U. Erdogdu, Hacı Murat Çaycı, A. Tardu, U. Arslan, Yasemin Üstündağ, O. Erel, H. Demirci, Hasan Çantay
Aim: Helicobacter pylori (HP) infection causes inflammation and oxidative stress at a cellular level. In the present study, we aimed to evaluate the possible relationship between HP and thiol-disulfide homeostasis (TDH), a novel indicator of oxidative stress. Methods: Medical data of a total of 53 patients admitted with persistent dyspepsia and undergoing gastroscopy were evaluated prospectively. The patients were divided into two groups, based on the result of gastric biopsy, as HP-positive (+) and HP-negative (-). Demographic data, ferric-reducing ability of plasma (FRAP), ischemia-modified albumin (IMA), native thiol, total thiol, disulfide, and malondialdehyde (MDA) levels of the patients were recorded and compared between the two groups. Results: The native thiol (451.03 mmol/L vs. 407.03mmol/L, p=0.005) and total thiol (493.20 mmol/L vs. 456.40 mmol/L, p=0.027) levels were significantly higher in the HP (+) group than in the HP (-) group. The disulfide levels and disulfide/native thiol, disulfide/total thiol and native thiol/total thiol ratios were similar between the HP (+) and HP (-) groups. Although the FRAP was lower in the HP (+) group than in the HP (-) group, this difference was not statistically significant (0.94 mmol/L vs. 1.10 mmol/L). No statistically significant difference was found between the groups in the IMA and MDA levels. Conclusion: In this study, oxidative status of HP patients was evaluated in several different methods. Among them, only elevated native thiol and total thiol levels were found in HP-induced gastritis. There is a need for further studies involving a larger number of patients and a subgroup analysis to examine whether elevated serum thiol-disulfide levels in HP infection suggest an antioxidant or pro-oxidant status.
目的:幽门螺杆菌(HP)感染引起细胞水平的炎症和氧化应激。在本研究中，我们旨在评估HP与硫-二硫稳态(TDH)之间的可能关系，TDH是一种新的氧化应激指标。方法:对53例持续性消化不良患者行胃镜检查的医疗资料进行前瞻性评价。根据胃活检结果将患者分为hp阳性(+)和hp阴性(-)两组。记录两组患者的人口统计学数据、血浆铁还原能力(FRAP)、缺血修饰白蛋白(IMA)、天然硫醇、总硫醇、二硫化物和丙二醛(MDA)水平并进行比较。结果:HP(+)组的天然硫醇(451.03 mmol/L vs. 407.03mmol/L, p=0.005)和总硫醇(493.20 mmol/L vs. 456.40 mmol/L, p=0.027)水平显著高于HP(-)组。HP(+)组和HP(-)组的二硫化物含量、二硫化物/天然硫醇、二硫化物/总硫醇和天然硫醇/总硫醇比值相似。虽然HP(+)组的FRAP低于HP(-)组，但差异无统计学意义(0.94 mmol/L vs. 1.10 mmol/L)。两组间IMA和MDA水平差异无统计学意义。结论:在本研究中，采用几种不同的方法评估HP患者的氧化状态。其中，仅在hp诱导的胃炎中发现天然硫醇和总硫醇水平升高。有必要对更多的患者进行进一步的研究，并进行亚组分析，以检验HP感染中血清硫醇二硫水平升高是否提示抗氧化或促氧化状态。
{"title":"Relationship between Helicobacter pylori and thiol-disulfide homeostasis: A prospective observational study","authors":"U. Erdogdu, Hacı Murat Çaycı, A. Tardu, U. Arslan, Yasemin Üstündağ, O. Erel, H. Demirci, Hasan Çantay","doi":"10.25000/acem.635688","DOIUrl":"https://doi.org/10.25000/acem.635688","url":null,"abstract":"Aim: Helicobacter pylori (HP) infection causes inflammation and oxidative stress at a cellular level. In the present study, we aimed to evaluate the possible relationship between HP and thiol-disulfide homeostasis (TDH), a novel indicator of oxidative stress. Methods: Medical data of a total of 53 patients admitted with persistent dyspepsia and undergoing gastroscopy were evaluated prospectively. The patients were divided into two groups, based on the result of gastric biopsy, as HP-positive (+) and HP-negative (-). Demographic data, ferric-reducing ability of plasma (FRAP), ischemia-modified albumin (IMA), native thiol, total thiol, disulfide, and malondialdehyde (MDA) levels of the patients were recorded and compared between the two groups. Results: The native thiol (451.03 mmol/L vs. 407.03mmol/L, p=0.005) and total thiol (493.20 mmol/L vs. 456.40 mmol/L, p=0.027) levels were significantly higher in the HP (+) group than in the HP (-) group. The disulfide levels and disulfide/native thiol, disulfide/total thiol and native thiol/total thiol ratios were similar between the HP (+) and HP (-) groups. Although the FRAP was lower in the HP (+) group than in the HP (-) group, this difference was not statistically significant (0.94 mmol/L vs. 1.10 mmol/L). No statistically significant difference was found between the groups in the IMA and MDA levels. Conclusion: In this study, oxidative status of HP patients was evaluated in several different methods. Among them, only elevated native thiol and total thiol levels were found in HP-induced gastritis. There is a need for further studies involving a larger number of patients and a subgroup analysis to examine whether elevated serum thiol-disulfide levels in HP infection suggest an antioxidant or pro-oxidant status.