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Association of Prophylactic Antibiotics With Early Infectious Complications in Children With Cancer Undergoing Central Venous Access Device Placement. 预防性抗生素与癌症儿童中心静脉穿刺置管早期感染并发症的相关性。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2023-10-23 DOI: 10.1097/SLA.0000000000006140
Steven T Papastefan, Suhail Zeineddin, Martin L Blakely, Harold N Lovvorn, Lynn Wei Huang, Mehul V Raval, Timothy B Lautz

Objective: To evaluate the impact of prophylactic antibiotics on early infectious complications after central venous access device (VAD) placement in children with cancer.

Background: Despite the frequency of VAD procedures in children, the effectiveness of prophylactic antibiotics for reducing infectious complications is unknown.

Methods: This was a retrospective cohort study of children with cancer undergoing central VAD placement identified in the Pediatric Health Information System database between 2017 and 2021. The primary outcome was the rate of early infectious complications (composite surgical site infections, central line-associated bloodstream infections, and bacteremia). Multivariable logistic regression was used to evaluate factors associated with early infection, and heterogeneity of treatment effect of prophylactic antibiotics was compared across subgroups.

Results: A total of 9216 patients were included (6058 ports and 3158 tunneled lines). Prophylactic antibiotics were associated with lower early infectious complications overall [1.3% vs 2.4%; odds ratio (OR): 0.55 (95% CI: 0.39-0.79), P < 0.001], an effect demonstrated for tunneled lines (OR: 0.59, 95% CI: 0.41-0.84) but not ports (OR: 3.01, 95% CI: 0.66-13.78). On multivariate analysis, prophylactic antibiotics (OR: 0.67, 95% CI: 0.45-0.97) and solid tumors (OR: 0.38, 95% CI: 0.22-0.64) were associated with reduced odds of early infections, whereas tunneled lines (OR: 20.78, 95% CI: 9.83-43.93) and acute myelogenous leukemia (OR: 2.37, 95% CI: 1.58-3.57) had increased odds.

Conclusions: Prophylactic antibiotics are associated with reduced early infectious complications after central VAD placement overall. Despite recommendations from multiple national organizations against prophylactic antibiotics, these findings suggest a benefit in children with malignancy undergoing tunneled line placement.

目的:评价预防性抗生素对癌症儿童中心静脉通路装置(VAD)置入后早期感染性并发症的影响。背景数据摘要:尽管VAD手术在儿童中的频率很高,但预防性抗生素在减少感染并发症方面的有效性尚不清楚。方法:这是一项回顾性队列研究,研究对象为2017-2021年间在儿科健康信息系统数据库中确定的接受中心VAD植入的癌症儿童。主要结果是早期感染并发症(复合手术部位感染、中心线相关血流感染和菌血症)的发生率。多变量逻辑回归用于评估与早期感染相关的因素,并比较各亚组预防性抗生素治疗效果的异质性。结果:包括9216名患者(6058个端口和3158条隧道线路)。预防性抗生素总体上与较低的早期感染并发症相关(1.3%对2.4%;OR 0.55[95%C.I.0.39-0.79]结论:预防性抗生素与中心VAD植入后早期感染并发症的减少有关。尽管多个国家组织建议不要使用预防性抗生素,但这些发现表明,对接受隧道线植入的恶性肿瘤儿童有益。
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引用次数: 0
Whole Blood and Blood Component Resuscitation in Trauma: Interaction and Association With Mortality. 创伤中的全血和血液成分复苏:与死亡率的相互作用和关联。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2024-05-06 DOI: 10.1097/SLA.0000000000006316
Ander Dorken-Gallastegi, Phillip C Spinella, Matthew D Neal, Christine Leeper, Jason Sperry, Andrew B Peitzman, Joshua B Brown

Objective: To evaluate the interaction between whole blood (WB) and blood component resuscitation in relation to mortality after trauma.

Background: WB is increasingly available in civilian trauma resuscitation, and it is typically transfused concomitantly with blood components. The interaction between WB and blood component transfusions is unclear.

Methods: Adult patients with trauma with a shock index >1 who received ≥4 combined units of red blood cells and/or WB within 4 hours across 501 U.S. trauma centers were included using the American College of Surgeons Trauma Quality Improvement Program database. The associations between (1) WB resuscitation and mortality, (2) WB to total transfusion volume ratio (WB:TTV) and mortality, and (3) balanced blood component transfusion in the setting of combined WB and component resuscitation and mortality were evaluated with multivariable analysis.

