Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1293
Raman S. Bhopale, Rajesh D. Jangam, Harshada M. Dhekale, Prachi P. Aiwale, Vitthal J. Chaware, Vivekkumar K. Redasani
Skin damage is known as a wound. Hemostasis, inflammatory, proliferative, and tissue remodelling or resolution are the four perfectly timed and highly planned phases that make up the normal biological process of wound healing in the human body. There are two basic categories of wounds: acute wounds and chronic wounds. Long-term negative effects on one's health are caused by the chronic metabolic condition known as diabetes mellitus, which is becoming more common. 25 percent of those with diabetes mellitus are thought to have poor wound healing due to their diabetes. Oxygenation, infection, hormones related to ageing and sex, stress, diabetes, and obesity, drugs, alcoholism, smoking, and diet are among the factors that affect wound healing. To address their basic medical needs, According to estimates, 80% of people who live in underdeveloped nations need traditional medicines, which are typically made from medicinal plants. Numerous individuals in Africa and other poor nations employ using medicinal herbs to cure diabetic wounds and associated issues due to the abundant supply With therapeutic herbs and enough conventional wisdom regarding wounds healing. Recent developments in functional genomics, nanotechnology, wound healing in diabetics, along with a better knowing the pathophysiology of chronic wounds. In the following review, detailed information about healing of diabetic wounds with mechanism, factors affecting, impairment of wound healing with its pathophysiology, herbal treatments and current advances when treating diabetic wounds are examined.
{"title":"A Detailed Review on Diabetic Wound Healing Activity","authors":"Raman S. Bhopale, Rajesh D. Jangam, Harshada M. Dhekale, Prachi P. Aiwale, Vitthal J. Chaware, Vivekkumar K. Redasani","doi":"10.22270/ajprd.v11i4.1293","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1293","url":null,"abstract":"Skin damage is known as a wound. Hemostasis, inflammatory, proliferative, and tissue remodelling or resolution are the four perfectly timed and highly planned phases that make up the normal biological process of wound healing in the human body. There are two basic categories of wounds: acute wounds and chronic wounds. Long-term negative effects on one's health are caused by the chronic metabolic condition known as diabetes mellitus, which is becoming more common. 25 percent of those with diabetes mellitus are thought to have poor wound healing due to their diabetes. Oxygenation, infection, hormones related to ageing and sex, stress, diabetes, and obesity, drugs, alcoholism, smoking, and diet are among the factors that affect wound healing. To address their basic medical needs, According to estimates, 80% of people who live in underdeveloped nations need traditional medicines, which are typically made from medicinal plants. Numerous individuals in Africa and other poor nations employ using medicinal herbs to cure diabetic wounds and associated issues due to the abundant supply With therapeutic herbs and enough conventional wisdom regarding wounds healing. Recent developments in functional genomics, nanotechnology, wound healing in diabetics, along with a better knowing the pathophysiology of chronic wounds. In the following review, detailed information about healing of diabetic wounds with mechanism, factors affecting, impairment of wound healing with its pathophysiology, herbal treatments and current advances when treating diabetic wounds are examined.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1280
N. R. Babu, A. Divya, Y. Padmavathi, T. Vinoda, M. S. Sree, A.G.Prasanna Lakshmi
The study aims to find out the effectiveness of the combination of citral and curcumin as antifungal compounds. Lemongrass (Cymbopogon citratus) is a valuable family of grass known due to its flavoring, medicinal, and fragrance application. Haldi (Turmeric) scientifically known as Curcuma longa belongs to familthey Zingiberaceae. Its polyphenolic compound curcumin has been showing a variety of antifungal investigations due to extensive traditional uses and very low side effects.Turmeric has beenutilized in traditional medicine for various diseases counting diabetes, hepatitis, hemorrhoids, hysteria, indigestion, skin disease, inflammation, anorexia, hepatic disorders, cough, and sinusitis. In this formulation substudy combination of two bioactive oils is considered to form an effective antifungal spray preparation. The spray preparation is helpful to achieve fast absorption of the drugs through the transdermal way of drug administration. The effectiveness and activity rate of spray preparation is more beneficial. Lemongrass oil and curcumin are dissolved in ethanol to form a stable, safe, and effective spray formulation.
