Pub Date : 2020-12-01DOI: 10.30476/ACRR.2020.87299.1057
A. Doğan, Ö. Özkan, S. Cimen
Dyspareunia is a general term used to describe painful sexual intercourse. It can occur due to a variety of reasons ranging from structural problems to psychological concerns. Dyspareunia frequently occurs due to pelvic inflammatory disease, endometriosis, absence of lubrication and previous trauma. Additionally, eczema, hidradenitis or other skin diseases of the vulva may cause pain with intercourse. Pilonidal sinus is a common skin disease presenting with hair-nests and sinus tracts occurring in deep skin folds such as the inter-gluteal sulcus. A 30-year-old dark haired Asian housewife, gravid 1 para 1 was seen at the general surgery outpatient clinic with complaints of foul smelling thick umbilical discharge and dyspareunia. Dyspareunia due to clitoral pilonidal sinus can successfully be cured with early diagnosis, appropriate antibiotics and wide surgical excision of the lesion. Delay in diagnosis and treatment is associated with development of complications such as abscess formation, prolongs time to definitive treatment and affects the prognosis of the disease. In cases of swelling at the mons pubis, vulvar pain and unexplained dyspareunia observed in menstrual aged women, clitoral pilonidal sinus should be kept in mind as a potential cause. Herein, we present a young woman with dyspareunia secondary to clitoral pilonidal sinus.
{"title":"Dyspareunia Secondary to a Clitoral Pilonidal Sinus: A Case Report and Literature Review","authors":"A. Doğan, Ö. Özkan, S. Cimen","doi":"10.30476/ACRR.2020.87299.1057","DOIUrl":"https://doi.org/10.30476/ACRR.2020.87299.1057","url":null,"abstract":"Dyspareunia is a general term used to describe painful sexual intercourse. It can occur due to a variety of reasons ranging from structural problems to psychological concerns. Dyspareunia frequently occurs due to pelvic inflammatory disease, endometriosis, absence of lubrication and previous trauma. Additionally, eczema, hidradenitis or other skin diseases of the vulva may cause pain with intercourse. Pilonidal sinus is a common skin disease presenting with hair-nests and sinus tracts occurring in deep skin folds such as the inter-gluteal sulcus. A 30-year-old dark haired Asian housewife, gravid 1 para 1 was seen at the general surgery outpatient clinic with complaints of foul smelling thick umbilical discharge and dyspareunia. Dyspareunia due to clitoral pilonidal sinus can successfully be cured with early diagnosis, appropriate antibiotics and wide surgical excision of the lesion. Delay in diagnosis and treatment is associated with development of complications such as abscess formation, prolongs time to definitive treatment and affects the prognosis of the disease. In cases of swelling at the mons pubis, vulvar pain and unexplained dyspareunia observed in menstrual aged women, clitoral pilonidal sinus should be kept in mind as a potential cause. Herein, we present a young woman with dyspareunia secondary to clitoral pilonidal sinus.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"70 1","pages":"200-205"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74130927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.30476/ACRR.2021.88459.1066
L. Mohajerzadeh, Ashkan Soltani, A. Zakeri, Ahmad Khaleghnejad Tabari, M. Rouzrokh, J. Ghoroubi, M. Sarafi, N. Dara, Farnoosh Rahimi, Sayeh Hatefi
Background: A large number of patients who underwent pull-through surgery due to Hirschsprung's disease (HD) were not followed up properly and they suffered from many complications such as fecal soiling, constipation, and etc. Although some of these complications may relief over time, it is rational to consider an evaluative protocol to identify anatomical or pathological complications in these patients. Objective: The aim of the present study is to evaluate and introduce these catastrophic complications. Method: In this historical cohort study, 193 patients with HD who had undergone pull- through surgery between 2006 to 2013 were considered. All files and questionnaires were used to collect patients' information and patients were physically examined individually. The mean duration of the follow-up was 96.4±17.2 months ranging from 60 to 144 months The follow-up performed for all patients via the outpatient clinics or by telephone. All statistical information was analyzed by SPSS software version 17. Results: Results: At first presentation, intestinal obstruction was more frequent than constipation. The most common involved segment was in rectosigmoid. The most common early postoperative complication was stricture in anal canal and the most common late complications were constipation and focal soiling. Conclusion: Although surgical advancements, a large number of patients underwent surgical procedures due to HD experience long term complications. Surgical treatment of HD generally present with high-quality outcome and the majority of children survive in satisfactory situation for long time but occasionally pediatric surgeons meet head-on catastrophic complication in these patients that require extended team work to be resolved
