This study examines the anxiety levels of midwives and nurses working for filiation during management of the COVID-19 pandemic(n = 205) The cross-sectional data were collected using State-Trait Anxiety Inventory (STAI-I and II). Having COVID-19 test done and provision of protective equipment affected their STAI-I and II. High anxiety status was found to be those who did not experience fear of carrying the coronavirus to their families (O.R: 1.128), who had diagnosis tests done (O.R:0.888), who had good feeling states before COVID-19 process (O.R:1.076). Information about infection spreads, required equipment and providing social support will lead to a reduction in their anxiety levels in working filiation.
{"title":"The anxiety levels of midwives and nurses working for filiation during COVID-19: A sample of Turkey.","authors":"Eylem Toker, Mine Gökduman Keleş, Mehtap Omaç Sönmez","doi":"10.1080/19338244.2022.2118211","DOIUrl":"https://doi.org/10.1080/19338244.2022.2118211","url":null,"abstract":"<p><p>This study examines the anxiety levels of midwives and nurses working for filiation during management of the COVID-19 pandemic(n = 205) The cross-sectional data were collected using State-Trait Anxiety Inventory (STAI-I and II). Having COVID-19 test done and provision of protective equipment affected their STAI-I and II. High anxiety status was found to be those who did not experience fear of carrying the coronavirus to their families (O.R: 1.128), who had diagnosis tests done (O.R:0.888), who had good feeling states before COVID-19 process (O.R:1.076). Information about infection spreads, required equipment and providing social support will lead to a reduction in their anxiety levels in working filiation.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 3","pages":"142-151"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10869567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01Epub Date: 2023-02-27DOI: 10.1080/19338244.2023.2180614
Frank G Dowling, Sandra M Lowe
A growing body of research supports the association between direct exposure to the September 11, 2001, terrorist attacks, increased rates of alcohol and substance use and elevated risk of subsequent diagnosis with trauma-related and substance use disorders. Posttraumatic stress disorder (PTSD) is the most diagnosed psychiatric illness in individuals who witnessed the 9/11 attacks or participated in disaster response efforts, and substance use disorders (SUDs) are highly comorbid with PTSD. The presence of both conditions poses challenges for clinical management and highlights the importance of screening and offering intervention to this at-risk population. This paper provides background on substance use, SUDs, and co-occurring PTSD in trauma exposed populations, describes best practices for identifying harmful substance use, the role of psychotherapy and medication for addiction treatment (MAT), and recommendations for management of co-occurring SUD and PTSD.
{"title":"Substance use and related disorders among persons exposed to the 9/11 terrorist attacks: Essentials for screening and intervention.","authors":"Frank G Dowling, Sandra M Lowe","doi":"10.1080/19338244.2023.2180614","DOIUrl":"10.1080/19338244.2023.2180614","url":null,"abstract":"<p><p>A growing body of research supports the association between direct exposure to the September 11, 2001, terrorist attacks, increased rates of alcohol and substance use and elevated risk of subsequent diagnosis with trauma-related and substance use disorders. Posttraumatic stress disorder (PTSD) is the most diagnosed psychiatric illness in individuals who witnessed the 9/11 attacks or participated in disaster response efforts, and substance use disorders (SUDs) are highly comorbid with PTSD. The presence of both conditions poses challenges for clinical management and highlights the importance of screening and offering intervention to this at-risk population. This paper provides background on substance use, SUDs, and co-occurring PTSD in trauma exposed populations, describes best practices for identifying harmful substance use, the role of psychotherapy and medication for addiction treatment (MAT), and recommendations for management of co-occurring SUD and PTSD.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 5","pages":"261-266"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9856659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to examine the quality of work life (QoWL) and working conditions of oncology nurses in Turkey. The study utilized a descriptive cross-sectional design. The data were collected via the introductory information form and Brooks' Quality of Nursing Work Life Survey. The study was completed with 138 nurses. The factors affecting QoWL were determined using stepwise multiple linear regression. Nurses had a moderate QoWL, and age, duration of working in nursing, the number of nurses, and the working style were significantly associated with QoWL. To improve the QoWL, the nurses' socio-demographic factors should be considered and working conditions should be improved. Furthermore, well-designed institutional policies should be developed to improve the patient-nurse ratio and provide a quality healthcare.What this paper adds?In the current study, Turkish oncology nurses had a moderate quality of work life.Age, duration of working in the nursing, the number of nurses in the unit and the working style were linked to work-related quality of life in oncology nurses.Well-designed institutional policies should be developed to improve the working conditions and to increase work-related quality of life in oncology nurses.
