A. Durhan, A. Şenlikçi, Ender Ergüder, M. Süleyman, K. Koşmaz, U. Mercan, M. R. Pekcici, S. Erel
Aim: De Ritis ratio (aspartate transaminase/alanine transaminase) may be a useful prognostic biomarker for certain malignant tumors. However, the predictive value of the De Ritis ratio before treatment in preoperative staging in patients with breast cancer is unknown. This study aimed to evaluate the De Ritis ratio in benign and malignant breast diseases and investigate the predictive value of it for breast cancer. Methods: Retrospective analysis was made of the clinicopathological data of 301 patients with benign breast disease and breast cancer treated between April 2017 and April 2020 in a single center. 64 Patients were excluded from the study due to chronic illness or incomplete data. The relationship between the De Ritis ratio and clinicopathological findings before treatment was evaluated in patients. The Mann Whitney U test and Kruskal Wallis test were used in the comparisons between groups. Results: Of the total 237 patients, the number of patients with benign breast disease was 96 and the number of the patients with breast cancer was 141. No statistically significant results were determined between the benign breast disease and breast cancer groups, in respect of pre-treatment evaluation of the De Ritis ratio and as a predictive factor for preoperative staging in molecular subtyping, tumor diameter, lymph node metastasis, and Ki 67 index. Conclusion: It was concluded that the De Ritis ratio examined before treatment was not an independent predictive factor in breast cancer diagnosis and staging.
{"title":"Is Aspartate Aminotransferase to Alanine Aminotransferase (De Ritis Ratio) Helpful in Predicting Breast Cancer?","authors":"A. Durhan, A. Şenlikçi, Ender Ergüder, M. Süleyman, K. Koşmaz, U. Mercan, M. R. Pekcici, S. Erel","doi":"10.25000/ACEM.854289","DOIUrl":"https://doi.org/10.25000/ACEM.854289","url":null,"abstract":"Aim: De Ritis ratio (aspartate transaminase/alanine transaminase) may be a useful prognostic biomarker for certain malignant tumors. However, the predictive value of the De Ritis ratio before treatment in preoperative staging in patients with breast cancer is unknown. This study aimed to evaluate the De Ritis ratio in benign and malignant breast diseases and investigate the predictive value of it for breast cancer. Methods: Retrospective analysis was made of the clinicopathological data of 301 patients with benign breast disease and breast cancer treated between April 2017 and April 2020 in a single center. 64 Patients were excluded from the study due to chronic illness or incomplete data. The relationship between the De Ritis ratio and clinicopathological findings before treatment was evaluated in patients. The Mann Whitney U test and Kruskal Wallis test were used in the comparisons between groups. Results: Of the total 237 patients, the number of patients with benign breast disease was 96 and the number of the patients with breast cancer was 141. No statistically significant results were determined between the benign breast disease and breast cancer groups, in respect of pre-treatment evaluation of the De Ritis ratio and as a predictive factor for preoperative staging in molecular subtyping, tumor diameter, lymph node metastasis, and Ki 67 index. Conclusion: It was concluded that the De Ritis ratio examined before treatment was not an independent predictive factor in breast cancer diagnosis and staging.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"8 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78332590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Anatomical details of perianal fistulas can be revealed more clearly by T2-weighted (T2-W) periodically rotated overlapping parallel lines with enhanced reconstruction (BLADE) sequence during magnetic resonance imaging (MRI). This study aimed to compare the efficacy of the T2-W BLADE sequence and the T2-W turbo spin echo (TSE) sequence in diagnosing perianal fistula, as well as to compare the findings with the results obtained using the dynamic contrast-enhanced (DCE) T1-weighted (T1-W) sequence during routine pelvic MRI examination. Methods: Ninety patients (male/female: 67/23) who had undergone pelvic MRI examination (1.5Tesla) for the prediagnosis of perianal fistula were included in this prospective study. In addition to our routine pelvic MRI protocol, T2-W BLADE sequence imaging and T2-W TSE sequence imaging in the axial, sagittal, and coronal planes were performed. Using a three-stage scoring system, two radiologists independently compared the T2-W BLADE and T2-W TSE sequences with each other and then with the DCE T1-W sequence in terms of perianal fistula imaging. Statistical analysis was performed using a sample t-test and the Cronbach’s α test. Results: Compared with the T2-W TSE sequence, the T2-W BLADE sequence was associated with fewer ghosting artifacts, with higher overall image quality, and with clearer visualization of the anatomical details of perianal fistula (p < 0.05). Images with high anatomic details and contrast resolution were obtained using the T2-W BLADE sequence similar to those obtained using the DCE T1-W sequence (p < 0.05). Conclusion: On the basis of the reduced imaging time and on the higher image resolution, T2-W images can be obtained with the BLADE technique for the diagnosis of perianal fistula.
