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A case report of labyrinthine infarction: a 'central' cause of vertigo with 'peripheral' presentation. 迷宫梗塞病例报告:眩晕的 "中心 "病因与 "外周 "表现。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-24 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002579
Khadija El Bouhmadi, Safa Darouich, Myriam Youbi, Said Anajar, Mustapha Essaadi, Khalid Snoussi, Amal Hajjij

Introduction and importance: The inner ear is considered an 'end organ' since its vascular supply comes from one terminal artery, making the labyrinth especially vulnerable to ischemia, causing loss of auditory and vestibular function with variable clinical patterns according to the different arterial distribution in the inner ear and which vascular branches are concerned by the embolism.

Case presentation: We report a misleading case of central vascular vertigo caused by a labyrinthine infarction resulting from an embolic vertebral artery, which manifested in a typical peripheral clinical presentation mimicking a vestibular neuritis.

Clinical discussion: Vertigo is the result of asymmetrical responses from the vestibules of both ears resulting from any disruption along the complex vestibular pathways, whether peripheral or central. The recognition of the origin of an acute isolated vertigo is fundamental since the therapeutic strategy and prognosis differ, but it can be challenging in the absence of neurological signs, especially when the clinical pattern involves only the vestibular part of the labyrinth.

Conclusion: The diagnosis strategy should consider the patient vascular risk factors and the clinical bedside tests with diffusion-weighted magnetic resonance imaging (MRI). Then, the management of these patients requires pluridisciplinary cooperation with early vestibular rehabilitation.

导言和重要性:内耳被认为是一个 "终末器官",因为它的血管供应来自一条终末动脉,这使得迷宫特别容易缺血,导致听觉和前庭功能丧失,根据内耳动脉分布的不同以及栓塞涉及的血管分支,临床表现也各不相同:我们报告了一例由椎动脉栓塞导致的迷宫梗塞引起的中枢性血管性眩晕的误导性病例,该病例表现为模仿前庭神经炎的典型外周临床表现:眩晕是由于复杂的前庭通路(无论是外周的还是中枢的)受到任何干扰而导致双耳前庭反应不对称的结果。由于治疗策略和预后不同,因此识别急性孤立性眩晕的起源至关重要,但在没有神经系统体征的情况下,尤其是当临床模式仅涉及迷宫的前庭部分时,识别眩晕的起源可能具有挑战性:诊断策略应考虑患者的血管风险因素以及临床床旁检查和弥散加权磁共振成像(MRI)。结论:诊断策略应考虑患者的血管风险因素和弥散加权磁共振成像(MRI)的临床床旁检查,然后,对这些患者的治疗需要多学科合作,早期进行前庭康复治疗。
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引用次数: 0
Surgical resection of a rare scalp arteriovenous malformation: a case report. 罕见头皮动静脉畸形的手术切除:病例报告。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-24 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002596
Khitamul Haq, Muhammad A Waqas, Saleem Akhter, Juan J Cardona, Gianluca Scalia, Giuseppe E Umana, Bipin Chaurasia

Introduction and importance: Scalp arteriovenous malformations (AVMs) are intricate vascular anomalies with abnormal connections between arteries and veins in the scalp, leading to serious complications and cosmetic concerns. Managing scalp AVMs is particularly complex in young female patients, where both functional and aesthetic outcomes are crucial. This case report highlights the successful treatment of a young woman with a scalp AVM, emphasizing the importance of early diagnosis and a multidisciplinary approach.

Case presentation: A 30-year-old female presented with a pulsatile scalp mass and significant cosmetic concerns. Diagnostic imaging, including ultrasonography, brain CT scan, MRI, and carotid CT angiogram, confirmed a scalp AVM. The patient underwent a comprehensive treatment plan beginning with endovascular embolization to reduce blood flow to the AVM, followed by surgical resection to remove the lesion. Postoperative follow-up showed a marked reduction in symptoms and lesion volume, with no complications observed.

Clinical discussion: Scalp AVMs, though rare, require prompt diagnosis due to the risk of severe complications such as hemorrhage and cosmetic impact. In this case, a combination of ultrasonography, CT, and MRI provided a detailed assessment of the AVM. A multidisciplinary approach, involving interventional radiology and surgical expertise, was crucial for success. Endovascular embolization minimized intraoperative bleeding and simplified surgical resection, leading to significant symptom and cosmetic improvements. Continuous monitoring is essential for long-term success and early detection of recurrences.

