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Origami Robotics in Biomedical Applications: A Paradigm Shift in Design and Innovation. 折纸机器人在生物医学中的应用:设计和创新的范式转变。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-18 DOI: 10.1007/s10439-026-04078-w
Ammar Alzaydi

Origami robotics has emerged as a transformative paradigm in biomedical engineering, enabling compact, adaptable, and minimally invasive devices that can perform complex tasks inside the human body. The field integrates principles of origami folding with robotic actuation to address critical challenges in surgery, diagnostics, and therapeutic delivery. The objective of this review is to synthesize recent advances in origami-inspired biomedical systems, highlighting their design principles, fabrication methods, and translational potential. A narrative review approach was adopted, surveying peer-reviewed publications from 2010 to 2025 retrieved from databases such as Scopus, PubMed, and IEEE Xplore using keywords related to origami robotics, biomedical devices, minimally invasive systems, and soft robotics. Across the surveyed literature, origami-based architectures consistently enable extreme miniaturization, enhanced flexibility, and deployable geometries that improve access, localization, and functionality in minimally invasive surgery, targeted drug delivery, diagnostic platforms, and rehabilitation technologies. Key trends include the integration of smart and bioresorbable materials, programmable stiffness, and self-folding mechanisms, alongside persistent challenges in long-term biocompatibility, control precision under physiological uncertainty, and the lack of harmonized performance benchmarks and regulatory pathways. Overall, this review positions origami robotics as a cornerstone of next-generation biomedical device design and argues that future research should focus on advancing bioresponsive materials, adaptive and data-driven control strategies, and regulatory and evaluation frameworks to enable safe and reliable clinical translation.

折纸机器人技术已经成为生物医学工程的一个变革范例,它使紧凑、适应性强、微创的设备能够在人体内执行复杂的任务。该领域将折纸折叠原理与机器人驱动相结合,以解决手术、诊断和治疗交付中的关键挑战。本文综述了折纸生物医学系统的最新进展,重点介绍了其设计原理、制造方法和转化潜力。采用叙述综述的方法,对2010年至2025年同行评议的出版物进行调查,检索自Scopus、PubMed和IEEE Xplore等数据库,使用与折纸机器人、生物医学设备、微创系统和软机器人相关的关键词。在调查的文献中,基于折纸的架构始终能够实现极端小型化,增强灵活性和可部署的几何形状,从而改善微创手术,靶向药物输送,诊断平台和康复技术的访问,定位和功能。主要趋势包括智能和生物可吸收材料的集成、可编程刚度和自折叠机制,以及长期生物相容性、生理不确定性下的控制精度、缺乏统一的性能基准和调节途径等方面的持续挑战。总的来说,这篇综述将折纸机器人定位为下一代生物医学设备设计的基石,并认为未来的研究应该集中在推进生物反应材料、自适应和数据驱动的控制策略以及监管和评估框架上,以实现安全可靠的临床翻译。
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引用次数: 0
Mechanobiological Response of Osteocyte TRPV4 Base on the Piezoelectricity of Bone Matrix. 基于骨基质压电性的骨细胞TRPV4的力学生物学响应。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-17 DOI: 10.1007/s10439-026-04086-w
Shibo Gu, Yuqing Duanwang, Yinuo Zhao, Shuo Gao, Haochen Li, Xinrui Wu, Quanyou Zhang, Yanru Xue, Meng Zhang, Xiaogang Wu, Weiyi Chen

Purpose: Osteocytes are force-sensitive cells possessing a complex lacunar-canalicular system (LCS), embedded within a piezoelectric bone matrix. TRPV4, as a key mechanosensor, plays a crucial role in osteocyte mechanotransduction and related bone disorders. However, the mechanisms underlying its force sensing, mechanical signaling pathways, and biomechanical response remain poorly understood.

Methods: To address this issue, this study established a finite element model incorporating multiple mechanosensors-including bone matrix, LCS, osteocytes, and TRPV4-based on the piezoelectric effect. By integrating the multiphysics coupling of solid mechanics, fluid mechanics, and electric fields to simulate the complex effects on osteocytes, the model calculated stress, strain, and fluid shear stress (FSS) on TRPV4.