Results: A total of 12,275 patients were included (WB: 2884 vs component-only: 9391). WB resuscitation was associated with lower odds of 4-hour [adjusted odds ratio: 0.81 (0.68-0.97)], 24-hour, and 30-day mortality compared with component-only. Higher WB:TTV ratios were significantly associated with lower 4-hour, 24-hour, and 30-day mortality, with a 13% decrease in odds of 4-hour mortality for each 10% increase in the WB:TTV ratio [0.87 (95% CI: 0.80-0.94)]. Balanced blood component transfusion was associated with significantly lower odds of 4-hour [adjusted odds ratio: 0.45 (95% CI: 0.29-0.68)], 24-hour, and 30-day mortality in the setting of combined WB and blood component resuscitation.

Conclusions: WB resuscitation, higher WB:TTV ratios, and balanced blood component transfusion in conjunction with WB were associated with lower mortality in patients with trauma presenting in shock requiring at least 4 units of red blood cells and/or WB transfusion within 4 hours of arrival.

目的:评估全血(WB)和血液成分复苏在创伤后死亡率方面的相互作用:评估全血(WB)和血液成分复苏之间的相互作用与创伤后死亡率的关系:全血越来越多地应用于民用创伤复苏,通常与血液成分同时输注。WB 与输血成分之间的相互作用尚不清楚:方法:利用美国外科学院创伤质量改进项目(ACS-TQIP)数据库,纳入了美国 501 个创伤中心中休克指数大于 1 且在 4 小时内接受红细胞(RBC)或白细胞联合单位≥4 个的成人创伤患者。通过多变量分析评估了 1)红细胞复苏与死亡率;2)红细胞与总输血量比率(WB:TTV)与死亡率;3)在合并红细胞和成分复苏的情况下平衡输血成分与死亡率之间的关系:结果:共纳入了 12,275 例患者(WB:2,884 例,纯成分:9,391 例)。与单纯成分复苏相比,WB复苏与较低的4小时死亡率(调整赔率[aOR]:0.81 [0.68-0.97])、24小时死亡率和30天死亡率相关。WB:TTV 比率越高,4 小时、24 小时和 30 天死亡率越低,WB:TTV 比率每增加 10%,4 小时死亡率降低 13%(0.87 [95%CI:0.80 - 0.94])。在WB和血液成分联合复苏的情况下,均衡输血成分与4小时(aOR:0.45 [95%CI:0.29 - 0.68])、24小时和30天死亡率的显著降低相关:结论:对于需要在到达后 4 小时内输注 4 个单位红细胞和/或白细胞的休克创伤患者而言,白细胞复苏、较高的白细胞:TTV 比率以及在输注白细胞的同时输注平衡的血液成分与较低的死亡率相关。
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引用次数: 0
Presbyopia in Surgeons: Ergonomic Impact and Tips for Management. 外科医生的老花眼:人体工程学的影响和管理技巧。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2024-05-08 DOI: 10.1097/SLA.0000000000006323
Amy D Zhang, Brittany Boland, Kristin L Chrouser
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引用次数: 0
Improving Environmental Sustainability of Operating Theatres: A Systematic Review of Staff Attitudes, Barriers, and Enablers. 提高经营中剧院的环境可持续性:对员工态度、障碍和推动因素的系统性研究。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2024-05-10 DOI: 10.1097/SLA.0000000000006337
Siya Lodhia, Victoria Pegna, Ruth Abrams, Daniel Jackson, Timothy A Rockall, Chantelle Rizan

Objective: To understand views of staff in relation to attitudes, enablers, and barriers to implementation of environmentally sustainable surgery in operating theatres. This will ultimately help in the goal of successfully implementing more sustainable theatres.

Background: Global health care sectors are responsible for 4.4% of greenhouse gas emissions. Surgical operating theatres are resource intensive areas and improvements will be important to meet Net-Zero carbon emissions within health care.

Methods: Three databases were searched (Web of Science, Ovid, and PubMed), last checked January 2024. We included original manuscripts evaluating staff views regarding sustainable operating theatres. The Mixed Methods Appraisal Tool was used for quality appraisal and data analysed using thematic synthesis.

Results: A total of 2933 articles were screened and 14 fulfilled inclusion criteria, using qualitative (1), quantitative (2), and mixed methods (11). Studies were undertaken in a variety of clinical (Department of Anaesthesia, Surgery, Otolaryngology, Obstetrics and Gynaecology and Ophthalmology) and geographical settings (Australia, Canada, France, Germany, New Zealand, United States, United Kingdom, and Ireland). Across studies there was a lack of evidence exploring enablers to implementation, but barriers mainly related to the following themes: education and awareness, leadership, resistance to change, facilities and equipment, time, and incentive.

