首页 > 最新文献

Annals of Nutrition and Metabolism最新文献

英文 中文
Erratum. 勘误表。
IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-08-22 DOI: 10.1159/000533238
{"title":"Erratum.","authors":"","doi":"10.1159/000533238","DOIUrl":"10.1159/000533238","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"400"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum. 勘误表。
IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-08-22 DOI: 10.1159/000533240
{"title":"Erratum.","authors":"","doi":"10.1159/000533240","DOIUrl":"10.1159/000533240","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"402"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IUNS 22nd International Congress of Nutrition. IUNS 第 22 届国际营养大会。
IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-07-14 DOI: 10.1159/000530787
Hisanori Kato, Nobuko Murayama, Jaques Delarue, J Alfredo Martínez
{"title":"IUNS 22nd International Congress of Nutrition.","authors":"Hisanori Kato, Nobuko Murayama, Jaques Delarue, J Alfredo Martínez","doi":"10.1159/000530787","DOIUrl":"https://doi.org/10.1159/000530787","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 Suppl 1 ","pages":"9-11"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum. 勘误表。
IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-08-22 DOI: 10.1159/000533244
{"title":"Erratum.","authors":"","doi":"10.1159/000533244","DOIUrl":"10.1159/000533244","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"406"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coexistent GLIM-Defined Malnutrition and Sarcopenia Increase the Long-Term Mortality Risk in Hospitalized Patients with Decompensated Cirrhosis. GLIM定义的营养不良和少肌症共存会增加失代偿期肝硬化住院患者的长期死亡率。
IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-09-19 DOI: 10.1159/000534152
Han Wang, Sipu Wang, Chaoqun Li, Wanting Yang, Gaoyue Guo, Yangyang Hui, Xiaoyu Wang, Binxin Cui, Xiaofei Fan, Huanli Jiao, Chao Sun

Introduction: The synergistic impact of coexistent malnutrition and sarcopenia on morality in hospitalized patients with decompensated cirrhosis remains elusive. This prospective cohort study aimed to delineate the prevalence concerning coexistence of malnutrition and sarcopenia and the prognosticating role on long-term mortality among cirrhosis.

Methods: Adult cirrhotic patients with decompensated episodes between 2019 and 2021 were consecutively enrolled. Malnutrition and sarcopenia were diagnosed according to the Global Leadership Initiative on Malnutrition (GLIM) criteria and the European Working Group on Sarcopenia in Older People (EWGSOP2) algorithm, respectively. The entire cohort was divided into three groups: non-malnutrition and non-sarcopenia (NN), malnutrition or sarcopenia, and coexistent malnutrition and sarcopenia (MS). Log-rank test and multivariate Cox regression model were utilized to evaluate survival status and independent risk factors for mortality, respectively.

Results: Our findings indicated that malnutrition manifested in 44.6% of inpatients with decompensated cirrhosis, while sarcopenia presented in 16.4% of the entire cohort, indicative of a prevalence of 14.7% regarding coexistent malnutrition and sarcopenia. The Kaplan-Meier graphic demonstrated a significant difference regarding survival curves among the three groups, referring to the MS group presented with the lowest survival rate (log-rank test: p < 0.001). Moreover, coexistent malnutrition and sarcopenia were associated with nearly 4 times higher mortality risk (model 1: hazard ratio [HR] = 3.31, 95% confidence interval [CI]: 1.20-9.13, p = 0.020; model 2: HR = 4.34, 95% CI: 1.52-12.4, p = 0.006) in comparison with patients without any condition (NN group).

Conclusions: Malnutrition and sarcopenia had superimposed negative impacts on inpatients with decompensated cirrhosis. It is imperative to identify this vulnerable subset to provide prompt therapeutic intervention for better prognosis.