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88197538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Inflammation has a significant role in the pathogenesis of atherosclerosis and allergic inflammation has also an important impact on atherosclerosis progression. In this study, we investigated whether the serum IgE levels are associated with coronary artery disease (CAD) and SYNTAX score as a parameter for severity of the disease. Methods : A total of 171 patients who were planned coronary angiography were recruited consecutively into this study. The patients who had a diagnosis of asthma, autoimmune diseases, allergic dermatitis, history of allergic diseases, parasitic infections, malignancy, severe renal failure (estimated glomerular filtration rate <30 mL/min), chronic hepatic disease, rheumatic and valvular heart diseases were excluded from the study. The patients were divided into two groups according to the presence of CAD as called CAD and non-CAD groups. CAD was diagnosed according to the presence of more than 50% stenosis at least in one main coronary artery. Two expert cardiologists who were blinded to the patients’ clinical and laboratory data reviewed the coronary angiography and evaluated the coronary atherosclerotic lesion severity independently. The SYNTAX score is calculated using the algorithm on the baseline diagnostic angiogram. Serum samples for determining total serum levels of IgE were collected from the patients were at the admission just prior to coronary angiography. Results: Based on the coronary angiography, 88 patients (51.5%) were in the non-CAD and 83 patients (48.5%) were in the CAD group. CAD patients tend to be older (61.9±11.6 years vs 56.7±9.7years, p=0.002) and male (67.5% vs.47.7%, p=0.009) with a higher prevalence of hypertension (80.7% vs 63.6%, p=0.013), and hyperlipidemia (63.9% vs 28.4%, p<0.001) compared to non-CAD patients. The serum IgE levels were significantly higher in the CAD group than those in the non-CAD group (99.05 IU/ml (51-192) vs. 24.25 IU/ml (13.8-55), p<0.001). By multivariate logistic regression analysis, serum IgE levels were found as an independent predictor for CAD (OR 1.003; 95% CI 1.000–1.005; p=0.041). In addition, there was a positive moderate correlation between SYNTAX score and Ig E levels (r:0,483, p<0.001). Conclusion : In this trial, we showed that the serum IgE levels are positively associated with the presence of CAD even after adjusting for traditional cardiovascular risk factors. Furthermore, serum IgE levels are correlated with the SYNTAX score and the complexity of coronary artery disease.
目的:炎症在动脉粥样硬化的发病机制中起重要作用，变应性炎症对动脉粥样硬化的进展也有重要影响。在这项研究中，我们调查了血清IgE水平是否与冠状动脉疾病(CAD)和SYNTAX评分相关，作为疾病严重程度的参数。方法:连续招募171例计划行冠状动脉造影的患者。诊断为哮喘、自身免疫性疾病、过敏性皮炎、过敏性疾病史、寄生虫感染、恶性肿瘤、严重肾功能衰竭(估计肾小球滤过率<30 mL/min)、慢性肝病、风湿性和瓣膜性心脏病的患者被排除在研究之外。根据有无CAD分为两组，分别称为CAD组和非CAD组。冠心病的诊断依据是至少一条主冠状动脉狭窄超过50%。两位不了解患者临床和实验室数据的心脏病专家独立审查了冠状动脉造影并评估了冠状动脉粥样硬化病变的严重程度。SYNTAX评分是使用基线诊断血管造影的算法计算的。用于测定血清总IgE水平的血清样本采集于患者入院前冠状动脉造影。结果:冠状动脉造影显示，非CAD组88例(51.5%)，CAD组83例(48.5%)。冠心病患者以老年(61.9±11.6岁vs 56.7±9.7岁，p=0.002)和男性(67.5% vs.47.7%， p=0.009)为主，高血压(80.7% vs. 63.6%， p=0.013)和高脂血症(63.9% vs. 28.4%， p<0.001)的患病率高于非冠心病患者。冠心病组血清IgE水平显著高于非冠心病组(99.05 IU/ml (51-192) vs. 24.25 IU/ml (13.8-55)， p<0.001)。多因素logistic回归分析发现血清IgE水平是CAD的独立预测因子(OR 1.003;95% ci 1.000-1.005;p = 0.041)。此外，SYNTAX评分与Ig E水平呈正相关(r:0,483, p<0.001)。结论:在这项试验中，我们发现血清IgE水平与冠心病的存在呈正相关，即使在调整了传统的心血管危险因素之后。此外，血清IgE水平与SYNTAX评分和冠状动脉疾病的复杂性相关。
{"title":"Relation of serum Immunoglobulin E level with coronary artery disease and SYNTAX score","authors":"A. Çimen, D. Öztürk","doi":"10.25000/acem.692829","DOIUrl":"https://doi.org/10.25000/acem.692829","url":null,"abstract":"Aim: Inflammation has a significant role in the pathogenesis of atherosclerosis and allergic inflammation has also an important impact on atherosclerosis progression. In this study, we investigated whether the serum IgE levels are associated with coronary artery disease (CAD) and SYNTAX score as a parameter for severity of the disease. Methods : A total of 171 patients who were planned coronary angiography were recruited consecutively into this study. The patients who had a diagnosis of asthma, autoimmune diseases, allergic dermatitis, history of allergic diseases, parasitic infections, malignancy, severe renal failure (estimated glomerular filtration rate <30 mL/min), chronic hepatic disease, rheumatic and valvular heart diseases were excluded from the study. The patients were divided into two groups according to the presence of CAD as called CAD and non-CAD groups. CAD was diagnosed according to the presence of more than 50% stenosis at least in one main coronary artery. Two expert cardiologists who were blinded to the patients’ clinical and laboratory data reviewed the coronary angiography and evaluated the coronary atherosclerotic lesion severity independently. The SYNTAX