{"title":"Quality of work life and working conditions among oncology nurses: A national online descriptive cross-sectional study.","authors":"Ayşe Arıkan Dönmez, Özlem Ovayolu, Nimet Ovayolu, Sakine Yılmaz, Özgül Karayurt, Gülsüm Nihal Çürük, Canan Pörücü, Hafize Güllü, Zeynep Yılmaz","doi":"10.1080/19338244.2022.2063240","DOIUrl":"https://doi.org/10.1080/19338244.2022.2063240","url":null,"abstract":"<p><p>The aim of this study was to examine the quality of work life (QoWL) and working conditions of oncology nurses in Turkey. The study utilized a descriptive cross-sectional design. The data were collected via the introductory information form and Brooks' Quality of Nursing Work Life Survey. The study was completed with 138 nurses. The factors affecting QoWL were determined using stepwise multiple linear regression. Nurses had a moderate QoWL, and age, duration of working in nursing, the number of nurses, and the working style were significantly associated with QoWL. To improve the QoWL, the nurses' socio-demographic factors should be considered and working conditions should be improved. Furthermore, well-designed institutional policies should be developed to improve the patient-nurse ratio and provide a quality healthcare.What this paper adds?In the current study, Turkish oncology nurses had a moderate quality of work life.Age, duration of working in the nursing, the number of nurses in the unit and the working style were linked to work-related quality of life in oncology nurses.Well-designed institutional policies should be developed to improve the working conditions and to increase work-related quality of life in oncology nurses.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 3","pages":"131-141"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10853062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1080/19338244.2022.2105287
W Kyle Mandler, Chaolong Qi, Yong Qian
Artificial countertop materials, including solid surface composites (SSC) and engineered stone (ES) may pose significant pulmonary health risks for workers who manipulate them. These materials have rapidly become popular in the multibillion-dollar countertop industry, rivaling that of natural materials such as granite and marble due to their variety of desirable esthetic qualities and reduced costs. Both SSC and ES consist of a mineral substrate bound together in a polymer matrix. For SSC the mineral is about 70% aluminum trihydrate (ATH) while ES contains up to 95% crystalline silica by weight. Both materials emit airborne dusts when being manipulated with power tools during the fabrication process. Several deaths and dozens of cases of silicosis have been identified worldwide in workers who fabricate ES, while a single case of fatal pulmonary fibrosis has been associated with SCC dust exposure. This review examines the current state of knowledge for both SSC and ES regarding the composition, particle emission characteristics, workplace exposure data, particle constituent toxicity, and possible methods for reducing worker exposure.
