Pub Date : 2020-06-01DOI: 10.30476/ACRR.2020.46747
M. Marzban, Sara Kashefian Naeeini, Arash Ghazbani, Z. Karimi
Introduction: Gut microbiota is a major component of the intestinal luminal environment and plays important roles in colorectal cancer. Object: systematically review all the existing literature on the association of mucosa-associated and fecal microbiota with incidence, location, and stage of colorectal adenoma and carcinoma. Methods: The scientific search was done up to July 2018. The search was limited to the English language with predefined and proper keywords. Among 616 articles some of them were eliminated due to some reasons. The inclusion and exclusion criteria were defined. In the next step two reviewers (M.M and Z.K) independently scanned the titles of all retrieved articles, removed duplicates, and identified potentially relevant abstracts for further assessment. The Newcastle-Ottawa Scale (NOS) for assessing the Quality was used for quality control. Result: Finally, 54 articles were entered into the study. Fusobacteria 39 (72%), Firmicutes 22(40%), Bacteroidetes 20 (37%), Proteobacteria 15(27%), Actinobacteria 10(18%) was the most prevalent phylum which was found in colorectal cancer patients. Among these taxa some of them were increased in colorectal cancer patients compared to the control; on the other hand, some taxon was declined in colorectal cancer patients. Besides this, in some taxon there were controversies among articles. Conclusion: Early detection of CRC is essential because patients whose cancer are detected at an early stage have more chance of survival. Until now there are several studies have demonstrated the potential rule of gut microbiota to be used for detection of CRC, but there is not any predefining protocol for screening. Although we found lots of articles which were published in this area, for defining a precise microbiota profile we need large multicenter case-control studies, where can show the effect of most important confounding factors like nutrition, ethnicity, physical activity, smoking consumption, and genetic background.
{"title":"Systematic Review of Fecal and Mucosa-Associated Microbiota Compositional Shifts in Colorectal Cancer","authors":"M. Marzban, Sara Kashefian Naeeini, Arash Ghazbani, Z. Karimi","doi":"10.30476/ACRR.2020.46747","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46747","url":null,"abstract":"Introduction: Gut microbiota is a major component of the intestinal luminal environment and plays important roles in colorectal cancer. Object: systematically review all the existing literature on the association of mucosa-associated and fecal microbiota with incidence, location, and stage of colorectal adenoma and carcinoma. Methods: The scientific search was done up to July 2018. The search was limited to the English language with predefined and proper keywords. Among 616 articles some of them were eliminated due to some reasons. The inclusion and exclusion criteria were defined. In the next step two reviewers (M.M and Z.K) independently scanned the titles of all retrieved articles, removed duplicates, and identified potentially relevant abstracts for further assessment. The Newcastle-Ottawa Scale (NOS) for assessing the Quality was used for quality control. Result: Finally, 54 articles were entered into the study. Fusobacteria 39 (72%), Firmicutes 22(40%), Bacteroidetes 20 (37%), Proteobacteria 15(27%), Actinobacteria 10(18%) was the most prevalent phylum which was found in colorectal cancer patients. Among these taxa some of them were increased in colorectal cancer patients compared to the control; on the other hand, some taxon was declined in colorectal cancer patients. Besides this, in some taxon there were controversies among articles. Conclusion: Early detection of CRC is essential because patients whose cancer are detected at an early stage have more chance of survival. Until now there are several studies have demonstrated the potential rule of gut microbiota to be used for detection of CRC, but there is not any predefining protocol for screening. Although we found lots of articles which were published in this area, for defining a precise microbiota profile we need large multicenter case-control studies, where can show the effect of most important confounding factors like nutrition, ethnicity, physical activity, smoking consumption, and genetic background.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"61 1","pages":"41-64"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83867088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.30476/ACRR.2020.46700
F. Cantarella, E. Magni