Results: Result indicate that piezoelectricity significantly increases stress and strain in TRPV4, particularly FSS. Biomechanical parameters of TRPV4 exhibit significant variations across different locations, with the highest stress levels observed at the cell processes (Maximum increase of approximately 300%). Stress distribution patterns also differ across distinct regions, while stress concentration in TRPV4 primarily occurs in its transmembrane domain and ion channel regions. This study reveals that upon coupling with primary cilia and RhoA, the mechanical response mechanism of TRPV4 undergoes significant alteration. TRPV4 exhibits greater sensitivity to fluid shear stress, whereas Piezo1 responds more strongly to membrane stress.

Conclusions: This study elucidates the microscopic mechanical response mechanism and gating activation mechanism of TRPV4 within complex bone cell environments. It clarifies the interaction mechanisms between TRPV4 and other cellular structures, providing a research pathway for understanding bone cell mechanical transduction mechanisms and complex interactions across multiple scales. This work offers theoretical insights into the pathogenesis and therapeutic approaches for TRPV4-related bone disorders.

目的:骨细胞是一种力敏感细胞,具有复杂的腔隙-管系统(LCS),嵌入压电骨基质中。TRPV4作为一种关键的机械传感器,在骨细胞机械转导及相关骨疾病中起着至关重要的作用。然而,其力传感、机械信号通路和生物力学反应的机制仍然知之甚少。方法:为了解决这一问题,本研究基于压电效应建立了包含骨基质、LCS、骨细胞和trpv4等多个力学传感器的有限元模型。通过整合固体力学、流体力学和电场的多物理场耦合来模拟对骨细胞的复杂影响,该模型计算了TRPV4上的应力、应变和流体剪切应力(FSS)。结果:结果表明,压电显著增加TRPV4的应力和应变,特别是FSS。TRPV4的生物力学参数在不同位置表现出显著差异,在细胞过程中观察到最高的应力水平(最大增加约300%)。不同区域的应力分布模式也不同,而TRPV4的应力集中主要发生在其跨膜结构域和离子通道区域。本研究表明,TRPV4与初级纤毛和RhoA偶联后,机械反应机制发生显著改变。TRPV4对流体剪切应力表现出更大的敏感性,而Piezo1对膜应力的响应更强烈。结论:本研究阐明了TRPV4在复杂骨细胞环境中的微观力学响应机制和门控激活机制。阐明了TRPV4与其他细胞结构的相互作用机制,为理解骨细胞力学转导机制和跨多尺度的复杂相互作用提供了研究途径。这项工作为trpv4相关骨疾病的发病机制和治疗方法提供了理论见解。
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引用次数: 0
Quantitative Analysis of Quadriceps Muscle Forces When Adolescent Females Perform Typical Motions in Soccer or Basketball. 青少年女性进行足球或篮球典型动作时股四头肌力量的定量分析。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-17 DOI: 10.1007/s10439-026-04082-0
Xueying Zhang, Mingxia Gong, Weiyan Ren, Xingyue Wang, Jie Yao, Fang Pu

Purpose: Osgood-Schlatter disease (OSD) is linked to quadriceps traction, yet quantitative force data for adolescent females in high-risk sports is scarce. This study aimed to biomechanically compare quadriceps muscle forces during key motions in female adolescent soccer and basketball players. The objective was to determine which sport's characteristic movements impose greater mechanical loads on the tibial tuberosity, thereby representing a higher potential risk for OSD development.

Methods: Sixteen adolescent females were divided into basketball (n = 8) and soccer (n = 8) groups, each performing three sport-specific motions. Kinematic, kinetic, and electromyography (EMG) data were captured using a 10-camera motion capture system, force plates, and wireless sensors. A musculoskeletal model in OpenSim was employed to estimate and compare peak and accumulated quadriceps muscle forces between the groups and their respective motions.

Results: In basketball, the single-leg jump yielded the highest peak and impulses. For soccer, the side-step cut produced the greatest peak force, and turning yielded the highest accumulated force. Crucially, overall peak quadriceps muscle forces were significantly higher in the soccer group compared to the basketball group. The rectus femoris generated higher peak forces in basketball, while the vasti muscles demonstrated higher peak forces in soccer.

Conclusion: Single-leg jumping in basketball and cutting/turning in soccer impose the most significant traction on the tibial tuberosity. Due to lower overall peak forces, basketball may pose a reduced OSD risk for adolescent females compared to soccer. Differential recruitment of the rectus femoris versus vastus muscles between sports is a key consideration for injury prevention and athlete guidance.

