Pub Date : 2023-12-22DOI: 10.33696/gastroenterology.4.047
N. Machado, Juliana Tedesco Dias, Gabriela Nascimento Hercos, Thabata Koester Weber, Mary de Assis Carvalho
Functional constipation (FC) has a pooled world prevalence of 9.5%, a clear definition by Rome IV Criteria, and the NAPGHAN/ESPGHAN guidelines recommendation for management. With well-defined parameters, this commentary discusses the paths followed by the literature to implement different therapeutic modalities over time. The text will prioritize information based on systematic reviews, meta-analyses, or reviews. Recently, an Editorial exploring gastrointestinal diseases across the Lifespan linked constipation as a “vexing issue that, unfortunately, has the potential to impair Health-Related Quality of Life (HRQOL).” Indeed, The Rome Foundation recommended that HRQOL scores may assist in diagnosis, management, prognosis, and therapeutic decisions. Therefore, it can be helpful for clinicians, psychologists, and researchers and could be used to support health services that want to implement an HRQOL program. The final idea is to propose HRQOL as a secondary outcome for Pediatric FC monitoring this disorder.
功能性便秘（Functional constipation，FC）的全球总发病率为 9.5%，根据《罗马标准》（Rome IV Criteria）有明确的定义，NAPGHAN/ESPGHAN 指南也推荐了治疗方法。有了明确定义的参数，本评论将讨论随着时间的推移，不同治疗方法的文献路径。文中将根据系统综述、荟萃分析或评论对信息进行优先排序。最近，一篇探讨全生命周期胃肠道疾病的社论将便秘列为 "令人烦恼的问题，不幸的是，它有可能损害与健康相关的生活质量（HRQOL）"。事实上，罗马基金会建议，HRQOL 评分可以帮助诊断、管理、预后和治疗决策。因此，它可以帮助临床医生、心理学家和研究人员，并可用于支持希望实施 HRQOL 计划的医疗服务机构。最后一个想法是建议将 HRQOL 作为儿科 FC 监测这种疾病的次要结果。
{"title":"Pediatric Functional Constipation in Clinical Practice: The Continuous Search for the Light at the End of the Tunnel","authors":"N. Machado, Juliana Tedesco Dias, Gabriela Nascimento Hercos, Thabata Koester Weber, Mary de Assis Carvalho","doi":"10.33696/gastroenterology.4.047","DOIUrl":"https://doi.org/10.33696/gastroenterology.4.047","url":null,"abstract":"Functional constipation (FC) has a pooled world prevalence of 9.5%, a clear definition by Rome IV Criteria, and the NAPGHAN/ESPGHAN guidelines recommendation for management. With well-defined parameters, this commentary discusses the paths followed by the literature to implement different therapeutic modalities over time. The text will prioritize information based on systematic reviews, meta-analyses, or reviews. Recently, an Editorial exploring gastrointestinal diseases across the Lifespan linked constipation as a “vexing issue that, unfortunately, has the potential to impair Health-Related Quality of Life (HRQOL).” Indeed, The Rome Foundation recommended that HRQOL scores may assist in diagnosis, management, prognosis, and therapeutic decisions. Therefore, it can be helpful for clinicians, psychologists, and researchers and could be used to support health services that want to implement an HRQOL program. The final idea is to propose HRQOL as a secondary outcome for Pediatric FC monitoring this disorder.","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"57 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138945833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.33696/gastroenterology.4.046
Luis Fonte Galindo, Yamilé Aleaga Santiesteban, María Ginori Gilke, Yosiel Molina, Yisel Hernández Barrios
Numerous studies have found an association between infection by some species of intestinal parasites and the development of urticarial lesions. In this document we have commented on the published findings that show the association between infection by Blastocystis spp. and urticaria, and on the theorizations in relation to the mechanisms that would explain it. Due to sharing risk factors and transmission ways, there is a marked geographic coincidence among intestinal parasitic infections. In fact, polyparasitism is a common phenomenon in low- and middle-income countries in Sub-Saharan Africa, Asia, Latin America, and the Caribbean where infections by protozoa and intestinal helminths are endemic. This argument, among others, suggest that the epidemiological and healthcare approach to urticaria associated with infection by Blastocystis spp. should be done from a syndemic approach that takes into account the ways in which social environments contribute to intestinal parasite infections clustering, the pathways through which those infections could interact biologically in each individual influencing the development and evolution of urticarial lesions, and the ways in which those interactions complicate diagnosis and treatment.
