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Circulating THBS1: A Risk Factor for Nonalcoholic Fatty Liver Disease in Obese Children. 循环THBS1:肥胖儿童非酒精性脂肪肝的危险因素
IF 3.9 3区 医学 Q1 Medicine Pub Date : 2023-01-01 DOI: 10.1159/000527780
Min Li, Lujie Liu, Yurong Kang, Shanlong Huang, Yanfeng Xiao

Introduction: Thrombospondin 1 (THBS1) is a highly expressed adipokine in adults with obesity. In the present study, we aimed to investigate the clinical significance of THBS1in children with obesity and nonalcoholic fatty liver disease (NAFLD) and determine the effect of metformin on THBS1 expression in dietary-induced obese (DIO) mice.

Methods: A cross-sectional study was conducted among 78 obese children and 35 nonobese children. Anthropometric parameters, clinical data, and circulating THBS1 levels were measured. The expression of THBS1 was detected in the serum and liver tissue from diet-induced obese mice (C57BL/6) with or without metformin treatment.

Results: Higher THBS1 levels were observed in children with NAFLD and higher SDS-BMI. Individuals in the higher THBS1 quartile had a higher prevalence of hypo-high-density lipoprotein cholesterol (HDL-C). Logistic regression analysis showed a significant correlation between THBS1 and NAFLD, as well as between hip circumference and leptin levels. Receiver-operating characteristic (ROC) analysis revealed that THBS1 was a more sensitive predictor of NAFLD than leptin. Additionally, metformin ameliorated hepatic steatosis and decreased hepatic THBS1 expression in high-fat diet (HFD)-fed mice.

Conclusions: Circulating THBS1 level may be a risk factor for NAFLD in obese children. Our findings provided a novel approach of metformin administration for the prevention and treatment of NAFLD. This study also confirmed that metformin decreased the expression of hepatic THBS in DIO mice.

血栓反应蛋白1 (THBS1)是一种在成人肥胖患者中高表达的脂肪因子。在本研究中,我们旨在探讨THBS1在肥胖和非酒精性脂肪性肝病(NAFLD)儿童中的临床意义,并确定二甲双胍对饮食性肥胖(DIO)小鼠THBS1表达的影响。方法:对78名肥胖儿童和35名非肥胖儿童进行横断面研究。测量人体测量参数、临床数据和循环THBS1水平。在饮食诱导肥胖小鼠(C57BL/6)的血清和肝组织中检测THBS1的表达。结果:在NAFLD和SDS-BMI较高的儿童中,THBS1水平较高。THBS1水平较高的个体低高密度脂蛋白胆固醇(HDL-C)患病率较高。Logistic回归分析显示THBS1与NAFLD、臀围与瘦素水平有显著相关性。受试者工作特征(ROC)分析显示THBS1比瘦素更敏感地预测NAFLD。此外,二甲双胍改善了高脂肪饮食(HFD)喂养小鼠的肝脏脂肪变性,降低了肝脏THBS1的表达。结论:循环THBS1水平可能是肥胖儿童NAFLD的危险因素。我们的发现为预防和治疗NAFLD提供了一种新的二甲双胍给药方法。本研究也证实二甲双胍降低了DIO小鼠肝脏THBS的表达。
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引用次数: 2
Expression of Concern. 表达关心。
IF 3.9 3区 医学 Q1 Medicine Pub Date : 2023-01-01 DOI: 10.1159/000529287
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引用次数: 0
FINUT 2022 Conference Abstracts; October 9-11, 2022. FINUT 2022 会议摘要;2022 年 10 月 9-11 日。
IF 3.9 3区 医学 Q1 Medicine Pub Date : 2023-01-01 Epub Date: 2022-10-06 DOI: 10.1159/000526958