Conclusions: This systematic review identified attitudes and barriers perceived by clinicians towards improving environmental sustainability within operating theatres, which may inform future strategy towards sustainable surgery. Most studies used a survey-design, whereas use of interviews may provide deeper insights. Future work should be extended to wider stakeholders influencing operating theatres. In addition, implementation studies should be carried out to examine whether barriers do change in practice.

目的了解员工对手术室实施环境可持续外科手术的态度、促进因素和障碍的看法。这将最终有助于实现在手术室成功实施更具可持续性的手术的目标:全球医疗保健行业排放的温室气体占总排放量的 4.4%。手术室是资源密集型区域,要实现医疗保健领域的净零碳排放,改进手术室非常重要:搜索了三个数据库(Web of Science、Ovid 和 PubMed),最后一次检查时间为 2024 年 1 月。我们收录了评估员工对可持续手术室看法的原稿。结果:共筛选出 2933 篇文章,其中 14 篇符合纳入标准,采用了定性方法(1 篇)、定量方法(2 篇)和混合方法(11 篇)。研究在不同的临床(麻醉科、外科、耳鼻喉科、妇产科和眼科)和地理环境(澳大利亚、加拿大、法国、德国、新西兰、美国、英国和爱尔兰)中进行。在所有研究中,缺乏探讨实施障碍的证据,但障碍主要涉及以下主题:教育和意识、领导力、变革阻力、设施和设备、时间和激励:本系统性综述确定了临床医生对改善手术室环境可持续性的态度和障碍,可为未来的可持续外科战略提供参考。大多数研究采用了调查设计,而访谈可能会提供更深入的见解。未来的工作应扩展到影响手术室的更广泛的利益相关者。此外,还应该开展实施研究,以考察障碍是否会在实践中发生改变。本系统性综述确定了临床医生对改善手术室环境可持续性的态度和障碍,可为未来的可持续外科战略提供参考。大多数研究采用了调查设计,而访谈可能会提供更深入的见解。未来的工作应扩展到影响手术室的更广泛的利益相关者。此外,还应该开展实施研究,以考察障碍是否会在实践中发生改变。
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引用次数: 0
Improving Shared Decision-making in Situations of Uncertainty: Adopting Lessons From "The Equipoise Ruler". 改善不确定情况下的共同决策:从 "等价交换尺 "中吸取经验教训。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2024-07-22 DOI: 10.1097/SLA.0000000000006456
Mary E Brindle
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引用次数: 0
The Association Between Pediatric Readiness and Mortality for Injured Children Treated at US Trauma Centers. 在美国创伤中心接受治疗的受伤儿童的儿科准备情况与死亡率之间的关系。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2023-10-26 DOI: 10.1097/SLA.0000000000006126
Caroline Melhado, Katherine Remick, Amy Miskovic, Bhavin Patel, Hilary A Hewes, Craig D Newgard, Avery B Nathens, Charles Macias, Lisa Gray, Brian K Yorkgitis, Michael W Dingeldein, Aaron R Jensen

Objective: To use updated 2021 weighted Pediatric Readiness Score (wPRS) data to identify a threshold level of trauma center emergency department (ED) pediatric readiness.

Background: Most children in the United States receive initial trauma care at nonpediatric centers. The aim of the National Pediatric Readiness Project (NPRP) was to ensure that all EDs are prepared to provide quality care for children. Trauma centers reporting the highest quartile of wPRS on the 2013 national assessment have been shown to have lower mortality. Significant efforts have been invested to improve pediatric readiness in the past decade.

Study design: A retrospective cohort of trauma centers that completed the NPRP 2021 national assessment and contributed to the National Trauma Data Bank (NTDB) from 2019 to 2021 was analyzed. Center-specific observed-to-expected mortality estimates for children (0-15 y) were calculated using Pediatric Trauma Quality Improvement Program models. Deterministic linkage was used for transferred patients to account for wPRS at the initial receiving center. Center-specific mortality odds ratios were then compared across quartiles of wPRS.

Results: A total of 66,588 children from 630 centers with a median (interquartile range) wPRS of 79 (66-93) were analyzed. The average observed-to-expected odds of mortality [1.02 (0.97-1.06)] for centers in the highest quartile (wPRS≥93) was lower than any of the lowest 3 wPRS quartiles [1.19 (1.14-1.23) (Q1), 1.29 (1.24-1.33) (Q2), and 1.28 (1.19-1.36) (Q3), all P <0.05). The presence of a pediatric-specific quality improvement plan was the domain with the strongest independent association with mortality [standardized beta -0.095 (-0.146 to -0.044)].