{"title":"Evaluation of perianal fistulas with magnetic resonance imaging: Significance of T2-weighted BLADE sequence in disease diagnosis","authors":"S. Bulut, Z. Sakci","doi":"10.25000/ACEM.882429","DOIUrl":"https://doi.org/10.25000/ACEM.882429","url":null,"abstract":"Aim: Anatomical details of perianal fistulas can be revealed more clearly by T2-weighted (T2-W) periodically rotated overlapping parallel lines with enhanced reconstruction (BLADE) sequence during magnetic resonance imaging (MRI). This study aimed to compare the efficacy of the T2-W BLADE sequence and the T2-W turbo spin echo (TSE) sequence in diagnosing perianal fistula, as well as to compare the findings with the results obtained using the dynamic contrast-enhanced (DCE) T1-weighted (T1-W) sequence during routine pelvic MRI examination. Methods: Ninety patients (male/female: 67/23) who had undergone pelvic MRI examination (1.5Tesla) for the prediagnosis of perianal fistula were included in this prospective study. In addition to our routine pelvic MRI protocol, T2-W BLADE sequence imaging and T2-W TSE sequence imaging in the axial, sagittal, and coronal planes were performed. Using a three-stage scoring system, two radiologists independently compared the T2-W BLADE and T2-W TSE sequences with each other and then with the DCE T1-W sequence in terms of perianal fistula imaging. Statistical analysis was performed using a sample t-test and the Cronbach’s α test. Results: Compared with the T2-W TSE sequence, the T2-W BLADE sequence was associated with fewer ghosting artifacts, with higher overall image quality, and with clearer visualization of the anatomical details of perianal fistula (p < 0.05). Images with high anatomic details and contrast resolution were obtained using the T2-W BLADE sequence similar to those obtained using the DCE T1-W sequence (p < 0.05). Conclusion: On the basis of the reduced imaging time and on the higher image resolution, T2-W images can be obtained with the BLADE technique for the diagnosis of perianal fistula.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91024852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Citgez, E. Baran, Banu Yigit, Soysal Bas, A. Tufan, H. Özşahin
Fibroadenomlar, epitel ve stromal bilesenlerden olusan iyi huylu meme tumorleridir. Cogu yaklasik 1 ila 2 cm boyutlarindadir. Fibroadenom 5 cm'den buyukse, 500 g'dan fazla agirliga sahipse veya meme hacminin en az % 80'ini kapladiginda "dev" olarak tanimlanir. Genellikle 20 yas alti hastalarda gorulur. Kitlenin progresif olarak buyumesi ve boyutlari, malignite suphesine neden olur. Genellikle meme asimetrisine neden olan tek tarafli makromasti olarak kendini gosterir. Bu durumda basit eksizyon ile mukemmel kozmetik sonuclar elde edilemeyebilir. Dev juvenil fibroadenom tanisi alan 12 yasinda bir hastayi sunmaktayiz. Bu durumda, kontralateral meme ile optimal simetri elde etmek icin Batwing mastopeksi teknigi ile cerrahi eksizyon yaptik.
