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Τhe Study of Square Periodic Perturbations as an Immunotherapy Process on a Tumor Growth Chaotic Model Τhe方形周期扰动作为肿瘤生长混沌模型免疫治疗过程的研究
Pub Date : 2022-06-06 DOI: 10.3390/dynamics2020008
Dionysios Sourailidis, C. Volos, L. Moysis, E. Meletlidou, I. Stouboulos
In the present study, the simulation of an immunotherapy effect for a known dynamical system, that describes the process for avascular, vascular, and metastasis tumor growth based on a chemical network model, has been presented. To this end, square signals of various amplitudes have been used, to model the effect of external therapy control, in order to affect the population of immune cells. The results of the simulations show that for certain values of the amplitude of the square signal, the populations of the proliferating tumor cells in the vascular and metastasis stages have been reduced.
在本研究中,免疫治疗对一个已知动力系统的影响进行了模拟,该系统描述了基于化学网络模型的无血管、血管和转移性肿瘤生长过程。为此,已使用各种幅度的平方信号来模拟外部治疗控制的效果,以影响免疫细胞的数量。模拟结果表明,在一定的平方信号幅值下,血管期和转移期的增殖肿瘤细胞数量有所减少。
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引用次数: 1
Robustness of Optimal Sensor Methods in Dynamic Testing–Comparison and Implementation on a Footbridge 动态测试中最优传感器方法的鲁棒性——人行天桥的比较与实现
Pub Date : 2022-06-04 DOI: 10.3390/dynamics2020007
Marc Lizana, J. Casas
One of the objectives of structural health monitoring (SHM) is to maximize the information while keeping the number of sensors, and consequently the cost of the sensor system, to a minimum. Besides, the sensor configurations must be robust in the sense that the feasibility of small errors inherent to the process must not lead to large variations in the final results. This paper presents novelties regarding the robustness evaluation to model and measurement errors of four of the most influential optimal sensor placement (OSP) methods: the modal kinetic energy (MKE) method; the effective independence (EFI) method; the information entropy index (IEI) method; and the MinMAC method. The four OSP methods were implemented on the Streicker Bridge, a footbridge located on the Princeton University Campus, to identify five mode shapes of the bridge. The mode shapes, obtained in a FE model’s modal analysis, were used as input data for the OSP analyses. The study indicates that the MKE method seems to be the most suitable method to estimate the optimal sensor positions: it provides a relatively large amount of information with the lowest computational time, and it outperforms the other three methods in terms of robustness in the usual range of number of sensors.
结构健康监测(SHM)的目标之一是最大化信息,同时保持传感器的数量,从而使传感器系统的成本降至最低。此外,传感器配置必须具有鲁棒性,即过程固有的小误差的可行性不得导致最终结果的大变化。本文介绍了四种最具影响力的最优传感器放置(OSP)方法的模型鲁棒性评价和测量误差方面的新进展:模态动能(MKE)方法;有效独立性(EFI)法;信息熵指数(IEI)法;以及MinMAC方法。四种OSP方法在Streicker桥上实施,这是一座位于普林斯顿大学校园的人行桥,以确定桥梁的五种模态振型。在有限元模型的模态分析中得到的模态振型被用作OSP分析的输入数据。研究表明,MKE方法似乎是最适合估计最优传感器位置的方法:它以最少的计算时间提供了相对大量的信息,并且在通常的传感器数量范围内,它的鲁棒性优于其他三种方法。
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引用次数: 0
On The Biophysical Complexity of Brain Dynamics: An Outlook 脑动力学的生物物理复杂性:展望
Pub Date : 2022-05-05 DOI: 10.3390/dynamics2020006
N. Shettigar, Chunbin Yang, Kuan-Chung Tu, C. Suh
