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Dose Analysis of BNCT Treatment Method for Rhabdomyosarcoma in the Head and Neck Regions Based on PHITS Code 基于PHITS代码的头颈部横纹肌肉瘤BNCT治疗方法的剂量分析
Q4 Environmental Science Pub Date : 2020-07-17 DOI: 10.29037/AJSTD.521
Dhani Nur Indra Syamputra, Y. Sardjono, Rida Siti Nur’aini Mahmudah
The objectives of this research were to ?nd (1) the optimum boron dose for treating rhab- domyosarcoma in the head and neck regions and (2) the effective irradiation time to treat rhab- domyosarcoma in the head and neck regions. This research used the particle and heavy ions transport code system (PHITS) to simulate the neutron source and BNCT doses. The neutron source used was Kartini Reactor. The simulation was carried out by creating the geometry of cancer tissue in the head and neck regions. Boron concentration variance was 30, 35, 40, 45, and 50 µg/g tissue. The output of PHITS was a neutron ?ux and neutron dose. The neutron ?ux value was used to acquire the alpha dose, proton dose, and gamma dose inside the tissue. The results showed that (1) the optimum boron dose for treating rhabdomyosarcoma in the head and neck regions was 50 µg/g tissue and (2) the effective irradiation time was 7 hours and 4 minutes, which was acquired with a boron concentration of 50 µg/g tissue. The higher the boron concentration level, the higher the dose rate, the quicker the irradiation time, and the lower the radiation dose received by healthy tissues.
这项研究的目的是?nd(1)治疗头颈部横纹肌肉瘤的最佳硼剂量;(2)治疗头颈区横纹肌肉瘤有效照射时间。本研究使用粒子和重离子传输编码系统(PHITS)来模拟中子源和BNCT剂量。使用的中子源是卡尔蒂尼反应堆。通过创建头部和颈部癌症组织的几何形状来进行模拟。硼浓度的变化分别为30、35、40、45和50µg/g组织。PHITS的输出是一个中子?ux和中子剂量。中子?ux值用于获取组织内的α剂量、质子剂量和γ剂量。结果表明:(1)治疗头颈部横纹肌肉瘤的最佳硼剂量为50µg/g组织;(2)有效照射时间为7小时4分钟,这是在硼浓度为50µg/g组织的情况下获得的。硼浓度水平越高,剂量率越高,照射时间越快,健康组织接受的辐射剂量越低。
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引用次数: 4
Boron Neutron Capture Therapy for Cancer: Future Prospects in Indonesia 癌症的硼中子俘获治疗:印度尼西亚的未来前景
Q4 Environmental Science Pub Date : 2020-07-17 DOI: 10.29037/AJSTD.510
Bagaswoto Poedjomartono, Hanif Afkari, E. Meiyanto, Alan Anderson Bangun, Y. Sardjono
Boron neutron capture therapy (BNCT) is a form of cancer therapy based on the interaction of low-energy thermal neutrons and boron-10 (10-B) to produce alpha radiation from He-4 and Li-7 with a high linear energy transfer. A beam of neutrons irradiates a boron drug injected into the tumor, resulting in the boron-injected cancer cells receiving a lethal dose of radiation with the surrounding, healthy cells being minimally affected. Two boron drugs have been used clinically in BNCT, boron sodium captate (BSH) and borophenylalanine (BPA), while a third, pentagamaboronon-0 (PGB-0), is currently under development in the Faculty of Pharmacy of Universitas Gadjah Mada, Indonesia. In Indonesia, there has been a growing interest in the study and use of BNCT to treat cancer, as this method is expected to be safer and more effective than traditional cancer treatment methods.