目的:osgood - schater病(OSD)与股四头肌拉伤有关,但青少年女性在高危运动中的定量力数据很少。本研究旨在从生物力学角度比较女性青少年足球运动员和篮球运动员在关键动作中的股四头肌力量。目的是确定哪种运动的特征运动对胫骨结节施加更大的机械负荷,从而代表更高的OSD发展的潜在风险。方法:将16名青少年女性分为篮球组(n = 8)和足球组(n = 8),每组进行3种特定运动动作。运动学、动力学和肌电图(EMG)数据通过10个摄像头运动捕捉系统、测力板和无线传感器采集。使用OpenSim中的肌肉骨骼模型来估计和比较各组及其各自运动之间的峰值和累积股四头肌力量。结果:在篮球运动中,单腿起跳产生的峰值和冲动最高。对于足球来说,侧身切割产生的峰值力最大,而转身产生的累积力最大。至关重要的是,与篮球组相比,足球组的整体四头肌力量峰值明显更高。在篮球运动中,股直肌产生更高的峰值力,而在足球运动中,股大肌显示出更高的峰值力。结论:篮球单腿跳和足球单腿切/转对胫骨粗隆的牵引力最大。由于总体峰值力较低,与足球相比,篮球对青春期女性的OSD风险可能会降低。在不同运动中股直肌和股肌的不同恢复是预防损伤和运动员指导的关键考虑因素。
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引用次数: 0
Characterization of the Ideal Speed of Sound for Plantar Soft Tissue Using Quasi-Simultaneous Ultrasound and Computed Tomography in Cadaveric Feet. 利用准同步超声和尸体足部计算机断层扫描表征足底软组织的理想声速。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-17 DOI: 10.1007/s10439-026-04070-4
Nicholas R Ozanich, Ellen Y Li, Scott Telfer, William R Ledoux

Clinical ultrasound systems typically assume a speed of sound of 1540 m/s for reconstructing images. However, the speed of sound varies between tissues, and this assumption creates distortions and errors in representing the thickness of tissue structures. Quasi-simultaneous (i.e., taken subsequently without movement of the specimen) computed tomography (CT) and ultrasound scans at various speeds of sound (1480, 1540, 1600, and 1660 m/s) were taken at the calcaneus and the second metatarsal head for seven cadaveric feet. A speed of sound of 1600 m/s demonstrated the lowest bias with a mean signed error of - 0.06 mm for the calcaneus and - 0.19 mm for the second metatarsal head, while for 1540 m/s, the calcaneus had a bias of - 0.44 mm, and the second metatarsal head had a bias of - 0.67 mm. The CT-derived distance was used to estimate the ideal speed of sound by calculating the slope of the change in distance with the change in speed of sound and was found to be 1616.6 ± 76.5 m/s for the calcaneus and 1623.9 ± 63.6 m/s for the second metatarsal head. However, limitations in the use of cadavers, CT as the reference standard, and methodological assumptions in analysis limit the extent to which these findings can be generalized to in vivo conditions. This work suggests that using an assumed speed of sound greater than 1540 m/s may be more appropriate for imaging plantar soft tissue; however, additional in vivo studies are needed to corroborate this finding.

临床超声系统通常假设声速为1540米/秒用于重建图像。然而,声音的传播速度因组织而异,这种假设在表示组织结构的厚度时产生了扭曲和错误。以不同声速(1480、1540、1600和1660 m/s)对7只尸体足的跟骨和第二跖骨头进行准同时(即随后在不移动标本的情况下拍摄)计算机断层扫描(CT)和超声扫描。当声速为1600 m/s时,跟骨偏移最小,平均符号误差为- 0.06 mm,第二跖骨偏移为- 0.19 mm,而当声速为1540 m/s时,跟骨偏移为- 0.44 mm,第二跖骨偏移为- 0.67 mm。通过计算距离变化随声速变化的斜率来估计理想声速,发现跟骨为1616.6±76.5 m/s,第二跖骨头为1623.9±63.6 m/s。然而,使用尸体的局限性,CT作为参考标准,以及分析中的方法学假设,限制了这些发现可以推广到体内条件的程度。这项工作表明,假设声速大于1540米/秒可能更适合足底软组织成像;然而,需要更多的体内研究来证实这一发现。
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引用次数: 0
Corticomorphic Hybrid CNN-SNN Architecture for EEG-Based Low-Footprint Low-Latency Auditory Attention Detection. 基于脑电图的低占用低延迟听觉注意检测的皮质形态CNN-SNN混合架构。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-17 DOI: 10.1007/s10439-026-04068-y
Richard Gall, Deniz Kocanaogullari, Murat Akcakaya, Nicole Laffan, Deniz Erdogmus, Rajkumar Kubendran