score is calculated using the algorithm on the baseline diagnostic angiogram. Serum samples for determining total serum levels of IgE were collected from the patients were at the admission just prior to coronary angiography. Results: Based on the coronary angiography, 88 patients (51.5%) were in the non-CAD and 83 patients (48.5%) were in the CAD group. CAD patients tend to be older (61.9±11.6 years vs 56.7±9.7years, p=0.002) and male (67.5% vs.47.7%, p=0.009) with a higher prevalence of hypertension (80.7% vs 63.6%, p=0.013), and hyperlipidemia (63.9% vs 28.4%, p<0.001) compared to non-CAD patients. The serum IgE levels were significantly higher in the CAD group than those in the non-CAD group (99.05 IU/ml (51-192) vs. 24.25 IU/ml (13.8-55), p<0.001). By multivariate logistic regression analysis, serum IgE levels were found as an independent predictor for CAD (OR 1.003; 95% CI 1.000–1.005; p=0.041). In addition, there was a positive moderate correlation between SYNTAX score and Ig E levels (r:0,483, p<0.001). Conclusion : In this trial, we showed that the serum IgE levels are positively associated with the presence of CAD even after adjusting for traditional cardiovascular risk factors. Furthermore, serum IgE levels are correlated with the SYNTAX score and the complexity of coronary artery disease.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78588155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Granuler hucreli tumor (GHT), hemen hemen vucudun her bolgesinde ortaya cikabilen bir tumordur. Vakalarin yaklasik % 5 ila 15'i memede gorulur ve aksillada nispeten nadir ortaya cikarlar. Granuler hucreli tumorlerin % 1-2'si maligndir. Meme GHT'lerinin klinik semptomlari ve goruntuleme incelemeleri spesifik degildir ve malign tumorlerle kolayca karisabilir. Cogu iyi huyludur ve bildirilen malign vakalar nadirdir. Aksiller bolgede yaklasik 2 yildir palpabl kitlesi olan ve granuler hucreli tumor tanisi alan 59 yasinda bir erkek hastayi sunuyoruz. Palpabl kitlesi yaklasik 15 mm capindaydi ve klinik olarak malignite suphesi vardi. Kitlenin kalin igne biyopsisi granuler hucreli tumor ozellikleri gosterdi ve cerrahi eksizyon yapildi. Tumorun erken tanisi ve tam rezeksiyonu en iyi tedavi yontemi olmaya devam etmektedir.
{"title":"GRANULAR CELL TUMOR PRESENTING AS AN AXILLARY MASS: A CASE REPORT","authors":"B. Citgez, Banu Yigit, S. Yetkin, M. Mihmanlı","doi":"10.25000/acem.645475","DOIUrl":"https://doi.org/10.25000/acem.645475","url":null,"abstract":"Granuler hucreli tumor (GHT), hemen hemen vucudun her bolgesinde ortaya cikabilen bir tumordur. Vakalarin yaklasik % 5 ila 15'i memede gorulur ve aksillada nispeten nadir ortaya cikarlar. Granuler hucreli tumorlerin % 1-2'si maligndir. Meme GHT'lerinin klinik semptomlari ve goruntuleme incelemeleri spesifik degildir ve malign tumorlerle kolayca karisabilir. Cogu iyi huyludur ve bildirilen malign vakalar nadirdir. Aksiller bolgede yaklasik 2 yildir palpabl kitlesi olan ve granuler hucreli tumor tanisi alan 59 yasinda bir erkek hastayi sunuyoruz. Palpabl kitlesi yaklasik 15 mm capindaydi ve klinik olarak malignite suphesi vardi. Kitlenin kalin igne biyopsisi granuler hucreli tumor ozellikleri gosterdi ve cerrahi eksizyon yapildi. Tumorun erken tanisi ve tam rezeksiyonu en iyi tedavi yontemi olmaya devam etmektedir.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89771767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The present study aimed to compare trochlear morphology observed on magnetic resonance imaging (MRI) between patients with lateral patellar cartilage defect and age-matched-pair control patients without cartilage defect. Methods: A total of 75 patients with MRI-verified grade 3/4 lateral patellar cartilage defect were compared with matched-pair control patients without cartilage defects of the patellofemoral joints. Axial sequences were used to detect and evaluate patellar cartilage defects. Trochlear morphology was assessed on the basis of lateral trochlear inclination (LTI), medial trochlear inclination (MTI), sulcus angle (SA), trochlear facet asymmetry (FA), and trochlear width (TW) on axial MR images. Results: SA was higher for both sexes in the cartilage defect group than in the control group (p 0.05). FA for both sexes was significantly lower in the cartilage defect group than in the control group (p < 0.05). TW was significantly higher in the cartilage defect group than in the control group (p < 0.05). Finally, TW of females in the cartilage defect group was significantly higher than that of females in the control group (p < 0.05). Conclusion: Flattened lateral trochlea is a risk factor for structural damage to the cartilage of the lateral patellofemoral joint, particularly in females.