硼中子俘获疗法(BNCT)是癌症疗法的一种形式,基于低能热中子和硼-10(10-B)的相互作用,从He-4和Li-7产生具有高线性能量转移的α辐射。中子束照射注射到肿瘤中的硼药物,导致注射硼的癌症细胞接受致命剂量的辐射,周围的健康细胞受到的影响最小。两种硼药物,辛酸硼钠(BSH)和硼苯丙氨酸(BPA),已在BNCT临床上使用,而第三种药物,五gamaboronon-0(PGB-0),目前正在印度尼西亚加贾马达大学药学院开发中。在印度尼西亚,人们对BNCT治疗癌症的研究和使用越来越感兴趣,因为这种方法预计比传统的癌症治疗方法更安全、更有效。
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引用次数: 1
Marine Biofouling Communities of Manila South Harbor, Philippines 菲律宾马尼拉南港海洋生物污染群落
Q4 Environmental Science Pub Date : 2020-07-17 DOI: 10.29037/AJSTD.481
H. Nacorda, Nero M Austero, C. Pagdilao, K. Tan, R. Azanza
An immersion experiment was conducted in the Manila South Harbor to document the development of sessile biofouling communities. Test panels were submerged below the sea surface in April 2012 for short- (one and three months) and long-term (one year) exposures in seawater, then foauling types and occurrences were scored based on digital images of panel surfaces. The short-term immersed panels were found with significant cover of soft fouling (undet.), slime, and the invasive Balanus (=Amphibalanus) amphitrite. These also filled the long-term immersed panels, although some fell off due to mortality from crude oil smothering. Perna viridis, native but also invasive, successfully established and then dominated the fouling cover by the 12th month (April 2013). Oysters, bryozoans (Watersipora sp.), colonial tunicates, polychaetes (Hydroides sp.), and green algae contributed minor to fouling cover. These fouling communities in the Manila South Harbor consisted of organisms that were cosmopolitan in port waters of SE Asia. A similar study must be carried out in other major ports of the country and then compared.
在马尼拉南港进行了一项浸没实验,以记录固着生物污垢群落的发展。2012年4月,试板被淹没在海面下,在海水中进行短期(一个月和三个月)和长期(一年)暴露,然后根据试板表面的数字图像对起泡类型和发生情况进行评分。短期浸泡的面板上覆盖着大量的软结垢(未示出)、黏液和入侵性两栖纲动物。这些也填充了长期浸泡的面板,尽管有些面板由于原油窒息而脱落。天然但也具有侵袭性的绿脓杆菌在第12个月(2013年4月)成功建立并占据了污垢覆盖层的主导地位。牡蛎、苔藓虫(Watersipora sp.)、群落被膜动物、多毛类(Hydroides sp.)和绿藻对污染覆盖的贡献很小。马尼拉南港的这些污染群落由东南亚港口水域的国际化生物组成。必须在该国其他主要港口进行类似的研究,然后进行比较。
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引用次数: 2
Survey of Marine Phytoplankton in Ship’s Ballast Tanks at Laem Chabang International Port, Thailand 泰国莱姆查邦国际港船舶压载舱海洋浮游植物调查
Q4 Environmental Science Pub Date : 2020-07-17 DOI: 10.29037/AJSTD.484
S. Kajonwattanakul, Waranya Numnual, Thanyapas Sirichaiseth, Tanet Wannarangsri
Marine phytoplankton was investigated in ballast water of ships from 2010 to 2012 with a collection of 30 marine vessels that docked at Laem Chabang International Port in Chonburi Province, Thailand. The results showed that the dominant group of phytoplankton was diatoms. The amount of phytoplankton in the ballast tanks averaged less than 10 cells/ mL, which is less than Regulation D-2 of the Ballast Water Management Convention which requires that marine organisms between the sizes of 10 ? X <50 µm should be less than 10 cells/mL and size ? 50 µm should be less than 10 cell/m3 in ballast water. Alien species of phytoplankton was not recorded in this survey.
