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Minimal Important Changes of Common Outcome Measures of Physical Function in Individuals With Knee Osteoarthritis: A Prospective Clinical Study 膝骨关节炎患者身体功能常见结局指标的微小重要变化:一项前瞻性临床研究。
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.04.016
Rebecca B. Ramalho PT , Thais C. Chaves PhD , Berend Terluin PhD , Luiz F.A. Selistre PhD

Objectives

To investigate the minimal important change (MIC) for the 40-meter Fast Paced Walk Test (40m FPWT), 30-second Chair Stand Test (30s CST), 11-step Stair Climb Test (SCT), and Western Ontario and McMaster Universities Osteoarthritis Index – Physical Function subscale (WOMAC-PF) in individuals with knee osteoarthritis according to 3 methods described in the literature.

Design

A prospective clinical study.

Setting

Department of Physiotherapy at the Federal University of São Carlos (Brazil).

Participants

A total of one hundred and seven (N=107) participants.

Interventions

Not applicable.

Main Outcome Measures

Performance-based tests and WOMAC-PF were applied. After 6 months, the Global Perceived Effect (GPE) scale was used to evaluate changes in physical function. A GPE cutoff score was established to categorize participants as improved or not improved. The MICmean, MICreceiver operating characteristic (ROC), and MICadjusted were calculated. Anchor reliability was assessed through longitudinal confirmatory factor analysis.

Results

Of the 80 study participants, 19 were in the improved group. The MICmean of the subgroups ranged from 0.07 to 0.29 m/s for the 40m FPWT, 2.07 to 5.29 stands for the 30s CST, 2.14 to 5.58 seconds for the 11-step SCT, and 4.21 to 27 for the WOMAC-PF. The MICROC values were 0.14 m/s for the 40m FPWT, 1.5 stands for the 30s CST, 1.79 seconds for the 11-step SCT, and 4.5 for the WOMAC-PF. The MICadjusted values were 0.10 m/s for the 40m FPWT, 0.7 stands for the 30s CST, 4.0 seconds for the 11-step SCT, and 12.8 for the WOMAC-PF.

Conclusions

The MICadjusted method considers both the proportion of improved patients and the reliability of transition ratings, making it preferable to MICmean and MICROC. However, more high-quality studies are needed to assess its performance in samples with floor or ceiling effects.
目的:根据文献中描述的三种方法,研究40米快步步行测试(40m FPWT)、30秒椅子站立测试(30s CST)、11步爬楼梯测试(11步SCT)和西安大略省和麦克马斯特大学骨关节炎指数-身体功能量表(WOMAC-PF)在膝骨关节炎(KOA)患者中的最小重要变化(MIC)。设计:前瞻性临床研究。地点:巴西奥卡洛斯联邦大学物理治疗系研究对象:共107名研究对象。干预措施:不适用。主要结局指标:采用基于性能的测试和WOMAC-PF。6个月后,使用GPE量表评估身体功能的变化。建立GPE分界点评分,将参与者分为改善或未改善。计算MICmean、MICROC和MICadjusted。通过纵向验证性因子分析评估锚定信度。结果:在80名研究参与者中,有19人处于改善组。40m FPWT的MICmean为0.07 ~ 0.29 m/s, 30 m CST为2.07 ~ 5.29 m/s, 11步SCT为2.14 ~ 5.58s, WOMAC-PF为4.21 ~ 27 m/s。40m FPWT的MICROC值为0.14 m/s, 30s CST为1.5,11步SCT为1.79s, WOMAC-PF为4.5。40m FPWT的mic调整值为0.10 m/s, 30s CST为0.7,11步SCT为4.0 m/s, WOMAC-PF为12.8。结论:mic调整后的方法兼顾了改善患者的比例和过渡评分的可靠性,优于MICmean和MICROC。然而,需要更多高质量的研究来评估其在具有地板或天花板效应的样本中的性能。
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引用次数: 0
Clinical Utility of Remote Teleassessment of Motor Performance in Individuals With Neurologic Disabilities: A COSMIN Systematic Review 神经功能障碍患者运动表现远程评估的临床应用:一项COSMIN系统综述。
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.07.013
Andrea Baroni PhD , Gabriele Perachiotti PT , Andrea Carpineto PT , Giulia Fregna MSc , Annibale Antonioni MD , Maria E. Flacco PhD , Sofia Straudi PhD

Objective

To investigate the feasibility and measurement properties of measurement tools for remote evaluation of motor performance in people with neurologic conditions requiring only synchronous or asynchronous video conferencing without sensors or other complex technological tools.

Data Sources

A systematic search was conducted in PubMed, Embase, the Cumulative Index for Nursing and Allied Health Literature (CINHAL), and ScienceDirect. The search strategy included keywords related to any neurologic population, telerehabilitation, and motor performance outcome measure; papers in Italian or English language on adults were included, without time restrictions.

Study Selection

We included studies reporting data of at least one measurement property between reliability, validity, feasibility, or acceptability of measurement tools for remote motor assessment in neurologic disorders. We excluded studies that used wearable technologies, smartphones, or mobile applications. After duplicate removal, 2530 records were screened. Of the 461 remaining papers, 26 met the inclusion criteria and were included in the systematic review.

Data Extraction

Two independent reviewers extracted data from the included records, evaluated the risk of bias of the studies using the Consensus-based Standards for the selection of health Measurement Instruments tool, and applied the criteria for good measurement properties and clinical utility. Discordance was solved through discussion with a third reviewer.

Data Synthesis

Twenty-nine measurement tools were identified, and a narrative synthesis was conducted because of the heterogeneity of the included studies. The Fugl-Meyer Assessment for the Lower and Upper Extremity and the Tinetti Performance-Oriented Mobility Assessment Balance were suggested for the remote evaluation of people with stroke, whereas the Five Times Sit-to-Stand Test, the Nine-Hole Peg Test, and the Timed 25-Foot Walk Test were suggested for people with multiple sclerosis.