{"title":"Development of New Sensitive Spectrophotometric Method for Estimation of Famciclovir Using 3-Amino Phenol","authors":"N. R. Babu, A. Divya, Y. Padmavathi, T. Vinoda, M. S. Sree, A.G.Prasanna Lakshmi","doi":"10.22270/ajprd.v11i4.1280","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1280","url":null,"abstract":"The study aims to find out the effectiveness of the combination of citral and curcumin as antifungal compounds. Lemongrass (Cymbopogon citratus) is a valuable family of grass known due to its flavoring, medicinal, and fragrance application. Haldi (Turmeric) scientifically known as Curcuma longa belongs to familthey Zingiberaceae. Its polyphenolic compound curcumin has been showing a variety of antifungal investigations due to extensive traditional uses and very low side effects.Turmeric has beenutilized in traditional medicine for various diseases counting diabetes, hepatitis, hemorrhoids, hysteria, indigestion, skin disease, inflammation, anorexia, hepatic disorders, cough, and sinusitis. In this formulation substudy combination of two bioactive oils is considered to form an effective antifungal spray preparation. The spray preparation is helpful to achieve fast absorption of the drugs through the transdermal way of drug administration. The effectiveness and activity rate of spray preparation is more beneficial. Lemongrass oil and curcumin are dissolved in ethanol to form a stable, safe, and effective spray formulation.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-13DOI: 10.22270/ajprd.v11i4.1306
Divyabahen S. Ninama, Jigna Patel, Sonal Panchal, Damini Parmar
Gridhrasi is a Shulpradhana Nanatmaja Vatavyadhi. According to Acharya Charaka, Stambha (stiffness), Ruka (pain), Toda (pricking sensation) and Spandana (twitching) are the signs and symptoms of Vataja Gridhrasi. Aruchi (anorexia), Tandra (drowsiness) and Gaurava (heaviness) are the additional symptoms of Vatakaphaja Gridhrasi. Sciatica is a major cause of illness among the working population in a developing country.It starts from hip and gradually comes down to waist, back, thigh, knee, shank and foot and affects these parts with stiffness, distress, piercing pain and with frequent quivering.In Ayurveda science, various modalities of treatment are explained for the management of Gridhrasi. Agnikarma Chikitsa is said to be superior.In modern medicine for the management of sciatica various modalities are available such as Conservative treatment, Epidural steroid injection, Peri-radicular infiltration and Surgical treatment.Purpose of the study was to evaluate the efficacy of Agnikarma therapy performed by Panch Dhatu Shalaka (five types of metals) in case of Sciatica. After giving Agnikarma sitting, we have got marked improvement in symptoms of Sciatica and also found moderately improvement in various clinical examinations of Sciatica like SLR, Cross SLR, Local tenderness etc.