{"title":"Breast conservation with batwing mastopexy for the management of giant juvenile fibroadenoma: A case report of a 12-year-old girl","authors":"B. Citgez, E. Baran, Banu Yigit, Soysal Bas, A. Tufan, H. Özşahin","doi":"10.25000/acem.799406","DOIUrl":"https://doi.org/10.25000/acem.799406","url":null,"abstract":"Fibroadenomlar, epitel ve stromal bilesenlerden olusan iyi huylu meme tumorleridir. Cogu yaklasik 1 ila 2 cm boyutlarindadir. Fibroadenom 5 cm'den buyukse, 500 g'dan fazla agirliga sahipse veya meme hacminin en az % 80'ini kapladiginda \"dev\" olarak tanimlanir. Genellikle 20 yas alti hastalarda gorulur. Kitlenin progresif olarak buyumesi ve boyutlari, malignite suphesine neden olur. Genellikle meme asimetrisine neden olan tek tarafli makromasti olarak kendini gosterir. Bu durumda basit eksizyon ile mukemmel kozmetik sonuclar elde edilemeyebilir. Dev juvenil fibroadenom tanisi alan 12 yasinda bir hastayi sunmaktayiz. Bu durumda, kontralateral meme ile optimal simetri elde etmek icin Batwing mastopeksi teknigi ile cerrahi eksizyon yaptik.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86021186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Baran, Y. C. Appak, B. Aksoy, I. Sert, O. Işık, G. Akpınar, M. O. Öztan, Muhammet Akyüz, A. Anıl, E. Kebapcı, T. Ayna, Y. Guvenli, C. Tuğmen
Mikrovillus inkluzyon hastaligi, konjenital intestinal inatci diyare nedenidir. Yasam boyunca total parenteral beslenme gerekir ve hastalarin sagkalim icin bagirsak nakline ihtiyaci vardir. Yeni Coronavirus Hastaligi 2019 (COVID-19), Ocak 2020'de dunya capinda bir pandemiye neden oldu. Acil cerrahi mudahalelerin pandemi doneminde uygun onlemler alinarak yapilmasi onerilmektedir. Bu olgu sunumunda, uygun kadavra organ bagisi nedeniyle acil ince bagirsak nakli yapilan mikrovillus inkluzyon hastaligi olan bir cocugu sunarak COVID-19 salgini sirasinda ince bagirsak nakli yonetimini tartismayi amacladik.
{"title":"Small bowel transplantation management during COVID-19 pandemic in a child with microvillus inclusion disease from Turkey","authors":"M. Baran, Y. C. Appak, B. Aksoy, I. Sert, O. Işık, G. Akpınar, M. O. Öztan, Muhammet Akyüz, A. Anıl, E. Kebapcı, T. Ayna, Y. Guvenli, C. Tuğmen","doi":"10.25000/acem.785333","DOIUrl":"https://doi.org/10.25000/acem.785333","url":null,"abstract":"Mikrovillus inkluzyon hastaligi, konjenital intestinal inatci diyare nedenidir. Yasam boyunca total parenteral beslenme gerekir ve hastalarin sagkalim icin bagirsak nakline ihtiyaci vardir. Yeni Coronavirus Hastaligi 2019 (COVID-19), Ocak 2020'de dunya capinda bir pandemiye neden oldu. Acil cerrahi mudahalelerin pandemi doneminde uygun onlemler alinarak yapilmasi onerilmektedir. Bu olgu sunumunda, uygun kadavra organ bagisi nedeniyle acil ince bagirsak nakli yapilan mikrovillus inkluzyon hastaligi olan bir cocugu sunarak COVID-19 salgini sirasinda ince bagirsak nakli yonetimini tartismayi amacladik.