引言:营养不良和少肌症并存对失代偿期肝硬化住院患者道德的协同影响仍然难以捉摸。这项前瞻性队列研究旨在描述肝硬化患者营养不良和少肌症共存的患病率以及对长期死亡率的预测作用。方法:连续纳入2019年至2021年间出现失代偿期的成年肝硬化患者。营养不良和少肌症分别根据全球营养不良领导倡议(GLIM)标准和欧洲老年人少肌症工作组(EWGSOP2)算法进行诊断。整个队列被分为三组:非营养不良和非少肌症(NN)、营养不良或少肌症以及共存的营养不良和少肌症。对数秩检验和多变量Cox回归模型分别用于评估生存状态和死亡率的独立危险因素。结果:我们的研究结果表明,44.6%的失代偿性肝硬化住院患者出现营养不良,而在整个队列中,16.4%的患者出现少肌症,这表明营养不良和少肌症共存的患病率为14.7%。Kaplan-Meier图显示了三组之间关于生存曲线的显著差异,参考生存率最低的MS组(log-rank检验:P结论:营养不良和少肌症对失代偿期肝硬化住院患者有叠加的负面影响。必须识别这些易受感染的亚群,为更好的预后提供及时的治疗干预。
{"title":"Coexistent GLIM-Defined Malnutrition and Sarcopenia Increase the Long-Term Mortality Risk in Hospitalized Patients with Decompensated Cirrhosis.","authors":"Han Wang, Sipu Wang, Chaoqun Li, Wanting Yang, Gaoyue Guo, Yangyang Hui, Xiaoyu Wang, Binxin Cui, Xiaofei Fan, Huanli Jiao, Chao Sun","doi":"10.1159/000534152","DOIUrl":"10.1159/000534152","url":null,"abstract":"<p><strong>Introduction: </strong>The synergistic impact of coexistent malnutrition and sarcopenia on morality in hospitalized patients with decompensated cirrhosis remains elusive. This prospective cohort study aimed to delineate the prevalence concerning coexistence of malnutrition and sarcopenia and the prognosticating role on long-term mortality among cirrhosis.</p><p><strong>Methods: </strong>Adult cirrhotic patients with decompensated episodes between 2019 and 2021 were consecutively enrolled. Malnutrition and sarcopenia were diagnosed according to the Global Leadership Initiative on Malnutrition (GLIM) criteria and the European Working Group on Sarcopenia in Older People (EWGSOP2) algorithm, respectively. The entire cohort was divided into three groups: non-malnutrition and non-sarcopenia (NN), malnutrition or sarcopenia, and coexistent malnutrition and sarcopenia (MS). Log-rank test and multivariate Cox regression model were utilized to evaluate survival status and independent risk factors for mortality, respectively.</p><p><strong>Results: </strong>Our findings indicated that malnutrition manifested in 44.6% of inpatients with decompensated cirrhosis, while sarcopenia presented in 16.4% of the entire cohort, indicative of a prevalence of 14.7% regarding coexistent malnutrition and sarcopenia. The Kaplan-Meier graphic demonstrated a significant difference regarding survival curves among the three groups, referring to the MS group presented with the lowest survival rate (log-rank test: p &lt; 0.001). Moreover, coexistent malnutrition and sarcopenia were associated with nearly 4 times higher mortality risk (model 1: hazard ratio [HR] = 3.31, 95% confidence interval [CI]: 1.20-9.13, p = 0.020; model 2: HR = 4.34, 95% CI: 1.52-12.4, p = 0.006) in comparison with patients without any condition (NN group).</p><p><strong>Conclusions: </strong>Malnutrition and sarcopenia had superimposed negative impacts on inpatients with decompensated cirrhosis. It is imperative to identify this vulnerable subset to provide prompt therapeutic intervention for better prognosis.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"423-433"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41092118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IUNS 22nd International Congress of Nutrition. 第22届国际营养大会。
IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 DOI: 10.1159/000530787
Hisanori Kato, Nobuko Murayama, Jaques Delarue, J Alfredo Martínez
{"title":"IUNS 22nd International Congress of Nutrition.","authors":"Hisanori Kato,&nbsp;Nobuko Murayama,&nbsp;Jaques Delarue,&nbsp;J Alfredo Martínez","doi":"10.1159/000530787","DOIUrl":"https://doi.org/10.1159/000530787","url":null,"abstract":"","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 Suppl 1 ","pages":"9-11"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10386665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Reduced Ability to Perform Activities of Daily Living Is Associated with Prolonged Duration before Rehabilitation Initiation and Lower Dietary Intake of Patients with Chronic Obstructive Pulmonary Disease Exacerbation. 进行日常生活活动的能力降低与慢性阻塞性肺病恶化患者开始康复前的持续时间延长和饮食摄入减少有关。
IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-10-30 DOI: 10.1159/000534697
Yohei Oyama, Hiroomi Tatsumi, Rie Tokunou, Natsuko Taniguchi, Yoshiki Masuda