{"title":"Relationship between trochlear morphology and lateral patellar cartilage defect using MR Imaging","authors":"S. Duran, E. Günaydın","doi":"10.25000/acem.612100","DOIUrl":"https://doi.org/10.25000/acem.612100","url":null,"abstract":"Aim: The present study aimed to compare trochlear morphology observed on magnetic resonance imaging (MRI) between patients with lateral patellar cartilage defect and age-matched-pair control patients without cartilage defect. Methods: A total of 75 patients with MRI-verified grade 3/4 lateral patellar cartilage defect were compared with matched-pair control patients without cartilage defects of the patellofemoral joints. Axial sequences were used to detect and evaluate patellar cartilage defects. Trochlear morphology was assessed on the basis of lateral trochlear inclination (LTI), medial trochlear inclination (MTI), sulcus angle (SA), trochlear facet asymmetry (FA), and trochlear width (TW) on axial MR images. Results: SA was higher for both sexes in the cartilage defect group than in the control group (p 0.05). FA for both sexes was significantly lower in the cartilage defect group than in the control group (p < 0.05). TW was significantly higher in the cartilage defect group than in the control group (p < 0.05). Finally, TW of females in the cartilage defect group was significantly higher than that of females in the control group (p < 0.05). Conclusion: Flattened lateral trochlea is a risk factor for structural damage to the cartilage of the lateral patellofemoral joint, particularly in females.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76622262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The aim of this study is, to compare the posterior malleolar fragment (PMF) sizing between lateral ankle radiography measurement and computer assistted 3D modelling (CA3DM) methods Methods: Fifty-one patients between january 2015 and november 2018 with posterior malleolar fractured were included in this study. The rate of PMF to the articular surface at the distal end of the tibia was calculated by two different imaging methods by two surgeons. According to posterior fragment size, patients were separated into two groups. Group 1 was consisted of posterior fragment size smaller than 15% and group 2 was bigger than 15% due to CA3DM. Results: The interobserver correlation (IOC) between two observers and CA3DM was 44.3%. Also the IOC between first observer and CA3DM was 35.7% (p 0.05), second observer and CA3DM was 51.6% (p 0.05), first and CA3DM was 18.6% (p>0.05), second observer and CA3DM was 7.1% (p>0.05) and two observers was 49% (p<0.05). Conclusion: Our study shows that posterior malleolar fragment size measuring on plain radiography is not a safe method for bigger fragments and CA3DM method may be a more reliable to assess correct fragment size and also to analyze fracture morphology. But for fragments ≤15% CA3DM and plain radiographic measures are not statistically different.
{"title":"Comparison of two plain radiographic and 3D-based measurement methods for posterior malleolar fragment size in trimalleol ankle fractures","authors":"G. Altun, H. Reis, B. Bayram, G. Saka","doi":"10.25000/acem.641188","DOIUrl":"https://doi.org/10.25000/acem.641188","url":null,"abstract":"Aim: The aim of this study is, to compare the posterior malleolar fragment (PMF) sizing between lateral ankle radiography measurement and computer assistted 3D modelling (CA3DM) methods Methods: Fifty-one patients between january 2015 and november 2018 with posterior malleolar fractured were included in this study. The rate of PMF to the articular surface at the distal end of the tibia was calculated by two different imaging methods by two surgeons. According to posterior fragment size, patients were separated into two groups. Group 1 was consisted of posterior fragment size smaller than 15% and group 2 was bigger than 15% due to CA3DM. Results: The interobserver correlation (IOC) between two observers and CA3DM was 44.3%. Also the IOC between first observer and CA3DM was 35.7% (p 0.05), second observer and CA3DM was 51.6% (p 0.05), first and CA3DM was 18.6% (p>0.05), second observer and CA3DM was 7.1% (p>0.05) and two observers was 49% (p<0.05). Conclusion: Our study shows that posterior malleolar fragment size measuring on plain radiography is not a safe method for bigger fragments and CA3DM method may be a more reliable to assess correct fragment size and also to analyze fracture morphology. But for fragments ≤15% CA3DM and plain radiographic measures are not statistically different.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86153377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Yıldız, Adile Merve Baki, C. Başaran-Küçükgergin, P. Vural, S. Doǧru-Abbasoǧlu, M. Uysal
Amac: Asetaldehit (AA), alkol metabolizmasinin ana urunlerinden biridir. AA'e maruz kalma bircok diyet urununun yenmesi, sigara dumani/otomobil egzozlarinin solunmasi veya kozmetik urunlerle temas yoluyla olusabilir. AA birikimi oksidatif strese neden olur. Bu calismanin amaci kronik AA'e maruz kalan sicanlarda prooksidant/antioksidan durumunu arastirmak ve N-asetil sistein (NAC) ve taurinin (TAU) proksidant/antioksidan dengesi uzerindeki etkilerini degerlendirmektir. Yontemler: Sprague Dawley sicanlar asagidaki gruplara ayrildi (n = 8; her biri): Kontrol, AA, AA+NAC, AA+TAU. Karaciger ve beyin dokularinda reaktif oksijen turleri (ROS), dien konjugatlari (DC), malondialdehit (MDA), protein karbonil (PC), ferrik indirgeyici antioksidan guc (FRAP) ve glutatyon (GSH) duzeyleri ve ayrica superoksit dismutaz (SOD) ve glutatyon peroksidaz (GSH-Px) aktiviteleri incelendi. Bulgular: Icme suyu ile AA uygulanan sicanlarin karaciger ve beyin dokularinda prooksidan bir durum olustugu saptandi. NAC uygulamasi her iki dokuda AA’e bagli prooksidan durumu azaltti. TAU incelenen dokularda ROS olusumunu azaltmasina ragmen, MDA ve PC duzeyleri degismedi. NAC and TAU AA uygulanan sicanlarin karaciger ve beyinlerinde GSH duzeylerini arttirdi. Sonuc: Kronik AA uygulamasinin proksidant bir durum yarattigini, NAC/TAU uygulamalarinin AA ile uyarilan oksidatif stresin baskilamada yararli olabildigi gorulmektedir.
