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Doxorubicin nephrotoxicity in cats (Felis catus) with malignant mammary neoplasms 阿霉素对患有恶性乳腺肿瘤的猫的肾毒性
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12860
M. M. Nogueira, G. Lavalle, A. Botelho, J. Veado, G. Cassali, P. Paes, M. M. Melo
ABSTRACT The aim of the study was to investigate the nephrotoxicity of doxorubicin in cats with malignant neoplasms of the mammary gland. All selected cats did not present comorbidities such as nephropathies and/or cardiomyopathies, confirmed by physical and laboratory tests, underwent radical mastectomy associated with regional lymph node excision and were treated with a protocol based on doxorubicin. Renal markers of urea, creatinine, symmetrical dimethylarginine were evaluated during all the treatment, and two months after the end. Abdominal ultrasound, urinalysis and biochemical analysis of protein, urinary creatinine and urinary GGT were performed in the beginning and two months after the end of the treatment, to evaluate possible renal alterations. Six cats did not present renal alterations in any exams performed during the study. Two cats presented azotemia during this study, and one of them stopped the treatment early, because of the intense azotemia. Clinical imaging and laboratory monitoring of patients throughout the treatment is essential, including the measurement of analytes that detect kidney changes early. Thus, it is emphasized that doxorubicin is a safe drug for use in non-nephropathic cats.
摘要本研究的目的是研究阿霉素对乳腺恶性肿瘤猫的肾毒性。所有入选的猫均未出现合并症,如经物理和实验室检查证实的肾病和/或心肌病,接受了根治性乳房切除术并伴有局部淋巴结切除,并接受了基于阿霉素的治疗方案。在治疗期间及治疗结束后2个月评估肾脏指标尿素、肌酐、对称二甲基精氨酸。在治疗开始及治疗结束后2个月分别行腹部超声、尿液分析及生化分析蛋白、尿肌酐、尿GGT,评估可能的肾脏改变。在研究期间进行的任何检查中,有6只猫没有出现肾脏改变。在这项研究中,两只猫出现了氮质血症,其中一只因为氮质血症严重而提前停止了治疗。在整个治疗过程中对患者进行临床成像和实验室监测是必不可少的,包括检测早期肾脏变化的分析物。因此,强调阿霉素是一种安全的药物,用于非肾病猫。
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引用次数: 0
Influence of oral health on the facial expressions and on the acupuncture examination in equines 口腔健康对马面部表情及针刺检查的影响
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12678
ABSTRACT The present study investigated the influence of oral health on horses’ facial expression, reactivity of the acupuncture points and the perception of trainers and owners. We investigated 87 adult horses involved in sports or working activities. Pain was scored in person and by photography by an evaluator “blinded” to the animals’ dental condition, using the Horse Grimace Scale (HGS). The acupuncture examination was performed by the same evaluator. Animals were evaluated before (T0) and 15 days (T1) after dental treatment. All horses included in the study had dental disorders. Statistically significant results were seen in median HGS scoring (3 vs. 1, p = 0.001) and number of reactive acupoints (11.2±5.6 vs. 4±2.9, p = 0.001). Additionally, complaints by the trainers/owners were lower at T1 compared with T0. There was a reduction in the pain reaction to application of pressure on following acupoints: dental point (44 vs. 4), Stomach-7 (31 vs. 3), Tiple-Heater (TH)-17 (27 vs. 4), and TH-16 (22 vs. 4). We concluded that acupuncture can be an adjunct method for diagnosis of dental disorders and treatment follow-up.