Short term outcomes of Endoscopic Pilonidal Sinus Laser Treatment: a Single Centre experience. Pilonidal sinus (PS) is a widespread pathologic condition. The etiology of Pilonidal Disease (PD) is in favor of an acquired cause. Multiple surgical options have been advocated. In the last few years a minimally invasive approach to PD has been proposed. We performed a retrospective analysis of short-term surgical outcomes of combining EpSiT approach with the use of a radial laser fiber in the treatment of PD in a Single Centre. At our Proctology Centre, we performed 10 consecutive Endoscopic Pilonidal Sinus Laser Treatment procedures in the period from march 2019 to september 2019. The review of our initial experience suggests that the combination of fistuloscopy and laser ablation in treating fistulizing PD is feasible, safe and reproducible. Pilonidal sinus (PS) is a widespread pathologic condition. The etiology of Pilonidal Disease (PD) is in favor of an acquired cause. Multiple surgical options have been advocated. In the last few years a minimally invasive approach to PD has been proposed. We performed a retrospective analysis of short-term surgical outcomes of combining EpSiT approach with the use of a radial laser fiber in the treatment of PD in a Single Centre. At our Proctology Centre, we performed 10 consecutive Endoscopic Pilonidal Sinus Laser Treatment procedures in the period from march 2019 to september 2019. The review of our initial experience suggests that the combination of fistuloscopy and laser ablation in treating fistulizing PD is feasible, safe and reproducible
{"title":"Short term outcomes of Endoscopic Pilonidal Sinus Laser Treatment: a Single Centre experience.","authors":"F. Cantarella, E. Magni","doi":"10.30476/ACRR.2020.46700","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46700","url":null,"abstract":"Short term outcomes of Endoscopic Pilonidal Sinus Laser Treatment: a Single Centre experience. Pilonidal sinus (PS) is a widespread pathologic condition. The etiology of Pilonidal Disease (PD) is in favor of an acquired cause. Multiple surgical options have been advocated. In the last few years a minimally invasive approach to PD has been proposed. We performed a retrospective analysis of short-term surgical outcomes of combining EpSiT approach with the use of a radial laser fiber in the treatment of PD in a Single Centre. At our Proctology Centre, we performed 10 consecutive Endoscopic Pilonidal Sinus Laser Treatment procedures in the period from march 2019 to september 2019. The review of our initial experience suggests that the combination of fistuloscopy and laser ablation in treating fistulizing PD is feasible, safe and reproducible. Pilonidal sinus (PS) is a widespread pathologic condition. The etiology of Pilonidal Disease (PD) is in favor of an acquired cause. Multiple surgical options have been advocated. In the last few years a minimally invasive approach to PD has been proposed. We performed a retrospective analysis of short-term surgical outcomes of combining EpSiT approach with the use of a radial laser fiber in the treatment of PD in a Single Centre. At our Proctology Centre, we performed 10 consecutive Endoscopic Pilonidal Sinus Laser Treatment procedures in the period from march 2019 to september 2019. The review of our initial experience suggests that the combination of fistuloscopy and laser ablation in treating fistulizing PD is feasible, safe and reproducible","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"28 1","pages":"93-96"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84902280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.30476/ACRR.2020.46748
J. C. Bernal-Sprekelsen, L. Romero, J. Soriano, J. Plá, G. Cortés, A. Abellán
Abstract Background Due to its multiple forms of debut hidradenitis suppurativa has classically been a diagnostic challenge as well in the differential diagnosis. Prevalence of perianal fistula in patients with hidradenitis suppurativa ranges form 6,6% to 67%. The aim of the study was to assess both conditions. Methods A retrospective chart review from 2000 to 2018 using the ICD-9-CM, coded with 705.83. for patients with hidradenitis suppurativa was conducted. Hurley’s three stage classification was applied. Diagnosis and relevant patient characteristics were assessed and the presence of associated perianal fistula. Endoa-nal ultrasound (EAU) was performed in 61% of the patients with perianal hidradenitis and perianal fistu-la, and magnetic resonance imaging (MRI) in 19%. Results Of 143 cases with hidradenitis, sixty two cases (43,4%) presented perianal (perineal/buttocks) location. Of them 93,5% were men. Twenty-one percent were associated with perianal fistulas being 6 of them complex ones associated with Hurley stage II and III. Treatment for the latter included: loose setons in 4 patients with Crohn’s disease and in 2 non Crohn’s disease with complex fistulas, 4 fistulotomies and 2 fistulectomies in low transphincteric fistulas and 1 with incision and drainage. Conclusion Perianal fistula should be treated according to associated diseases and type of fistula. Association of hidradenitis and perianal fistulas may be higher than expected and the relation of severe hidradenitis with complex perianal fistulas should be studied further. Endoanal ultrasound and MRI may be useful tools to assess HS with complex perianal fistulas, but the iconographic patterns of hidradenitis and Crohn’s disease should be kept in mind as both may be associated.