The following document is dedicated to compiling the abstracts of the communications and lectures of the FINUT 2022 Conference. The document comprises 111 abstracts of the guest speakers participating in the scientific symposia and special lectures and more than 230 abstracts for oral and poster communications, representing more than 20 countries. FINUT Conferences seek to open a place for contrasted science shared by the Ibero-American region, a necessary space to open opportunities and to display the research work done in Food and Nutrition. The main objective of the FINUT 2022 Conference is to create a space for the exchange and discussion of ideas related to the main challenges of Food and Nutrition in Iberoamerica, in order to offer solutions aimed at improving the health status of populations, taking into account the impact of social inequalities in the region. The scientific program of the Conference includes 40 parallel symposia, 5 breakfasts with the experts, and 11 special lectures. In this second edition the Conference focused on 4 topics: • Healthy Nutrition in the Life Cycle and Clinical Nutrition • Nutritional Epidemiology and Public Health Challenges in Iberoamerica • Safe, Healthy, Sustainable, and Social Food • Methods and Tools in Nutrition The entity organizing the Conference is the Ibero-American Nutrition Foundation (FINUT) which was established in 2011. FINUT is a non-profit and financially self-supporting entity; our vision is to promote research and training, identify problems of public interest and provide scientific answers; and involve all stakeholders in our cause. We work throughout the year in many scientific virtual activities with a large number of beneficiaries and the FINUT Conferences give us the opportunity to meet them personally. We wish to thank the Organizing, Scientific, and Local Committees for the enthusiasm and commitment dedicated to this conference, our sponsors for trusting us again, and take the opportunity we offer them to contact the most valuable part of our event, the delegates; professionals, academics, clinicians, researchers, and students in the areas of Food, Nutrition, and Health, to whom we also extend our most sincere gratitude. ¡See you at FINUT 2024!

以下文件汇编了 2022 年 FINUT 会议的交流和讲座摘要。该文件包括111份参加科学研讨会和特别讲座的特邀发言人摘要,以及230多份口头和海报交流摘要,代表了20多个国家。FINUT 会议旨在为伊比利亚-美洲地区共享的对比科学开辟一个空间,一个提供机会和展示食品与营养研究工作的必要空间。FINUT 2022 年会议的主要目标是为伊比利亚-美洲地区食品与营养方面的主要挑战创造一个交流和讨论的空间,以便提供旨在改善人口健康状况的解决方案,同时考虑到该地区社会不平等的影响。会议的科学计划包括 40 场平行专题讨论会、5 场专家早餐会和 11 场特别讲座。在第二届会议上,大会重点讨论了 4 个主题:- 生命周期中的健康营养和临床营养--伊比利亚美洲的营养流行病学和公共卫生挑战--安全、健康、可持续和社会食品--营养方法和工具。 会议的组织机构是成立于 2011 年的伊比利亚美洲营养基金会(FINUT)。伊比利亚-美洲营养基金会是一个非营利性、财政自立的实体;我们的愿景是促进研究和培训,发现公众关心的问题并提供科学答案;让所有利益相关者参与到我们的事业中来。我们全年都在开展许多科学虚拟活动,受益者众多,FINUT 会议为我们提供了与他们会面的机会。我们要感谢组委会、科学委员会和地方委员会对本次会议的热情和投入,感谢赞助商对我们的再次信任,并借此机会与我们活动中最有价值的部分--代表们,即食品、营养和健康领域的专业人士、学者、临床医生、研究人员和学生们取得联系,我们也向他们表示最诚挚的谢意。FINUT 2024 年会再见!
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引用次数: 0
Comparisons of Insulin Resistance- and Steatosis-Based Scores in Monitoring Metabolic Associated Fatty Liver Disease Treatment Response. 胰岛素抵抗和脂肪变性评分在监测代谢相关脂肪肝治疗反应中的比较
IF 3.9 3区 医学 Q1 Medicine Pub Date : 2023-01-01 Epub Date: 2023-09-07 DOI: 10.1159/000530531
Junzhao Ye, Yansong Lin, Congxian Shao, Yanhong Sun, Shiting Feng, Bihui Zhong

Background: Quantitative measurements of liver fat contents (LFCs) by magnetic resonance imaging derived-proton density fat fraction (MRI-PDFF) are accurate but limited by availability, convenience, and expense in the surveillance of metabolic associated fatty liver (MAFLD). Insulin resistance (IR) and steatosis-associated serum indices are useful in screening for MAFLD, but their value in monitoring MAFLD with or without chronic hepatitis B virus (CHB) infection remains unclear and we aimed to evaluate these scores in predicting changes in LFC.

