Pub Date : 2025-11-01DOI: 10.1016/j.apmr.2025.06.001
Fangbo Li PhD , Weifeng Pan PhD , Jiafu Huang PhD , Lianghao Zhu PhD , Xuecheng Li PhD
Objectives
To explore the impact of virtual reality (VR) intervention on motor function (MF) and activities of daily living (ADL) in children and adolescents with cerebral palsy (CP), and to identify effective VR intervention strategies.
Data Sources
Searches were conducted in PubMed, Wiley Online Library, Embase, Cochrane Library, and Web of Science (all collections).
Study Selection
All randomized controlled trials (RCTs) of VR intervention on MF and ADL in children and adolescents with CP.
Data Extraction
We conducted dual data abstraction, quality assessment, and strength of evidence. Outcomes include gait, balance, gross MF (GMF), ADL, and hand function.
Data Synthesis
This review encompassed 41 RCTs focusing on the use of VR intervention for children and adolescents with CP. The effect of VR intervention on gait (standardized mean difference [SMD]=0.52; 95% confidence interval [CI], 0.18-0.85) and GMF (SMD=0.76; 95% CI: 0.17, 1.34) has a moderate effect, while balance (SMD=1.1; 95% CI, 0.61-1.59), ADL (SMD=1.46; 95% CI, 0.71-2.2), and hand function (SMD=1.08; 95% CI, 0.17-2) have a great effect. Subgroup analysis reveals the influence of different intervention parameters on different functions. For example, balance is related to the intervention duration of >10 weeks, the frequency of 1-2 times per week, the Nintendo Wii platform, and nonimmersive VR.
Conclusion
Although the results show that VR intervention has a positive impact on MF and ADL, the high heterogeneity limits the stability of the conclusion. Future research needs to further explore the mechanism of VR intervention and try to set a reliable personalized intervention model.
{"title":"Effects of Virtual Reality Intervention on Motor Function and Activities of Daily Living of Children and Adolescents With Cerebral Palsy: A Systematic Review and Meta-analysis of Randomized Controlled Trials","authors":"Fangbo Li PhD , Weifeng Pan PhD , Jiafu Huang PhD , Lianghao Zhu PhD , Xuecheng Li PhD","doi":"10.1016/j.apmr.2025.06.001","DOIUrl":"10.1016/j.apmr.2025.06.001","url":null,"abstract":"<div><h3>Objectives</h3><div><span>To explore the impact of virtual reality (VR) intervention on motor function (MF) and activities of daily living (ADL) in children and adolescents with </span>cerebral palsy (CP), and to identify effective VR intervention strategies.</div></div><div><h3>Data Sources</h3><div>Searches were conducted in PubMed, Wiley Online Library, Embase, Cochrane Library, and Web of Science (all collections).</div></div><div><h3>Study Selection</h3><div>All randomized controlled trials (RCTs) of VR intervention on MF and ADL in children and adolescents with CP.</div></div><div><h3>Data Extraction</h3><div>We conducted dual data abstraction, quality assessment, and strength of evidence. Outcomes include gait, balance, gross MF (GMF), ADL, and hand function.</div></div><div><h3>Data Synthesis</h3><div>This review encompassed 41 RCTs focusing on the use of VR intervention for children and adolescents with CP. The effect of VR intervention on gait (standardized mean difference [SMD]=0.52; 95% confidence interval [CI], 0.18-0.85) and GMF (SMD=0.76; 95% CI: 0.17, 1.34) has a moderate effect, while balance (SMD=1.1; 95% CI, 0.61-1.59), ADL (SMD=1.46; 95% CI, 0.71-2.2), and hand function (SMD=1.08; 95% CI, 0.17-2) have a great effect. Subgroup analysis reveals the influence of different intervention parameters on different functions. For example, balance is related to the intervention duration of >10 weeks, the frequency of 1-2 times per week, the Nintendo Wii platform, and nonimmersive VR.</div></div><div><h3>Conclusion</h3><div>Although the results show that VR intervention has a positive impact on MF and ADL, the high heterogeneity limits the stability of the conclusion. Future research needs to further explore the mechanism of VR intervention and try to set a reliable personalized intervention model.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1735-1748"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.apmr.2025.08.004
T. Mark Campbell MD , Mohamed Thabet MSc , Gerd Melkus PhD , Gabriele Armbrecht MD , Guy Trudel MD
Objectives
To examine the effect of 60-days of bedrest on morphologic changes in the Achilles’ tendon using magnetic resonance imaging in 24 adults, and to explore the effects of artificial gravity (AG) by centrifugation intervention to counteract the effect of 60-days’ bedrest on such changes.