Conclusion: This case underscores the effectiveness of a multidisciplinary approach in managing scalp AVMs in young female patients. Early diagnosis through advanced imaging techniques enables timely and targeted intervention. The combined use of endovascular embolization and surgical resection led to significant symptom resolution and aesthetic enhancement. Collaboration among specialists is vital for optimizing outcomes, and ongoing research will further refine treatment strategies, improving the quality of life for patients with scalp AVMs.

导言和重要性:头皮动静脉畸形(AVM)是头皮动脉和静脉之间异常连接的复杂血管异常,会导致严重的并发症和美容问题。对于年轻女性患者来说,头皮动静脉畸形的治疗尤为复杂,其功能和美观效果都至关重要。本病例报告重点介绍了一名年轻女性头皮动静脉畸形患者的成功治疗,强调了早期诊断和多学科治疗的重要性:一名 30 岁的女性因头皮搏动性肿块和严重的外观问题前来就诊。超声波检查、脑部 CT 扫描、核磁共振成像和颈动脉 CT 血管造影等诊断性影像学检查证实患者患有头皮动静脉畸形。患者接受了综合治疗方案,首先进行血管内栓塞以减少动静脉畸形的血流量,然后进行手术切除以清除病灶。术后随访显示,患者的症状和病变体积明显减轻,未发现并发症:临床讨论:头皮动静脉畸形虽然罕见,但由于存在严重并发症(如出血和影响美观)的风险,因此需要及时诊断。在该病例中,超声波、CT 和核磁共振成像相结合,对 AVM 进行了详细评估。介入放射学和外科专家参与的多学科方法是成功的关键。血管内栓塞术最大限度地减少了术中出血,简化了手术切除,从而显著改善了症状和外观。持续监测对长期成功和早期发现复发至关重要:本病例强调了采用多学科方法治疗年轻女性头皮动静脉畸形的有效性。通过先进的成像技术进行早期诊断可实现及时和有针对性的干预。联合使用血管内栓塞术和手术切除术后,症状得到明显缓解,美观度也有所提高。专科医生之间的合作对于优化治疗效果至关重要,正在进行的研究将进一步完善治疗策略,提高头皮动静脉畸形患者的生活质量。
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引用次数: 0
Leveraging telemedicine for enhanced maternal and perinatal care in rural Nepal: opportunities and challenges. 利用远程医疗加强尼泊尔农村地区的孕产妇和围产期保健:机遇与挑战。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-23 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002588
Pratik Adhikari

This article explores the potential of telemedicine to revolutionize maternal and perinatal healthcare delivery in rural Nepal, where access to medical facilities is limited. By utilizing telemedicine technologies like remote consultations, mobile health applications, and tele-ultrasound, the authors can overcome barriers to healthcare access and improve outcomes for expectant mothers and newborns. The paper assesses the opportunities presented by telemedicine interventions and addresses the challenges that must be addressed for successful integration into rural healthcare systems.

本文探讨了远程医疗在彻底改变尼泊尔农村地区孕产妇和围产期保健服务方面的潜力。通过利用远程会诊、移动医疗应用程序和远程超声波等远程医疗技术,作者可以克服获得医疗服务的障碍,改善孕妇和新生儿的治疗效果。本文评估了远程医疗干预措施带来的机遇,并探讨了成功融入农村医疗系统必须应对的挑战。
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引用次数: 0
Integrated psychiatric and surgical care in managing self-inflicted abdominal trauma: a case report in a resource-limited setting. 在处理自残性腹部外伤过程中的精神科和外科综合护理:资源有限环境中的病例报告。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-23 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002593
Pratik Adhikari

Introduction and importance: Self-inflicted abdominal stab wounds present rare yet critical challenges requiring urgent surgical intervention and comprehensive psychiatric evaluation. Such injuries often correlate with psychiatric disorders like schizophrenia and alcohol dependence, posing significant clinical and psychological management hurdles.

Case presentation: A 36-year-old male with a history of chronic alcohol use and schizophrenia presented with a self-inflicted stab wound to the abdomen following auditory hallucinations. Upon admission, he was hemodynamically unstable, with eviscerated bowel loops and a lacerated greater omentum. Prompt surgical exploration revealed extensive abdominal trauma necessitating meticulous repair and intensive postoperative care.