Purpose: In the context of a multi-speaker "cocktail party" scenario where listeners selectively focus on specific speakers, human auditory attention networks have shown a strong correlation with Electroencephalography (EEG) measurements. However, current EEG-based auditory attention detection (AAD) methods, mostly using artificial neural networks (ANN), face limitations on edge computing platforms due to extended decision windows, high power consumption, and substantial memory requirements linked to multiple EEG channels.

Methods: This paper introduces a novel hybrid convolutional-spiking neural network (CNN-SNN) architecture, inspired by the auditory cortex, combining EEG data with multi-speaker speech envelopes, enabling effective auditory attention decoding within 0.5-s timeframes. Our approach reduces EEG channels, minimizes computational operations, and quantizes weight parameters while maintaining high accuracy.

Results: We validate this approach on our dataset and compare it to state-of-the-art methods on a publicly available dataset. CNN-SNN demonstrates superior performance, achieving up to 10% increase in decoding accuracy, while using 87.5% fewer EEG channels and 75% smaller bit precision for weight quantization compared to existing methods.

Conclusion: These results offer promise for edge computing applications, such as hearing aids, emphasizing short decision windows, minimal EEG channels, and strict power and memory constraints.

目的:在一个多说话的“鸡尾酒会”场景中,听众选择性地关注特定的说话人,人类的听觉注意网络与脑电图(EEG)测量结果显示出很强的相关性。然而,目前基于脑电图的听觉注意检测(AAD)方法大多采用人工神经网络(ANN),由于决策窗口延长、功耗高以及与多个脑电图通道相关的大量内存需求,在边缘计算平台上面临限制。方法:以听觉皮层为灵感,引入了一种新颖的混合卷积-尖峰神经网络(CNN-SNN)架构,将脑电数据与多扬声器语音包络相结合,在0.5 s的时间框架内实现了听觉注意的有效解码。我们的方法减少了EEG通道,最小化了计算操作,并在保持高精度的同时量化了权重参数。结果:我们在我们的数据集上验证了这种方法,并将其与公开可用数据集上最先进的方法进行了比较。CNN-SNN表现出优异的性能,与现有方法相比,解码精度提高了10%,同时使用的EEG通道减少了87.5%,权重量化的比特精度降低了75%。结论:这些结果为边缘计算应用提供了希望,如助听器,强调短决策窗口,最小的EEG通道,严格的功率和内存限制。
{"title":"Corticomorphic Hybrid CNN-SNN Architecture for EEG-Based Low-Footprint Low-Latency Auditory Attention Detection.","authors":"Richard Gall, Deniz Kocanaogullari, Murat Akcakaya, Nicole Laffan, Deniz Erdogmus, Rajkumar Kubendran","doi":"10.1007/s10439-026-04068-y","DOIUrl":"https://doi.org/10.1007/s10439-026-04068-y","url":null,"abstract":"<p><strong>Purpose: </strong>In the context of a multi-speaker \"cocktail party\" scenario where listeners selectively focus on specific speakers, human auditory attention networks have shown a strong correlation with Electroencephalography (EEG) measurements. However, current EEG-based auditory attention detection (AAD) methods, mostly using artificial neural networks (ANN), face limitations on edge computing platforms due to extended decision windows, high power consumption, and substantial memory requirements linked to multiple EEG channels.</p><p><strong>Methods: </strong>This paper introduces a novel hybrid convolutional-spiking neural network (CNN-SNN) architecture, inspired by the auditory cortex, combining EEG data with multi-speaker speech envelopes, enabling effective auditory attention decoding within 0.5-s timeframes. Our approach reduces EEG channels, minimizes computational operations, and quantizes weight parameters while maintaining high accuracy.</p><p><strong>Results: </strong>We validate this approach on our dataset and compare it to state-of-the-art methods on a publicly available dataset. CNN-SNN demonstrates superior performance, achieving up to 10% increase in decoding accuracy, while using 87.5% fewer EEG channels and 75% smaller bit precision for weight quantization compared to existing methods.</p><p><strong>Conclusion: </strong>These results offer promise for edge computing applications, such as hearing aids, emphasizing short decision windows, minimal EEG channels, and strict power and memory constraints.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomechanics of Human Plantar Skin: Experimental and Constitutive Analysis. 人体足底皮肤的生物力学:实验与本构分析。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-14 DOI: 10.1007/s10439-026-04050-8
Chiara Giulia Fontanella, Sofia Pettenuzzo, Alice Berardo, Elisa Belluzzi, Assunta Pozzuoli, Pietro Ruggieri, Emanuele Luigi Carniel

