Pub Date : 2024-04-15DOI: 10.22270/ajprd.v12i2.1323
Madhurima Saini, Dr. Shiv Garg, Dr. Piush Sharma, Dr. Shailendra Bhatt
Drug delivery systems are methods which are used to ensure that drugs get into the body and reach the area where they are needed. These systems must take a number of needs into account, ranging from ease of delivery to effectiveness of the drugs. The paper reviews an overview of a conventional and novel approach in the topical drug delivery system. Drug delivery via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver the drug both locally and systemically. The topical route has been a favored route of drug administration over the last decades. Despite conventional topical drug delivery systems limits in poor retention and low bioavailability. To address some of the limitations posed by conventional dermatotherapy, nano-based technologies have been developed and have demonstrated a significant improvement in dermatotherapy. Their distinct physicochemical properties demonstrate their overall superior therapeutic efficacy in providing sustained and effective targeted drug release, as well as improved solubility of hydrophobic actives with optimized drug formulations. These nanocarriers are commonly classified as polymeric, lipid-based, metallic, and vesicular nanocarriers, including nanoemulsions, nanofibers, and microneedles.
{"title":"New Insights in Topical Drug Delivery for Skin Disorders: A Review","authors":"Madhurima Saini, Dr. Shiv Garg, Dr. Piush Sharma, Dr. Shailendra Bhatt","doi":"10.22270/ajprd.v12i2.1323","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1323","url":null,"abstract":"Drug delivery systems are methods which are used to ensure that drugs get into the body and reach the area where they are needed. These systems must take a number of needs into account, ranging from ease of delivery to effectiveness of the drugs. The paper reviews an overview of a conventional and novel approach in the topical drug delivery system. Drug delivery via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver the drug both locally and systemically. The topical route has been a favored route of drug administration over the last decades. Despite conventional topical drug delivery systems limits in poor retention and low bioavailability. To address some of the limitations posed by conventional dermatotherapy, nano-based technologies have been developed and have demonstrated a significant improvement in dermatotherapy. Their distinct physicochemical properties demonstrate their overall superior therapeutic efficacy in providing sustained and effective targeted drug release, as well as improved solubility of hydrophobic actives with optimized drug formulations. These nanocarriers are commonly classified as polymeric, lipid-based, metallic, and vesicular nanocarriers, including nanoemulsions, nanofibers, and microneedles.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The oral route is the most favored technique for administering the drug orally in the body. As a result of certain limitations such as drug absorption, poor bioavailability, first-pass hepatic metabolism and medicine target to particular organs, may cause problems for administration via oral route. Therefore parenteral route, transmucosal route and transdermal route are preferred over oral route. Intranasal route is deemed to be a desirable route because of the time profile of concentration a drug is close to that of the intravenous route. The nasal route has also been successfully used for bypassing the blood-brain barrier and afterword delivering drug molecules to the central nervous system .The in-situ gelling system is a process in which is in a solution form before the administration in the body but it converts in to a gel form after administration . The formation of gel depends on factors like temperature modulation, pH change, presence of ions from which drug get released in sustained and controlled manner. Therefore this review focuses on nasal drug delivery, a variety of aspects of nasal anatomy and physiology, nasal absorption mechanism, and In-Situ gels evaluations.
{"title":"A Novel Approch for Nasal Drug Delivery System","authors":"Avinash Jadhav, Prof.Vishweshwar Dharashive, Dr.Sameer Shafi, Saiprasad Chavan, Madhav Honrao, Rahul Inje, Akshay Biradar","doi":"10.22270/ajprd.v12i2.1383","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1383","url":null,"abstract":"The oral route is the most favored technique for administering the drug orally in the body. As a result of certain limitations such as drug absorption, poor bioavailability, first-pass hepatic metabolism and medicine target to particular organs, may cause problems for administration via oral route. Therefore parenteral route, transmucosal route and transdermal route are preferred over oral route. Intranasal route is deemed to be a desirable route because of the time profile of concentration a drug is close to that of the intravenous route. The nasal route has also been successfully used for bypassing the blood-brain barrier and afterword delivering drug molecules to the central nervous system .The in-situ gelling system is a process in which is in a solution form before the administration in the body but it converts in to a gel form after administration . The formation of gel depends on factors like temperature modulation, pH change, presence of ions from which drug get released in sustained and controlled manner. Therefore this review focuses on nasal drug delivery, a variety of aspects of nasal anatomy and physiology, nasal absorption mechanism, and In-Situ gels evaluations.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"321 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This comprehensive review investigates the market landscape of antihypertensive medications, undertaking a detailed comparative analysis of branded and generic options. In the face of rising global prevalence of hypertension, the study aims to provide a holistic perspective on the efficacy, safety, and market dynamics shaping the use of branded and generic drugs in the management of these chronic conditions. Utilizing data derived from market trends, sales analytics, and consumer preferences, the review scrutinizes the market behaviors and forces influencing the adoption of branded and generic antihypertensive drugs. Factors such as cost-effectiveness, patient adherence, and healthcare provider preferences are explored to shed light on the complexities associated with medication selection in the context of chronic disease management. Through an in-depth examination of industry strategies, regulatory frameworks, and the role of healthcare policies, the review aims to uncover the interplay between market dynamics and clinical considerations. It seeks to inform healthcare professionals, policymakers, and industry stakeholders about the evolving landscape of choices in antihypertensive therapies, fostering a nuanced understanding that can guide optimal decision-making in patient care and resource allocation.
