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In hypertension with high CV risk, intensive vs. standard BP-lowering therapy improved HRQoL by a small amount at a median 3.4 y. 在高危高血压患者中，强化降压治疗与标准降压治疗相比，HRQoL的改善幅度较小，中位值为3.4 y。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-25-05477-JC
Sean P Haley

Clinical impact ratings: GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].

临床影响评分：GIM/FP/GP:[公式：见文]心脏病学：[公式：见文]。
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引用次数: 0
In patients with CAD, clopidogrel vs. aspirin monotherapy reduces MACCE without increasing major bleeding. 在冠心病患者中，氯吡格雷与阿司匹林单药治疗可减少MACCE而不增加大出血。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-25-05630-JC
Michelle D Kelsey

Clinical impact ratings: GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].

临床影响评分：GIM/FP/GP:[公式：见文]心脏病学：[公式：见文]。
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引用次数: 0
Annals On Call - The Role of Corticosteroids in Severe Pneumonia. 随叫随到——皮质类固醇在重症肺炎中的作用。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-26-00380-OC
Robert M Centor, Michael Klompas
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引用次数: 0
Annals Video Summary - Care of Bereaved Persons: A Systematic Review. 录像摘要-照顾失去亲人的人：一个系统的回顾。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-25-05387-VS
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引用次数: 0
In moderate to severe chronic breathlessness, low-dose, long-acting oral morphine did not improve worst breathlessness at 28 d. 在中度至重度慢性呼吸困难中，低剂量长效口服吗啡在28 d时没有改善最严重的呼吸困难。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-25-05315-JC
Guy W Soo Hoo

Clinical impact ratings: GIM/FP/GP: [Formula: see text] Pulmonology: [Formula: see text].

临床影响评分：GIM/FP/GP:[公式：见文]肺科学：[公式：见文]。
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引用次数: 0
Care of Bereaved Persons : A Systematic Review. 照顾丧亲之人：系统回顾。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-24-03679
Sangeeta Ahluwalia, Julia Bandini, Margaret Maglione, Jeremy Miles, Kelsey O'Hollaren, Diana Zhang, Manasi Yedavalli, Sachi Yagyu, Aneesa Motala, Susanne Hempel

Background: Bereavement after the death of someone close is universal, and clinicians may be uncertain if or what interventions may be beneficial.

Purpose: To synthesize effects of health care interventions for bereaved children and adults.

Data sources: Eight databases were searched from inception in September 2025, supplemented with screening reviews, guidelines, federal register entries, and expert input.

Study selection: Dual independent reviewers selected randomized controlled trials (RCTs) comparing interventions for bereaved or soon-to-be bereaved persons with usual care, no intervention, or an alternative intervention.

Data extraction: Outcomes were evaluated using the abstractor-checker model. Risk of bias was assessed; random-effects meta-analysis was used for effect estimates; multiple effect modifiers were explored; and applicability, generalizability, and strength of evidence (SoE) were determined.

Data synthesis: A total of 169 RCTs reported in 303 publications evaluated psychotherapy; expert-facilitated support groups; pharmacotherapy; peer support; self-help interventions; writing, music, and art therapy; enhanced provider contact; and integrative medicine for bereaved persons. Risk of bias was substantial, and only 15 RCTs included children. There was moderate SoE that individual psychotherapy improves grief disorder, grief, and depression symptoms and low SoE that expert-facilitated support groups and enhanced contact with health care providers may improve depression symptoms. Other interventions showed conflicting results, indicated no benefit, or had insufficient SoE.

Limitations: Research focused on grief in adults, study populations were complex, and the review may have missed culturally specific interventions.

Conclusion: Psychotherapy can improve key outcomes in bereaved adults, and expert-facilitated support groups and enhanced provider contact may also provide benefits. Evidence for other bereavement interventions, approaches for children, and outcomes beyond general grief or grieving, grief disorder, and depression symptoms is limited.

Primary funding source: Agency for Healthcare Research and Quality. (PROSPERO: CRD42023466057).

背景：亲人去世后的丧亲之痛是普遍的，临床医生可能不确定是否或哪些干预措施可能有益。目的：综合分析儿童和成人丧亲者保健干预措施的效果。数据来源：自2025年9月成立以来检索了8个数据库，并补充了筛选审查、指南、联邦登记册条目和专家意见。研究选择：双独立审稿人选择随机对照试验（rct），比较对丧亲者或即将丧亲者的干预与常规护理、不干预或替代干预。数据提取：使用抽象者-检查者模型评估结果。评估偏倚风险；随机效应荟萃分析用于效果估计；探索多种效果调节剂；并确定适用性、概括性和证据强度（SoE）。数据综合：303份评估心理治疗的出版物共报告了169项随机对照试验；专家协助的支助小组；药物治疗;同伴支持;自助干预;写作、音乐和艺术治疗；加强与供应商的联系；以及为丧亲者提供的中西医结合。偏倚风险很大，只有15项随机对照试验纳入了儿童。中等程度的人认为个体心理治疗可以改善悲伤障碍、悲伤和抑郁症状，低程度的人认为专家促进的支持团体和加强与卫生保健提供者的联系可以改善抑郁症状。其他干预显示出相互矛盾的结果，表明没有益处，或SoE不足。局限性：研究集中于成年人的悲伤，研究人群很复杂，并且回顾可能错过了文化特定的干预措施。结论：心理治疗可以改善丧亲成人的主要结局，专家促进的支持小组和加强的提供者联系也可能提供益处。关于其他丧亲干预措施、儿童治疗方法以及一般悲伤或悲伤、悲伤障碍和抑郁症状之外的结果的证据有限。主要资金来源：医疗保健研究和质量局。(普洛斯彼罗:CRD42023466057)。
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引用次数: 0
Small Acts of Compassion: What Current Evidence Does Not Measure. 微小的同情之举：当前证据无法衡量的。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-25-05352
Joanne Cacciatore, Joyal Mulheron
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引用次数: 0
In severe chronic rhinosinusitis with polyps and asthma, dupilumab improved nasal polyp score and sense of smell vs. omalizumab at 24 wk. 在伴有息肉和哮喘的严重慢性鼻窦炎患者中，dupilumab与omalizumab相比，在24周时改善了鼻息肉评分和嗅觉。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-25-05457-JC
Derek K Chu, Matthew A Rank

Clinical impact ratings: GIM/FP/GP: [Formula: see text] Allerg & Immunol: [Formula: see text] Pulmonology: [Formula: see text].

临床影响评分：GIM/FP/GP:[公式：见文]过敏与免疫：[公式：见文]肺科：[公式：见文]。
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引用次数: 0
In patients with ischemic stroke, NVAF, and ASCVD, adding an antiplatelet to OAC therapy did not affect net clinical benefit at 2 y. 在缺血性卒中、非瓣瓣性房颤和ASCVD患者中，在OAC治疗中加入抗血小板并不影响2年时的净临床获益。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-25-05308-JC
Mukul Sharma, Abhilekh Srivastava

Clinical impact ratings: GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text] Hematology: [Formula: see text].

临床影响评分：GIM/FP/GP:[公式：见文]神经病学：[公式：见文]血液学：[公式：见文]。
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引用次数: 0
Adapting Cervical Cancer Screening in Vaccinated Populations: Individualized Versus Population-Based Approaches. 适应宫颈癌筛查接种人群：个体化与基于人群的方法。
IF 15.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Annals of Internal Medicine
Pub Date : 2026-02-03 DOI: 10.7326/ANNALS-25-05559
Nicolas Wentzensen, Didem Egemen
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引用次数: 0
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