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Journal of transplant coordination : official publication of the North American Transplant Coordinators Organization (NATCO)最新文献

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Estimating the non-heart-beating donor potential at a trauma center. 估计创伤中心非心脏供体的潜力。
K A Evers, D D Lewis

The number of people awaiting a life-saving transplant far outweighs the number of organs available for transplantation. Our organ procurement organization sought to identify the non-heart-beating donor potential at a large urban level 1 trauma center. We modified the death-record reviews for a 2-year period and determined that a total of 23 patients who expired were suitable for non-heart-beating donation. Therefore, it can be hypothesized that if all large urban level 1 trauma centers participated in non-heart-beating donation, more organs would be available for transplantation.

等待挽救生命的移植手术的人数远远超过可供移植的器官数量。我们的器官采购组织试图在一个大型城市一级创伤中心寻找潜在的非心脏供体。我们修改了2年期间的死亡记录回顾,并确定共有23名死亡患者适合进行非心脏跳动捐赠。因此,可以假设,如果所有大型城市一级创伤中心都参与非心脏跳动捐赠,将有更多的器官可供移植。
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引用次数: 7
Outpatient Housing following Kidney Transplantation 肾移植后门诊住房
K. Scholz, K. L. Turrisi
Journal of Transplant Coordination, Vol. 9, Number 3, September 1999 The desire to reduce the costs of this transplant center’s organ transplant programs prompted a review of major factors influencing expenditures in 1995. Each transplant program, including bone marrow, heart, kidney, liver, lung, and pancreas, was evaluated. Outcomes, costs (mean and median), and LOS were benchmarked with other university hospitals, with the use of University Health System Consortium (UHC) data and Medicare data where applicable. The clinical outcomes of all organ transplant programs at this center met or exceeded national averages.1 Based on the use of UHC data, the costs of providing care were consistently below other university programs reporting data in the survey in all programs except bone marrow transplantation. Each program’s LOS was compared to data received from communication with other transplant centers. Although most of the center’s organ transplant programs compared favorably with other centers in the UHC, the reported LOS at this center for both kidney and bone marrow transplant patients was highly variable and often longer than at other centers.
为了减少该移植中心器官移植项目的费用,1995年对影响支出的主要因素进行了审查。每个移植项目,包括骨髓、心脏、肾脏、肝脏、肺和胰腺,都进行了评估。结果、成本(平均和中位数)和LOS与其他大学医院进行基准比较,使用大学卫生系统联盟(UHC)数据和医疗保险数据(如适用)。该中心所有器官移植项目的临床结果均达到或超过全国平均水平根据使用的全民健康覆盖数据,除骨髓移植外,所有项目提供护理的成本始终低于调查中报告数据的其他大学项目。每个项目的LOS与从其他移植中心收到的通信数据进行了比较。虽然该中心的大多数器官移植项目与UHC的其他中心相比都是有利的,但该中心报告的肾和骨髓移植患者的LOS变化很大,通常比其他中心更长。
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引用次数: 1
Issues in Cyclosporine Drug Substitution: Implications for Patient Management 环孢素药物替代的问题:对患者管理的影响
M. Bartucci
Journal of Transplant Coordination, Vol. 9, Number 3, September 1999 survival rates have also improved in the past decade. Between 1986 and 1993, median cadaveric graft survival increased from 5.4 years to 8.5 years, whereas median live donor graft survival increased from 9.7 years to 14.7 years.3 Excluding death with a functioning graft, chronic rejection accounts for the majority of late graft losses.4 Risk factors for chronic rejection include history of acute rejection, inadequate immunosuppression, delayed graft function, acute tubular necrosis, donor organ characteristics (eg, age >60 years and cadaveric vs live donor), recipient characteristics (eg, gender and age), pretransplantation diseases (eg, diabetes and hypertension), and infection.5 Clinical management of the transplant recipient should therefore include strategies to prevent the development of chronic rejection, thereby improving long-term graft survival. As more options for immunotherapy become available, transplant recipients will continue to experience better short-term and long-term outcomes. The list of available immmunosuppressants continues to expand (Table 1) and several other promising new agents are under investigation. Although new combinations are being tested, the current optimal immunosuppressive regimen remains predominantly calcineurin-inhibitor based. Issues in cyclosporine drug substitution: implications for patient management
移植协调杂志,第9卷,第3期,1999年9月存活率在过去十年中也有所提高。从1986年到1993年,尸体移植的中位生存期从5.4年增加到8.5年,而活体移植的中位生存期从9.7年增加到14.7年排除移植物功能正常导致的死亡,慢性排斥反应是晚期移植物损失的主要原因慢性排斥反应的危险因素包括急性排斥反应史、免疫抑制不足、移植物功能延迟、急性肾小管坏死、供体器官特征(如年龄0 ~ 60岁、尸体供体与活体供体)、受体特征(如性别和年龄)、移植前疾病(如糖尿病和高血压)和感染因此,移植受者的临床管理应包括预防慢性排斥反应发展的策略,从而提高移植的长期存活率。随着免疫疗法的选择越来越多,移植受者将继续体验到更好的短期和长期结果。可用的免疫抑制剂名单继续扩大(表1),其他一些有前途的新药正在研究中。虽然新的组合正在测试中,目前最佳的免疫抑制方案仍然主要是钙调磷酸酶抑制剂为主。环孢素药物替代的问题:对患者管理的影响
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引用次数: 0
Liver donation by a trauma patient: a case study in placement. 创伤患者肝脏捐献:安置的个案研究。
M Kraljevich