Clinical discussion: The case highlights the intricate interplay between severe psychiatric illness and self-harm, exacerbated by alcohol intoxication. Integrated psychiatric and surgical care proved pivotal in achieving stabilization and facilitating recovery. The challenges encountered in a resource-limited setting included a lack of advanced imaging modalities, limited access to specialized psychiatric care, and constraints in postoperative monitoring equipment, underscoring the importance of adaptive management strategies.

Conclusion: This report emphasizes the critical need for a multidisciplinary approach in managing self-inflicted abdominal injuries. The successful outcome underscores the efficacy of timely surgical intervention and comprehensive psychiatric support. Integrated care models are essential for addressing the complex needs of patients with psychiatric comorbidities, ensuring holistic management, and reducing the risk of recurrence in similar cases.

导言和重要性:腹部自伤是一种罕见但严峻的挑战,需要紧急手术干预和全面的精神评估。此类伤害往往与精神分裂症和酒精依赖等精神疾病有关,给临床和心理治疗带来了巨大障碍:病例介绍:一名 36 岁男性,有长期酗酒和精神分裂症病史,因幻听自伤腹部。入院时,他的血流动力学不稳定,肠套叠撕裂,大网膜撕裂。及时的手术探查显示他的腹部有大面积创伤,需要进行精心修补和术后强化护理:临床讨论:该病例凸显了严重精神疾病与自我伤害之间错综复杂的相互作用,酒精中毒又加剧了这种相互作用。事实证明,精神科和外科的综合护理在实现病情稳定和促进康复方面发挥了关键作用。在资源有限的环境中遇到的挑战包括缺乏先进的成像模式、获得专业精神科护理的机会有限以及术后监测设备的限制,这凸显了适应性管理策略的重要性:本报告强调了采用多学科方法处理自伤性腹部损伤的重要性。成功的结果凸显了及时手术干预和全面精神支持的功效。综合护理模式对于满足合并精神疾病患者的复杂需求、确保整体管理以及降低类似病例的复发风险至关重要。
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引用次数: 0
Early removal of transorbital penetrating traumatic brain injury by a wooden object: a case report. 木质物体造成的经眶穿透性脑外伤的早期切除:病例报告。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-20 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002584
Parbatraj Regmi, Alok Dahal, Samiksha Bhattrai, Shambhu Nandan Khadga, Sagar Mani Regmi, Aliza Paudyal

Introduction and importance: Transorbital penetrating traumatic brain injury (TPTBI) is a rare cause of penetrating head injury, yet the diagnoses can be overlooked in some cases due to incomplete history, trivial trauma, and the absence of immediate neurologic deficits.

Case presentation: A 4-year-old male child was admitted with a diagnosis of TPTBI by a wooden object. Noncontrast enhanced CT scan revealed a linear hypodense structure extending from the superior wall of the right orbit into the frontal lobe with displaced fragments into the brain. Additionally, cerebral contusion, pneumocephalus, and hematoma with surrounding edema were seen in the frontal lobe. Early extraction of the foreign body was performed by a multidisciplinary team of neurosurgeons and ophthalmologists. The wooden fragment of size 10 cm×1 cm×1 cm was removed by a small mini-craniotomy of the right frontal supraorbital bone with the gentle pulling of it through the dura mater and frontal cortex. The postoperative course was uncomplicated, vision was restored, and there were no neurologic deficits at the time of discharge on the seventh postoperative day with good postoperative outcomes.

Clinical discussion: Delayed removal of TPTBI may be complicated by misidentification of entry points, extensive scarring around the foreign body, adherence to the intracranial vessels, and increasing mortality due to infectious complications. Therefore, early exploration with the help of a multidisciplinary team will most likely result in successful debridement, good neurologic outcomes, and lower morbidity and mortality.

Conclusion: Accurate diagnosis and early intervention for TPTBI may prevent possible infectious and neurologic complications.

