Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1295
Kapse Sanket, Jadhav Prakash, Redasani Vivekkumar
Pharmaceutical such achemicals can be administered locally to sick locations using target-specific drug-delivery devices.Some of the carriers used in various drug delivery techniques includesynthetic polymers, serum proteins, and immune globulins, liposomes, and microspheres. Niosomes' vesicular system, which features a bilayer structure made possible by nonionic surfactants, has the capacity to extend the time that a medicine is accessible in a specific region .Capturing hydrophilic molecules in niosomes or lipophilic medicines is enhanced by their amphiphilic character. To keep the niosomes' structure rigid, additional chemicals like cholesterol can be added. The key features of niosomes, such as their structural components, production methods, limitations, and current applications to a range of the narrative review mentions disorders briefly.
{"title":"Overview on Niosome","authors":"Kapse Sanket, Jadhav Prakash, Redasani Vivekkumar","doi":"10.22270/ajprd.v11i4.1295","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1295","url":null,"abstract":"Pharmaceutical such achemicals can be administered locally to sick locations using target-specific drug-delivery devices.Some of the carriers used in various drug delivery techniques includesynthetic polymers, serum proteins, and immune globulins, liposomes, and microspheres. Niosomes' vesicular system, which features a bilayer structure made possible by nonionic surfactants, has the capacity to extend the time that a medicine is accessible in a specific region .Capturing hydrophilic molecules in niosomes or lipophilic medicines is enhanced by their amphiphilic character. To keep the niosomes' structure rigid, additional chemicals like cholesterol can be added. The key features of niosomes, such as their structural components, production methods, limitations, and current applications to a range of the narrative review mentions disorders briefly.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1311
Varsha R. Sharma, Jigna Patel, Dhruval Padadhariya, Wasim Kazi
Phenomena of vidradhi formation is due to vitiation of dosha resides in asthi and spreads and vitiates to the twacha, rakta, mamsa, meda and gradually reformed into excessively severe inflammatory swelling, which is maha-mulam (deep rooted), rujavantam (severe painful) vruttam (round) or aayatam (elongated in shape) that is calledvidhradhi1. In case of pei-anal abscess, originates from an infection arising in the crypto glandular epithelium lin-ing of the anal canal spreading into adjacent space and resulting in fistulas 40% of cases. Sheegravidahitvat definition of Vidradhi means virulence of disease. Acharya Sushruta mentions that if vidradhi attains pakvaavastha, the first line of treatment is to drain the pus through bhedana and later, it should be treated as Vrana. In the present context, a 52 years old male suffering from left sided gluteal abscess was admitted and treated with surgical incision and drainage This case ofanal abscess (gudavidradhi) so,application of nimbadi ointment after bhedankarma (incision and drainage) is the line of treatment.
{"title":"Application of Nimbadi Ointment after Chhedankarma in the Management of Gudavidradhi-A Case Study","authors":"Varsha R. Sharma, Jigna Patel, Dhruval Padadhariya, Wasim Kazi","doi":"10.22270/ajprd.v11i4.1311","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1311","url":null,"abstract":"Phenomena of vidradhi formation is due to vitiation of dosha resides in asthi and spreads and vitiates to the twacha, rakta, mamsa, meda and gradually reformed into excessively severe inflammatory swelling, which is maha-mulam (deep rooted), rujavantam (severe painful) vruttam (round) or aayatam (elongated in shape) that is calledvidhradhi1. In case of pei-anal abscess, originates from an infection arising in the crypto glandular epithelium lin-ing of the anal canal spreading into adjacent space and resulting in fistulas 40% of cases. Sheegravidahitvat definition of Vidradhi means virulence of disease. Acharya Sushruta mentions that if vidradhi attains pakvaavastha, the first line of treatment is to drain the pus through bhedana and later, it should be treated as Vrana. In the present context, a 52 years old male suffering from left sided gluteal abscess was admitted and treated with surgical incision and drainage This case ofanal abscess (gudavidradhi) so,application of nimbadi ointment after bhedankarma (incision and drainage) is the line of treatment.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
When a vein becomes dilated, elongated and tortuous, the veins is said varicose. The common sight of varicosity are superficial venous system of lower limb effecting either long or short saphenous veins, oesophageal varices, varicosity of haemorrhoidal veins, varicosity of spermatic veins. Generally varicose veins are compared with sirajgranthi according to Ayurveda. Acharya Sushruta had described various types of granthi and its various treatment modalities among them jalaukaavacharana is one of them. Sushruta had given special chapter related to jalauka in which he had described the types, nomenclature, specific qualities of each types of jalauka, their method to apply and detach and how to do vamana of jalauka. Acharya charak also described jalauka as best amongst all anushashtras. Jalaukapossesessheet guna in nature and on the basis of sign and symptoms varicose veins can be correlated with sirajgranthi. In this case study a 36- year old woman of bilateral varicose veins was treated successfully and found symptomatic relief.