{"title":"Long-term Follow-up of Patients with Hirschsprung Disease: Unusual Late Complications After Pull-through","authors":"L. Mohajerzadeh, Ashkan Soltani, A. Zakeri, Ahmad Khaleghnejad Tabari, M. Rouzrokh, J. Ghoroubi, M. Sarafi, N. Dara, Farnoosh Rahimi, Sayeh Hatefi","doi":"10.30476/ACRR.2021.88459.1066","DOIUrl":"https://doi.org/10.30476/ACRR.2021.88459.1066","url":null,"abstract":"Background: A large number of patients who underwent pull-through surgery due to Hirschsprung's disease (HD) were not followed up properly and they suffered from many complications such as fecal soiling, constipation, and etc. Although some of these complications may relief over time, it is rational to consider an evaluative protocol to identify anatomical or pathological complications in these patients. Objective: The aim of the present study is to evaluate and introduce these catastrophic complications. Method: In this historical cohort study, 193 patients with HD who had undergone pull- through surgery between 2006 to 2013 were considered. All files and questionnaires were used to collect patients' information and patients were physically examined individually. The mean duration of the follow-up was 96.4±17.2 months ranging from 60 to 144 months The follow-up performed for all patients via the outpatient clinics or by telephone. All statistical information was analyzed by SPSS software version 17. Results: Results: At first presentation, intestinal obstruction was more frequent than constipation. The most common involved segment was in rectosigmoid. The most common early postoperative complication was stricture in anal canal and the most common late complications were constipation and focal soiling. Conclusion: Although surgical advancements, a large number of patients underwent surgical procedures due to HD experience long term complications. Surgical treatment of HD generally present with high-quality outcome and the majority of children survive in satisfactory situation for long time but occasionally pediatric surgeons meet head-on catastrophic complication in these patients that require extended team work to be resolved","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"10 1","pages":"175-180"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75664314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.30476/ACRR.2020.87655.1061
F. Rivera, Yuliana Mendoza, H. Medina
Context: In recent decades there has been an increase in hereditary colorectal cancer cases in people under 50 years of age. Several studies revealed similar pathologies with both molecular and clinical variations about hereditary colorectal neoplasms. We subdivided those new pathologies derived from the two groups in which hereditary colorectal cancer is classified: polyposis syndromes and non polyposis syndromes. Evidence Acquisition: The scientific search was done up to July – October, 2020. The search was limited to predefined keywords. The inclusion criteria were articles relevant to the search criteria (keywords). After, Rivera F. and Mendoza Y. looked for the associated articles, removed duplicates, and selected relevant information for our review manuscript. We included 80 scientific articles that met the established criteria. Results: Syndromes were divided according to the presence of polyps or not and their histological type and the classification or subclassification. Also we explain the type of inheritance, the affected genes, the clinical manifestations, the mean age of presentation of the disease and the polyps histology in case the disease has it. So, in this article we facilitated the identification of each syndrome for the reader. Conclusions: Despite representing a low etiology of colorectal cancer, cases of hereditary colorectal cancer show an increased trend over the last years. The development of genetic research has led to the establishment, modification and redefinition of molecular and clinical criteria associated with this pathology. However, there is a small group of patients that don't have molecular or clinical criteria belonging to any classification. Also the limited access or high cost associated with molecular analysis complicates the study of these pathologies and therefore lead to insufficient diagnosis and general treatment. For these reasons, there are still new genetic branches on hereditary colorectal cancer to investigate and thus establish comprehensive treatments for patients.