导言和重要性:眶外穿透性创伤性脑损伤(TPTBI)是一种罕见的头部穿透性损伤,但由于病史不完整、外伤轻微、无直接神经功能缺损等原因,有些病例的诊断可能会被忽视:一名 4 岁男童入院时被诊断为木质物体造成的 TPTBI。非对比增强 CT 扫描显示,一个线状低密度结构从右眼眶上壁延伸至额叶,碎片移位至大脑。此外,额叶还出现了脑挫伤、气胸和血肿及周围水肿。由神经外科医生和眼科医生组成的多学科团队及早取出了异物。通过在右额骨眶上部进行小型开颅手术,将 10 厘米×1 厘米×1 厘米大小的木质碎片取出,并通过硬脑膜和额叶皮层将其轻轻拉出。术后过程并不复杂,视力恢复良好,术后第七天出院时无神经功能障碍,术后效果良好:临床讨论:延迟取出 TPTBI 可能会因误认为异物入口、异物周围广泛瘢痕、异物与颅内血管粘连以及感染并发症导致死亡率升高而变得复杂。因此,在多学科团队的帮助下尽早进行探查,很可能会成功清创,获得良好的神经功能结果,并降低发病率和死亡率:结论:TPTBI 的准确诊断和早期干预可预防可能出现的感染和神经系统并发症。
{"title":"Early removal of transorbital penetrating traumatic brain injury by a wooden object: a case report.","authors":"Parbatraj Regmi, Alok Dahal, Samiksha Bhattrai, Shambhu Nandan Khadga, Sagar Mani Regmi, Aliza Paudyal","doi":"10.1097/MS9.0000000000002584","DOIUrl":"https://doi.org/10.1097/MS9.0000000000002584","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Transorbital penetrating traumatic brain injury (TPTBI) is a rare cause of penetrating head injury, yet the diagnoses can be overlooked in some cases due to incomplete history, trivial trauma, and the absence of immediate neurologic deficits.</p><p><strong>Case presentation: </strong>A 4-year-old male child was admitted with a diagnosis of TPTBI by a wooden object. Noncontrast enhanced CT scan revealed a linear hypodense structure extending from the superior wall of the right orbit into the frontal lobe with displaced fragments into the brain. Additionally, cerebral contusion, pneumocephalus, and hematoma with surrounding edema were seen in the frontal lobe. Early extraction of the foreign body was performed by a multidisciplinary team of neurosurgeons and ophthalmologists. The wooden fragment of size 10 cm×1 cm×1 cm was removed by a small mini-craniotomy of the right frontal supraorbital bone with the gentle pulling of it through the dura mater and frontal cortex. The postoperative course was uncomplicated, vision was restored, and there were no neurologic deficits at the time of discharge on the seventh postoperative day with good postoperative outcomes.</p><p><strong>Clinical discussion: </strong>Delayed removal of TPTBI may be complicated by misidentification of entry points, extensive scarring around the foreign body, adherence to the intracranial vessels, and increasing mortality due to infectious complications. Therefore, early exploration with the help of a multidisciplinary team will most likely result in successful debridement, good neurologic outcomes, and lower morbidity and mortality.</p><p><strong>Conclusion: </strong>Accurate diagnosis and early intervention for TPTBI may prevent possible infectious and neurologic complications.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"86 11","pages":"6794-6797"},"PeriodicalIF":1.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergency esophagectomy for esophageal perforation following balloon dilation due to stenosis post-endoscopic submucosal dissection for esophageal cancer: a case report. 内镜粘膜下剥离术治疗食管癌后因狭窄导致球囊扩张后食管穿孔的紧急食管切除术:病例报告。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-20 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002573
Binh Van Pham, Duy Duc Nguyen, Manh Dai Tran, Thanh Duy Nguyen, An Duc Thai, Hoa Thi Thanh Nguyen

Introduction and importance: Esophageal perforation from endoscopic dilation is rare (0.53-0.6% incidence) but serious, with mortality rates of 12.5-20%. Optimal treatment is debated and depends on the medical facility's capabilities, the patient's symptoms, the extent of perforation, and the severity of associated lesions. Treatment options include medical management (fasting, antibiotics), esophageal stenting, surgical closure, or emergency esophagectomy. Early diagnosis and treatment are crucial to reduce mortality and hospital stay.

Case presentation: A 49-year-old male with lower third esophageal cancer (stage cT1aN0M0) underwent endoscopic submucosal dissection (ESD) and developed esophageal stenosis. Dilation attempts led to esophageal perforation, necessitating emergency esophagectomy with gastric conduit reconstruction. The patient improved and was discharged on day 10 post-operation without complications.

Clinical discussion: Managing esophageal perforation post-endoscopic dilation is complex. This case highlights the importance of rapid recognition and intervention. Esophageal dilation, while effective for stenosis, carries a perforation risk. Treatment decisions must be tailored to individual patients, considering perforation severity, patient's health, and facility resources. Here, severe perforation and clinical condition warranted emergency esophagectomy. The successful outcome underscores the efficacy of this surgical intervention when performed timely at specialized centers.