{"title":"Role of Jalokaavacharana in the Management of Varicose Veins (Sirajgranthi)- A Case Study","authors":"Wasim Kazi, Jigna Patel, Varsha Sharma, Sonal Panchal","doi":"10.22270/ajprd.v11i4.1305","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1305","url":null,"abstract":"When a vein becomes dilated, elongated and tortuous, the veins is said varicose. The common sight of varicosity are superficial venous system of lower limb effecting either long or short saphenous veins, oesophageal varices, varicosity of haemorrhoidal veins, varicosity of spermatic veins. Generally varicose veins are compared with sirajgranthi according to Ayurveda. Acharya Sushruta had described various types of granthi and its various treatment modalities among them jalaukaavacharana is one of them. Sushruta had given special chapter related to jalauka in which he had described the types, nomenclature, specific qualities of each types of jalauka, their method to apply and detach and how to do vamana of jalauka. Acharya charak also described jalauka as best amongst all anushashtras. Jalaukapossesessheet guna in nature and on the basis of sign and symptoms varicose veins can be correlated with sirajgranthi. In this case study a 36- year old woman of bilateral varicose veins was treated successfully and found symptomatic relief.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1308
Damini Parmar, Jigna Patel, Dhruval Padadharia, Divyabahen S. Ninama
Since ancient times Ashmari is mentioned in Ayurvedic texts. Ashmari is a disease related to the urinary system (Mutravahasrotas). Mutrashmari is described under Asthamahagad (difficult to cure) in Ayurveda. It possesses symptoms such as Jwara (Fever), Basti Pida (Discomfort and pain in the bladder), Aruchi (Anorexia), Mutrakriccha(Difficulty in micturition), Bastishira Vedana (Pain in Urethra), Mushka Vedana (Pain in testicles) and Shepha Vedana (Pain in the penis) have been described in Ayurvedic classical texts. A 34-year-old female patient visited OPD, with complaints of pain in the right side of the Abdomen, Burning Micturition, Nausea and Vomiting. The USG reported calculus measuring 16-17mm in right upper ureter 5mm in lower calyx of right kidney and few tiny 3-4 mm in right kidney 5-4 mm in Left kidneywith the normal functioning of vitals. The patient was treated with Chandraprabha Vati 2 BD, GokshuradiGuggulu 2 BD, Gokshurchurna +Punarnava churnaand Hajrulyahoodbhasma BD on OPD basis. The patient was advised initially follow up after 7 days and later after every 15 days. Along with medication, the patient was also advised to follow diet and lifestyle restrictions. The patient got relief in signs and symptoms and the USG report showed size of calculus decrease and some small calculi expelled.
{"title":"Ayurvedic Management of Ashmari – A Single Case Study","authors":"Damini Parmar, Jigna Patel, Dhruval Padadharia, Divyabahen S. Ninama","doi":"10.22270/ajprd.v11i4.1308","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1308","url":null,"abstract":"Since ancient times Ashmari is mentioned in Ayurvedic texts. Ashmari is a disease related to the urinary system (Mutravahasrotas). Mutrashmari is described under Asthamahagad (difficult to cure) in Ayurveda. It possesses symptoms such as Jwara (Fever), Basti Pida (Discomfort and pain in the bladder), Aruchi (Anorexia), Mutrakriccha(Difficulty in micturition), Bastishira Vedana (Pain in Urethra), Mushka Vedana (Pain in testicles) and Shepha Vedana (Pain in the penis) have been described in Ayurvedic classical texts. A 34-year-old female patient visited OPD, with complaints of pain in the right side of the Abdomen, Burning Micturition, Nausea and Vomiting. The USG reported calculus measuring 16-17mm in right upper ureter 5mm in lower calyx of right kidney and few tiny 3-4 mm in right kidney 5-4 mm in Left kidneywith the normal functioning of vitals. The patient was treated with Chandraprabha Vati 2 BD, GokshuradiGuggulu 2 BD, Gokshurchurna +Punarnava churnaand Hajrulyahoodbhasma BD on OPD basis. The patient was advised initially follow up after 7 days and later after every 15 days. Along with medication, the patient was also advised to follow diet and lifestyle restrictions. The patient got relief in signs and symptoms and the USG report showed size of calculus decrease and some small calculi expelled.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1313
Manan Shah, Vishal Shah
Global patients depend on medications for their specific purposes. These drugs are manufactured both domestically and internationally. Regardless of where they are manufactured, the Food and Drug Administration (FDA) plays a pivotal role in the United States, regulating drugs, biologics, and devices by not only scrutinizing each marketing holder's application but also guaranteeing that the product's manufacturer complies with current good manufacturing practices (cGMP). This ensures that the product's quality is consistent and is manufactured securely for its intended use.