{"title":"Hazardous dusts from the fabrication of countertop: a review.","authors":"W Kyle Mandler, Chaolong Qi, Yong Qian","doi":"10.1080/19338244.2022.2105287","DOIUrl":"https://doi.org/10.1080/19338244.2022.2105287","url":null,"abstract":"<p><p>Artificial countertop materials, including solid surface composites (SSC) and engineered stone (ES) may pose significant pulmonary health risks for workers who manipulate them. These materials have rapidly become popular in the multibillion-dollar countertop industry, rivaling that of natural materials such as granite and marble due to their variety of desirable esthetic qualities and reduced costs. Both SSC and ES consist of a mineral substrate bound together in a polymer matrix. For SSC the mineral is about 70% aluminum trihydrate (ATH) while ES contains up to 95% crystalline silica by weight. Both materials emit airborne dusts when being manipulated with power tools during the fabrication process. Several deaths and dozens of cases of silicosis have been identified worldwide in workers who fabricate ES, while a single case of fatal pulmonary fibrosis has been associated with SCC dust exposure. This review examines the current state of knowledge for both SSC and ES regarding the composition, particle emission characteristics, workplace exposure data, particle constituent toxicity, and possible methods for reducing worker exposure.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 2","pages":"118-126"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909587/pdf/nihms-1861697.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10746869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01Epub Date: 2023-03-13DOI: 10.1080/19338244.2023.2188152
Geoffrey M Calvert, Gerald Lilly, John Cochran
The events of September 11, 2001 (9/11) exposed nearly a half million persons to many carcinogenic chemicals and dusts, as well as psychological and physical stressors. Subsequent epidemiologic studies of 9/11-exposed persons have suggested elevated risks for some cancers, e.g., prostate cancer, thyroid cancer, and melanoma. To detect cancer at an early stage, the US Preventive Services Task Force recommends screening certain asymptomatic persons for lung, colorectal, cervical and breast cancer, but not for other cancers. High quality cancer diagnosis and treatment guidelines are available from the National Comprehensive Cancer Network and the National Cancer Institute. For enrolled members, the WTC Health Program provides coverage for cancer screening and diagnosis, and covers medically necessary treatment costs for all types of cancer, assuming 9/11-exposure and minimum latency requirements are met, and a Program-affiliated physician attests that 9/11 exposures were substantially likely to have been a significant factor in aggravating, contributing to, or causing the enrolled WTC member's cancer.
{"title":"The World Trade Center Health Program: Cancer screening and cancer care best practices.","authors":"Geoffrey M Calvert, Gerald Lilly, John Cochran","doi":"10.1080/19338244.2023.2188152","DOIUrl":"10.1080/19338244.2023.2188152","url":null,"abstract":"<p><p>The events of September 11, 2001 (9/11) exposed nearly a half million persons to many carcinogenic chemicals and dusts, as well as psychological and physical stressors. Subsequent epidemiologic studies of 9/11-exposed persons have suggested elevated risks for some cancers, e.g., prostate cancer, thyroid cancer, and melanoma. To detect cancer at an early stage, the US Preventive Services Task Force recommends screening certain asymptomatic persons for lung, colorectal, cervical and breast cancer, but not for other cancers. High quality cancer diagnosis and treatment guidelines are available from the National Comprehensive Cancer Network and the National Cancer Institute. For enrolled members, the WTC Health Program provides coverage for cancer screening and diagnosis, and covers medically necessary treatment costs for all types of cancer, assuming 9/11-exposure and minimum latency requirements are met, and a Program-affiliated physician attests that 9/11 exposures were substantially likely to have been a significant factor in aggravating, contributing to, or causing the enrolled WTC member's cancer.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 4","pages":"222-228"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9668823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1080/19338244.2023.2188153
Sandra M Lowe, Peter T Haugen, Rebecca Rosen, Aditi S Werth
The relationship between exposure to the World Trade Center (WTC) disaster and elevated rates of trauma related psychiatric illnesses in 9/11 responders and survivors has been well documented. This paper is part of a series to promote the practice of evidence-based medicine when managing persons with WTC-related conditions and focuses on "Trauma and Stressor Related Disorders," a diagnostic category that includes posttraumatic stress disorder (PTSD) and adjustment disorder. It offers background on 9/11-related trauma exposure, a summary of research findings from this cohort, and is followed by brief diagnostic and treatment information from selected clinical practice guidelines.
