Occult rectal prolapse is a pathological condition that mainly affects women and is frequently associated with obstructed defecation.Numerous surgical procedures have been advocated for treating patients with obstructed defecation. In this study, we performeda retrospective analysis of the short-term surgical outcomes of combining internal mucosal resection with transverse perinealsupport in a single center with expertise in anorectal surgery. Resolution in obstruction symptoms was achieved with lowmorbidity. The use of sleeve resection of the rectal mucosa is a well-known and established procedure for occult rectal prolapse inobstructed defecation syndrome patients. Transverse perineal support operation has been recently adopted to correct defects ofthe perineum. In our preliminary experience, we report a combination in surgical techniques never described in the literature. Ourpreliminary results suggest that the technique is feasible, safe and reproducible. More patients and longer follow-up are requiredto be able to draw stronger conclusions.
{"title":"Short-Term Outcomes of Rectal Mucosa Sleeve Resection and Transverse Perineal Support Operation for Occult Rectal Prolapse, Rectocele and Descending Perineum: A Single Center and Single Team Experience","authors":"F. Cantarella, E. Magni","doi":"10.5812/ACR.89956","DOIUrl":"https://doi.org/10.5812/ACR.89956","url":null,"abstract":"Occult rectal prolapse is a pathological condition that mainly affects women and is frequently associated with obstructed defecation.Numerous surgical procedures have been advocated for treating patients with obstructed defecation. In this study, we performeda retrospective analysis of the short-term surgical outcomes of combining internal mucosal resection with transverse perinealsupport in a single center with expertise in anorectal surgery. Resolution in obstruction symptoms was achieved with lowmorbidity. The use of sleeve resection of the rectal mucosa is a well-known and established procedure for occult rectal prolapse inobstructed defecation syndrome patients. Transverse perineal support operation has been recently adopted to correct defects ofthe perineum. In our preliminary experience, we report a combination in surgical techniques never described in the literature. Ourpreliminary results suggest that the technique is feasible, safe and reproducible. More patients and longer follow-up are requiredto be able to draw stronger conclusions.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89203856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bang Guy Aristide, Nana Oumarou Blondel, S. E. Patrick, B. Georges, Essomba Arthur Georges
surgery is associated with lower morbidity and mortality. However, the laparoscopic approach to the management of peritonitis remains marginalized in low and middle-income countries (LMICs) due to financial and technical limitations.Methods: We conducted a seven-year prospective study on patients with acute generalized peritonitis in Yaounde, Cameroon. Inclusion criteria were an age range of between 5 to 55 years, admission within 48 hours after the onset of symptoms, hemodynamic stability, and no major comorbidities. Excluded from this study were patients with colonic perforation, prior history of abdominal surgery, or primary and localized peritonitis after proper resuscitation. The patients included were managed via laparoscopy; operative and postoperative data were collected and analyzed. Some technical artifices were used to circumvent the lack of standardequipment. Results: The study involved twenty-five patients with a mean age of 32.1 years. The etiology of peritonitis was identified as appendicitis in 20 cases, perforated duodenal ulcer in 2 cases, gastric ulcer perforation in 2 cases, and jejunal perforation in 1 case. In two cases (8%), the operation was onverted to laparotomy. The postoperative course was uneventful in 21 cases (84%), whereas morbidity was seen in 4 cases (16%); no mortality was recorded. The mean length of hospital stay was 5.5 days.Conclusions: This study demonstrates that the laparoscopic management of acute generalized peritonitis in African LMICs is afeasible, safe, and effective surgical option in properly selected patients.