Purpose: Plantar skin is a highly specialised tissue which protects the foot from injuries and adapts to external stresses. However, it can be subjected to diabetic plantar ulcers, which are among the most difficult and costly wounds to treat. Although this is a crucial topic, few studies have focused on the mechanical properties of foot skin and how disease alters them. In this context, this work aims to fully describe the mechanical behavior of plantar skin through experiments and constitutive analysis.

Methods: Different experimental tests (failure tensile tests, unconfined compression at different strain rates, stress relaxation tests) were conducted on human plantar skin samples cut along the posterior-anterior (PA), lateral-medial (LM), and cranial-caudal (CC) directions. Then, experimental results were used to identify, through an inverse analysis, the parameters of the anisotropic visco-hyperelastic constitutive model adopted to describe the skin's mechanical response.

Results: Plantar skin's non-linear, anisotropic, and time-dependent behavior, with differences between the anterior and posterior foot's regions. In addition, the constitutive model adopted is able to capture the mechanical behavior of the plantar skin Failure tensile tests showed that PA directions exhibited higher elastic modulus than LM directions in both posterior (22.05 vs 12.91 MPa) and anterior (17.39 vs 12.82 MPa) regions, while the unconfined compression tests revealed that compressive elastic moduli in the posterior region increased with increasing strain rates.

Conclusion: The proposed model provides new insights into the mechanics of plantar skin, being a valuable tool for applications such as diagnosing skin diseases and developing skin substitutes.

目的:足底皮肤是一种高度专业化的组织,它保护足部免受伤害,并适应外部压力。然而,它可能会导致糖尿病性足底溃疡,这是治疗最困难和最昂贵的伤口之一。虽然这是一个至关重要的话题,但很少有研究关注足部皮肤的机械特性以及疾病如何改变它们。在此背景下,本工作旨在通过实验和本构分析来充分描述足底皮肤的力学行为。方法:对人体足底皮肤后前(PA)、侧内侧(LM)和颅尾(CC)方向进行不同的实验试验(破坏拉伸试验、不同应变率下的无侧限压缩试验、应力松弛试验)。然后,利用实验结果,通过逆分析,确定用于描述皮肤力学响应的各向异性粘-超弹性本构模型的参数。结果:足底皮肤的非线性、各向异性和时间依赖性行为,在前后足区域之间存在差异。此外,所采用的本构模型能够捕捉足底皮肤破坏的力学行为,拉伸试验表明,PA方向在后区(22.05 vs 12.91 MPa)和前区(17.39 vs 12.82 MPa)均表现出高于LM方向的弹性模量,而无侧限压缩试验显示,后区压缩弹性模量随着应变速率的增加而增加。结论:该模型为研究足底皮肤的力学机制提供了新的思路,为皮肤病的诊断和皮肤替代品的开发提供了有价值的工具。
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引用次数: 0
Computational Modeling of Collateral Circulation and Arteriolar Vasodilation in Ischemic Tissue Perfusion. 缺血组织灌注中侧枝循环和小动脉血管扩张的计算模型。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-13 DOI: 10.1007/s10439-026-04052-6
Nolan Moreaux, Chang Min Lee, Bon-Kwon Koo, Keun-Hwa Jung, Jung-Kyu Han, Hyeyeon Chang, Hyun Jin Kim

Purpose: Despite substantial advances in computational cardiovascular modeling, simplifying assumptions often overlook key compensatory mechanisms. To better capture physiological responses under pathological conditions, we incorporate two essential compensatory mechanisms-collateral circulation and arteriolar vasodilation-into a multiscale blood perfusion simulation framework.