Conclusion: Trauma centers should address gaps in pediatric readiness to include a pediatric-specific quality improvement plan and aim to achieve wPRS ≥93.

目的:使用更新的2021年加权儿科准备程度评分(wPRS)数据来确定创伤中心急诊科(ED)儿科准备程度的阈值水平。背景数据摘要:美国大多数儿童在非儿科中心接受初步创伤护理。国家儿科准备项目(NPRP)旨在确保所有急诊科做好为儿童提供优质护理的准备。在2013年的国家评估中,创伤中心报告的wPRS最高四分位数已被证明死亡率较低。在过去的十年里,已经投入了大量的努力来提高儿科的准备程度。研究设计:对2019-21年完成NPRP 2021国家评估并向国家创伤数据库(NTDB)捐款的创伤中心的回顾性队列进行了分析。使用儿科TQIP模型计算儿童(0-15y)的中心特异性观察到的预期死亡率估计值。转移患者在最初的接收中心使用确定性联系来解释wPRS。然后在wPRS的四分位数之间比较中心特异性死亡率比值比。结果:分析了来自630个中心的66588名儿童,平均[IQR]wPRS为79[66-93]。最高四分位数(wPRS≥93)的中心观察到的平均死亡率与预期死亡率(1.02[0.97-1.06])低于最低三个wPRS四分位数中的任何一个(1.19[1.14-12.3](Q1)、1.29[1.24-13.3](Q2)和1.28[1.19-1.36](Q3),所有结论:创伤中心应解决儿科准备工作的差距,包括儿科特定的质量改进计划,并旨在实现wPRS≥93。
{"title":"The Association Between Pediatric Readiness and Mortality for Injured Children Treated at US Trauma Centers.","authors":"Caroline Melhado, Katherine Remick, Amy Miskovic, Bhavin Patel, Hilary A Hewes, Craig D Newgard, Avery B Nathens, Charles Macias, Lisa Gray, Brian K Yorkgitis, Michael W Dingeldein, Aaron R Jensen","doi":"10.1097/SLA.0000000000006126","DOIUrl":"10.1097/SLA.0000000000006126","url":null,"abstract":"<p><strong>Objective: </strong>To use updated 2021 weighted Pediatric Readiness Score (wPRS) data to identify a threshold level of trauma center emergency department (ED) pediatric readiness.</p><p><strong>Background: </strong>Most children in the United States receive initial trauma care at nonpediatric centers. The aim of the National Pediatric Readiness Project (NPRP) was to ensure that all EDs are prepared to provide quality care for children. Trauma centers reporting the highest quartile of wPRS on the 2013 national assessment have been shown to have lower mortality. Significant efforts have been invested to improve pediatric readiness in the past decade.</p><p><strong>Study design: </strong>A retrospective cohort of trauma centers that completed the NPRP 2021 national assessment and contributed to the National Trauma Data Bank (NTDB) from 2019 to 2021 was analyzed. Center-specific observed-to-expected mortality estimates for children (0-15 y) were calculated using Pediatric Trauma Quality Improvement Program models. Deterministic linkage was used for transferred patients to account for wPRS at the initial receiving center. Center-specific mortality odds ratios were then compared across quartiles of wPRS.</p><p><strong>Results: </strong>A total of 66,588 children from 630 centers with a median (interquartile range) wPRS of 79 (66-93) were analyzed. The average observed-to-expected odds of mortality [1.02 (0.97-1.06)] for centers in the highest quartile (wPRS≥93) was lower than any of the lowest 3 wPRS quartiles [1.19 (1.14-1.23) (Q1), 1.29 (1.24-1.33) (Q2), and 1.28 (1.19-1.36) (Q3), all P <0.05). The presence of a pediatric-specific quality improvement plan was the domain with the strongest independent association with mortality [standardized beta -0.095 (-0.146 to -0.044)].</p><p><strong>Conclusion: </strong>Trauma centers should address gaps in pediatric readiness to include a pediatric-specific quality improvement plan and aim to achieve wPRS ≥93.</p>","PeriodicalId":8017,"journal":{"name":"Annals of surgery","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41189268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Major Pregnancy Complications in Female Cardiothoracic Surgeons. 心胸外科女医生主要妊娠并发症的风险因素。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2024-05-24 DOI: 10.1097/SLA.0000000000006364
Anna Olds, Sameer Hirji, Manuel Castillo-Angeles, Lauren Kane, Jennifer Romano, Cynthia Herrington, Erika Rangel

Objective: To describe the incidence of and risk factors for pregnancy complications in female cardiothoracic surgeons compared with women of similar sociodemographic profiles.