{"title":"Feasibility and Outcome of Laparoscopic Approach for Acute Generalized Peritonitis in Africa: Single Low-Center Results After 25 Consecutive Cases in Cameroon","authors":"Bang Guy Aristide, Nana Oumarou Blondel, S. E. Patrick, B. Georges, Essomba Arthur Georges","doi":"10.5812/ACR.90905","DOIUrl":"https://doi.org/10.5812/ACR.90905","url":null,"abstract":"surgery is associated with lower morbidity and mortality. However, the laparoscopic approach to the management of peritonitis remains marginalized in low and middle-income countries (LMICs) due to financial and technical limitations.Methods: We conducted a seven-year prospective study on patients with acute generalized peritonitis in Yaounde, Cameroon. Inclusion criteria were an age range of between 5 to 55 years, admission within 48 hours after the onset of symptoms, hemodynamic stability, and no major comorbidities. Excluded from this study were patients with colonic perforation, prior history of abdominal surgery, or primary and localized peritonitis after proper resuscitation. The patients included were managed via laparoscopy; operative and postoperative data were collected and analyzed. Some technical artifices were used to circumvent the lack of standardequipment. \u0000Results: The study involved twenty-five patients with a mean age of 32.1 years. The etiology of peritonitis was identified as appendicitis in 20 cases, perforated duodenal ulcer in 2 cases, gastric ulcer perforation in 2 cases, and jejunal perforation in 1 case. In two cases (8%), the operation was onverted to laparotomy. The postoperative course was uneventful in 21 cases (84%), whereas morbidity was seen in 4 cases (16%); no mortality was recorded. The mean length of hospital stay was 5.5 days.Conclusions: This study demonstrates that the laparoscopic management of acute generalized peritonitis in African LMICs is afeasible, safe, and effective surgical option in properly selected patients.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74338556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Tanoğlu, O. Tekin, T. Duzenli, M. Kara, M. Kaplan, Irfan Kucuk, Onur Ozarı, Y. Yazgan
Ulcerative colitis is a chronic inflammatory disease affecting mainly the colon and presenting with diarrhea, bloody defecation and abdominal pain. Although cardiac and/or pulmonary involvement has been reported in patients with ulcerative colitis, it rarely involves both the pleura and pericardium at the same time. Also, it is difficult to determine whether pulmonary or cardiac disease is secondary to the ulcerative colitis drugs or to the underlying disease process. Here we present a rare case of pleuropericardial effusion in a patient newly diagnosed with ulcerative colitis. In ulcerative colitis, the simultaneous involvement of the respiratory and cardiovascular systems is uncommon yet potentially dangerous.
{"title":"A Diagnostic Conundrum in a Newly Diagnosed Ulcerative Colitis Patient Who Presented with Pleuropericardial Effusion","authors":"A. Tanoğlu, O. Tekin, T. Duzenli, M. Kara, M. Kaplan, Irfan Kucuk, Onur Ozarı, Y. Yazgan","doi":"10.5812/ACR.84743","DOIUrl":"https://doi.org/10.5812/ACR.84743","url":null,"abstract":"Ulcerative colitis is a chronic inflammatory disease affecting mainly the colon and presenting with diarrhea, bloody defecation and abdominal pain. Although cardiac and/or pulmonary involvement has been reported in patients with ulcerative colitis, it rarely involves both the pleura and pericardium at the same time. Also, it is difficult to determine whether pulmonary or cardiac disease is secondary to the ulcerative colitis drugs or to the underlying disease process. Here we present a rare case of pleuropericardial effusion in a patient newly diagnosed with ulcerative colitis. In ulcerative colitis, the simultaneous involvement of the respiratory and cardiovascular systems is uncommon yet potentially dangerous.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81806698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ping-shan Yang, Xiu-Feng Lin, Chen Xie, Fan Luo, Hai Liang, Wei Li
Background: Nasogastric decompression is routinely used for intestinal drainage or decompression after gastrectomy. However, nowadays its efficacy is under debate. Objectives: The purpose of this study was to investigate the efficacy and necessity of nasogastric decompression in radical gastrectomy for gastric cancer. Methods: Two PubMed and EMBASE electronic databases were retrieved by November 2018. A prospective randomized controlled trial (RCT) and comparison of nasogastric decompression with and without nasogastric decompression after gastrectomy are required for eligible studies. Results: A total of 1,885 cases were included in 13 randomized controlled studies. There were 941 cases in nasogastric decompression group and 944 cases in non-nasogastric decompression group after gastrectomy. The patients in non-nasogastric decompression group had significantly shorter time of bowel sound return (WMD = -0.20, 95% CIs = -0.38 0.02, P = 0.03), shorter time of first oral intake (WMD = -0.58, 95% CIs = -0.92 0.24, P = 0.0007), faster tolerance to semi-solid diet (WMD = -0.65, 95% CIs = -0.96 0.34, P < 0.0001), and shorter time of postoperative hospital stay (WMD = -0.99, 95% CIs = -1.70 0.27, P = 0.007). No statistically significant differences were observed in the first time to passage of flatus, vomiting, mortality rates, total complications, gastrointestinal complications, wound complications, respiratory complications, anastomosis or duodenal stump fistula, and general complications. Conclusions: The routine nasogastric decompression was not recommended for patients after elective gastrectomy.