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77842391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amac: Antibiyotiklerin uzun yillar boyunca kontrolsuz bir sekilde kullanilmasi bakteriyel DNA mutasyonuna yol acmistir ve bunun sonucunda bakteriler antibiyotiklere direncli hale gelmistir. Metisiline direncli Stafilokok aureus (MRSA) bakterileri, bu tur direncli bakteriler arasinda olup vucudun bagisiklik sisteminin dusmesi sonucu kolayca enfeksiyona sebep olabilmekte ve yara iyilesmesini onemli olcude geciktirmektedirler. Bu sorunun ustesinden gelmek icin farkli tedavi yontemleri arastirilmaktadir. Antimikrobiyal fotodinamik tedavi enfeksiyonlarin yok edilmesine yonelik alternatif bir tedavi olmaya adaydir. Bu calismanin amaci ise klorin e6’nin MRSA’nin fotoinaktivasyonu uzerindeki etkisini ve bu mekanizmada etanolun sinerjik rolunu arastirmaktir. Yontemler: Bu calismada MRSA'nin fotoinaktivasyonu icin 655 nm lazer isigi ve fotosensitizan olarak Klorin e6 incelenmistir. Ayrica, % 20 etanol kullanimiyla mekanizmanin antimikrobiyal etkinligi dusuk isik enerjisi yogunluklari ve fotosensitizan konsantrasyonlari ile arttirilmaya calisilmistir. Her uygulamadan sonra canli bakteri hucre sayisini belirlemek icin koloni sayma yontemi kullanilmistir. Bulgular: Uygulamalar arasinda 20 μM Klorin e6 ile 25 J/cm2 enerji yogunlugu ve 10 μM Klorin e6 ile 50 J/cm2 enerji yogunlugu en yuksek bakterisidal aktiviteyi saglamistir. %20 etanolun mekanizmaya eklenmesiyle en etkili fotosensitizan konsantrasyonu 2 μM’a dusurulerek 25 J/cm2 enerji yogunlugu ile birlikte daha etkili bir sonuc elde edilebilmistir. Sonuc: Klorin e6 aracili fotodinamik tedavi, MRSA'yi yok etmekte basarili olmustur ve etanol ilavesi, daha dusuk isik yogunlugu ve fotosensitizan konsantrasyonu ile fotodinamik tedavide daha yuksek antibakteriyel aktivite elde etme firsati saglamistir.
{"title":"Photodynamic action of chlorin e6 against methicillin resistant staphylococcus aureus with the aid of ethanol","authors":"Nermin Topaloğlu Avşar, Emel Bakay, Aziz Kolkiran","doi":"10.25000/acem.740365","DOIUrl":"https://doi.org/10.25000/acem.740365","url":null,"abstract":"Amac: Antibiyotiklerin uzun yillar boyunca kontrolsuz bir sekilde kullanilmasi bakteriyel DNA mutasyonuna yol acmistir ve bunun sonucunda bakteriler antibiyotiklere direncli hale gelmistir. Metisiline direncli Stafilokok aureus (MRSA) bakterileri, bu tur direncli bakteriler arasinda olup vucudun bagisiklik sisteminin dusmesi sonucu kolayca enfeksiyona sebep olabilmekte ve yara iyilesmesini onemli olcude geciktirmektedirler. Bu sorunun ustesinden gelmek icin farkli tedavi yontemleri arastirilmaktadir. Antimikrobiyal fotodinamik tedavi enfeksiyonlarin yok edilmesine yonelik alternatif bir tedavi olmaya adaydir. Bu calismanin amaci ise klorin e6’nin MRSA’nin fotoinaktivasyonu uzerindeki etkisini ve bu mekanizmada etanolun sinerjik rolunu arastirmaktir. Yontemler: Bu calismada MRSA'nin fotoinaktivasyonu