{"title":"A Case Study of Agnikarma Therapy in the Management of Gridhrasi w.s.r. to Sciatica","authors":"Divyabahen S. Ninama, Jigna Patel, Sonal Panchal, Damini Parmar","doi":"10.22270/ajprd.v11i4.1306","DOIUrl":"https://doi.org/10.22270/ajprd.v11i4.1306","url":null,"abstract":"Gridhrasi is a Shulpradhana Nanatmaja Vatavyadhi. According to Acharya Charaka, Stambha (stiffness), Ruka (pain), Toda (pricking sensation) and Spandana (twitching) are the signs and symptoms of Vataja Gridhrasi. Aruchi (anorexia), Tandra (drowsiness) and Gaurava (heaviness) are the additional symptoms of Vatakaphaja Gridhrasi. Sciatica is a major cause of illness among the working population in a developing country.It starts from hip and gradually comes down to waist, back, thigh, knee, shank and foot and affects these parts with stiffness, distress, piercing pain and with frequent quivering.In Ayurveda science, various modalities of treatment are explained for the management of Gridhrasi. Agnikarma Chikitsa is said to be superior.In modern medicine for the management of sciatica various modalities are available such as Conservative treatment, Epidural steroid injection, Peri-radicular infiltration and Surgical treatment.Purpose of the study was to evaluate the efficacy of Agnikarma therapy performed by Panch Dhatu Shalaka (five types of metals) in case of Sciatica. After giving Agnikarma sitting, we have got marked improvement in symptoms of Sciatica and also found moderately improvement in various clinical examinations of Sciatica like SLR, Cross SLR, Local tenderness etc.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139350794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, nitrogen containing TiO2 nanoparticles were doped on GO and TiO2-N-GO nanocomposite was produced under laboratory conditions to treat the chemical industry wastewater containing high H2S under UV light. 1%- 1%-3%, 3%- 1%-1% and 1%- /15%-1%3 ratios for TiO2-N-GO nanocomposite composition was researched for maximal hydrogen production. The structural, optical and morphological aspects of nanocomposites were studied using XRD, UV-DRS, Raman, XPS, FESEM, and TEM. The TiO2-N-GO nanocomposite with 2% GO, exhibited enhanced photocatalytic H2 production 3450 μmol h−1 under 60 min UV light irradiation The increase of photocatalytic activity was the high N doping resulting in high porous surface in the nanocomposite.
{"title":"H2 Production From Wastewaters Containing Sulphur via Photocatalysis Using TiO2-N-GO Nanocomposite","authors":"D. Sponza","doi":"10.47485/2694-5614.1019","DOIUrl":"https://doi.org/10.47485/2694-5614.1019","url":null,"abstract":"In this study, nitrogen containing TiO2 nanoparticles were doped on GO and TiO2-N-GO nanocomposite was produced under laboratory conditions to treat the chemical industry wastewater containing high H2S under UV light. 1%- 1%-3%, 3%- 1%-1% and 1%- /15%-1%3 ratios for TiO2-N-GO nanocomposite composition was researched for maximal hydrogen production. The structural, optical and morphological aspects of nanocomposites were studied using XRD, UV-DRS, Raman, XPS, FESEM, and TEM. The TiO2-N-GO nanocomposite with 2% GO, exhibited enhanced photocatalytic H2 production 3450 μmol h−1 under 60 min UV light irradiation The increase of photocatalytic activity was the high N doping resulting in high porous surface in the nanocomposite.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76244145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amna A. Ali, O. Abdalla, Nuha M. Hassan, Amna A. Yousif, Ammar ME. Hassan, Alkhansa Mahmoud
Introduction: Cancer is a common disease worldwide, and radiotherapy is an important option for cancer treatment. P53 tumour suppressor has a role in apoptosis and cancer treatment response. P53 is phosphorylated in response to ionizing radiation by kinases of the ataxia telangiectasia mutation family (ATM). The aim of this study was to detect the DND damage response in cancer patients before and after radiation therapy through measurements the expression levels of phosphorylated P53 on T18. Material and Methods: Total of 28 cancer patients on radiotherapy were participate in this study to collect blood samples pre and post radiotherapy compared to 28 healthy people matched in age and sex as control group. P53 antibody used against Phospho-p53 (T18) was obtained from CUSABIO using enzyme linked immunosorbent assay (ELISA). Results: 21 of patients were breast cancer, and 7 of patients were Head and Neck. 6 male and 22 female. Median of age was 44 years old. Median of body mass index (BMI) for breast cancer patients was 30 while BMI for head and neck was 23. The absorbed dose for breast cancer was 40.5Gy. While the doses for Head and neck cancers were between 20Gy- 66Gy. Phosphorylated P53 expression increased significantly (P= <0.0001) in the patients preradiotherapy compared to the control group. While no significant difference observed between preradiotherapy and postradiotherapy groups (P=0.7). Individually, 19 patients showed increased in phosphorylated P53 expression postradiotherapy, while, nine patients were showed low P53 postradiotherapy, 8 of them diagnosed with breast cancer and 1 diagnosed with Oesophagus. Conclusion: phosphorylated on T18 can be consider a predictive marker for cancer. Phosphorylated P53 can be indict the DNA damage and response through its activation and proapoptotic effects. Protein expression such as P53 can be use as biomarker to demonstrate individual radiation sensitivity in cancer patients.