Introduction: Patients with exacerbated chronic obstructive pulmonary disease (COPD) have a reduced ability to perform activities of daily living (ADLs). Rehabilitation programs (RPs) and nutritional therapy may affect the ability to perform ADLs.

Objective: The objective of the study was to clarify the factors associated with reduced ability to perform ADLs in patients with COPD exacerbation.

Subjects/methods: A multivariate analysis of 75 patients (mean age, 77 years) with COPD exacerbation, divided into the Barthel index (BI) decline (△BI decreased ≥15) and without BI decline (△BI decreased ≤10) groups, was performed. Patient characteristics, duration before RP initiation, functional variables, and nutrition-related variables were compared between the groups.

Results: The degree of dyspnea and serum albumin levels before and at RP initiation were significantly lower in the BI decline group. The Hoffer classification score and duration between hospital admission and RP initiation were significantly higher and longer, respectively, in the BI decline group. The duration between hospital admission and RP initiation and dietary intake at RP initiation were independent predictors of reduced ability to perform ADLs.

Conclusions: Early RP initiation and aggressive nutritional therapy may mitigate the risk of reduced ability to perform ADLs, thus decreasing dependence and disability in patients with COPD exacerbation.

引言:慢性阻塞性肺病(COPD)加重患者的日常生活活动能力下降。康复计划(RP)和营养治疗可能会影响COPD急性加重期患者的日常生活能力。目的:阐明与日常生活能力下降相关的因素。受试者/方法:对75名COPD恶化患者(平均年龄77岁)进行多变量分析,分为Barthel指数(BI)下降(△BI下降≥15)且无BI下降(△BI下降≤10)组。比较两组患者的特点、RP开始前的持续时间、功能变量和营养相关变量。结果:BI下降组在RP开始前和开始时的呼吸困难程度和血清白蛋白水平显著降低。BI下降组的Hoffer分类得分和住院与RP开始之间的持续时间分别显著较高和较长。从入院到RP开始的持续时间,以及RP开始时的饮食摄入,是执行ADL能力下降的独立预测因素。结论:早期RP开始和积极的营养治疗可以降低执行ADL的能力下降的风险,从而降低COPD恶化患者的依赖性和残疾。
{"title":"The Reduced Ability to Perform Activities of Daily Living Is Associated with Prolonged Duration before Rehabilitation Initiation and Lower Dietary Intake of Patients with Chronic Obstructive Pulmonary Disease Exacerbation.","authors":"Yohei Oyama, Hiroomi Tatsumi, Rie Tokunou, Natsuko Taniguchi, Yoshiki Masuda","doi":"10.1159/000534697","DOIUrl":"10.1159/000534697","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with exacerbated chronic obstructive pulmonary disease (COPD) have a reduced ability to perform activities of daily living (ADLs). Rehabilitation programs (RPs) and nutritional therapy may affect the ability to perform ADLs.</p><p><strong>Objective: </strong>The objective of the study was to clarify the factors associated with reduced ability to perform ADLs in patients with COPD exacerbation.</p><p><strong>Subjects/methods: </strong>A multivariate analysis of 75 patients (mean age, 77 years) with COPD exacerbation, divided into the Barthel index (BI) decline (△BI decreased ≥15) and without BI decline (△BI decreased ≤10) groups, was performed. Patient characteristics, duration before RP initiation, functional variables, and nutrition-related variables were compared between the groups.</p><p><strong>Results: </strong>The degree of dyspnea and serum albumin levels before and at RP initiation were significantly lower in the BI decline group. The Hoffer classification score and duration between hospital admission and RP initiation were significantly higher and longer, respectively, in the BI decline group. The duration between hospital admission and RP initiation and dietary intake at RP initiation were independent predictors of reduced ability to perform ADLs.</p><p><strong>Conclusions: </strong>Early RP initiation and aggressive nutritional therapy may mitigate the risk of reduced ability to perform ADLs, thus decreasing dependence and disability in patients with COPD exacerbation.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"485-492"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glutamate-Sensing Genes Are Conserved among Populations Compared to Glutamate Metabolism Genes. 与谷氨酸代谢基因相比,谷氨酸感知基因在群体中是保守的。
IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-11-11 DOI: 10.1159/000535181
Kosuke Goto, Yoko Masuzawa, Masanori Kohmura, Asuka Takumi, Haruko Takeyama, Satoru Miyazaki, Takashi Gojobori, Katsuhiko Mineta

