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Relation of Serum 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Level to Hematological Examination Results in Veterans of Operation Ranch Hand 牧场手作战退伍军人血清2,3,7,8-四氯二苯并对二恶英(TCDD)水平与血液学检查结果的关系
Pub Date : 2001-09-01 DOI: 10.1080/00039890109604474
J. Michalek, F. Akhtar, M. Longnecker, Joseph E. Burton
Abstract The authors studied indices of hematologic function and exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Vietnam War veterans of Operation Ranch Hand–the Air Force unit responsible for the aerial spraying of Agent Orange and other herbicides in Vietnam. The herbicides were contaminated with TCDD. The authors measured TCDD serum levels in 1987 or later and extrapolated the result to the time of service in Vietnam. The authors studied serum TCDD level in relation to red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, white blood cell count, platelet count, and erythrocyte sedimentation rate at each of 4 physical examinations. Compared with veterans not involved in Operation Ranch Hand, those with the highest TCDD levels in Operation Ranch Hand had mean corpuscular volumes that were about 1 % higher and platelet counts that were about 4% higher. These small increases were unlikely to be of clinical significance and may not have been caused by TCDD.
摘要:作者研究了在越战中负责空中喷洒橙剂和其他除草剂的空军“牧场之手”行动的退伍军人的血液功能指标和接触2,3,7,8-四氯二苯并对二恶英(TCDD)的情况。除草剂被TCDD污染。作者测量了1987年或之后的TCDD血清水平,并将结果推断为在越南服役的时间。作者研究了4次体检中血清TCDD水平与红细胞计数、血红蛋白、红细胞压积、平均红细胞体积、白细胞计数、血小板计数和红细胞沉降率的关系。与未参加“牧场之手”行动的退伍军人相比,那些TCDD水平最高的退伍军人的平均红细胞体积约高1%,血小板计数约高4%。这些微小的增加不太可能具有临床意义,也可能不是由TCDD引起的。
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引用次数: 11
Health Evaluation of Volatile Organic Compound (VOC) Emissions from Wood and Wood-Based Materials 木材和木基材料挥发性有机化合物(VOC)排放的健康评价
Pub Date : 2001-09-01 DOI: 10.1080/00039890109604477
L. Jensen, Annelise Larsen, L. Mølhave, M. K. Hansen, Bodil Knudsen
Abstract In this study, the authors describe a method for evaluation of material emissions. The study was based on chemical analysis of emissions from 23 materials representing solid wood and wood-based materials commonly used in furniture, interior furnishings and building products in Denmark in the 1990s. The authors used the emission chamber testing method to examine the selected materials with a qualitative screening and quantitative determination of volatile organic compounds. The authors evaluated the toxicological effects of all substances identified with chamber testing. Lowest concentration of interest and standard room concentrations were assessed and the authors calculated an S-value for each wood and wood-based material. The authors identified 144 different chemical substances with the screening analyses and a total of 84 individual substances were quantified with chamber measurements. The irritative effects dominated at low exposure levels; therefore, the lowest concentration of interest and the S-value were based predominantly on these effects. The S-values were very low for solid ash, oak and beech. For solid spruce and pine, the determining substances for size of the S-value were Δ3-carene, α-pinene and limonene. For the surface-treated wood materials, the S-value reflected the emitted substances from the surface treatment.