背景:胃切除术后常规应用鼻胃减压进行肠引流或减压。然而，如今它的功效却备受争议。目的:探讨鼻胃减压术在胃癌根治术中的疗效和必要性。方法:2018年11月检索PubMed和EMBASE两个电子数据库。符合条件的研究需要前瞻性随机对照试验(RCT)和胃切除术后鼻胃减压与不进行鼻胃减压的比较。结果:13项随机对照研究共纳入1885例。胃切除术后鼻胃减压组941例，非鼻胃减压组944例。非鼻胃减压组患者肠声恢复时间显著缩短(WMD = -0.20, 95% ci = -0.38 0.02, P = 0.03)，首次口服时间显著缩短(WMD = -0.58, 95% ci = -0.92 0.24, P = 0.0007)，对半固体饮食耐受较快(WMD = -0.65, 95% ci = -0.96 0.34, P < 0.0001)，术后住院时间显著缩短(WMD = -0.99, 95% ci = -1.70 0.27, P = 0.007)。两组在首次排气、呕吐、死亡率、总并发症、胃肠道并发症、伤口并发症、呼吸并发症、吻合口或十二指肠残端瘘、一般并发症方面差异无统计学意义。结论:择期胃切除术后不推荐常规鼻胃减压。
{"title":"Pooled Analysis of the Routine Nasogastric Decompression Necessity for Elective Gastrectomy","authors":"Ping-shan Yang, Xiu-Feng Lin, Chen Xie, Fan Luo, Hai Liang, Wei Li","doi":"10.5812/ACR.88990","DOIUrl":"https://doi.org/10.5812/ACR.88990","url":null,"abstract":"Background: Nasogastric decompression is routinely used for intestinal drainage or decompression after gastrectomy. However, nowadays its efficacy is under debate. Objectives: The purpose of this study was to investigate the efficacy and necessity of nasogastric decompression in radical gastrectomy for gastric cancer. Methods: Two PubMed and EMBASE electronic databases were retrieved by November 2018. A prospective randomized controlled trial (RCT) and comparison of nasogastric decompression with and without nasogastric decompression after gastrectomy are required for eligible studies. Results: A total of 1,885 cases were included in 13 randomized controlled studies. There were 941 cases in nasogastric decompression group and 944 cases in non-nasogastric decompression group after gastrectomy. The patients in non-nasogastric decompression group had significantly shorter time of bowel sound return (WMD = -0.20, 95% CIs = -0.38 0.02, P = 0.03), shorter time of first oral intake (WMD = -0.58, 95% CIs = -0.92 0.24, P = 0.0007), faster tolerance to semi-solid diet (WMD = -0.65, 95% CIs = -0.96 0.34, P < 0.0001), and shorter time of postoperative hospital stay (WMD = -0.99, 95% CIs = -1.70 0.27, P = 0.007). No statistically significant differences were observed in the first time to passage of flatus, vomiting, mortality rates, total complications, gastrointestinal complications, wound complications, respiratory complications, anastomosis or duodenal stump fistula, and general complications. Conclusions: The routine nasogastric decompression was not recommended for patients after elective gastrectomy.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83815842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The significance of nodal metastasis as a prognostic factor in colorectal cancer is universally recognised and accepted. This article discusses the various factors that govern lymph node harvest and how to improve that. We will discuss the outcome of lymph node harvest as a possible form of auditing the surgical technique and the pathologist dedication.