Introduction: Glutamate is a representative taste molecule with an umami flavor and is a major nutrient found abundantly in nature. Furthermore, it plays a significant role in the human body as a key metabolic intermediate and neurotransmitter. Therefore, the divergence of glutamate functions among populations during their evolution is of particular interest with a hypothesis that the genetic variation can lead to understanding divergence in taste perception. To elucidate variation in glutamate applications and to deepen our understanding of taste perception, we examined the nucleotide diversity of genes associated with glutamate sensing and metabolism among human populations.

Methods: We first established 67 genes related to glutamate sensing and metabolism based on the database and literature survey. Then, for those genes, we used a population genomics approach based on ten populations over 76,156 human genomes in the gnomAD database.

Results: Statistical tests of means and medians of the minor allele frequencies did not show any significant difference among populations. However, we observed substantial differences between two functional groups, glutamate sensing and glutamate metabolism, in populations of Latino/admixed American, Ashkenazi Jewish, and Others. Interestingly, we could find significant differences between the African population and the East Asian population at the single nucleotide polymorphism level of glutamate metabolism genes, but no clear differences were noted in glutamate-sensing genes. These suggest that glutamate-sensing genes are under the functional constraint compared to glutamate metabolism genes.

Conclusion: Thus, glutamate-sensing genes and metabolism genes have a contrasting mode of the evolution, and glutamate-sensing genes are conservatively evolved, indicating its functional importance.

谷氨酸是具有鲜味的代表性味觉分子,是自然界中丰富存在的主要营养物质。此外,它作为一种关键的代谢中间体和神经递质在人体中起着重要作用。因此,在种群进化过程中,谷氨酸功能的差异是一个特别有趣的假设,即遗传变异可以导致理解味觉感知的差异。为了阐明谷氨酸应用的变化并加深我们对味觉的理解,我们研究了人类群体中与谷氨酸感知和代谢相关的基因的核苷酸多样性。方法:首先在数据库和文献调查的基础上,建立了67个与谷氨酸感知和代谢相关的基因。然后,对于这些基因,我们使用了基于gnomAD数据库中超过76,156个人类基因组的10个群体的群体基因组学方法。结果:小等位基因频率的均值和中位数在人群间无统计学差异。然而,在拉丁裔/混血儿美国人、德系犹太人和其他人群中,我们观察到谷氨酸感知和谷氨酸代谢两个功能组之间存在实质性差异。有趣的是,我们发现非洲人群和东亚人群在谷氨酸代谢基因的单核苷酸多态性水平上存在显著差异,但在谷氨酸感应基因上没有明显差异。这表明与谷氨酸代谢基因相比,谷氨酸感知基因在功能上受到限制。结论:由此可见,谷氨酸感知基因与代谢基因的进化模式截然不同,谷氨酸感知基因的进化较为保守,说明其功能的重要性。
{"title":"Glutamate-Sensing Genes Are Conserved among Populations Compared to Glutamate Metabolism Genes.","authors":"Kosuke Goto, Yoko Masuzawa, Masanori Kohmura, Asuka Takumi, Haruko Takeyama, Satoru Miyazaki, Takashi Gojobori, Katsuhiko Mineta","doi":"10.1159/000535181","DOIUrl":"10.1159/000535181","url":null,"abstract":"<p><strong>Introduction: </strong>Glutamate is a representative taste molecule with an umami flavor and is a major nutrient found abundantly in nature. Furthermore, it plays a significant role in the human body as a key metabolic intermediate and neurotransmitter. Therefore, the divergence of glutamate functions among populations during their evolution is of particular interest with a hypothesis that the genetic variation can lead to understanding divergence in taste perception. To elucidate variation in glutamate applications and to deepen our understanding of taste perception, we examined the nucleotide diversity of genes associated with glutamate sensing and metabolism among human populations.</p><p><strong>Methods: </strong>We first established 67 genes related to glutamate sensing and metabolism based on the database and literature survey. Then, for those genes, we used a population genomics approach based on ten populations over 76,156 human genomes in the gnomAD database.</p><p><strong>Results: </strong>Statistical tests of means and medians of the minor allele frequencies did not show any significant difference among populations. However, we observed substantial differences between two functional groups, glutamate sensing and glutamate metabolism, in populations of Latino/admixed American, Ashkenazi Jewish, and Others. Interestingly, we could find significant differences between the African population and the East Asian population at the single nucleotide polymorphism level of glutamate metabolism genes, but no clear differences were noted in glutamate-sensing genes. These suggest that glutamate-sensing genes are under the functional constraint compared to glutamate metabolism genes.</p><p><strong>Conclusion: </strong>Thus, glutamate-sensing genes and metabolism genes have a contrasting mode of the evolution, and glutamate-sensing genes are conservatively evolved, indicating its functional importance.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"502-510"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89716772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of Life in the Management of Home Parenteral Nutrition. 家庭营养管理中的生活质量。
IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-03-17 DOI: 10.1159/000530082
Katja A Schönenberger, Emilie Reber, Valentina V Huwiler, Christa Dürig, Raphaela Muri, Michèle Leuenberger, Stefan Mühlebach, Zeno Stanga

