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Association of Subclinical Hearing Loss With Cognitive Performance. 亚临床听力损失与认知能力的关系
IF 7.8 Pub Date : 2020-01-01 DOI: 10.1001/jamaoto.2019.3375
Justin S Golub, Adam M Brickman, Adam J Ciarleglio, Nicole Schupf, José A Luchsinger
<p><strong>Importance: </strong>Age-related hearing loss (HL) is a common and treatable condition that has been associated with cognitive impairment. The level of hearing at which this association begins has not been studied to date.</p><p><strong>Objective: </strong>To investigate whether the association between hearing and cognition is present among individuals traditionally classified as having normal hearing.</p><p><strong>Design, setting, and participants: </strong>Cross-sectional study of 2 US epidemiologic studies (Hispanic Community Health Study [HCHS], 2008-2011, and National Health and Nutrition Examination Study [NHANES], 1999-2000, 2001-2002, and 2011-2012 cycles). The dates of analysis were November 2018 to August 2019. Multivariable generalized additive model (GAM) regression and linear regression were used to assess the association between HL (exposure) and cognition (outcome). Participants included 6451 individuals aged 50 years or older from the general Hispanic population (HCHS [n = 5190]) and the general civilian, noninstitutionalized US population (NHANES [n = 1261]).</p><p><strong>Exposures: </strong>Audiometric HL (4-frequency pure-tone average).</p><p><strong>Main outcomes and measures: </strong>Neurocognitive performance measured by the Digit Symbol Substitution Test (DSST) (score range, 0-113), Word Frequency Test (range, 0-49), Spanish-English Verbal Learning Test (SEVLT) 3 trials (range, 5-40), SEVLT recall (range, 0-15), and Six-Item Screener (range, 0-6); higher scores indicated better cognitive performance.</p><p><strong>Results: </strong>Among 6451 individuals, the mean (SD) age was 59.4 (6.1) years, and 3841 (59.5%) were women. The GAM regression showed a significant inverse association between hearing and cognition across the entire spectrum of hearing after adjusting for demographics and cardiovascular disease. In separate multivariable linear regressions stratified by the classic binary definition of HL, decreased hearing was independently associated with decreased cognition in adults with normal hearing (pure-tone average ≤25 dB) across all cognitive tests in the HCHS. For example in this group, a 10-dB decrease in hearing was associated with a clinically meaningful 1.97-point (95% CI, 1.18-2.75) decrease in score on the DSST. When using a stricter HL cut point (15 dB), an association was also present in NHANES. The associations between hearing and cognition were stronger or equivalent in individuals with normal hearing than among those with HL. For example, there was a 2.28-point (95% CI, 1.56-3.00) combined cohort DSST score decrease per 10-dB decrease among individuals with normal hearing vs a 0.97-point (95% CI, 0.20-1.75) decrease among those with HL, with a significant interaction term between continuous and binary hearing.</p><p><strong>Conclusions and relevance: </strong>An independent association was observed between cognition and subclinical HL. The association between hearing and cognition may be pre