The human brain is a complex network whose ensemble time evolution is directed by the cumulative interactions of its cellular components, such as neurons and glia cells. Coupled through chemical neurotransmission and receptor activation, these individuals interact with one another to varying degrees by triggering a variety of cellular activity from internal biological reconfigurations to external interactions with other network agents. Consequently, such local dynamic connections mediating the magnitude and direction of influence cells have on one another are highly nonlinear and facilitate, respectively, nonlinear and potentially chaotic multicellular higher-order collaborations. Thus, as a statistical physical system, the nonlinear culmination of local interactions produces complex global emergent network behaviors, enabling the highly dynamical, adaptive, and efficient response of a macroscopic brain network. Microstate reconfigurations are typically facilitated through synaptic and structural plasticity mechanisms that alter the degree of coupling (magnitude of influence) neurons have upon each other, dictating the type of coordinated macrostate emergence in populations of neural cells. These can emerge in the form of local regions of synchronized clusters about a center frequency composed of individual neural cell collaborations as a fundamental form of collective organization. A single mode of synchronization is insufficient for the computational needs of the brain. Thus, as neural components influence one another (cellular components, multiple clusters of synchronous populations, brain nuclei, and even brain regions), different patterns of neural behavior interact with one another to produce an emergent spatiotemporal spectral bandwidth of neural activity corresponding to the dynamical state of the brain network. Furthermore, hierarchical and self-similar structures support these network properties to operate effectively and efficiently. Neuroscience has come a long way since its inception; however, a comprehensive and intuitive understanding of how the brain works is still amiss. It is becoming evident that any singular perspective upon the grandiose biophysical complexity within the brain is inadequate. It is the purpose of this paper to provide an outlook through a multitude of perspectives, including the fundamental biological mechanisms and how these operate within the physical constraints of nature. Upon assessing the state of prior research efforts, in this paper, we identify the path future research effort should pursue to inspire progress in neuroscience.
人脑是一个复杂的网络,其集合时间进化是由其细胞成分(如神经元和神经胶质细胞)的累积相互作用指导的。通过化学神经传递和受体激活,这些个体通过触发各种细胞活动,从内部生物重组到与其他网络代理的外部相互作用,在不同程度上相互作用。因此,这种局部动态连接介导细胞对彼此的影响程度和方向是高度非线性的,并分别促进非线性和潜在混沌的多细胞高阶协作。因此,作为一个统计物理系统,局部相互作用的非线性顶点产生复杂的全局突发网络行为,使宏观大脑网络的高度动态、自适应和高效响应成为可能。微观状态的重新配置通常通过突触和结构可塑性机制来促进,这些机制改变了神经元相互之间的耦合程度(影响的大小),从而决定了神经细胞群体中协调的宏观状态出现的类型。这些可以以同步集群的局部区域的形式出现,这些集群的中心频率由单个神经细胞协作组成,作为集体组织的基本形式。单一的同步模式不足以满足大脑的计算需求。因此,当神经成分相互影响时(细胞成分、同步种群的多个集群、脑核甚至脑区域),不同的神经行为模式相互作用,产生与脑网络动态状态相对应的神经活动的紧急时空频谱带宽。此外,分层和自相似的结构支持这些网络属性有效和高效地运行。神经科学自诞生以来已经走过了漫长的道路;然而,对大脑如何工作的全面和直观的理解仍然是错误的。越来越明显的是,对于大脑中宏大的生物物理复杂性,任何单一的观点都是不够的。本文的目的是通过多种角度提供展望,包括基本的生物学机制以及这些机制如何在自然的物理约束下运作。在评估先前研究工作的状态后,在本文中,我们确定了未来研究工作应该追求的路径,以激发神经科学的进步。
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引用次数: 4
Review of the Dynamics of Atomic and Molecular Systems of Higher than Geometric Symmetry—Part I: One-Electron Rydberg Quasimolecules 高度几何对称的原子和分子系统动力学综述——第一部分:单电子Rydberg准分子
Pub Date : 2022-04-21 DOI: 10.3390/dynamics2020005
N. Kryukov, E. Oks
The review covers the dynamics of different kinds of one electron Rydberg quasimolecules in various environments, such as being subjected to electric and/or magnetic fields or to a plasma environment. The higher than geometrical symmetry of these systems is due to the existence of an additional conserved quantity: the projection of the supergeneralized Runge–Lenz vector on the internuclear axis. The review emphasizes the fundamental and practical importance of the results concerning the dynamics of these systems.