{"title":"Protective effects of N-acetylcysteine and taurine on oxidative stress induced by chronic acetaldehyde administration in rat liver and brain tissues","authors":"Z. Yıldız, Adile Merve Baki, C. Başaran-Küçükgergin, P. Vural, S. Doǧru-Abbasoǧlu, M. Uysal","doi":"10.25000/acem.579968","DOIUrl":"https://doi.org/10.25000/acem.579968","url":null,"abstract":"Amac: Asetaldehit (AA), alkol metabolizmasinin ana urunlerinden biridir. AA'e maruz kalma bircok diyet urununun yenmesi, sigara dumani/otomobil egzozlarinin solunmasi veya kozmetik urunlerle temas yoluyla olusabilir. AA birikimi oksidatif strese neden olur. Bu calismanin amaci kronik AA'e maruz kalan sicanlarda prooksidant/antioksidan durumunu arastirmak ve N-asetil sistein (NAC) ve taurinin (TAU) proksidant/antioksidan dengesi uzerindeki etkilerini degerlendirmektir. Yontemler: Sprague Dawley sicanlar asagidaki gruplara ayrildi (n = 8; her biri): Kontrol, AA, AA+NAC, AA+TAU. Karaciger ve beyin dokularinda reaktif oksijen turleri (ROS), dien konjugatlari (DC), malondialdehit (MDA), protein karbonil (PC), ferrik indirgeyici antioksidan guc (FRAP) ve glutatyon (GSH) duzeyleri ve ayrica superoksit dismutaz (SOD) ve glutatyon peroksidaz (GSH-Px) aktiviteleri incelendi. Bulgular: Icme suyu ile AA uygulanan sicanlarin karaciger ve beyin dokularinda prooksidan bir durum olustugu saptandi. NAC uygulamasi her iki dokuda AA’e bagli prooksidan durumu azaltti. TAU incelenen dokularda ROS olusumunu azaltmasina ragmen, MDA ve PC duzeyleri degismedi. NAC and TAU AA uygulanan sicanlarin karaciger ve beyinlerinde GSH duzeylerini arttirdi. Sonuc: Kronik AA uygulamasinin proksidant bir durum yarattigini, NAC/TAU uygulamalarinin AA ile uyarilan oksidatif stresin baskilamada yararli olabildigi gorulmektedir.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89309323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amac: Pilonidal sinus sik karsilasilan bir hastaliktir. Cerrahi sonrasi agri, hareket kisitliligi, gunluk ise donus ve rekurrens onemli sorunlardir. Bu calismanin amaci, pilonidal sinus hastaligi nedeniyle sinusotomi yontemi ile ameliyat edilen hastalarda ameliyat sonrasi sonuclarini degerlendirmektir. Yontemler: Bu calisma, 2016 ve 2019 yillari arasinda pilonidal sinus hastaligi nedeniyle sinusotomi metodu ile tedavi edilen hastalarda retrospektif olarak yapildi. Sinusotomi yapilan 83 hastanin verileri hastane kayitlari ile gozden gecirildi. Yas, cinsiyet, semptom suresi, pit sayisi, ameliyat suresi, ameliyat sonrasi 2.gun VAS agri skoru ve rekurrens oranlari incelendi. Bulgular: Hastalarin 78’i (94%) erkek, 5’i (6%) kadindi. Ortalama yas 26,6 (15-42) yil ve ortalama semptom suresi 4.6 (1-20) aydi. Ortalama pit sayisi 3.2 (1-13), ortalama ameliyat suresi 9.1(5-21) dakika, 2.gun ortalama VAS agri skoru 0.6 (0-2) idi. Ortalama iyilesme suresi 4.01 (2-11) haftaydi. 2 hastada (2,4%) rekurrens izlendi. Sonuc: Sinusotomi, pilonidal sinus cerrrahisinde kullanilabilecek guvenli ve etkin bir minimal invaziv yontem olabilir. Bununla beraber, diger tekniklerle karsilastirmali prospektif calismalara ihtiyac vardir.
