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Antiurolithiatic Activity of the Leaf Extracts of Maerua Angolensis 安哥拉毛蕊叶提取物抗尿石活性研究
Pub Date : 2019-10-23 DOI: 10.33552/appr.2019.01.000535
A. Kaushik
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引用次数: 0
Antiurolithiatic Activity of the Leaf Extracts of Maerua Angolensis 安哥拉毛蕊叶提取物抗尿石活性研究
Pub Date : 2019-10-23 DOI: 10.33552/appr.2019.02.000535
A. Kaushik
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引用次数: 2
The Collagen Challenge: Preventing Myocardial Fibrosis Is the Hype Reflective of the Potential? 胶原蛋白的挑战:预防心肌纤维化的宣传是否反映了其潜力?
Pub Date : 2019-10-01 DOI: 10.33552/appr.2019.01.000534
J. Rozich
Mounting evidence has suggested that the cardiac extracellular matrix (ECM) has a nuanced but determinative role in myocardial remodeling in response to pathological insult and subsequent recovery [1-3]. These alterations in the structure and actual composition of ECM may actually reflect many of the welldescribed phenotypic cardiac properties typical of common diseases states including diabetes, hypertension, obesity and ischemia. Current thought is that dysregulatory influences result in a maladaptive remodeling process that begins an inevitable progression to irreversible and often untimely cardiac failure [1,2]. This potentially injurious perturbation in the dysfunctional ECM response is complex involving profibrotic collagen synthesis and post-translational modification including increased crosslinking and reduced degradation [1,4]. The result is a stiffening noncompliant and impaired myocardium that underpins observed clinical changes causing the heart failure syndrome. Sampling changing serum levels of distinct proteins or molecular fragments are now being used to assess collagen turnover. This includes using the N-terminal propeptide of procollagen type III and C-terminal propeptide of procollagen type I considered directly correlative to histologically proven fibrosis [1,5]. Other biomarkers have been proposed to be associated with pathology involving collagen metabolism, (tissue inhibitor of metalloproteinases-1 (TIMP-1), matrix metalloproteinase [MMP]-2, MMP-9, galectin-3 [Gal-3], etc) but are not yet validated as directly representative of histologically confirmed fibrosis [1,6].
越来越多的证据表明,心肌细胞外基质(ECM)在病理损伤和随后恢复的心肌重构中具有微妙但决定性的作用[1-3]。ECM结构和实际组成的这些改变实际上可能反映了许多常见疾病(包括糖尿病、高血压、肥胖和缺血)典型的表型心脏特性。目前的想法是,失调的影响导致适应性不良的重塑过程,开始不可避免地发展为不可逆的,往往是过早的心力衰竭[1,2]。在功能失调的ECM反应中,这种潜在的有害扰动是复杂的,涉及原纤维化胶原合成和翻译后修饰,包括交联增加和降解减少[1,4]。其结果是硬化不顺应和受损的心肌,支持观察到的临床变化,导致心力衰竭综合征。不同蛋白质或分子片段的血清水平变化取样现在被用来评估胶原蛋白的周转。这包括使用被认为与组织学证实的纤维化直接相关的III型前胶原的n端前肽和I型前胶原的c端前肽[1,5]。其他生物标志物已被提出与胶原代谢相关的病理(组织金属蛋白酶抑制剂-1 (TIMP-1)、基质金属蛋白酶[MMP]-2、MMP-9、半乳糖凝集素-3 [Gal-3]等),但尚未被证实为组织学证实的纤维化的直接代表[1,6]。
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引用次数: 0
Effects of Antipsychotic Drugs on Neuroactive Steroids Brain and Plasma Levels in Humans and Animals: A Systematic Review of the Literature 抗精神病药物对人类和动物神经活性类固醇脑和血浆水平的影响:文献系统综述
Pub Date : 2019-09-26 DOI: 10.33552/appr.2019.01.000533
E. Nunes
Schizophrenia follows as one of the most challenge mental disorders, despite the highly available pharmacological treatment options, currently represented mainly by antipsychotic medications [1,2]. Most of these antipsychotic medications have in common some level of antagonism of dopamine type 2 receptors (D2) and also blockade of 5HT2A serotonin receptors is present in some of these compounds [3,4]. Even with the different types of currently available antipsychotics, all of them as stated earlier, have in common some blockade of D2 receptors. This pharmacodynamics effect is in accordance to the main theory that tries to explain the physiopathology of schizophrenia, the dopaminergic theory (CARLSSON AND LINDQVIST, 1963). Albeit reasonable improvement can be achieved with the use of antipsychotic to treat schizophrenia symptoms, especially when we consider the positive symptoms (hallucinations and delusions), almost one third of all patients is completely refractory to pharmacological approaches [1,5]. Therefore, the need for new drugs that target other neurotransmission systems other than the dopamine transmission is urgent [6] and the neuroactive steroids, like pregnenolone glutamate has attracted great attention ISSN: 2641-2020 DOI: 10.33552/APPR.2019.02.000533