{"title":"Severe perineal hidradenitis suppurativa (HS) and anal fistulas. An underrated association","authors":"J. C. Bernal-Sprekelsen, L. Romero, J. Soriano, J. Plá, G. Cortés, A. Abellán","doi":"10.30476/ACRR.2020.46748","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46748","url":null,"abstract":"Abstract Background Due to its multiple forms of debut hidradenitis suppurativa has classically been a diagnostic challenge as well in the differential diagnosis. Prevalence of perianal fistula in patients with hidradenitis suppurativa ranges form 6,6% to 67%. The aim of the study was to assess both conditions. Methods A retrospective chart review from 2000 to 2018 using the ICD-9-CM, coded with 705.83. for patients with hidradenitis suppurativa was conducted. Hurley’s three stage classification was applied. Diagnosis and relevant patient characteristics were assessed and the presence of associated perianal fistula. Endoa-nal ultrasound (EAU) was performed in 61% of the patients with perianal hidradenitis and perianal fistu-la, and magnetic resonance imaging (MRI) in 19%. Results Of 143 cases with hidradenitis, sixty two cases (43,4%) presented perianal (perineal/buttocks) location. Of them 93,5% were men. Twenty-one percent were associated with perianal fistulas being 6 of them complex ones associated with Hurley stage II and III. Treatment for the latter included: loose setons in 4 patients with Crohn’s disease and in 2 non Crohn’s disease with complex fistulas, 4 fistulotomies and 2 fistulectomies in low transphincteric fistulas and 1 with incision and drainage. Conclusion Perianal fistula should be treated according to associated diseases and type of fistula. Association of hidradenitis and perianal fistulas may be higher than expected and the relation of severe hidradenitis with complex perianal fistulas should be studied further. Endoanal ultrasound and MRI may be useful tools to assess HS with complex perianal fistulas, but the iconographic patterns of hidradenitis and Crohn’s disease should be kept in mind as both may be associated.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"24 1","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75940073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.30476/ACRR.2020.46564
I. Shahramian, B. Behi, Mehrdad Salahifar, Ali Mirabbasi
There are few reports on the therapeutic role of colonoscopy in correcting intussusception of childhood. In the present report, 15 children (14 boys and 1 girl) presented with acute intussusception and successfully treated by colonoscopy were presented. The patients were referred to the gastroenterology clinic of Ami-Al-Momenin Hospital, Zabol, Iran from 2015 to 2018. The mean age of the patients was 36.6±28.7 months. After stablishing the diagnosis, they underwent colonoscopic reduction of intussusception by an experienced gastroenterologist. Following 24 hours of the procedure, follow up sonography was performed. Overall, 6 recurrences were identified in 4 (26.7%) patients which were managed by a second colonoscopy. A second recurrence was detected in two patients who finally underwent surgical reduction. Regarding the role of colonoscopy in providing a visual and real-time setting, this can be used as either a primary option or an alternative to radiologic and surgical procedures of intussusception reduction in children.