{"title":"Phosphorylated P53 (TP53) in Cancer Patients Undergoing Radiotherapy","authors":"Amna A. Ali, O. Abdalla, Nuha M. Hassan, Amna A. Yousif, Ammar ME. Hassan, Alkhansa Mahmoud","doi":"10.47485/2694-5614.1018","DOIUrl":"https://doi.org/10.47485/2694-5614.1018","url":null,"abstract":"Introduction: Cancer is a common disease worldwide, and radiotherapy is an important option for cancer treatment. P53 tumour suppressor has a role in apoptosis and cancer treatment response. P53 is phosphorylated in response to ionizing radiation by kinases of the ataxia telangiectasia mutation family (ATM). The aim of this study was to detect the DND damage response in cancer patients before and after radiation therapy through measurements the expression levels of phosphorylated P53 on T18.\u0000Material and Methods: Total of 28 cancer patients on radiotherapy were participate in this study to collect blood samples pre and post radiotherapy compared to 28 healthy people matched in age and sex as control group. P53 antibody used against Phospho-p53 (T18) was obtained from CUSABIO using enzyme linked immunosorbent assay (ELISA).\u0000Results: 21 of patients were breast cancer, and 7 of patients were Head and Neck. 6 male and 22 female. Median of age was 44 years old. Median of body mass index (BMI) for breast cancer patients was 30 while BMI for head and neck was 23. The absorbed dose for breast cancer was 40.5Gy. While the doses for Head and neck cancers were between 20Gy- 66Gy. Phosphorylated P53 expression increased significantly (P= <0.0001) in the patients preradiotherapy compared to the control group. While no significant difference observed between preradiotherapy and postradiotherapy groups (P=0.7). Individually, 19 patients showed increased in phosphorylated P53 expression postradiotherapy, while, nine patients were showed low P53 postradiotherapy, 8 of them diagnosed with breast cancer and 1 diagnosed with Oesophagus.\u0000Conclusion: phosphorylated on T18 can be consider a predictive marker for cancer. Phosphorylated P53 can be indict the DNA damage and response through its activation and proapoptotic effects. Protein expression such as P53 can be use as biomarker to demonstrate individual radiation sensitivity in cancer patients.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80749983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.22270/ajprd.v11i3.1277
Dr R.A.Mahadik, Dr V. K. Redasani, P. D. Jadhav, P.D.Bhagat
Since the previous four decades, the idea of mucoadhesion has attracted significant interest across a range of pharmaceutics domains.Because mucosal membranes are relatively permeable, the mucoadhesive drug delivery system is a well-liked innovative drug delivery technique, allowing for the rapid uptake of a medication into the systemic circulation and avoiding the first pass metabolism. Recent years have seen the development of a number of mucoadhesive drug delivery systems for nasal, buccal, oral, vaginal, and rectal routes for both local and systemic effects.The mucus membrane, which covers the mucin molecules and the mucosal epithelial surface, can interact with mucoadhesive drug delivery systems. This interaction increases the dosage form's residence time at the site of absorption, increasing medication bioavailability and effectiveness while also enhancing therapeutic results.
