Annals of Biomedical Engineering最新文献_第4页

Utilizing Rhythmic Haptic Cueing in Arm Swing Training to Improve Gait Speed Among Older Adults. 利用有节奏的触觉提示在手臂摆动训练中提高老年人的步态速度。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-27 DOI: 10.1007/s10439-024-03669-9

Ines Khiyara, Ben Sidaway, Babak Hejrati

Purpose: Current gait rehabilitation protocols for older adults typically attempt to effect changes in leg movements, while the role of arm movements is often ignored despite evidence of the neurological coupling of the upper and lower extremities. In the present work, we examine the effectiveness of a novel wearable haptic cueing system that targets arm swing to improve various gait parameters in older adults.

Methods: Twenty participants ( $M = 73.4 \pm 6.2$ years) were recruited to analyze their gait during normal and fast walking without haptic cueing. Vibrotactors attached to the arms were then used to give haptic cues that were designed to either increase or decrease arm swing cycle time. The effects of such cueing on gait symmetry and spatiotemporal parameters were then analyzed.

Results: The presentation of the haptic cues significantly altered arm swing cycle time resulting in an increase in gait speed of 18.2% when arm cycle time was decreased and a 12.3% decrease in gait speed when arm cycle time was lengthened. The response to haptic cues was immediate, emphasizing the tight coupling of the arm and legs in the production of gait. Spatiotemporal analysis revealed improvements in gait parameters and symmetry metrics, indicating enhanced coordination between limbs when using tactile cues. Subjective evaluations further supported the system's potential for gait training.

Conclusion: The results reveal the significant potential of the haptic cueing system to modulate gait through arm swing manipulation, leveraging interlimb neural coupling. This aligns with the growing need for home-based gait training solutions, particularly for the older population, and presents a novel approach that could be integrated into current gait rehabilitation practices.

目的：目前老年人的步态康复方案通常试图影响腿部运动的变化，而手臂运动的作用往往被忽视，尽管有证据表明上肢和下肢的神经耦合。在目前的工作中，我们研究了一种新型可穿戴触觉提示系统的有效性，该系统以手臂摆动为目标，改善老年人的各种步态参数。方法：选取20名受试者（M = 73.4±6.2岁），在无触觉提示的情况下进行正常步行和快速步行的步态分析。接在手臂上的振动感受器用来提供触觉提示，以增加或减少手臂摆动周期时间。分析了这些信号对步态对称性和时空参数的影响。结果：触觉提示的出现显著改变了手臂摆动周期时间，导致手臂摆动周期时间缩短时步态速度增加18.2%，手臂摆动周期时间延长时步态速度下降12.3%。对触觉线索的反应是即时的，强调了手臂和腿在步态产生中的紧密耦合。时空分析显示步态参数和对称性指标有所改善，表明使用触觉提示时四肢之间的协调性增强。主观评价进一步支持了该系统在步态训练方面的潜力。结论：触觉线索系统利用肢间神经耦合，通过操纵手臂摆动调节步态具有重要的潜力。这与家庭步态训练解决方案日益增长的需求相一致，特别是对于老年人，并提出了一种可以整合到当前步态康复实践中的新方法。

{"title":"Utilizing Rhythmic Haptic Cueing in Arm Swing Training to Improve Gait Speed Among Older Adults.","authors":"Ines Khiyara, Ben Sidaway, Babak Hejrati","doi":"10.1007/s10439-024-03669-9","DOIUrl":"https://doi.org/10.1007/s10439-024-03669-9","url":null,"abstract":"<p><strong>Purpose: </strong>Current gait rehabilitation protocols for older adults typically attempt to effect changes in leg movements, while the role of arm movements is often ignored despite evidence of the neurological coupling of the upper and lower extremities. In the present work, we examine the effectiveness of a novel wearable haptic cueing system that targets arm swing to improve various gait parameters in older adults.</p><p><strong>Methods: </strong>Twenty participants ( <math><mrow><mi>M</mi> <mo>=</mo> <mn>73.4</mn> <mo>±</mo> <mn>6.2</mn></mrow> </math> years) were recruited to analyze their gait during normal and fast walking without haptic cueing. Vibrotactors attached to the arms were then used to give haptic cues that were designed to either increase or decrease arm swing cycle time. The effects of such cueing on gait symmetry and spatiotemporal parameters were then analyzed.</p><p><strong>Results: </strong>The presentation of the haptic cues significantly altered arm swing cycle time resulting in an increase in gait speed of 18.2% when arm cycle time was decreased and a 12.3% decrease in gait speed when arm cycle time was lengthened. The response to haptic cues was immediate, emphasizing the tight coupling of the arm and legs in the production of gait. Spatiotemporal analysis revealed improvements in gait parameters and symmetry metrics, indicating enhanced coordination between limbs when using tactile cues. Subjective evaluations further supported the system's potential for gait training.</p><p><strong>Conclusion: </strong>The results reveal the significant potential of the haptic cueing system to modulate gait through arm swing manipulation, leveraging interlimb neural coupling. This aligns with the growing need for home-based gait training solutions, particularly for the older population, and presents a novel approach that could be integrated into current gait rehabilitation practices.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental Assessment of Traction Force and Associated Fetal Brain Deformation in Vacuum-Assisted Delivery. 真空辅助分娩中牵引力及相关胎儿脑变形的实验评估。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-22 DOI: 10.1007/s10439-024-03665-z

Estelle Pitti, Lotta Herling, Xiaogai Li, Gunilla Ajne, Matilda Larsson

Vacuum-assisted delivery (VAD) uses a vacuum cup on the fetal scalp to apply traction during uterine contractions, assisting complicated vaginal deliveries. Despite its widespread use, VAD presents a higher risk of neonatal morbidity compared to natural vaginal delivery and biomechanical evidence for safe VAD traction forces is still limited. The aim of this study is to develop and assess the feasibility of an experimental VAD testing setup, and investigate the impact of traction forces on fetal brain deformation. A patient-specific fetal head phantom was developed and subjected to experimental VAD in two testing setups: one with manual and one with automatic force application. The skull phantom was 3D printed using multi-material Polyjet technology. The brain phantom was cast in a 3D-printed mold using a composite hydrogel, and sonomicrometry crystals were used to estimate the brain deformation in three brain regions. The experimental VADs on the fetal head phantom allowed for quantifying brain strain with traction forces up to 112 N. Consistent brain crystal movements aligned with the traction force demonstrated the feasibility of the setup. The estimated brain deformations reached up to 4% and correlated significantly with traction force (p < 0.05) in regions close to the suction cup. Despite limitations such as the absence of scalp modeling and a simplified strain computation, this study provides a baseline for numerical studies and supports further research to optimize the safety of VAD procedures and develop VAD training platforms.