综述了不同类型的单电子里德伯准分子在不同环境下的动力学,如电场和/或磁场或等离子体环境。这些系统的高几何对称性是由于一个额外的守恒量的存在:超广义龙格-伦茨向量在核间轴上的投影。这篇综述强调了这些系统动力学结果的基础和实际重要性。
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引用次数: 0
Characterising Single and Two-Phase Homogeneous Isotropic Turbulence with Stagnation Points 具有驻点的单相和两相均匀各向同性湍流的特征
Pub Date : 2022-04-15 DOI: 10.3390/dynamics2020004
Amélie Ferran, S. Angriman, P. Mininni, M. Obligado
It has been shown that, for dense, sub-Kolmogorov particles advected in a turbulent flow, carrier phase properties can be reconstructed from the particles’ velocity field. For that, the instantaneous particles’ velocity field can be used to detect the stagnation points of the carrier phase. The Rice theorem can therefore be used, implying that the Taylor length is proportional to the mean distance between such stagnation points. As this model has been only tested for one-dimensional time signals, this work discusses if it can be applied to two-phase, three-dimensional flows. We use direct numerical simulations with turbulent Reynolds numbers Reλ between 40 and 520 and study particle-laden flows with a Stokes number of St=0.5. We confirm that for the carrier phase, the Taylor length is proportional to the mean distance between stagnation points with a proportionality coefficient that depends weakly on Reλ. Then, we propose an interpolation scheme to reconstruct the stagnation points of the particles’ velocity field. The results indicate that the Rice theorem cannot be applied in practice to two-phase three-dimensional turbulent flows, as the clustering of stagnation points forms very dense structures that require a very large number of particles to accurately sample the flow stagnation points.
研究表明,对于在湍流中平流的密集亚kolmogorov粒子,可以通过粒子的速度场来重建载流子相性质。因此,瞬时粒子速度场可以用来检测载相的驻点。因此可以使用赖斯定理,这意味着泰勒长度与这些停滞点之间的平均距离成正比。由于该模型仅对一维时间信号进行了测试,因此本工作讨论了它是否可以应用于两相三维流动。我们使用湍流雷诺数Reλ介于40和520之间的直接数值模拟,并研究了Stokes数St=0.5的颗粒负载流。我们证实,对于载波相位,泰勒长度与驻点之间的平均距离成正比,其比例系数弱依赖于Reλ。然后,我们提出了一种插值方案来重建粒子速度场的停滞点。结果表明,Rice定理在实际中不能应用于两相三维湍流,因为驻点的聚集形成了非常密集的结构,需要非常多的粒子才能准确地采样流动的驻点。
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引用次数: 2
Modal Analysis of a Discrete Tire Model with a Contact Patch and Rolling Conditions Using the Finite Difference Method 用有限差分法分析具有接触片和滚动条件的离散轮胎模型
Pub Date : 2022-03-31 DOI: 10.3390/dynamics2020003
Faisal A. Alobaid, S. Taheri
Obtaining the modal parameters of a tire with ground contact and rolling conditions represents a challenge due to the complex vibration characteristic behaviors that cause the distortion of the tire’s symmetry and the bifurcation phenomena of the natural frequencies. An in-plane rigid–elastic-coupled tire model was used to examine the 200 DOF finite difference method (FDM) modal analysis accuracy under non-ground contact and non-rotating conditions. The discrete in-plane rigid–elastic-coupled tire model was modified to include the contact patch restriction, centrifugal force and Coriolis effect, covering a range from 0 to 300 Hz. As a result, the influence of the contact patch and the rotating tire conditions on the natural frequencies and modes were obtained through modal analysis.