{"title":"Blastocystosis and Urticaria: An Overview from a Syndemic Perspective","authors":"Luis Fonte Galindo, Yamilé Aleaga Santiesteban, María Ginori Gilke, Yosiel Molina, Yisel Hernández Barrios","doi":"10.33696/gastroenterology.4.046","DOIUrl":"https://doi.org/10.33696/gastroenterology.4.046","url":null,"abstract":"Numerous studies have found an association between infection by some species of intestinal parasites and the development of urticarial lesions. In this document we have commented on the published findings that show the association between infection by Blastocystis spp. and urticaria, and on the theorizations in relation to the mechanisms that would explain it.\u0000\u0000Due to sharing risk factors and transmission ways, there is a marked geographic coincidence among intestinal parasitic infections. In fact, polyparasitism is a common phenomenon in low- and middle-income countries in Sub-Saharan Africa, Asia, Latin America, and the Caribbean where infections by protozoa and intestinal helminths are endemic. This argument, among others, suggest that the epidemiological and healthcare approach to urticaria associated with infection by Blastocystis spp. should be done from a syndemic approach that takes into account the ways in which social environments contribute to intestinal parasite infections clustering, the pathways through which those infections could interact biologically in each individual influencing the development and evolution of urticarial lesions, and the ways in which those interactions complicate diagnosis and treatment.","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"33 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138945850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-02DOI: 10.33696/gastroenterology.4.045
Roberto Sam, Sel Neal
The global incidence of metabolic disorders is on the rise, posing a significant challenge to public health. With remarkable advancements in diagnostic tools and clinical procedures, our understanding of the etiology and underlying pathophysiology of these disorders has expanded considerably. Furthermore, the utilization of in vitro and in vivo experimental models, preceding clinical investigations, has catalyzed numerous breakthroughs in biomedicine, particularly in the identification and development of potential drug candidates for the management of metabolic disorders. Natural compounds isolated from various sources have garnered extensive attention as prospective drug candidates for the treatment of conditions such as diabetes, obesity, heart-related diseases, and cancer. This interest is partly attributed to their inherent antioxidant and anti-inflammatory properties. Concurrently, intensive research efforts have been directed towards enhancing the bioactivity and bioavailability of these compounds through selected drug delivery strategies. In this article, we provide valuable insights into recent advancements that shed light on the role of inflammatory-mediated responses in the initiation of metabolic disorders, with a specific focus on conditions like diabetes mellitus, obesity, heart-related diseases, cancer, and related drug delivery systems. Additionally, we explore the promising potential of natural products in managing these metabolic disorders. Furthermore, we present lists of potential biological targets suitable for high throughput screening in the drug discovery and development process. Finally, we delve into the findings gleaned from preclinical and clinical studies, setting the stage for the identification of suitable approaches in the realm of phytochemical drug delivery systems that hold promise for the treatment of metabolic disorders.
{"title":"Advancements in Drug Delivery Systems for Natural Compounds Targeting Metabolic Disorders Associated with Inflammation","authors":"Roberto Sam, Sel Neal","doi":"10.33696/gastroenterology.4.045","DOIUrl":"https://doi.org/10.33696/gastroenterology.4.045","url":null,"abstract":"The global incidence of metabolic disorders is on the rise, posing a significant challenge to public health. With remarkable advancements in diagnostic tools and clinical procedures, our understanding of the etiology and underlying pathophysiology of these disorders has expanded considerably. Furthermore, the utilization of in vitro and in vivo experimental models, preceding clinical investigations, has catalyzed numerous breakthroughs in biomedicine, particularly in the identification and development of potential drug candidates for the management of metabolic disorders. Natural compounds isolated from various sources have garnered extensive attention as prospective drug candidates for the treatment of conditions such as diabetes, obesity, heart-related diseases, and cancer. This interest is partly attributed to their inherent antioxidant and anti-inflammatory properties. Concurrently, intensive research efforts have been directed towards enhancing the bioactivity and bioavailability of these compounds through selected drug delivery strategies. In this article, we provide valuable insights into recent advancements that shed light on the role of inflammatory-mediated responses in the initiation of metabolic disorders, with a specific focus on conditions like diabetes mellitus, obesity, heart-related diseases, cancer, and related drug delivery systems. Additionally, we explore the promising potential of natural products in managing these metabolic disorders. Furthermore, we present lists of potential biological targets suitable for high throughput screening in the drug discovery and development process. Finally, we delve into the findings gleaned from preclinical and clinical studies, setting the stage for the identification of suitable approaches in the realm of phytochemical drug delivery systems that hold promise for the treatment of metabolic disorders.","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138607119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.33696/gastroenterology.4.042
O. Hernández, Zoilo K Suarez, Talwinder K Nagi, M. A. Haider, Charles Vallejo, Fatima Ahson
Non-alcoholic fatty liver disease (NAFLD) is a major cause of cirrhosis and liver failure globally. Despite its broad impact, screening recommendations for NAFLD remain varied based between gastrointestinal societies. Point of care ultrasound (POCUS) has emerged as a new form of screening and diagnosing intrabdominal pathologies including NAFLD. We aimed to estimate the effectiveness of POCUS in screening for NAFLD compared to formal ultrasound when screening by general practitioners trained in ultrasonography. Data was collected from Cochrane, PubMed, Embase, and Google Scholar using search terms related to POCUS and NAFLD screening. Observational cross-sectional studies were included in our analysis. Reviewers evaluated articles for eligibility and extracted data for analysis. The risk of bias was assessed by reviewers using a validated risk of bias assessment tool. Discrepancies between authors were resolved by a third reviewer or by consensus. Our review found 3 studies (n = 428) that met our eligibility criteria. Our review found that POCUS was 93% sensitive and 98% specific when screening for NAFLD compared to formal ultrasound. We concluded that POCUS is an acceptable method of screening for NAFLD when used by general practitioners trained in ultrasonography. Further, more robust, studies are required to validate the findings of our review and elucidate further horizons on this emerging screening method.