摘要本研究调查了口腔健康对马面部表情、穴位反应性以及驯马师和主人感知的影响。我们调查了87匹参与体育或工作活动的成年马。疼痛由一名对动物的牙齿状况“视而不见”的评估人员亲自和通过摄影进行评分,并使用马痛苦量表(HGS)。针灸检查由同一评估人员进行。在牙齿治疗前(T0)和治疗后15天(T1)对动物进行评估。研究中所有的马都患有牙齿疾病。HGS评分中位数(3 vs.1,p=0.001)和反应穴位数量(11.2±5.6 vs.4±2.9,p=0.001)具有统计学意义。此外,与T0相比,训练者/所有者在T1的投诉较低。对以下穴位施加压力的疼痛反应有所减轻:牙穴(44对4)、胃-7(31对3)、提普加热器(TH)-17(27对4)和TH-16(22对4)。我们得出的结论是,针灸可以作为诊断牙齿疾病和随访治疗的辅助方法。
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引用次数: 0
Prediction of health disorders in dairy cows monitored with collar based on Binary logistic analysis 基于二元logistic分析的颈圈监测奶牛健康障碍预测
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12880
ABSTRACT The objective of this study was to analyze data on physical activity and rumination time monitored via collars at the farm coupled with milk yield recorded by the rotary milking system to predict cows based on several disorders using the binary Logistic regression conducted with R software. Data for metritis (n=60), mastitis (n=98), lameness (n=35), and digestive disorders (n=52) were collected from 1,618 healthy cows used to construct the prediction model. To verify the feasibility and adaptability of the proposed method, we analyzed data of cows in the same herd (herd 1) not used to construct the model, and cows in another herd (herd 2) with data recorded by the same type of automated system, and led to detection of 75.0%, 64.2%, 74.2%, and 76.9% animals in herd 1 correctly predicted to suffer from metritis, mastitis, lameness, and digestive disorders, respectively. For cows in herd 2, 66.6%, 58.8%, 80.7%, and 71.4% were correctly predicted for metritis, mastitis, lameness, and digestive disorders, respectively. Compared with traditional clinical diagnoses by farm personnel, the algorithm developed allowed for earlier prediction of cows with a disorder.
摘要本研究的目的是利用R软件进行二元Logistic回归,分析农场项圈监测的身体活动和反刍时间数据,以及旋转挤奶系统记录的产奶量,以预测奶牛的几种疾病。收集1,618头健康奶牛的体炎(n=60)、乳腺炎(n=98)、跛行(n=35)和消化系统疾病(n=52)数据,用于构建预测模型。为了验证该方法的可行性和适应性,我们分析了未用于构建模型的同一畜群(畜群1)的奶牛数据,以及同一类型自动化系统记录的另一畜群(畜群2)的奶牛数据,结果表明,畜群1中分别有75.0%、64.2%、74.2%和76.9%的奶牛被正确预测患有胎炎、乳腺炎、跛行和消化系统疾病。在2头奶牛中,子宫炎、乳腺炎、跛行和消化系统疾病的预测正确率分别为66.6%、58.8%、80.7%和71.4%。与农场工作人员的传统临床诊断相比,开发的算法可以更早地预测奶牛的疾病。
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引用次数: 0
Exogenous amylase increases gas production and improves in vitro ruminal digestion kinetics of sorghum and corn grains 外源淀粉酶增加了高粱和玉米谷物的产气量并改善了体外瘤胃消化动力学
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12803
ABSTRACT The aim of this study was to evaluate the effect of exogenous amylase on gas production, in vitro dry matter digestibility (IVDMD), and in vitro digestion kinetics of sorghum (Sorghum vulgaris) and two corn hybrids of different grain textures. Ruminal fluid was collected from two rumen-fistulated cows receiving or not exogenous amylase (0.7g kg-1 of dry matter (DM basis)), provided to achieve 396 kilo Novo units kg-1 for amylase activity (DM basis). Gas production was measured after 1, 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42 e 48 hours of incubation. Amylase increased gas production (mL) by 5.4%. Corn hybrids have higher in vitro dry matter digestibility than sorghum. Exogenous amylase increased the potential of gas production (A) (P=0.01). There was an effect of hybrid for IVDMD (P<0.01). The addition of exogenous amylase increases the in vitro gas production, improves fermentation kinetics, and increases the production of the ammonia nitrogen of corn and sorghum grains, but does not affect in vitro and dry matter digestibility or the short-chain fatty acids production.