Methods: We conducted a prospective study between January 2015 and December 2021 with 620 consecutive participants with MAFLD (212 participants with CHB) who received a 24-week lifestyle intervention. The homeostasis model assessment of IR (HOMA-IR), HOMA2 index, glucose-insulin ratio, quantitative insulin sensitivity check index, fasting insulin resistance index, fatty liver index (FLI), hepatic steatosis index (HSI), liver fat score (LFS), visceral adiposity index, and triglycerides * glucose were calculated.

Results: When using endpoints such as LFS improvements of ≥5% or 10% or escalations of ≥5%, LFS had the highest area under the curve (AUC) values at all endpoints for MAFLD alone (0.756, 95% CI: 0.707-0.805; 0.761, 95% CI: 0.705-0.818; 0.807, 95% CI: 0.713-0.901, all p < 0.05, respectively). With CHB, the FLI (AUC = 0.750) and HIS (AUC = 0.770) exhibited the highest AUCs between the former two outcomes, respectively, but no score could predict LFC escalation of ≥5%.

Conclusion: Among IR and steatosis scores, changes in LFC through lifestyle interventions can be captured with LFS possessing moderate precision but not in those with CHB.

背景:通过磁共振成像衍生质子密度脂肪分数(MRI-PDFF)定量测量肝脏脂肪含量(LFCs)是准确的,但在代谢相关性脂肪肝(MAFLD)监测中受到可用性、便利性和费用的限制。胰岛素抵抗(IR)和脂肪变性相关的血清指标在筛选MAFLD时是有用的,但它们在监测伴有或不伴有慢性乙型肝炎病毒(CHB)感染的MAFLD中的价值尚不清楚,我们的目的是评估这些评分在预测LFC变化方面的价值。方法:我们在2015年1月至2021年12月期间对620名MAFLD患者(212名CHB患者)进行了一项前瞻性研究,这些患者接受了24周的生活方式干预。计算IR (HOMA-IR)、HOMA2指数、葡萄糖-胰岛素比值、胰岛素定量敏感性检查指数、空腹胰岛素抵抗指数、脂肪肝指数(FLI)、肝脂肪变性指数(HSI)、肝脂肪评分(LFS)、内脏脂肪指数、甘油三酯*葡萄糖等稳态模型评价。结果:当使用LFS改善≥5%或10%或升高≥5%等终点时,LFS在所有终点的曲线下面积(AUC)值仅为MAFLD时最高(0.756,95% CI: 0.707-0.805;0.761, 95% ci: 0.705-0.818;0.807, 95% CI: 0.713-0.901,均p <分别为0.05)。对于CHB, FLI (AUC = 0.750)和HIS (AUC = 0.770)在前两种结果之间分别表现出最高的AUC,但没有评分可以预测LFC升级≥5%。结论:在IR和脂肪变性评分中,通过生活方式干预的LFC变化可以用LFS来捕捉,LFS具有中等精度,但在CHB患者中则没有。
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引用次数: 0
Expression of Concern. 表达关心。
IF 3.9 3区 医学 Q1 Medicine Pub Date : 2023-01-01 DOI: 10.1159/000529290
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引用次数: 0
Promoting Breastfeeding and Interaction of Paediatric Associations with Commercial Providers of Nutritional Products: Are They Compatible? 促进母乳喂养以及儿科协会与营养产品商业供应商的互动:它们兼容吗?
IF 3.9 3区 医学 Q1 Medicine Pub Date : 2023-01-01 Epub Date: 2023-01-23 DOI: 10.1159/000529217
Berthold Koletzko, Mary Fewtrell, Adamos Hadjipanayis
None (editorial).
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引用次数: 0
Erratum. 勘误表。
IF 3.9 3区 医学 Q1 Medicine Pub Date : 2023-01-01 Epub Date: 2023-08-22 DOI: 10.1159/000533239
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引用次数: 0
Explorative Clustering of the Nitrogen Balance Trajectory in Critically Ill Patients: A Preliminary post hoc Analysis of a Single-Center Prospective Observational Study. 危重患者氮平衡轨迹的探索性聚类:单中心前瞻性观察性研究的初步事后分析。
IF 3.9 3区 医学 Q1 Medicine Pub Date : 2023-01-01 Epub Date: 2023-10-09 DOI: 10.1159/000532126
Kensuke Nakamura, Kentaro Ogura, Hidehiko Nakano, Daisuke Ikechi, Masaki Mochizuki, Yuji Takahashi, Tadahiro Goto

Background: The nitrogen balance estimates a protein net difference. However, since it has a number of limitations, it is important to consider the trajectory of the nitrogen balance in the clinical course of critically ill patients.