{"title":"Hereditary colorectal cancer syndromes","authors":"F. Rivera, Yuliana Mendoza, H. Medina","doi":"10.30476/ACRR.2020.87655.1061","DOIUrl":"https://doi.org/10.30476/ACRR.2020.87655.1061","url":null,"abstract":"Context: In recent decades there has been an increase in hereditary colorectal cancer cases in people under 50 years of age. Several studies revealed similar pathologies with both molecular and clinical variations about hereditary colorectal neoplasms. We subdivided those new pathologies derived from the two groups in which hereditary colorectal cancer is classified: polyposis syndromes and non polyposis syndromes. Evidence Acquisition: The scientific search was done up to July – October, 2020. The search was limited to predefined keywords. The inclusion criteria were articles relevant to the search criteria (keywords). After, Rivera F. and Mendoza Y. looked for the associated articles, removed duplicates, and selected relevant information for our review manuscript. We included 80 scientific articles that met the established criteria. Results: Syndromes were divided according to the presence of polyps or not and their histological type and the classification or subclassification. Also we explain the type of inheritance, the affected genes, the clinical manifestations, the mean age of presentation of the disease and the polyps histology in case the disease has it. So, in this article we facilitated the identification of each syndrome for the reader. Conclusions: Despite representing a low etiology of colorectal cancer, cases of hereditary colorectal cancer show an increased trend over the last years. The development of genetic research has led to the establishment, modification and redefinition of molecular and clinical criteria associated with this pathology. However, there is a small group of patients that don't have molecular or clinical criteria belonging to any classification. Also the limited access or high cost associated with molecular analysis complicates the study of these pathologies and therefore lead to insufficient diagnosis and general treatment. For these reasons, there are still new genetic branches on hereditary colorectal cancer to investigate and thus establish comprehensive treatments for patients.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"98 1","pages":"157-169"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81112643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.30476/ACRR.2021.88432.1065
A. Nugroho, R. Saunar, Indah Jamtani, M. L. Syahbana, Syamsu Hudaya, A. Widarso, T. Poniman
Bowel endometriosis, defined as presence of endometrial tissue infiltrating the intestinal muscularis propria layer and beyond (3), has a sigmoid colon and rectal predilection. We collected 170 cases of endometriosis within the timeline, out of which DIE was diagnosed in 47 cases (27%). Deep Infiltrating Endometriosis (DIE) that effected the bowel, including those that only effected the perirectal fat and rectal serosa were 19 cases (40%); 11 cases (58%) had DIE infiltrating past the rectal serosa. A total of 8 cases (42%), with only perirectal fat and rectal serosa involvement were treated with either disc excision or shaving, were excluded from this study We described the clinical characteristics of 9 patients with rectal DIE that were treated with Segmental Resection along with primary gynecological resection. In summary, Segmental resection is safe and feasible, even with minimally invasive technique, to be incorporated in the comprehensive multidisciplinary management of bowel endometriosis. Further effort to expand its use is necessary to increase the scope of bowel endometriosis management across the country.
{"title":"Single Center Experience of a Safe and Feasible Segmental Resection of Rectosigmoid Endometriosis","authors":"A. Nugroho, R. Saunar, Indah Jamtani, M. L. Syahbana, Syamsu Hudaya, A. Widarso, T. Poniman","doi":"10.30476/ACRR.2021.88432.1065","DOIUrl":"https://doi.org/10.30476/ACRR.2021.88432.1065","url":null,"abstract":"Bowel endometriosis, defined as presence of endometrial tissue infiltrating the intestinal muscularis propria layer and beyond (3), has a sigmoid colon and rectal predilection. We collected 170 cases of endometriosis within the timeline, out of which DIE was diagnosed in 47 cases (27%). Deep Infiltrating Endometriosis (DIE) that effected the bowel, including those that only effected the perirectal fat and rectal serosa were 19 cases (40%); 11 cases (58%) had DIE infiltrating past the rectal serosa. A total of 8 cases (42%), with only perirectal fat and rectal serosa involvement were treated with either disc excision or shaving, were excluded from this study We described the clinical characteristics of 9 patients with rectal DIE that were treated with Segmental Resection along with primary gynecological resection. In summary, Segmental resection is safe and feasible, even with minimally invasive technique, to be incorporated in the comprehensive multidisciplinary management of bowel endometriosis. Further effort to expand its use is necessary to increase the scope of bowel endometriosis management across the country.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"15 1","pages":"187-191"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90309367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.30476/ACRR.2021.89007.1074