{"title":"Colonoscopy-Assisted Resolving of Intussusception in Children, a Report of 15 Cases","authors":"I. Shahramian, B. Behi, Mehrdad Salahifar, Ali Mirabbasi","doi":"10.30476/ACRR.2020.46564","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46564","url":null,"abstract":"There are few reports on the therapeutic role of colonoscopy in correcting intussusception of childhood. In the present report, 15 children (14 boys and 1 girl) presented with acute intussusception and successfully treated by colonoscopy were presented. The patients were referred to the gastroenterology clinic of Ami-Al-Momenin Hospital, Zabol, Iran from 2015 to 2018. The mean age of the patients was 36.6±28.7 months. After stablishing the diagnosis, they underwent colonoscopic reduction of intussusception by an experienced gastroenterologist. Following 24 hours of the procedure, follow up sonography was performed. Overall, 6 recurrences were identified in 4 (26.7%) patients which were managed by a second colonoscopy. A second recurrence was detected in two patients who finally underwent surgical reduction. Regarding the role of colonoscopy in providing a visual and real-time setting, this can be used as either a primary option or an alternative to radiologic and surgical procedures of intussusception reduction in children.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"61 1","pages":"33-36"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84915353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.30476/ACRR.2020.46475
G. V. Pelt, R. Tollenaar, W. Mesker
Determining the tumor-stroma ratio (TSR) using a conventional microscope is an easy to apply and highly reproducible method. Due to digitalization in the pathology workflow, the demand for automated analysis of the TSR method is rising. However, the process of automation is rather time consuming and needs validation before implementation in daily practice. In addition, international studies ask for exchange of digital images instead of the actual slides. This calls for an alternative digital scoring method. This brief report describes the pitfalls of analyzing the TSR using digital images and proposes essential adaptations to create a standardized and reproducible scoring protocol. By using a circular annotation to mimic the microscopic method, these pitfalls can be avoided. Scoring the TSR digitally using a circular annotation does not take much additional effort compared to the microscopic method. When a fixed size of the annotation is saved, new cases can be scored in less than two minutes. With this brief report we propose an adjusted method for scoring the TSR on digital images to fill the gap between microscopically and automated scoring of the TSR. In addition, it opens the opportunity for application in daily diagnostics.
{"title":"Filling the gap between microscopic and automated analysis of the tumor-stroma ratio","authors":"G. V. Pelt, R. Tollenaar, W. Mesker","doi":"10.30476/ACRR.2020.46475","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46475","url":null,"abstract":"Determining the tumor-stroma ratio (TSR) using a conventional microscope is an easy to apply and highly reproducible method. Due to digitalization in the pathology workflow, the demand for automated analysis of the TSR method is rising. However, the process of automation is rather time consuming and needs validation before implementation in daily practice. In addition, international studies ask for exchange of digital images instead of the actual slides. This calls for an alternative digital scoring method. This brief report describes the pitfalls of analyzing the TSR using digital images and proposes essential adaptations to create a standardized and reproducible scoring protocol. By using a circular annotation to mimic the microscopic method, these pitfalls can be avoided. Scoring the TSR digitally using a circular annotation does not take much additional effort compared to the microscopic method. When a fixed size of the annotation is saved, new cases can be scored in less than two minutes. With this brief report we propose an adjusted method for scoring the TSR on digital images to fill the gap between microscopically and automated scoring of the TSR. In addition, it opens the opportunity for application in daily diagnostics.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"85 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89861433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.30476/ACRR.2020.46473
A. Jafari, M. Moazeni, S. Hosseini, H. Khazraei, S. Nematolahi, S. M. Tadayon
Abstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect of long-term consumption of Z. multiflora EO on hematological and biochemical parameters in patients infected with liver hydatid disease. Materials and Methods: Fifteen patients were administered orally with Z. multiflora EO (60 mg daily) for six months. Hematological and biochemical analysis were performed on the blood samples of patients before the start of treatment and after completion of the treatment course. In hematological analysis, WBC, RBC, Hb, hematocrit, MCV, MCH, MCHC and platelets were measured. In biochemical analysis, FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, K, Cl, AST, ALT, and ALK were assessed. Results: No apparent changes were observed in the values of hematological parameters of the patients after treatment. No significant changes also occurred in the values of FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, and K. The mean values of AST, ALT and ALK enzymes decreased significantly after treatment (P ˂ 0.05). No adverse clinical event was noticed in the patients during the course of study. Conclusions: Long-term consumption of Z. multiflora EO induced no adverse effect on the hematological and biochemical parameters of patients infected with liver hydatid disease. Since Z. multiflora EO reduced the level of liver transaminases (AST, ALT and ALK), this herbal product may be considered as a hepatoprotective agent in human beings.