Introduction: Home parenteral nutrition (HPN) is a rare but challenging therapy for patients with mostly severe underlying diseases. We aimed to investigate patient-reported health-related quality of life (QOL) of patients receiving HPN and its development over time in particular.

Methods: We assessed QOL of HPN patients in a prospective multicenter observational study (SWISSHPN II study). We designed a questionnaire to record symptoms and negative impacts of HPN and completed the validated Optum® SF-36v2® Health Survey with the patients.

Results: Seventy patients (50% women) on HPN were included. HPN commonly affected feelings of dependency (n = 49, 70%), traveling/leaving home (n = 37, 53%), attending cultural and social events (n = 25, 36%), and sleep (n = 22, 31%). Most frequently reported symptoms were diarrhea (n = 30, 43%), polyuria (n = 28, 40%), nausea/emesis (n = 27, 39%), dysgeusia (n = 23, 33%), and cramps (n = 20, 29%). At baseline, mean (standard deviation) SF-36v2® physical and mental health component summary scores (PCS and MCS) were 45 (20) and 57 (19), respectively, and there was a trend toward improvement in PCS over the study period, while MCS remained stable. Satisfaction with health care professionals involved in HPN care was high.

Conclusion: QOL is a crucial and decisive aspect of HPN patient care. Symptoms related to the underlying disease and PN are frequent. Impaired social life and an ambivalent attitude toward the life-saving therapy are major concerns for these patients and should be addressed in their care.