由于轮胎具有复杂的振动特性,会导致轮胎对称性的畸变和固有频率的分岔现象,因此在接触地面和滚动条件下获得轮胎的模态参数是一项挑战。采用平面内刚弹耦合轮胎模型,对200自由度有限差分法(FDM)在非地面接触和非旋转条件下的模态分析精度进行了验证。对离散平面内刚弹耦合轮胎模型进行了修正,加入了接触片约束、离心力和科里奥利效应,覆盖范围为0 ~ 300 Hz。通过模态分析,得到了接触贴片和轮胎工况对轮胎固有频率和固有模态的影响。
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引用次数: 3
Aerodynamic-Torque Induced Motions of a Spinning Football and Why the Ball’s Longitudinal Axis Rotates with the Linear Velocity Vector 旋转足球的空气动力扭矩诱导运动及球纵轴随线速度矢量旋转的原因
Pub Date : 2022-01-26 DOI: 10.3390/dynamics2010002
J. Dzielski, Mark Blackburn
This paper presents an explanation of why a spinning football rotates so that the spin axis remains nearly aligned with the velocity vector, and approximately parallel to the tangent to the trajectory. The paper derives the values of the characteristic frequencies associated with the football’s precession and nutation. The paper presents a graphical way of visualizing how the motions associated with these frequencies result in the observed “wobble” of the football. A solution for the linearized dynamics shows that there is a minimum amount of spin required for the motion to be stable and for the football not to tumble. This paper notes the similarity of this problem to that of spun projectiles. The results show that the tendency of a football to align itself with and rotate with the velocity vector is associated with an equilibrium condition with a non-zero aerodynamic torque. The torque is precisely the value required for the football to rotate at the same angular rate as the velocity vector. An implication of this is that a release with the football spin axis and velocity vector aligned (zero aerodynamic torque) is not the condition that results in minimum motion after release. Minimum “wobble” occurs when the ball is released with its symmetry axis slightly to the right or left of the velocity vector, depending on the direction of the spin. There are additional forces and moments acting on the football that affect its trajectory and its stability, but it is not necessary to consider these to explain the tendency of the ball to align with the velocity vector and to ”wobble.” The results of this paper are equally applicable to the spiral pass in American football and the screw kick in rugby.
本文提出了一个解释,为什么一个旋转的足球旋转,使自转轴保持几乎对齐的速度矢量,并近似平行于切线的轨迹。本文导出了与足球岁差和章动有关的特征频率值。本文提出了一种图形化的方式来可视化与这些频率相关的运动如何导致观察到的足球“摆动”。线性化动力学的解表明,有一个最小的旋转所需的运动是稳定的,并为足球不翻滚。本文注意到这个问题与旋转弹丸问题的相似之处。结果表明,足球与速度矢量对齐并随速度矢量旋转的趋势与非零气动力矩的平衡条件有关。这个扭矩正好是使足球以与速度矢量相同的角速度旋转所需的值。这意味着,与足球旋转轴和速度矢量对齐的释放(零空气动力扭矩)并不是导致释放后最小运动的条件。当球被释放时,它的对称轴稍微向速度矢量的右边或左边移动,这取决于旋转的方向,最小的“摆动”发生。作用在足球上的额外的力和力矩会影响它的轨迹和稳定性,但没有必要考虑这些来解释足球与速度矢量对齐和“摆动”的趋势。本文的研究结果同样适用于美式足球的螺旋传球和英式橄榄球的螺旋踢腿。
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引用次数: 0
Analysis of Three-Dimensional Rigid-Body Impact with Friction 三维刚体碰撞与摩擦分析
Pub Date : 2022-01-21 DOI: 10.3390/dynamics2010001
Han-Xiao Sun, H. Baruh
This paper is concerned with the modeling and simulation of two- and three-dimensional impact in the presence of friction. Single impacts are considered, and the impact equations are solved algebraically. Impact generates impulsive normal and frictional forces and the direction of sliding can change during impact. A procedure is developed to estimate the change in direction of sliding during three-dimensional impact. The modes of impact, such as sliding, sticking, or change in direction of sliding, are classified for both two- and three-dimensional impact. Simulations are conducted to analyze the energy lost, change in impact direction, and stick-slip conditions, where different models for restitution are compared. A closed-form solution is developed to analyze the modes of sliding for two-dimensional impact.