精神分裂症是最具挑战性的精神障碍之一,尽管有高度可用的药物治疗选择,目前主要是抗精神病药物[1,2]。大多数抗精神病药物都有一定程度的多巴胺2型受体(D2)拮抗作用,其中一些化合物也存在5HT2A血清素受体的阻断作用[3,4]。即使是目前可用的不同类型的抗精神病药物,如前所述,它们都有一些共同的D2受体阻断。这种药效学效应符合试图解释精神分裂症生理病理的主要理论,即多巴胺能理论(CARLSSON AND LINDQVIST, 1963)。尽管使用抗精神病药物治疗精神分裂症症状可以实现合理的改善,特别是当我们考虑到阳性症状(幻觉和妄想)时,几乎三分之一的患者对药物治疗完全难治[1,5]。因此,迫切需要针对多巴胺传递以外的其他神经传递系统的新药[6],孕烯醇酮谷氨酸等神经活性类固醇引起了人们的极大关注。ISSN: 2641-2020 DOI: 10.33552/APPR.2019.02.000533
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引用次数: 0
Relation of Pulse Rate with Flu Medication Treatment 脉搏率与流感药物治疗的关系
Pub Date : 2019-09-25 DOI: 10.33552/appr.2019.01.000532
Bushra Khalid
Influenza is caused by Influenza virus which has many types A, B, C and D. Each type is divided into subtypes like Influenza A (H1N1 and H3N2) are most common. Its symptoms have resemblance with cold but if it is not treated properly then many nearby healthy individual also affected by flu. Vaccination is best way for prevention but some people prefers medication while other prefer home remedies for flu treatment. Heart is muscular organ which is responsible for blood pumping moreover a healthy pulse rate declare that heart is at right state. Abnormal pulse rate is associated with many other illnesses. To measure the pulse rate, hold the hand as its palm side up and by placing the two fingers on wrist feel pulse rate and count it for one minute by using stopwatch. Finally, here is significant relation is observed for flu treatment with pulse rate.
流感是由流感病毒引起的,流感病毒有A、B、C和d多种类型,每种类型又分为亚型,其中甲型流感(H1N1和H3N2)最常见。它的症状与感冒相似,但如果治疗不当,许多附近的健康人也会感染流感。接种疫苗是预防流感的最好方法,但有些人更喜欢药物治疗,而另一些人则喜欢在家治疗流感。心脏是负责血液输送的肌肉器官,而且健康的脉搏率表明心脏处于正常状态。脉搏异常与许多其他疾病有关。测量脉搏率时,将手掌朝上,将两根手指放在手腕上,用秒表测量脉搏率,计数一分钟。最后,观察到流感治疗与脉搏率有显著关系。
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引用次数: 0
Mikania Cordata (Burm.F.) B.L. Rob. – A Bangladesh Folk Medicinal Plant for Gastric Disorders 薇甘菊(缅甸)文学士抢劫。-一种孟加拉民间治疗胃病的药用植物
Pub Date : 2019-09-18 DOI: 10.33552/appr.2019.02.000531
M. Rahmatullah
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引用次数: 1
Mikania Cordata (Burm.F.) B.L. Rob. – A Bangladesh Folk Medicinal Plant for Gastric Disorders 薇甘菊(缅甸)文学士抢劫。-一种孟加拉民间治疗胃病的药用植物
Pub Date : 2019-09-18 DOI: 10.33552/appr.2019.01.000531
Mohammed Rahmatullah Dean
Plants produce a bewildering variety of phytochemicals, otherwise known as secondary metabolites. Secondary metabolites are compounds, which are not necessary for a plant cell to live but are necessary for a plant to survive biotic or abiotic stresses [1]. Secondary metabolites can produce pharmacological responses when introduced into humans, which in turn can be toxic or serve therapeutic purposes. A number of such secondary metabolites have been isolated and have found uses in medicine like aconitine, L-hyoscyamine, camptothecin, tetrahydrocannabinol, and tubocurarine, to name only a few [2]. Although the existence of secondary metabolites were possibly not known or understood by ancient hominids, plants have always played a role in the treatment of diseases from the beginning of humankind. Medicinal plant material has been found in a 60, 000 year old Neanderthal grave in Iraq [3]. Early Asian and Egyptian texts (since the discovery of writing and writing materials) mention medicinal plants and their uses [4]. Use of plants as medicines since time immemorial gradually led to the establishment of distinct forms of traditional medicinal practices like the Ayurveda in India, Unani in Greece, Kampo in Japan, and other systems throughout the world [5]. Besides these ‘ritualized’ forms of traditional medicinal systems, there also exists folk medicine (FM), tribal medicine (TM, same as FM but practiced by tribal people instead of the mainstream population), and home remedies. Allopathic medicine has borrowed heavily from traditional medicinal practices and more than a hundred allopathic drugs are plant-derived [6]. It has been said that approximately 7080% of primary health care throughout the world is based on plant materials [7].