引言:家庭胃肠外营养(HPN)是一种罕见但具有挑战性的治疗方法,适用于大多数严重基础疾病的患者。我们的目的是调查接受HPN的患者报告的健康相关生活质量(QOL),特别是其随时间的发展。方法:我们在一项前瞻性多中心观察性研究(SWISSHPN II研究)中评估了HPN患者的生活质量。我们设计了一份问卷来记录HPN的症状和负面影响,并完成了对患者的经验证的Optum®SF-36v2®健康调查。结果:纳入70例HPN患者(50%为女性)。HPN通常影响依赖感(n=49,70%)、旅行/离家(n=37,53%)、参加文化和社会活动(n=25,36%)以及睡眠(n=22,31%)。最常见的症状是腹泻(n=30,43%)、多尿(n=28,40%)、恶心/呕吐(n=27,39%)、味觉障碍(n=23,33%)和痉挛(n=20,29%)。基线时,SF-36v2®身心健康成分汇总得分(PCS和MCS)的平均值(标准差)分别为45(20)和57(19),在研究期间,PCS有改善的趋势,而MCS保持稳定。对参与HPN护理的卫生保健专业人员的满意度很高。结论:生活质量是HPN患者护理的关键和决定性因素。与潜在疾病和PN相关的症状很常见。受损的社会生活和对拯救生命的疗法的矛盾态度是这些患者的主要担忧,应该在他们的护理中加以解决。
{"title":"Quality of Life in the Management of Home Parenteral Nutrition.","authors":"Katja A Schönenberger,&nbsp;Emilie Reber,&nbsp;Valentina V Huwiler,&nbsp;Christa Dürig,&nbsp;Raphaela Muri,&nbsp;Michèle Leuenberger,&nbsp;Stefan Mühlebach,&nbsp;Zeno Stanga","doi":"10.1159/000530082","DOIUrl":"10.1159/000530082","url":null,"abstract":"<p><strong>Introduction: </strong>Home parenteral nutrition (HPN) is a rare but challenging therapy for patients with mostly severe underlying diseases. We aimed to investigate patient-reported health-related quality of life (QOL) of patients receiving HPN and its development over time in particular.</p><p><strong>Methods: </strong>We assessed QOL of HPN patients in a prospective multicenter observational study (SWISSHPN II study). We designed a questionnaire to record symptoms and negative impacts of HPN and completed the validated Optum® SF-36v2® Health Survey with the patients.</p><p><strong>Results: </strong>Seventy patients (50% women) on HPN were included. HPN commonly affected feelings of dependency (n = 49, 70%), traveling/leaving home (n = 37, 53%), attending cultural and social events (n = 25, 36%), and sleep (n = 22, 31%). Most frequently reported symptoms were diarrhea (n = 30, 43%), polyuria (n = 28, 40%), nausea/emesis (n = 27, 39%), dysgeusia (n = 23, 33%), and cramps (n = 20, 29%). At baseline, mean (standard deviation) SF-36v2® physical and mental health component summary scores (PCS and MCS) were 45 (20) and 57 (19), respectively, and there was a trend toward improvement in PCS over the study period, while MCS remained stable. Satisfaction with health care professionals involved in HPN care was high.</p><p><strong>Conclusion: </strong>QOL is a crucial and decisive aspect of HPN patient care. Symptoms related to the underlying disease and PN are frequent. Impaired social life and an ambivalent attitude toward the life-saving therapy are major concerns for these patients and should be addressed in their care.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 3","pages":"326-333"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10566922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FINUT 2022 Conference Abstracts; October 9-11, 2022. FINUT 2022会议摘要;2022年10月9日至11日。
IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 DOI: 10.1159/000526958

The following document is dedicated to compiling the abstracts of the communications and lectures of the FINUT 2022 Conference. The document comprises 111 abstracts of the guest speakers participating in the scientific symposia and special lectures and more than 230 abstracts for oral and poster communications, representing more than 20 countries. FINUT Conferences seek to open a place for contrasted science shared by the Ibero-American region, a necessary space to open opportunities and to display the research work done in Food and Nutrition. The main objective of the FINUT 2022 Conference is to create a space for the exchange and discussion of ideas related to the main challenges of Food and Nutrition in Iberoamerica, in order to offer solutions aimed at improving the health status of populations, taking into account the impact of social inequalities in the region. The scientific program of the Conference includes 40 parallel symposia, 5 breakfasts with the experts, and 11 special lectures. In this second edition the Conference focused on 4 topics: • Healthy Nutrition in the Life Cycle and Clinical Nutrition • Nutritional Epidemiology and Public Health Challenges in Iberoamerica • Safe, Healthy, Sustainable, and Social Food • Methods and Tools in Nutrition The entity organizing the Conference is the Ibero-American Nutrition Foundation (FINUT) which was established in 2011. FINUT is a non-profit and financially self-supporting entity; our vision is to promote research and training, identify problems of public interest and provide scientific answers; and involve all stakeholders in our cause. We work throughout the year in many scientific virtual activities with a large number of beneficiaries and the FINUT Conferences give us the opportunity to meet them personally. We wish to thank the Organizing, Scientific, and Local Committees for the enthusiasm and commitment dedicated to this conference, our sponsors for trusting us again, and take the opportunity we offer them to contact the most valuable part of our event, the delegates; professionals, academics, clinicians, researchers, and students in the areas of Food, Nutrition, and Health, to whom we also extend our most sincere gratitude. ¡See you at FINUT 2024!