在本研究中,作者描述了一种评估材料排放的方法。这项研究是基于对20世纪90年代丹麦家具、室内陈设和建筑产品中常用的23种实木和木基材料的化学分析。采用排放室法对所选材料进行定性筛选和挥发性有机物定量测定。作者评估了通过室内试验确定的所有物质的毒理学效应。评估了最低兴趣浓度和标准房间浓度,并计算了每种木材和木基材料的s值。作者通过筛选分析确定了144种不同的化学物质,并通过室内测量对84种单独的物质进行了量化。低暴露水平下的刺激效应占主导地位;因此,兴趣的最低集中度和s值主要基于这些效应。固体灰、橡树和山毛榉的s值很低。对于固体云杉和松木,s值大小的决定物质为Δ3-carene、α-蒎烯和柠檬烯。对于表面处理过的木质材料,s值反映了表面处理发出的物质。
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引用次数: 78
Respiratory Symptoms and Pulmonary Function among Traffic Police in Bangkok, Thailand 泰国曼谷交通警察的呼吸症状和肺功能
Pub Date : 2001-09-01 DOI: 10.1080/00039890109604484
K. Karita, E. Yano, W. Jinsart, Doungrutai Boudoung, K. Tamura
Abstract The authors undertook a cross-sectional study of the potential adverse health effects of air pollution in Bangkok, Thailand. During 1998 and 1999, the authors administered lung function spirometry tests and a Thai version of the American Thoracic Society's Division of Lung Diseases (ATS-DLD) respiratory questionnaire to 78 male traffic police and 60 male nontraffic police in Bangkok, as well as to 68 male general police in Ayutthaya province, a rural area in Thailand. No consistent trend of decreased pulmonary function was observed in traffic police. The authors controlled for age, height and smoking index, after which mean levels of forced expiratory volume in 1 sec and maximal expiratory flow rate in 25% of vital capacity ([Vdot]25) were significantly lower in Bangkok police than in Ayutthaya police. The prevalence of respiratory symptoms among Bangkok police was slightly higher than among Ayutthaya police. Multiple regression analysis identified age and workplace as statistically significant factors that contributed to the values of forced expiratory volume in 1 sec and [Vdot]25. This study provided some evidence of an increase in prevalence of obstructive changes in the peripheral airways among traffic police in Bangkok.
作者对泰国曼谷空气污染的潜在不良健康影响进行了横断面研究。在1998年和1999年期间,作者对曼谷的78名男性交通警察和60名男性非交通警察以及泰国农村大城府的68名男性普通警察进行了肺功能肺活量测定和泰国版的美国胸科学会肺病科(ATS-DLD)呼吸问卷调查。交警肺功能下降趋势不一致。作者控制了年龄、身高和吸烟指数,之后,曼谷警察1秒内强迫呼气量的平均水平和25%肺活量的最大呼气流量([Vdot]25)显著低于大城警察。曼谷警察的呼吸道症状患病率略高于大城府警察。多元回归分析发现,年龄和工作场所是影响1秒用力呼气量和[Vdot]25值的有统计学意义的因素。这项研究提供了一些证据,表明曼谷交通警察周围气道阻塞性变化的患病率有所增加。
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引用次数: 52
Decreases of Natural Killer Cells and T-Lymphocyte Subpopulations and Increases of B Lymphocytes Following a 5-Day Occupational Exposure to Mixed Organic Solvents 职业性接触混合有机溶剂5天后自然杀伤细胞和t淋巴细胞亚群减少,B淋巴细胞增加
Pub Date : 2001-09-01 DOI: 10.1080/00039890109604480
T. Tanigawa, S. Araki, A. Nakata, K. Yokoyama, T. Sakai, S. Sakurai
Abstract The authors examined the effects of organic solvents on lymphocyte subpopulations in blood. Natural killer and T-lymphocyte subpopulations and B (CD19+) -lymphocytes were measured with flow cytometry in 16 male rotogravure printers on a Friday and on the following Monday. Numbers of all 3 subpopulations of natural killer cells (i.e., CD57+ CD16+, CD57-CD16+ and CD57+CD16- cells), 2 subpopulations of T lymphocytes (CD4+ CD45RA+ and total CD8+ cells) and total lymphocytes on Friday were significantly fewer than those found on the following Monday. Conversely, the number of B lymphocytes on Friday was significantly larger than the number on Monday. The number of B lymphocytes was significantly correlated with blood toluene levels on Friday. The alteration in the number of CD57+CD16+ NK cells from Friday to the following Monday was correlated inversely with the corresponding change in exposure level of toluene on Friday. The authors suggest that the effects of mixed organic solvents (primarily toluene) are recoverable decreases of natural killer cells and T lymphocytes and increases in B lymphocytes.