Methods: Collateral vessels are stochastically generated to supply ischemic regions, with model parameters systematically varied to control vessel density, caliber, and spatial distribution. Arteriolar vasodilation is modeled to represent the combined response of vascular smooth muscle cells to local metabolic and hemodynamic stimuli. To assess their impact on perfusion, artificial stenoses are introduced into both an idealized geometry and a subject-specific cerebrovascular model.

Results: Simulation results across varying collateral configurations and vasodilation capacities demonstrate that perfusion enhancement from sub-resolution collateral vessels alone is limited and highly dependent on vessel caliber and density. In contrast, combining collateral flow with vasodilation produces a more pronounced improvement in tissue perfusion. These findings suggest that arteriolar vasodilation serves as the primary mechanism for ischemic compensation, with collateral circulation providing secondary support which is consistent with clinical observations.

Conclusion: The proposed methods enable multiscale blood flow simulations while accounting for the main autoregulatory mechanisms. The models have been verified using literature data and are shown to provide accurate results.

目的:尽管计算心血管模型取得了实质性进展,但简化假设往往忽略了关键的代偿机制。为了更好地捕捉病理条件下的生理反应,我们将两个基本的代偿机制-侧支循环和小动脉血管扩张-纳入多尺度血液灌注模拟框架。方法:随机生成侧支血管供应缺血区域,系统改变模型参数,控制血管密度、口径和空间分布。小动脉血管舒张模型代表血管平滑肌细胞对局部代谢和血流动力学刺激的联合反应。为了评估其对灌注的影响,将人工血管狭窄引入理想几何模型和特定受试者的脑血管模型中。结果:不同侧支结构和血管舒张能力的模拟结果表明,仅亚分辨率侧支血管的灌注增强是有限的,并且高度依赖于血管口径和密度。相比之下,将侧支血流与血管舒张相结合可以更明显地改善组织灌注。这些发现表明,小动脉血管扩张是缺血性代偿的主要机制,侧枝循环提供次要支持,这与临床观察一致。结论:所提出的方法可以实现多尺度血流模拟,同时考虑到主要的自动调节机制。这些模型已经使用文献数据进行了验证,并显示出准确的结果。
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引用次数: 0
Field Evaluation of a Wearable Instrumented Headband Designed for Measuring Head Kinematics. 用于测量头部运动学的可穿戴式头带的现场评价。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-13 DOI: 10.1007/s10439-026-04051-7
Anu Tripathi, Yang Wan, Zhiren Zhu, Furkan Camci, Sheila Turcsanyi, Jeneel Pravin Kachhadiya, Mauricio Araiza Canizales, Alison Brooks, Haneesh Kesari, Joseph Andrews, Traci Snedden, Peter Ferrazzano, Christian Franck, Rika Wright Carlsen

Purpose: To study the relationship between soccer heading and the risk of mild traumatic brain injury (mTBI), we previously developed an instrumented headband and data-processing scheme to measure the angular head kinematics of soccer headers. Laboratory evaluation of the headband on an anthropomorphic test device showed good agreement with a reference sensor for soccer ball impacts to the front of the head. In this study, we evaluate the headband in measuring the full head kinematics of soccer headers in the field.

Methods: The headband was evaluated under typical soccer heading scenarios (throw-ins, goal-kicks, and corner-kicks) on a human subject. The measured time history and peak kinematics from the headband were compared with those from an instrumented mouthpiece, which is a widely accepted method for measuring head kinematics in the field.

Results: The time-history agreement (CORA scores) between the headband and the mouthpiece ranged from 'fair' to 'excellent', with the highest agreement for angular velocities (0.79 ± 0.08) and translational accelerations (0.73 ± 0.05) and lowest for angular accelerations (0.67 ± 0.06). A Bland-Altman analysis of the peak kinematics from the headband and mouthpiece found the mean bias to be 40.9 % (of the maximum mouthpiece reading) for the angular velocity, 16.6 % for the translational acceleration, and -14.1 % for the angular acceleration.

Conclusions: The field evaluation of the instrumented headband showed reasonable agreement with the mouthpiece for some kinematic measures and impact conditions. Future work should focus on improving the headband performance across all kinematic measures.