以下文件专门汇编了FINUT 2022年会议的通讯和演讲摘要。该文件包括参加科学专题讨论会和特别讲座的111位嘉宾的摘要,以及代表20多个国家的230多份口头和海报通讯的摘要。FINUT会议寻求为伊比利亚-美洲地区共享的对比科学开辟一个场所,这是一个必要的空间,可以打开机会并展示在粮食和营养方面所做的研究工作。伊比利亚美洲联合会2022年会议的主要目标是创造一个交流和讨论与伊比利亚美洲粮食和营养主要挑战有关的想法的空间,以便提出旨在改善人口健康状况的解决办法,同时考虑到该地区社会不平等的影响。会议的科学计划包括40场平行专题讨论会、5场专家早餐和11场专题讲座。在第二届会议上,会议重点讨论了4个主题:•生命周期中的健康营养和临床营养•伊比利亚美洲的营养流行病学和公共卫生挑战•安全、健康、可持续和社会食品•营养方法和工具。组织会议的实体是2011年成立的伊比利亚美洲营养基金会。FINUT是一个非营利性和财政自给自足的实体;我们的愿景是促进研究和培训,发现公众感兴趣的问题,并提供科学的答案;让所有利益相关者都参与我们的事业。我们全年在许多科学虚拟活动中与大量受益者合作,FINUT会议使我们有机会亲自与他们见面。我们要感谢组织委员会、科学委员会和地方委员会对这次会议的热情和承诺,感谢我们的赞助商再次信任我们,并利用我们提供的机会与我们活动中最有价值的部分——代表们取得联系;食品、营养和健康领域的专业人士、学者、临床医生、研究人员和学生,我们也向他们致以最诚挚的感谢。2024 FINUT再见!
{"title":"FINUT 2022 Conference Abstracts; October 9-11, 2022.","authors":"","doi":"10.1159/000526958","DOIUrl":"https://doi.org/10.1159/000526958","url":null,"abstract":"<p><p>The following document is dedicated to compiling the abstracts of the communications and lectures of the FINUT 2022 Conference. The document comprises 111 abstracts of the guest speakers participating in the scientific symposia and special lectures and more than 230 abstracts for oral and poster communications, representing more than 20 countries. FINUT Conferences seek to open a place for contrasted science shared by the Ibero-American region, a necessary space to open opportunities and to display the research work done in Food and Nutrition. The main objective of the FINUT 2022 Conference is to create a space for the exchange and discussion of ideas related to the main challenges of Food and Nutrition in Iberoamerica, in order to offer solutions aimed at improving the health status of populations, taking into account the impact of social inequalities in the region. The scientific program of the Conference includes 40 parallel symposia, 5 breakfasts with the experts, and 11 special lectures. In this second edition the Conference focused on 4 topics: • Healthy Nutrition in the Life Cycle and Clinical Nutrition • Nutritional Epidemiology and Public Health Challenges in Iberoamerica • Safe, Healthy, Sustainable, and Social Food • Methods and Tools in Nutrition The entity organizing the Conference is the Ibero-American Nutrition Foundation (FINUT) which was established in 2011. FINUT is a non-profit and financially self-supporting entity; our vision is to promote research and training, identify problems of public interest and provide scientific answers; and involve all stakeholders in our cause. We work throughout the year in many scientific virtual activities with a large number of beneficiaries and the FINUT Conferences give us the opportunity to meet them personally. We wish to thank the Organizing, Scientific, and Local Committees for the enthusiasm and commitment dedicated to this conference, our sponsors for trusting us again, and take the opportunity we offer them to contact the most valuable part of our event, the delegates; professionals, academics, clinicians, researchers, and students in the areas of Food, Nutrition, and Health, to whom we also extend our most sincere gratitude. ¡See you at FINUT 2024!</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":"79 1","pages":"49"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10700309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of Nutrition and Metabolism
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1