作者研究了有机溶剂对血液中淋巴细胞亚群的影响。用流式细胞术检测了16名男性凹版印刷工人的自然杀伤细胞、t淋巴细胞亚群和B (CD19+)淋巴细胞。自然杀伤细胞的3个亚群(CD57+CD16 +、CD57-CD16+和CD57+CD16-细胞)、T淋巴细胞的2个亚群(CD4+ CD45RA+和总CD8+细胞)和总淋巴细胞在周五的数量明显少于周一。相反,周五的B淋巴细胞数量明显大于周一。周五B淋巴细胞数量与血甲苯水平显著相关。周五至下周一CD57+CD16+ NK细胞数量的变化与周五相应的甲苯暴露水平变化呈负相关。作者认为,混合有机溶剂(主要是甲苯)的影响是自然杀伤细胞和T淋巴细胞的可恢复性减少和B淋巴细胞的增加。
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引用次数: 19
Dietary and Clastogenic Factors in Children Who Immigrated to Israel from Regions Contaminated by the Chernobyl Accident 从切尔诺贝利事故污染地区移民到以色列儿童的饮食和致裂因素
Pub Date : 2001-07-01 DOI: 10.1080/00039890109604463
E. Kordysh, I. Emerit, J. Goldsmith, L. Merkin, M. Quastel, A. Bolotin, M. Friger
Abstract The authors evaluated the possible association between dietary history and plasma clastogenic factors in children who immigrated to Israel between 1989 and 1993 from regions contaminated by the Chernobyl accident. The authors compared questionnaire data about demographic variables, dietary histories before and after immigration occurred, and health status with clastogenic factor scores for 162 immigrants. Logistic regression analysis revealed a negative association between clastogenic factor scores and frequency of consumption of fresh vegetables and fruit among children ≤ 7 yr of age during the postimmigration period. Intake of eggs and fish by boys who were ≤ 7 yr of age prior to immigration was associated positively with clastogenic factor scores. Consumption of fresh vegetables and fruits afforded protection to the immune systems of children who were ≤ 7 yr of age.
作者评估了1989年至1993年间从切尔诺贝利事故污染地区移民到以色列的儿童的饮食史与血浆致裂因子之间的可能关联。作者比较了162名移民的人口统计变量、移民前后的饮食史以及健康状况与致裂因子得分的问卷数据。Logistic回归分析显示,移民后时期≤7岁儿童的致裂因子得分与新鲜蔬菜和水果的食用频率呈负相关。移民前≤7岁男孩的鸡蛋和鱼摄入量与致裂因子评分呈正相关。食用新鲜蔬菜和水果可以保护7岁以下儿童的免疫系统。
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引用次数: 7
Call for Papers/Directions for A.E.H. Contributors A.E.H.投稿人征文/指南
Pub Date : 2001-07-01 DOI: 10.1080/00039890109604459
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引用次数: 0
Relationships between Nitrogen Dioxide Personal Exposure and Ambient Air Monitoring Measurements among Children in Three French Metropolitan Areas: VESTA Study 法国三个大城市儿童二氧化氮个人暴露与环境空气监测测量之间的关系:VESTA研究
Pub Date : 2001-07-01 DOI: 10.1080/00039890109604465
Stéphanie Cauvin, Y. Moullec, F. Brémont, I. Momas, F. Balducci, Florence Ciognard, Marie-Pierre Poilve, D. Zmirou, Vesta Investigators
Abstract In epidemiological studies, investigators have routinely used ambient air concentrations, measured by air-quality monitoring networks, to assess exposure of subjects. When there is great spatial variability of ambient air concentrations or when there are specific indoor exposures, this approach may yield substantial exposure misclassification and distort the associations between exposure and the health endpoints of interest. In 3 French metropolitan areas, the cross-sectional relationships between 48 hr of nitrogen dioxide personal exposure of 73 children and the corresponding 48-hr background ambient air concentrations were analyzed. The crude correlation between ambient air concentrations and personal exposures was poor in all cities (r 2 = .009 for Grenoble, r 2 = .04 for Toulouse, and r 2 = .02 for Paris). These correlations were improved when the authors took into account other ambient air or indoor air sources of nitrogen dioxide emissions (the corresponding multiple linear regression, r 2, increased to .43 in Grenoble, .50 in Toulouse, and .37 in Paris). The main variables that explained personal exposures were an index of traffic intensity and proximity and use of a gas cooker at home. The results of this study confirm that ambient air-monitoring site measurements are poor predictors of personal exposure. Investigators should carefully characterize the proximity of roads occupied by dense traffic to the home/school as well as indoor sources of nitric oxide emissions; both of these careful characterizations will assist researchers in the prediction of personal exposure in epidemiological studies.