{"title":"Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease","authors":"A. Jafari, M. Moazeni, S. Hosseini, H. Khazraei, S. Nematolahi, S. M. Tadayon","doi":"10.30476/ACRR.2020.46473","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46473","url":null,"abstract":"Abstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect of long-term consumption of Z. multiflora EO on hematological and biochemical parameters in patients infected with liver hydatid disease. Materials and Methods: Fifteen patients were administered orally with Z. multiflora EO (60 mg daily) for six months. Hematological and biochemical analysis were performed on the blood samples of patients before the start of treatment and after completion of the treatment course. In hematological analysis, WBC, RBC, Hb, hematocrit, MCV, MCH, MCHC and platelets were measured. In biochemical analysis, FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, K, Cl, AST, ALT, and ALK were assessed. Results: No apparent changes were observed in the values of hematological parameters of the patients after treatment. No significant changes also occurred in the values of FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, and K. The mean values of AST, ALT and ALK enzymes decreased significantly after treatment (P ˂ 0.05). No adverse clinical event was noticed in the patients during the course of study. Conclusions: Long-term consumption of Z. multiflora EO induced no adverse effect on the hematological and biochemical parameters of patients infected with liver hydatid disease. Since Z. multiflora EO reduced the level of liver transaminases (AST, ALT and ALK), this herbal product may be considered as a hepatoprotective agent in human beings.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"78 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91310162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.30476/ACRR.2020.46537
M. Rezazadehkermani
I review the interesting article “Effects of Platelet-Rich Plasma on Healing of Sphincteroplasty: An Experiment in Rabbit Model” (1)about application of Platelet-Rich Plasma in the anal sphincteroplasty While reviewing the article which proposed a novel idea for improving the outcome of sphincteroplasty three issues were questionable for me: The first issue is the site of sphincterotomy as it is mentioned located in posterior midline. It is known that the external anal sphincter is connected posteriorly to the anococcygeal ligament posteriorly (2) and division of sphincter in this point is not always associated with separation of sphincter and fecal incontinence. Animal experiments on the anal sphincter is different in the basis of sphincter function rather than an anatomical basis has a physiologic basis and if sphincterotomy is done in an animal the impaired function should be demonstrated(3) before further intervention. Due to small size of sphincter complex in the small animals it is sometimes hard to understand the exact territory of muscle.