本文研究了存在摩擦的二维和三维碰撞的建模和仿真。考虑了单次冲击,并对冲击方程进行了代数求解。冲击产生脉冲法向力和摩擦力,并且在冲击过程中滑动方向可以改变。提出了一种估算三维冲击过程中滑动方向变化的方法。碰撞的模式,如滑动、粘着或改变滑动方向,分为二维和三维碰撞。通过仿真分析了能量损失、冲击方向变化和粘滑情况,比较了不同的恢复模型。提出了一种分析二维碰撞滑动模态的封闭解。
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引用次数: 1
Modeling of an Innovative Nitrogen-Free Cryotherapy Device 一种新型无氮冷冻治疗装置的建模
Pub Date : 2021-12-16 DOI: 10.3390/dynamics1020013
F. Beaumont, F. Bogard, H. Hakim, S. Murer, B. Bouchet, G. Polidori
Partial body cryotherapy cabins most often use liquid nitrogen as their cryogenic fluid, which raises safety concerns during operation. In this study, an innovative cryotherapy cabin design is presented, featuring an electric cooling system suitable for producing cold air at −30 °C. The geometry of the designed cryotherapy cabin is evaluated by a thermodynamic modeling which aims at optimizing the circulation of cold air flows inside the cabin. The numerical study is carried out in two successive phases, the first one being necessary to model the pre-cooling phase and to estimate the time required to reach an average temperature close to the set temperature of −30 °C. The second one aims at modeling a 3-min cryotherapy session by taking into account the thermal transfers between the human body and its environment. Results demonstrate the potential benefits of the cold air injection device which has been designed to optimize the thermal transfers and homogenize the temperatures within the therapeutic enclosure. The main innovation of this study is the ability to customize cryotherapy protocols by injecting cold air at different levels through targeting of specific body areas. Further calculations would be required to determine the precise impact of zone-targeted injection on skin cooling.
部分身体冷冻治疗室通常使用液氮作为其低温流体,这引起了操作期间的安全问题。在这项研究中,提出了一种创新的冷冻治疗舱设计,其特点是一个适合在- 30°C产生冷空气的电动冷却系统。设计的冷冻治疗舱的几何形状是通过热力学模型来评估的,该模型旨在优化舱内冷空气流动的循环。数值研究分两个连续阶段进行,第一个阶段是模拟预冷阶段和估计达到接近- 30°C设定温度的平均温度所需的时间。第二个目标是通过考虑人体与环境之间的热传递来模拟3分钟的冷冻治疗过程。结果证明了冷空气注射装置的潜在好处,该装置被设计用于优化热传递和均匀化治疗外壳内的温度。这项研究的主要创新是能够通过针对特定身体区域注入不同水平的冷空气来定制冷冻治疗方案。需要进一步的计算来确定区域靶向注射对皮肤冷却的精确影响。
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引用次数: 2
On the Zero-Neutron Density in Stochastic Nuclear Dynamics 随机核动力学中的零中子密度
Pub Date : 2021-11-04 DOI: 10.3390/dynamics1020012
F. Vadillo
In this short paper, we compare the deterministic model for the nuclear reactor dynamic (Hetrick, 1993) with the stochastic model (Kinard and Allen, 2004). Our numerical results show coincidences between the deterministic model and the mean of the stochastic paths, although, as already observed by other authors, there is alarge amount of dispersion between the individual paths. Notably, we always observe that the neutron density approaches zero within a short time. In this paper, we investigate this question; more concretely, we study the mean-extinction of the neutron density. The technique used here first builds the backward Kolmogorov differential equation and then solves it numerically using the finite-element method with FreeFem++. Our results confirm that in a very short time the neutrons disappear although later they recover probably due to the external source.
在这篇短文中,我们比较了核反应堆动力学的确定性模型(Hetrick, 1993)和随机模型(Kinard and Allen, 2004)。我们的数值结果表明确定性模型和随机路径的平均值之间是一致的,尽管正如其他作者已经观察到的那样,个别路径之间存在大量的分散。值得注意的是,我们总是观察到中子密度在短时间内趋于零。本文对这一问题进行了研究;更具体地说,我们研究了中子密度的平均消光。本文采用的技术首先建立倒向Kolmogorov微分方程,然后使用FreeFem++进行有限元数值求解。我们的结果证实,中子在很短的时间内消失,但后来可能由于外部源的作用而恢复。
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引用次数: 1
期刊
Dynamics (Pembroke, Ont.)
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