Conclusion: Emergency esophagectomy with gastric conduit reconstruction for treating esophageal perforation due to stenosis post-endoscopic submucosal dissection for esophageal cancer is considered a safe procedure and can be performed at an experienced esophageal surgery center.

导言和重要性:内窥镜扩张术造成的食管穿孔非常罕见(发生率为 0.53-0.6%),但情况严重,死亡率高达 12.5-20%。最佳治疗方法尚存争议,取决于医疗机构的能力、患者的症状、穿孔范围以及相关病变的严重程度。治疗方案包括药物治疗(禁食、抗生素)、食管支架植入术、手术缝合或急诊食管切除术。早期诊断和治疗对降低死亡率和缩短住院时间至关重要:病例介绍:一名 49 岁男性,患有下第三段食管癌(cT1aN0M0 期),接受了内镜粘膜下剥离术(ESD),并出现食管狭窄。扩张尝试导致食管穿孔,因此必须进行紧急食管切除术,并进行胃导管重建。患者病情好转,术后第 10 天出院,未出现并发症:临床讨论:内镜扩张术后食管穿孔的处理非常复杂。本病例强调了快速识别和干预的重要性。食管扩张术虽然对狭窄有效,但也存在穿孔风险。必须考虑穿孔的严重程度、患者的健康状况和医疗机构的资源,根据患者的具体情况做出治疗决定。在这里,严重的穿孔和临床状况需要进行紧急食管切除术。成功的结果强调了在专业中心及时进行这种手术干预的有效性:结论:内镜粘膜下剥离术治疗食管癌后因狭窄导致的食管穿孔时,可在经验丰富的食管外科中心实施紧急食管切除术并重建胃导管。
{"title":"Emergency esophagectomy for esophageal perforation following balloon dilation due to stenosis post-endoscopic submucosal dissection for esophageal cancer: a case report.","authors":"Binh Van Pham, Duy Duc Nguyen, Manh Dai Tran, Thanh Duy Nguyen, An Duc Thai, Hoa Thi Thanh Nguyen","doi":"10.1097/MS9.0000000000002573","DOIUrl":"https://doi.org/10.1097/MS9.0000000000002573","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Esophageal perforation from endoscopic dilation is rare (0.53-0.6% incidence) but serious, with mortality rates of 12.5-20%. Optimal treatment is debated and depends on the medical facility's capabilities, the patient's symptoms, the extent of perforation, and the severity of associated lesions. Treatment options include medical management (fasting, antibiotics), esophageal stenting, surgical closure, or emergency esophagectomy. Early diagnosis and treatment are crucial to reduce mortality and hospital stay.</p><p><strong>Case presentation: </strong>A 49-year-old male with lower third esophageal cancer (stage cT1aN0M0) underwent endoscopic submucosal dissection (ESD) and developed esophageal stenosis. Dilation attempts led to esophageal perforation, necessitating emergency esophagectomy with gastric conduit reconstruction. The patient improved and was discharged on day 10 post-operation without complications.</p><p><strong>Clinical discussion: </strong>Managing esophageal perforation post-endoscopic dilation is complex. This case highlights the importance of rapid recognition and intervention. Esophageal dilation, while effective for stenosis, carries a perforation risk. Treatment decisions must be tailored to individual patients, considering perforation severity, patient's health, and facility resources. Here, severe perforation and clinical condition warranted emergency esophagectomy. The successful outcome underscores the efficacy of this surgical intervention when performed timely at specialized centers.</p><p><strong>Conclusion: </strong>Emergency esophagectomy with gastric conduit reconstruction for treating esophageal perforation due to stenosis post-endoscopic submucosal dissection for esophageal cancer is considered a safe procedure and can be performed at an experienced esophageal surgery center.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"86 11","pages":"6766-6771"},"PeriodicalIF":1.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nogapendekin alfa inbakicept-PMLN: first approval milestone for BCG-unresponsive noninvasive bladder cancer: editorial. Nogapendekin alfa inbakicept-PMLN:卡介苗无反应非浸润性膀胱癌首次获批的里程碑:社论。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-20 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002591
Aiman Waheed, Muhammad H Gul, Abdul B Wardak, Hafsa A A Raja, Helai Hussaini
{"title":"Nogapendekin alfa inbakicept-PMLN: first approval milestone for BCG-unresponsive noninvasive bladder cancer: editorial.","authors":"Aiman Waheed, Muhammad H Gul, Abdul B Wardak, Hafsa A A Raja, Helai Hussaini","doi":"10.1097/MS9.0000000000002591","DOIUrl":"https://doi.org/10.1097/MS9.0000000000002591","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"86 11","pages":"6386-6388"},"PeriodicalIF":1.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging public health strategies in malaria control: innovations and implications. 控制疟疾的新兴公共卫生战略:创新与影响。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-20 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002578
Emmanuel Ifeanyi Obeagu, Getrude Uzoma Obeagu