植物产生令人眼花缭乱的各种植物化学物质,也被称为次生代谢物。次生代谢物是一种化合物,它不是植物细胞生存所必需的,但却是植物在生物或非生物胁迫下生存所必需的[1]。次生代谢物进入人体后可产生药理学反应,这反过来可能是有毒的或用于治疗目的。许多这样的次生代谢物已经被分离出来,并在诸如乌头碱、l -山莨菪碱、喜树碱、四氢大麻酚和管curarine等药物中得到了应用[2]。虽然次生代谢物的存在可能不为古人类所知或所理解,但从人类开始,植物就一直在疾病的治疗中发挥着作用。在伊拉克的一个6万年前的尼安德特人坟墓中发现了药用植物[3]。早期的亚洲和埃及文献(自文字和书写材料的发现以来)提到了药用植物及其用途[4]。自古以来,植物作为药物的使用逐渐导致了不同形式的传统医学实践的建立,如印度的阿育吠陀,希腊的乌纳尼,日本的康布,以及世界各地的其他系统[5]。除了这些“仪式化”的传统医疗体系之外,还有民间医学(FM)、部落医学(TM,与FM相同,但由部落人而不是主流人群实践)和家庭疗法。对抗疗法大量借鉴了传统医学实践,有100多种对抗疗法药物是从植物中提取的[6]。据说,全世界大约7080%的初级卫生保健是基于植物材料[7]。
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引用次数: 0
Expanding the Kidney Donor Pool through Use of Hepatitis C-Infected Donors: is it Time to Dive in? 通过使用丙型肝炎感染者的供体来扩大肾脏供体池:是时候投入了吗?
Pub Date : 2019-09-13 DOI: 10.33552/appr.2019.01.000530
Gretchen M. Kipp, L. Biondi, D. Kannabhiran
The survival benefit of kidney transplantation for patients with end-stage renal disease (ESRD) is well established. However, the demand for kidney donor organs greatly exceeds the current supply. The use of hepatitis C infected donors could increase the number of kidneys available for transplantation. The use of highly effective second-generation direct acting antivirals (DAAs) has been recently studied for the prevention of chronic hepatitis C virus (HCV) infection in kidney transplant recipients who are HCV negative and receive HCV infected kidney allografts. Small, open-label trials have demonstrated the feasibility of using DAAs as either preand post-exposure prophylaxis or as treatment after detection of HCV transmission. Short term outcomes illustrate 100% prevention of chronic HCV infection with renal function and allograft survival that are comparable to recipients of non-HCV infected kidney donors. Long-term allograft and patient outcomes are required to determine whether the use of HCV infected organs should be considered for all patients with ESRD waiting for kidney transplant. The survival benefit of kidney transplantation for patients with end-stage renal disease (ESRD) is well established [1,2]. However, the demand for kidney donor organs greatly exceeds the current supply which encourages organ procurement organizations and transplant centers to look for innovative strategies to increase the donor pool. Recently, the opioid crisis has increased the number of overdose deaths exponentially [3]. Additionally, the number of hepatitis C virus (HCV) seropositive donors increased from 452 organs per year to 1506 per year between the years of 2000 and 2016 but only 57% of the HCV seropositive kidneys were transplanted in 2016 [4]. The use of hepatitis C infected donors could increase the number of kidneys available for transplantation but this strategy has historically been avoided because of risk of HCV transmission as well as inadequate treatment response and risk of rejection with interferon-based regimens. The advent of highly effective secondgeneration direct acting antivirals (DAAs) has increased viral cure of patients with chronic HCV infection to more than 96% [5-7]. Ongoing research is investigating whether DAAs can be prescribed post-transplant to HCV negative recipients receiving HCV infected donors to increase the donor pool.