{"title":"World Trade Center psychological exposures and trauma related disorders: PTSD and adjustment disorders.","authors":"Sandra M Lowe, Peter T Haugen, Rebecca Rosen, Aditi S Werth","doi":"10.1080/19338244.2023.2188153","DOIUrl":"https://doi.org/10.1080/19338244.2023.2188153","url":null,"abstract":"<p><p>The relationship between exposure to the World Trade Center (WTC) disaster and elevated rates of trauma related psychiatric illnesses in 9/11 responders and survivors has been well documented. This paper is part of a series to promote the practice of evidence-based medicine when managing persons with WTC-related conditions and focuses on \"Trauma and Stressor Related Disorders,\" a diagnostic category that includes posttraumatic stress disorder (PTSD) and adjustment disorder. It offers background on 9/11-related trauma exposure, a summary of research findings from this cohort, and is followed by brief diagnostic and treatment information from selected clinical practice guidelines.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 4","pages":"216-221"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9724595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1080/19338244.2022.2161456
Josefa Cristina Pereira Dos Santos, Joanina Bicalho Valli, Nixon Souza Sesse, Sarah Mackenzie Ross, Eliana Zandonade, Lorena Rocha Ayres, Karla Nívea Sampaio
This work aimed to identify variables associated with increased risk of outcome severity as well as to describe clinical manifestations/symptoms and management of pesticide-related cases reported to a poison center in Brazil. An increased risk of more severe outcomes was observed when exposures occurred in rural areas, involved suicide attempts and moderately to extremely hazardous pesticides. Clinical manifestations with higher frequencies included vomiting, nausea, sialorrhea, headache, miosis and sweating. From the treatment initially applied to the patient, 51.91% encompassed gastric lavage, but this procedure was only recommended in 20.01% of cases by the CIATox. Identifying risk factors associated with poor outcome, describing clinical manifestations, and contrasting initial treatment measures adopted against those recommended by the Poison Center can help determine diagnosis, prognosis and ensure appropriate clinical interventions are used in cases of pesticide poisoning.
{"title":"Pesticide exposure and poisoning in Brazil: Outcome severity, clinical manifestations and management of cases reported to a poison control center.","authors":"Josefa Cristina Pereira Dos Santos, Joanina Bicalho Valli, Nixon Souza Sesse, Sarah Mackenzie Ross, Eliana Zandonade, Lorena Rocha Ayres, Karla Nívea Sampaio","doi":"10.1080/19338244.2022.2161456","DOIUrl":"https://doi.org/10.1080/19338244.2022.2161456","url":null,"abstract":"<p><p>This work aimed to identify variables associated with increased risk of outcome severity as well as to describe clinical manifestations/symptoms and management of pesticide-related cases reported to a poison center in Brazil. An increased risk of more severe outcomes was observed when exposures occurred in rural areas, involved suicide attempts and moderately to extremely hazardous pesticides. Clinical manifestations with higher frequencies included vomiting, nausea, sialorrhea, headache, miosis and sweating. From the treatment initially applied to the patient, 51.91% encompassed gastric lavage, but this procedure was only recommended in 20.01% of cases by the CIATox. Identifying risk factors associated with poor outcome, describing clinical manifestations, and contrasting initial treatment measures adopted against those recommended by the Poison Center can help determine diagnosis, prognosis and ensure appropriate clinical interventions are used in cases of pesticide poisoning.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 3","pages":"177-186"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9073972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1080/19338244.2022.2134282
Melissa Bopp, Oliver W A Wilson, Lucas D Elliott, Kelsey E Holland, Michele Duffey, Zack Papalia
Occupational physical activity (OPA) is related to positive health outcomes and meeting overall physical activity recommendations. OPA participation typically varies across racial/ethnic groups and by gender, though little research has examined differences in OPA among college students. A cross-sectional, online survey of college students examined demographics and OPA. Participants (n = 3739) were predominately Non-Hispanic White (77.1%) and female (57.8%) aged 20.97 ± 1.52. Employed students reported greater total PA compared with non-employed students. Males reported significantly greater vigorous OPA, overall OPA, and total PA compared with females. Among employed students, OPA contributed significantly to overall PA levels. Males reported significantly greater OPA compared with females and there were several significant differences by race/ethnicity. Academic performance was related to OPA. These findings provide some insight on the OPA levels of a population group that has not been thoroughly examined.