Conclusions

Several measurement tools have been identified for remote evaluation of motor performance in people with neurologic disorders, but few of them can be suggested for clinical and scientific purposes. A higher methodological quality of studies would support the use of these tools in clinical practice.
目的:探讨仅需要同步或异步视频会议,无需传感器或其他复杂技术工具即可远程评估神经系统疾病患者运动表现的测量工具的可行性和测量特性。数据来源:系统检索PubMed、Embase、CINHAL和ScienceDirect。搜索策略包括与任何神经学人群、远程康复和运动表现结果测量相关的关键词;用意大利语或英语写的关于成人的论文也包括在内,没有时间限制。研究选择:我们纳入了报告在神经系统疾病远程运动评估测量工具的可靠性、有效性、可行性或可接受性之间至少有一种测量特性的研究。我们排除了使用可穿戴技术、智能手机或移动应用程序的研究。删除重复后,筛选了2530条记录。在剩余的461篇论文中,26篇符合纳入标准,被纳入系统评价。数据提取:两名独立的审稿人从纳入的记录中提取数据,使用COSMIN工具评估研究的偏倚风险,并应用良好的测量特性和临床实用性标准。通过与第三审稿人讨论解决不一致。数据综合:确定了29种测量工具,由于纳入研究的异质性,进行了叙述性综合。脑卒中患者的远程评价建议采用Fugl-Meyer下肢和上肢评估和Tinetti运动平衡评估,而多发性硬化患者的远程评价建议采用五次坐立测试、九孔Peg测试和定时25英尺步行测试。已经确定了几种测量工具,用于远程评估神经系统疾病患者的运动表现,但很少有人可以建议用于临床和科学目的。更高方法学质量的研究将支持在临床实践中使用这些工具。
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引用次数: 0
Ed Board page 教育版面
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/S0003-9993(25)01008-1
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引用次数: 0
Moderating Effects of Clinical and Social Factors on Fatigue Improvement After an Online Peer-Led Fatigue Self-management Intervention in People With Systemic Sclerosis: A Secondary Analysis of a Randomized Controlled Trial 临床和社会因素对系统性硬化症患者在线同伴引导的疲劳自我管理干预后疲劳改善的调节作用:一项随机对照试验的二次分析
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.05.002
Yen T. Chen PhD , Nirali Shah PhD , Afton L. Hassett PsyD , Suiyuan Huang MPH , Dinesh Khanna MD, MSc , Susan L. Murphy ScD

Objective

To examine moderators of intervention effects in fatigue from a randomized controlled trial comparing an online peer-led fatigue self-management intervention to a waitlist control in people with systemic sclerosis (SSc).

Design

Secondary analysis of a 12-week, parallel, single-blind randomized controlled trial.

Setting

Community.

Participants

Adults with SSc with moderate to severe fatigue (N=173) recruited from SSc specialty centers, a registry, and social media.

Interventions

A 12-week, online, peer-led fatigue self-management intervention was randomized in a 2:1 ratio: intervention (n=115) and waitlist control (n=58).

Main Outcome Measures

The outcome measure was change in the Functional Assessment of Chronic Illness Therapy-Fatigue scale assessed at baseline, week 6, and week 12. Potential moderators assessed at baseline included demographic, clinical, psychological, and social variables.

Results

Baseline levels of informational support moderated the treatment effect to predict change in fatigue at week 12 (P=.015). Participants who had average to high levels of informational support at baseline reported greater improvements in fatigue at week 12 compared with their counterparts in both treatment groups, whereas the between-moderator difference in the intervention group is significantly larger than in the waitlist control. No other variables were found to significantly moderate the outcomes.

Conclusions

Participants with baseline average to high informational support experienced greater improvements in fatigue at week 12 compared with their counterparts, particularly in the intervention group. This suggests that higher informational support may enhance coping and emotional reassurance. Future research could tailor fatigue interventions based on baseline informational support to optimize treatment efficacy in diverse SSc populations.
目的:通过一项随机对照试验(RCT)比较系统性硬化症(SSc)患者在线同伴引导的疲劳自我管理干预和候补控制,研究干预对疲劳影响的调节因子。设计:对一项为期12周的平行单盲随机对照试验进行二次分析。社区参与者:从SSc专业中心、注册中心和社交媒体中招募患有中度至重度疲劳的SSc成人(N=173)。干预:一项为期12周的在线同伴领导的疲劳自我管理干预以2:1的比例随机化:干预组(n=115)和候补组(n=58)。主要结果测量:结果测量是在基线、第6周和第12周评估的慢性疾病治疗功能评估-疲劳量表的变化。基线时评估的潜在调节因素包括人口统计学、临床、心理和社会变量。结果:基线水平的信息支持调节了治疗效果,以预测第12周的疲劳变化(p= 0.015)。在基线时获得平均到高水平信息支持的参与者报告说,与两个治疗组的参与者相比,在第12周时疲劳得到了更大的改善,而干预组的调节因子间差异明显大于等候名单对照组。没有发现其他变量显著调节结果。结论:基线平均到高信息支持的参与者在第12周与他们的同行相比,在疲劳方面有更大的改善,特别是在干预组。这表明更高的信息支持可能会增强应对和情感安慰。未来的研究可以根据基线信息支持来定制疲劳干预措施,以优化不同SSc人群的治疗效果。
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引用次数: 0
Development and Validation of a Prognostic Model for Independent Walking in Children With Cerebral Palsy Based on Machine Learning 基于机器学习的脑瘫儿童独立行走预后模型的开发与验证。
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.05.006
Wang Yiwen MD, Yang Yonghui MD

Objective

To develop and validate machine learning-based models for predicting independent walking ability in children with cerebral palsy (CP).

Design

Retrospective cohort study.

Setting

Data were collected from a national CP registry platform and follow-up assessments were conducted through telephone interviews.

Participants

Children with CP (n=807) registered between January 2016 and December 2020, with follow-up data collected from October 2022 to March 2023.

Interventions

Not applicable.

Main Outcome Measures

The primary outcome was independently walking before the age of 6 years.

Results

Among the 807 participants, 561 (69.5%) achieved independent walking. Univariate Cox regression identified several predictive factors, including neonatal asphyxia, bilirubin encephalopathy, Gross Motor Function Classification System level before age of 2 years, age of independent sitting, type of CP, magnetic resonance imaging classification, Gross Motor Function Measure-88 scores, epilepsy, intellectual disability, early preterm birth, and very low birth weight (P<.05). Machine learning models demonstrated excellent predictive performance, with logistic regression achieving the highest area under the curve (AUC=0.947), followed by XGBoost (AUC=0.946) and multilayer perceptron (AUC=0.945). Cox proportional hazard models identified key predictors for the timing of independent walking, with a nomogram constructed for clinical application. Internal validation confirmed model reliability, although calibration curves indicated potential overestimation for ages 5-6 years.