{"title":"An effective minimal invasive method in pilonidal sinus surgery: Sinusotomy","authors":"Önder Karabay","doi":"10.25000/acem.633313","DOIUrl":"https://doi.org/10.25000/acem.633313","url":null,"abstract":"Amac: Pilonidal sinus sik karsilasilan bir hastaliktir. Cerrahi sonrasi agri, hareket kisitliligi, gunluk ise donus ve rekurrens onemli sorunlardir. Bu calismanin amaci, pilonidal sinus hastaligi nedeniyle sinusotomi yontemi ile ameliyat edilen hastalarda ameliyat sonrasi sonuclarini degerlendirmektir. Yontemler: Bu calisma, 2016 ve 2019 yillari arasinda pilonidal sinus hastaligi nedeniyle sinusotomi metodu ile tedavi edilen hastalarda retrospektif olarak yapildi. Sinusotomi yapilan 83 hastanin verileri hastane kayitlari ile gozden gecirildi. Yas, cinsiyet, semptom suresi, pit sayisi, ameliyat suresi, ameliyat sonrasi 2.gun VAS agri skoru ve rekurrens oranlari incelendi. Bulgular: Hastalarin 78’i (94%) erkek, 5’i (6%) kadindi. Ortalama yas 26,6 (15-42) yil ve ortalama semptom suresi 4.6 (1-20) aydi. Ortalama pit sayisi 3.2 (1-13), ortalama ameliyat suresi 9.1(5-21) dakika, 2.gun ortalama VAS agri skoru 0.6 (0-2) idi. Ortalama iyilesme suresi 4.01 (2-11) haftaydi. 2 hastada (2,4%) rekurrens izlendi. Sonuc: Sinusotomi, pilonidal sinus cerrrahisinde kullanilabilecek guvenli ve etkin bir minimal invaziv yontem olabilir. Bununla beraber, diger tekniklerle karsilastirmali prospektif calismalara ihtiyac vardir.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73974613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. S. Söylemez, Murat Demiroğlu, Davut Aydın, F. Akpinar, Bülent Kiliç, O. K. Unal, K. Ozkan
Amac: Parcali ve deplase kiriklarin cerrahi rekonstruksiyonu sirasinda opere edilen kemigin uygun boyunun tahmin edilebilmesi icin bu kemik boyu ile komsu diger bir kemigin matematiksel olarak boy oraninin kullanilmasi oldukca kullanislidir. Bu calismada parcali klavikula kiriklari cerrahi tedavisi sirasinda kullanilmak uzere, klavikula ve ulna kemikleri arasinda matematiksel olarak anlamli bir boy orani olup olmadiginin arastirilmasi amaclanmistir. Yontemler: Nisan-Haziran 2019 donemi icerisinde, ortopedi ve travmatoloji poliklinigimizde gorulen ust ekstremiteleri saglikli 130 hasta (76 erkek, 54 kadin) calismaya dahil edildi. Butun hastalarin sag ve sol ulna ve klavikulalari birbirinin olcumlerine kor 2 yazar tarafindan, ayni yontemler kullanilarak olculdu. Bulgular: Toplamda ortalama yas 32.2 yil idi. Ayni taraf ulna ve klavikula boylari arasinda anlamli bir oran oldugu saptandi (p=0.001). Ayni zamanda sag ve sol klavikula boylari arasinda anlamli uzunluk farki bulundugu goruldu. Sol klavikula, erkeklerde 9.00 ± 2.16 mm ve kadinlarda 7.13 ± 2.03 mm sag klavikuladan daha uzun idi (p=0.001). Ancak her iki grupta da sag ve sol ulna boylari arasinda anlamli bir fark saptanmadi (0.84 ± 1.033 mm erkeklerde ve 0.52 ± 0.818 mm kadinlarda). Sonuclar: Hem kadin, hem de erkeklerde her iki tarafta klavikula ve ulna kemikleri arasinda matematiksel olarak anlamli bir oran var oldugu ortaya kondu. Ancak bu oran her iki cinsiyet icin farkli idi. Biz bu calismanin sonucuna dayanarak, parcali klavikula kiriklarinin plak ve ozellikle civi ile cerrahi tedavisi sirasinda, ortaya konan bu orantisal formullerin uygun kemik boyunun hesaplanarak saglanmasi icin kullanilabilecegini dusunmekteyiz.
{"title":"Is there a relationship between the lengths of the ipsilateral clavicle and the ulna? An anthropometric and statistical study","authors":"M. S. Söylemez, Murat Demiroğlu, Davut Aydın, F. Akpinar, Bülent Kiliç, O. K. Unal, K. Ozkan","doi":"10.25000/ACEM.571566","DOIUrl":"https://doi.org/10.25000/ACEM.571566","url":null,"abstract":"Amac: Parcali ve deplase kiriklarin cerrahi rekonstruksiyonu sirasinda opere edilen kemigin uygun boyunun tahmin edilebilmesi icin bu kemik boyu ile komsu diger bir kemigin matematiksel olarak boy oraninin kullanilmasi oldukca kullanislidir. Bu calismada parcali klavikula kiriklari cerrahi tedavisi sirasinda kullanilmak uzere, klavikula ve ulna kemikleri arasinda matematiksel olarak anlamli bir boy orani olup olmadiginin arastirilmasi amaclanmistir. Yontemler: Nisan-Haziran 2019 donemi icerisinde, ortopedi ve travmatoloji poliklinigimizde gorulen ust ekstremiteleri saglikli 130 hasta (76 erkek, 54 kadin) calismaya dahil edildi. Butun hastalarin sag ve sol ulna ve klavikulalari birbirinin