Pub Date : 2024-02-21DOI: 10.1007/s11244-024-01911-1
Abstract
Enzymes are essential biological catalysts that can accelerate multiple reactions. Their outstanding catalytic properties make them highly valuable in different research fields and industries including pharmaceutical, sensing, food, and agriculture. However, the catalytic attributes of free enzymes are limited by their poor stability and resistance to harsh conditions. Recently, the conjugation of different enzymes with carbon dots (CDs) has been explored as a novel strategy for tuning their catalytic properties. CDs possess unique and tunable characteristics such as light stability, electron transfer properties, lower toxicity, cost-efficiency, and outstanding biocompatibility; thus, they represent excellent options for the conjugation of different enzymes to improve their stability, selectivity, and catalytic efficiency. Recently, various CDs-based nano-biocatalysts have been successfully prepared with superior performances compared to their free enzymes. Therefore, this review aims to discuss the most recent reported studies in the synthesis of CDs-based nano-biocatalysts providing an overview of current methodologies and recent research applications. Lastly, we delve into the prospects and the future possibilities of such innovative conjugates that entail an exploration of the faced challenges and their untapped potential for various applications.
Graphical Abstract
摘要 酶是一种重要的生物催化剂,可以加速多种反应。酶的卓越催化特性使其在制药、传感、食品和农业等不同研究领域和行业中具有极高的价值。然而,游离酶的催化特性因其稳定性差和对恶劣条件的耐受性而受到限制。最近,人们探索了将不同的酶与碳点(CD)共轭,作为调整其催化特性的一种新策略。碳点具有独特的可调特性,如光稳定性、电子传递特性、低毒性、成本效益和出色的生物相容性;因此,它们是缀合不同酶以提高其稳定性、选择性和催化效率的绝佳选择。最近,人们成功制备了各种基于 CD 的纳米生物催化剂,其性能优于游离酶。因此,本综述旨在讨论有关合成 CD 基纳米生物催化剂的最新研究报告,概述当前的方法和最新的研究应用。最后,我们将深入探讨此类创新型共轭物的前景和未来可能性,包括所面临的挑战及其在各种应用中尚未开发的潜力。 图表摘要
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Pub Date : 2024-02-20DOI: 10.1007/s11244-024-01904-0
Muhammad Ali Yousif Al Janabi, Rima Nour El Houda Tiri, Ali Cherif, Elif Esra Altuner, Chul-Jin Lee, Fatih Sen, Elena Niculina Dragoi, Fatemeh Karimi, Shankramma Kalikeri
In this work, CuFe2O4 nanoparticles (NPs) were created using a hydrothermal process. The form and size of the obtained CuFe2O4 NPs were characterized using XRD and TEM techniques. The Scherrer equation and XRD measurements revealed that the crystal size of nanoparticles was 10.79 nm. The TEM study of nanoparticles with an average size of 7.673.75 nm revealed a distinctive core–shell structure. The methanolysis on NaBH4 at various parameters was used to assess the catalytic activity of NPs. The results showed that CuFe2O4 NPs are an effective catalyst for the methanolysis of NaBH4 in alkaline solutions, as demonstrated by the activation energy of 33.31 kJ/mol and turnover frequency (TOF), which was estimated as 2774.61 min−1 under ambient circumstances. These obtained NPs also showed an excellent (92%) reusability. A deep neural network architecture was determined using a neuro-evolutive approach based on a genetic algorithm to model the process and predict the catalyst performance in changing operating conditions. The determined models had a correlation > 0.9 and a mean squared error in the testing phase < 7.5%, indicating their capacity to capture the process dynamic effectively.