{"title":"Platelet-Rich Plasma in Sphincteroplasty","authors":"M. Rezazadehkermani","doi":"10.30476/ACRR.2020.46537","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46537","url":null,"abstract":"I review the interesting article “Effects of Platelet-Rich Plasma on Healing of Sphincteroplasty: An Experiment in Rabbit Model” (1)about application of Platelet-Rich Plasma in the anal sphincteroplasty While reviewing the article which proposed a novel idea for improving the outcome of sphincteroplasty three issues were questionable for me: The first issue is the site of sphincterotomy as it is mentioned located in posterior midline. It is known that the external anal sphincter is connected posteriorly to the anococcygeal ligament posteriorly (2) and division of sphincter in this point is not always associated with separation of sphincter and fecal incontinence. Animal experiments on the anal sphincter is different in the basis of sphincter function rather than an anatomical basis has a physiologic basis and if sphincterotomy is done in an animal the impaired function should be demonstrated(3) before further intervention. Due to small size of sphincter complex in the small animals it is sometimes hard to understand the exact territory of muscle.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"16 1","pages":"40-40"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87815689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.30476/ACRR.2020.46438
S. Sarvepalli, P. Lal, Afrin N. Kamal, A. Garber, J. McMichael, G. Morris-Stiff, J. Vargo, M. Rothberg, Maged Rizk, C. Burke
Determining the tumor-stroma ratio (TSR) using a conventional microscope is an easy to apply and highly reproducible method. Due to digitalization in the pathology workflow, the demand for automated analysis of the TSR method is rising. However, the process of automation is rather time consuming and needs validation before implementation in daily practice. In addition, international studies ask for exchange of digital images instead of the actual slides. This calls for an alternative digital scoring method. This brief report describes the pitfalls of analyzing the TSR using digital images and proposes essential adaptations to create a standardized and reproducible scoring protocol. By using a circular annotation to mimic the microscopic method, these pitfalls can be avoided. Scoring the TSR digitally using a circular annotation does not take much additional effort compared to the microscopic method. When a fixed size of the annotation is saved, new cases can be scored in less than two minutes. With this brief report we propose an adjusted method for scoring the TSR on digital images to fill the gap between microscopically and automated scoring of the TSR. In addition, it opens the opportunity for application in daily diagnostics.
{"title":"Filling the gap between microscopic and automated analysis of the tumor-stroma ratio","authors":"S. Sarvepalli, P. Lal, Afrin N. Kamal, A. Garber, J. McMichael, G. Morris-Stiff, J. Vargo, M. Rothberg, Maged Rizk, C. Burke","doi":"10.30476/ACRR.2020.46438","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46438","url":null,"abstract":"Determining the tumor-stroma ratio (TSR) using a conventional microscope is an easy to apply and highly reproducible method. Due to digitalization in the pathology workflow, the demand for automated analysis of the TSR method is rising. However, the process of automation is rather time consuming and needs validation before implementation in daily practice. In addition, international studies ask for exchange of digital images instead of the actual slides. This calls for an alternative digital scoring method. This brief report describes the pitfalls of analyzing the TSR using digital images and proposes essential adaptations to create a standardized and reproducible scoring protocol. By using a circular annotation to mimic the microscopic method, these pitfalls can be avoided. Scoring the TSR digitally using a circular annotation does not take much additional effort compared to the microscopic method. When a fixed size of the annotation is saved, new cases can be scored in less than two minutes. With this brief report we propose an adjusted method for scoring the TSR on digital images to fill the gap between microscopically and automated scoring of the TSR. In addition, it opens the opportunity for application in daily diagnostics.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"19 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82899025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.30476/ACRR.2020.46494
M. Pol
Background: Success of laparoscopic cholecystectomy depends on multiple factors.Knowledge about altered anatomy, physiology and pathology of gall bladder, and thesurgeons experience in applying different surgical technique during difficult cholecystectomyare collectively important for a safe outcome.Methods: A total data of 875 patients who underwent cholecystectomy were analysed from June 2014 to May 2019. Study was mainly focused on looking for various intraoperative findings that could be the reason for conversion to open cholecystectomy in patients with difficult anatomy, physiology and pathology associated gall stone disease.Results: about 279/875 (31.9%) had difficult gall bladder with altered anatomy and pathology. Overall, conversion rate among difficult laparoscopic cholecystectomy was 62/279 (22.2%). 36/875 (2.4%) patients undergone subtotal cholecystectomy. 1/875 (0.1%)had common bile duct injury underwent repair. 54/875 (61.7%) had developed overall complications and 1/875 (0.1%) died due sepsis.Conclusion: High conversion rate and complications are seen in patients with contracted gallbladder and adhesions due to previous intervention. Conversion from laparoscopic cholecystectomy to open cholecystectomy is not a complication but continuum of treatment to reduce morbidity. Use of the critical view of safety technique very useful.