{"title":"A Review: A Comparative Study of Branded and Generic Anti-Hypertensive Drugs","authors":"Anuksh Telrandhe, Ketakee Phadnis, Nilakshi Dhoble, Nitin Padole, Jagdish Baheti","doi":"10.22270/ajprd.v12i2.1359","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1359","url":null,"abstract":"This comprehensive review investigates the market landscape of antihypertensive medications, undertaking a detailed comparative analysis of branded and generic options. In the face of rising global prevalence of hypertension, the study aims to provide a holistic perspective on the efficacy, safety, and market dynamics shaping the use of branded and generic drugs in the management of these chronic conditions.\u0000Utilizing data derived from market trends, sales analytics, and consumer preferences, the review scrutinizes the market behaviors and forces influencing the adoption of branded and generic antihypertensive drugs. Factors such as cost-effectiveness, patient adherence, and healthcare provider preferences are explored to shed light on the complexities associated with medication selection in the context of chronic disease management.\u0000Through an in-depth examination of industry strategies, regulatory frameworks, and the role of healthcare policies, the review aims to uncover the interplay between market dynamics and clinical considerations. It seeks to inform healthcare professionals, policymakers, and industry stakeholders about the evolving landscape of choices in antihypertensive therapies, fostering a nuanced understanding that can guide optimal decision-making in patient care and resource allocation.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"34 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.22270/ajprd.v12i2.1333
Pallav Dave
Addressing the global burden of HIV requires effective preventative measures that have been shown to have high efficacy rates. PrEP is one of the preventative measures that is effective in preventing HIV. Different clinical trials and population studies have shown PrEPto have an efficacy rate of 40% to 90% when it comes to preventing HIV. Due to its high efficacy, PrEPcan reduce new HIV infections populations considered to be high risk. However, for efficacy to be high, there is a need to increase medication adherence and address the existing barriers that limit uptake. Some of these barriers are lack of knowledge, inadequate access, stigma,lack of trust in service providers, low perception of HIV risk, cost, and fear of side effects. Addressing these barriers can increase PrEP uptake and help in reducing HIV’s risk among high-risk populations. Some of the measures that can be put in place to address these barriers are providing education and training, allocating enough resources, leveraging technology, lowering PrEP costs, increasing insurance coverage, and improving communication among the targeted population.
要解决艾滋病毒给全球带来的负担，就必须采取有效的预防措施，这些措施已被证明具有很高的有效率。PrEP 是有效预防艾滋病毒的预防措施之一。不同的临床试验和人群研究表明，PrEP 在预防艾滋病毒方面的有效率为 40% 至 90%。由于疗效高，PrEP 可以减少被认为是高危人群的艾滋病毒新感染病例。然而，要想达到高疗效，就需要提高服药依从性，并解决现有的限制服用的障碍。其中一些障碍包括缺乏知识、获取途径不足、污名化、对服务提供者缺乏信任、对 HIV 风险认识不足、费用以及对副作用的恐惧。消除这些障碍可以提高 PrEP 的使用率，有助于降低高危人群感染 HIV 的风险。为消除这些障碍，可以采取的一些措施包括提供教育和培训、分配足够的资源、利用技术、降低 PrEP 的成本、增加保险覆盖面以及加强目标人群之间的沟通。
{"title":"Exploring the Effectiveness of Pre-Exposure Prophylaxis (PrEP) Use for HIV Prevention among High-Risk Populations","authors":"Pallav Dave","doi":"10.22270/ajprd.v12i2.1333","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1333","url":null,"abstract":"Addressing the global burden of HIV requires effective preventative measures that have been shown to have high efficacy rates. PrEP is one of the preventative measures that is effective in preventing HIV. Different clinical trials and population studies have shown PrEPto have an efficacy rate of 40% to 90% when it comes to preventing HIV. Due to its high efficacy, PrEPcan reduce new HIV infections populations considered to be high risk. However, for efficacy to be high, there is a need to increase medication adherence and address the existing barriers that limit uptake. Some of these barriers are lack of knowledge, inadequate access, stigma,lack of trust in service providers, low perception of HIV risk, cost, and fear of side effects. Addressing these barriers can increase PrEP uptake and help in reducing HIV’s risk among high-risk populations. Some of the measures that can be put in place to address these barriers are providing education and training, allocating enough resources, leveraging technology, lowering PrEP costs, increasing insurance coverage, and improving communication among the targeted population.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"57 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.22270/ajprd.v12i2.1370
Pushpraj Singh