Conclusions

Machine learning models accurately predict independent walking ability in children with CP, although calibration analyses indicated potential overestimation for children aged 5-6 years. The proposed nomogram provides clinicians with an interpretable tool for personalized prognosis. Although internal validation demonstrated excellent performance, future external validation in multicenter cohorts will be critical to confirm generalizability.
目的:建立并验证基于机器学习的预测脑瘫儿童独立行走能力的模型。研究背景:数据从国家脑瘫登记平台收集,并通过电话访谈进行随访评估。参与者:2016年1月至2020年12月期间注册的脑瘫儿童(n=807),随访数据收集于2022年10月至2023年3月。干预措施:不适用。主要结局指标:主要结局指标为6岁前独立行走。结果:807名参与者中,561名(69.5%)实现了独立行走。单因素Cox回归确定了几个预测因素,包括新生儿窒息、胆红素脑病、2岁前大运动功能分类系统(GMFCS)水平、独立坐位年龄、CP类型、MRI分类、GMFM-88评分、癫痫、智力残疾、早期早产和极低出生体重(p)。机器学习模型准确地预测了CP儿童的独立行走能力,尽管校准分析表明5 ~ 6岁儿童可能被高估。所提出的nomogram为临床医生提供了一种个性化预后的可解释性工具。虽然内部验证显示了出色的性能,但未来在多中心队列中的外部验证将是确认可推广性的关键。临床试验注册号:不适用。
{"title":"Development and Validation of a Prognostic Model for Independent Walking in Children With Cerebral Palsy Based on Machine Learning","authors":"Wang Yiwen MD,&nbsp;Yang Yonghui MD","doi":"10.1016/j.apmr.2025.05.006","DOIUrl":"10.1016/j.apmr.2025.05.006","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and validate machine learning-based models for predicting independent walking ability in children with cerebral palsy (CP).</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>Data were collected from a national CP registry platform and follow-up assessments were conducted through telephone interviews.</div></div><div><h3>Participants</h3><div>Children with CP (n=807) registered between January 2016 and December 2020, with follow-up data collected from October 2022 to March 2023.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcome was independently walking before the age of 6 years.</div></div><div><h3>Results</h3><div>Among the 807 participants, 561 (69.5%) achieved independent walking. Univariate Cox regression identified several predictive factors, including neonatal asphyxia, bilirubin encephalopathy, Gross Motor Function Classification System level before age of 2 years, age of independent sitting, type of CP, magnetic resonance imaging classification, Gross Motor Function Measure-88 scores, epilepsy, intellectual disability, early preterm birth, and very low birth weight (<em>P</em>&lt;.05). Machine learning models demonstrated excellent predictive performance, with logistic regression achieving the highest area under the curve (AUC=0.947), followed by XGBoost (AUC=0.946) and multilayer perceptron (AUC=0.945). Cox proportional hazard models identified key predictors for the timing of independent walking, with a nomogram constructed for clinical application. Internal validation confirmed model reliability, although calibration curves indicated potential overestimation for ages 5-6 years.</div></div><div><h3>Conclusions</h3><div>Machine learning models accurately predict independent walking ability in children with CP, although calibration analyses indicated potential overestimation for children aged 5-6 years. The proposed nomogram provides clinicians with an interpretable tool for personalized prognosis. Although internal validation demonstrated excellent performance, future external validation in multicenter cohorts will be critical to confirm generalizability.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 12","pages":"Pages 1850-1858"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity and Reliability of Interview and Online Self-Report Versions of Motor and Sensory Components of a Neurological Exam for Classifying Spinal Cord Injury (One-SCI) 脊髓损伤分类神经系统检查中运动和感觉成分的访谈和在线自述版本的效度和信度。
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.05.016
Thomas N. Bryce MD , Laiba Afzal MS , Stephen P. Burns MD , Marcel P. Dijkers PhD , Steven Kirshblum MD , Ralph J. Marino MD , Jayme O’Connor BS , Arianny Ramirez BA , Brittany Snider DO , Lisa Spielman PhD , Chung-Ying Tsai PhD

Objective

To examine the feasibility, validity, and reliability of the Online Neurological Exam for Spinal Cord Injury (One-SCI), a patient-reported outcome measure of the motor and sensory components needed for classifying spinal cord injury (SCI) according to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI).

Design

Repeat administration (1wk interval) of either an online self-administered or an interviewer-administered survey (both supported by extensive computer-provided illustrations and animations) followed by an in-person ISNCSCI examination after an additional week.

Setting

Academic free standing rehabilitation center and medical center.

Participants

A total of 67 individuals (N=67) with chronic SCI with complete or incomplete injuries representing 6 groups based upon neurologic level of injury (C1-4, C5-6, C7-T1, T2-T6, T7-T12, and L1-S5) who were English-speaking and aged ≥18 years.

Interventions

Not applicable.

Main Outcome Measures

ISNCSCI neurologic levels and American Spinal Injury Association Impairment Scale (AIS) grade.

Results

Overall test–retest agreement was substantial, with kappas ranging from 0.69 to 0.84 for all the neurologic levels and AIS grades. Overall agreement between the neurologic levels and AIS grades derived from the first administration of One-SCI (participant survey responses) and the ISNCSCI examinations was moderate to substantial, with kappas ranging from 0.55 to 0.71. The median time needed to complete the interview and online versions of One-SCI the first time was 51 minutes.