{"title":"Gender and race/ethnicity differences in occupational activity among students.","authors":"Melissa Bopp, Oliver W A Wilson, Lucas D Elliott, Kelsey E Holland, Michele Duffey, Zack Papalia","doi":"10.1080/19338244.2022.2134282","DOIUrl":"https://doi.org/10.1080/19338244.2022.2134282","url":null,"abstract":"<p><p>Occupational physical activity (OPA) is related to positive health outcomes and meeting overall physical activity recommendations. OPA participation typically varies across racial/ethnic groups and by gender, though little research has examined differences in OPA among college students. A cross-sectional, online survey of college students examined demographics and OPA. Participants (<i>n</i> = 3739) were predominately Non-Hispanic White (77.1%) and female (57.8%) aged 20.97 ± 1.52. Employed students reported greater total PA compared with non-employed students. Males reported significantly greater vigorous OPA, overall OPA, and total PA compared with females. Among employed students, OPA contributed significantly to overall PA levels. Males reported significantly greater OPA compared with females and there were several significant differences by race/ethnicity. Academic performance was related to OPA. These findings provide some insight on the OPA levels of a population group that has not been thoroughly examined.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 3","pages":"170-176"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1080/19338244.2023.2185189
Eman A A Abdallah, Abdullah Almilaibary, Mohamed F El-Refaei
Chromium (Cr) is an environmental pollutant, has high redox potential, and can exist in various oxidation states, possibly leading to nephrotoxicity. As a potential treatment option, Fagonia indica (F. indica) is an herb remedy traditionally used as a phytomedicine to cure ailments. However, efficient validation of its protective effect and molecular mechanisms has not yet been established. As such, this study aims to investigate the protective effect of F. indica against Cr-induced nephrotoxicity in Swiss mice. Mice were divided into five groups: group I (negative control), group II (F. indica), group III (potassium dichromate [PDC]-treated), group IV (PDC + saline), and group V (PDC + F. indica). Our results demonstrate that group III exhibited decreases in superoxide dismutase (SOD), glutathione s-transferases (GST), glutathione peroxidase (GSH-Px), catalase (CAT), and thioredoxin peroxidase (TPX) levels. Meanwhile, protein carbonyl (PCO) and malondialdehyde (MDA) levels increased in kidney homogenates, increasing the expression of the pro-inflammatory cytokine interleukin-6 (IL-6). This was followed by elevated NF-κB, blood urea nitrogen (BUN), and creatinine serum levels in group III compared with group I. Moreover, histopathological and immunohistochemical examinations demonstrated severe damage to the renal tubular epithelial cells, as well as marked congestion and expressions of caspase-3 and NF-κB. Further, group V showed an improvement in antioxidant activity parameters and reductions in the IL-6, caspase-3, and NF-κB expressions, followed by significant decreases in NF-κB, BUN, and creatinine serum levels. Furthermore, fewer histopathological disturbances were observed compared with untreated group III. Such alterations may be attributed to the antioxidant and anti-inflammatory effects of F. indica. Therefore, our exploration reveals that F. indica is effective in protecting against Cr-induced nephrotoxicity, and it could be applied in the future to human kidney diseases caused by environmental pollutants.
