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Cumulative Chapter Titles Keyword Index, Volume 1 - 50. 累积章节标题关键词索引，卷1 - 50。
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2017-01-01 Epub Date: 2017-11-20 DOI: 10.1016/S0065-7743(17)30031-3
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引用次数: 0
Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development. 铅中细胞色素P450酶代谢物的发现与开发。
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00022-5
Sylvie E Kandel, Larry C Wienkers, Jed N Lampe

The cytochrome P450 (CYP) enzymes are a versatile superfamily of heme-containing monooxygenases, perhaps best known for their role in the oxidation of xenobiotic compounds. However, due to their unique oxidative chemistry, CYPs are also important in natural product drug discovery and in the generation of active metabolites with unique therapeutic properties. New tools for the analysis and production of CYP metabolites, including microscale analytical technologies and combinatorial biosynthesis, are providing medicinal chemists with the opportunity to use CYPs as a novel platform for lead discovery and development. In this review, we will highlight some of the recent examples of drug leads identified from CYP metabolites and the exciting possibilities of using CYPs as catalysts for future drug discovery.

细胞色素P450 (CYP)酶是一种多用途的含血红素单加氧酶超家族，可能以其在氧化异种化合物中的作用而闻名。然而，由于其独特的氧化化学性质，CYPs在天然产物药物的发现和具有独特治疗特性的活性代谢物的产生中也很重要。用于分析和生产CYP代谢物的新工具，包括微尺度分析技术和组合生物合成，为药物化学家提供了将CYP作为先导物质发现和开发的新平台的机会。在这篇综述中，我们将重点介绍最近从CYP代谢物中发现的一些药物先导的例子，以及使用CYP作为未来药物发现催化剂的令人兴奋的可能性。
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引用次数: 3
Chapter Six - Small-Molecule Modulators of GPR40 (FFA1) 第六章- GPR40 (FFA1)的小分子调节剂
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00006-7
Sean P. Brown, Joshua P. Taygerly
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引用次数: 3
Chapter Thirteen - Modulators of Atypical Protein Kinase C as Anticancer Agents 第十三章:非典型蛋白激酶C作为抗癌药物的调节剂
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00013-4
J. Roffey, G. R. Ott
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引用次数: 0
Chapter Twenty - Disease-Modifying Agents for the Treatment of Cystic Fibrosis 第二十章-治疗囊性纤维化的减肥剂
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00020-1
B. Tait, J. Miller
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引用次数: 2
Chapter Twenty-One – Advancements in Stapled Peptide Drug Discovery & Development 第二十一章-钉接肽药物的发现与开发进展
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00021-3
V. Guerlavais, T. Sawyer
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引用次数: 11
Chapter Nine - Advances in the Discovery of Small-Molecule IRAK4 Inhibitors 第九章-小分子IRAK4抑制剂的发现进展
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00009-2
J. Hynes, S. Nair
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引用次数: 18
Chapter Seven - Recent Advances in the Development of P2Y12 Receptor Antagonists as Antiplatelet Agents 第七章:P2Y12受体拮抗剂抗血小板的研究进展
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00007-9
Allorie T. Caldwell, E. B. Watkins
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引用次数: 4
Chapter Eight - Current Approaches to the Treatment of Atrial Fibrillation 第八章-目前治疗心房颤动的方法
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00008-0
Heather J. Finlay
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引用次数: 2
p53-MDM2 and MDMX Antagonists p53-MDM2和MDMX拮抗剂
4区 化学 Q3 Chemistry
Annual Reports in Medicinal Chemistry
Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800167-7.00012-2
Dinos Neochoritis, Natalia Estrada-Ortiz, Kareem Khoury, A. Dömling
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引用次数: 9
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