{"title":"Exploring the Use of Point of Care Ultrasound in Screening for Non-Alcoholic Fatty Liver Disease: A Systematic Literature Review and Meta-Analysis","authors":"O. Hernández, Zoilo K Suarez, Talwinder K Nagi, M. A. Haider, Charles Vallejo, Fatima Ahson","doi":"10.33696/gastroenterology.4.042","DOIUrl":"https://doi.org/10.33696/gastroenterology.4.042","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is a major cause of cirrhosis and liver failure globally. Despite its broad impact, screening recommendations for NAFLD remain varied based between gastrointestinal societies. Point of care ultrasound (POCUS) has emerged as a new form of screening and diagnosing intrabdominal pathologies including NAFLD. We aimed to estimate the effectiveness of POCUS in screening for NAFLD compared to formal ultrasound when screening by general practitioners trained in ultrasonography. Data was collected from Cochrane, PubMed, Embase, and Google Scholar using search terms related to POCUS and NAFLD screening. Observational cross-sectional studies were included in our analysis. Reviewers evaluated articles for eligibility and extracted data for analysis. The risk of bias was assessed by reviewers using a validated risk of bias assessment tool. Discrepancies between authors were resolved by a third reviewer or by consensus. Our review found 3 studies (n = 428) that met our eligibility criteria. Our review found that POCUS was 93% sensitive and 98% specific when screening for NAFLD compared to formal ultrasound. We concluded that POCUS is an acceptable method of screening for NAFLD when used by general practitioners trained in ultrasonography. Further, more robust, studies are required to validate the findings of our review and elucidate further horizons on this emerging screening method.","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89681870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-11DOI: 10.33696/gastroenterology.4.041
A. AlShahrabally, D. Coghlan, S. Quinn
We described a 15-year-old- a boy who presented with neurofibromatosis type 1 and Crohn’s disease. Neurofibromatosis 1 (NF1) is the most common form of NF, affecting 1 in 3000 individuals. Crohn’s disease is one of the inflammatory bowel diseases. Its incidence is significantly rising in Ireland. Concomitant association of NF1 and Crohn’s disease is a rare finding. This is the first case reported in the paediatric population.