Malaria remains a significant global health challenge, particularly in regions with limited resources and tropical climates. Despite extensive efforts, the disease continues to cause significant morbidity and mortality, with ~229 million cases and 409 000 deaths reported in 2020. However, recent years have seen promising advancements in public health strategies aimed at malaria control and elimination. Technological advancements have played a crucial role in improving malaria control efforts. Genomic surveillance techniques enable the monitoring of malaria parasite populations, aiding in the detection of drug resistance and informing targeted interventions. Additionally, innovative diagnostic technologies, such as rapid diagnostic tests (RDTs) and molecular assays, have enhanced the speed and accuracy of malaria diagnosis, facilitated prompt treatment and reduced transmission. These tools are instrumental in achieving the WHO goals of reducing malaria cases and deaths by at least 90% by 2030. Novel vector control methods offer innovative approaches to reduce malaria transmission. Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) remain foundational strategies, with advancements including the development of next-generation insecticides and long-lasting insecticidal nets (LLINs). Furthermore, genetic modification of mosquitoes, such as gene drive technology, holds promise for reducing mosquito populations and interrupting malaria transmission. These vector control innovations complement other strategies, contributing to comprehensive malaria control efforts aimed at achieving sustainable disease reduction and eventual elimination.

疟疾仍然是全球健康的重大挑战,尤其是在资源有限和热带气候的地区。尽管做出了广泛的努力,但疟疾仍然造成了严重的发病率和死亡率,据报告,2020 年将有约 2.29 亿病例和 40.9 万人死亡。然而,近年来,旨在控制和消除疟疾的公共卫生战略取得了可喜的进展。技术进步在改善疟疾控制工作方面发挥了至关重要的作用。基因组监测技术能够监测疟原虫种群,帮助检测抗药性并为有针对性的干预措施提供信息。此外,快速诊断检测(RDTs)和分子检测等创新诊断技术提高了疟疾诊断的速度和准确性,促进了及时治疗并减少了传播。这些工具有助于实现世卫组织到 2030 年将疟疾病例和死亡人数至少减少 90% 的目标。新型病媒控制方法为减少疟疾传播提供了创新方法。驱虫蚊帐(ITNs)和室内滞留喷洒(IRS)仍然是基础战略,其进展包括开发下一代杀虫剂和长效驱虫蚊帐(LLINs)。此外,基因改造蚊子(如基因驱动技术)也为减少蚊子数量和阻断疟疾传播带来了希望。这些病媒控制创新是对其他战略的补充,有助于全面控制疟疾,以实现可持续减少疾病和最终消灭疟疾的目标。
{"title":"Emerging public health strategies in malaria control: innovations and implications.","authors":"Emmanuel Ifeanyi Obeagu, Getrude Uzoma Obeagu","doi":"10.1097/MS9.0000000000002578","DOIUrl":"https://doi.org/10.1097/MS9.0000000000002578","url":null,"abstract":"<p><p>Malaria remains a significant global health challenge, particularly in regions with limited resources and tropical climates. Despite extensive efforts, the disease continues to cause significant morbidity and mortality, with ~229 million cases and 409 000 deaths reported in 2020. However, recent years have seen promising advancements in public health strategies aimed at malaria control and elimination. Technological advancements have played a crucial role in improving malaria control efforts. Genomic surveillance techniques enable the monitoring of malaria parasite populations, aiding in the detection of drug resistance and informing targeted interventions. Additionally, innovative diagnostic technologies, such as rapid diagnostic tests (RDTs) and molecular assays, have enhanced the speed and accuracy of malaria diagnosis, facilitated prompt treatment and reduced transmission. These tools are instrumental in achieving the WHO goals of reducing malaria cases and deaths by at least 90% by 2030. Novel vector control methods offer innovative approaches to reduce malaria transmission. Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) remain foundational strategies, with advancements including the development of next-generation insecticides and long-lasting insecticidal nets (LLINs). Furthermore, genetic modification of mosquitoes, such as gene drive technology, holds promise for reducing mosquito populations and interrupting malaria transmission. These vector control innovations complement other strategies, contributing to comprehensive malaria control efforts aimed at achieving sustainable disease reduction and eventual elimination.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"86 11","pages":"6576-6584"},"PeriodicalIF":1.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of velopharyngeal insufficiency by a new modification of sphincter pharyngoplasty technique in cleft palate patients, clinical and radiographical prospective study. 通过腭裂患者括约肌咽成形术新改良技术治疗腭咽闭合不全的临床和放射学前瞻性研究。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-19 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002582
Jafar Hamdy, Hikmat Yacoub