重要性:老年性听力损失(HL)是一种常见的可治疗疾病,与认知障碍有关。迄今为止,还没有人研究过这种关联始于何种听力水平:调查听力与认知之间的关联是否存在于传统上被归类为听力正常的人群中:2项美国流行病学研究(西班牙裔社区健康研究[HCHS],2008-2011年;国家健康与营养调查研究[NHANES],1999-2000年、2001-2002年和2011-2012年周期)的横断面研究。分析日期为 2018 年 11 月至 2019 年 8 月。采用多变量广义相加模型(GAM)回归和线性回归评估HL(暴露)与认知(结果)之间的关联。参与者包括 6451 名年龄在 50 岁或 50 岁以上的人,他们来自西班牙裔普通人群(HCHS [n = 5190])和美国非住院普通平民人群(NHANES [n = 1261]):主要结果和测量指标:通过数字符号替换测试(DSST)(分值范围:0-113)、词频测试(分值范围:0-49)、西班牙语-英语语言学习测试(SEVLT)3次试验(分值范围:5-40)、SEVLT回忆(分值范围:0-15)和六项筛选器(分值范围:0-6)测量神经认知能力;得分越高,认知能力越强:在 6451 人中,平均(标清)年龄为 59.4(6.1)岁,女性为 3841 人(59.5%)。在对人口统计学和心血管疾病进行调整后,GAM 回归结果显示,在整个听力范围内,听力与认知之间存在显著的反向关系。在根据经典的二元听力定义进行的单独多变量线性回归中,听力下降与听力正常(纯音平均值≤25 dB)的成年人在 HCHS 的所有认知测试中的认知能力下降都有独立联系。例如,在该群体中,听力下降 10 分贝与 DSST 分数下降 1.97 分(95% CI,1.18-2.75)有临床意义。当使用更严格的听力切点(15 分贝)时,NHANES 中也出现了这种关联。与 HL 患者相比,听力正常者的听力与认知能力之间的关联更强或相当。例如,听力正常的人每降低 10 分贝,群组 DSST 综合得分就会降低 2.28 分(95% CI,1.56-3.00),而听力受损的人每降低 10 分贝,群组 DSST 综合得分就会降低 0.97 分(95% CI,0.20-1.75),连续听力和二元听力之间存在显著的交互项:认知能力与亚临床 HL 之间存在独立联系。听力与认知之间的关联可能比以往所理解的更早出现在 HL 患者身上。在研究治疗 HL 是否能预防认知功能受损和痴呆症时,应考虑采用比目前的 25 分贝阈值更低的阈值来定义 HL。
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引用次数: 0
“Justice's Beautiful Face”: Bob Sadoff and the Redemptive Promise of Therapeutic Jurisprudence “正义的美丽面孔”:鲍勃·萨多夫与治疗法学的救赎承诺
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000210
M. Perlin
Therapeutic jurisprudence (TJ) provides a framework for psycholegal analysis that has had no difficulty in attracting adherents within the law and a broad range of health-oriented disciplines. Although psychiatry has proven perhaps predictably less willing to embrace TJ, the work of Robert L. Sadoff, M.D. provides a heartening exception. Dr. Sadoff's career stands for many enlightening principles—not least of which is the redemptive promise of TJ.
治疗法学为心理分析提供了一个框架,它毫不费力地吸引了法律界和各种面向健康的学科的追随者。尽管精神病学已被证明不太愿意接受TJ,但医学博士罗伯特·l·萨多夫(Robert L. Sadoff)的研究提供了一个令人振奋的例外。萨多夫博士的职业生涯代表了许多具有启发性的原则,其中最重要的是TJ的救赎承诺。
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引用次数: 1
Bearing False Witness: Psychiatric Testimony in Nazi-Influenced Austria, 1928–1929 作伪证:受纳粹影响的奥地利的精神病学证词,1928-1929
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000207
K. Weiss
Dr. Robert Sadoff's teaching of honesty and integrity in forensic psychiatric work resonates both with current ethical principles and the ancient proscription against bearing false witness against one's fellow citizen. This article explores the misuse of psychiatric testimony in a 1928–1929 murder prosecution in Innsbruck, Austria. Amid clear undercurrents of Nazism, a Jewish youth found himself on trial for the murder of his father. Though there was no evidence that he was guilty, the expert testimony included distorted presentations of psychology and Freud's theory of the Oedipus complex. Freud and others protested the misuse of his work to convict the defendant, noting the difficulty in adapting psychoanalytic theory to legal settings. After 2 years in prison, the young man was set free, later becoming a world-renowned portrait photographer. Forensic professionals must continue to be vigilant in self-regulating the use of scientific information in legal settings.