真空辅助分娩（VAD）利用胎儿头皮上的真空杯在子宫收缩时施加牵引力，帮助复杂的阴道分娩。尽管VAD被广泛使用，但与自然阴道分娩相比，VAD呈现出更高的新生儿发病率风险，而且安全VAD牵引力的生物力学证据仍然有限。本研究的目的是开发和评估实验性VAD测试装置的可行性，并探讨牵引力对胎儿脑变形的影响。开发了一种针对患者的胎头假体，并在两种测试设置中进行实验性VAD：一种是手动的，另一种是自动施加力的。颅骨幻影采用多材料Polyjet技术进行3D打印。使用复合水凝胶在3d打印模具中铸造脑幻影，并使用声压测量晶体来估计大脑三个区域的变形。在胎儿头部幻影上的VADs实验可以量化高达112 n的牵引力下的脑应变，大脑晶体运动与牵引力一致，证明了该装置的可行性。估计脑变形高达4%，并与牵引力显著相关(p

{"title":"Experimental Assessment of Traction Force and Associated Fetal Brain Deformation in Vacuum-Assisted Delivery.","authors":"Estelle Pitti, Lotta Herling, Xiaogai Li, Gunilla Ajne, Matilda Larsson","doi":"10.1007/s10439-024-03665-z","DOIUrl":"https://doi.org/10.1007/s10439-024-03665-z","url":null,"abstract":"<p><p>Vacuum-assisted delivery (VAD) uses a vacuum cup on the fetal scalp to apply traction during uterine contractions, assisting complicated vaginal deliveries. Despite its widespread use, VAD presents a higher risk of neonatal morbidity compared to natural vaginal delivery and biomechanical evidence for safe VAD traction forces is still limited. The aim of this study is to develop and assess the feasibility of an experimental VAD testing setup, and investigate the impact of traction forces on fetal brain deformation. A patient-specific fetal head phantom was developed and subjected to experimental VAD in two testing setups: one with manual and one with automatic force application. The skull phantom was 3D printed using multi-material Polyjet technology. The brain phantom was cast in a 3D-printed mold using a composite hydrogel, and sonomicrometry crystals were used to estimate the brain deformation in three brain regions. The experimental VADs on the fetal head phantom allowed for quantifying brain strain with traction forces up to 112 N. Consistent brain crystal movements aligned with the traction force demonstrated the feasibility of the setup. The estimated brain deformations reached up to 4% and correlated significantly with traction force (p < 0.05) in regions close to the suction cup. Despite limitations such as the absence of scalp modeling and a simplified strain computation, this study provides a baseline for numerical studies and supports further research to optimize the safety of VAD procedures and develop VAD training platforms.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing a Structurally Modified Mechanical Lumped Model of the Human Tibia and Shin Guard Using Modal Analysis. 利用模态分析建立人体胫骨和胫护的结构改进机械集总模型。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-22 DOI: 10.1007/s10439-024-03668-w

Ehsan Moghaddam, Aref Afsharfard

Shins are one of the most vulnerable bones in human body. Shin guards are evaluated by their effectiveness in reducing the force applied to the bone. In this study, a structural modified mechanical lumped model of the shin guard was developed to provide maximum force distribution using physical parameter change modification technique and genetic algorithm. Modal analysis and finite element methods were used to determine the dynamic behavior of the system in the frequency range of 0-3000 Hz. In this research, FE results had an encouraging agreement with those in experimental test with a Mean Absolute Error (MAE) found as 34.94. The results proposed two design zones to select the stiffness of the shin guard. The stiffnesses K₁ and K₂ were selected between the values in the design zones. For situation, K₁ = 7.9 × 10⁵ N/m and K₂ = 6.3 × 10⁵ N/m, the distribution parameter was equal to 76% and f₁ = 1.87F, f₂ = 0.71F f₃ = 1.81F, meaning the force was effectively distributed.

胫骨是人体最脆弱的骨骼之一。胫骨护具是评估其有效性，以减少施加在骨头上的力。在本研究中，利用物理参数改变修改技术和遗传算法，建立了一个结构改进的胫骨护套力学集总模型，以提供最大的力分布。采用模态分析和有限元方法确定了系统在0 ~ 3000 Hz频率范围内的动态特性。本研究的有限元结果与实验结果一致，平均绝对误差（MAE）为34.94。结果提出了两个设计区域来选择护胫的刚度。刚度K1和K2在设计区值之间选取。当K1 = 7.9 × 105 N/m, K2 = 6.3 × 105 N/m时，分布参数为76%，f1 = 1.87F, f2 = 0.71F, f3 = 1.81F，说明力得到有效分布。

引用次数: 0

Experimental Measurement and Mathematical Quantification of Fixed-Charged Density in Rat and Pig Brain Tissue. 大鼠和猪脑组织固定电荷密度的实验测量和数学定量。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-19 DOI: 10.1007/s10439-024-03666-y

Delin Zeng, Andrew V Basilio, Leanne A Pichay, Gerard A Ateshian, Olivia S Hansen, Alexander Romanov, Barclay Morrison

Cerebral edema is associated with poor prognosis because brain swelling within the rigid skull raises intracranial pressure, exacerbating secondary injuries following traumatic brain injury. Brain swelling can be characterized by triphasic biomechanics, which models brain tissue as a mixture of a deformable porous solid matrix with a negative fixed-charged density (FCD), water, and monovalent counterions. When brain cells die, the intracellular FCD is exposed, attracting cations into the cells. The increase in intracellular solute concentration generates osmotic pressure via the Gibbs-Donnan effect, driving water into cells and causing swelling. This study quantifies the FCD of rat and pig brain tissue by measuring the pressure generated by tissue within a confined volume as cells died. Rat brain tissue generated an averaged swelling pressure of 52.92 ± 20.40 mmHg (mean ± one standard deviation). Variations were observed between pig cortical white matter (7.14 ± 4.79 mmHg) and cortical gray matter (33.86 ± 11.89 mmHg). The corresponding FCD values were 42.54 ± 8.14 mEq/L for rat brain tissue, and 15.18 ± 5.38 mEq/L and 34.22 ± 6.31 mEq/L for pig cortical white and gray matter, respectively. Treating the rat brain tissue with DNAse, heparinase I, heparinase III, and chondroitinase ABC to degrade FCD significantly reduced swelling pressure. Good agreement between the experimental and numerically simulated responses supported the role of the FCD in cerebral edema formation. The reported FCD values can improve the biofidelity of computational models to predict post-traumatic cerebral edema, aiding the improvement of safety systems.

