Pub Date : 2013-01-01DOI: 10.1016/B978-0-12-417150-3.00025-9
J. Cui, M. McTigue, K. Steven, M. Edwards
{"title":"Chapter Twenty-Five - Case History: Xalkori™ (Crizotinib), a Potent and Selective Dual Inhibitor of Mesenchymal Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) for Cancer Treatment","authors":"J. Cui, M. McTigue, K. Steven, M. Edwards","doi":"10.1016/B978-0-12-417150-3.00025-9","DOIUrl":"https://doi.org/10.1016/B978-0-12-417150-3.00025-9","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"48 1","pages":"421-434"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-417150-3.00025-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54122410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1016/B978-0-12-417150-3.00026-0
N. IbrahimPrabha, Jiazhong Zhang, Chao Zhang, G. Bollag
{"title":"Chapter Twenty-Six – Case History: Vemurafenib, a Potent, Selective, and First-in-Class Inhibitor of Mutant BRAF for the Treatment of Metastatic Melanoma","authors":"N. IbrahimPrabha, Jiazhong Zhang, Chao Zhang, G. Bollag","doi":"10.1016/B978-0-12-417150-3.00026-0","DOIUrl":"https://doi.org/10.1016/B978-0-12-417150-3.00026-0","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"48 1","pages":"435-449"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-417150-3.00026-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54122439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1016/B978-0-12-417150-3.00003-X
M. Maccoss
{"title":"Chapter Three - A Career in Medicinal Chemistry—A Journey in Drug Discovery","authors":"M. Maccoss","doi":"10.1016/B978-0-12-417150-3.00003-X","DOIUrl":"https://doi.org/10.1016/B978-0-12-417150-3.00003-X","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"48 1","pages":"23-34"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-417150-3.00003-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54121710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1016/B978-0-12-417150-3.00022-3
Muneto Mogi, C. Adams, N. Ji, N. Mainolfi
{"title":"Chapter Twenty-Two – Recent Progress in Small-Molecule Agents Against Age-Related Macular Degeneration","authors":"Muneto Mogi, C. Adams, N. Ji, N. Mainolfi","doi":"10.1016/B978-0-12-417150-3.00022-3","DOIUrl":"https://doi.org/10.1016/B978-0-12-417150-3.00022-3","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"48 1","pages":"353-369"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-417150-3.00022-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54122370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1016/B978-0-12-417150-3.00027-2
G. Notte
{"title":"Chapter Twenty-Seven - New Chemical Entities Entering Phase III Trials in 2012","authors":"G. Notte","doi":"10.1016/B978-0-12-417150-3.00027-2","DOIUrl":"https://doi.org/10.1016/B978-0-12-417150-3.00027-2","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"48 1","pages":"451-469"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-417150-3.00027-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54122487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1016/B978-0-12-417150-3.00002-8
C. Lipinski
{"title":"Chapter Two - My Perspective on Time, Managers—and Scientific Fun","authors":"C. Lipinski","doi":"10.1016/B978-0-12-417150-3.00002-8","DOIUrl":"https://doi.org/10.1016/B978-0-12-417150-3.00002-8","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"13 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-417150-3.00002-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54121666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1016/B978-0-12-417150-3.00009-0
David J. Edmonds, David A. Price
{"title":"Chapter Nine - Oral GLP-1 Modulators for the Treatment of Diabetes","authors":"David J. Edmonds, David A. Price","doi":"10.1016/B978-0-12-417150-3.00009-0","DOIUrl":"https://doi.org/10.1016/B978-0-12-417150-3.00009-0","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"48 1","pages":"119-130"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-417150-3.00009-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54121838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1016/B978-0-12-417150-3.00023-5
V. Helene, M. Cummings
{"title":"Chapter Twenty-Three – Synthetic Macrocycles in Small-Molecule Drug Discovery","authors":"V. Helene, M. Cummings","doi":"10.1016/B978-0-12-417150-3.00023-5","DOIUrl":"https://doi.org/10.1016/B978-0-12-417150-3.00023-5","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"48 1","pages":"371-386"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-417150-3.00023-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54122383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-12-31DOI: 10.1016/B978-0-12-396492-2.00003-5
M. Johnson
{"title":"Tales of Drug Discovery","authors":"M. Johnson","doi":"10.1016/B978-0-12-396492-2.00003-5","DOIUrl":"https://doi.org/10.1016/B978-0-12-396492-2.00003-5","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"47 1","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2012-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-396492-2.00003-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54091719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}