olcumlerine kor 2 yazar tarafindan, ayni yontemler kullanilarak olculdu. Bulgular: Toplamda ortalama yas 32.2 yil idi. Ayni taraf ulna ve klavikula boylari arasinda anlamli bir oran oldugu saptandi (p=0.001). Ayni zamanda sag ve sol klavikula boylari arasinda anlamli uzunluk farki bulundugu goruldu. Sol klavikula, erkeklerde 9.00 ± 2.16 mm ve kadinlarda 7.13 ± 2.03 mm sag klavikuladan daha uzun idi (p=0.001). Ancak her iki grupta da sag ve sol ulna boylari arasinda anlamli bir fark saptanmadi (0.84 ± 1.033 mm erkeklerde ve 0.52 ± 0.818 mm kadinlarda). Sonuclar: Hem kadin, hem de erkeklerde her iki tarafta klavikula ve ulna kemikleri arasinda matematiksel olarak anlamli bir oran var oldugu ortaya kondu. Ancak bu oran her iki cinsiyet icin farkli idi. Biz bu calismanin sonucuna dayanarak, parcali klavikula kiriklarinin plak ve ozellikle civi ile cerrahi tedavisi sirasinda, ortaya konan bu orantisal formullerin uygun kemik boyunun hesaplanarak saglanmasi icin kullanilabilecegini dusunmekteyiz.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77093242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Çoşkun Şimşir, B. Coşkun, Buğra Çoşkun, A. Erşahin, T. Ecemis
Amac: Kadinlarda en sik gorulen vajinal enfeksiyon olan bakteriyel vajinozun ve tedavisinin cinsel fonksiyonlara olan etkilerini arastirmak. Yontemler: Ocak 2018-Ocak 2019 tarihleri arasinda jinekoloji poliklinigimizde kultur sonuclarina dayanarak bakteri vajinoz tanisi alan hastalar bu gozlemsel anket calismasina dahil edildi. Eslik eden bir hastaligi olan ve muhtemelen cinsel islev bozuklugu olan hastalar ile bakteriyel vajinoz disindaki vajinit etiyolojisi olanlar calisma disi birakildi. Hastalara bakteri vajinoz teshisi sirasinda ve tedaviden 1 ay sonra Kadin Cinsel Islev Indeksi (FSFI) anketi uygulandi. Bulgular: Calisma kriterlerini karsilayan 75 hasta calismaya dahil edildi. FSFI skorlarinin karsilastirilmasinda tedavi sonrasi orgasm, agri skorlari ve toplam FSFI skorlarinda istatistiksel olarak anlamli duzelme saptandi (p 0,05). Sonuc: Bakteriyel vajinozlu hastalarda cinsel islev bozuklugunun daha yaygin oldugu ve tedaviyle bazi cinsel islevlerde duzelme oldugu tespit edildi.
{"title":"Effects of bacterial vaginosis and its treatment on sexual functions: A cross-sectional questionnaire study","authors":"Çoşkun Şimşir, B. Coşkun, Buğra Çoşkun, A. Erşahin, T. Ecemis","doi":"10.25000/ACEM.585436","DOIUrl":"https://doi.org/10.25000/ACEM.585436","url":null,"abstract":"Amac: Kadinlarda en sik gorulen vajinal enfeksiyon olan bakteriyel vajinozun ve tedavisinin cinsel fonksiyonlara olan etkilerini arastirmak. Yontemler: Ocak 2018-Ocak 2019 tarihleri arasinda jinekoloji poliklinigimizde kultur sonuclarina dayanarak bakteri vajinoz tanisi alan hastalar bu gozlemsel anket calismasina dahil edildi. Eslik eden bir hastaligi olan ve muhtemelen cinsel islev bozuklugu olan hastalar ile bakteriyel vajinoz disindaki vajinit etiyolojisi olanlar calisma disi birakildi. Hastalara bakteri vajinoz teshisi sirasinda ve tedaviden 1 ay sonra Kadin Cinsel Islev Indeksi (FSFI) anketi uygulandi. Bulgular: Calisma kriterlerini karsilayan 75 hasta calismaya dahil edildi. FSFI skorlarinin karsilastirilmasinda tedavi sonrasi orgasm, agri skorlari ve toplam FSFI skorlarinda istatistiksel olarak anlamli duzelme saptandi (p 0,05). Sonuc: Bakteriyel vajinozlu hastalarda cinsel islev bozuklugunun daha yaygin oldugu ve tedaviyle bazi cinsel islevlerde duzelme oldugu tespit edildi.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85358509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amac: Calismamizda retrospektif olarak otolog zenginlestirilmis serum (OZS) tedavisinin osteoartritteki etkisinin bilateral diz enjeksiyonu ile degerlendirilmesi amaclanmistir. Yontemler: Calismamiza yas ortalamasi 57.6 ± 8.21 yil (41-70) olan 33 hasta (19 kadin, 14 erkek) 66 diz dahil edilmistir. Calismamiza katilan hastalarin diz osteoartritleri Kellgren-Lawrence siniflamasina gore bilateral olarak evre 2-3 idi. Sekonder artrit, enflamatuar eklem hastaliklari, klinik olarak ilgili hematolojik veya anormal klinik kimya degerleri, eklem instabilitesi, son 6 ay icerisinde eklem ici kortikosteroid enjeksiyonu uygulanan, diabetes mellitus oykusu, 30 kg/m 2 'dan buyuk vucut kitle indeksi mevcut olan hastalar calismadan dislandi. Her iki diz arasindaki VAS farkliligi 2 puandan fazla olan hastalar calismadan cikarildi. Uc hafta boyunca haftada iki kez toplamda 6 kez her iki diz eklem icine OZS enjekte edildi. Hastalar VAS agri skorlamasi (hic agri olmamasi 0 olarak ve maksimum agri 10 olarak derecelendirildi), Diz Yaralanmasi ve Osteoartirit Skalasi (DYOS) (puanlama 0 ile 100 arasinda degismektedir. 