脑水肿与预后不良有关，因为坚硬颅骨内的脑肿胀会升高颅内压，加剧外伤性脑损伤后的继发性损伤。脑肿胀可以用三相生物力学来表征，它将脑组织建模为具有负固定电荷密度（FCD）的可变形多孔固体基质、水和单价反离子的混合物。当脑细胞死亡时，细胞内的FCD暴露出来，吸引阳离子进入细胞。细胞内溶质浓度的增加通过吉布斯-多南效应产生渗透压，使水进入细胞并引起肿胀。本研究通过测量细胞死亡时组织在有限体积内产生的压力来量化大鼠和猪脑组织的FCD。大鼠脑组织产生的平均肿胀压为52.92±20.40 mmHg（平均值±1标准差）。猪皮质白质（7.14±4.79 mmHg）和皮质灰质（33.86±11.89 mmHg）之间存在差异。大鼠脑组织的FCD值分别为42.54±8.14 mEq/L，猪皮质白质和灰质的FCD值分别为15.18±5.38 mEq/L和34.22±6.31 mEq/L。用DNAse、肝素酶I、肝素酶III和软骨素酶ABC处理大鼠脑组织降解FCD显著降低肿胀压。实验和数值模拟反应之间的良好一致性支持了FCD在脑水肿形成中的作用。报道的FCD值可以提高预测创伤后脑水肿的计算模型的生物保真度，有助于改进安全系统。

{"title":"Experimental Measurement and Mathematical Quantification of Fixed-Charged Density in Rat and Pig Brain Tissue.","authors":"Delin Zeng, Andrew V Basilio, Leanne A Pichay, Gerard A Ateshian, Olivia S Hansen, Alexander Romanov, Barclay Morrison","doi":"10.1007/s10439-024-03666-y","DOIUrl":"https://doi.org/10.1007/s10439-024-03666-y","url":null,"abstract":"<p><p>Cerebral edema is associated with poor prognosis because brain swelling within the rigid skull raises intracranial pressure, exacerbating secondary injuries following traumatic brain injury. Brain swelling can be characterized by triphasic biomechanics, which models brain tissue as a mixture of a deformable porous solid matrix with a negative fixed-charged density (FCD), water, and monovalent counterions. When brain cells die, the intracellular FCD is exposed, attracting cations into the cells. The increase in intracellular solute concentration generates osmotic pressure via the Gibbs-Donnan effect, driving water into cells and causing swelling. This study quantifies the FCD of rat and pig brain tissue by measuring the pressure generated by tissue within a confined volume as cells died. Rat brain tissue generated an averaged swelling pressure of 52.92 ± 20.40 mmHg (mean ± one standard deviation). Variations were observed between pig cortical white matter (7.14 ± 4.79 mmHg) and cortical gray matter (33.86 ± 11.89 mmHg). The corresponding FCD values were 42.54 ± 8.14 mEq/L for rat brain tissue, and 15.18 ± 5.38 mEq/L and 34.22 ± 6.31 mEq/L for pig cortical white and gray matter, respectively. Treating the rat brain tissue with DNAse, heparinase I, heparinase III, and chondroitinase ABC to degrade FCD significantly reduced swelling pressure. Good agreement between the experimental and numerically simulated responses supported the role of the FCD in cerebral edema formation. The reported FCD values can improve the biofidelity of computational models to predict post-traumatic cerebral edema, aiding the improvement of safety systems.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated Microgravity 短期模拟微重力环境下包裹软骨细胞的代谢特征。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-18 DOI: 10.1007/s10439-024-03667-x

Annika R. Bergstrom, Matthew G. Glimm, Eden A. Houske, Gwendolyn Cooper, Ethan Viles, Marrin Chapman, Katherine Bourekis, Hope D. Welhaven, Priyanka P. Brahmachary, Alyssa K. Hahn, Ronald K. June

The mechanism by which chondrocytes respond to reduced mechanical loading environments and the subsequent risk of developing osteoarthritis remains unclear. This is of particular concern for astronauts. In space the reduced joint loading forces during prolonged microgravity (10⁻⁶ g) exposure could lead to osteoarthritis (OA), compromising quality of life post-spaceflight. In this study, we encapsulated human chondrocytes in an agarose gel of similar stiffness to the pericellular matrix to mimic the cartilage microenvironment. We then exposed agarose-chondrocyte constructs to simulated microgravity (SM) for four days using a rotating wall vessel (RWV) bioreactor to better assess the cartilage health risks associated with spaceflight. Metabolites extracted from media and agarose gel constructs were analyzed on liquid chromatography-mass spectrometry. Global metabolomic profiling detected a total of 1205 metabolite features, with 497 significant metabolite features identified by ANOVA (FDR-corrected p-value < 0.05). Specific metabolic shifts detected in response to SM exposure resulted in clusters of co-regulated metabolites, with glutathione, nitrogen, histidine, vitamin B₃, and aminosugars metabolism identified by variable importance in projection scores. Microgravity-induced metabolic shifts in gel constructs and media were indicative of protein synthesis, energy and nucleotide metabolism, and oxidative catabolism. Microgravity associated-metabolic shifts were consistent with our previously published early osteoarthritic metabolomic profiles in human synovial fluid, suggesting that even short-term exposure to microgravity (or other reduced mechanical loading environments) may lead to the development of OA. This work further suggests the potential to detect these metabolic perturbations in synovial fluid in vivo to ascertain osteoarthritis risk in astronauts.

