing central nervous system-active medications to prevent falls and injuries among older adults: a cluster randomized clinical trial. JAMA Netw Open. 2024;7:e2424234. 39052289.

来源引用:Phelan EA, Williamson BD, Balderson BH, et al. 减少中枢神经系统活性药物以预防老年人跌倒和受伤:分组随机临床试验。JAMA Netw Open.2024;7:e2424234.39052289.
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引用次数: 0
Vitamin D Deficiency Increases Mortality Risk in the UK Biobank. 英国生物库中的维生素 D 缺乏会增加死亡风险。
IF 19.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-29 DOI: 10.7326/ANNALS-24-02796
Elina Hyppönen, Joshua P Sutherland, Ang Zhou
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引用次数: 0
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