{"title":"Inspections – Key Role in Quality of Medicines","authors":"Manan Shah, Vishal Shah","doi":"10.22270/ajprd.v11i4.1313","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1313","url":null,"abstract":"Global patients depend on medications for their specific purposes. These drugs are manufactured both domestically and internationally. Regardless of where they are manufactured, the Food and Drug Administration (FDA) plays a pivotal role in the United States, regulating drugs, biologics, and devices by not only scrutinizing each marketing holder's application but also guaranteeing that the product's manufacturer complies with current good manufacturing practices (cGMP). This ensures that the product's quality is consistent and is manufactured securely for its intended use.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1312
Sonal Panchal, Jigna Patel, Wasim Kazi, Divyabahen S. Ninama
Pain has been described by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage”. Shoulder pain is one of the most common health problems encountered in the general population.Shoulder pain is a common symptom, in especially in office workers. In developed countries, approximately twothirds of people experience shoulder pain. This disorder occurs most frequently in the middle-aged population and more often in females than in males. A majority of the acute shoulder sufferers obtain spontaneous relief within days or weeks, although approximately 10% of acute shoulder pain suffers experience the condition as chronic or persistent. Conventional treatments such as medications and surgery were not always effective, and may have serious adverse effects. Frozen shoulder is a chronic aseptic inflammation caused by injury and degeneration of shoulder capsule and periarthritic soft tissue (including ligaments, muscles, tendons, synovial sacs, etc.). [i]Cupping is gaining popularity in physical medicine due to its ease of use, lack of side effects, and pain relief. This study looked at the efficacy of cupping therapy for treating shoulder pain. Cupping therapy (CT) is a traditional Chinese medical (TCM) treatment which has been practiced for thousands of years. The World Health Organization’s (WHO) definition of cupping is a therapeutic method involving the application of suction by creating a vacum. This is typically done using fire in a cup or jar on the dermis of the affected part of the body.[ii] In this case study a patient diagnosed with AVABAHUK (Frozen Shoulder) was treated with a WET CUPPING THERAPY. After completion of cupping therapy significant relief was observed in symptoms.
{"title":"A Single Case Study of Cupping Therapy in AVABAHUK (Frozen Shoulder).","authors":"Sonal Panchal, Jigna Patel, Wasim Kazi, Divyabahen S. Ninama","doi":"10.22270/ajprd.v11i4.1312","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1312","url":null,"abstract":"Pain has been described by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage”. Shoulder pain is one of the most common health problems encountered in the general population.Shoulder pain is a common symptom, in especially in office workers. In developed countries, approximately twothirds of people experience shoulder pain. This disorder occurs most frequently in the middle-aged population and more often in females than in males. A majority of the acute shoulder sufferers obtain spontaneous relief within days or weeks, although approximately 10% of acute shoulder pain suffers experience the condition as chronic or persistent. Conventional treatments such as medications and surgery were not always effective, and may have serious adverse effects. Frozen shoulder is a chronic aseptic inflammation caused by injury and degeneration of shoulder capsule and periarthritic soft tissue (including ligaments, muscles, tendons, synovial sacs, etc.). [i]Cupping is gaining popularity in physical medicine due to its ease of use, lack of side effects, and pain relief. This study looked at the efficacy of cupping therapy for treating shoulder pain. Cupping therapy (CT) is a traditional Chinese medical (TCM) treatment which has been practiced for thousands of years. The World Health Organization’s (WHO) definition of cupping is a therapeutic method involving the application of suction by creating a vacum. This is typically done using fire in a cup or jar on the dermis of the affected part of the body.[ii] In this case study a patient diagnosed with AVABAHUK (Frozen Shoulder) was treated with a WET CUPPING THERAPY. After completion of cupping therapy significant relief was observed in symptoms.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1283
Tushar Kumar G. Ingle, S. D. Pande, S. Atram, N. Bobade, Vikrant Wankhede
The objective of this study was to develop sustained release microspheres for colon-targeted drug delivery system to enhance therapeutic efficacy while minimizing systemic side effects. The controlled and prolonged release of drugs in the colon can significantly improve the treatment outcomes for various colon-related diseases. Microspheres, small spherical particles with sizes ranging from 1 to 1000 micrometers, were formulated using biodegradable polymers and natural materials to ensure biocompatibility and controlled drug release. The formulation process involved the selection of appropriate polymers, such as poly lactic acid and polyglycolic acid, and the incorporation of the drug within the microspheres. Various techniques, including solvent evaporation, coacervation, and spray drying, were employed to prepare the microspheres with the desired drug-loading efficiency and particle size distribution.The formulated microspheres were extensively evaluated to assess their suitability for sustained release colon-targeted drug delivery. Evaluation parameters included drug encapsulation efficiency, particle size distribution, surface morphology and in vitro.In vitro drug release studies were conducted using simulated gastrointestinal fluids to mimic the conditions in the gastrointestinal tract. The sustained release microspheres exhibited controlled drug release over an extended period, specifically in the colon region. This sustained release profile was achieved by optimizing the polymer composition and formulation parameters, which allowed for the gradual degradation of the microspheres and subsequent release of the drug.