软骨细胞对减少机械负荷环境和随后发生骨关节炎风险的反应机制尚不清楚。这是宇航员特别关心的问题。在太空中，在长时间的微重力（10-6 g）暴露中关节载荷力的降低可能导致骨关节炎（OA），从而影响航天飞行后的生活质量。在这项研究中，我们将人软骨细胞包裹在一种琼脂糖凝胶中，这种凝胶的硬度与细胞周围基质相似，以模拟软骨微环境。然后，我们使用旋转壁管（RWV）生物反应器将琼脂糖-软骨细胞结构暴露在模拟微重力（SM）中4天，以更好地评估与航天有关的软骨健康风险。从培养基和琼脂糖凝胶结构中提取的代谢物采用液相色谱-质谱法分析。全球代谢组学分析共检测到1205个代谢物特征，其中497个显著代谢物特征通过方差分析（fdr校正的p值3）确定，糖代谢通过预测评分的可变重要性确定。微重力诱导的凝胶结构和培养基的代谢变化表明蛋白质合成、能量和核苷酸代谢以及氧化分解代谢。微重力相关的代谢变化与我们之前发表的人体滑液早期骨关节炎代谢组学特征一致，表明即使短期暴露于微重力（或其他减少机械负荷的环境）也可能导致OA的发展。这项工作进一步表明，有可能检测体内滑液中的这些代谢扰动，以确定宇航员患骨关节炎的风险。

{"title":"Metabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated Microgravity","authors":"Annika R. Bergstrom, Matthew G. Glimm, Eden A. Houske, Gwendolyn Cooper, Ethan Viles, Marrin Chapman, Katherine Bourekis, Hope D. Welhaven, Priyanka P. Brahmachary, Alyssa K. Hahn, Ronald K. June","doi":"10.1007/s10439-024-03667-x","DOIUrl":"10.1007/s10439-024-03667-x","url":null,"abstract":"<div><p>The mechanism by which chondrocytes respond to reduced mechanical loading environments and the subsequent risk of developing osteoarthritis remains unclear. This is of particular concern for astronauts. In space the reduced joint loading forces during prolonged microgravity (10<sup>−6</sup> g) exposure could lead to osteoarthritis (OA), compromising quality of life post-spaceflight. In this study, we encapsulated human chondrocytes in an agarose gel of similar stiffness to the pericellular matrix to mimic the cartilage microenvironment. We then exposed agarose-chondrocyte constructs to simulated microgravity (SM) for four days using a rotating wall vessel (RWV) bioreactor to better assess the cartilage health risks associated with spaceflight. Metabolites extracted from media and agarose gel constructs were analyzed on liquid chromatography-mass spectrometry. Global metabolomic profiling detected a total of 1205 metabolite features, with 497 significant metabolite features identified by ANOVA (FDR-corrected <i>p</i>-value < 0.05). Specific metabolic shifts detected in response to SM exposure resulted in clusters of co-regulated metabolites, with glutathione, nitrogen, histidine, vitamin B<sub>3</sub>, and aminosugars metabolism identified by variable importance in projection scores. Microgravity-induced metabolic shifts in gel constructs and media were indicative of protein synthesis, energy and nucleotide metabolism, and oxidative catabolism. Microgravity associated-metabolic shifts were consistent with our previously published early osteoarthritic metabolomic profiles in human synovial fluid, suggesting that even short-term exposure to microgravity (or other reduced mechanical loading environments) may lead to the development of OA. This work further suggests the potential to detect these metabolic perturbations in synovial fluid <i>in vivo</i> to ascertain osteoarthritis risk in astronauts.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"785 - 797"},"PeriodicalIF":3.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03667-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Impedance and Wave Reflections in Adults with Mitral Stenosis: Immediate and Follow-Up Effects of Balloon Valvuloplasty 成人二尖瓣狭窄的肺阻抗和波反射：球囊瓣膜成形术的即时和随访效果。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-15 DOI: 10.1007/s10439-024-03661-3

Chih-Tai Ting, Jaw-Wen Chen, Mau-Song Chang, Frank C.-P. Yin

Purpose

We compared adults with mitral stenosis (MS) to 8 controls (CONT) to see how pulmonary impedance and wave reflections differ at baseline and after balloon valvuloplasty.

Methods

We separated the MS patients into groups according to mean pulmonary artery pressure: moderate (MOD; ≤ 26 mmHg, n = 21) and high (HIGH; > 26 mmHg, n = 33). We made baseline high-fidelity measurements in all patients, in the MS groups after vasodilation with nitroprusside, immediately and 4 months after balloon valvuloplasty.

Results

Comparing MOD vs CONT, using the Kruskal-Wallis test with Bonferroni correction, reveals evidence for higher baseline input resistance (R) (489 vs 205 dyne-sec/cm⁵, P = 0.07); first harmonic of impedance modulus (Z₁) (97.3 vs 27.6 dyne-sec/cm⁵, P = 0.01); first zero crossing of impedance phase angle (F₀) (4.49° vs 2.19°, P = 0.02) but no difference in wave reflection index (P_b/P_f). Baseline HIGH vs CONT comparisons reveal stronger evidence and larger differences than MOD for R (995 vs 205, P < 0.001); Z₁ (151 vs 27.6, P < 0.001); F₀ (5.25 vs 2.19, P < 0.001); as well as P_b/P_f (0.69 vs 0.42, P < 0.001). Responses to nitroprusside and valvuloplasty are also greater in the HIGH than MOD, but the HIGH parameters still differ from the CONT. Four months after valvuloplasty there is evidence for reverse remodeling in both groups. Further analyses reveal that sinus rhythm and younger age are potentially important factors for remodeling.

Conclusion

MS causes alterations in pulmonary hemodynamics that differ according to pressure levels. These changes are only partially reversed immediately after valvuloplasty. There is evidence for reverse remodeling 4 months afterwards.