F. Mendoza-Moreno, E. Ovejero-Merino, J. Ocaña, Fernando Noguerales-Fraguas, Belén Matías-García, Ana Quiroga-Valcárcel, Alma Blázquez-Martín, A. Minaya‐Bravo, A. Silva-Mato, Á. Gutiérrez
Background: in recent years, colorectal cancer incidence has declined dramatically. Screening programs, based on endoscopic resection of polipoid precancerous lesions, are being fundamental in that desirable improvement. Material and methods: prospective observational study of a set of patients who had an endoscopic resection of colonic polipoid lesions from January-2007 to December-2012. We analized “polyps rate” by colonoscopy, number of patients, follow-up time, and “relationship with later cancer appearance“. Results: 841 patients (357 women, a 42’4%, and 484 men, a 57’65%) with a total of 7007 colorectal polyps and a medium follow-up of 66 +/- 21’84 months. During the following 12 patients were diagnosed of colorectal cancer, who had not had any statistical significant difference in “polyps rate per colonoscopy”, nor for the number of “advanced adenomas” (Z=0’11, p=0’91), nor for “total adenomatous polyps” (Z=1’84, p=0’07). Nevertheless, we could see that patients without colorectal cancer showed lower “polyps rate per colonoscopy” of advanced adenoma (Z=4’61, p <0’001) and raw number of polyps (Z=7’09, p <0’001). Conclusions: when comparing rates by number of patients, number of colonoscopic explorations and follow-up time, the advanced adenoma rate was found to be higher in patients who later developed colorectal carcinoma.
{"title":"Relationship Between Colorectal Carcinoma and Adenoma Detection Rate by Colonoscopy","authors":"F. Mendoza-Moreno, E. Ovejero-Merino, J. Ocaña, Fernando Noguerales-Fraguas, Belén Matías-García, Ana Quiroga-Valcárcel, Alma Blázquez-Martín, A. Minaya‐Bravo, A. Silva-Mato, Á. Gutiérrez","doi":"10.30476/ACRR.2021.89007.1074","DOIUrl":"https://doi.org/10.30476/ACRR.2021.89007.1074","url":null,"abstract":"Background: in recent years, colorectal cancer incidence has declined dramatically. Screening programs, based on endoscopic resection of polipoid precancerous lesions, are being fundamental in that desirable improvement. Material and methods: prospective observational study of a set of patients who had an endoscopic resection of colonic polipoid lesions from January-2007 to December-2012. We analized “polyps rate” by colonoscopy, number of patients, follow-up time, and “relationship with later cancer appearance“. Results: 841 patients (357 women, a 42’4%, and 484 men, a 57’65%) with a total of 7007 colorectal polyps and a medium follow-up of 66 +/- 21’84 months. During the following 12 patients were diagnosed of colorectal cancer, who had not had any statistical significant difference in “polyps rate per colonoscopy”, nor for the number of “advanced adenomas” (Z=0’11, p=0’91), nor for “total adenomatous polyps” (Z=1’84, p=0’07). Nevertheless, we could see that patients without colorectal cancer showed lower “polyps rate per colonoscopy” of advanced adenoma (Z=4’61, p <0’001) and raw number of polyps (Z=7’09, p <0’001). Conclusions: when comparing rates by number of patients, number of colonoscopic explorations and follow-up time, the advanced adenoma rate was found to be higher in patients who later developed colorectal carcinoma.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"28 1","pages":"192-199"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86042368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.30476/ACRR.2021.88825.1072
S. Hosseini, L. Ghahramani, S. Tayari, A. Izadi, Razieh Sadat Mousavi-roknabadi, Zahra Beizavi
Background: Transanal Total Mesorectal Excision (TaTME) presented in recent years as a novel technique to achieve better outcome in circumferential margin (CRM) and distal margin (DRM) in lower rectal cancer operation. The current study aimed to assess the perioperative and pathological characteristics of TaTME in comparison with laparoscopic total mesorectal excision (LaTME) in patients with mid- and low-rectal cancer. Methods: From January 2016 to December 2018, we enrolled all consecutive patients with rectal cancer, who underwent TaTME and LaTME. Primary endpoints like circumferential rectal margin (CRM) status, distal rectal margin (DRM) status, and pathological outcomes, as well as secondary endpoints including perioperative outcomes (total blood loss, duration of hospitalization, anastomosis leakage, as well as 30-day mortality) were evaluated and compared statistically (α=0.05). Results: 11 patients with distal rectal adenocarcinoma which was biopsy-proven, underwent TaTME, and 19 patients operated on using LaTME. Both groups were similar in the baseline characteristics. Also, the perioperative outcomes were similar in both groups. Regarding pathological outcomes, no patients with CRM Conclusion: TaTME is a reasonable procedure in patients with low rectal cancer. But no remarkable superiority was observed in this method compared to laparoscopy with respect to the pathological outcomes.