{"title":"Lymph Node Status in Colorectal Cancer; Is There a Case for Auditing the Pathologist and the Surgeon?","authors":"E. Salmo, N. Haboubi","doi":"10.5812/ACR.83979","DOIUrl":"https://doi.org/10.5812/ACR.83979","url":null,"abstract":"The significance of nodal metastasis as a prognostic factor in colorectal cancer is universally recognised and accepted. This article discusses the various factors that govern lymph node harvest and how to improve that. We will discuss the outcome of lymph node harvest as a possible form of auditing the surgical technique and the pathologist dedication.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90119467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Nejati, Jamileh Abedi, M. Saatloo, Maryam Koohsoltani, R. Hobbenaghi, A. Tukmachi
Background: Colorectal cancer is one of the most common causes of mortality in the world. Objectives: The aim of this study was to investigate the histopathologic changes including hyperchromatism, tissue lymphocyte infiltrations (TILs), aberrant crypt foci (ACF), microvessel density (MVD), p53, Bcl-2 and CD31 changes during colorectal cancer development. Methods: Subcutaneous injections of dimethyl hydrazine DMH were administered to rats (40 mg/kg body weight) for 10 weeks. Rats were fed by food and water until 40th week and sacrificed two by two within 10, 15, 20, 25, 30 and 40 weeks after the start of treatment. Thin paraffinized sections were applied to anti-CD31, anti-Bcl-2 and anti-p53 staining procedures. MVD and ACF were reported as mean value of three HPFs. Results: Hyperchromatism, TILs and angiogenesis were the most common initial histologic changes which started at 10th week of DMH treatment. Hyperchromatism’s severity increased earlier than other changes and reached the highest value at the 25th week. The highest value of all variants occurred in the 40th week except the TILs which started to achieve the highest value in week 30 and increased until 40th week. A diminished amount of p53 was observed at week 40, however, increased intensity of CD31 and Bcl-2 were seen between 30th and 40th week. Conclusions: In conclusion, TILs and angiogenesis might be the important earliest factors contributing to colorectal cancer progression.
{"title":"Gradual Histopathologic Changes During Development of Colorectal Cancer","authors":"V. Nejati, Jamileh Abedi, M. Saatloo, Maryam Koohsoltani, R. Hobbenaghi, A. Tukmachi","doi":"10.5812/ACR.87080","DOIUrl":"https://doi.org/10.5812/ACR.87080","url":null,"abstract":"Background: Colorectal cancer is one of the most common causes of mortality in the world. Objectives: The aim of this study was to investigate the histopathologic changes including hyperchromatism, tissue lymphocyte infiltrations (TILs), aberrant crypt foci (ACF), microvessel density (MVD), p53, Bcl-2 and CD31 changes during colorectal cancer development. Methods: Subcutaneous injections of dimethyl hydrazine DMH were administered to rats (40 mg/kg body weight) for 10 weeks. Rats were fed by food and water until 40th week and sacrificed two by two within 10, 15, 20, 25, 30 and 40 weeks after the start of treatment. Thin paraffinized sections were applied to anti-CD31, anti-Bcl-2 and anti-p53 staining procedures. MVD and ACF were reported as mean value of three HPFs. Results: Hyperchromatism, TILs and angiogenesis were the most common initial histologic changes which started at 10th week of DMH treatment. Hyperchromatism’s severity increased earlier than other changes and reached the highest value at the 25th week. The highest value of all variants occurred in the 40th week except the TILs which started to achieve the highest value in week 30 and increased until 40th week. A diminished amount of p53 was observed at week 40, however, increased intensity of CD31 and Bcl-2 were seen between 30th and 40th week. Conclusions: In conclusion, TILs and angiogenesis might be the important earliest factors contributing to colorectal cancer progression.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83103821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Editor, mosquito borne infectious diseases are an important group of infections. The arbovirus infection is the present global public health consideration. The disease is observable in several countries. Of several mosquito-borne infectious diseases, dengue is an important arbovirus infection (1). This viral infection is seen in several countries. This viral infection usually manifests as acute febrile illness. The hemorrhagic complication due to the thrombocytopenia is common in dengue (1). The main clinical problem due to dengue is fever and hemorrhagic problem. The atypical clinical presentation can also be seen. The inter-relationship between dengue and other medical disorders is interesting. The inter-relationship between dengue and colorectal disease is very interesting yet little is mentioned in the literature. In this article, the authors specifically discussed on this specific issue.