{"title":"Formulation and Evaluation of Microspheres for Colon Targeted Drug Delivery Using Anthelminthics Drugs","authors":"Tushar Kumar G. Ingle, S. D. Pande, S. Atram, N. Bobade, Vikrant Wankhede","doi":"10.22270/ajprd.v11i4.1283","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1283","url":null,"abstract":"The objective of this study was to develop sustained release microspheres for colon-targeted drug delivery system to enhance therapeutic efficacy while minimizing systemic side effects. The controlled and prolonged release of drugs in the colon can significantly improve the treatment outcomes for various colon-related diseases. Microspheres, small spherical particles with sizes ranging from 1 to 1000 micrometers, were formulated using biodegradable polymers and natural materials to ensure biocompatibility and controlled drug release. The formulation process involved the selection of appropriate polymers, such as poly lactic acid and polyglycolic acid, and the incorporation of the drug within the microspheres. Various techniques, including solvent evaporation, coacervation, and spray drying, were employed to prepare the microspheres with the desired drug-loading efficiency and particle size distribution.The formulated microspheres were extensively evaluated to assess their suitability for sustained release colon-targeted drug delivery. Evaluation parameters included drug encapsulation efficiency, particle size distribution, surface morphology and in vitro.In vitro drug release studies were conducted using simulated gastrointestinal fluids to mimic the conditions in the gastrointestinal tract. The sustained release microspheres exhibited controlled drug release over an extended period, specifically in the colon region. This sustained release profile was achieved by optimizing the polymer composition and formulation parameters, which allowed for the gradual degradation of the microspheres and subsequent release of the drug.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1282
Ninad S. Burkhande, V. P. Wankhade, S. Atram, N. Bobade, S. D. Pande
Co-crystallization is a useful crystal engineering approach for changing the physiochemical and structural characteristics of drug crystals. Pharmaceutical co-crystals are nonionic supramolecular complexes that can be utilized in pharmaceutical development to change physiochemical qualities including solubility, stability, and bioavailability without changing the chemical makeup of API. Canagliflozin Hemihydrate is a anti-diabetic drug. Canagliflozin belongs to class IV drug in BCS classification. i.e. low solubility and low permeability. The major problem of this class drug is it slow solubility in biological fluids,which results into poor bioavailability after oral administration. The purpose of this study was to prepare pharmaceutical co-crystals ofCanagliflozin to enhance solubility and dissolution rate by using co-crystallization technique. The co-former used inthis study is Thiourea. The Optimized co-crystal was characterized by FTIR, XRPD, SEM and other pharmaceutical properties like solubility and melting point were alsoevaluated.