Conclusions

Findings generally support the reliability and validity of both interview and online versions of One-SCI. One-SCI does take nearly 1 hour to complete, which possibly will limit its widespread use. The results should be replicated in larger samples.
目的:检验在线脊髓损伤神经系统检查(One-SCI)的可行性、有效性和可靠性,这是一种根据国际脊髓损伤神经学分类标准(ISNCSCI)对脊髓损伤(SCI)分类所需的运动和感觉成分的患者报告结果测量。重复管理(间隔一周)在线自我管理或访谈者管理的调查(两者都有大量的计算机提供的插图和动画支持),然后在额外的一周后进行面对面的ISNCSCI检查。67例慢性SCI完全性或不完全性损伤患者,根据神经损伤水平分为6组(C1-4、C5-6、C7-T1、T2-T6、T7-T12和L1-S5),年龄在18岁或以上。干预措施:不适用主要结局测量:ISNCSCI神经水平和美国脊髓损伤协会损伤量表(AIS)分级。所有神经学水平和AIS等级的kappas均在0.69至0.84之间,总体测试-重测试一致。从首次使用One-SCI(参与者调查反应)和ISNCSCI检查得出的神经学水平和AIS等级之间的总体一致性是中等到实质性的,kappas范围为0.55至0.71。第一次完成访谈和在线版One-SCI的平均时间为51分钟。结论:调查结果总体上支持访谈版和网络版的信度和效度。一个sci需要将近一个小时才能完成,这可能会限制它的广泛使用。结果应该在更大的样本中得到重复。
{"title":"Validity and Reliability of Interview and Online Self-Report Versions of Motor and Sensory Components of a Neurological Exam for Classifying Spinal Cord Injury (One-SCI)","authors":"Thomas N. Bryce MD ,&nbsp;Laiba Afzal MS ,&nbsp;Stephen P. Burns MD ,&nbsp;Marcel P. Dijkers PhD ,&nbsp;Steven Kirshblum MD ,&nbsp;Ralph J. Marino MD ,&nbsp;Jayme O’Connor BS ,&nbsp;Arianny Ramirez BA ,&nbsp;Brittany Snider DO ,&nbsp;Lisa Spielman PhD ,&nbsp;Chung-Ying Tsai PhD","doi":"10.1016/j.apmr.2025.05.016","DOIUrl":"10.1016/j.apmr.2025.05.016","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the feasibility, validity, and reliability of the Online Neurological Exam for Spinal Cord Injury (One-SCI), a patient-reported outcome measure of the motor and sensory components needed for classifying spinal cord injury (SCI) according to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI).</div></div><div><h3>Design</h3><div>Repeat administration (1wk interval) of either an online self-administered or an interviewer-administered survey (both supported by extensive computer-provided illustrations and animations) followed by an in-person ISNCSCI examination after an additional week.</div></div><div><h3>Setting</h3><div>Academic free standing rehabilitation center and medical center.</div></div><div><h3>Participants</h3><div>A total of 67 individuals (N=67) with chronic SCI with complete or incomplete injuries representing 6 groups based upon neurologic level of injury (C1-4, C5-6, C7-T1, T2-T6, T7-T12, and L1-S5) who were English-speaking and aged ≥18 years.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>ISNCSCI neurologic levels and American Spinal Injury Association Impairment Scale (AIS) grade.</div></div><div><h3>Results</h3><div>Overall test–retest agreement was substantial, with kappas ranging from 0.69 to 0.84 for all the neurologic levels and AIS grades. Overall agreement between the neurologic levels and AIS grades derived from the first administration of One-SCI (participant survey responses) and the ISNCSCI examinations was moderate to substantial, with kappas ranging from 0.55 to 0.71. The median time needed to complete the interview and online versions of One-SCI the first time was 51 minutes.</div></div><div><h3>Conclusions</h3><div>Findings generally support the reliability and validity of both interview and online versions of One-SCI. One-SCI does take nearly 1 hour to complete, which possibly will limit its widespread use. The results should be replicated in larger samples.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 12","pages":"Pages 1821-1828"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Therapeutic Exercises Versus General Conservative Modalities and Brace on the Progression of Adolescent Idiopathic Scoliosis: Systematic Review and Meta-analysis 治疗性运动与一般保守模式和支具对青少年特发性脊柱侧凸进展的影响:系统回顾和荟萃分析。
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.06.021
Rodrigo Mantelatto Andrade MS , Ana Paula Ribeiro PhD , Milene Eloise Callegari Ferreira MS , Larissa Calvo Piras MS , Maria de Lourddes de Moura Partika MS , Nelson Carvas Junior MS , Henry Dan Kiyomoto MS , Silvia Maria Amado João PhD

Objective

To compare the effects of therapeutic exercises in preventing Cobb angle progression in adolescent idiopathic scoliosis (AIS) compared with other conservative treatments.

Data Sources

Systematic searches were conducted in MEDLINE via PubMed, Embase, centralized database (CENTRAL), Physiotherapy Evidence Database (PEDro), and cumulative index to nursing and allied health literature up to December 14, 2023, and registered in PROSPERO (CRD42020156639).

Study Selection

Randomized controlled trials involving adolescents aged 10-18 years with AIS and a Cobb angle >10° were included.

Data Extraction

Two reviewers independently extracted study data, assessed the risk of bias using the PEDro scale, and the certainty of evidence—using the Grading of Recommendations, Assessment, Development and Evaluation approach.

Data Synthesis

Nineteen studies involving 832 participants met our selection criteria. The PEDro scale score ranged from 3 to 8 points (0-10). The results on Cobb angle progression showed no significant difference in Cobb angle reduction between therapeutic exercises and minimal intervention in the short term (mean difference [MD]=−1.33; 95% confidence interval [CI], −4.87 to 2.22). The specific therapeutic exercises showed greater Cobb angle reduction compared with general exercises in the short term (MD=−2.57; 95% CI, −4.56 to −0.59) and long term (MD=−6.00; 95% CI, −6.88 to −5.12). No significant difference was observed between therapeutic exercise and brace use in the short term (MD=0.20; 95% CI, −1.74 to 2.14); however, bracing was more effective in the long term (MD=2.66; 95% CI, 0.18-5.14). Therapeutic exercises with bracing significantly reduced Cobb angle in the short term compared with bracing alone (MD=2.25; 95% CI, −3.86 to −0.63).