Currently, more than 64,000 people are awaiting transplants in the United States. Transplant coordinators must do everything possible to ensure that viable organs from consented donors are transplanted. To evaluate donors and organ function, transplant coordinators rely on a multitude of diagnostic tests to determine donor organ suitability. How reliable are the results of these tests? The following case study presents an incident in which diagnostic test results were not accurate; as a result, transplant centers deferred what turned out to be a normal, atraumatic organ. The end result was that this organ was placed, but only after actual visualization in the operating room and the granting of full waivers to the transplanting center.

目前,美国有超过6.4万人在等待器官移植。移植协调员必须尽一切可能确保来自经同意的捐赠者的可存活器官得到移植。为了评估供体和器官功能,移植协调员依靠大量的诊断测试来确定供体器官的适用性。这些测试的结果有多可靠?下面的案例研究提出了一个事件,其中诊断测试结果不准确;因此,移植中心推迟了原本正常的、无创伤的器官移植。最终的结果是,这个器官被放置了,但只有在手术室实际可视化并给予移植中心完全豁免之后。
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引用次数: 2
Nerve Transplantation: A Father's Final Gift 神经移植:父亲的最后礼物
T. Fabián, K. Lohmann
Offering the option of organ and tissue donation to grieving families may seem stressful, but asking the question may provide a positive means to extend care to the bereaved family and help others in return. Many donor families have said donation was an opportunity to make some sense out of a senseless situation and to relieve some of the grief they experienced. This article presents a case that started with such a discussion by ICU nurses in one of our donor hospitals, and ended with successful organ and tissue recovery and transplantation. As “routine” as this may sound, it was anything but routine—it made history.
向悲伤的家庭提供器官和组织捐赠的选择可能看起来很有压力,但提出这个问题可能会提供一种积极的方式来照顾失去亲人的家庭,并帮助其他人作为回报。许多捐赠家庭表示,捐赠是一个机会,让他们在毫无意义的情况下找到一些意义,减轻他们所经历的一些悲伤。本文介绍了一个病例,在我们的一家供体医院的ICU护士开始这样的讨论,并以成功的器官和组织恢复和移植结束。尽管这听起来像是“例行公事”,但它绝不是例行公事——它创造了历史。
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引用次数: 0
Utilization of donated lungs in Australia: 1989-1997. 澳大利亚捐献肺的利用:1989-1997。
G T Armstrong

Lung and heart-lung transplantation was first undertaken in Australia in the late 1980s and early 1990s. Although detailed data are available on Australian lung transplantation outcomes, little data are available regarding the utilization of donated lungs. This study examines donated lung utilization rates and considers various factors that may affect these rates. Australian donation and transplantation data were analyzed for the years 1989 through 1997. Results showed that 24% of overall donors were lung donors. The percentage of donors from whom at least 1 lung was transplanted increased from 6% in 1989 to 36% in 1997. Heart-lung transplantation rates changed little (2%-9%), whereas bilateral lung transplantation increased from 1% to 23% of donors. Single-lung donors accounted for 32% of lung donors in 1997. Uniform basic donor criteria and management guidelines, simple allocation mechanisms, and cooperative retrieval have evolved during this time. Close collaboration at the time of donation between units, coordinators, and ICUs has allowed early retrieval from well-managed donors.

肺和心肺移植最早于20世纪80年代末和90年代初在澳大利亚进行。虽然有关于澳大利亚肺移植结果的详细数据,但很少有关于捐赠肺的利用的数据。本研究考察了捐赠肺的利用率,并考虑了可能影响这些利用率的各种因素。澳大利亚的捐赠和移植数据分析了1989年至1997年。结果显示24%的供体是肺供体。至少有一个肺被移植的供体比例从1989年的6%上升到1997年的36%。心肺移植的比例变化不大(2%-9%),而双侧肺移植的比例从1%增加到23%。1997年,单肺供体占肺供体的32%。在此期间,统一的基本捐赠标准和管理准则、简单的分配机制和合作检索已经形成。各单位、协调员和icu之间在捐赠时的密切合作,使其能够及早从管理良好的捐赠者处回收。
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引用次数: 1
Outpatient housing following kidney transplantation. 肾移植后的门诊住房。
K A Scholz, K L Turrisi

The purpose of this article is to describe the efforts of a medium-sized kidney transplant program in the southeastern United States to reduce the inpatient length of stay by moving toward the outpatient arena, thereby reducing the overall cost of the transplant experience. An outpatient transplant unit was created to house patients who were medically stable but still required further monitoring and education prior to being discharged. The development and implementation of the transplant outpatient unit significantly reduced inpatient length of stay following kidney transplantation from 14 to 5 days. The benefits and outcomes of the transplant outpatient unit were impressive.