Design
Randomized controlled trial evaluating the effect of 30 minutes AG application, either continuously daily, or intermittently 6×5 minute sessions daily.
Setting
Experimental bedrest facility.
Participants
Healthy participants (N = 24) aged 24-55 years.
Interventions
continuous AG (N = 8), intermittent AG (N = 8).
Main Outcome Measures
Achilles’ tendon dimensions: depth, width, and cross-section area, volume at 2, 4, and 6 cm proximal to the tendon calcaneal insertion as baseline (baseline data collection), bedrest day-30 (HDT30) or 60 (HDT60), and during reambulation days 8, 90, and 450 (R8, R90, R450).
Results
Neither continuous nor intermittent AG interventions had any statistically significant effect on the Achilles’ tendon dimensions. No changes in the Achilles’ tendon were observed during bedrest. After 90-days of reambulation Achilles’ tendons were thinner at 2 cm with reduced volume at 2-4 cm and 4-6 cm and reduced volume 2-4 cm, 4-6 cm and 2-6 cm after 450-days of reambulation compared with baseline. Compared with day 8 of reambulation, Achilles’ tendons were thinner at 2, 4, and 6 cm from insertion and had decreased volume 2-4 cm, 4-6 cm and 2-6 cm after 450-days of reambulation.
Conclusions
This randomized controlled trial found no difference between control and AG interventions on Achilles’ tendon dimensions during 60-days of bedrest. Following 90- and 450-days of reambulation after bedrest, participants had thinner and smaller Achilles’ tendons, not prevented by AG. This study suggests that tendon changes can occur and persist after bedrest well into the reambulation phase and that clinicians should remain longitudinally vigilant for Achilles’ injury.
{"title":"Achilles’ Tendon Experiences Reduced Depth and Volume After 3 Months of Recovery From 60 Days Bedrest","authors":"T. Mark Campbell MD , Mohamed Thabet MSc , Gerd Melkus PhD , Gabriele Armbrecht MD , Guy Trudel MD","doi":"10.1016/j.apmr.2025.08.004","DOIUrl":"10.1016/j.apmr.2025.08.004","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the effect of 60-days of bedrest on morphologic changes in the Achilles’ tendon using magnetic resonance imaging in 24 adults, and to explore the effects of artificial gravity (AG) by centrifugation intervention to counteract the effect of 60-days’ bedrest on such changes.</div></div><div><h3>Design</h3><div>Randomized controlled trial evaluating the effect of 30 minutes AG application, either continuously daily, or intermittently 6×5 minute sessions daily.</div></div><div><h3>Setting</h3><div>Experimental bedrest facility.</div></div><div><h3>Participants</h3><div>Healthy participants (N = 24) aged 24-55 years.</div></div><div><h3>Interventions</h3><div>continuous AG (N = 8), intermittent AG (N = 8).</div></div><div><h3>Main Outcome Measures</h3><div>Achilles’ tendon dimensions: depth, width, and cross-section area, volume at 2, 4, and 6 cm proximal to the tendon calcaneal insertion as baseline (baseline data collection), bedrest day-30 (HDT30) or 60 (HDT60), and during reambulation days 8, 90, and 450 (R8, R90, R450).</div></div><div><h3>Results</h3><div>Neither continuous nor intermittent AG interventions had any statistically significant effect on the Achilles’ tendon dimensions. No changes in the Achilles’ tendon were observed during bedrest. After 90-days of reambulation Achilles’ tendons were thinner at 2 cm with reduced volume at 2-4 cm and 4-6 cm and reduced volume 2-4 cm, 4-6 cm and 2-6 cm after 450-days of reambulation compared with baseline. Compared with day 8 of reambulation, Achilles’ tendons were thinner at 2, 4, and 6 cm from insertion and had decreased volume 2-4 cm, 4-6 cm and 2-6 cm after 450-days of reambulation.</div></div><div><h3>Conclusions</h3><div>This randomized controlled trial found no difference between control and AG interventions on Achilles’ tendon dimensions during 60-days of bedrest. Following 90- and 450-days of reambulation after bedrest, participants had thinner and smaller Achilles’ tendons, not prevented by AG. This study suggests that tendon changes can occur and persist after bedrest well into the reambulation phase and that clinicians should remain longitudinally vigilant for Achilles’ injury.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1764-1769"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.apmr.2025.04.001
Jan Mathis Elling PhD , Nadine Sänger MSc , Betje Schwarz DrPH , Nico Seifert MA , Christian Hetzel PhD
Objective
To describe and explain the effect of the coronavirus disease 2019 pandemic and its related measures on return to work (RTW) outcomes after multimodal medical rehabilitation for musculoskeletal disorders.