Conclusions

This systematic review and meta-analysis suggest that therapeutic exercises can be effective in preventing Cobb angle progression in AIS. Specifically, targeted therapeutic exercises led to a greater reduction in Cobb angle compared with general exercises both in the short and long term. Although no significant difference was found between therapeutic exercises and minimal intervention in the short term, combining therapeutic exercises with bracing demonstrated a significant short term advantage over bracing alone. In the long term, bracing was found to be more effective than therapeutic exercises in preventing Cobb angle progression. Given the varied outcomes across different interventions and time frames, further high-quality trials are needed to establish optimal treatment protocols for managing AIS.
目的:比较治疗性运动在预防青少年特发性脊柱侧凸(AIS)的Cobb角进展方面与其他保守治疗的效果。检索平台:截至2023年12月14日,通过PubMed, Embase, CENTRAL, PEDro和CINAHL在MEDLINE中进行系统检索,并在PROSPERO中注册(CRD42020156639)。研究选择:纳入10 - 18岁患有AIS且Cobb角大于10度的青少年的随机对照试验。数据提取:两位审稿人独立提取研究数据,使用PEDro量表评估偏倚风险,使用GRADE方法评估证据的确定性。数据综合:19项涉及832名参与者的研究符合我们的选择标准。佩德罗量表得分范围从3到8分(0-10)。Cobb角进展的结果显示,治疗性运动与最小干预在短期内Cobb角减小方面无显著差异(MD= -1.33;95% CI -4.87至2.22)。与一般运动相比,特殊治疗运动在短期内显示出更大的Cobb角降低(MD = -2.57;95% CI -4.56至-0.59)和长期(MD = -6.00;95% CI -6.88至-5.12)。治疗性运动与支具使用在短期内无显著差异(MD = 0.20;95% CI: -1.74至2.14);然而,支具在长期内更有效(MD = 2.66;95% CI: 0.18 ~ 5.14)。治疗性运动加支具较单独支具在短期内显著降低Cobb角(MD = 2.25;95% CI: -3.86 ~ -0.63)。结论:本系统综述和荟萃分析表明,治疗性锻炼可有效预防青少年特发性脊柱侧凸(AIS)的Cobb角进展。具体来说,与一般运动相比,有针对性的治疗性运动在短期和长期内都能更大程度地降低科布角。虽然在短期内治疗性运动和最小干预之间没有发现显著差异,但将治疗性运动与支具结合显示出明显优于单独支具的短期优势。长期来看,支具在预防Cobb角进展方面比治疗性运动更有效。考虑到不同干预措施和时间框架的不同结果,需要进一步的高质量试验来建立管理AIS的最佳治疗方案。
{"title":"Impact of Therapeutic Exercises Versus General Conservative Modalities and Brace on the Progression of Adolescent Idiopathic Scoliosis: Systematic Review and Meta-analysis","authors":"Rodrigo Mantelatto Andrade MS ,&nbsp;Ana Paula Ribeiro PhD ,&nbsp;Milene Eloise Callegari Ferreira MS ,&nbsp;Larissa Calvo Piras MS ,&nbsp;Maria de Lourddes de Moura Partika MS ,&nbsp;Nelson Carvas Junior MS ,&nbsp;Henry Dan Kiyomoto MS ,&nbsp;Silvia Maria Amado João PhD","doi":"10.1016/j.apmr.2025.06.021","DOIUrl":"10.1016/j.apmr.2025.06.021","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the effects of therapeutic exercises in preventing Cobb angle progression in adolescent idiopathic scoliosis (AIS) compared with other conservative treatments.</div></div><div><h3>Data Sources</h3><div>Systematic searches were conducted in MEDLINE via PubMed, Embase, centralized database (CENTRAL), Physiotherapy Evidence Database (PEDro), and cumulative index to nursing and allied health literature up to December 14, 2023, and registered in PROSPERO (CRD42020156639).</div></div><div><h3>Study Selection</h3><div>Randomized controlled trials involving adolescents aged 10-18 years with AIS and a Cobb angle &gt;10° were included.</div></div><div><h3>Data Extraction</h3><div>Two reviewers independently extracted study data, assessed the risk of bias using the PEDro scale, and the certainty of evidence—using the Grading of Recommendations, Assessment, Development and Evaluation approach.</div></div><div><h3>Data Synthesis</h3><div>Nineteen studies involving 832 participants met our selection criteria. The PEDro scale score ranged from 3 to 8 points (0-10). The results on Cobb angle progression showed no significant difference in Cobb angle reduction between therapeutic exercises and minimal intervention in the short term (mean difference [MD]=−1.33; 95% confidence interval [CI], −4.87 to 2.22). The specific therapeutic exercises showed greater Cobb angle reduction compared with general exercises in the short term (MD=−2.57; 95% CI, −4.56 to −0.59) and long term (MD=−6.00; 95% CI, −6.88 to −5.12). No significant difference was observed between therapeutic exercise and brace use in the short term (MD=0.20; 95% CI, −1.74 to 2.14); however, bracing was more effective in the long term (MD=2.66; 95% CI, 0.18-5.14). Therapeutic exercises with bracing significantly reduced Cobb angle in the short term compared with bracing alone (MD=2.25; 95% CI, −3.86 to −0.63).</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis suggest that therapeutic exercises can be effective in preventing Cobb angle progression in AIS. Specifically, targeted therapeutic exercises led to a greater reduction in Cobb angle compared with general exercises both in the short and long term. Although no significant difference was found between therapeutic exercises and minimal intervention in the short term, combining therapeutic exercises with bracing demonstrated a significant short term advantage over bracing alone. In the long term, bracing was found to be more effective than therapeutic exercises in preventing Cobb angle progression. Given the varied outcomes across different interventions and time frames, further high-quality trials are needed to establish optimal treatment protocols for managing AIS.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 12","pages":"Pages 1874-1885"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Interpretability of Patient-Reported Outcomes Measurement Information System (PROMIS) and Related Measures in Rehabilitation Populations: A Systematic Review of Clinical and Research Applications. 增强康复人群中患者报告结果测量信息系统(PROMIS)和相关措施的可解释性:临床和研究应用的系统综述。
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.11.017
Rehab Alhasani, Rebecca Ataman, Zanib Nafees, Anita Luong, Line Auneau-Enjalber, Adria Quigley, Henry Ukachukwu Michael, Sara Ahmed

Objective: To evaluate and synthesize interpretability metrics, including minimal important change (MIC), minimal important difference (MID), and minimal detectable change (MDC), across Patient-Reported Outcomes Measurement Information System (PROMIS) and related systems (Quality of Life in Neurological Disorders [Neuro-QoL], Quality of Life in Traumatic Brain Injury [TBI-QoL], Quality of Life in Spinal Cord Injury [SCI-QoL]) in rehabilitation populations.