目的:为了研究足球头球与轻度创伤性脑损伤(mTBI)风险之间的关系,我们之前开发了一种仪器头带和数据处理方案来测量足球头球的头部角运动学。在拟人测试装置上对头带进行的实验室评估显示,与足球撞击头部前部的参考传感器非常吻合。在这项研究中,我们评估头带在测量全头部运动学的足球头球在现场。方法:在典型的足球头球场景(界外球、射门和角球)下,对人类受试者的头带进行评估。将头带测量的时程和峰值运动学与仪器吹口测量的时程和峰值运动学进行了比较,这是一种广泛接受的测量头部运动学的方法。结果:头带与牙套的时程一致性(CORA评分)从“一般”到“优秀”,角速度(0.79±0.08)和平移加速度(0.73±0.05)的一致性最高,角加速度(0.67±0.06)的一致性最低。Bland-Altman对头带和吸嘴的峰值运动学分析发现,角速度的平均偏差为40.9%(最大吸嘴读数),平移加速度的平均偏差为16.6%,角加速度的平均偏差为- 14.1%。结论:现场评估显示,在一些运动学测量和冲击条件下,器械头带与牙套具有合理的一致性。未来的工作应该集中在提高头带在所有运动学测量中的性能。
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引用次数: 0
Development of a Patient-Specific Finite Element Analysis for Uncemented Total Hip Arthroplasty: A Step Towards Objective Surgical Planning. 非骨水泥全髋关节置换术患者特异性有限元分析的发展:朝着客观手术计划迈出的一步。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-13 DOI: 10.1007/s10439-026-04033-9
Vineet Seemala, Mark A Williams, Richard King, Arnab Palit

Purpose: Aseptic loosening and intraoperative periprosthetic fractures (IOPPFs) are major complications in uncemented total hip arthroplasty (THA). Computational models for assessing primary stability and IOPPF risk preoperatively are limited. This study developed a patient-specific finite element analysis (FEA) framework that replicates stepwise broaching and implantation in uncemented THA, enabling primary stability assessment and providing a foundation for future IOPPF research.

Methods: A FEA framework was developed using patient-specific femoral geometries and heterogeneous material properties to simulate stepwise broaching and implantation along a defined insertion path. Primary stability was assessed via micromotion under physiological loading. Four case studies were performed to (a) demonstrate the framework using three cadaveric femurs, (b) validate the framework against experimental strain measurements obtained via digital volume correlation (DVC), (c) compare predicted outcomes with a literature-based volumetric expansion model, and (d) assess sensitivity to variations in bone material property models.

Results: Average post-implantation von-Mises stress ranged from 9.87 to 14.77 MPa, with each broach increasing stress and indicating progressive bone compaction. Primary stability, assessed via bone-implant micromotion (29.10-78.04 µm), remained well below the 150 µm threshold, considered favourable for osseointegration. The proposed framework showed closer agreement with experimental DVC strains and compared to the volumetric-expansion model, halved the prediction error. The analysis also demonstrated limited sensitivity to variations in E-ρ models.

Conclusion: The proposed FEA method replicates stepwise broaching and implantation in uncemented THA, enabling patient-specific assessment of bone-implant interactions and primary stability, and providing a foundation for preoperative tools to evaluate IOPPF and aseptic loosening risk and guide tailored femoral implant selection.

目的:无菌性松动和术中假体周围骨折(IOPPFs)是非骨水泥全髋关节置换术(THA)的主要并发症。术前评估初级稳定性和IOPPF风险的计算模型是有限的。本研究开发了一种针对患者的有限元分析(FEA)框架,可在非骨水泥THA中重复逐步拉拔和植入,从而进行初步的稳定性评估,并为未来的IOPPF研究提供基础。方法:利用患者特定的股骨几何形状和异质材料特性开发了FEA框架,以模拟沿确定的插入路径逐步拉削和植入。通过生理负荷下的微动来评估初级稳定性。进行了四个案例研究,以(a)使用三具尸体股骨演示框架,(b)根据通过数字体积相关(DVC)获得的实验应变测量验证框架,(c)将预测结果与基于文献的体积膨胀模型进行比较,以及(d)评估对骨材料特性模型变化的敏感性。结果:种植后平均von-Mises应力范围为9.87 ~ 14.77 MPa,每一次拉刀都增加应力,表明骨压实进展。通过骨植入体微运动(29.10-78.04µm)评估的初级稳定性仍然远低于150µm的阈值,被认为有利于骨整合。所提出的框架与实验DVC菌株更接近,与体积膨胀模型相比,预测误差减少了一半。分析还证明了对E-ρ模型变化的有限敏感性。结论:提出的FEA方法在非骨水泥THA中重复了逐步拉拔和植入,能够根据患者的具体情况评估骨与植入物的相互作用和初级稳定性,并为术前评估IOPPF和无菌松动风险的工具提供基础,并指导量身定制的股骨植入物选择。
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引用次数: 0
Age has No Effect on the Impact Performance of Field-Used Hockey Helmets. 年龄对曲棍球头盔的冲击性能无影响。
IF 5.4 2区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2026-03-13 DOI: 10.1007/s10439-025-03951-4
Craig A Good, Gunter P Siegmund, Janet L Ronsky