Design
Retrospective cohort study.
Setting
Three cohorts: reference (rehabilitation and RTW prepandemic), pandemic 1 (rehabilitation prepandemic, RTW during pandemic), and pandemic 2 (rehabilitation and RTW during pandemic).
Participants
Individuals who underwent multimodal medical rehabilitation for musculoskeletal disorders through the German Pension Insurance system between January 2018 and December 2021 (N=688,127).
Interventions
Not applicable.
Main Outcome Measures
A successful and stable RTW was operationalized as having employment subject to social insurance contributions from 9 to 12 months after rehabilitation.
Results
Descriptive analysis revealed an RTW rate of 67.2% in the reference cohort, a slight decline in pandemic cohort 1 (66.3%), and a more pronounced decrease in pandemic cohort 2 (63.1%). In contrast, average marginal predictions from a logistic model including various covariates showed that both pandemic cohorts (63.8% and 64.4%) exhibited similarly reduced predicted probabilities of RTW compared with the reference cohort (66.5%). Individuals with sick leave durations exceeding 6 months, compared with those with shorter sick leaves, were more negatively affected by pandemic cohort 1; however, this effect recovered in pandemic cohort 2. The interaction between cohort and income did not show any amplifying effect of the pandemic.
Conclusions
The logistic model revealed no differences in predicted probabilities of RTW between pandemic cohort 2 and pandemic cohort 1, suggesting that orthopedic rehabilitation remained robust in maintaining RTW outcomes despite pandemic-related challenges. The findings offer mixed evidence regarding the question of whether the pandemic amplified preexisting barriers to RTW.
{"title":"Return to Work After Medical Rehabilitation for Musculoskeletal Disorders in Times of the COVID-19 Pandemic: A Retrospective Cohort Study","authors":"Jan Mathis Elling PhD , Nadine Sänger MSc , Betje Schwarz DrPH , Nico Seifert MA , Christian Hetzel PhD","doi":"10.1016/j.apmr.2025.04.001","DOIUrl":"10.1016/j.apmr.2025.04.001","url":null,"abstract":"<div><h3>Objective</h3><div>To describe and explain the effect of the coronavirus disease 2019 pandemic and its related measures on return to work (RTW) outcomes after multimodal medical rehabilitation for musculoskeletal disorders.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>Three cohorts: reference (rehabilitation and RTW prepandemic), pandemic 1 (rehabilitation prepandemic, RTW during pandemic), and pandemic 2 (rehabilitation and RTW during pandemic).</div></div><div><h3>Participants</h3><div>Individuals who underwent multimodal medical rehabilitation for musculoskeletal disorders through the German Pension Insurance system between January 2018 and December 2021 (N=688,127).</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>A successful and stable RTW was operationalized as having employment subject to social insurance contributions from 9 to 12 months after rehabilitation.</div></div><div><h3>Results</h3><div>Descriptive analysis revealed an RTW rate of 67.2% in the reference cohort, a slight decline in pandemic cohort 1 (66.3%), and a more pronounced decrease in pandemic cohort 2 (63.1%). In contrast, average marginal predictions from a logistic model including various covariates showed that both pandemic cohorts (63.8% and 64.4%) exhibited similarly reduced predicted probabilities of RTW compared with the reference cohort (66.5%). Individuals with sick leave durations exceeding 6 months, compared with those with shorter sick leaves, were more negatively affected by pandemic cohort 1; however, this effect recovered in pandemic cohort 2. The interaction between cohort and income did not show any amplifying effect of the pandemic.</div></div><div><h3>Conclusions</h3><div>The logistic model revealed no differences in predicted probabilities of RTW between pandemic cohort 2 and pandemic cohort 1, suggesting that orthopedic rehabilitation remained robust in maintaining RTW outcomes despite pandemic-related challenges. The findings offer mixed evidence regarding the question of whether the pandemic amplified preexisting barriers to RTW.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1685-1693"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.apmr.2025.05.017
Hui-Ju Young PhD , Byron Lai PhD , Jereme Wilroy PhD , Avery Vitemb MS , Shiori Tanaka PhD , Tapan S. Mehta PhD , Mohanraj Thirumalai PhD , James H. Rimmer PhD
Objective
To examine the effects of a 12-week online movement-to-music (eM2M) intervention on health outcomes in people with mobility disabilities.