{"title":"Review on a Oral Mucoadhesive Drug Delivery System","authors":"Dr R.A.Mahadik, Dr V. K. Redasani, P. D. Jadhav, P.D.Bhagat","doi":"10.22270/ajprd.v11i3.1277","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1277","url":null,"abstract":"Since the previous four decades, the idea of mucoadhesion has attracted significant interest across a range of pharmaceutics domains.Because mucosal membranes are relatively permeable, the mucoadhesive drug delivery system is a well-liked innovative drug delivery technique, allowing for the rapid uptake of a medication into the systemic circulation and avoiding the first pass metabolism. Recent years have seen the development of a number of mucoadhesive drug delivery systems for nasal, buccal, oral, vaginal, and rectal routes for both local and systemic effects.The mucus membrane, which covers the mucin molecules and the mucosal epithelial surface, can interact with mucoadhesive drug delivery systems. This interaction increases the dosage form's residence time at the site of absorption, increasing medication bioavailability and effectiveness while also enhancing therapeutic results.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nowadays, the majority of fungal infections, including candidiasis, can cause anything from a minor mucous membrane infection to fatal systemic mycoses. Due to the most rapid increase in populations with impaired hosts, such as those with HIV/AIDS, organ transplant recipients, and chemotherapy patients, candida infections present a serious clinical challenge internationally. In addition, a dramatic rise in the number of elderly people who are vulnerable to fungal infections is anticipated in the next decades. Due to the eukaryotic structure of the cells, developing antifungal medications for these issues is more challenging than developing antibacterial medications. Therefore, there are now only a limited number of antifungal medications available to treat the wide range of fungal infections. Additionally, the antifungal arsenal against fungal diseases has been constrained by the rise in antifungal resistance and unfavourable host effects.
{"title":"An Overview on Antifungal Drug Therapy","authors":"Mayuri More, Prakash Jadhav, Ashish Bhongale, A. Velhal, Vivek Kumar Redasani, Nishigandha Naikawadi","doi":"10.22270/ajprd.v11i3.1270","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1270","url":null,"abstract":"Nowadays, the majority of fungal infections, including candidiasis, can cause anything from a minor mucous membrane infection to fatal systemic mycoses. Due to the most rapid increase in populations with impaired hosts, such as those with HIV/AIDS, organ transplant recipients, and chemotherapy patients, candida infections present a serious clinical challenge internationally. In addition, a dramatic rise in the number of elderly people who are vulnerable to fungal infections is anticipated in the next decades. Due to the eukaryotic structure of the cells, developing antifungal medications for these issues is more challenging than developing antibacterial medications. Therefore, there are now only a limited number of antifungal medications available to treat the wide range of fungal infections. Additionally, the antifungal arsenal against fungal diseases has been constrained by the rise in antifungal resistance and unfavourable host effects.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139364367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Due to their extended shelf life, enhanced drug solubilization, and simplicity in preparation and administration, microemulsions are among the greatest possibilities for new drug delivery systems. Microemulsions are liquid mixtures of amphiphile, water, and oil that are thermodynamically stable and optically isotropic. They have become cutting-edge drug delivery systems that enable controlled or sustained release for parenteral, ophthalmic, percutaneous, topical, and transdermal medication administration.Because of their low viscosity, transparency, and, more precisely, their thermodynamic stability, microemulsions may be easily distinguished from regular emulsions. Microemulsions have a wide range of uses and applications, including in the pharmaceutical, agrochemical, cutting oil, biotechnology, food, and cosmetic industries as well as in analytical applications and environmental detoxification. This review paper's main goal is to talk about using microemulsions as a medicine delivery mechanism with other potential uses.