{"title":"Comparison of transanal versus laparoscopic total mesorectal excision in low rectal cancer","authors":"S. Hosseini, L. Ghahramani, S. Tayari, A. Izadi, Razieh Sadat Mousavi-roknabadi, Zahra Beizavi","doi":"10.30476/ACRR.2021.88825.1072","DOIUrl":"https://doi.org/10.30476/ACRR.2021.88825.1072","url":null,"abstract":"Background: Transanal Total Mesorectal Excision (TaTME) presented in recent years as a novel technique to achieve better outcome in circumferential margin (CRM) and distal margin (DRM) in lower rectal cancer operation. The current study aimed to assess the perioperative and pathological characteristics of TaTME in comparison with laparoscopic total mesorectal excision (LaTME) in patients with mid- and low-rectal cancer. Methods: From January 2016 to December 2018, we enrolled all consecutive patients with rectal cancer, who underwent TaTME and LaTME. Primary endpoints like circumferential rectal margin (CRM) status, distal rectal margin (DRM) status, and pathological outcomes, as well as secondary endpoints including perioperative outcomes (total blood loss, duration of hospitalization, anastomosis leakage, as well as 30-day mortality) were evaluated and compared statistically (α=0.05). Results: 11 patients with distal rectal adenocarcinoma which was biopsy-proven, underwent TaTME, and 19 patients operated on using LaTME. Both groups were similar in the baseline characteristics. Also, the perioperative outcomes were similar in both groups. Regarding pathological outcomes, no patients with CRM Conclusion: TaTME is a reasonable procedure in patients with low rectal cancer. But no remarkable superiority was observed in this method compared to laparoscopy with respect to the pathological outcomes.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"1993 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89041035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.30476/ACRR.2021.88624.1068
A. Tkachenko, A. Onishchenko
Introduction. The safety of generally recognized as safe food additives E407 and E407a is under rigorous debate. The aim of our research was to evaluate the effects of the orally administered food additive E407a (semi-refined carrageenan) on the viability of lymphocytes and their cell death modes. Methods. Totally, 16 adult WAG rats were divided into two equal groups (experimental – oral intake of 140 mg/kg of E407a during 2 weeks; control – oral consumption of drinking water instead). Blood samples were used to obtain leukocyte suspensions stained with Annexin V-FITC and 7-aminoactinomycin D (7-AAD). The region of lymphocytes was analyzed after collecting data using a BD FACSCanto™ II flow cytometer. Results. Oral administration of E407a led to a decrease in the amount of viable (Annexin V-, 7-AAD-) circulating lymphocytes. Furthermore, exposure to semi-refined carrageenan resulted in an elevated number of early apoptotic (Annexin V+, 7-AAD-) lymphocytes. Their percentage was approximately 4 times higher in rats exposed to E407a compared with the control group. Conclusion. Our findings indicate that dietary intake of E407a promotes apoptosis of circulating lymphocytes. Keywords: processed Eucheuma seaweed, annexin V, 7-aminoactinomycin D, flow cytometry.