Purpose: The goal of our study is to evaluate whether impact attenuation, as measured by peak linear acceleration (PLA), degrades over the expected usage life of field-used hockey helmets at both the certification impact speed of 4.5 m/s and at a lower-severity impact of 3 m/s.

Methods: Field-used helmets were collected from the public and other agencies. The impact testing protocol was adapted from CSA Z262.1-15 and ASTM F1045-16. Helmets were impacted at the rear, side, and front. General linear mixed models were used to assess the effect of age and other covariates (liner material, headform size, helmet wear) on peak linear acceleration.

Results: Over 8000 impact tests were conducted on 762 new and field-used helmets. No significant increases or decreases in PLA with helmet age were observed at any of the impact sites or impact speeds. A few helmet shells cracked in our impact tests.

Conclusion: We evaluated the effect of age on the PLA response of hockey helmets in 4.5 m/s and 3.0 m/s impacts from a large sample of field-used hockey helmets. We found no support for our hypothesis that PLA increases with age. Users should continue to remove helmets from service when they are in poor condition.

目的:我们研究的目的是评估在4.5 m/s的认证冲击速度和3 m/s的较低严重程度的冲击下,使用曲棍球头盔的预期使用寿命期间,以峰值线性加速度(PLA)测量的冲击衰减是否会退化。方法:从公众和其他机构收集现场使用的头盔。冲击试验方案改编自CSA Z262.1-15和ASTM F1045-16。头盔的后部,侧面和前部都有撞击。使用一般线性混合模型来评估年龄和其他协变量(衬垫材料、头型尺寸、头盔佩戴)对峰值线性加速度的影响。结果:对762个新的和现场使用的头盔进行了8000多次冲击试验。在任何撞击地点或撞击速度下,PLA随头盔年龄没有显著的增加或减少。在我们的冲击测试中有几个头盔炮弹破裂了。结论:我们通过大量现场使用的冰球头盔样本,评估了年龄对冰球头盔在4.5 m/s和3.0 m/s撞击下PLA响应的影响。我们没有发现支持我们的假设,即PLA随着年龄的增长而增加。当头盔状况不佳时,用户应继续将其从使用中取下。
{"title":"Age has No Effect on the Impact Performance of Field-Used Hockey Helmets.","authors":"Craig A Good, Gunter P Siegmund, Janet L Ronsky","doi":"10.1007/s10439-025-03951-4","DOIUrl":"https://doi.org/10.1007/s10439-025-03951-4","url":null,"abstract":"<p><strong>Purpose: </strong>The goal of our study is to evaluate whether impact attenuation, as measured by peak linear acceleration (PLA), degrades over the expected usage life of field-used hockey helmets at both the certification impact speed of 4.5 m/s and at a lower-severity impact of 3 m/s.</p><p><strong>Methods: </strong>Field-used helmets were collected from the public and other agencies. The impact testing protocol was adapted from CSA Z262.1-15 and ASTM F1045-16. Helmets were impacted at the rear, side, and front. General linear mixed models were used to assess the effect of age and other covariates (liner material, headform size, helmet wear) on peak linear acceleration.</p><p><strong>Results: </strong>Over 8000 impact tests were conducted on 762 new and field-used helmets. No significant increases or decreases in PLA with helmet age were observed at any of the impact sites or impact speeds. A few helmet shells cracked in our impact tests.</p><p><strong>Conclusion: </strong>We evaluated the effect of age on the PLA response of hockey helmets in 4.5 m/s and 3.0 m/s impacts from a large sample of field-used hockey helmets. We found no support for our hypothesis that PLA increases with age. Users should continue to remove helmets from service when they are in poor condition.</p>","PeriodicalId":7986,"journal":{"name":"Annals of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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