目的：我们将患有二尖瓣狭窄（MS）的成年人与 8 名对照组（CONT）进行了比较，以了解肺阻抗和肺波反射在基线和球囊瓣膜成形术后有何不同：我们根据平均肺动脉压将 MS 患者分为两组：中度组（MOD；≤ 26 mmHg，n = 21）和高度组（HIGH；> 26 mmHg，n = 33）。我们对所有患者、硝普钠扩张血管后的 MS 组、球囊瓣膜成形术后立即和 4 个月后的患者进行了基线高保真测量：使用 Kruskal-Wallis 检验和 Bonferroni 校正比较 MOD 和 CONT，结果显示基线输入阻力（R）较高（489 对 205 达因-秒/厘米5，P = 0.07）；阻抗模量（Z1）的第一次谐波（97.3 vs 27.6 戴恩-秒/厘米5，P = 0.01）；阻抗相位角（F0）的第一次零交叉（4.49° vs 2.19°，P = 0.02），但波反射系数（Pb/Pf）没有差异。基线 HIGH 与 CONT 的比较显示，R（995 vs 205，P 1（151 vs 27.6，P 0（5.25 vs 2.19，P b/Pf（0.69 vs 0.42，P 结论：MS 会导致肺血流动力学的改变：多发性硬化会导致肺血流动力学的改变，这些改变因压力水平而异。这些变化在瓣膜成形术后只能立即部分逆转。有证据表明，4 个月后会发生逆向重塑。

{"title":"Pulmonary Impedance and Wave Reflections in Adults with Mitral Stenosis: Immediate and Follow-Up Effects of Balloon Valvuloplasty","authors":"Chih-Tai Ting, Jaw-Wen Chen, Mau-Song Chang, Frank C.-P. Yin","doi":"10.1007/s10439-024-03661-3","DOIUrl":"10.1007/s10439-024-03661-3","url":null,"abstract":"<div><h3>Purpose</h3><p>We compared adults with mitral stenosis (MS) to 8 controls (CONT) to see how pulmonary impedance and wave reflections differ at baseline and after balloon valvuloplasty.</p><h3>Methods</h3><p>We separated the MS patients into groups according to mean pulmonary artery pressure: moderate (MOD; ≤ 26 mmHg, n = 21) and high (HIGH; > 26 mmHg, n = 33). We made baseline high-fidelity measurements in all patients, in the MS groups after vasodilation with nitroprusside, immediately and 4 months after balloon valvuloplasty.</p><h3>Results</h3><p>Comparing MOD vs CONT, using the Kruskal-Wallis test with Bonferroni correction, reveals evidence for higher baseline input resistance (R) (489 vs 205 dyne-sec/cm<sup>5</sup>, P = 0.07); first harmonic of impedance modulus (Z<sub>1</sub>) (97.3 vs 27.6 dyne-sec/cm<sup>5</sup>, P = 0.01); first zero crossing of impedance phase angle (F<sub>0</sub>) (4.49° vs 2.19°, P = 0.02) but no difference in wave reflection index (P<sub>b</sub>/P<sub>f</sub>). Baseline HIGH vs CONT comparisons reveal stronger evidence and larger differences than MOD for R (995 vs 205, P < 0.001); Z<sub>1</sub> (151 vs 27.6, P < 0.001); F<sub>0</sub> (5.25 vs 2.19, P < 0.001); as well as P<sub>b</sub>/P<sub>f</sub> (0.69 vs 0.42, P < 0.001). Responses to nitroprusside and valvuloplasty are also greater in the HIGH than MOD, but the HIGH parameters still differ from the CONT. Four months after valvuloplasty there is evidence for reverse remodeling in both groups. Further analyses reveal that sinus rhythm and younger age are potentially important factors for remodeling.</p><h3>Conclusion</h3><p>MS causes alterations in pulmonary hemodynamics that differ according to pressure levels. These changes are only partially reversed immediately after valvuloplasty. There is evidence for reverse remodeling 4 months afterwards.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"758 - 784"},"PeriodicalIF":3.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03661-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel In Silico–Ex Vivo Model for Correlating Coating Transfer to Tissue with Local Drug-Coated Balloon-Vessel Contact Pressures 一种新颖的硅-离体模型，用于将涂层转移到组织与局部药物涂层气球-血管接触压力相关联。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-12 DOI: 10.1007/s10439-024-03634-6

Efstathios Stratakos, Linnea Tscheuschner, Lorenzo Vincenzi, Edoardo Pedrinazzi, Fragiska Sigala, Luca D’Andrea, Dario Gastaldi, Francesca Berti, Abraham Rami Tzafriri, Giancarlo Pennati

Drug-coated balloons (DCBs) aim to deliver drug-loaded surface coating upon inflation at specific vascular sites, yet the role of inflation pressure remains to be defined. We implement a new approach combining ex vivo stamping experiments with in silico simulations to study acute coating transfer by commercial DCBs. This methodology comprises 3 essential pillars: (I) DCB resin inflation and slicing into cylindrical segments for subsequent stamping onto porcine-excised tissue, (II) Numerical inflation of a full DCB replica in an idealized porcine vessel to predict in vivo interfacial contact pressures (CPs) and subsequent interfacial-level numerical stamping to calculate appropriate benchtop forces that recreate these in vivo CP values, and (III) ex vivo stamping experiments and optical analysis of the stamped surfaces (DCB segment and arterial tissue), using a standard high-resolution camera to visualize coating. High-performance liquid chromatography (HPLC) was employed as a validated assay for quantifying drug in tissue samples post-stamping. HPLC analysis revealed a significant correlation with image processing, confirming the validity of the optical method as a tool to quantify DCB coating. Image and HPLC analysis revealed a statistically significant twofold rise in coating area and drug content to tissue, respectively, when the average CP roughly doubled (0.16–0.35 atm) and a non-statistically significant increase in coating area and drug content with a further rough doubling of average CP (0.35 to 0.75 atm). Imaging of DCB segments pre- and post-stamping showed transfer of partial coating thickness at low CP, contrasting with complete transfer at high CP at the same site. 3D confocal images of DCB surfaces revealed variable thickness in the transferred coating. This study introduces a comprehensive methodology for evaluating the efficacy of commercial DCB coating transfer to arterial tissue—a crucial precursor to drug elution studies—while minimizing the number of DCBs needed and improving variable control and realism.