Design
Two-arm randomized controlled trial.
Setting
Synchronous, online delivery over Zoom.
Participants
Adults (N=97) aged 18-70 and diagnosed with traumatic brain injury, stroke, multiple sclerosis, spinal cord injury, spina bifida, Parkinson, or cerebral palsy were randomized either to eM2M (n=48) or control (n=49).
Interventions
eM2M participants completed three 60-minute sessions weekly for 12 weeks, whereas controls maintained usual activities.
Main Outcome Measures
Primary measures included resting heart rate, heart rate recovery, and grip strength. Secondary measures included Short Physical Performance Battery (SPPB), timed Up and Go, PROMIS 10 Global Health Items, Ability to Participate in Social Roles and Activities Short Form 8a, and Godin Leisure Time Exercise Questionnaire. Participants were assessed at baseline and postintervention, with intent-to-treat mixed-model analysis of covariance as primary analyses.
Results
After adjusting for baseline and mobility groups, there was no significant between-group difference in resting heart rate postintervention, though eM2M had a greater reduction in heart rate at minute-1 recovery (LSM=33.7%, P=.04). No difference was observed in dominant hand grip strength, whereas controls showed a significantly greater increase in nondominant grip strength compared to eM2M (LSM=−1.76kg, P=.03). In contrast, eM2M demonstrated significant improvements in overall SPPB (LSM=0.52, P=.048), gait speed (LSM=0.32, P=.02), and both physical (LSM difference=2.08, P=.04) and mental (LSM=2.22, P=.02) health compared to controls. No group differences were observed in social participation. After removing outliers, eM2M showed a significant increase in physical activity compared to controls (LSM=11.55, P=.02).
Conclusions
Movement-to-music delivered online may improve cardiorespiratory fitness, mobility, quality of life, and physical activity in people with mobility disabilities.
{"title":"Effects of a Teleexercise Movement-to-Music Intervention on Health Outcomes in Individuals With Mobility Disabilities: A Randomized Controlled Trial","authors":"Hui-Ju Young PhD , Byron Lai PhD , Jereme Wilroy PhD , Avery Vitemb MS , Shiori Tanaka PhD , Tapan S. Mehta PhD , Mohanraj Thirumalai PhD , James H. Rimmer PhD","doi":"10.1016/j.apmr.2025.05.017","DOIUrl":"10.1016/j.apmr.2025.05.017","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the effects of a 12-week online movement-to-music (eM2M) intervention on health outcomes in people with mobility disabilities.</div></div><div><h3>Design</h3><div>Two-arm randomized controlled trial.</div></div><div><h3>Setting</h3><div>Synchronous, online delivery over Zoom.</div></div><div><h3>Participants</h3><div>Adults (N=97) aged 18-70 and diagnosed with traumatic brain injury, stroke, multiple sclerosis, spinal cord injury, spina bifida, Parkinson, or cerebral palsy were randomized either to eM2M (n=48) or control (n=49).</div></div><div><h3>Interventions</h3><div>eM2M participants completed three 60-minute sessions weekly for 12 weeks, whereas controls maintained usual activities.</div></div><div><h3>Main Outcome Measures</h3><div>Primary measures included resting heart rate, heart rate recovery, and grip strength. Secondary measures included Short Physical Performance Battery (SPPB), timed Up and Go, PROMIS 10 Global Health Items, Ability to Participate in Social Roles and Activities Short Form 8a, and Godin Leisure Time Exercise Questionnaire. Participants were assessed at baseline and postintervention, with intent-to-treat mixed-model analysis of covariance as primary analyses.</div></div><div><h3>Results</h3><div>After adjusting for baseline and mobility groups, there was no significant between-group difference in resting heart rate postintervention, though eM2M had a greater reduction in heart rate at minute-1 recovery (LSM=33.7%, <em>P</em>=.04). No difference was observed in dominant hand grip strength, whereas controls showed a significantly greater increase in nondominant grip strength compared to eM2M (LSM=−1.76kg, <em>P</em>=.03). In contrast, eM2M demonstrated significant improvements in overall SPPB (LSM=0.52, <em>P</em>=.048), gait speed (LSM=0.32, <em>P</em>=.02), and both physical (LSM difference=2.08, <em>P</em>=.04) and mental (LSM=2.22, <em>P</em>=.02) health compared to controls. No group differences were observed in social participation. After removing outliers, eM2M showed a significant increase in physical activity compared to controls (LSM=11.55, <em>P</em>=.02).</div></div><div><h3>Conclusions</h3><div>Movement-to-music delivered online may improve cardiorespiratory fitness, mobility, quality of life, and physical activity in people with mobility disabilities.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1654-1664"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.apmr.2025.04.004