Objectives: We herein exploratively classified the nitrogen balance trajectory using a machine learning method.

Method: This is a post hoc analysis of a single-center prospective study for the patients admitted to our Emergency and Critical Center ICU. The nitrogen balance was evaluated with 24-h urine collection from ICU days 1-10 with 9 points. K-means clustering was performed to classify the nitrogen balance trajectory. We also evaluated factors associated with uncovered clusters.

Results: Seventy-six eligible patients were included in the present study. After clustering, the nitrogen balance trajectory was classified into 4 classes. Class 1 was trajected as a negative balance over 10 days (24 patients). Class 2 had a positive conversion on day 3 or 4 (8 patients). Class 3 had a positive conversion on day 8 or 9 (28 patients). Class 4 initially had a positive balance and then converted to a negative balance (16 patients). Sepsis complication and steroid use were associated with negative nitrogen balance trajectory. Class 2 was associated with lower length of hospital stay and femoral muscle volume loss, however, frequently had frailty and sarcopenia on admission. Active nutrition therapy intention was not correlated with positive trajectory.

Conclusions: The nitrogen balance trajectory in critically ill patients may be classified into 4 classes for clinical practice. Among patients emergently admitted to the ICU, the positive conversion of the nitrogen balance might be delayed over 10 days.

背景:氮平衡估计蛋白质净差异。然而,由于它有许多局限性,在危重患者的临床过程中考虑氮平衡的轨迹是很重要的。目的:本文采用机器学习方法对氮平衡轨迹进行了探索性分类。方法:这是对我们急诊和危重症中心ICU患者的单中心前瞻性研究的事后分析。氮平衡通过ICU第1天至第10天的24小时尿液采集进行评估,得9分。采用K-means聚类对氮平衡轨迹进行分类。我们还评估了与未覆盖集群相关的因素。结果:76名符合条件的患者被纳入本研究。聚类后,将氮平衡轨迹分为4类。在10天内(24名患者),将1类作为负平衡。2级在第3或第4天出现阳性转化(8名患者)。3级在第8天或第9天出现阳性转化(28名患者)。第4类最初为正平衡,然后转为负平衡(16名患者)。脓毒症并发症和类固醇使用与负氮平衡轨迹相关。2级与住院时间较短和股肌体积减少有关,但入院时经常出现虚弱和少肌症。积极营养治疗意向与阳性轨迹无相关性。结论:危重患者的氮平衡轨迹可分为4类,用于临床实践。在紧急入住ICU的患者中,氮平衡的正转换可能会延迟10天以上。
{"title":"Explorative Clustering of the Nitrogen Balance Trajectory in Critically Ill Patients: A Preliminary post hoc Analysis of a Single-Center Prospective Observational Study.","authors":"Kensuke Nakamura, Kentaro Ogura, Hidehiko Nakano, Daisuke Ikechi, Masaki Mochizuki, Yuji Takahashi, Tadahiro Goto","doi":"10.1159/000532126","DOIUrl":"10.1159/000532126","url":null,"abstract":"<p><strong>Background: </strong>The nitrogen balance estimates a protein net difference. However, since it has a number of limitations, it is important to consider the trajectory of the nitrogen balance in the clinical course of critically ill patients.</p><p><strong>Objectives: </strong>We herein exploratively classified the nitrogen balance trajectory using a machine learning method.</p><p><strong>Method: </strong>This is a post hoc analysis of a single-center prospective study for the patients admitted to our Emergency and Critical Center ICU. The nitrogen balance was evaluated with 24-h urine collection from ICU days 1-10 with 9 points. K-means clustering was performed to classify the nitrogen balance trajectory. We also evaluated factors associated with uncovered clusters.</p><p><strong>Results: </strong>Seventy-six eligible patients were included in the present study. After clustering, the nitrogen balance trajectory was classified into 4 classes. Class 1 was trajected as a negative balance over 10 days (24 patients). Class 2 had a positive conversion on day 3 or 4 (8 patients). Class 3 had a positive conversion on day 8 or 9 (28 patients). Class 4 initially had a positive balance and then converted to a negative balance (16 patients). Sepsis complication and steroid use were associated with negative nitrogen balance trajectory. Class 2 was associated with lower length of hospital stay and femoral muscle volume loss, however, frequently had frailty and sarcopenia on admission. Active nutrition therapy intention was not correlated with positive trajectory.</p><p><strong>Conclusions: </strong>The nitrogen balance trajectory in critically ill patients may be classified into 4 classes for clinical practice. Among patients emergently admitted to the ICU, the positive conversion of the nitrogen balance might be delayed over 10 days.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10711758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Take-Home Messages from 20 Years of Progress in Dietary Therapy of Inflammatory Bowel Disease. 把20年来炎症性肠病饮食治疗进展的信息带回家。
IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-11-09 DOI: 10.1159/000535007
Konstantinos Gkikas, Vaios Svolos, Richard Hansen, Richard K Russell, Konstantinos Gerasimidis