Data sources: Comprehensive searches of electronic databases (MEDLINE, EMBASE, PsycINFO, HaPI, CINAHL, Cochrane Library, Web of Science) and clinical trial registries (ISRCTN Registry, ClinicalTrials.gov) were conducted from inception through March 23, 2024, in consultation with an information specialist.

Study selection: Eligible studies assessed interpretability metrics in rehabilitation populations using PROMIS, Neuro-QoL, TBI-QoL, or SCI-QoL. Studies of pediatric or nonrehabilitation populations, abstracts, posters, or consensus statements were excluded. A total of 202 studies met inclusion criteria.

Data extraction: Two independent reviewers extracted study characteristics, interpretability metrics, and analytical methods following COnsensus-based Standards for the Selection of Health Measurement Instruments guidelines.

Data synthesis: MIC, MID, and MDC values varied widely across populations and domains. PROMIS mental health domains (eg, depression, anxiety, fatigue) demonstrated relatively consistent estimates, whereas physical function domains were more variable, particularly in chronic and geriatric groups. PROMIS Computer Adaptive Testing measures showed fewer floor and ceiling effects than short forms, indicating enhanced sensitivity to change. Limited data were available for SCI-QoL and TBI-QoL.

Conclusions: Standardizing interpretability metrics and expanding research on SCI-QoL and TBI-QoL are critical to improving the clinical utility of these measures in rehabilitation. Future work should incorporate response-shift considerations and establish population-specific cut-points to support patient-centered care and evidence-based practice.

目的:评价和综合康复人群中PROMIS及相关系统(neuroqol、TBI-QoL、SCI-QoL)的可解释性指标,包括最小重要变化(MIC)、最小重要差异(MID)和最小可检测变化(MDC)。数据来源:综合检索电子数据库(MEDLINE, EMBASE, PsycINFO, HaPI, CINAHL, Cochrane Library, Web of Science)和临床试验注册(ISRCTN Registry, ClinicalTrials.gov),从成立到2024年3月23日,与信息专家协商。研究选择:符合条件的研究使用PROMIS、neuroqol、TBI-QoL或SCI-QoL评估康复人群的可解释性指标。排除了儿童或非康复人群的研究、摘要、海报或共识声明。共有202项研究符合纳入标准。数据提取:两名独立审稿人根据基于共识的健康测量工具选择标准(COSMIN)指南提取研究特征、可解释性指标和分析方法。数据综合:MIC、MID和MDC值在人群和领域之间差异很大。PROMIS的心理健康领域(如抑郁、焦虑、疲劳)显示出相对一致的估计,而身体功能领域则更加多变,特别是在慢性和老年群体中。PROMIS计算机自适应测试(CAT)的测量结果显示,与短格式相比,下限和上限效应更少,表明对变化的敏感性增强。SCI-QoL和TBI-QoL资料有限。结论:标准化可解释性指标和扩大SCI-QoL和TBI-QoL的研究对提高这些指标在康复中的临床应用至关重要。未来的工作应纳入响应转移的考虑,并建立特定人群的切入点,以支持以患者为中心的护理和循证实践。
{"title":"Enhancing Interpretability of Patient-Reported Outcomes Measurement Information System (PROMIS) and Related Measures in Rehabilitation Populations: A Systematic Review of Clinical and Research Applications.","authors":"Rehab Alhasani, Rebecca Ataman, Zanib Nafees, Anita Luong, Line Auneau-Enjalber, Adria Quigley, Henry Ukachukwu Michael, Sara Ahmed","doi":"10.1016/j.apmr.2025.11.017","DOIUrl":"10.1016/j.apmr.2025.11.017","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and synthesize interpretability metrics, including minimal important change (MIC), minimal important difference (MID), and minimal detectable change (MDC), across Patient-Reported Outcomes Measurement Information System (PROMIS) and related systems (Quality of Life in Neurological Disorders [Neuro-QoL], Quality of Life in Traumatic Brain Injury [TBI-QoL], Quality of Life in Spinal Cord Injury [SCI-QoL]) in rehabilitation populations.</p><p><strong>Data sources: </strong>Comprehensive searches of electronic databases (MEDLINE, EMBASE, PsycINFO, HaPI, CINAHL, Cochrane Library, Web of Science) and clinical trial registries (ISRCTN Registry, ClinicalTrials.gov) were conducted from inception through March 23, 2024, in consultation with an information specialist.</p><p><strong>Study selection: </strong>Eligible studies assessed interpretability metrics in rehabilitation populations using PROMIS, Neuro-QoL, TBI-QoL, or SCI-QoL. Studies of pediatric or nonrehabilitation populations, abstracts, posters, or consensus statements were excluded. A total of 202 studies met inclusion criteria.</p><p><strong>Data extraction: </strong>Two independent reviewers extracted study characteristics, interpretability metrics, and analytical methods following COnsensus-based Standards for the Selection of Health Measurement Instruments guidelines.</p><p><strong>Data synthesis: </strong>MIC, MID, and MDC values varied widely across populations and domains. PROMIS mental health domains (eg, depression, anxiety, fatigue) demonstrated relatively consistent estimates, whereas physical function domains were more variable, particularly in chronic and geriatric groups. PROMIS Computer Adaptive Testing measures showed fewer floor and ceiling effects than short forms, indicating enhanced sensitivity to change. Limited data were available for SCI-QoL and TBI-QoL.</p><p><strong>Conclusions: </strong>Standardizing interpretability metrics and expanding research on SCI-QoL and TBI-QoL are critical to improving the clinical utility of these measures in rehabilitation. Future work should incorporate response-shift considerations and establish population-specific cut-points to support patient-centered care and evidence-based practice.</p>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Characterization of Hip Subgroups in Geriatric Chronic Low Back Pain 老年慢性腰痛髋部亚群的临床特征。
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.04.018
Jenifer M. Pugliese PT, DPT , Jaclyn Megan Sions PT, DPT, PhD , Patrick J. Knox PT, DPT, PhD , Ryan T. Pohlig PhD , Gregory E. Hicks PT, PhD

Objective

To investigate and compare the clinical profiles of 3 previously established hip-based subgroups of older adults with chronic low back pain (LBP) using data from multiple domains.

Design

Cross-sectional analysis of baseline cohort study data.

Setting

Clinical research laboratory.

Participants

Two hundred fifty (n=250) community dwelling older adults with chronic LBP.