摘要本研究旨在评估外源淀粉酶对高粱(sorghum vulgaris)和两个不同质地玉米杂交种的产气、体外干物质消化率(IVDMD)和体外消化动力学的影响。从接受或不接受外源淀粉酶(0.7g kg-1干物质(DM基))的两头瘤胃造瘘奶牛中收集瘤胃液,以达到396公斤Novo单位kg-1的淀粉酶活性(DM基。在培养1、3、6、9、12、15、18、21、24、30、36、42 e 48小时后测量气体产量。淀粉酶使产气量(mL)增加5.4%。玉米杂交种的体外干物质消化率高于高粱。外源淀粉酶增加了产气潜力(A)(P=0.01)。IVDMD存在杂交效应(P<0.01)。外源淀粉酶的加入增加了体外产气,改善了发酵动力学,增加了玉米和高粱籽粒的氨氮产量,但不影响体外和干物质的消化率或短链脂肪酸的产生。
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引用次数: 1
Surgical removal of periocular neoformation in Peixe -Kinguiu (Carassius Auratus) submitted to anesthesia with propofol in combination with morphine - case report 丙泊酚复合吗啡麻醉下应用手术切除金桂鱼眼周新生血管1例
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12676
M. Rorig, J. R. Garcez, L. A. Baumgartner, M. R. Matos, M. Wilmsen, S.U. Cardoso, S. D. Silveira, R. A. Bombardelli
ABSTRACT Different anesthetic agents are commonly used during procedures performed in aquaculture to minimize stress and maximize fish welfare during handling. A Kinguio fish was treated with a history of a mass near the left eye. In the clinical evaluation, a pedunculated neoformation was found in the periocular region. The fish was submitted to anesthesia for surgical removal of the mass, which was later referred to histopathological evaluation, revealing myxoma. The anesthesia protocol used 1% propofol at a concentration of 5 mg/liter of water and morphine at a dose of 5 mg/kg, intramuscularly. Immediately after the end of the procedure, the fish was returned to the aquarium and its anesthetic recovery was observed. The objective of this report is to describe a surgical procedure in kinguio fish and to determine the efficacy of propofol associated with morphine in this species. As a result, complete immobilization of the fish was obtained with propofol, reaching the fourth stage of anesthesia and the administration of morphine suggested being able to provide effective and long-lasting analgesia. It is concluded that despite the positive results obtained, anesthesia in fish still needs to be extensively investigated to refine analgesia protocols during procedures that cause pain and stress.
摘要水产养殖过程中通常使用不同的麻醉剂,以最大限度地减少处理过程中的压力并最大限度地提高鱼类的福利。一条金桂鱼因左眼附近有肿块病史而接受治疗。在临床评估中,在眼周区域发现有带蒂新生血管。将该鱼进行麻醉以手术切除肿块,随后进行组织病理学评估,发现粘液瘤。麻醉方案使用浓度为5mg/l水的1%丙泊酚和剂量为5mg/kg的吗啡,肌肉注射。手术结束后,立即将鱼送回水族馆,观察其麻醉恢复情况。本报告的目的是描述金龟鱼的手术过程,并确定丙泊酚与吗啡联合使用对该物种的疗效。结果,丙泊酚使鱼完全固定,达到麻醉的第四阶段,吗啡的给药表明能够提供有效和持久的镇痛。结论是,尽管取得了积极的结果,但在导致疼痛和压力的手术中,鱼类的麻醉仍需广泛研究,以完善镇痛方案。
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引用次数: 0
Temporary hyperpigmentation as a complication of fixing the freestyle libre sensor in a cat - a case report 在猫身上固定自由式自由传感器引起的暂时性色素沉着-一例报告
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12896
ABSTRACT This report described temporary hyperpigmentation occurring in a cat after use of the FreeStyle® Libre sensor by applying three different adhesive glues. The device was continuously used as an aid for the treatment of diabetes mellitus. Histopathological examination revealed mild focal chronic active dermatitis. While the coat color change occurred due to inflammation and did not affect the device functioning, owners should be alerted to the possibility of this complication.
摘要:本报告描述了在使用FreeStyle®Libre传感器后,通过使用三种不同的粘合剂在猫身上发生的暂时性色素沉着。该装置一直被用作治疗糖尿病的辅助手段。组织病理学检查显示轻度局灶性慢性活动性皮炎。虽然皮毛颜色的变化是由于炎症引起的,并不影响设备的功能,但主人应该警惕这种并发症的可能性。
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引用次数: 0
Effects of time-dependent degradation and freezing on biomechanical properties of healthy bovine jejunum 时间依赖性降解和冷冻对健康牛空肠生物力学特性的影响
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12895
ABSTRACT Degradation of bovine small intestine and respective effects on biomechanics have not been described to date. Biomechanical testing of intestinal tissues is often carried out within a few hours of donor death and tissue deterioration is not accounted for. Freezing is efficient for the preservation of several tissues; however, it may cause cellular damage. This study investigated the morphologic and biomechanical changes of bovine jejunum at different postmortem moments. Effects of freezing and thawing on morphology and biomechanical behavior were also examined. Macroscopic changes were first noted within eight hours of death. At this time, histologic changes also started to set in, and biomechanical tests revealed lower bursting pressure (203.10±46.14mmHg). At 12 hours, tissue rearrangement was noted, and bursting pressure increased (238.43±31.04mmHg). A second drop in pressure was detected at 18 hours (235.20±38.21mmHg), followed by a progressive drop until the end of the experimental period. Histologic changes revealed progressive deterioration. Mechanical resistance did not differ between thawed and fresh specimens. It was concluded that bovine jejunal specimens retain biomechanical resistance up to 6 hours after death. Freezing and thawing did not affect the mechanical resistance of the intestinal wall in this experimental model.