Background: A significant body of literature has interrogated the critical role of diet in the development and management of inflammatory bowel disease (IBD).

Summary: This review provides a summary and critical appraisal of the literature in this area, focussing on four distinct themes: nutritional epidemiology, animal and in vitro experiments, enteral nutrition, and food-based dietary therapies.

Key messages: Nutritional epidemiology and data from experiments in animals indicate that a western-type diet pattern is associated with increased risk of IBD onset. However, these findings have not been consistently replicated in the dietary management of IBD. Exclusive enteral nutrition (EEN) is the only dietary therapy with reproducible evidence of efficacy in the management of active Crohn's disease (CD). Use of EEN may also be useful for improving perioperative outcomes in CD, and as an adjuvant therapy to biologic therapy. Several dietary therapies for CD and ulcerative colitis have been proposed in the literature, but replication in well-controlled studies is needed before their routine use enters the clinical setting. Precision nutritional therapy might be an attractive therapeutic paradigm in a heterogenous disease like IBD. However, no recommendations for personalised dietary therapy can currently be made, and it is imperative we unravel the complex interplay between diet and gut inflammation before we are able to do so. Undoubtedly, diet is of critical importance in the development and management of IBD. However, the exact mechanism by which diet causes gut inflammation is still elusive, and dietary guidance is difficult to formulate.