{"title":"Oral Intake of Semi-refined Carrageenan by Rats Affects Apoptosis of Lymphocytes","authors":"A. Tkachenko, A. Onishchenko","doi":"10.30476/ACRR.2021.88624.1068","DOIUrl":"https://doi.org/10.30476/ACRR.2021.88624.1068","url":null,"abstract":"Introduction. The safety of generally recognized as safe food additives E407 and E407a is under rigorous debate. The aim of our research was to evaluate the effects of the orally administered food additive E407a (semi-refined carrageenan) on the viability of lymphocytes and their cell death modes. Methods. Totally, 16 adult WAG rats were divided into two equal groups (experimental – oral intake of 140 mg/kg of E407a during 2 weeks; control – oral consumption of drinking water instead). Blood samples were used to obtain leukocyte suspensions stained with Annexin V-FITC and 7-aminoactinomycin D (7-AAD). The region of lymphocytes was analyzed after collecting data using a BD FACSCanto™ II flow cytometer. Results. Oral administration of E407a led to a decrease in the amount of viable (Annexin V-, 7-AAD-) circulating lymphocytes. Furthermore, exposure to semi-refined carrageenan resulted in an elevated number of early apoptotic (Annexin V+, 7-AAD-) lymphocytes. Their percentage was approximately 4 times higher in rats exposed to E407a compared with the control group. Conclusion. Our findings indicate that dietary intake of E407a promotes apoptosis of circulating lymphocytes. Keywords: processed Eucheuma seaweed, annexin V, 7-aminoactinomycin D, flow cytometry.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"73 2 1","pages":"170-174"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83347868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.30476/ACRR.2020.87186.1054
H. Khazraei, S. Hosseini, Mozhdeh Zamani, Ahmed Mohammed Ali Hussein Al-Hurry, M. Rahimi, L. Ghahramani, Fahime Hosseini
Background: Fecal incontinence is an embarrassing problem and decreases the woman’s quality of life. The literature has shown that women with obstetric trauma especially by episiotomy had damaged anal sphincter (Internal and External). We aimed to find the role of episiotomy in the fecal incontinence in women after delivery. Methods: In this study, 71 females with previous vaginal deliveries were investigated by endoanal ultrasonography. The degree of FI was measured using the incontinence score of Wexner. The number of episiotomies was measured for each patient. Results: The mean Wexner score was 9.0±0.7 in the incontinent patients. The mean of normal vaginal delivery was 3.48±0.3 and 33.8% of the patients whom had a history of hemorrhoidectomy. Of patients, 70% had undergone one or more prior episiotomies during their deliveries. Conclusion: Episiotomy could be one of the risk factors in fecal incontinence but we did not find any significant difference in Wexner score between patients with or without episiotomy. Endoanal sonography seems an effective tool to evaluate and prediction of anal injury during episiotomy in some critical cases.
{"title":"Relationship between episiotomy and fecal incontinence after delivery","authors":"H. Khazraei, S. Hosseini, Mozhdeh Zamani, Ahmed Mohammed Ali Hussein Al-Hurry, M. Rahimi, L. Ghahramani, Fahime Hosseini","doi":"10.30476/ACRR.2020.87186.1054","DOIUrl":"https://doi.org/10.30476/ACRR.2020.87186.1054","url":null,"abstract":"Background: Fecal incontinence is an embarrassing problem and decreases the woman’s quality of life. The literature has shown that women with obstetric trauma especially by episiotomy had damaged anal sphincter (Internal and External). We aimed to find the role of episiotomy in the fecal incontinence in women after delivery. Methods: In this study, 71 females with previous vaginal deliveries were investigated by endoanal ultrasonography. The degree of FI was measured using the incontinence score of Wexner. The number of episiotomies was measured for each patient. Results: The mean Wexner score was 9.0±0.7 in the incontinent patients. The mean of normal vaginal delivery was 3.48±0.3 and 33.8% of the patients whom had a history of hemorrhoidectomy. Of patients, 70% had undergone one or more prior episiotomies during their deliveries. Conclusion: Episiotomy could be one of the risk factors in fecal incontinence but we did not find any significant difference in Wexner score between patients with or without episiotomy. Endoanal sonography seems an effective tool to evaluate and prediction of anal injury during episiotomy in some critical cases.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"1 1","pages":"136-140"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84389238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.30476/ACRR.2020.85927.1040
R. Vincenti, F. Cianchi, F. Coratti
Introduction. Interest in transanal endoscopic surgery has increased in the last decade. This approach allows primary procedures such as polypectomy, local tumor excision, as well as the treatment of postoperative complications including bleeding, leakage and fistula formation. The aim of this study was to describe our group’s use of Transanal endoscopic operation (TEO) in the repair of fistulae and anastomotic leakage, performed by one experienced surgeon (F.C.). Case presentation. Here, we describe three patients who developed postoperative complications after been subjected to anterior rectal resection. One of them developed a leakage of the anastomosis in third postoperative day, the others developed recurrent fistulae a long time after the surgery. These complications were all treated using TEO (transanal endoscopic operation) platform. The transanal procedure in one case was performed three times, because of the recurrence of the fistula. In another case it was associated with laparoscopy to treat peritonitis occurred after anastomotic disruption. In the last case, the patient had history of years of fistula recurrence associated with pelvic abscess, TEO approach proved to be determinant in the resolution of the problem. In all cases the transanal surgery definitively repaired the defect, the patients were discharged and, up to date, they are without recurrence. Conclusions. Thus, in the hands of experienced surgeons and in selected cases, TEO system appears to be a valid option to treat post-operative complications, such as fistulae and anastomotic leakage, avoiding major surgery with greater associated morbidity and showing excellent results.