icin 655 nm lazer isigi ve fotosensitizan olarak Klorin e6 incelenmistir. Ayrica, % 20 etanol kullanimiyla mekanizmanin antimikrobiyal etkinligi dusuk isik enerjisi yogunluklari ve fotosensitizan konsantrasyonlari ile arttirilmaya calisilmistir. Her uygulamadan sonra canli bakteri hucre sayisini belirlemek icin koloni sayma yontemi kullanilmistir. Bulgular: Uygulamalar arasinda 20 μM Klorin e6 ile 25 J/cm2 enerji yogunlugu ve 10 μM Klorin e6 ile 50 J/cm2 enerji yogunlugu en yuksek bakterisidal aktiviteyi saglamistir. %20 etanolun mekanizmaya eklenmesiyle en etkili fotosensitizan konsantrasyonu 2 μM’a dusurulerek 25 J/cm2 enerji yogunlugu ile birlikte daha etkili bir sonuc elde edilebilmistir. Sonuc: Klorin e6 aracili fotodinamik tedavi, MRSA'yi yok etmekte basarili olmustur ve etanol ilavesi, daha dusuk isik yogunlugu ve fotosensitizan konsantrasyonu ile fotodinamik tedavide daha yuksek antibakteriyel aktivite elde etme firsati saglamistir.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89355532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kokurcan, H. Karadağ, Selma Ercan Doğu, Funda Erdi, S. Örsel
Amac: Bu calismanin amaci sizofreni hastalarinda tedaviye uyumu ve icgoru ile iliskili klinik degiskenleri degerlendirmektir. Yontemler: Kesitsel nitelikteki bu calismaya Saglik Bilimleri Universitesi Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi Psikiyatri Poliklinigi’ne basvuran 229 sizofreni hastasi dahil edildi. Tum katilimcilara sosyodemografik veri formu, Morisky Tedaviye Uyum Olcegi, Icgorunun Uc Bilesenini Degerlendirme Olcegi, Kisa Psikiyatrik Degerlendirme Olcegi, Pozitif ve Negatif Belirtileri Degerlendirme Olcegi, Calgary Şizofrenide Depresyon Olcegi ve Islevselligin Genel Degerlendirilmesi Olcegi uygulanmistir. Istatiksel analizde tanimlayici analizler, Pearson Korelasyon Analizi ve lojistik regresyon analizi kullanildi. Bulgular: Şizofrenide dusuk tedavi uyumu bulunmasi erkek cinsiyet, dusuk icgoru duzeyi, yuksek psikotik belirti siddeti ve dusuk islevsellik duzeyi ile iliskili bulundu. Icgoru duzeyi ise psikotik belirti siddeti, hastaligin suresi ve ortalama antipsikotik ilac dozu ile negatif korelasyon gosterirken; gec baslangic yasi ve yuksek islevsellik duzeyi ile pozitif korelasyon gosterdi. Lojistik regresyon analizinde ise islevsellik duzeyinin dusuk tedavi uyumunu ongormede daha etkili oldugu belirlendi. Sonuc: Dusuk tedavi uyumu ve icgoru duzeyi yuksek klinik belirti siddetiyle ve dusuk islevsellik duzeyiyle guclu korelasyon gosterdi. Tedavi uyumu ve icgoru duzeyi hastalarin iyilik durumu uzerinde onemli prediktif faktorler olarak saptandi. Bu nedenle psikotik belirtiler direncli olsa dahi sizofreni hastalarinda tedavi uyumu ve icgoruyu arttirmaya yonelik psikososyal tedaviler uygulanmalidir. Şizofreni hastalarinda tedavi uyumu ve icgoru duzeyi ile iliskili klinik degiskenlerin daha iyi anlasilmasi icin gelecekte yapilacak calismalar onemli olacaktir.