Background: Female cardiothoracic surgeons often postpone childbearing, but little is known about their pregnancy outcomes.

Methods: In 2023, a self-administered survey was distributed to US cardiothoracic surgeons/trainees. Surgeons with ≥1 live birth were queried on maternal work hours during pregnancy and major antenatal pregnancy complications. Male surgeons answered on behalf of non-surgeon childbearing partners (female non-surgeons).

Results: The study included 255 surgeons (63.53% male; 36.47% female). Compared with female surgeons, male surgeons more often had partners who were not employed outside the home (25.64% vs 13.33%, P <0.001). Female surgeons were older than female non-surgeons at first live birth (34.49±4.41 vs 31.45±4.16, P <0.001), more often worked >60 h/wk during pregnancy (70.33% vs 14.08%, P <0.001), and more often had pregnancy complications (45.16% vs 27.16%, P =0.003; operating room (OR): 1.78, 95% CI: 1.01-3.13). Among female surgeons, 18.28% reduced work hours during pregnancy. During their third trimester, 54.84% worked >6 overnight calls/mo, and 72.04% operated >12 h/wk. Age ≥35 years (OR: 3.28, 95% CI: 1.27-8.45) and operating >12 h/wk during the third trimester (OR: 3.72, 95% CI: 1.04-13.30) were associated with pregnancy complications.

Conclusions: Female cardiothoracic surgeons are more likely to experience major pregnancy complications than non-surgeon partners of their male peers. Long operative hours during pregnancy and older maternal age are significant risk factors for pregnancy complications. To advance gender equity, policies to protect maternal-fetal health and facilitate childbearing during training and early career are needed.

目的描述心胸外科女医生与具有相似社会人口学特征的女性相比,其妊娠并发症的发生率和风险因素:心胸外科女医生通常会推迟生育,但对她们的妊娠结局却知之甚少:方法:在 2023 年向美国心胸外科医生/实习生发放了一份自填式调查问卷。调查询问了活产≥1 例的外科医生孕期的工作时间和产前主要妊娠并发症。男外科医生代表非外科医生的育龄伴侣(非外科医生的女性)作答:研究包括 255 名外科医生(63.53% 为男性;36.47% 为女性)。与女外科医生相比,男外科医生的伴侣更经常不在家工作(25.64% 对 13.33%,怀孕期间每周工作 60 小时(70.33% 对 14.08%,每月通宵出诊 6 次,72.04% 每周工作 12 小时以上)。年龄35yrs(OR 3.28,95%CI 1.27-8.45)和怀孕三个月期间每周手术时间>12小时(OR 3.72,95%CI 1.04-13.30)与妊娠并发症有关:结论:与非外科医生的男性同行相比,心胸外科女医生更有可能出现重大妊娠并发症。妊娠期手术时间长和产妇年龄大是导致妊娠并发症的重要风险因素。为了促进性别平等,需要制定政策保护母胎健康,并在培训期间和职业生涯早期为生育提供便利。
{"title":"Risk Factors for Major Pregnancy Complications in Female Cardiothoracic Surgeons.","authors":"Anna Olds, Sameer Hirji, Manuel Castillo-Angeles, Lauren Kane, Jennifer Romano, Cynthia Herrington, Erika Rangel","doi":"10.1097/SLA.0000000000006364","DOIUrl":"10.1097/SLA.0000000000006364","url":null,"abstract":"<p><strong>Objective: </strong>To describe the incidence of and risk factors for pregnancy complications in female cardiothoracic surgeons compared with women of similar sociodemographic profiles.</p><p><strong>Background: </strong>Female cardiothoracic surgeons often postpone childbearing, but little is known about their pregnancy outcomes.</p><p><strong>Methods: </strong>In 2023, a self-administered survey was distributed to US cardiothoracic surgeons/trainees. Surgeons with ≥1 live birth were queried on maternal work hours during pregnancy and major antenatal pregnancy complications. Male surgeons answered on behalf of non-surgeon childbearing partners (female non-surgeons).</p><p><strong>Results: </strong>The study included 255 surgeons (63.53% male; 36.47% female). Compared with female surgeons, male surgeons more often had partners who were not employed outside the home (25.64% vs 13.33%, P <0.001). Female surgeons were older than female non-surgeons at first live birth (34.49±4.41 vs 31.45±4.16, P <0.001), more often worked >60 h/wk during pregnancy (70.33% vs 14.08%, P <0.001), and more often had pregnancy complications (45.16% vs 27.16%, P =0.003; operating room (OR): 1.78, 95% CI: 1.01-3.13). Among female surgeons, 18.28% reduced work hours during pregnancy. During their third trimester, 54.84% worked >6 overnight calls/mo, and 72.04% operated >12 h/wk. Age ≥35 years (OR: 3.28, 95% CI: 1.27-8.45) and operating >12 h/wk during the third trimester (OR: 3.72, 95% CI: 1.04-13.30) were associated with pregnancy complications.</p><p><strong>Conclusions: </strong>Female cardiothoracic surgeons are more likely to experience major pregnancy complications than non-surgeon partners of their male peers. Long operative hours during pregnancy and older maternal age are significant risk factors for pregnancy complications. To advance gender equity, policies to protect maternal-fetal health and facilitate childbearing during training and early career are needed.</p>","PeriodicalId":8017,"journal":{"name":"Annals of surgery","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatic Cancer: An Exocrine Tumor With Endocrine Characteristics. 胰腺癌:具有内分泌特征的外分泌肿瘤。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2023-12-05 DOI: 10.1097/SLA.0000000000006168
Xinzhe Zhu, Zhiwen Xiao, He Liu, Pin Zhang, Shengming Deng, Lei Ding, Jingjing Feng, Jianfeng Luo, Quanxing Ni, Guopei Luo, Xianjun Yu