本文的目的是描述美国东南部一个中型肾脏移植项目的努力,通过向门诊领域转移来减少住院病人的住院时间,从而降低移植经验的总体成本。设立了一个门诊移植单位,收容医学上稳定但在出院前仍需要进一步监测和教育的病人。移植门诊单元的发展和实施显著减少了肾移植后的住院时间,从14天减少到5天。移植门诊的益处和结果令人印象深刻。
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引用次数: 1
Family Communication Coordination: A Program to Increase Organ Donation 家庭沟通协调:增加器官捐献的计划
A. Linyear, A. Tartaglia
Journal of Transplant Coordination, Vol. 9, Number 3, September 1999 nically and racially diverse population. During l996 and l997, MCVH recovered organs from 36 donors, and 249 individuals received at least 1 solid organ. In l996, MCVH, in an effort to improve its performance, became a part of the collaborative project to increase organ donation by the University Health System Consortium and the Partnership for Organ Donation (Partnership). The Partnership is an independent nonprofit organization committed to improving organ donation through research and program implementation. The purpose of this article is to present findings following implementation of a systematic hospital-based program to improve organ donation.
移植协调杂志,第9卷,第3期,1999年9月。在1996年和1997年期间,MCVH从36名捐赠者那里恢复了器官,249人接受了至少一个实体器官。1996年,MCVH为了提高其绩效,成为大学卫生系统联盟和器官捐赠伙伴关系(伙伴关系)合作项目的一部分,以增加器官捐赠。该伙伴关系是一个独立的非营利组织,致力于通过研究和项目实施来改善器官捐赠。这篇文章的目的是介绍一个系统的医院为基础的计划,以提高器官捐赠的实施结果。
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引用次数: 0
Utilization of Donated Lungs in Australia: 1989–1997 澳大利亚捐献肺的利用:1989-1997
G. T. Armstrong
Journal of Transplant Coordination, Vol. 9, Number 3, September 1999 ber of studies have been done to determine either the potential for donation or overall donation and transplantation rates. Roels and De Meester1 showed higher rates of thoracic transplantation in the Eurotransplant (the exchange organization that coordinates organ procurement, allocation, and exchange in and between Austria, Belgium, Luxembourg, Germany, and the Netherlands) countries with presumed consent than those with explicit consent legislation. Data are reported in this study as donors and donated lungs per million population per year. A calculation based on their reported populations shows a rate of 25 available lungs per 100 donors for the presumed consent countries compared with a rate of 13 per 100 donors for the nonpresumed consent Eurotransplant countries. The investigators concluded that presumed consent legislation accounted for this discrepancy. A similar calculation based on population applied to a study by Colpitts and Freitag2 shows an overall lung utilization rate of 15 lung transplants per 100 donors in Canada for the same years as reported by Roels and De Meester1 (1992-1994). The United Network for Organ Sharing (UNOS)3 and United Kingdom Transplant Support Service Authority (UKTSSA)4 data for these years show rates of 13 to 15 and 14 to 18 lung transplants per 100 donors, Utilization of donated lungs in Australia: 1989-1997
移植协调杂志,第9卷,第3期,1999年9月,许多研究已经完成,以确定捐赠的潜力或总体捐赠和移植率。Roels和De Meester1显示,在欧洲移植(协调奥地利、比利时、卢森堡、德国和荷兰之间的器官采购、分配和交换的交换组织)国家中,假定同意的胸部移植率高于明确同意立法的国家。本研究报告的数据为每年每百万人的供体和捐赠肺。根据他们报告的人口进行计算,在假定同意的国家中,每100名捐献者中有25个可用肺,而在非假定同意的欧洲移植国家中,每100名捐献者中有13个可用肺。调查人员得出结论,推定同意立法解释了这种差异。Colpitts和Freitag2在一项研究中采用了类似的基于人口的计算方法2,结果显示,与Roels和De Meester1(1992-1994)报告的同期,加拿大每100名供体中有15例肺移植的总体肺利用率。联合器官共享网络(UNOS)和英国移植支持服务管理局(UKTSSA)这些年的数据显示,每100名捐赠者的肺移植率分别为13至15例和14至18例
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引用次数: 0
Quality of life after transplantation. 移植后的生活质量。
L Ohler
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引用次数: 4
期刊
Journal of transplant coordination : official publication of the North American Transplant Coordinators Organization (NATCO)
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