{"title":"Clinical Correlates of Treatment Adherence and Insight in Patients with Schizophrenia","authors":"A. Kokurcan, H. Karadağ, Selma Ercan Doğu, Funda Erdi, S. Örsel","doi":"10.25000/acem.717027","DOIUrl":"https://doi.org/10.25000/acem.717027","url":null,"abstract":"Amac: Bu calismanin amaci sizofreni hastalarinda tedaviye uyumu ve icgoru ile iliskili klinik degiskenleri degerlendirmektir. Yontemler: Kesitsel nitelikteki bu calismaya Saglik Bilimleri Universitesi Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi Psikiyatri Poliklinigi’ne basvuran 229 sizofreni hastasi dahil edildi. Tum katilimcilara sosyodemografik veri formu, Morisky Tedaviye Uyum Olcegi, Icgorunun Uc Bilesenini Degerlendirme Olcegi, Kisa Psikiyatrik Degerlendirme Olcegi, Pozitif ve Negatif Belirtileri Degerlendirme Olcegi, Calgary Şizofrenide Depresyon Olcegi ve Islevselligin Genel Degerlendirilmesi Olcegi uygulanmistir. Istatiksel analizde tanimlayici analizler, Pearson Korelasyon Analizi ve lojistik regresyon analizi kullanildi. Bulgular: Şizofrenide dusuk tedavi uyumu bulunmasi erkek cinsiyet, dusuk icgoru duzeyi, yuksek psikotik belirti siddeti ve dusuk islevsellik duzeyi ile iliskili bulundu. Icgoru duzeyi ise psikotik belirti siddeti, hastaligin suresi ve ortalama antipsikotik ilac dozu ile negatif korelasyon gosterirken; gec baslangic yasi ve yuksek islevsellik duzeyi ile pozitif korelasyon gosterdi. Lojistik regresyon analizinde ise islevsellik duzeyinin dusuk tedavi uyumunu ongormede daha etkili oldugu belirlendi. Sonuc: Dusuk tedavi uyumu ve icgoru duzeyi yuksek klinik belirti siddetiyle ve dusuk islevsellik duzeyiyle guclu korelasyon gosterdi. Tedavi uyumu ve icgoru duzeyi hastalarin iyilik durumu uzerinde onemli prediktif faktorler olarak saptandi. Bu nedenle psikotik belirtiler direncli olsa dahi sizofreni hastalarinda tedavi uyumu ve icgoruyu arttirmaya yonelik psikososyal tedaviler uygulanmalidir. Şizofreni hastalarinda tedavi uyumu ve icgoru duzeyi ile iliskili klinik degiskenlerin daha iyi anlasilmasi icin gelecekte yapilacak calismalar onemli olacaktir.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77681934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: We set out in this study to investigate whether the neutrophil-to-lymphocyte ratio (NLR) is a predictor in deciding whether to either continue palliative chemotherapy or choose the best supportive care (BSC) for advanced cancer patients. Methods: Those with advanced solid tumors who had died after palliative chemotherapy were included the study. The patients were divided into two groups based on the time between the beginning of their last chemotherapy regimen and death (DCD), at ≤ 60 or > 60 days. Neutrophil-to-lymphocyte ratio was calculated using the laboratory values taken before the beginning of the last chemotherapy line. The determinant factors of ≤ 60-days DCD were examined by logistic regression analysis, and a statistical significance level of alpha was accepted as p < 0.05. Results: The study included 404 patients, with the mean age at diagnosis of 61.7±12.0 years. The mean NLR was calculated as 11.3±27.1. In the univariate analysis for determining ≤ 60-days DCD, breast and colorectal cancers, ECOG status, single agent chemotherapy usage, neutrophil count, lymphocyte count and NLR were all found to be significant factors. The cutoff value determining the ≤ 60-days DCD, was determined as NLR ≥ 3.59. In logistic regression analysis, NLR ≥ 3.59, as well as ECOG status, were found to be significant factors. Conclusion: The neutrophil-lymphocyte ratio, combined with ECOG, can predict survival in patients with solid advanced tumors and can therefore help clinicians in choosing to either administer chemotherapy to their patients or direct them to the best supportive care.