2010年至2012年,对停靠在泰国春武里省Laem Chabang国际港的30艘船只的压载水中的海洋浮游植物进行了调查。结果表明,浮游植物的优势类群为硅藻。压载舱中的浮游植物数量平均不到10个细胞/mL,低于《压载水管理公约》第D-2条,该条要求大小在10?X<50µm应小于10个细胞/mL,大小?压载水中的50µm应小于10 cell/m3。本次调查中没有记录到外来浮游植物物种。
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引用次数: 1
The invasive Caribbean Mytilopsis sallei (Bivalvia: Dreissenidae): A short review 入侵加勒比海沙蚤(双壳亚目:蚤科):综述
Q4 Environmental Science Pub Date : 2020-07-17 DOI: 10.29037/AJSTD.483
K. Tan, T. Tay
The mussel-like bivalve species from the Caribbean, Mytilopsis sallei, is now well established in the vicinities of several ports in South and Southeast Asia. Although it may not be as notorious as its relative the zebra mussel Dreissena polymorpha, this brackish-water bivalve has the ability to colonise and displace native species in intertidal and subtidal habitats. It is also another testament to how well a tropical species can travel beyond its natural biogeographical boundaries. Here we briefly review its taxonomy, morphology, growth and reproduction, habitat and distribution, as well as its impact on natural habitats after invasion, based on published literature.
来自加勒比海的类似贻贝的双壳类物种,Mytilopsis sallei,现在在南亚和东南亚的几个港口附近已经很成熟。尽管它可能不像它的亲戚斑马贻贝Dreissena polymorpha那样臭名昭著,但这种半咸水双壳类有能力在潮间带和潮下栖息地定居并取代本地物种。这也是热带物种能够很好地超越其自然生物地理边界的另一个证明。在此,我们根据已发表的文献,简要回顾了其分类学、形态、生长繁殖、栖息地和分布,以及入侵后对自然栖息地的影响。
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引用次数: 14
Characteristics of Paraffin Shielding of Kartini Reactor, Yogyakarta 日惹Kartini反应器的石蜡屏蔽特性
Q4 Environmental Science Pub Date : 2020-07-17 DOI: 10.29037/AJSTD.526
L. Khanifah, S. Widodo, Widarto, N. M. D. Putra, Argo Satrio
The National Nuclear Energy Agency (BATAN) Yogyakarta uses two kinds of paraffin for shielding radiation of Kartini reactor. For developing BNCT research, the radiation attenuation capability of paraffin has been analyzed to find out the coefficient attenuation, density, and composition of both kinds of paraffin. The components of the paraffin were analyzed using Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) spectroscopy characterization. Paraffin P1 has a density of 0.689 gr/mL and paraffin P2 is 0.578 gr/mL. Paraffin samples P1 and P2 were the sample content of functional group CH, CH2, and OH when analyzed by FTIR. Paraffin P2 had an additional content namely CO. The concentration of carbon (C) and oxide (O) of paraffin P2 was much greater than that of paraffin P1. Hydrogen (H) in the paraffin has the function of moderating neutrons, but hydrogen content in both kinds of paraffin could not be detected by EDX. The acquired neutron coefficient attenuation of paraffin P2 was 0.0382 cm-1 and the gamma coefficient attenuation was 0.0535 cm-1.
日惹国家核能机构(BATAN)使用两种石蜡来屏蔽Kartini反应堆的辐射。为了开展BNCT研究,分析了石蜡的辐射衰减能力,找出了两种石蜡的衰减系数、密度和组成。采用傅里叶变换红外光谱(FTIR)、扫描电镜(SEM)和能量色散x射线(EDX)光谱对石蜡的成分进行了分析。石蜡P1的密度为0.689 gr/mL,石蜡P2的密度为0.578 gr/mL。石蜡样品P1和P2为FTIR分析时官能团CH、CH2和OH的样品含量。石蜡P2含有CO,其碳(C)和氧化物(O)的浓度远大于石蜡P1。石蜡中的氢(H)具有中子的慢化功能,但两种石蜡中的氢含量都不能通过EDX检测到。得到的P2石蜡中子系数衰减为0.0382 cm-1,伽马系数衰减为0.0535 cm-1。
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引用次数: 5
Dose Analysis of Boron Neutron Capture Therapy (BNCT) Treatment for Lung Cancer Based on Particle and Heavy Ion Transport Code System (PHITS) 基于粒子和重离子输运编码系统(PHITS)的硼中子俘获治疗肺癌的剂量分析
Q4 Environmental Science Pub Date : 2020-07-17 DOI: 10.29037/AJSTD.545
A. Harish, Warsono, Y. Sardjono
The objectives of this study were to determine the effect of boron concentration on total dose rate for lung cancer treatment, and to determine the effect of boron concentration on the length of irradiation time for lung cancer treatment. This study was computer simulation-based using the Particle and Heavy Ion Transport code System (PHITS) by defining the geometry and components of lung cancer and the surrounding organism as the object being studied and the source of radiation used. The type of phantom used was the ORNL of an adult Asian male. The neutron source used was Kartini Reactor. The independent variable was the boron concentration of 30, 40, 50, 60, and 70 ?g/g cancer tissue and the dependent variables were the dose rate and the irradiation time. The results of this study indicated that the larger the amount of boron concentration that was injected, the higher the rate of total dose the organ received, where the total dose rate for each variation of boron concentration were 1.34 × 10-3 Gy/s, 1.71 × 10-3  Gy/s, 2.07 × 10-3 Gy/s, 2.42 × 10-3  Gy/s, and 2.78 × 10-3 Gy/s, and the larger the amount of boron concentration that was injected, the faster the irradiation time for the treatment of lung cancer was, where the irradiation time required for each variation of boron concentration was 37294 s, 29240 s, 24180 s, 20633 s, and 17996 s.