{"title":"An Overview on Microemulsion as a Topical Drug Delivry System","authors":"Naikawadi Nishigandha, Jadhav Prakash, Bhagwat Avinash, Velhal Atish, Redasani Vivek Kumar, More Mayuri","doi":"10.22270/ajprd.v11i3.1275","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1275","url":null,"abstract":"Due to their extended shelf life, enhanced drug solubilization, and simplicity in preparation and administration, microemulsions are among the greatest possibilities for new drug delivery systems. Microemulsions are liquid mixtures of amphiphile, water, and oil that are thermodynamically stable and optically isotropic. They have become cutting-edge drug delivery systems that enable controlled or sustained release for parenteral, ophthalmic, percutaneous, topical, and transdermal medication administration.Because of their low viscosity, transparency, and, more precisely, their thermodynamic stability, microemulsions may be easily distinguished from regular emulsions. Microemulsions have a wide range of uses and applications, including in the pharmaceutical, agrochemical, cutting oil, biotechnology, food, and cosmetic industries as well as in analytical applications and environmental detoxification. This review paper's main goal is to talk about using microemulsions as a medicine delivery mechanism with other potential uses.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The pharmaceutical term “emulsion” is most time used to indicate preparations prepared for internal use. This pharmaceutical dosage form is thermodynamically unstable and must be stabilized by the addition of emulsifying agent. Emulsified systems range from lotions having comparatively low viscosity to creams which are more viscous. There are two basic types of emulsions, that is, oil in water (O/W) and water in oil (W/O). In addition to these two types, a relatively complex emulsion, called multiple emulsions can also be formulated. Emulsions generally have certain advantages over other dosage forms as the drug solubilized may be more bioavailable. Moreover, gastrointestinal problems and first pass metabolic effect are also avoided.
{"title":"A Review on Pharmaceutical Emulsion","authors":"Rakesh Thakur, Anjali Sharma, Preeti Verma, Asha Devi","doi":"10.22270/ajprd.v11i3.1181","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1181","url":null,"abstract":"The pharmaceutical term “emulsion” is most time used to indicate preparations prepared for internal use. This pharmaceutical dosage form is thermodynamically unstable and must be stabilized by the addition of emulsifying agent. Emulsified systems range from lotions having comparatively low viscosity to creams which are more viscous. There are two basic types of emulsions, that is, oil in water (O/W) and water in oil (W/O). In addition to these two types, a relatively complex emulsion, called multiple emulsions can also be formulated. Emulsions generally have certain advantages over other dosage forms as the drug solubilized may be more bioavailable. Moreover, gastrointestinal problems and first pass metabolic effect are also avoided.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.22270/ajprd.v11i3.1276
Chavan Achal, Bharatee Chaudhary, V. Redasani, P. Bhagat, R. Mahadik
Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for paediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route is the most preferred route of administration for various drugs have limitations like first-pass metabolism, psychiatric patients, bedridden and uncooperative patients. FDTs are disintegrating or dissolve quickly in the saliva without a need of water. Fast dissolving tablets are designed to dissolve in saliva remarkably faster, within a few seconds (less than 60 seconds), and those are real fast-dissolving tablets. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery in spite of various disadvantages. There are several technologies that are conventional or patented based on spray drying, cotton candy process, sublimation, melt granulation, direct compression freezes drying/lyophilization, phase transition process, mass extrusion, etc. have been developed for manufacturing of FDTs
{"title":"On Overview of Fast dissolving tablet","authors":"Chavan Achal, Bharatee Chaudhary, V. Redasani, P. Bhagat, R. Mahadik","doi":"10.22270/ajprd.v11i3.1276","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1276","url":null,"abstract":"Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for paediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route is the most preferred route of administration for various drugs have limitations like first-pass metabolism, psychiatric patients, bedridden and uncooperative patients. FDTs are disintegrating or dissolve quickly in the saliva without a need of water. Fast dissolving tablets are designed to dissolve in saliva remarkably faster, within a few seconds (less than 60 seconds), and those are real fast-dissolving tablets. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery in spite of various disadvantages. There are several technologies that are conventional or patented based on spray drying, cotton candy process, sublimation, melt granulation, direct compression freezes drying/lyophilization, phase transition process, mass extrusion, etc. have been developed for manufacturing of FDTs","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139366723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：