药物包覆气球（DCBs）的目的是在特定血管部位膨胀时提供载药的表面涂层，但膨胀压力的作用仍有待确定。我们实现了一种结合体外冲压实验和计算机模拟的新方法来研究商业dcb的急性涂层转移。该方法包括三个基本支柱：(I) DCB树脂膨胀并切割成圆柱形段，以便随后冲压到猪切除的组织上；（II）在理想的猪血管中对完整的DCB复制品进行数值膨胀，以预测体内界面接触压力（CPs），并随后进行界面级数值冲压，以计算重现这些体内CP值的适当的台面力；（III）离体冲压实验和冲压表面（DCB段和动脉组织）的光学分析。使用标准的高分辨率相机可视化涂层。采用高效液相色谱法（HPLC）对组织样品中药物进行定量分析。HPLC分析显示了与图像处理的显著相关性，证实了光学方法作为定量DCB涂层的工具的有效性。图像和HPLC分析显示，当平均CP大致增加一倍（0.16-0.35 atm）时，涂层面积和组织中药物含量分别增加了两倍，具有统计学意义；当平均CP进一步大致增加一倍（0.35 - 0.75 atm）时，涂层面积和药物含量增加无统计学意义。DCB节段冲压前后的成像显示低CP处部分涂层厚度转移，而同一部位高CP处完全转移。DCB表面的三维共聚焦图像显示转移涂层的厚度变化。本研究介绍了一种综合的方法来评估商业DCB涂层转移到动脉组织的有效性-药物洗脱研究的关键前体-同时最大限度地减少所需DCB的数量并改善可变控制和真实性。

{"title":"A Novel In Silico–Ex Vivo Model for Correlating Coating Transfer to Tissue with Local Drug-Coated Balloon-Vessel Contact Pressures","authors":"Efstathios Stratakos, Linnea Tscheuschner, Lorenzo Vincenzi, Edoardo Pedrinazzi, Fragiska Sigala, Luca D’Andrea, Dario Gastaldi, Francesca Berti, Abraham Rami Tzafriri, Giancarlo Pennati","doi":"10.1007/s10439-024-03634-6","DOIUrl":"10.1007/s10439-024-03634-6","url":null,"abstract":"<div><p>Drug-coated balloons (DCBs) aim to deliver drug-loaded surface coating upon inflation at specific vascular sites, yet the role of inflation pressure remains to be defined. We implement a new approach combining ex vivo stamping experiments with in silico simulations to study acute coating transfer by commercial DCBs. This methodology comprises 3 essential pillars: (I) DCB resin inflation and slicing into cylindrical segments for subsequent stamping onto porcine-excised tissue, (II) Numerical inflation of a full DCB replica in an idealized porcine vessel to predict in vivo interfacial contact pressures (CPs) and subsequent interfacial-level numerical stamping to calculate appropriate benchtop forces that recreate these in vivo CP values, and (III) ex vivo stamping experiments and optical analysis of the stamped surfaces (DCB segment and arterial tissue), using a standard high-resolution camera to visualize coating. High-performance liquid chromatography (HPLC) was employed as a validated assay for quantifying drug in tissue samples post-stamping. HPLC analysis revealed a significant correlation with image processing, confirming the validity of the optical method as a tool to quantify DCB coating. Image and HPLC analysis revealed a statistically significant twofold rise in coating area and drug content to tissue, respectively, when the average CP roughly doubled (0.16–0.35 atm) and a non-statistically significant increase in coating area and drug content with a further rough doubling of average CP (0.35 to 0.75 atm). Imaging of DCB segments pre- and post-stamping showed transfer of partial coating thickness at low CP, contrasting with complete transfer at high CP at the same site. 3D confocal images of DCB surfaces revealed variable thickness in the transferred coating. This study introduces a comprehensive methodology for evaluating the efficacy of commercial DCB coating transfer to arterial tissue—a crucial precursor to drug elution studies—while minimizing the number of DCBs needed and improving variable control and realism.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"740 - 757"},"PeriodicalIF":3.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10439-024-03634-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing Simulation Approaches Used in Finite Element Modelling of a Medial Opening Wedge High Tibial Osteotomy 胫骨内侧开口楔形高位截骨的有限元模拟方法比较。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-10 DOI: 10.1007/s10439-024-03662-2

Victor A. Carranza, Alan Getgood, Ryan Willing, Timothy A. Burkhart

Purpose

Medial opening wedge high tibial osteotomy is a surgical procedure intended to relieve the symptoms of osteoarthritis in the medial compartment of the knee by addressing malalignment within the structures of the knee. In previous studies, the osteotomy cut and wedge opening in a Medial opening wedge high tibial osteotomy finite element model has been represented using either one of two techniques, which we define herein as wedge opening and wedge removal approaches. The purpose of this study is to determine whether the wedge removal for a medial opening wedge high tibial osteotomy finite element modelling study predicts accurate stresses and strains in the plate, screw, and throughout the proximal tibia, in comparison to the wedge opening.

Methods

Seven tibia models were reconstructed from CT scans of seven cadaveric specimen. Two sets of models were created from the same set of specimens to create the wedge opening (n = 7) and wedge removal (n = 7) dataset.

Results

A statistically significant difference in the mean plate stresses, screw stresses, and stresses in the tibia at the region around the apex of the osteotomy were found with the wedge removal, resulting in 4–59% greater stresses.

Conclusion

The wedge removal is not an accurate representation of a medial opening wedge high tibial osteotomy with respect to the wedge opening. Selecting the appropriate modelling method that best represents the clinical scenario is the first crucial step in creating a representative finite element model.

目的：内侧开口楔形胫骨高位截骨术是一种外科手术，旨在通过解决膝关节结构内的错位来缓解膝关节内侧腔室骨关节炎的症状。在以前的研究中，在内侧开口楔形胫骨高位截骨有限元模型中，截骨切开和楔形开口采用两种技术中的一种来表示，我们在此将其定义为楔形开口和楔形移除入路。本研究的目的是确定楔形移除内侧开口楔形胫骨高位截骨有限元模型研究是否能准确预测钢板、螺钉和整个胫骨近端与楔形开口相比的应力和应变。方法：对7具尸体标本进行CT扫描，重建7个胫骨模型。从同一组标本中创建两组模型，以创建楔形打开（n = 7）和楔形去除（n = 7）数据集。结果：楔形物去除后，截骨顶点周围区域的平均钢板应力、螺钉应力和胫骨应力差异有统计学意义，应力增加4-59%。结论：楔形切除并不能准确地表示内侧开口楔形胫骨高位截骨相对于楔形开口。选择最能代表临床情况的适当建模方法是创建具有代表性的有限元模型的关键第一步。