{"title":"Transanal endoscopic operation (TEO) repair of rectovaginal fistula and anastomotic leakage: a case series","authors":"R. Vincenti, F. Cianchi, F. Coratti","doi":"10.30476/ACRR.2020.85927.1040","DOIUrl":"https://doi.org/10.30476/ACRR.2020.85927.1040","url":null,"abstract":"Introduction. Interest in transanal endoscopic surgery has increased in the last decade. This approach allows primary procedures such as polypectomy, local tumor excision, as well as the treatment of postoperative complications including bleeding, leakage and fistula formation. The aim of this study was to describe our group’s use of Transanal endoscopic operation (TEO) in the repair of fistulae and anastomotic leakage, performed by one experienced surgeon (F.C.). Case presentation. Here, we describe three patients who developed postoperative complications after been subjected to anterior rectal resection. One of them developed a leakage of the anastomosis in third postoperative day, the others developed recurrent fistulae a long time after the surgery. These complications were all treated using TEO (transanal endoscopic operation) platform. The transanal procedure in one case was performed three times, because of the recurrence of the fistula. In another case it was associated with laparoscopy to treat peritonitis occurred after anastomotic disruption. In the last case, the patient had history of years of fistula recurrence associated with pelvic abscess, TEO approach proved to be determinant in the resolution of the problem. In all cases the transanal surgery definitively repaired the defect, the patients were discharged and, up to date, they are without recurrence. Conclusions. Thus, in the hands of experienced surgeons and in selected cases, TEO system appears to be a valid option to treat post-operative complications, such as fistulae and anastomotic leakage, avoiding major surgery with greater associated morbidity and showing excellent results.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"25 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86072640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.30476/ACRR.2020.46945
T. Singhal, J. Dudek, A. Sharmin, M. Sudhanva, A. Hussain, S. El-Hasani
Background: Covid-19 crisis has created a huge challenge to the healthcare systems all over the world. Different health policies have been adopted with variable success. This paper aims to provide a practical pathway of managing surgical patients in current Covid-19 pandemic. Methods: A modified framework of local policy and pathways is suggested to deal with acute surgical admissions and semi-emergency conditions. This included logistic changes in the hospitals' infrastructures, staff allocations and the use of suitable personal protection equipment. Results: The introduction of the suggested changes is expected to improve the delivery of the services and reduce risks to patients and the staff. About 80 operations were conducted since the application of these changes. Conclusion: Challenges with Covid-19 pandemic has required each health system to adequately respond to the crisis by the introduction of an urgent fundamental change to the current surgical practice and is likely to change the management and local policies of each hospital after the crisis.
{"title":"Ground plan for performing Emergency Surgery in suspected and confirmed COVID-19 patients","authors":"T. Singhal, J. Dudek, A. Sharmin, M. Sudhanva, A. Hussain, S. El-Hasani","doi":"10.30476/ACRR.2020.46945","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46945","url":null,"abstract":"Background: Covid-19 crisis has created a huge challenge to the healthcare systems all over the world. Different health policies have been adopted with variable success. This paper aims to provide a practical pathway of managing surgical patients in current Covid-19 pandemic. Methods: A modified framework of local policy and pathways is suggested to deal with acute surgical admissions and semi-emergency conditions. This included logistic changes in the hospitals' infrastructures, staff allocations and the use of suitable personal protection equipment. Results: The introduction of the suggested changes is expected to improve the delivery of the services and reduce risks to patients and the staff. About 80 operations were conducted since the application of these changes. Conclusion: Challenges with Covid-19 pandemic has required each health system to adequately respond to the crisis by the introduction of an urgent fundamental change to the current surgical practice and is likely to change the management and local policies of each hospital after the crisis.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"41 1","pages":"129-135"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87489293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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