到目前为止,牛小肠的降解及其对生物力学的影响尚未得到描述。肠组织的生物力学测试通常在供体死亡后的几个小时内进行,并且不考虑组织退化。冷冻对保存几种组织是有效的;然而,它可能会导致细胞损伤。本研究观察了不同死后时刻牛空肠的形态和生物力学变化。冷冻和解冻对形态和生物力学行为的影响也进行了研究。死亡后8小时内首次发现宏观变化。此时,组织学变化也开始出现,生物力学测试显示爆裂压力较低(203.10±46.14mmHg)。12小时时,发现组织重排,爆裂压力增加(238.43±31.04mmHg);18小时时,压力再次下降(235.20±38.21mmHg),随后逐渐下降,直到实验期结束。组织学变化显示逐渐恶化。解冻标本和新鲜标本的机械阻力没有差异。得出的结论是,牛空肠标本在死亡后6小时内仍保持生物力学阻力。在该实验模型中,冷冻和解冻不影响肠壁的机械阻力。
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引用次数: 0
Morphometric analysis on erythrocytes of various livestock being reared in the Cholistan desert 不同家畜红细胞形态计量学分析
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12767
ABSTRACT The present study aimed to assess the influence of physiological exposure to erythrocyte indices; the morphometric parameters of the size of erythrocytes, as well as synergistic effects on the erythrocyte spectrum changes in various species being reared in different strip-wasteland conditions. We collected samples from 400 animals from the jugular veins and made 2000 blood smears, sample blood was taken by an expert veterinary doctor and transferred into an EDTA vacutainer. Blood smears were stained through the Pappenheim procedure and slides were photomicrographed under 100x objective. The parameters of morphometry of erythrocytes were largest in cattle after buffalo, sheep, while goats have the lowest one. The influence of age was significant p<0.05. The influence of sex was not significant in Cattle p<0.01, values of a parameter of erythrocytes were higher in young than in adults in sheep, goats, cattle, and buffalo. The size of erythrocytes in males was higher than females in sheep, goat, and buffalo but in cattle values of female erythrocytes were higher than in males. Further, gender, altitude, and age have a profound influence on the morphometric attributes of erythrocytes. It will be helpful in interpreting etiopathogenetic conditions in human beings and other animals.
摘要本研究旨在评估生理暴露对红细胞指数的影响;红细胞大小的形态计量参数,以及在不同条带荒地条件下饲养的不同物种对红细胞光谱变化的协同效应。我们从400只动物的颈静脉采集了样本,并进行了2000次血液涂片,由专业兽医采集血液样本,并将其转移到EDTA真空罐中。通过Pappenheim程序对血涂片进行染色,并在100倍物镜下对载玻片进行显微照相。牛红细胞形态计量学参数最大,仅次于水牛、绵羊,山羊最低。年龄的影响有统计学意义(p<0.05)。性别对牛的影响不显著,p<0.01,绵羊、山羊、牛和水牛的幼崽红细胞参数值高于成年个体。绵羊、山羊和水牛的雄性红细胞大小高于雌性,但牛的雌性红细胞值高于雄性。此外,性别、海拔高度和年龄对红细胞的形态计量特性有着深远的影响。这将有助于解释人类和其他动物的发病条件。
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引用次数: 0
Performance and feed preference of weaned piglets fed with corn grain silage subjected to different rehydration sources 不同复水来源对玉米青贮断奶仔猪生产性能及饲料偏好的影响
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12812
ABSTRACT The objective of this study was to evaluate the effects of diets composed of corn grain silage rehydrated with water and acid whey on the productive performance and feed preference of weaned piglets. We evaluated 120 piglets weaned in the pre-initial phase I for productive performance, and diarrhea, depression, and thinness states using the following diets: control ration with dry corn grain (CR); and corn grain silage rehydrated with water (CGSR+W); water and inoculant (CGSR+WI); and acid whey (CGSR+AW). To determine feed preference, 20 weaned piglets received reference (CR) and test (CGSR+AW) diets in two phases, restricted and free-choice. Analysis of variance, chi-square test, and t-test were applied at 5% of significance. There were no differences (p>0.05) in growth performance among piglets fed the four experimental diets. Severe thinness and depression were recorded among piglets fed CGSR+W and CR (p<0.05). In the restricted phase, consumption of CGSR+AW resulted in higher daily feed intake (DFI) (p<0.05), while piglets in the free-choice phase showed a higher DFI and spent more time consuming CR, with a 56.39% preference (p<0.05). Rehydrated corn grain silage promoted feed acceptability and performance of piglets in the first weeks post-weaning.