{"title":"Comparing Simulation Approaches Used in Finite Element Modelling of a Medial Opening Wedge High Tibial Osteotomy","authors":"Victor A. Carranza, Alan Getgood, Ryan Willing, Timothy A. Burkhart","doi":"10.1007/s10439-024-03662-2","DOIUrl":"10.1007/s10439-024-03662-2","url":null,"abstract":"<div><h3>Purpose</h3><p>Medial opening wedge high tibial osteotomy is a surgical procedure intended to relieve the symptoms of osteoarthritis in the medial compartment of the knee by addressing malalignment within the structures of the knee. In previous studies, the osteotomy cut and wedge opening in a Medial opening wedge high tibial osteotomy finite element model has been represented using either one of two techniques, which we define herein as wedge opening and wedge removal approaches. The purpose of this study is to determine whether the wedge removal for a medial opening wedge high tibial osteotomy finite element modelling study predicts accurate stresses and strains in the plate, screw, and throughout the proximal tibia, in comparison to the wedge opening.</p><h3>Methods</h3><p>Seven tibia models were reconstructed from CT scans of seven cadaveric specimen. Two sets of models were created from the same set of specimens to create the wedge opening (<i>n</i> = 7) and wedge removal (<i>n</i> = 7) dataset.</p><h3>Results</h3><p>A statistically significant difference in the mean plate stresses, screw stresses, and stresses in the tibia at the region around the apex of the osteotomy were found with the wedge removal, resulting in 4–59% greater stresses.</p><h3>Conclusion</h3><p>The wedge removal is not an accurate representation of a medial opening wedge high tibial osteotomy with respect to the wedge opening. Selecting the appropriate modelling method that best represents the clinical scenario is the first crucial step in creating a representative finite element model.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"731 - 739"},"PeriodicalIF":3.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Computational Modeling of Blast Transmission through the Fluid-Filled Cochlea and Hair Cells 冲击波通过充满液体的耳蜗和毛细胞传播的三维计算模型。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-08 DOI: 10.1007/s10439-024-03659-x

John J. Bradshaw, Marcus A. Brown, Yijie Jiang, Rong Z. Gan

Purpose

Veterans commonly suffer from blast-induced hearing disabilities. Injury to the sensitive organ of Corti (OC) or hair cells within the cochlea can directly lead to hearing loss, but is very difficult to measure experimentally. Computational finite element (FE) models of the human ear have been used to predict blast wave transmission through the middle ear and cochlea, but these models lack a representation of the OC. This paper reports a recently developed 3D FE model of the OC to simulate the response of hair cells to blast waves and predict possible injury locations.

Methods

Components of the OC model consist of the sensory cells, membranes, and supporting cells with endolymphatic fluid surrounding them inside the scala media. Displacement of the basilar membrane induced by a 31-kPa blast overpressure derived from the macroscale model of the human ear was applied as input to the OC model. The fluid–structure interaction coupled analysis in the time domain was conducted in ANSYS.

Results

Major results derived from the FE model include the strains and displacements of the outer hair cells, stereociliary hair bundles (HBs), reticular lamina, and the tectorial membrane (TcM). The highest structural strain was concentrated around the connecting region of the HBs and the TcM, potentially indicating detachment due to blast exposure. Including the interstitial fluid in the OC created a realistic environment and improved the accuracy of the results compared to the previously published OC model without fluid.

Conclusion

The microscale model of OC was developed in order to simulate blast overpressure transmission through the fluid-filled cochlea and hair cells. This FE model represents a significant advancement in the study of blast wave transmission through the inner ear, and is an important step toward a comprehensive multi-scale model of the human ear that can predict blast-induced injury and hearing loss.

目的：退伍军人通常患有爆炸引起的听力障碍。耳蜗内敏感器官或毛细胞损伤可直接导致听力损失，但实验测量非常困难。人耳的计算有限元模型已被用于预测冲击波通过中耳和耳蜗的传播，但这些模型缺乏对中耳和耳蜗的表征。本文报道了最近开发的一种用于模拟毛细胞对冲击波的反应并预测可能损伤位置的OC三维有限元模型。方法：OC模型的组成部分由感觉细胞、膜和支持细胞组成，细胞周围有内淋巴液。将由人耳宏观模型导出的31 kpa爆炸超压引起的基底膜位移作为OC模型的输入。在ANSYS中进行了时域流固耦合分析。结果：有限元模型得到的主要结果包括外毛细胞、立体纤毛束（HBs）、网状层和毡膜（TcM）的应变和位移。最高的结构应变集中在HBs和TcM的连接区域周围，可能表明爆炸暴露导致的脱离。与之前发表的无流体OC模型相比，在OC中加入间质液创造了一个真实的环境，提高了结果的准确性。结论：建立了模拟爆炸超压通过充液耳蜗和毛细胞传递的微尺度耳蜗模型。该有限元模型代表了爆炸冲击波内耳传播研究的重大进展，是建立能够预测爆炸损伤和听力损失的人耳综合多尺度模型的重要一步。

{"title":"3D Computational Modeling of Blast Transmission through the Fluid-Filled Cochlea and Hair Cells","authors":"John J. Bradshaw, Marcus A. Brown, Yijie Jiang, Rong Z. Gan","doi":"10.1007/s10439-024-03659-x","DOIUrl":"10.1007/s10439-024-03659-x","url":null,"abstract":"<div><h3>Purpose</h3><p>Veterans commonly suffer from blast-induced hearing disabilities. Injury to the sensitive organ of Corti (OC) or hair cells within the cochlea can directly lead to hearing loss, but is very difficult to measure experimentally. Computational finite element (FE) models of the human ear have been used to predict blast wave transmission through the middle ear and cochlea, but these models lack a representation of the OC. This paper reports a recently developed 3D FE model of the OC to simulate the response of hair cells to blast waves and predict possible injury locations.</p><h3>Methods</h3><p>Components of the OC model consist of the sensory cells, membranes, and supporting cells with endolymphatic fluid surrounding them inside the scala media. Displacement of the basilar membrane induced by a 31-kPa blast overpressure derived from the macroscale model of the human ear was applied as input to the OC model. The fluid–structure interaction coupled analysis in the time domain was conducted in ANSYS.</p><h3>Results</h3><p>Major results derived from the FE model include the strains and displacements of the outer hair cells, stereociliary hair bundles (HBs), reticular lamina, and the tectorial membrane (TcM). The highest structural strain was concentrated around the connecting region of the HBs and the TcM, potentially indicating detachment due to blast exposure. Including the interstitial fluid in the OC created a realistic environment and improved the accuracy of the results compared to the previously published OC model without fluid.</p><h3>Conclusion</h3><p>The microscale model of OC was developed in order to simulate blast overpressure transmission through the fluid-filled cochlea and hair cells. This FE model represents a significant advancement in the study of blast wave transmission through the inner ear, and is an important step toward a comprehensive multi-scale model of the human ear that can predict blast-induced injury and hearing loss.</p></div>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":"53 3","pages":"718 - 730"},"PeriodicalIF":3.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments of Healthy and Osteoarthritic Female Joints. 健康女性关节与骨关节炎女性关节的骨斜关节韧带形态学和力学特性差异。

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL

Annals of Biomedical Engineering

Pub Date : 2024-12-07 DOI: 10.1007/s10439-024-03660-4

Lizzie Walker, Daniel Gordon, Alexander Chiaramonti, Shangping Wang, Zhaoxu Meng, Dane Daley, Elizabeth Slate, Hai Yao, Vincent D Pellegrini, Yongren Wu

Purpose: To identify changes in morphological and mechanical properties in the volar ligament complex (VLC), dorsoradial ligaments (DRL), and posterior oblique ligaments (POL) in healthy and osteoarthritic female trapeziometacarpal (TMC) joints.