{"title":"Neurofibromatosis Type 1 and Crohn’s Disease Association: Case Report","authors":"A. AlShahrabally, D. Coghlan, S. Quinn","doi":"10.33696/gastroenterology.4.041","DOIUrl":"https://doi.org/10.33696/gastroenterology.4.041","url":null,"abstract":"We described a 15-year-old- a boy who presented with neurofibromatosis type 1 and Crohn’s disease. Neurofibromatosis 1 (NF1) is the most common form of NF, affecting 1 in 3000 individuals. Crohn’s disease is one of the inflammatory bowel diseases. Its incidence is significantly rising in Ireland. Concomitant association of NF1 and Crohn’s disease is a rare finding. This is the first case reported in the paediatric population.","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"401 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76529771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-04DOI: 10.33696/gastroenterology.3.039
Vishnu P. Tripathi, H. Ahmed, Naidia Renulos, M. K. Aneebuddin
Vishnu P. Tripathi1, Haamza Ahmed2, Naidia Renulos3, M K Aneebuddin4 1Department of Biotechnology, V.B.S. Purvanchal University, Jaunpur, India 2Department of Biomedical Engineering, University of Memphis, USA 3Department of infectious biology, University of Verona, Italy 4Department of Pharmaceutics, Shadan College of Pharmacy, Telangana State, India *Correspondence should be addressed to Vishnu P. Tripathi, tripatipvishnu@gmail.com
Vishnu P. Tripathi1, Haamza Ahmed2, Naidia renulo3, M K Aneebuddin4 1印度Jaunpur Purvanchal大学生物技术系2美国孟菲斯大学生物医学工程系3意大利维罗纳大学感染生物系4印度特伦加纳邦沙丹药学院药剂学系*信件请寄给Vishnu P. Tripathi, tripatipvishnu@gmail.com
{"title":"Elucidating the Role of Chemokines in Infectious Diseases and Gastric Cancer","authors":"Vishnu P. Tripathi, H. Ahmed, Naidia Renulos, M. K. Aneebuddin","doi":"10.33696/gastroenterology.3.039","DOIUrl":"https://doi.org/10.33696/gastroenterology.3.039","url":null,"abstract":"Vishnu P. Tripathi1, Haamza Ahmed2, Naidia Renulos3, M K Aneebuddin4 1Department of Biotechnology, V.B.S. Purvanchal University, Jaunpur, India 2Department of Biomedical Engineering, University of Memphis, USA 3Department of infectious biology, University of Verona, Italy 4Department of Pharmaceutics, Shadan College of Pharmacy, Telangana State, India *Correspondence should be addressed to Vishnu P. Tripathi, tripatipvishnu@gmail.com","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86028359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-04DOI: 10.33696/gastroenterology.3.037
F. Silano, R. Amaral, V. Neves, Rodolfo Santana, Paulo Cézar, Galvão do Amaral
Although gastrointestinal stromal tumors, GISTs, are the most common neoplasms arising from the gastrointestinal mesenchyme, they represent less than 1% of all digestive tumors [1]. Its incidence has increased in recent years, probably due to improved diagnostic methods [2]. It is currently known that GIST is the most common sarcoma [3]. It originates from interstitial cells of Cajal and depends on the transcription factor ETV-1. These are neoplasms associated with molecular alterations and some mutations: In more than 75% of cases there is the KIT mutation (CD 117) [3], 10% have mutation in platelet-derived growth factor receptor alpha (PDGFRA) and wild-type GISTs have a mutation in the SDH pathway [3]. There does not seem to be a predilection between the sexes. They affect a wide age range, but in around 75% of cases, it is more common over 50 years of age [4]. Any organ of the digestive tract can be affected by GIST, however more than 50% of cases are seen in the stomach, 25% in the small intestine and a minority in the colon, rectum, retroperitoneum, omentum, among others [5-9]. Its size can vary from millimetric lesions to the so-called giant GISTs, a definition in the literature for those with more than 10 cm in diameter [10].
{"title":"Gastric GIST with 13 kg in Asymptomatic Patient: A Rare Case of Giant GIST and Literature Review","authors":"F. Silano, R. Amaral, V. Neves, Rodolfo Santana, Paulo Cézar, Galvão do Amaral","doi":"10.33696/gastroenterology.3.037","DOIUrl":"https://doi.org/10.33696/gastroenterology.3.037","url":null,"abstract":"Although gastrointestinal stromal tumors, GISTs, are the most common neoplasms arising from the gastrointestinal mesenchyme, they represent less than 1% of all digestive tumors [1]. Its incidence has increased in recent years, probably due to improved diagnostic methods [2]. It is currently known that GIST is the most common sarcoma [3]. It originates from interstitial cells of Cajal and depends on the transcription factor ETV-1. These are neoplasms associated with molecular alterations and some mutations: In more than 75% of cases there is the KIT mutation (CD 117) [3], 10% have mutation in platelet-derived growth factor receptor alpha (PDGFRA) and wild-type GISTs have a mutation in the SDH pathway [3]. There does not seem to be a predilection between the sexes. They affect a wide age range, but in around 75% of cases, it is more common over 50 years of age [4]. Any organ of the digestive tract can be affected by GIST, however more than 50% of cases are seen in the stomach, 25% in the small intestine and a minority in the colon, rectum, retroperitoneum, omentum, among others [5-9]. Its size can vary from millimetric lesions to the so-called giant GISTs, a definition in the literature for those with more than 10 cm in diameter [10].","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78385297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-04DOI: 10.33696/gastroenterology.3.036