Interventions

Not applicable.

Main Outcome Measures

Clinical profiles of the previously derived subgroups were established. Pain quality and dispersion were captured with the McGill Pain Questionnaire. Self-efficacy was measured using the Low Back Activity Confidence Scale. Catastrophic thoughts about LBP were captured with the Pain Catastrophizing Scale. Trunk mobility was measured with an inclinometer. Trunk muscle function was captured through standardized muscle endurance testing and ultrasound measures of muscle activity. One-way analysis of variance was used to analyze between-group differences.

Results

Each chronic LBP subgroup was named based on the level of hip strength and hip symptoms: weak and symptomatic, weak and nonsymptomatic, and strong and nonsymptomatic. The weak and symptomatic subgroup had distinctly worse levels of pain quality, dispersion, catastrophizing and self-efficacy, compared with the other 2 subgroups. In contrast, the strong and nonsymptomatic subgroup, as compared with the other subgroups, had greater thoracolumbar flexion, greater trunk muscle endurance and better psychological profiles.

Conclusions

The unique clinical profile of each subgroup underscores how important it is to consider the heterogeneous nature of chronic LBP in the geriatric population when developing treatment approaches. The clinical characterization of these subgroups across multiple rehabilitation-focused domains may optimize the development of tailored interventions for each subgroup.
目的:利用来自多个领域的数据,调查和比较三个先前建立的基于髋关节的老年慢性腰痛(LBP)亚组的临床概况。设计:基线队列研究数据的横断面分析。单位:临床研究实验室。参与者:250名社区居住的慢性下腰痛老年人。干预措施:不适用。主要结果测量:建立了先前衍生亚组的临床概况。用McGill疼痛问卷记录疼痛质量和分散度。自我效能用腰背活动信心量表测量。关于腰痛的灾难性想法用疼痛灾难性量表来记录。用倾斜仪测量躯干活动度。通过标准化肌肉耐力测试和超声测量肌肉活动来捕获躯干肌肉功能。组间差异分析采用单因素方差分析。结果:每个慢性腰痛亚组根据髋关节力量和髋关节症状的水平命名:弱/有症状(WS)、弱/无症状(WNS)和强/无症状(SNS)。与其他两个亚组相比,WS亚组的疼痛质量、离散度、灾难化和自我效能感水平明显较差。相比之下,SNS亚组与其他亚组相比,有更大的胸腰椎屈曲,更大的躯干肌肉耐力和更好的心理特征。结论:每个亚组的独特临床特征强调了在制定治疗方法时考虑老年人群慢性腰痛异质性的重要性。这些亚组跨越多个康复重点领域的临床特征可以优化每个亚组量身定制的干预措施的发展。
{"title":"Clinical Characterization of Hip Subgroups in Geriatric Chronic Low Back Pain","authors":"Jenifer M. Pugliese PT, DPT ,&nbsp;Jaclyn Megan Sions PT, DPT, PhD ,&nbsp;Patrick J. Knox PT, DPT, PhD ,&nbsp;Ryan T. Pohlig PhD ,&nbsp;Gregory E. Hicks PT, PhD","doi":"10.1016/j.apmr.2025.04.018","DOIUrl":"10.1016/j.apmr.2025.04.018","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate and compare the clinical profiles of 3 previously established hip-based subgroups of older adults with chronic low back pain (LBP) using data from multiple domains.</div></div><div><h3>Design</h3><div>Cross-sectional analysis of baseline cohort study data.</div></div><div><h3>Setting</h3><div>Clinical research laboratory.</div></div><div><h3>Participants</h3><div>Two hundred fifty (n=250) community dwelling older adults with chronic LBP.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>Clinical profiles of the previously derived subgroups were established. Pain quality and dispersion were captured with the McGill Pain Questionnaire. Self-efficacy was measured using the Low Back Activity Confidence Scale. Catastrophic thoughts about LBP were captured with the Pain Catastrophizing Scale. Trunk mobility was measured with an inclinometer. Trunk muscle function was captured through standardized muscle endurance testing and ultrasound measures of muscle activity. One-way analysis of variance was used to analyze between-group differences.</div></div><div><h3>Results</h3><div>Each chronic LBP subgroup was named based on the level of hip strength and hip symptoms: weak and symptomatic, weak and nonsymptomatic, and strong and nonsymptomatic. The weak and symptomatic subgroup had distinctly worse levels of pain quality, dispersion, catastrophizing and self-efficacy, compared with the other 2 subgroups. In contrast, the strong and nonsymptomatic subgroup, as compared with the other subgroups, had greater thoracolumbar flexion, greater trunk muscle endurance and better psychological profiles.</div></div><div><h3>Conclusions</h3><div>The unique clinical profile of each subgroup underscores how important it is to consider the heterogeneous nature of chronic LBP in the geriatric population when developing treatment approaches. The clinical characterization of these subgroups across multiple rehabilitation-focused domains may optimize the development of tailored interventions for each subgroup.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 12","pages":"Pages 1859-1865"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness, Feasibility, Acceptability, and Safety of Digital Interventions in Post-Stroke Rehabilitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials 数字干预在脑卒中后康复中的有效性、可行性、可接受性和安全性:随机对照试验的系统回顾和荟萃分析。
IF 3.7 2区 医学 Q1 REHABILITATION Pub Date : 2025-12-01 DOI: 10.1016/j.apmr.2025.07.004
Shuangyue Liu MD , Min Li MD , Jilin Ding MD , Qipei Ji MD , Yanning Niu MD , Xiao Yang MD , Shuangchun Ai PhD , Siyuan Li PhD

Objective

To assess the effects of digital interventions on cognition, emotion, and activities of daily living (ADL) in stroke survivors, alongside evaluating feasibility, acceptability, and safety metrics.

Data Sources

We systematically searched 11 English databases for eligible studies published between 2000 and May 2025.

Study Selection

Randomized control trials that focused on poststroke digital therapeutics were included. Experimental groups received digital interventions, while control groups underwent standard therapies or placebo. The outcomes included cognition, emotion, ADL, feasibility, acceptability, and safety.

Data Extraction

Two researchers independently extracted key data from eligible studies. Risk and methodology were assessed using the Cochrane Risk of Bias v2.0 and the PEDro scale. The meta-analysis was conducted using CMA v3.7, following the PRISMA 2020 guidelines.