Methods: Twenty-four fresh-frozen female cadaveric TMCs were separated into (1) younger healthy/early-stage osteoarthritic, (2) elder healthy/early-stage osteoarthritic, and (3) advanced-stage osteoarthritic groups based on age and Eaton-Littler grading. Stress relaxation and load-to-failure testing were performed to characterize mechanical tensile properties. Light imaging and scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS) were performed to further assess enthesis structural integrity.

Results: The VLC in advanced-stage osteoarthritic TMCs had attenuated mechanical properties in stress relaxation experiments compared to the elder healthy/early-stage osteoarthritic specimens: Young's modulus at 20% strain (P = 0.044), instantaneous (P = 0.023), relaxed (P = 0.017) moduli. VLCs in advanced-stage osteoarthritic TMCs also had significantly lower properties in the load-to-failure experiments compared to the younger healthy/early-stage osteoarthritic specimens: stiffness (P = 0.048), ultimate load (P = 0.017), toughness (P = 0.003). Light and SEM/EDS imaging revealed partial detachment and loss of enthesis mineral gradient at VLC metacarpal insertion in advanced-stage osteoarthritic specimens. There were no mechanical or structural changes in the DRL and POL between experiment groups.

Conclusion: VLC morphological and mechanical properties deteriorate across progressively severe osteoarthritis classifications while the DRL and POL remain unchanged. The attenuated mechanical properties of VLCs in advanced-stage osteoarthritic TMCs can be explained by ligament degradation as evidenced by partial detachment and loss of mineral gradient at the metacarpal insertion.

目的：探讨健康女性骨关节炎患者掌侧韧带复合体（VLC）、背桡韧带（DRL）和后斜韧带（POL）形态和力学特性的变化。方法：将24例新鲜冷冻女性尸体tmc按年龄和aton- littler分级分为(1)年轻健康/早期骨关节炎组、(2)老年健康/早期骨关节炎组和(3)晚期骨关节炎组。进行应力松弛和载荷失效测试来表征机械拉伸性能。通过光成像和扫描电子显微镜(SEM)/能谱分析（EDS）进一步评估其结构完整性。结果：在应力松弛实验中，晚期骨关节炎tmc中VLC的力学性能与老年健康/早期骨关节炎标本相比有所减弱：20%应变时的杨氏模量（P = 0.044）、瞬时模量（P = 0.023）、松弛模量（P = 0.017）。与年轻健康/早期骨关节炎样本相比，晚期骨关节炎tmc中的VLCs在载荷-失效实验中的性能也显著降低：刚度（P = 0.048），极限载荷（P = 0.017），韧性（P = 0.003）。在晚期骨关节炎标本中，光和扫描电镜/能谱成像显示VLC掌骨止点部分脱离和内骨矿物梯度丧失。各组间DRL和POL无机械或结构变化。结论：VLC形态学和力学性能在逐渐严重的骨关节炎分类中恶化，而DRL和POL保持不变。晚期骨关节炎tmc中VLCs的力学性能减弱可以通过韧带退化来解释，表现为部分脱离和掌止点矿物梯度的丧失。

{"title":"Morphological and Mechanical Property Differences in Trapeziometacarpal Ligaments of Healthy and Osteoarthritic Female Joints.","authors":"Lizzie Walker, Daniel Gordon, Alexander Chiaramonti, Shangping Wang, Zhaoxu Meng, Dane Daley, Elizabeth Slate, Hai Yao, Vincent D Pellegrini, Yongren Wu","doi":"10.1007/s10439-024-03660-4","DOIUrl":"10.1007/s10439-024-03660-4","url":null,"abstract":"<p><strong>Purpose: </strong>To identify changes in morphological and mechanical properties in the volar ligament complex (VLC), dorsoradial ligaments (DRL), and posterior oblique ligaments (POL) in healthy and osteoarthritic female trapeziometacarpal (TMC) joints.</p><p><strong>Methods: </strong>Twenty-four fresh-frozen female cadaveric TMCs were separated into (1) younger healthy/early-stage osteoarthritic, (2) elder healthy/early-stage osteoarthritic, and (3) advanced-stage osteoarthritic groups based on age and Eaton-Littler grading. Stress relaxation and load-to-failure testing were performed to characterize mechanical tensile properties. Light imaging and scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS) were performed to further assess enthesis structural integrity.</p><p><strong>Results: </strong>The VLC in advanced-stage osteoarthritic TMCs had attenuated mechanical properties in stress relaxation experiments compared to the elder healthy/early-stage osteoarthritic specimens: Young's modulus at 20% strain (P = 0.044), instantaneous (P = 0.023), relaxed (P = 0.017) moduli. VLCs in advanced-stage osteoarthritic TMCs also had significantly lower properties in the load-to-failure experiments compared to the younger healthy/early-stage osteoarthritic specimens: stiffness (P = 0.048), ultimate load (P = 0.017), toughness (P = 0.003). Light and SEM/EDS imaging revealed partial detachment and loss of enthesis mineral gradient at VLC metacarpal insertion in advanced-stage osteoarthritic specimens. There were no mechanical or structural changes in the DRL and POL between experiment groups.</p><p><strong>Conclusion: </strong>VLC morphological and mechanical properties deteriorate across progressively severe osteoarthritis classifications while the DRL and POL remain unchanged. The attenuated mechanical properties of VLCs in advanced-stage osteoarthritic TMCs can be explained by ligament degradation as evidenced by partial detachment and loss of mineral gradient at the metacarpal insertion.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0