Arianne S. Gravesteijn MSc, PT , Heleen Beckerman PhD , Marloes Willig BSc , Hanneke E. Hulst PhD , Vincent de Groot PhD, MD , Brigit A. de Jong PhD, MD
Objective
To explore the natural fluctuations in cardiovascular risk factors over a 16-week extended baseline period and to investigate the effect of a 16-week progressive resistance training intervention on cardiovascular risk factors in people living with secondary progressive multiple sclerosis.
Design
Secondary analysis of a single-arm nonrandomized clinical trial with extended baseline.
Setting
Outpatient physiotherapy and rehabilitation clinics.
Participants
30 people living with secondary progressive multiple sclerosis (mean age, 54 years; 67% female).
Interventions
16-week progressive resistance training intervention (PRT).
Main Outcome Measures
Systematic COronary Risk Estimation (SCORE), Framingham Risk Score, and individual cardiovascular risk factors (ie, anthropometrics, blood pressure, lipids and lipoproteins, and glycemic controls markers) measured at week 0 (baseline), week 16 (extended baseline), and week 32 (post-PRT).
Results
Despite significant improvement in muscle strength after PRT, PRT did not yield statistically significant or clinically relevant changes in any of the cardiovascular risk parameters. Natural fluctuations during the extended baseline period were small, with intraclass correlation coefficient (ICC) values ranging from 0.717 to 0.983, except for systolic blood pressure (ICC: 0.471).
Conclusions
Our findings indicate that a 16-week PRT program did not lead to improvements in cardiovascular risk among individuals with secondary progressive multiple sclerosis. The observed natural fluctuations in cardiovascular risk factors were small in this population, with overall baseline cardiovascular risk comparable to Dutch norms.
{"title":"Effects of Progressive Resistance Training on Cardiovascular Risk Factors in People With Progressive Multiple Sclerosis","authors":"Arianne S. Gravesteijn MSc, PT , Heleen Beckerman PhD , Marloes Willig BSc , Hanneke E. Hulst PhD , Vincent de Groot PhD, MD , Brigit A. de Jong PhD, MD","doi":"10.1016/j.apmr.2025.04.004","DOIUrl":"10.1016/j.apmr.2025.04.004","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the natural fluctuations in cardiovascular risk factors over a 16-week extended baseline period and to investigate the effect of a 16-week progressive resistance training intervention on cardiovascular risk factors in people living with secondary progressive multiple sclerosis.</div></div><div><h3>Design</h3><div>Secondary analysis of a single-arm nonrandomized clinical trial with extended baseline.</div></div><div><h3>Setting</h3><div>Outpatient physiotherapy and rehabilitation clinics.</div></div><div><h3>Participants</h3><div>30 people living with secondary progressive multiple sclerosis (mean age, 54 years; 67% female).</div></div><div><h3>Interventions</h3><div>16-week progressive resistance training intervention (PRT).</div></div><div><h3>Main Outcome Measures</h3><div>Systematic COronary Risk Estimation (SCORE), Framingham Risk Score, and individual cardiovascular risk factors (ie, anthropometrics, blood pressure, lipids and lipoproteins, and glycemic controls markers) measured at week 0 (baseline), week 16 (extended baseline), and week 32 (post-PRT).</div></div><div><h3>Results</h3><div>Despite significant improvement in muscle strength after PRT, PRT did not yield statistically significant or clinically relevant changes in any of the cardiovascular risk parameters. Natural fluctuations during the extended baseline period were small, with intraclass correlation coefficient (ICC) values ranging from 0.717 to 0.983, except for systolic blood pressure (ICC: 0.471).</div></div><div><h3>Conclusions</h3><div>Our findings indicate that a 16-week PRT program did not lead to improvements in cardiovascular risk among individuals with secondary progressive multiple sclerosis. The observed natural fluctuations in cardiovascular risk factors were small in this population, with overall baseline cardiovascular risk comparable to Dutch norms.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1694-1702"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/S0003-9993(25)00947-5
{"title":"Ed Board page","authors":"","doi":"10.1016/S0003-9993(25)00947-5","DOIUrl":"10.1016/S0003-9993(25)00947-5","url":null,"abstract":"","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Page A10"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.apmr.2025.03.046