V. Faerber, K. Kuhn, E. Svehlikova, A. Kuchinka-Koch, T. Pieber
Valentin Faerber1*, Katharina Stefanie Kuhn2, Eva Svehlikova3, Angelika Kuchinka-Koch4, Thomas R Pieber3 1Department of Medical, Clinical & Regulatory Affairs, Business Unit Parenteral Nutrition, Keto-Analogues and Standard I.V. Fluids, Fresenius Kabi Deutschland GmbH, Bad Homburg, Germany 2Medical Writing, Stuttgart, Germany 3Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz 8036, Austria 4Market Unit Lactulose, Fresenius Kabi Austria GmbH, Linz, Austria *Correspondence should be addressed to Valentin Faerber; Valentin.faerber@fresenius-kabi.com
Valentin Faerber1*， Katharina Stefanie Kuhn2, Eva svehlikov3, Angelika Kuchinka-Koch4, Thomas R Pieber3 1费森尤斯卡比德国有限公司医学、临床和法规部，肠外营养、酮类类似物和标准静脉输液业务部2医学写作，斯图加特，德国3格拉茨医科大学内科内分泌和糖尿病学系，格拉茨8036，奥地利4市场单位乳糖，费森尤斯卡比奥地利有限公司，奥地利林茨*信件应寄给Valentin Faerber;Valentin.faerber@fresenius-kabi.com
{"title":"Oral Lactulose – A Safe and Effective Strategy for the Management of Constipation in Individuals with Impaired Glucose Tolerance and Diabetes","authors":"V. Faerber, K. Kuhn, E. Svehlikova, A. Kuchinka-Koch, T. Pieber","doi":"10.33696/gastroenterology.3.036","DOIUrl":"https://doi.org/10.33696/gastroenterology.3.036","url":null,"abstract":"Valentin Faerber1*, Katharina Stefanie Kuhn2, Eva Svehlikova3, Angelika Kuchinka-Koch4, Thomas R Pieber3 1Department of Medical, Clinical & Regulatory Affairs, Business Unit Parenteral Nutrition, Keto-Analogues and Standard I.V. Fluids, Fresenius Kabi Deutschland GmbH, Bad Homburg, Germany 2Medical Writing, Stuttgart, Germany 3Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz 8036, Austria 4Market Unit Lactulose, Fresenius Kabi Austria GmbH, Linz, Austria *Correspondence should be addressed to Valentin Faerber; Valentin.faerber@fresenius-kabi.com","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73968496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-04DOI: 10.33696/gastroenterology.3.040
Shiv K. Desai, C. Schammel, D. Schammel, A. Devane, D. Steven, Trocha
A Case Report and Diagnostic Algorithm for Intraductal Abstract Intraductal lesions of the pancreas are an increasingly recognized, radiologically detectable group of entities that require a systematic diagnostic approach to best define management given their variable prognoses. A case of isolated intraductal tubular adenoma (ITA) is reported with a comprehensive literature review; comparison of ITAs with intraductal papillary mucinous neoplasms (IPMNs) and intraductal tubular carcinomas (ITCs) is made with assessment of their distinctive imaging and histological findings and discussion of the evolution of these lesions’ classifications with regards to the established literature. We designed and propose an algorithm for the evaluation of these intraductal lesions to create a systematic approach for the diagnosis and management of such lesions. and histologic characteristics mirrored the aforementioned findings from the MPD; no increased mitotic rate, cytological atypia, or necrosis were identified. IHC indeterminant
{"title":"Intraductal Tubular Adenoma: A Case Report and Diagnostic Algorithm for Intraductal Pancreatic Lesions","authors":"Shiv K. Desai, C. Schammel, D. Schammel, A. Devane, D. Steven, Trocha","doi":"10.33696/gastroenterology.3.040","DOIUrl":"https://doi.org/10.33696/gastroenterology.3.040","url":null,"abstract":"A Case Report and Diagnostic Algorithm for Intraductal Abstract Intraductal lesions of the pancreas are an increasingly recognized, radiologically detectable group of entities that require a systematic diagnostic approach to best define management given their variable prognoses. A case of isolated intraductal tubular adenoma (ITA) is reported with a comprehensive literature review; comparison of ITAs with intraductal papillary mucinous neoplasms (IPMNs) and intraductal tubular carcinomas (ITCs) is made with assessment of their distinctive imaging and histological findings and discussion of the evolution of these lesions’ classifications with regards to the established literature. We designed and propose an algorithm for the evaluation of these intraductal lesions to create a systematic approach for the diagnosis and management of such lesions. and histologic characteristics mirrored the aforementioned findings from the MPD; no increased mitotic rate, cytological atypia, or necrosis were identified. IHC indeterminant","PeriodicalId":8277,"journal":{"name":"Archives of Gastroenterology Research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82659274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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