铬(Cr)是一种环境污染物,具有很高的氧化还原电位,可以以多种氧化状态存在,可能导致肾毒性。作为一种潜在的治疗选择,印度梧桐(F. indica)是一种草药,传统上用作治疗疾病的植物药。然而,其保护作用和分子机制尚未得到有效验证。因此,本研究旨在探讨F. indica对cr诱导的瑞士小鼠肾毒性的保护作用。将小鼠分为5组:ⅰ组(阴性对照)、ⅱ组(F. indica)、ⅲ组(重铬酸钾[PDC]处理)、ⅳ组(PDC +生理盐水)和ⅴ组(PDC + F. indica)。我们的研究结果表明,III组表现出超氧化物歧化酶(SOD)、谷胱甘肽s-转移酶(GST)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)和硫氧还蛋白过氧化物酶(TPX)水平的降低。同时,肾脏匀浆中蛋白羰基(PCO)和丙二醛(MDA)水平升高,促炎细胞因子白细胞介素-6 (IL-6)表达升高。与ⅰ组相比,ⅲ组血清中NF-κB、血尿素氮(BUN)和肌酐水平升高。组织病理学和免疫组化检查显示肾小管上皮细胞严重损伤,明显充血,caspase-3和NF-κB表达明显。此外,V组抗氧化活性参数改善,IL-6、caspase-3和NF-κB表达降低,随后NF-κB、BUN和肌酐水平显著降低。此外,与未治疗的III组相比,观察到较少的组织病理学紊乱。这种改变可能是由于印度镰刀菌的抗氧化和抗炎作用。因此,我们的研究表明,F. indica对cr引起的肾毒性具有有效的保护作用,未来可用于环境污染物引起的人类肾脏疾病。
{"title":"<i>Fagonia indica</i> ameliorates chromium-induced nephrotoxicity: Role of antioxidant activity and pro-inflammatory cytokines in <i>in-vivo</i> renoprotection.","authors":"Eman A A Abdallah, Abdullah Almilaibary, Mohamed F El-Refaei","doi":"10.1080/19338244.2023.2185189","DOIUrl":"https://doi.org/10.1080/19338244.2023.2185189","url":null,"abstract":"<p><p>Chromium (Cr) is an environmental pollutant, has high redox potential, and can exist in various oxidation states, possibly leading to nephrotoxicity. As a potential treatment option, <i>Fagonia indica</i> (<i>F. indica</i>) is an herb remedy traditionally used as a phytomedicine to cure ailments. However, efficient validation of its protective effect and molecular mechanisms has not yet been established. As such, this study aims to investigate the protective effect of <i>F. indica</i> against Cr-induced nephrotoxicity in Swiss mice. Mice were divided into five groups: group I (negative control), group II (<i>F. indica</i>), group III (potassium dichromate [PDC]-treated), group IV (PDC + saline), and group V (PDC + <i>F. indica</i>). Our results demonstrate that group III exhibited decreases in superoxide dismutase (SOD), glutathione s-transferases (GST), glutathione peroxidase (GSH-Px), catalase (CAT), and thioredoxin peroxidase (TPX) levels. Meanwhile, protein carbonyl (PCO) and malondialdehyde (MDA) levels increased in kidney homogenates, increasing the expression of the pro-inflammatory cytokine interleukin-6 (IL-6). This was followed by elevated NF-κB, blood urea nitrogen (BUN), and creatinine serum levels in group III compared with group I. Moreover, histopathological and immunohistochemical examinations demonstrated severe damage to the renal tubular epithelial cells, as well as marked congestion and expressions of caspase-3 and NF-κB. Further, group V showed an improvement in antioxidant activity parameters and reductions in the IL-6, caspase-3, and NF-κB expressions, followed by significant decreases in NF-κB, BUN, and creatinine serum levels. Furthermore, fewer histopathological disturbances were observed compared with untreated group III. Such alterations may be attributed to the antioxidant and anti-inflammatory effects of <i>F. indica</i>. Therefore, our exploration reveals that <i>F. indica</i> is effective in protecting against Cr-induced nephrotoxicity, and it could be applied in the future to human kidney diseases caused by environmental pollutants.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 5","pages":"289-303"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9850962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1080/19338244.2023.2209382
Jacqueline Moline
{"title":"Best practices for the care of those exposed after a disaster.","authors":"Jacqueline Moline","doi":"10.1080/19338244.2023.2209382","DOIUrl":"https://doi.org/10.1080/19338244.2023.2209382","url":null,"abstract":"","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":"78 4","pages":"197-198"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9670893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}