罗伯特·萨多夫医生在法医精神病学工作中关于诚实和正直的教导,既符合当前的道德原则,也符合古代禁止对自己的同胞作伪证的禁令。这篇文章探讨了在奥地利因斯布鲁克1928-1929年谋杀起诉中滥用精神病学证词。在纳粹主义的明显暗流中,一个犹太青年发现自己因谋杀父亲而受审。虽然没有证据表明他有罪,但专家的证词包括扭曲的心理学陈述和弗洛伊德的俄狄浦斯情结理论。弗洛伊德和其他人抗议滥用他的工作来给被告定罪,指出精神分析理论很难适应法律环境。在监狱里呆了两年之后,这个年轻人被释放了,后来成为了世界知名的人像摄影师。法医专业人员必须继续保持警惕,在法律环境中对科学信息的使用进行自我调节。
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引用次数: 2
From the Journal of Psychiatry & Law Archives: Bernard L. Diamond. M.D. on “The Psychiatrist as Advocate” 来自《精神病学与法律档案杂志》:伯纳德·l·戴蒙德。医学博士谈《精神科医生的辩护》
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000204
K. Weiss, R. Sadoff
Dr. Bernard L. Diamond (1973) published the first article in the first issue of the Journal of Psychiatry & Law. Entitled “The Psychiatrist as Advocate,” it was a follow-up to his famous editorial, “The Fallacy of the Impartial Expert” (Diamond, 1959). Given the impossibility of total impartiality, the expert witness can still be ethical, but then undertake a form of activism. After nearly 40 years, we continue to reassess our boundaries as expert witnesses. In this article, the author has asked Dr. Robert L. Sadoff to comment on Dr. Diamond's ideas in the context of contemporary ethics.
Bernard L. Diamond博士(1973)在《精神病学与法律杂志》的第一期上发表了第一篇文章。题为《作为辩护人的精神科医生》,是他著名社论《公正专家的谬误》(戴蒙德,1959)的后续。鉴于不可能完全公正,专家证人仍然可以是道德的,但随后采取一种形式的激进主义。在将近40年之后,我们继续重新评估我们作为专家证人的界限。在这篇文章中,作者请罗伯特·l·萨多夫博士在当代伦理学的背景下评论戴蒙德博士的观点。
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引用次数: 1
Book Section: Essays and Reviews: Ethical Issues in Forensic Psychiatry: Minimizing Harm 书籍部分:论文和评论:法医精神病学的伦理问题:尽量减少伤害
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000211
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引用次数: 0
Assessment Instruments of Decision-Making Capacity 决策能力评估工具
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000209
Christopher W Racine, S. Billick
Capacity to consent to informed treatment decisions is an often overlooked, yet tremendously critical, aspect of modern medical practice. Despite its importance, research has shown that clinicians often fail to identify patients who lack capacity. Currently, other than a clinical psychiatric consultation and evaluation, there is no standardized method for determining whether a patient has capacity to make treatment decisions. Cognitive scales, such as the MMSE, may inform capacity evaluations but are neither sensitive nor specific. Accordingly, various clinical instruments have been developed to aid in the determination of capacity to consent to treatment. This is a review of several of these instruments. While there is no convincing evidence for the use of a particular scale, the CQ and ACE are easy to administer and can be efficiently utilized by clinicians to inform capacity assessment. While more time consuming to administer and score, the MacCAT-T also provides a comprehensive evaluation of key capacity domains.
在现代医疗实践中,知情同意治疗决定的能力是一个经常被忽视,但又极其关键的方面。尽管它很重要,但研究表明,临床医生往往无法识别缺乏能力的患者。目前,除了临床精神病学咨询和评估之外,没有标准化的方法来确定患者是否有能力做出治疗决定。认知量表,如MMSE,可以为能力评估提供信息,但既不敏感也不具体。因此,开发了各种临床工具,以帮助确定同意治疗的能力。这是对其中几种仪器的回顾。虽然没有令人信服的证据支持使用特定的量表,但CQ和ACE易于管理,临床医生可以有效地利用它们来进行能力评估。虽然管理和评分更耗时,但MacCAT-T还提供了对关键能力领域的全面评估。
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引用次数: 7
Criminal Law Standards in Civil Commitment 民事承诺中的刑法标准
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000205
R. Slovenko
The history of the hospitalization of persons with mental disorders has progressed in distinct stages over the course of the past two centuries. From Philippe Pinel's introduction of moral treatment principles, through the advent of professional psychiatry as a result of Sigmund Freud's innovations, through the move toward deinstitutionalization enabled by the discovery of new psychiatric medications, the groundwork was laid for the fourth and most recent of what can be seen as “revolutions” in institutional mental health care: the focus of both law and medicine on the parameters of the state's commitment power. This article addresses the function of the criminal procedure model in the context of civil commitment, its practical effects, and opportunities for continued reform.