0 anormal derecede yuksek diz problemleri gosterirken, 100 problemsiz saglikli bir diz gostermektedir) ve Diz Cemiyeti Skorlamasi (DCS) (Maksimum 100 puan olan skala agriya 50, stabiliteye 25 ve eklem hareket acikligina 25 puan atanir) skalalari ile ilk enjeksiyon oncesi ve son enjeksiyondan 1 yil sonra degerlendirildi. Bulgular: Hastalarin tedavi oncesi ve 1. yil takip VAS degerleri sirasi ile 7.36±0.93 (aralik: 5-9) ve 3.27±1.23 (aralik: 1-6) idi. OZS tedavisi VAS skorunda istatistiksel olarak anlamli dusme gostermistir (p<0.01). Hastalarin tedavi oncesi ve 1. yil takip DYOS toplam degerleri sirasi ile 42.39±13.38 (aralik: 21-65) ve 72.36±8.81 (aralik: 54-92) idi. Hastalarin DYOS total skorunda istatistiksel olarak anlamli yukselme saptanmistir (p<0.01). Hastalarin tedavi oncesi ve 1. yil takip DCS degerleri sirasi ile 42.79±10.26 (aralik: 14-61) ve 70.61±9.32 (aralik: 49-84) idi. Hastalarin DCS degerlerinde istatistiksel olarak anlamli yukselme saptanmistir (p<0.01). Sonuc: Agrili diz osteoartriti olan hastalarda inra-artikuler OZS kullanimi agri siddeti, DYS, DYOS ve DCS skorlari acisindan anlamli iyilesmelere yol acmaktadir. Bu bulgular isiginda, OZS tedavisi osteoartritte etkili ve guvenli bir alternatif bir tedavi yontemi olarak degerlendirilebilir.
{"title":"Evaluation of the autologous conditioned serum in the treatment of osteoarthritis","authors":"B. E. Kılınç, Y. Oc","doi":"10.25000/ACEM.569936","DOIUrl":"https://doi.org/10.25000/ACEM.569936","url":null,"abstract":"Amac: Calismamizda retrospektif olarak otolog zenginlestirilmis serum (OZS) tedavisinin osteoartritteki etkisinin bilateral diz enjeksiyonu ile degerlendirilmesi amaclanmistir. Yontemler: Calismamiza yas ortalamasi 57.6 ± 8.21 yil (41-70) olan 33 hasta (19 kadin, 14 erkek) 66 diz dahil edilmistir. Calismamiza katilan hastalarin diz osteoartritleri Kellgren-Lawrence siniflamasina gore bilateral olarak evre 2-3 idi. Sekonder artrit, enflamatuar eklem hastaliklari, klinik olarak ilgili hematolojik veya anormal klinik kimya degerleri, eklem instabilitesi, son 6 ay icerisinde eklem ici kortikosteroid enjeksiyonu uygulanan, diabetes mellitus oykusu, 30 kg/m 2 'dan buyuk vucut kitle indeksi mevcut olan hastalar calismadan dislandi. Her iki diz arasindaki VAS farkliligi 2 puandan fazla olan hastalar calismadan cikarildi. Uc hafta boyunca haftada iki kez toplamda 6 kez her iki diz eklem icine OZS enjekte edildi. Hastalar VAS agri skorlamasi (hic agri olmamasi 0 olarak ve maksimum agri 10 olarak derecelendirildi), Diz Yaralanmasi ve Osteoartirit Skalasi (DYOS) (puanlama 0 ile 100 arasinda degismektedir. 0 anormal derecede yuksek diz problemleri gosterirken, 100 problemsiz saglikli bir diz gostermektedir) ve Diz Cemiyeti Skorlamasi (DCS) (Maksimum 100 puan olan skala agriya 50, stabiliteye 25 ve eklem hareket acikligina 25 puan atanir) skalalari ile ilk enjeksiyon oncesi ve son enjeksiyondan 1 yil sonra degerlendirildi. Bulgular: Hastalarin tedavi oncesi ve 1. yil takip VAS degerleri sirasi ile 7.36±0.93 (aralik: 5-9) ve 3.27±1.23 (aralik: 1-6) idi. OZS tedavisi VAS skorunda istatistiksel olarak anlamli dusme gostermistir (p<0.01). Hastalarin tedavi oncesi ve 1. yil takip DYOS toplam degerleri sirasi ile 42.39±13.38 (aralik: 21-65) ve 72.36±8.81 (aralik: 54-92) idi. Hastalarin DYOS total skorunda istatistiksel olarak anlamli yukselme saptanmistir (p<0.01). Hastalarin tedavi oncesi ve 1. yil takip DCS degerleri sirasi ile 42.79±10.26 (aralik: 14-61) ve 70.61±9.32 (aralik: 49-84) idi. Hastalarin DCS degerlerinde istatistiksel olarak anlamli yukselme saptanmistir (p<0.01). Sonuc: Agrili diz osteoartriti olan hastalarda inra-artikuler OZS kullanimi agri siddeti, DYS, DYOS ve DCS skorlari acisindan anlamli iyilesmelere yol acmaktadir. Bu bulgular isiginda, OZS tedavisi osteoartritte etkili ve guvenli bir alternatif bir tedavi yontemi olarak degerlendirilebilir.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90807859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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