Objective: To examine the characteristics of patients with pancreatic cancer with long-term survival.

Background: Although pancreatic cancer is a highly lethal malignancy, a minority of patients experience long-term survival. The characteristics of these patients remain largely unidentified.

Methods: An indolent subgroup was established using carbohydrate antigen 19-9 (CA19-9), which is the best-validated biomarker for pancreatic cancer. Of 1558 patients, 13.9% were included in the CA19-9-normal (≤37 U/mL) subgroup.

Results: A normal CA19-9 level was an independent variable for overall survival (median survival, 18.1 vs 9.7 months, hazard ratio = 0.53, P < 0.001). The 5-year survival of patients with stage IV CA19-9-normal cancer was higher than that of patients with stage I-IV CA19-9-high cancer (22.4% vs 6.8%, P = 0.034). The CA19-9-normal subgroup exhibited reduced levels of circulating glucose ( P < 0.001) and increased expression of insulin ( P < 0.001) compared with the CA19-9-high subgroup. Glucose was a substrate for CA19-9 biosynthesis through the hexosamine biosynthesis pathway. In addition, in pancreatic cancer animal models of diabetes, glucose control decreased CA19-9 levels and improved overall survival. In a clinical trial (NCT05306028) of patients before undergoing major anticancer treatments, glucose control decreased CA19-9 levels in 90.9% of the patients.

Conclusions: CA19-9-normal pancreatic cancer is a strikingly indolent subgroup with low glucose and high insulin. Glucose control is a promising therapeutic strategy for pancreatic cancer.