{"title":"The effect of various surgical techniques in difficult cholecystectomy: A retrospective cohort study","authors":"M. Pol","doi":"10.30476/ACRR.2020.46494","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46494","url":null,"abstract":"Background: Success of laparoscopic cholecystectomy depends on multiple factors.Knowledge about altered anatomy, physiology and pathology of gall bladder, and thesurgeons experience in applying different surgical technique during difficult cholecystectomyare collectively important for a safe outcome.Methods: A total data of 875 patients who underwent cholecystectomy were analysed from June 2014 to May 2019. Study was mainly focused on looking for various intraoperative findings that could be the reason for conversion to open cholecystectomy in patients with difficult anatomy, physiology and pathology associated gall stone disease.Results: about 279/875 (31.9%) had difficult gall bladder with altered anatomy and pathology. Overall, conversion rate among difficult laparoscopic cholecystectomy was 62/279 (22.2%). 36/875 (2.4%) patients undergone subtotal cholecystectomy. 1/875 (0.1%)had common bile duct injury underwent repair. 54/875 (61.7%) had developed overall complications and 1/875 (0.1%) died due sepsis.Conclusion: High conversion rate and complications are seen in patients with contracted gallbladder and adhesions due to previous intervention. Conversion from laparoscopic cholecystectomy to open cholecystectomy is not a complication but continuum of treatment to reduce morbidity. Use of the critical view of safety technique very useful.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"15 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73608815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.30476/ACRR.2020.46611
Vidyachandra Gandhi, N. Rayate, Satish Pattanshetti, P. Gautam
We report a rare variant of mucocele of the appendix. An elderly gentleman was admitted with symptoms and signs of acute appendicitis. He underwent laparoscopic converted open appendicectomy. On exploration there were pearls or fish egg like globular material along with jelly in and around the appendix. On examination of the specimen a differential diagnosis of hydatid cyst or pseudomyxoma was considered. On microscopic examination, the globules consisted of eosinophilic laminations of mucin surrounding an amorphous granular core. After histopathological examination, our case was diagnosed as myxoglobulosis of the appendix.Acute appendicitis is a common clinical problem and appendisectomy a regular surgery. The clinician should be aware of this entity of myxoglobulosis, to avoid confusion with pseudomyxoma or hydatid cyst. Presence of typical fish eggs or pearls like globular structures in and around the appendix is suggestive of myxoglobulosis. Appendisectomy is curative treatment for patients with myxoglobulosis of appendix and there are no reports of its recurrence.
{"title":"Pearls in the appendix (Myxoglobulosis) : a case report","authors":"Vidyachandra Gandhi, N. Rayate, Satish Pattanshetti, P. Gautam","doi":"10.30476/ACRR.2020.46611","DOIUrl":"https://doi.org/10.30476/ACRR.2020.46611","url":null,"abstract":"We report a rare variant of mucocele of the appendix. An elderly gentleman was admitted with symptoms and signs of acute appendicitis. He underwent laparoscopic converted open appendicectomy. On exploration there were pearls or fish egg like globular material along with jelly in and around the appendix. On examination of the specimen a differential diagnosis of hydatid cyst or pseudomyxoma was considered. On microscopic examination, the globules consisted of eosinophilic laminations of mucin surrounding an amorphous granular core. After histopathological examination, our case was diagnosed as myxoglobulosis of the appendix.Acute appendicitis is a common clinical problem and appendisectomy a regular surgery. The clinician should be aware of this entity of myxoglobulosis, to avoid confusion with pseudomyxoma or hydatid cyst. Presence of typical fish eggs or pearls like globular structures in and around the appendix is suggestive of myxoglobulosis. Appendisectomy is curative treatment for patients with myxoglobulosis of appendix and there are no reports of its recurrence.","PeriodicalId":8370,"journal":{"name":"Annals of Colorectal Research","volume":"1 1","pages":"37-39"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77594882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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