背景:大量文献对饮食在炎症性肠病(IBD)的发展和管理中的关键作用进行了质疑。摘要:这篇综述对该领域的文献进行了总结和批判性评价,重点关注四个不同的主题:营养流行病学、动物和体外实验、肠内营养和基于食物的饮食疗法。关键信息:营养流行病学和动物实验数据表明,西方饮食模式与IBD发病风险增加有关。然而,这些发现并没有在IBD的饮食管理中得到一致的复制。纯肠内营养(EEN)是唯一一种在治疗活动性克罗恩病(CD)方面具有可重复疗效的饮食疗法。EEN的使用也可能有助于改善CD的围手术期结果,并作为生物治疗的辅助治疗。文献中已经提出了几种治疗CD和溃疡性结肠炎的饮食疗法,但在常规使用进入临床环境之前,需要在控制良好的研究中进行复制。精确营养治疗对于像IBD这样的异质性疾病可能是一种有吸引力的治疗模式。然而,目前还没有关于个性化饮食治疗的建议,在我们能够做到这一点之前,我们必须先弄清饮食和肠道炎症之间的复杂相互作用。毫无疑问,饮食在IBD的发展和管理中至关重要。然而,饮食引起肠道炎症的确切机制仍然难以捉摸,饮食指南也很难制定。
{"title":"Take-Home Messages from 20 Years of Progress in Dietary Therapy of Inflammatory Bowel Disease.","authors":"Konstantinos Gkikas, Vaios Svolos, Richard Hansen, Richard K Russell, Konstantinos Gerasimidis","doi":"10.1159/000535007","DOIUrl":"10.1159/000535007","url":null,"abstract":"<p><strong>Background: </strong>A significant body of literature has interrogated the critical role of diet in the development and management of inflammatory bowel disease (IBD).</p><p><strong>Summary: </strong>This review provides a summary and critical appraisal of the literature in this area, focussing on four distinct themes: nutritional epidemiology, animal and in vitro experiments, enteral nutrition, and food-based dietary therapies.</p><p><strong>Key messages: </strong>Nutritional epidemiology and data from experiments in animals indicate that a western-type diet pattern is associated with increased risk of IBD onset. However, these findings have not been consistently replicated in the dietary management of IBD. Exclusive enteral nutrition (EEN) is the only dietary therapy with reproducible evidence of efficacy in the management of active Crohn's disease (CD). Use of EEN may also be useful for improving perioperative outcomes in CD, and as an adjuvant therapy to biologic therapy. Several dietary therapies for CD and ulcerative colitis have been proposed in the literature, but replication in well-controlled studies is needed before their routine use enters the clinical setting. Precision nutritional therapy might be an attractive therapeutic paradigm in a heterogenous disease like IBD. However, no recommendations for personalised dietary therapy can currently be made, and it is imperative we unravel the complex interplay between diet and gut inflammation before we are able to do so. Undoubtedly, diet is of critical importance in the development and management of IBD. However, the exact mechanism by which diet causes gut inflammation is still elusive, and dietary guidance is difficult to formulate.</p>","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening for Inflammatory Markers Identifies IL-18Rα as a Potential Link between Exenatide and Its Anti-Inflammatory Effect: New Results from the Combat-JUDO Randomized Controlled Trial. 炎症标志物的筛选确定IL18-Rα是艾塞那肽及其抗炎作用之间的潜在联系。战斗JUDO随机对照试验的新结果。
IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-01 Epub Date: 2023-10-26 DOI: 10.1159/000534725
Rasmus Stenlid, Sara Y Cerenius, Hannes Manell, Banu Küçükemre Aydin, Katharina Mörwald, Julian Gomahr, Marina Höghammar Mitkas, Ida Eriksson, Iris Ciba, Sabine Geiersberger, David Thivel, Daniel Weghuber, Peter Bergsten, Anders Forslund

Introduction: Obesity is associated with chronic inflammation. Chronic inflammation has also been linked to insulin resistance and type 2 diabetes, metabolic associated fatty liver disease, and cardiovascular disease. Glucagon-like peptide-1 (GLP-1) receptor analogs (GLP-1RA) are clinically used to treat obesity, with known anti-inflammatory properties. How the GLP-1RA exenatide effects inflammation in adolescents with obesity is not fully investigated.

Methods: Forty-four patients were randomized to receive weekly subcutaneous injections with either 2 mg exenatide or placebo for 6 months. Plasma samples were collected at baseline and at the end of the study, and 92 inflammatory proteins were measured.

Results: Following treatment with exenatide, 15 out of the 92 proteins were decreased, and one was increased. However, after adjustment for multiple testing, only IL-18Rα was significantly lowered following treatment.

Conclusions: Weekly injections with 2 mg of exenatide lowers circulating IL-18Rα in adolescents with obesity, which may be a potential link between exenatide and its anti-inflammatory effect in vivo. This contributes to exenatide's pharmaceutical potential as a treatment for obesity beyond weight control and glucose tolerance, and should be further studied mechanistically.

简介:肥胖与慢性炎症有关。慢性炎症也与胰岛素抵抗、2型糖尿病、非酒精性脂肪肝和心血管疾病有关。胰高血糖素样肽-1(GLP-1)受体类似物(GLP-1RA)在临床上用于治疗肥胖,具有已知的抗炎特性。GLP-1RA艾塞那肽如何影响肥胖青少年的炎症尚未得到充分研究。方法:44名患者随机接受每周皮下注射2 mg艾塞那肽或安慰剂,为期6个月。在基线和研究结束时采集血浆样本,并测量90种炎症蛋白。结果:艾塞那肽治疗后,90种蛋白质中有15种减少,1种增加。然而,在对多项测试进行调整后,只有IL18-Rα在治疗后显著降低。结论:每周注射2 mg艾塞那肽可降低肥胖青少年的循环IL18-Rα,这可能是艾塞那苷与其体内抗炎作用之间的潜在联系。这有助于艾塞那肽作为治疗体重控制和糖耐量之外的肥胖的药物潜力,应该进一步进行机制研究。
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引用次数: 0
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Annals of Nutrition and Metabolism
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