Data Synthesis

Sixty-three studies (3297 participants) demonstrated significant improvements in overall cognition (g=0.46; 95% CI, 0.24-0.67; P<.001), ADL (g=0.38; 95% CI, 0.19-0.57; P<.001), and specific domains (global cognition, language, visuospatial; all P<.05). Exergaming and computer cognitive training significantly improved overall cognition and memory compared to other digital interventions. Medical sites-based interventions significantly enhanced overall/global cognition versus home-based protocols. Shorter sessions (≤30min) demonstrated superior efficacy in overall cognition to longer durations. Robot-assisted and computer cognitive training maximized ADL gains. Despite significant between-subgroup heterogeneity in emotion outcomes, no within-subgroup efficacy emerged for any digital interventions. Results showed varied recruitment (4.97%-100%) and retention (mostly >75%) across digital interventions. Adherence and attendance were generally high, while safety profiles were mostly favorable with mild adverse events like fatigue or dizziness in some cases.

Conclusions

Digital interventions significantly enhance cognition when delivered via clinic-based exergaming or computer cognitive training (≤30min/session), while maximizing ADL improvements through robot-assisted or computer cognitive training in stroke patients. Robust feasibility, acceptability, and favorable safety supports clinical integration.
目的:评估数字干预对脑卒中幸存者认知、情绪和日常生活活动(ADL)的影响,同时评估可行性、可接受性和安全性指标。数据来源:我们系统地检索了11个英文数据库,检索了2000年至2025年5月间发表的符合条件的研究。研究选择:纳入了关注脑卒中后数字治疗的随机对照试验。实验组接受数字干预,而对照组则接受标准治疗或安慰剂。结果包括认知、情绪、ADL、可行性、可接受性和安全性。数据提取:两位研究者独立地从符合条件的研究中提取关键数据。采用Cochrane风险偏倚v2.0和PEDro量表评估风险和方法。meta分析使用CMA v3.7进行,遵循PRISMA 2020指南。数据综合:63项研究(3297名参与者)显示,总体认知(g = 0.46,95% CI 0.24-0.67, p < 0.001)、ADL (g = 0.38,95% CI 0.19-0.57, p < 0.001)和特定领域(全球认知、语言、视觉空间;p < 0.05)。与其他数字干预相比,游戏和计算机认知训练显著改善了整体认知和记忆。与基于家庭的方案相比,基于医疗站点的干预措施显著增强了整体/全局认知。较短的疗程(≤30分钟)在整体认知方面优于较长的疗程。机器人辅助和计算机认知训练使ADL收益最大化。尽管情绪结果在亚组之间存在显著的异质性,但没有出现任何数字干预的亚组内疗效。结果显示,在数字干预措施中,招聘人数(4.97-100%)和保留人数(大部分为75%)各不相同。依从性和出勤率普遍较高,而安全性主要是有利的,在某些情况下有轻微的不良事件,如疲劳或头晕。结论:通过临床练习或计算机认知训练(≤30分钟/次)提供数字干预可显著增强认知能力,而通过机器人辅助或计算机认知训练可最大限度地改善脑卒中患者的ADL。强大的可行性,可接受性和良好的安全性支持临床整合。
{"title":"Effectiveness, Feasibility, Acceptability, and Safety of Digital Interventions in Post-Stroke Rehabilitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials","authors":"Shuangyue Liu MD ,&nbsp;Min Li MD ,&nbsp;Jilin Ding MD ,&nbsp;Qipei Ji MD ,&nbsp;Yanning Niu MD ,&nbsp;Xiao Yang MD ,&nbsp;Shuangchun Ai PhD ,&nbsp;Siyuan Li PhD","doi":"10.1016/j.apmr.2025.07.004","DOIUrl":"10.1016/j.apmr.2025.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effects of digital interventions on cognition, emotion, and activities of daily living (ADL) in stroke survivors, alongside evaluating feasibility, acceptability, and safety metrics.</div></div><div><h3>Data Sources</h3><div>We systematically searched 11 English databases for eligible studies published between 2000 and May 2025.</div></div><div><h3>Study Selection</h3><div>Randomized control trials that focused on poststroke digital therapeutics were included. Experimental groups received digital interventions, while control groups underwent standard therapies or placebo. The outcomes included cognition, emotion, ADL, feasibility, acceptability, and safety.</div></div><div><h3>Data Extraction</h3><div>Two researchers independently extracted key data from eligible studies. Risk and methodology were assessed using the Cochrane Risk of Bias v2.0 and the PEDro scale. The meta-analysis was conducted using CMA v3.7, following the PRISMA 2020 guidelines.</div></div><div><h3>Data Synthesis</h3><div>Sixty-three studies (3297 participants) demonstrated significant improvements in overall cognition (<em>g</em>=0.46; 95% CI, 0.24-0.67; <em>P</em>&lt;.001), ADL (<em>g</em>=0.38; 95% CI, 0.19-0.57; <em>P</em>&lt;.001), and specific domains (global cognition, language, visuospatial; all <em>P</em>&lt;.05). Exergaming and computer cognitive training significantly improved overall cognition and memory compared to other digital interventions. Medical sites-based interventions significantly enhanced overall/global cognition versus home-based protocols. Shorter sessions (≤30min) demonstrated superior efficacy in overall cognition to longer durations. Robot-assisted and computer cognitive training maximized ADL gains. Despite significant between-subgroup heterogeneity in emotion outcomes, no within-subgroup efficacy emerged for any digital interventions. Results showed varied recruitment (4.97%-100%) and retention (mostly &gt;75%) across digital interventions. Adherence and attendance were generally high, while safety profiles were mostly favorable with mild adverse events like fatigue or dizziness in some cases.</div></div><div><h3>Conclusions</h3><div>Digital interventions significantly enhance cognition when delivered via clinic-based exergaming or computer cognitive training (≤30min/session), while maximizing ADL improvements through robot-assisted or computer cognitive training in stroke patients. Robust feasibility, acceptability, and favorable safety supports clinical integration.</div></div>","PeriodicalId":8313,"journal":{"name":"Archives of physical medicine and rehabilitation","volume":"106 12","pages":"Pages 1912-1932"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Archives of physical medicine and rehabilitation
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