摘要本研究的目的是评估玉米粒青贮饲料加水和酸乳清复水对断奶仔猪生产性能和饲料偏好的影响。我们使用以下日粮评估了120头在第一阶段断奶前断奶的仔猪的生产性能、腹泻、抑郁和消瘦状态:对照日粮为干玉米粒(CR);玉米青贮饲料(CGSR+W);水和接种剂(CGSR+WI);和酸性乳清(CGSR+AW)。为了确定饲料偏好,20头断奶仔猪接受参考(CR)和试验(CGSR+AW)日粮,分为限制和自由选择两个阶段。方差分析、卡方检验和t检验的显著性为5%。饲喂四种试验日粮的仔猪的生长性能没有差异(p>0.05)。饲喂CGSR+W和CR的仔猪出现严重的消瘦和抑郁症状(p<0.05)。在限制期,消耗CGSR+AW导致日采食量(DFI)增加(p<0.05),而自由选择期的仔猪表现出更高的DFI,消耗CR的时间更长,有56.39%的偏好(p<0.05)。在断奶后的第一周,重新水合的玉米粒青贮饲料提高了仔猪的饲料可接受性和生产性能。
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引用次数: 1
Anthelmintic resistance against gastrointestinal nematodes in beef cattle: effect on liveweight gain of grazing livestock in Mexico 肉牛对胃肠道线虫的抗药性:对墨西哥放牧牲畜增重的影响
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2023-06-01 DOI: 10.1590/1678-4162-12917
ABSTRACT This study aimed to determine the efficacy and parasite resistance of levamisole (LV) and ivermectin (IVM) in beef cattle naturally infected with gastrointestinal nematodes, as well as the effect on the liveweight gain in a tropical wet region of Oaxaca, Mexico. From November 2019 to January 2020, sixty-six grazing calves were randomly allocated into three groups of twenty-two animals each, treated with LV or IVM or an untreated control group (day 0). Feces were collected 1 day before treatment and 15 days after treatment. The liveweight gain from each animal was recorded at days 0, 15, 30 and 45 post treatment. The LV group presented the highest reduction of eggs per gram (EPG) of feces, followed by the IVM group. Resistance to IVM was detected, although LV resistance was also suspected. The IVM group had significantly higher effective treatment at 93.5%, resulting in an increase (P<0.05) of liveweight gain of 16.1kg, followed by the LV group (92.4%) with 17.1kg, compared to the untreated control group. A significant (P < 0.05) negative correlation was observed between EPG and weight gain for the LV (�� = -0.46) and IVM groups (�� = -0.32). LV and IVM showed a lack of efficacy against gastrointestinal nematodes, as well as an adequate capacity for EPG reduction but with IVM resistance and detrimental effects on growth performance in grazing beef cattle.
摘要本研究旨在确定左旋咪唑(LV)和伊维菌素(IVM)对天然感染胃肠道线虫的肉牛的疗效和寄生虫耐药性,以及对墨西哥瓦哈卡热带潮湿地区肉牛活重增加的影响。2019年11月至2020年1月,将66头放牧犊牛随机分为3组,每组22头,分别给予LV或IVM治疗和未治疗对照组(第0天),分别于治疗前1天和治疗后15天收集粪便。记录各组动物在处理后第0、15、30和45天的活重增重。LV组每克粪便减卵量最高,IVM组次之。检测到对IVM的耐药性,尽管也怀疑LV耐药性。IVM组的有效治疗率为93.5%,显著高于未治疗对照组(P<0.05),活重增加16.1kg (P<0.05),其次是LV组(92.4%),与未治疗对照组相比增加17.1kg。LV组(-0.46)和IVM组(-0.32)EPG与体重增加呈显著负相关(P < 0.05)。在放牧肉牛中,LV和IVM对胃肠道线虫缺乏抑制作用,对EPG有足够的抑制能力,但对IVM有抗性,对生长性能有不利影响。
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引用次数: 0
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