Objective: To investigate the clinical characteristics of acute frontal sinusitis accompanied with extra-dural abscess.
Method: A case of acute frontal sinusitis accompanied with extra-dural abscess diagnosed by CT was analyzed, and the relative literatures were reviewed.
Result: Headache, high fever and failure to antibiotic therapy were the main three clinical characteristics.
Conclusion: It is the most important thing to drainage the abscess except for antibiotic therapy for acute frontal sinusitis accompanied with extra-dural abscess. Antibiotic therapy cannot substitute for surgery.
Objective: Adenoidal hypertrophy in children is associated with obstructive manifestations like mouth breathing, snoring, night cough. However, the sleep architecture is poorly defined in children with AH, which is this studies for.
Method: A computer-assistant diagnostic system was used for polysomnography (PSG) recording. Sleep was scored manually according to the standard set by Rechtschaffen. 47 children with adenotonsillar hypertrophy (AH) were defined by PSG and compared with normal children PSG results.
Result: (1) Compared with normal children, AH group had increased stage I: (15. 4 +/- 9.3)% vs (7.9 +/- 6.8)% (P < 0.01) and decreased stage II: (41.8 +/- 9.7)% vs (46.7 +/- 7.6)% (P < 0.01); increased Delta (26.2 +/- 10.6)% vs (23.3 +/- 8.7) % (P > 0.05); obviously decreased in REM: (7.7 +/- 4.9)% vs (27.3 +/- 5.6)% (P < 0.01); NREM (83.33%) was increasingly; (2) AH group had increased Arousal Index(ARI) 32.8 +/- 26.03 vs 18.3 +/- 12.2 (P < 0.05); (3) The latent period of REM was (157.1 +/- 71.4) min and about two times long as normal children.
Conclusion: Sleep architecture is abnormal in children with AH. Frequent electroencephalogram arousals from sleep may result in significant sleep fragmentation,but the deep sleep is sufficient. Further studies are needed to determine whether abnormalities in sleep architecture contribute to quality of life.
Objective: To investigate the protective effects of minocycline against apoptosis of olfactory sensory neurons induced by sinusitis.
Method: Sixty adult SD rats were divided randomly into three groups: control group (group A), sinusitis group (group B) and intravenous injection of minocycline group (group C). The rats were sacrificed at 1,3,5 d and 7 d after surgery, and then the tissue sections of olfactory epithelium were stained and evaluated with hematoxylin and eosin (HE) and immunohistochemistry method.
Result: The histopathological changes in maxillary sinus epithelium tissues observed with he staining microscopic examination in group B and C were worse than that in group A. Significant difference of the thickness of olfactory epithelium and Caspase-3 activity was demonstrated in group B and group C.
Conclusion: The result demonstrated that minocycline could inhibit expression of Caspase-3 in rats with sinusitis.