Background: This study was designed to investigate the effectiveness and outcome of a new modification of the sphincter pharyngoplasty technique in the treatment of velopharyngeal insufficiency patients, with the determination of a specific dimension of velopharyngeal port and velum length of no hypernasality, snoring, and nasal regurgitation potential.

Materials and methods: The study included 10 patients, who were suffering from consistent hypernasal speech after failure of conservative speech therapy. Clinical and radiographic measurements of the velopharyngeal port and velum length before and after surgery were done, with clinical patient follow-up to assess snoring and nasal regurgitation after surgery for 1, 6, and 12 months.

Results: Before surgery, the mean clinical anteroposterior distance/velopharyngeal depth was 16.40±1.7 mm, and the mediolateral distance was 20.20±3.4 mm. After surgery, the mean anteroposterior distance decreased to 8±0.9 mm, and the mean mediolateral distance decreased to 12.60±2.06 mm. Both measurements showed statistically significant (P=0.0001). After 12 months postoperatively, the radiographic CT axial anteroposterior distance was 12.09±1.4 mm, and the mean mediolateral distance was 19.82±5.6 mm, compared to the mean CT anterioposterior before surgery 15.60±2 mm and mediolaterally 21.28±2.7 mm. The anteroposterior measurement showed a statistically significant (P=0.002), while the mediolateral measurement did not (P=0.3). The mean velum length before surgery was 25.80±1.5 mm and 27.03±0.6 mm after 12 months postoperatively. Snoring and nasal regurgitation occurrence were assessed at 1, 6, and 12 months postoperatively, with all reports being negative.

Conclusion: Sphincter pharyngoplasty using posterior tonsillar pillars for treating VPI patients results in improved speech outcomes without snoring or nasal regurgitation.

研究背景本研究旨在探讨括约肌咽成形术的新改良技术在治疗咽喉功能不全患者中的有效性和结果,并确定咽喉口和咽鼓管长度的特定尺寸,以避免出现高鼻音、打鼾和鼻反流的可能性:研究对象包括 10 名患者,他们在保守言语治疗失败后出现持续的高鼻音。对手术前后的咽口和伶牙长度进行临床和影像学测量,并在术后1、6和12个月对患者进行临床随访,以评估打鼾和鼻反流情况:手术前,平均临床前胸距/咽喉深度为 16.40±1.7 mm,内外侧距为 20.20±3.4 mm。手术后,平均前胸距降至 8±0.9 mm,平均内外侧距降至 12.60±2.06 mm。这两项测量结果均有统计学意义(P=0.0001)。术后12个月,CT轴向前后距离为12.09±1.4 mm,内外侧平均距离为19.82±5.6 mm,而术前CT前后距离为15.60±2 mm,内外侧平均距离为21.28±2.7 mm。前胸测量结果有统计学意义(P=0.002),而内外侧测量结果无统计学意义(P=0.3)。手术前的平均绒毛长度为 25.80±1.5 毫米,术后 12 个月后的平均绒毛长度为 27.03±0.6 毫米。术后1、6和12个月对打鼾和鼻反流进行了评估,所有报告均为阴性:结论:使用扁桃体后支柱进行括约肌咽成形术治疗 VPI 患者可改善语言效果,且不会出现打鼾或鼻腔反流。
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引用次数: 0
Revolutionizing ECG monitoring: the integrated belt device for reliable ECG strip placement - a letter to the editor. 革命性的心电图监测:用于可靠放置心电图条的集成腰带装置--致编辑的一封信。
IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-19 eCollection Date: 2024-11-01 DOI: 10.1097/MS9.0000000000002568
Nima Eskandari, Rasoul Goli, Navid Faraji
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引用次数: 0
期刊
Annals of Medicine and Surgery
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