目的:我们在本研究中探讨中性粒细胞与淋巴细胞比率(NLR)是否是决定晚期癌症患者是否继续姑息性化疗或选择最佳支持治疗(BSC)的预测因子。方法:晚期实体瘤患者在姑息性化疗后死亡。根据患者从最后一次化疗方案开始到死亡(DCD)的时间分为≤60天和> 60天两组。中性粒细胞与淋巴细胞的比率使用最后一次化疗开始前的实验室值计算。≤60 d DCD的决定因素采用logistic回归分析，p < 0.05为alpha水平。结果:纳入404例患者，平均诊断年龄61.7±12.0岁。NLR平均值为11.3±27.1。在确定≤60天DCD的单因素分析中，乳腺癌和结直肠癌、ECOG状态、单药化疗使用、中性粒细胞计数、淋巴细胞计数和NLR均为显著因素。确定≤60天DCD的截止值为NLR≥3.59。logistic回归分析发现，NLR≥3.59、ECOG状态为显著影响因素。结论:中性粒细胞-淋巴细胞比值结合ECOG可预测晚期实体肿瘤患者的生存，因此可以帮助临床医生选择对患者进行化疗或指导他们进行最佳支持治疗。
{"title":"Neutrophil-to-Lymphocyte Ratio May Guide the Choice of Treatment in Metastatic Cancer Patients: Chemotherapy or Best Supportive Care","authors":"S. Arıcı, R. Çekin","doi":"10.25000/acem.803359","DOIUrl":"https://doi.org/10.25000/acem.803359","url":null,"abstract":"Aim: We set out in this study to investigate whether the neutrophil-to-lymphocyte ratio (NLR) is a predictor in deciding whether to either continue palliative chemotherapy or choose the best supportive care (BSC) for advanced cancer patients. Methods: Those with advanced solid tumors who had died after palliative chemotherapy were included the study. The patients were divided into two groups based on the time between the beginning of their last chemotherapy regimen and death (DCD), at ≤ 60 or > 60 days. Neutrophil-to-lymphocyte ratio was calculated using the laboratory values taken before the beginning of the last chemotherapy line. The determinant factors of ≤ 60-days DCD were examined by logistic regression analysis, and a statistical significance level of alpha was accepted as p < 0.05. Results: The study included 404 patients, with the mean age at diagnosis of 61.7±12.0 years. The mean NLR was calculated as 11.3±27.1. In the univariate analysis for determining ≤ 60-days DCD, breast and colorectal cancers, ECOG status, single agent chemotherapy usage, neutrophil count, lymphocyte count and NLR were all found to be significant factors. The cutoff value determining the ≤ 60-days DCD, was determined as NLR ≥ 3.59. In logistic regression analysis, NLR ≥ 3.59, as well as ECOG status, were found to be significant factors. Conclusion: The neutrophil-lymphocyte ratio, combined with ECOG, can predict survival in patients with solid advanced tumors and can therefore help clinicians in choosing to either administer chemotherapy to their patients or direct them to the best supportive care.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73357221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Venugopal, A. Muralidhar, Hemalata Mahantappa, Sadaf Ahmad
Xeroderma Pigmentosum is an inherited disorder of DNA repair characterised by defective nucleotide excision repair, which is involved in repairing ultraviolet rays induced cross linking of pyramidine residues. Affected individuals are at increased risk of development of mucocutaneous cancers at a much earlier age than normal. This genodermatosis affects both sexes and all races. The incidence in India is still unknown. We report one such case of a nine year old boy with co-existent squamous cell carcinoma and basal cell carcinoma of the face.
{"title":"Rare occurrence of coexistent squamous cell carcinoma and basal cell carcinoma in a case of Xeroderma Pigmentosum","authors":"S. Venugopal, A. Muralidhar, Hemalata Mahantappa, Sadaf Ahmad","doi":"10.25000/acem.720032","DOIUrl":"https://doi.org/10.25000/acem.720032","url":null,"abstract":"Xeroderma Pigmentosum is an inherited disorder of DNA repair characterised by defective nucleotide excision repair, which is involved in repairing ultraviolet rays induced cross linking of pyramidine residues. Affected individuals are at increased risk of development of mucocutaneous cancers at a much earlier age than normal. This genodermatosis affects both sexes and all races. The incidence in India is still unknown. We report one such case of a nine year old boy with co-existent squamous cell carcinoma and basal cell carcinoma of the face.