Anson B. Rosenfeldt PT, DPT, MBA , Amanda L. Penko PhD , Amy Elizabeth Jansen MPH , Cielita Lopez-Lennon PT, DPT , Eric Zimmerman MS , Peter B. Imrey PhD , Tamanna K. Singh MD , Leland E. Dibble PT, PhD , Jay L. Alberts PhD
Objective
To derive and evaluate an alternative equation to estimate maximal heart rate in persons with Parkinson disease (PD) in the absence of structured exercise testing using observed maximal heart rate data from a maximal cardiopulmonary exercise test (CPET) and basic demographic and clinical data.
Design
Baseline data from a randomized controlled trial.
Setting
Academic Medical Center.
Participants
Eighty-two persons with mild-to-moderate PD who completed a CPET.
Interventions
Not applicable.
Main Outcome Measures
A linear regression model was fit to maximal heart rate from CPET using the relaxed least absolute shrinkage and selection operator (lasso) and 7 readily clinically accessible candidate covariables. Model fit was assessed by leave-one-out cross-validation. Maximal heart rates from the CPET were compared with estimates from the regression model and from 2 traditional age-based maximal heart rate estimators: (220 – age) and [208 − (0.7 × age)].
Results
The regression-based heart rate estimator was [166 − (1.15 × age) + (0.60 × resting heart rate)] and most closely fit the observed maximal heart rate from the CPET. The (220 − age) and [208 − (0.7 × age)] equations overestimated maximal heart rate for 88% and 94% of the participants, respectively. The mean square error of the regression-based estimator was 63% and 75% lower than those of the 2 traditional age-based estimators, respectively.
Conclusions
Overestimating maximal heart rate generates prescribed target heart rate zones that are likely unachievable during aerobic exercise. The proposed regression-based maximal heart rate estimator most closely fit observed maximal heart rates from the CPET. Adoption of this estimator, based on both age and resting heart rate, may improve estimated maximal heart rate accuracy and thus provide more appropriate and achievable exercise heart rate zones for persons with PD in the absence of a CPET.
{"title":"Refining Maximal Heart Rate Estimation to Enhance Exercise Recommendations for Persons With Parkinson Disease","authors":"Anson B. Rosenfeldt PT, DPT, MBA , Amanda L. Penko PhD , Amy Elizabeth Jansen MPH , Cielita Lopez-Lennon PT, DPT , Eric Zimmerman MS , Peter B. Imrey PhD , Tamanna K. Singh MD , Leland E. Dibble PT, PhD , Jay L. Alberts PhD","doi":"10.1016/j.apmr.2025.03.046","DOIUrl":"10.1016/j.apmr.2025.03.046","url":null,"abstract":"<div><h3>Objective</h3><div>To derive and evaluate an alternative equation to estimate maximal heart rate in persons with Parkinson disease (PD) in the absence of structured exercise testing using observed maximal heart rate data from a maximal cardiopulmonary exercise test (CPET) and basic demographic and clinical data.</div></div><div><h3>Design</h3><div>Baseline data from a randomized controlled trial.</div></div><div><h3>Setting</h3><div>Academic Medical Center.</div></div><div><h3>Participants</h3><div>Eighty-two persons with mild-to-moderate PD who completed a CPET.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>A linear regression model was fit to maximal heart rate from CPET using the relaxed least absolute shrinkage and selection operator (lasso) and 7 readily clinically accessible candidate covariables. Model fit was assessed by leave-one-out cross-validation. Maximal heart rates from the CPET were compared with estimates from the regression model and from 2 traditional age-based maximal heart rate estimators: (220 – age) and [208 − (0.7 × age)].</div></div><div><h3>Results</h3><div>The regression-based heart rate estimator was [166 − (1.15 × age) + (0.60 × resting heart rate)] and most closely fit the observed maximal heart rate from the CPET. The (220 − age) and [208 − (0.7 × age)] equations overestimated maximal heart rate for 88% and 94% of the participants, respectively. The mean square error of the regression-based estimator was 63% and 75% lower than those of the 2 traditional age-based estimators, respectively.</div></div><div><h3>Conclusions</h3><div>Overestimating maximal heart rate generates prescribed target heart rate zones that are likely unachievable during aerobic exercise. The proposed regression-based maximal heart rate estimator most closely fit observed maximal heart rates from the CPET. Adoption of this estimator, based on both age and resting heart rate, may improve estimated maximal heart rate accuracy and thus provide more appropriate and achievable exercise heart rate zones for persons with PD in the absence of a CPET.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1680-1684"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to evaluate the effectiveness of a traditional cardiac rehabilitation (CR) program compared with an augmented program that integrates traditional CR with face-to-face training sessions and remote assistance facilitated through an application based on the knowledge, attitudes, and practices model for individuals undergoing coronary artery bypass graft (CABG) surgery.