目的:探讨胰腺癌患者长期生存的特点。背景:虽然胰腺癌是一种高度致命的恶性肿瘤,但少数患者能够长期生存。这些患者的特征在很大程度上仍未确定。方法:采用经验证的胰腺癌生物标志物碳水化合物抗原19-9 (CA19-9)建立无痛亚组。1558例患者中,13.9%属于ca19 -9正常(≤37 U/mL)亚组。结果:正常的A19-9水平是总生存期的自变量(中位生存期,18.1个月vs. 9.7个月,风险比= 0.53,P < 0.001)。IV期ca19 -9正常癌患者的5年生存率高于I-IV期ca19 -9高癌患者(22.4%比6.8%,P = 0.034)。与ca19 -9高亚组相比,ca19 -9正常亚组表现出循环葡萄糖水平降低(P < 0.001)和胰岛素表达增加(P < 0.001)。葡萄糖是通过己糖胺生物合成途径进行CA19-9生物合成的底物。此外,在糖尿病的胰腺癌动物模型中,葡萄糖控制降低了CA19-9水平,提高了总生存率。在一项临床试验(NCT05306028)中,在接受主要抗癌治疗前,90.9%的患者血糖控制降低了CA19-9水平。结论:ca19 -9正常胰腺癌是一个明显的低糖高胰岛素的惰性亚组。血糖控制是一种很有前途的治疗胰腺癌的策略。
{"title":"Pancreatic Cancer: An Exocrine Tumor With Endocrine Characteristics.","authors":"Xinzhe Zhu, Zhiwen Xiao, He Liu, Pin Zhang, Shengming Deng, Lei Ding, Jingjing Feng, Jianfeng Luo, Quanxing Ni, Guopei Luo, Xianjun Yu","doi":"10.1097/SLA.0000000000006168","DOIUrl":"10.1097/SLA.0000000000006168","url":null,"abstract":"<p><strong>Objective: </strong>To examine the characteristics of patients with pancreatic cancer with long-term survival.</p><p><strong>Background: </strong>Although pancreatic cancer is a highly lethal malignancy, a minority of patients experience long-term survival. The characteristics of these patients remain largely unidentified.</p><p><strong>Methods: </strong>An indolent subgroup was established using carbohydrate antigen 19-9 (CA19-9), which is the best-validated biomarker for pancreatic cancer. Of 1558 patients, 13.9% were included in the CA19-9-normal (≤37 U/mL) subgroup.</p><p><strong>Results: </strong>A normal CA19-9 level was an independent variable for overall survival (median survival, 18.1 vs 9.7 months, hazard ratio = 0.53, P < 0.001). The 5-year survival of patients with stage IV CA19-9-normal cancer was higher than that of patients with stage I-IV CA19-9-high cancer (22.4% vs 6.8%, P = 0.034). The CA19-9-normal subgroup exhibited reduced levels of circulating glucose ( P < 0.001) and increased expression of insulin ( P < 0.001) compared with the CA19-9-high subgroup. Glucose was a substrate for CA19-9 biosynthesis through the hexosamine biosynthesis pathway. In addition, in pancreatic cancer animal models of diabetes, glucose control decreased CA19-9 levels and improved overall survival. In a clinical trial (NCT05306028) of patients before undergoing major anticancer treatments, glucose control decreased CA19-9 levels in 90.9% of the patients.</p><p><strong>Conclusions: </strong>CA19-9-normal pancreatic cancer is a strikingly indolent subgroup with low glucose and high insulin. Glucose control is a promising therapeutic strategy for pancreatic cancer.</p>","PeriodicalId":8017,"journal":{"name":"Annals of surgery","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138481819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Looking Across the Drape: A Novel Quality Improvement Approach to Understanding Surgeon and Anesthesiologist Burnout. 透过窗帘看世界:了解外科医生和麻醉师职业倦怠的新颖质量改进方法。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1097/SLA.0000000000006241
Jina L Sinskey, Rachel Schwartz, Christy K Boscardin, Joyce M Chang, Sandhya B Kumar, Carter C Lebares

Objective: To identify well-being threats for surgeons and anesthesiologists and develop interventions using the quality of life improvement (QOLI) approach.

Background: Developing feasible perioperative well-being interventions requires identifying shared and specialty-specific well-being needs. The QOLI framework integrates human-centered design, implementation science, and quality improvement to address well-being needs.

Methods: Anesthesia and surgery faculty in 8 perioperative departments at an academic medical center completed cross-sectional surveys containing validated measures of well-being and workplace satisfaction, and open-ended questions about professional motivations, pain points, strategies for improvement, and well-being priorities. Using template analysis, we analyzed open-ended survey data and presented resulting themes at a joint-specialty town hall for live voting to identify well-being priorities.

Results: One hundred four perioperative faculty completed the survey. Across specialties, higher Mental Health Continuum-Short Form scores (representative of individual global well-being) were associated with higher satisfaction with workplace control, values, decision latitude, and social support. Anesthesiologists reported lower satisfaction and control than surgeons across multiple domains. Template analysis yielded 5 areas for intervention: (1) work culture, (2) work environment/resources, (3) sources of fulfillment, (4) work/life harmony, and (5) financial compensation. Surgeons and anesthesiologists both prioritized high-quality patient care but differed in their other top priorities. The most frequently cited well-being threats for surgeons were operating room inefficiencies/delays and excessive workload, whereas anesthesiologists cited understaffing and unpredictable work hours.

Conclusions: Surgeons and anesthesiologists share many needs and priorities, with pain points that are often negatively synergistic. Applying the QOLI approach across specialties allows for well-being interventions that honor complexity and promote the development of feasible solutions.