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83716660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amac: Calismamizda karaciger metastazlarinda ultrason esliginde yapilan mikrodalga ablasyon tedavisi sonrasi gelisen lokal nuksun karaciger kapsulu ve ablasyon trakti ile ilgili ozelliklerinin degerlendirlmesi amaclanmistir. Yontemler: Şubat 2016 ile Aralik 2019 tarihleri arasinda mevcut karaciger metastazina US rehberliginde perkutan mikrodalga abalasyon tedavisi yapilan 101 olgu retrospektif olarak degerlendirildi. Toplam 32 lokal nukse sahip ablate lezyonu bulunan 19 hasta calismaya dahil edildi. Metastazlarin histopatolojik tipleri, ablasyon oncesi ozellikleri ve ablasyon islemine ait bilgiler not edildi. Tumorun boyutlari ve tumor ile karaciger kapsulu arasindaki en kisa mesafe olculdu. Lokal nuksun karaciger kapsulune ve ablasyon tarktina gore tarafi ve yerlesimi ile sekil ozellikleri degerlendirildi. Bulgular: Ortanca lokal nukssuresi 8.46±4.54 ay (3-20 araliginda) olarak bulundu. Hasta ve lezyon bagimli lokal nuks oranlari sirasiyla 19% ve 20% idi. Parankim ici yerlesimli lezyonlara ait lokal nukslerin tumu ablasyon traktinin ucu ya da yaninda yerlesimli olarak bulundu ve bu iliski istatistiksel olarak anlamliydi (p=0.035). Damar yakinligi ile lokal nuksun sekli ve lokal nuksun tarafi ile sekli arasinda istatistiksel olarak anlamli iliski saptanmadi (sirasiyla p=0.704 ve 0.683). Sonuc: Calismamizda parankimal yerlesimli lezyonlardan gelisen lokal rekurrensin hepsinin ablasyon traktinin uc ve yan kesimlerinden gelistigi ortaya konulmustur. Ayrica lokal rekurrensin karaciger kapsulu ve ablasyon trakti ile iliskili bir takim ozellikleri ve bu bulgularin birbiri ile ilgili iliskileri ortaya konuldu.
{"title":"Capsule and Ablation Tract Related Features of Local Recurrence in Ultrasound Guided Microwave Ablation of Liver Metastases","authors":"S. Arıbal, Eyup Kaya","doi":"10.25000/acem.766188","DOIUrl":"https://doi.org/10.25000/acem.766188","url":null,"abstract":"Amac: Calismamizda karaciger metastazlarinda ultrason esliginde yapilan mikrodalga ablasyon tedavisi sonrasi gelisen lokal nuksun karaciger kapsulu ve ablasyon trakti ile ilgili ozelliklerinin degerlendirlmesi amaclanmistir. Yontemler: Şubat 2016 ile Aralik 2019 tarihleri arasinda mevcut karaciger metastazina US rehberliginde perkutan mikrodalga abalasyon tedavisi yapilan 101 olgu retrospektif olarak degerlendirildi. Toplam 32 lokal nukse sahip ablate lezyonu bulunan 19 hasta calismaya dahil edildi. Metastazlarin histopatolojik tipleri, ablasyon oncesi ozellikleri ve ablasyon islemine ait bilgiler not edildi. Tumorun boyutlari ve tumor ile karaciger kapsulu arasindaki en kisa mesafe olculdu. Lokal nuksun karaciger kapsulune ve ablasyon tarktina gore tarafi ve yerlesimi ile sekil ozellikleri degerlendirildi. Bulgular: Ortanca lokal nukssuresi 8.46±4.54 ay (3-20 araliginda) olarak bulundu. Hasta ve lezyon bagimli lokal nuks oranlari sirasiyla 19% ve 20% idi. Parankim ici yerlesimli lezyonlara ait lokal nukslerin tumu ablasyon traktinin ucu ya da yaninda yerlesimli olarak bulundu ve bu iliski istatistiksel olarak anlamliydi (p=0.035). Damar yakinligi ile lokal nuksun sekli ve lokal nuksun tarafi ile sekli arasinda istatistiksel olarak anlamli iliski saptanmadi (sirasiyla p=0.704 ve 0.683). Sonuc: Calismamizda parankimal yerlesimli lezyonlardan gelisen lokal rekurrensin hepsinin ablasyon traktinin uc ve yan kesimlerinden gelistigi ortaya konulmustur. Ayrica lokal rekurrensin karaciger kapsulu ve ablasyon trakti ile iliskili bir takim ozellikleri ve bu bulgularin birbiri ile ilgili iliskileri ortaya konuldu.","PeriodicalId":8220,"journal":{"name":"ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84337106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：