{"title":"Development of Co-Crystallization Technique to Improve Solubility of Anti-Diabetic Drug","authors":"Ninad S. Burkhande, V. P. Wankhade, S. Atram, N. Bobade, S. D. Pande","doi":"10.22270/ajprd.v11i4.1282","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1282","url":null,"abstract":"Co-crystallization is a useful crystal engineering approach for changing the physiochemical and structural characteristics of drug crystals. Pharmaceutical co-crystals are nonionic supramolecular complexes that can be utilized in pharmaceutical development to change physiochemical qualities including solubility, stability, and bioavailability without changing the chemical makeup of API. Canagliflozin Hemihydrate is a anti-diabetic drug. Canagliflozin belongs to class IV drug in BCS classification. i.e. low solubility and low permeability. The major problem of this class drug is it slow solubility in biological fluids,which results into poor bioavailability after oral administration. The purpose of this study was to prepare pharmaceutical co-crystals ofCanagliflozin to enhance solubility and dissolution rate by using co-crystallization technique. The co-former used inthis study is Thiourea. The Optimized co-crystal was characterized by FTIR, XRPD, SEM and other pharmaceutical properties like solubility and melting point were alsoevaluated.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The field of innovative medication delivery has greatly benefited from nanotechnology and miniaturisation, which have also transformed the potential in the current healthcare industry. The design of nano-scale drug carriers using various nanotechnology-based approaches for the delivery of lipophilic drug molecules is the current trend in novel drug delivery-based research. Nanotechnology and miniaturisation, which have also changed the possibilities in the contemporary healthcare business, have tremendously helped the field of inventive medicine distribution. Targeting medication distribution in a regulated manner is made possible in large part by NSs. The use of NSs, its preparation, and assessment have all been covered in this review paper. The healthcare industry is seeing encouraging results from a variety of nanosponges formulations, including parenteral, topical, oral, and inhalation, which offer enormous promise for future development and study.
{"title":"A Comprehensive Review on Transdermal Delivery of Nanosponges","authors":"Raut Poonam, Jadhav Prakash, Sangar Priyanka, Redasani Vivekkumar, Bhosale Nikita, Joshi Varda","doi":"10.22270/ajprd.v11i4.1298","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1298","url":null,"abstract":"The field of innovative medication delivery has greatly benefited from nanotechnology and miniaturisation, which have also transformed the potential in the current healthcare industry. The design of nano-scale drug carriers using various nanotechnology-based approaches for the delivery of lipophilic drug molecules is the current trend in novel drug delivery-based research. Nanotechnology and miniaturisation, which have also changed the possibilities in the contemporary healthcare business, have tremendously helped the field of inventive medicine distribution. Targeting medication distribution in a regulated manner is made possible in large part by NSs. The use of NSs, its preparation, and assessment have all been covered in this review paper. The healthcare industry is seeing encouraging results from a variety of nanosponges formulations, including parenteral, topical, oral, and inhalation, which offer enormous promise for future development and study.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1291
Rutuja Patole, Bharatee Chaware, Vishal Mohite, V. Redasani
Inadequate pharmacokinetic properties may be connected with the widespread use of oral dose forms in disease treatment. Because of the formulation's rapid transit through the gastrointestinal tract (GIT), it can be challenging to achieve therapeutic levels of the medicine in specific situations when it is barely soluble; In addition, some medications must work locally due to a gastric disease, although they only last a short period in the stomach. Numerous studies have been done to identify formulations that can enhance all of these characteristics while extending stomach residence time. Many orally delivered medications advantageous for from the extended stomach retention time provided by gastroretentive controlled drug delivery systems.With a focus on current methods for extending stomach residence duration, the study's objective was to examine, gather, and present the preceding and contemporary literatures in a shorter format. The current review briefly discusses the need for GRDDS., Pharmaceutical importance’s of GRDDS, Physiology of stomach, Stomach functionalities, Approaches of GRDDS, factors controlling gastric retention, advantages , disadvantages, Method of preparation of Gastro-retentive Multiparticulate system, Polymeric material in gastroretentive formulations, Evaluation of Gastroretentive dosage form, comparsion between Conventional and Gastroretentive drug delivery system.
{"title":"A Review for Gastro - Retentive Drug Delivery System","authors":"Rutuja Patole, Bharatee Chaware, Vishal Mohite, V. Redasani","doi":"10.22270/ajprd.v11i4.1291","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1291","url":null,"abstract":"Inadequate pharmacokinetic properties may be connected with the widespread use of oral dose forms in disease treatment. Because of the formulation's rapid transit through the gastrointestinal tract (GIT), it can be challenging to achieve therapeutic levels of the medicine in specific situations when it is barely soluble; In addition, some medications must work locally due to a gastric disease, although they only last a short period in the stomach. Numerous studies have been done to identify formulations that can enhance all of these characteristics while extending stomach residence time. Many orally delivered medications advantageous for from the extended stomach retention time provided by gastroretentive controlled drug delivery systems.With a focus on current methods for extending stomach residence duration, the study's objective was to examine, gather, and present the preceding and contemporary literatures in a shorter format. The current review briefly discusses the need for GRDDS., Pharmaceutical importance’s of GRDDS, Physiology of stomach, Stomach functionalities, Approaches of GRDDS, factors controlling gastric retention, advantages , disadvantages, Method of preparation of Gastro-retentive Multiparticulate system, Polymeric material in gastroretentive formulations, Evaluation of Gastroretentive dosage form, comparsion between Conventional and Gastroretentive drug delivery system.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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