{"title":"Dengue and Colorectal Disease","authors":"V. Wiwanitkit","doi":"10.5812/ACR.87992","DOIUrl":"https://doi.org/10.5812/ACR.87992","url":null,"abstract":"Dear Editor, mosquito borne infectious diseases are an important group of infections. The arbovirus infection is the present global public health consideration. The disease is observable in several countries. Of several mosquito-borne infectious diseases, dengue is an important arbovirus infection (1). This viral infection is seen in several countries. This viral infection usually manifests as acute febrile illness. The hemorrhagic complication due to the thrombocytopenia is common in dengue (1). The main clinical problem due to dengue is fever and hemorrhagic problem. The atypical clinical presentation can also be seen. The inter-relationship between dengue and other medical disorders is interesting. The inter-relationship between dengue and colorectal disease is very interesting yet little is mentioned in the literature. In this article, the authors specifically discussed on this specific issue.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83802023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brenna L. Hennessey, L. Schwarzman, D. Mutabdzic, Sameer A. Patel, A. Olszanski, S. Hayes, Hong Wu, J. Meyer, S. Reddy
Introduction: Squamoid eccrine carcinoma is a very rare carcinoma with few reported cases in the literature. As a result, there is limited guidance on management and follow-up of these cases. Case Presentation: We describe the case of a 39 year-old male with a large painful squamoid eccrine carcinoma of the right lower abdominal wall with inguinal nodal involvement. He underwent radical resection, superficial groin dissection, transposition of a sartorius muscle flap, and a pedicled anterolateral thigh perforator flap for reconstruction. The postoperative course was uneventful apart from a postoperative seroma which was treated with aspiration. He underwent adjuvant radiation following full recovery
{"title":"An Unusual Case of Squamoid Eccrine Carcinoma of the Abdominal Wall with Inguinal Nodal Metastases: A Case Report and Review of the Literature","authors":"Brenna L. Hennessey, L. Schwarzman, D. Mutabdzic, Sameer A. Patel, A. Olszanski, S. Hayes, Hong Wu, J. Meyer, S. Reddy","doi":"10.5812/ACR.83511","DOIUrl":"https://doi.org/10.5812/ACR.83511","url":null,"abstract":"Introduction: Squamoid eccrine carcinoma is a very rare carcinoma with few reported cases in the literature. As a result, there is limited guidance on management and follow-up of these cases. Case Presentation: We describe the case of a 39 year-old male with a large painful squamoid eccrine carcinoma of the right lower abdominal wall with inguinal nodal involvement. He underwent radical resection, superficial groin dissection, transposition of a sartorius muscle flap, and a pedicled anterolateral thigh perforator flap for reconstruction. The postoperative course was uneventful apart from a postoperative seroma which was treated with aspiration. He underwent adjuvant radiation following full recovery","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79186768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colorectal cancer (CRC) is still the third most common cancer in the world, which is the fourth cause of cancer-related mortality. It is caused either due to strong genetic factors such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colon cancer or due to modified metabolic factors such as obesity and diabetes, which represents insulin resistance condition. Non-alcoholic fatty liver disease (NAFLD) is increasing not only in Western countries but also in Asian countries. This disease has been included in the metabolic disease family such as diabetes, hypertension, obesity, and dyslipidemia. Some studies have shown that there is a strong association between NAFLD and the risk of CRC development through the presence of an adenomatous polyp. However, there is currently no consensus on whether routine screening colonoscopy should be done in all NAFLD patients with respects to its cost