{"title":"Hydrogen Generation by Methanolysis of NaBH4 via Efficient CuFe2O4 Nanoparticle Catalyst: A Kinetic Study and DNN Model","authors":"Muhammad Ali Yousif Al Janabi, Rima Nour El Houda Tiri, Ali Cherif, Elif Esra Altuner, Chul-Jin Lee, Fatih Sen, Elena Niculina Dragoi, Fatemeh Karimi, Shankramma Kalikeri","doi":"10.1007/s11244-024-01904-0","DOIUrl":"https://doi.org/10.1007/s11244-024-01904-0","url":null,"abstract":"<p>In this work, CuFe<sub>2</sub>O<sub>4</sub> nanoparticles (NPs) were created using a hydrothermal process. The form and size of the obtained CuFe<sub>2</sub>O<sub>4</sub> NPs were characterized using XRD and TEM techniques. The Scherrer equation and XRD measurements revealed that the crystal size of nanoparticles was 10.79 nm. The TEM study of nanoparticles with an average size of 7.673.75 nm revealed a distinctive core–shell structure. The methanolysis on NaBH<sub>4</sub> at various parameters was used to assess the catalytic activity of NPs. The results showed that CuFe<sub>2</sub>O<sub>4</sub> NPs are an effective catalyst for the methanolysis of NaBH<sub>4</sub> in alkaline solutions, as demonstrated by the activation energy of 33.31 kJ/mol and turnover frequency (TOF), which was estimated as 2774.61 min<sup>−1</sup> under ambient circumstances. These obtained NPs also showed an excellent (92%) reusability. A deep neural network architecture was determined using a neuro-evolutive approach based on a genetic algorithm to model the process and predict the catalyst performance in changing operating conditions. The determined models had a correlation > 0.9 and a mean squared error in the testing phase < 7.5%, indicating their capacity to capture the process dynamic effectively.</p>","PeriodicalId":801,"journal":{"name":"Topics in Catalysis","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139922138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-20DOI: 10.1007/s11244-024-01910-2
Iqra Batool, Ayesha Anwar, Muhammad Imran, Zara Idress Alvi
Nanozymes (NZs), or nanostructures exhibiting enzyme mimicking exertion, have drawn a lot of attention recently owing to their ability to substitute enzymes that are naturally occurring in an array of bio-medical applications, notably biological detection, therapeutics, pharmaceutical administration, as well as biological imaging. In comparison to single enzymatic NZs, multi-enzymatic NZs have additional benefits, especially improved selectivity, a more favorable ecological impact, and synergistic effects. In contrast, the catalytic mechanism and rational design of multi-enzymatic NZs are more complex than those of single enzymatic NZs, which have simple catalytic mechanisms. NZs that can regulate cellular redox equilibrium by emulating the antioxidant enzymes in cells are particularly crucial towards alleviating ailments induced on by cellular oxidative stress. Carbonaceous materials i.e. graphene, fullerenes, quantum dots, carbon nano-sheets, nano-rods, MOFs etc. demonstrated peroxidase (POD), oxidase (OXD), superoxide dismutase (SOD), and catalase (CAT)-like functioning in a range of domains on the basis of oxidation mitigation mechanisms employing electron transport channels. Furthermore, integrating a couple of hetero-atoms to carbon-based materials enhanced their efficacy in various industries. NZs derived from bioactive materials demonstrate catalytic properties similar to those of enzymes. Bioactive material-based NZs are essential because of their unique catalytic properties, which surpass the efficiency, selectivity, and flexibility of traditional catalysts moreover, offering a cost-effective and environmentally friendly alternative to conventional precursors in catalysis. Their surfaces can be precisely modified, opening up new possibilities for selective and green synthetic techniques. Bioactive materials-based NZs have exceptional biological activity and compatibility in the field of medicine, thus rendering them useful instruments for both diagnosis and therapy. Due to their innate capacity to imitate the catalytic functions of natural enzymes, they can be utilized to develop intricate bio-sensors, precise drug delivery systems, and extremely sensitive diagnostic platforms. Moreover, low cytotoxicity of these materials facilitates the easier integration of chemicals into biological systems. This review provided an overview of the multi-enzymatic activities of rationally designed carbon-based NMs, both the internal and external variables that regulate the multi-enzymatic enzymes endeavours, and current advancements in application areas which benefit from multi-enzymatic distinctive characteristics. Prospective uses and development of multi-enzymatic carbon-based NZs might confront multiple challenges. This review aims to stimulate and improve our understanding of multi-enzymatic carbon-based processes to a greater extent.