Design
A randomized controlled trial with a blinded outcome assessment was used (IRCT20230902059333N1).
Setting
A major heart center in a middle-income country.
Participants
Of the 80 patients referred to the CR program during the study, 70 patients (N=70) were successfully enrolled, reaching the target sample size. Participants were randomly assigned in a 1:1 ratio, resulting in 35 patients per group.
Interventions
In addition to traditional CR, patients participated in 4 in-person training sessions throughout the rehabilitation process and received 3 months of follow-up support via the app after completing the program.
Main Outcome Measures
Medication adherence and self-efficacy were assessed before the initiation of CR, immediately after its completion, and 3 months postcompletion.
Results
There were no significant demographic differences between the intervention and control groups. However, throughout the study, significant differences emerged in favor of the 3 groups concerning medication adherence and self-efficacy (P<.001). The intervention group showed substantial and continuous improvements in medication adherence and self-efficacy scores, which were evident from the 1st month and persisted over time.
Conclusions
Implementing a blended learning approach in CR has demonstrated benefits in medication adherence and self-efficacy, highlighting the necessity for further research and clinical application.
{"title":"Role of Blended Learning in Enhancing Self-Efficacy and Medication Adherence in Cardiac Rehabilitation for Individuals Undergoing Coronary Artery Bypass Surgery: A Randomized Control Trial","authors":"Ghazal Veisi MSc , Fatemeh Pakrad PhD , Robbert Gobbens PhD , Younes Mohammadi PhD , Lobat Majidi MD","doi":"10.1016/j.apmr.2025.05.011","DOIUrl":"10.1016/j.apmr.2025.05.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the effectiveness of a traditional cardiac rehabilitation (CR) program compared with an augmented program that integrates traditional CR with face-to-face training sessions and remote assistance facilitated through an application based on the knowledge, attitudes, and practices model for individuals undergoing coronary artery bypass graft (CABG) surgery.</div></div><div><h3>Design</h3><div>A randomized controlled trial with a blinded outcome assessment was used (IRCT20230902059333N1).</div></div><div><h3>Setting</h3><div>A major heart center in a middle-income country.</div></div><div><h3>Participants</h3><div>Of the 80 patients referred to the CR program during the study, 70 patients (N=70) were successfully enrolled, reaching the target sample size. Participants were randomly assigned in a 1:1 ratio, resulting in 35 patients per group.</div></div><div><h3>Interventions</h3><div>In addition to traditional CR, patients participated in 4 in-person training sessions throughout the rehabilitation process and received 3 months of follow-up support via the app after completing the program.</div></div><div><h3>Main Outcome Measures</h3><div>Medication adherence and self-efficacy were assessed before the initiation of CR, immediately after its completion, and 3 months postcompletion.</div></div><div><h3>Results</h3><div>There were no significant demographic differences between the intervention and control groups. However, throughout the study, significant differences emerged in favor of the 3 groups concerning medication adherence and self-efficacy (<em>P</em><.001). The intervention group showed substantial and continuous improvements in medication adherence and self-efficacy scores, which were evident from the 1st month and persisted over time.</div></div><div><h3>Conclusions</h3><div>Implementing a blended learning approach in CR has demonstrated benefits in medication adherence and self-efficacy, highlighting the necessity for further research and clinical application.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1645-1653"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.apmr.2025.03.043
Jessica Kersey PhD, OTR/L , Christian Le , Emily Evans PT, PhD , Zaccheus J. Ahonle PhD, CRC , Patricia Garcia PsyD, HSPP , Anthony H. Lequerica PhD , Devina Kumar PhD, MSc, PT , Devan Parrott PhD
Objective
To describe the recruitment and retention practices of brain injury rehabilitation researchers and factors affecting the inclusion of racially and ethnically diverse research participants.