{"title":"Non-Alcoholic Fatty Liver Disease as a Risk for Colorectal Cancer Development and the Role of Screening Colonoscopy in Clinical Practice","authors":"C. Lesmana, M. Lirendra, L. Lesmana","doi":"10.5812/ACR.88488","DOIUrl":"https://doi.org/10.5812/ACR.88488","url":null,"abstract":"Colorectal cancer (CRC) is still the third most common cancer in the world, which is the fourth cause of cancer-related mortality. It is caused either due to strong genetic factors such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colon cancer or due to modified metabolic factors such as obesity and diabetes, which represents insulin resistance condition. Non-alcoholic fatty liver disease (NAFLD) is increasing not only in Western countries but also in Asian countries. This disease has been included in the metabolic disease family such as diabetes, hypertension, obesity, and dyslipidemia. Some studies have shown that there is a strong association between NAFLD and the risk of CRC development through the presence of an adenomatous polyp. However, there is currently no consensus on whether routine screening colonoscopy should be done in all NAFLD patients with respects to its cost","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"164 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73267746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kelly B. Scarberry, Justin T. Brady, K. Scarberry, S. Stein, E. Steinhagen
Background: Crohn’s disease (CD) has significant effects on quality of life. There is a paucity of information regarding how surgery for CD affects male sexual function. Objectives: To determine the effects of surgery for CD on male sexual function. Methods: A survey was sent to male patients who had surgery for CD at a tertiary care institution between January 1st, 2011 and July 1st, 2016. The survey included the Patient Health Questionnaire (PHQ-9), short inflammatory bowel disease questionnaire (SIBDQ), and the international index of erectile function (IIEF-5). A retrospective chart review was performed. Statistical analysis was performed using Fischer’s exact test and two-sided t-test. Results: The survey was sent to 149 men and twenty-one patients (14%) responded. The mean age of respondents was 54.9 years. On analysis of patients who completed the IIEF-5, 12 patients (63%) met criteria for erectile dysfunction (ED). Ten patients subjectively reported worsened sexual function following surgery (48%). Men who had previously undergone surgery for CD were more likely to have ED (P = 0.01). Patients who met criteria for depression were more likely to have ED (P = 0.006). Men with more CD symptoms were more likely to have ED: the mean SIBDQ score for men with ED was 4.5, while the mean score for men without ED was 5.8 (P = 0.01). Conclusions: Men who undergo surgery for CD experience high rates of sexual dysfunction, with many men reporting their sexual functioned worsened following surgery. More research needs to be done to further characterize sexual dysfunction in men with CD.
{"title":"Surgery for Crohn’s Disease Affects Male Sexual Function","authors":"Kelly B. Scarberry, Justin T. Brady, K. Scarberry, S. Stein, E. Steinhagen","doi":"10.5812/ACR.85458","DOIUrl":"https://doi.org/10.5812/ACR.85458","url":null,"abstract":"Background: Crohn’s disease (CD) has significant effects on quality of life. There is a paucity of information regarding how surgery for CD affects male sexual function. Objectives: To determine the effects of surgery for CD on male sexual function. Methods: A survey was sent to male patients who had surgery for CD at a tertiary care institution between January 1st, 2011 and July 1st, 2016. The survey included the Patient Health Questionnaire (PHQ-9), short inflammatory bowel disease questionnaire (SIBDQ), and the international index of erectile function (IIEF-5). A retrospective chart review was performed. Statistical analysis was performed using Fischer’s exact test and two-sided t-test. Results: The survey was sent to 149 men and twenty-one patients (14%) responded. The mean age of respondents was 54.9 years. On analysis of patients who completed the IIEF-5, 12 patients (63%) met criteria for erectile dysfunction (ED). Ten patients subjectively reported worsened sexual function following surgery (48%). Men who had previously undergone surgery for CD were more likely to have ED (P = 0.01). Patients who met criteria for depression were more likely to have ED (P = 0.006). Men with more CD symptoms were more likely to have ED: the mean SIBDQ score for men with ED was 4.5, while the mean score for men without ED was 5.8 (P = 0.01). Conclusions: Men who undergo surgery for CD experience high rates of sexual dysfunction, with many men reporting their sexual functioned worsened following surgery. More research needs to be done to further characterize sexual dysfunction in men with CD.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85948271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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