Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00024-9
Sabine Hadida, Goor Frederick F. Van, K. Dinehart, A. Looker, P. Mueller, P. Grootenhuis
{"title":"Chapter Twenty-Four – Case History: Kalydeco® (VX-770, Ivacaftor), a CFTR Potentiator for the Treatment of Patients with Cystic Fibrosis and the G551D-CFTR Mutation","authors":"Sabine Hadida, Goor Frederick F. Van, K. Dinehart, A. Looker, P. Mueller, P. Grootenhuis","doi":"10.1016/B978-0-12-800167-7.00024-9","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00024-9","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"383-398"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00024-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00027-4
J. Bronson, Amelia Black, M. Dhar, B. Ellsworth, J. R. Merritt
{"title":"Chapter Twenty-Seven – To Market, To Market—2013","authors":"J. Bronson, Amelia Black, M. Dhar, B. Ellsworth, J. R. Merritt","doi":"10.1016/B978-0-12-800167-7.00027-4","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00027-4","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"103 1","pages":"437-508"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00027-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00010-9
D. Burns, N. Shin, J. R. Kumar, W. Yao, P. Scherle
{"title":"Chapter Ten - H4 Receptor Antagonists and Their Potential Therapeutic Applications","authors":"D. Burns, N. Shin, J. R. Kumar, W. Yao, P. Scherle","doi":"10.1016/B978-0-12-800167-7.00010-9","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00010-9","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"135-149"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00010-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00025-0
M. Flanagan, Matthew F Brown, C. Subramanyam, M. Munchhof
{"title":"Chapter Twenty-Five - Case History: Xeljanz™ (Tofacitinib Citrate), a First-in-Class Janus Kinase Inhibitor for the Treatment of Rheumatoid Arthritis","authors":"M. Flanagan, Matthew F Brown, C. Subramanyam, M. Munchhof","doi":"10.1016/B978-0-12-800167-7.00025-0","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00025-0","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"399-416"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00025-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00011-0
J. Girardet, J. Miner
{"title":"Chapter Eleven - Urate Crystal Deposition Disease and Gout—New Therapies for an Old Problem","authors":"J. Girardet, J. Miner","doi":"10.1016/B978-0-12-800167-7.00011-0","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00011-0","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"151-164"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00011-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00018-3
S. Schann, P. Neuville, M. Bouvier
{"title":"Chapter Eighteen - Novel Screening Paradigms for the Identification of Allosteric Modulators and/or Biased Ligands for Challenging G-Protein-Coupled Receptors","authors":"S. Schann, P. Neuville, M. Bouvier","doi":"10.1016/B978-0-12-800167-7.00018-3","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00018-3","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"285-300"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00018-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00023-7
W. Washburn
{"title":"Chapter Twenty-Three - Case History: ForxigaTM (Dapagliflozin), a Potent Selective SGLT2 Inhibitor for Treatment of Diabetes","authors":"W. Washburn","doi":"10.1016/B978-0-12-800167-7.00023-7","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00023-7","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"363-382"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00023-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00003-1
G. Martínez-Botella, M. A. Ackley, F. Salituro, J. Doherty
{"title":"Chapter Three – Natural and Synthetic Neuroactive Steroid Modulators of GABAA and NMDA Receptors","authors":"G. Martínez-Botella, M. A. Ackley, F. Salituro, J. Doherty","doi":"10.1016/B978-0-12-800167-7.00003-1","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00003-1","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"27-42"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00003-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54158933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1016/B978-0-12-800167-7.00005-5
G. Nordvall, P. Forsell
{"title":"Chapter Five - Stimulating Neurotrophin Receptors in the Treatment of Neurodegenerative Disorders","authors":"G. Nordvall, P. Forsell","doi":"10.1016/B978-0-12-800167-7.00005-5","DOIUrl":"https://doi.org/10.1016/B978-0-12-800167-7.00005-5","url":null,"abstract":"","PeriodicalId":8033,"journal":{"name":"Annual Reports in Medicinal Chemistry","volume":"49 1","pages":"59-73"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800167-7.00005-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54159005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}