摘要确定对外科医生和麻醉师福祉的威胁,并采用提高生活质量(QOLI)的方法制定干预措施:背景:制定可行的围手术期福利干预措施需要确定共同的和特定专业的福利需求。QOLI 框架整合了以人为本的设计、实施科学和质量改进,以满足福利需求:一家学术医疗中心八个围手术期科室的麻醉和外科教员完成了横断面调查,调查内容包括经过验证的幸福感和工作场所满意度测量方法,以及有关职业动机、痛点、改进策略和幸福感优先事项的开放式问题。通过模板分析法,我们对开放式调查数据进行了分析,并在联合专科全体会议上提出了由此产生的主题,供现场投票确定福利优先事项:结果:104 名围手术期教师完成了调查。在各专科中,较高的 MHC-SF 分数(代表个人的总体幸福感)与较高的工作场所控制满意度、价值观、决策空间和社会支持有关。麻醉科医生在多个领域的满意度和控制力均低于外科医生。模板分析得出了五个需要干预的领域:(1)工作文化;(2)工作环境/资源;(3)成就感的来源;(4)工作/生活的和谐;(5)经济补偿。外科医生和麻醉科医生都将高质量的患者护理放在首位,但在其他首要任务方面却有所不同。外科医生最常提到的福利威胁是手术室效率低下/延误和工作量过大,而麻醉医生则提到人手不足和工作时间不可预测:结论:外科医生和麻醉师有许多共同的需求和优先事项,其痛点往往具有负面协同作用。将 QOLI 方法应用于各专科,可以进行福利干预,尊重复杂性并促进制定可行的解决方案。
{"title":"Looking Across the Drape: A Novel Quality Improvement Approach to Understanding Surgeon and Anesthesiologist Burnout.","authors":"Jina L Sinskey, Rachel Schwartz, Christy K Boscardin, Joyce M Chang, Sandhya B Kumar, Carter C Lebares","doi":"10.1097/SLA.0000000000006241","DOIUrl":"10.1097/SLA.0000000000006241","url":null,"abstract":"<p><strong>Objective: </strong>To identify well-being threats for surgeons and anesthesiologists and develop interventions using the quality of life improvement (QOLI) approach.</p><p><strong>Background: </strong>Developing feasible perioperative well-being interventions requires identifying shared and specialty-specific well-being needs. The QOLI framework integrates human-centered design, implementation science, and quality improvement to address well-being needs.</p><p><strong>Methods: </strong>Anesthesia and surgery faculty in 8 perioperative departments at an academic medical center completed cross-sectional surveys containing validated measures of well-being and workplace satisfaction, and open-ended questions about professional motivations, pain points, strategies for improvement, and well-being priorities. Using template analysis, we analyzed open-ended survey data and presented resulting themes at a joint-specialty town hall for live voting to identify well-being priorities.</p><p><strong>Results: </strong>One hundred four perioperative faculty completed the survey. Across specialties, higher Mental Health Continuum-Short Form scores (representative of individual global well-being) were associated with higher satisfaction with workplace control, values, decision latitude, and social support. Anesthesiologists reported lower satisfaction and control than surgeons across multiple domains. Template analysis yielded 5 areas for intervention: (1) work culture, (2) work environment/resources, (3) sources of fulfillment, (4) work/life harmony, and (5) financial compensation. Surgeons and anesthesiologists both prioritized high-quality patient care but differed in their other top priorities. The most frequently cited well-being threats for surgeons were operating room inefficiencies/delays and excessive workload, whereas anesthesiologists cited understaffing and unpredictable work hours.</p><p><strong>Conclusions: </strong>Surgeons and anesthesiologists share many needs and priorities, with pain points that are often negatively synergistic. Applying the QOLI approach across specialties allows for well-being interventions that honor complexity and promote the development of feasible solutions.</p>","PeriodicalId":8017,"journal":{"name":"Annals of surgery","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139904858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethical Considerations for Resource Allocation Towards Sustainable Surgery. 实现可持续外科手术的资源分配的伦理考虑因素。
IF 7.5 1区 医学 Q1 SURGERY Pub Date : 2024-12-01 Epub Date: 2024-05-06 DOI: 10.1097/SLA.0000000000006325
David Blitzer, Robert M Sade, Brandi Scully
{"title":"Ethical Considerations for Resource Allocation Towards Sustainable Surgery.","authors":"David Blitzer, Robert M Sade, Brandi Scully","doi":"10.1097/SLA.0000000000006325","DOIUrl":"10.1097/SLA.0000000000006325","url":null,"abstract":"","PeriodicalId":8017,"journal":{"name":"Annals of surgery","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Annals of surgery
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