本研究的目的是确定硼浓度对肺癌治疗总剂量率的影响,以及硼浓度对肺癌治疗照射时间长短的影响。这项研究是基于计算机模拟的,使用粒子和重离子传输编码系统(PHITS),通过定义肺癌和周围生物体的几何形状和组成作为研究对象,并使用辐射源。使用的幻影类型是一名成年亚洲男性的ORNL。使用的中子源是Kartini反应堆。自变量为30、40、50、60、70 μ g/g癌组织硼浓度,因变量为剂量率和照射时间。这项研究的结果表明,注射的硼浓度越大,器官总剂量率越高,总剂量率为每一个变量的硼浓度分别为1.34×三分Gy /秒,1.71×三分Gy /秒,2.07×三分Gy /秒,2.42×三分Gy / s,和2.78×三分Gy / s,和大量的硼浓度越大,注入,照射时间越快治疗肺癌,其中,每种硼浓度变化所需的辐照时间分别为37294 s、29240 s、24180 s、20633 s和17996 s。
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引用次数: 3
GIS Developments for Ecosystem-based Marine Spatial Planning and the Challenges Faced in Indonesia 基于生态系统的海洋空间规划GIS发展与印尼面临的挑战
Q4 Environmental Science Pub Date : 2020-07-16 DOI: 10.29037/ajstd.587
K. Triana, A. J. Wahyudi
Aiming to lessen degradations and effects on marine ecosystems, Marine Spatial Planning is used as a management method with a purpose to help lead the development and used in the marine environment. The stages of the planning are collection, management, and analysis of spatial data, and also decision support systems. This method requires tools to be able to achieve the goals effectively. Geographic Information System (GIS) and remote sensing can efficiently and effectively be used to access and summarize spatial data into information forms to evaluate the Marine Spatial Planning projects. GIS and remote sensing obviously have an essential function in terms of its opportunities and its capabilities for development and projections in the future. This review is intended to produce critical description on the study of GIS development for Marine Spatial Planning. Furthermore, this review is intended to foresee the challenges faced in its implementation in Indonesia.
为了减少海洋生态系统的退化和影响,海洋空间规划被用作一种管理方法,目的是帮助引导发展并在海洋环境中使用。规划的阶段包括空间数据的收集、管理和分析,以及决策支持系统。这种方法需要能够有效实现目标的工具。地理信息系统(GIS)和遥感可以有效地用于获取空间数据并将其汇总为信息形式,以评估海洋空间规划项目。地理信息系统和遥感显然在其未来发展和预测的机会和能力方面具有重要作用。本综述旨在对用于海洋空间规划的地理信息系统开发研究进行批判性描述。此外,本次审查的目的是预见在印度尼西亚执行过程中面临的挑战。
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引用次数: 3
Recovery and Purification of Glycerine as By-product from Philippine Coconut Methyl Ester 菲律宾椰子甲酯副产物甘油的回收与纯化
Q4 Environmental Science Pub Date : 2020-05-14 DOI: 10.29037/ajstd.559
A. Briones
The study is about the recovery and purification of glycerine as a by-product from coconut methyl ester production in the Philippines. The aqueous layer produced from settling or phase splitting of the methyl ester after the transesterification process was subjected to various treatments like acidification, neutralization, concentration in vacuo in order to get back the crude glycerine. The crude glycerine obtained from the laboratory and scale-up process conformed with the specification set by the British standard for crude glycerine. The recovered glycerine is composed of: 84.92%, glycerine; 8.03%, ash; 4.72%, H20; 2.32%, MONG. Further distillation yielded a refined glycerine that meets with the specification set by USP. The average glycerine content of refined glycerine is 96.86%; ash, 0.06%; water, 1.10%, refractive index @ 20°C, 1.4696, specific gravity at 25°C, 1.296 g.