在过去的两个世纪中,精神障碍患者住院治疗的历史经历了不同阶段的发展。从菲利普·皮内尔(Philippe Pinel)对道德治疗原则的介绍,到西格蒙德·弗洛伊德(Sigmund Freud)创新带来的专业精神病学的出现,再到新精神药物的发现带来的去机构化,第四次也是最近一次可以被视为机构精神卫生保健“革命”的基础奠定了基础:法律和医学都将重点放在国家承诺权力的参数上。本文论述了刑事诉讼模式在民事承诺背景下的功能、实践效果以及继续改革的机遇。
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引用次数: 4
Medication Noncompliance and Criminal Responsibility: Is the Insanity Defense Legitimate? 不遵医嘱与刑事责任:精神错乱辩护合法吗?
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000208
Zachary D. Torry, K. Weiss
Noncompliance with medication therapy and mental health care is prevalent among the mentally ill. Its multifactorial dynamics can include aspects of the illness itself, such as anosognosia. Noncompliance with medication can increase risk of violent or other criminal behavior, but the law currently does not recognize it as a factor in determining culpability. The legal test of insanity that focuses on a “defect of reason from disease of the mind” presumes that the disease was not self-induced. Noncompliance with medication and voluntary intoxication can both be seen as self-induced incapacities, but their adjudication is often quite different. A psychotic condition may be the basis of an excuse, whereas simple intoxication is not. The distinction is not only the obvious one of acts of omission (medication noncompliance) and acts of commission (voluntary intoxication). There are other complicating factors, such as the knowledge of the effects of noncompliance, the mental state prior to the noncompliance, and the presence of any conditions that would excuse or justify it. These and other considerations render the assignment of criminal responsibility for the noncompliant psychiatric offender complex. A possible solution to this would be the application of therapeutic jurisprudence to the noncompliant mentally ill offender.
不遵守药物治疗和精神卫生保健在精神病患者中很普遍。它的多因素动态可以包括疾病本身的各个方面,比如病感失认症。不遵守药物治疗会增加暴力或其他犯罪行为的风险,但法律目前并不承认这是确定有罪的一个因素。精神错乱的法律检验集中在“由精神疾病引起的理性缺陷”上,假定这种疾病不是自我诱发的。不遵守药物治疗和自愿中毒都可以被视为自我导致的丧失能力,但他们的裁决往往是完全不同的。精神状况可能是借口的基础,而单纯的醉酒则不是。区别不仅在于明显的不作为(不遵医嘱)和委托行为(自愿中毒)。还有其他复杂的因素,比如对不遵守的影响的了解,不遵守之前的精神状态,以及任何可以原谅或证明不遵守的条件的存在。这些和其他的考虑使得对不服从的精神病罪犯的刑事责任分配。一个可能的解决办法是将治疗法学应用于不服从的精神病罪犯。
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引用次数: 4
Notes on Contributors 投稿人说明
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000201
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引用次数: 0
On Honesty and Integrity in Forensic Science: A Snapshot of Robert L. Sadoff, M.D. 司法科学中的诚实和正直:罗伯特·萨多夫医学博士的快照
Pub Date : 2012-06-01 DOI: 10.1177/009318531204000203
F. Dattilio
This brief essay provides a snapshot of forensic psychiatrist Robert L. Sadoff and how his life has reflected the exemplification of honesty and integrity in the field of forensic science.
这篇简短的文章提供了法医精神病学家罗伯特·萨多夫的快照,以及他的生活如何反映了司法科学领域的诚实和正直的典范。
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引用次数: 0
期刊
The Journal of psychiatry & law
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