Design
Ethnographic study using surveys and qualitative interviews.
Setting
Virtual.
Participants
Eleven investigators (N=11) who published cognitive rehabilitation intervention studies.
Interventions
Not applicable.
Main Outcome Measures
Participants completed a survey describing strategies that have shown promise for the recruitment and retention of diverse participants. They then completed a qualitative interview to describe their priorities, the perceived effectiveness of their practices, and the challenges to recruiting representative samples. Interviews were analyzed using thematic analysis.
Results
Investigators reported moderate confidence in their knowledge of promising recruitment strategies but low confidence in implementing those strategies. Qualitative themes were balancing competing recruitment and retention priorities, building relationships with participants and communities, and research infrastructure and policies. Key factors influencing recruitment and retention practices included research study and research team characteristics, institutional infrastructure and policies, local contextual factors, and national academic community infrastructure and norms.
Conclusions
Brain injury rehabilitation research faces significant challenges in achieving representation of racially and ethnically diverse participants. Systemic changes are needed at the study, institutional, and national levels to support more equitable clinical trial enrollment and reduce health disparities for marginalized brain injury survivors.
{"title":"Inclusion of Racially and Ethnically Diverse Samples in Cognitive Rehabilitation Research: An Ethnographic Study of Recruitment and Retention Practices","authors":"Jessica Kersey PhD, OTR/L , Christian Le , Emily Evans PT, PhD , Zaccheus J. Ahonle PhD, CRC , Patricia Garcia PsyD, HSPP , Anthony H. Lequerica PhD , Devina Kumar PhD, MSc, PT , Devan Parrott PhD","doi":"10.1016/j.apmr.2025.03.043","DOIUrl":"10.1016/j.apmr.2025.03.043","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the recruitment and retention practices of brain injury rehabilitation researchers and factors affecting the inclusion of racially and ethnically diverse research participants.</div></div><div><h3>Design</h3><div>Ethnographic study<span> using surveys and qualitative interviews.</span></div></div><div><h3>Setting</h3><div>Virtual.</div></div><div><h3>Participants</h3><div>Eleven investigators (N=11) who published cognitive rehabilitation intervention studies.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>Participants completed a survey describing strategies that have shown promise for the recruitment and retention of diverse participants. They then completed a qualitative interview to describe their priorities, the perceived effectiveness of their practices, and the challenges to recruiting representative samples. Interviews were analyzed using thematic analysis.</div></div><div><h3>Results</h3><div>Investigators reported moderate confidence in their knowledge of promising recruitment strategies but low confidence in implementing those strategies. Qualitative themes were balancing competing recruitment and retention priorities, building relationships with participants and communities, and research infrastructure and policies. Key factors influencing recruitment and retention practices included research study and research team characteristics, institutional infrastructure and policies, local contextual factors, and national academic community infrastructure and norms.</div></div><div><h3>Conclusions</h3><div><span>Brain injury rehabilitation research faces significant challenges in achieving representation of racially and ethnically diverse participants. Systemic changes are needed at the study, institutional, and national levels to support more equitable clinical trial enrollment and reduce </span>health disparities for marginalized brain injury survivors.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1665-1671"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/S0003-9993(25)00959-1
{"title":"Archives Supplements","authors":"","doi":"10.1016/S0003-9993(25)00959-1","DOIUrl":"10.1016/S0003-9993(25)00959-1","url":null,"abstract":"","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 11","pages":"Pages 1785-1787"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145398119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}