肾移植对终末期肾病(ESRD)患者的生存益处是公认的。然而,对肾脏捐赠器官的需求大大超过了目前的供应。使用感染丙型肝炎的供体可以增加可用于移植的肾脏数量。最近研究了使用高效的第二代直接作用抗病毒药物(DAAs)预防慢性丙型肝炎病毒(HCV)感染在HCV阴性肾移植受者和接受HCV感染的同种异体肾移植受者中。小型开放标签试验已经证明,使用DAAs作为暴露前和暴露后预防或检测到HCV传播后的治疗是可行的。短期结果表明,慢性丙型肝炎病毒感染的100%预防与肾功能和同种异体移植存活率相当,与非丙型肝炎病毒感染的肾脏供体受体相当。对于所有等待肾移植的ESRD患者,是否应该考虑使用HCV感染的器官,需要长期的同种异体移植和患者预后。终末期肾病(ESRD)患者肾移植的生存益处已得到充分证实[1,2]。然而,对肾脏供体器官的需求大大超过了目前的供应,这鼓励器官采购组织和移植中心寻找创新策略来增加供体库。最近,阿片类药物危机使过量死亡人数呈指数增长[3]。此外,从2000年到2016年,丙型肝炎病毒(HCV)血清阳性供体的数量从每年452个增加到每年1506个,但2016年只有57%的HCV血清阳性肾脏被移植[4]。使用丙型肝炎感染的供者可以增加可用于移植的肾脏数量,但由于丙型肝炎病毒传播的风险以及治疗反应不足和干扰素方案的排斥风险,这种策略历来被避免。高效的第二代直接作用抗病毒药物(DAAs)的出现使慢性HCV感染患者的病毒治愈率提高到96%以上[5-7]。正在进行的研究正在调查是否可以在移植后给接受HCV感染供者的HCV阴性受者开DAAs以增加供者池。
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引用次数: 0
Do Folk Medicinal Practices of Bangladesh Have any Scientific Value? an Appraisal of Phytotherapeutic Practices of a Rural Folk Medicinal Practitioner 孟加拉国民间医学实践有科学价值吗?某农村民间医师植物治疗实践评价
Pub Date : 2019-09-09 DOI: 10.33552/appr.2019.01.000529
Mohammed Rahmatullah Dean
Folk medicine (FM) is practiced by part-time or full-time folk medicinal practitioners (FMPs) in Bangladesh, utilizing for the most part plant-based remedies as their modus operandi for treatment of practically all ailments suffered by the Bangladesh people. FM is not unique to Bangladesh; it is present in practically every country of the world under different names or guises like home remedies, herbal remedies, etc. With time, FM can even take on a more formal form in which cases they are known as Ayurveda and Siddha (in India), Unani (in Greece) or Kampo (in Japan). People of Thailand are said to use herbal remedies since the Sukothai period (12381377) [1]. However, the use of plants as medicines dates back to much earlier times. Radiocarbon dating shows that plants were cultivated in ancient Babylon (present Iraq) more than 60,000 years ago [2]. It is possibly safe to say that human beings have suffered from ailments since their very advent and have tried to cure such ailments possibly from the earliest human ancestors about 6-7 million years ago – the Australopithecines [3]. It is to be taken into account that the great apes and other animal species instinctively partake of some plants for medicinal purposes [4], and the earliest hominids could have easily caught onto this ‘cure’ system.
民间医学(FM)是由孟加拉国的兼职或全职民间医生(fmp)实践的,他们主要利用植物疗法作为治疗孟加拉国人民几乎所有疾病的方法。FM并非孟加拉国独有;它以不同的名称或伪装存在于世界上的每个国家,如家庭疗法、草药疗法等。随着时间的推移,FM甚至可以采取更正式的形式,在这种情况下,它们被称为阿育吠陀和悉达陀(在印度),Unani(在希腊)或Kampo(在日本)。据说泰国人从素可泰时期(12381377)就开始使用草药[1]。然而,植物作为药物的使用可以追溯到更早的时代。放射性碳定年法表明,植物在6万多年前就在古巴比伦(现在的伊拉克)种植了[2]。可以肯定地说,人类自出现以来就饱受病痛之苦,并且可能从大约600万至700万年前最早的人类祖先——南方古猿[3]开始尝试治疗这些病痛。要考虑到,类人猿和其他动物出于药用目的本能地吃一些植物[4],而最早的原始人很容易就掌握了这种“治疗”系统。
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引用次数: 0
Do Folk Medicinal Practices of Bangladesh Have any Scientific Value? an Appraisal of Phytotherapeutic Practices of a Rural Folk Medicinal Practitioner 孟加拉国民间医学实践有科学价值吗?某农村民间医师植物治疗实践评价
Pub Date : 2019-09-09 DOI: 10.33552/appr.2019.02.000529
M. Rahmatullah
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引用次数: 1
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Archives of Pharmacy & Pharmacology Research
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