在流行病学研究中,调查人员通常使用空气质量监测网络测量的环境空气浓度来评估受试者的暴露情况。当环境空气浓度存在很大的空间变异性或存在特定的室内暴露时,这种方法可能导致严重的暴露错误分类,并扭曲暴露与所关注的健康终点之间的关联。在法国3个大都市地区,分析了73名儿童48小时二氧化氮个人暴露与相应的48小时背景环境空气浓度之间的横断面关系。所有城市的环境空气浓度与个人暴露之间的粗相关性都很差(格勒诺布尔的r 2 = 0.009,图卢兹的r 2 = 0.04,巴黎的r 2 = 0.02)。当作者考虑到其他环境空气或室内空气源的二氧化氮排放时,这些相关性得到了改善(相应的多元线性回归,r2在格勒诺布尔增加到0.43,在图卢兹增加到0.50,在巴黎增加到0.37)。解释个人暴露的主要变量是交通强度指数、距离指数和家中燃气灶的使用指数。本研究的结果证实,环境空气监测点的测量结果不能很好地预测个人暴露。调查人员应仔细描述交通密集的道路与家庭/学校以及室内一氧化氮排放源的接近程度;这两种仔细的特征描述将有助于研究人员在流行病学研究中预测个人暴露。
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引用次数: 24
Distribution of Volatile Organic Compounds in Ambient Air of Tehran 德黑兰空气中挥发性有机化合物的分布
Pub Date : 2001-07-01 DOI: 10.1080/00039890109604472
A. Bahrami
Abstract Transportation sources have created a major hydrocarbon pollution problem in the ambient air of Tehran. The authors used a Carbotrap tube to determine volatile organic compounds in air. Such compounds can be desorbed thermally and analyzed with gas chromatography-mass spectrometry. Samples were obtained from 8 sites in Tehran at which traffic flow varied between 500 and 2,500 vehicles/hr. A total of 54 hydrocarbons were identified in the ambient air of Tehran, and the average measured concentrations of benzene, toluene, m- and p-xylene, ethyl benzene, and o-xylene were 127.6 μg/m3, 201.1 μg/m3, 110.7 μg/m3, 58.1 μg/m3, and 57.6 μg/m3, respectively (standard deviation = 3.8–51.7 μg/m3). Emissions of individual pollutants in south Tehran exceeded those in north Tehran, and these emissions were higher during the afternoon than during the morning. The geographical parameters and the photochemical reaction also played important roles in the pollution conditions.
交通来源造成了德黑兰周围空气中主要的碳氢化合物污染问题。作者使用碳捕集器管来测定空气中的挥发性有机化合物。这些化合物可以通过热解吸和气相色谱-质谱分析。从德黑兰的8个地点获得样本,这些地点的交通流量在500至2,500辆/小时之间。德黑兰市区环境空气中共检出54种碳氢化合物,其中苯、甲苯、间二甲苯和对二甲苯、乙苯和邻二甲苯的平均测定浓度分别为127.6 μg/m3、201.1 μg/m3、110.7 μg/m3、58.1 μg/m3和57.6 μg/m3,标准差为3.8 ~ 51.7 μg/m3。德黑兰南部的单项污染物排放量超过了德黑兰北部,而且下午的排放量高于上午。地理参数和光化学反应对污染条件也有重要影响。
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引用次数: 36
Effects of Temperature and Humidification in the Office Environment 温度和湿度对办公环境的影响
Pub Date : 2001-07-01 DOI: 10.1080/00039890109604469
L. M. Reinikainen, J. Jaakkola
Abstract In this investigation, the authors evaluated the relationship between temperature and (a) Sick Building Syndrome symptoms and (b) workers' perceptions of air dryness in environments with and without humidification. The authors studied the average intensity of symptoms and perceptions of dry air relative to room temperature in humidified and nonhumidified conditions. During the 6 wk of the experiment, 2 wings of the building were humidified one-by-one for 1 wk, followed by a week without humidification. A total of 230 daily questionnaires were completed during the nonhumidified period, and 233 were completed during the humidified period. The results were analyzed with linear regression analysis, and the average intensity of dryness symptoms and sensations of dryness increased with each unit increase in temperature above 22 °C, both in the humidified and nonhumidified conditions. Sick Building Syndrome symptoms increased relative only to temperature during the period of no humidification. In conclusion, temperatures above 22 °C caused increased dryness symptoms and a sensation of dryness, independent of humidification. The overall intensity of Sick Building Syndrome symptoms increased only when indoor air was not humidified.