这项研究是关于回收和纯化菲律宾椰子甲酯生产中的副产品甘油。对酯交换过程后由甲酯沉淀或分相产生的水层进行各种处理,如酸化、中和、真空浓缩,以回收粗甘油。通过实验室和放大过程获得的粗甘油符合英国粗甘油标准规定的规格。回收的甘油成分为:甘油84.92%;8.03%,灰分;4.72%,H20;2.32%。进一步蒸馏得到符合USP规定规格的精制甘油。精制甘油的平均甘油含量为96.86%;灰分0.06%;水,1.10%,20°C时折射率1.4696,25°C时比重1.296g。
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引用次数: 2
Comparison of 3D Coral Photogrammetry and Coral Video Transect for Coral Lifeform Analysis Using Low-cost Underwater Action Camera 用低成本水下运动相机进行珊瑚生命形态分析的三维珊瑚摄影测量与珊瑚视频样带的比较
Q4 Environmental Science Pub Date : 2020-04-30 DOI: 10.29037/AJSTD.602
Zuhairi Ahmad, Muhammad Idzham Helmi Bin Mohd Jinah, S. Saad
This research analysed the use of 3D Coral Photogrammetry (CP) and Coral Video Transect (CVT) images collected from SCUBA divers using a low-cost underwater action camera to examine the coral lifeform. A comparison was made between data sets obtained using both methods on nine transects with different coral lifeform compositions and percentage cover within an area of 4 × 7 m. The comparison of the statistical analysis for CPCe revealed that there were no significant differences (p < 0.05) between CP and CVT photos where dead corals (p = 0.006), sand (p = 0.011), and unknown (p = 0.002) are present. Additionally, the coral value (p = 0.131) between CP and CVT was not significant. CP was capable of producing prominent branching, massive, and plate coral morphology results. This suggests that survey methods using low-cost action cameras for 3D Coral Photogrammetry would yield appropriate results in terms of coral lifeform detection. Hypothetically, by improving camera quality, it will yield a higher accuracy of 3D coral images that are suitable for use in scientific research and management. Other benefits of using CP include the possibilities for future studies with 3D coral surveys using remotely operated vehicles, less field time, and 3D coral seabed information.
这项研究分析了3D珊瑚摄影测量(CP)和珊瑚视频样带(CVT)图像的使用,这些图像是从使用低成本水下运动相机的水肺潜水员收集的,以检查珊瑚的生命形式。在4 × 7 m的面积内,用这两种方法对9个具有不同珊瑚生命形式组成和百分比覆盖率的样带进行了数据集的比较。CPCe的统计分析比较显示,CP与CVT照片在存在死珊瑚(p = 0.006)、沙(p = 0.011)和未知(p = 0.002)的情况下没有显著差异(p < 0.05)。此外,CP与CVT之间的珊瑚值(p = 0.131)不显著。CP能够产生突出的分枝、块状和板状珊瑚形态结果。这表明,使用低成本的运动相机进行3D珊瑚摄影测量的调查方法将在珊瑚生命形式检测方面产生适当的结果。假设通过提高相机质量,它将产生更高精度的3D珊瑚图像,适合用于科学研究和管理。使用CP的其他好处还包括,未来可以使用远程操作车辆进行3D珊瑚调查,减少现场时间,并获得3D珊瑚海底信息。
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引用次数: 3
期刊
Asean Journal on Science and Technology for Development
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