在这项调查中,作者评估了温度与(a)病态建筑综合征症状和(b)工人在加湿和不加湿环境中对空气干燥的感知之间的关系。作者研究了在加湿和非加湿条件下相对于室温的干燥空气的症状和感觉的平均强度。在实验的6周内,对建筑物的两翼进行逐一加湿1周,然后进行不加湿1周。在非加湿期共完成230份日常问卷,在加湿期完成233份。对结果进行线性回归分析,在加湿和非加湿条件下,温度高于22℃时,干燥症状和干燥感觉的平均强度随温度每单位升高而增加。在无加湿期间,病态建筑综合征症状仅相对于温度增加。总之,高于22°C的温度会增加干燥症状和干燥感,与加湿无关。只有当室内空气不加湿时,病态建筑综合征症状的总体强度才会增加。
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引用次数: 63
Short-Term Effects of Air Pollution on Mortality in the Cities of Rouen and Le Havre, France, 1990–1995 1990-1995年法国鲁昂和勒阿弗尔市空气污染对死亡率的短期影响
Pub Date : 2001-07-01 DOI: 10.1080/00039890109604464
A. Zeghnoun, P. Czernichow, P. Beaudeau, A. Hautemanière, L. Froment, A. Tertre, P. Quénel
Abstract In this study, the authors examined the short-term effects of ambient air pollution on mortality across 2 French cities: Rouen and Le Havre. In Poisson regression models, which controlled for day-of-week effects, the authors used nonparametric smoothing to control for temporal trend, weather, and influenza epidemics. In Rouen, an interquartile range increase of 60.5–94.1 μg/m3 of ozone was associated with an increase of 4.1 % (95% confidence interval = 0.6, 7.8) of total mortality. Daily variations in sulfur dioxide (interquartile range increase = 17.6–36.4 μg/m3) were also associated with an 8.2% increase (95% confidence interval = 0.4, 16.6) in respiratory mortality. An increase of 6.1% (95% confidence interval = 1.5, 10.9) of cardiovascular mortality was also observed with an interquartile range increase of nitrogen dioxide (i.e., 25.3–42.2 μg/m3). With respect to Le Havre, an interquartile range increase in daily levels of sulfur dioxide (11.3–35.6 μg/m3) was associated with an increase of approximately 3% (95% confidence interval = 0.8, 5) of cardiovascular mortality. For particulate matter less than or equal to 13 urn in diameter (interquartile increase = 21.5, 45.4 μg/m3), an increase of 6.2% (95% confidence interval = 0.1,12.8) was observed. The estimates of pollutant effects and their standard deviations were slightly affected by the degree of smoothing temporal variations in this study. When low collinearity was present, the 2-pollutant models provided acceptable estimates of pollutant effects. They suggested that the ozone effect was independent of the Black Smoke effect, and that the effects of sulfur dioxide and nitrogen dioxide were unlikely to be confounded by ozone concentrations. However, high collinearity leads to large estimates of the pollutant coefficient variances and, therefore, leads to inaccurate estimates of pollutant effects. The analysis of the contributory effects of different pollutant mixtures requires further investigation in those instances in which high collinearity between pollutants is present.
在这项研究中,作者调查了法国鲁昂和勒阿弗尔两个城市环境空气污染对死亡率的短期影响。在泊松回归模型中,作者使用非参数平滑来控制时间趋势、天气和流感流行。在鲁昂,臭氧浓度每增加60.5-94.1 μg/m3,总死亡率就会增加4.1%(95%可信区间= 0.6,7.8)。二氧化硫的日变化(四分位数范围增加= 17.6-36.4 μg/m3)也与呼吸系统死亡率增加8.2%(95%可信区间= 0.4,16.6)相关。随着二氧化氮浓度(25.3-42.2 μg/m3)的四分位数范围增加,心血管死亡率也增加了6.1%(95%可信区间= 1.5,10.9)。就勒阿弗尔而言,每日二氧化硫水平的四分位数范围(11.3-35.6 μg/m3)增加与心血管死亡率增加约3%(95%置信区间= 0.8,5)相关。对于直径小于或等于13缸的颗粒物(四分位数增幅分别为21.5、45.4 μg/m3),增幅为6.2%(95%可信区间分别为0.1、12.8)。在本研究中,污染物效应的估计及其标准差受到平滑时间变化程度的轻微影响。当存在低共线性时,两种污染物模型提供了可接受的污染物影响估计。他们认为,臭氧效应独立于黑烟效应,二氧化硫和二氧化氮的影响不太可能与臭氧浓度相混淆。然而,高共线性导致对污染物系数方差的估计较大,因此导致对污染物影响的估计不准确。在污染物之间存在高度共线性的情况下,对不同污染物混合物的促成效应的分析需要进一步调查。
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引用次数: 25
期刊
Archives of Environmental Health: An International Journal
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