Milk is an excellent source of all the necessary nutrients in the proper proportions. Besides the other regular constituents it has oligosaccharides in it which are indigestible by the infant yet are consumed by the microbial populations in the developing intestine. These oligosaccharides are believed to facilitate enrichment of a healthy infant gastrointestinal micro biota, often associated with bifidobacteria. Goat milk is a rich source of oligosaccharides that have enormous biological activities such as anti-bacterial, immunological, anti-inflammatory, hypoallergenic and therapeutic properties. It is used against tuberculosis in folk medicine and also helps in the enhancement of platelet count during dengue fever. Goat milk oligosaccharides have anti-inflammatory properties and are involved in the repairing process after a dextran sodium sulphate-induced colitis. Keeping in mind the biological importance of goat milk and the role of oligosaccharides, in the present studies, goat milk was analyzed for its oligosaccharide content which led to the isolation of a novel tetrasaccharide, ducose, C28H48O21N2. The structure of the isolated oligosaccharide was elucidated by chemical transformation, chemical degradation, 1H, 13C, 2D-NMR (COSY, TOCSY, HMBC and HSQC) and mass spectrometry as under. The geometry of compound ducose was optimized by B3LYP method and 6-31 G (d,p) basis set.
{"title":"Isolation, NMR and Mass Characterization of Ducose - A Novel Tetrasaccharide from Goat Milk","authors":"Pushpraj Singh","doi":"10.22270/ajprd.v12i2.1370","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1370","url":null,"abstract":"Milk is an excellent source of all the necessary nutrients in the proper proportions. Besides the other regular constituents it has oligosaccharides in it which are indigestible by the infant yet are consumed by the microbial populations in the developing intestine. These oligosaccharides are believed to facilitate enrichment of a healthy infant gastrointestinal micro biota, often associated with bifidobacteria. Goat milk is a rich source of oligosaccharides that have enormous biological activities such as anti-bacterial, immunological, anti-inflammatory, hypoallergenic and therapeutic properties. It is used against tuberculosis in folk medicine and also helps in the enhancement of platelet count during dengue fever. Goat milk oligosaccharides have anti-inflammatory properties and are involved in the repairing process after a dextran sodium sulphate-induced colitis. Keeping in mind the biological importance of goat milk and the role of oligosaccharides, in the present studies, goat milk was analyzed for its oligosaccharide content which led to the isolation of a novel tetrasaccharide, ducose, C28H48O21N2. The structure of the isolated oligosaccharide was elucidated by chemical transformation, chemical degradation, 1H, 13C, 2D-NMR (COSY, TOCSY, HMBC and HSQC) and mass spectrometry as under.\u0000The geometry of compound ducose was optimized by B3LYP method and 6-31 G (d,p) basis set.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.22270/ajprd.v12i2.1369
Pooja M. Sontakke, Suraj G. Malpani, Pooja R. Tange, MD Rayees Ahmad, Vishweshwar M. Dharashive
Epoxyeicosatrienoic acids (EETs) have numerous cardiovascular benefits, including vasodilation, anti-inflammatory actions, and anti-migratory effects on vascular smooth muscle cells. However, sEH, an enzyme that breaks down EETs into diols, limits these benefits. The development of sEH inhibitors (sEHIs), particularly those based on 1,3-disubstituted urea, has shown promise in enhancing the therapeutic properties of EETs. These inhibitors are antihypertensive and anti-inflammatory and can protect the heart, brain, and kidneys from damage. While there are still challenges to overcome, such as improving the drug-like properties of sEHIs and finding better ways to target specific tissues, the initiation of clinical trials for sEHIs highlights their potential as therapeutic agents.
{"title":"Soluble Epoxide Hydrolase","authors":"Pooja M. Sontakke, Suraj G. Malpani, Pooja R. Tange, MD Rayees Ahmad, Vishweshwar M. Dharashive","doi":"10.22270/ajprd.v12i2.1369","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1369","url":null,"abstract":"Epoxyeicosatrienoic acids (EETs) have numerous cardiovascular benefits, including vasodilation, anti-inflammatory actions, and anti-migratory effects on vascular smooth muscle cells. However, sEH, an enzyme that breaks down EETs into diols, limits these benefits. The development of sEH inhibitors (sEHIs), particularly those based on 1,3-disubstituted urea, has shown promise in enhancing the therapeutic properties of EETs. These inhibitors are antihypertensive and anti-inflammatory and can protect the heart, brain, and kidneys from damage. While there are still challenges to overcome, such as improving the drug-like properties of sEHIs and finding better ways to target specific tissues, the initiation of clinical trials for sEHIs highlights their potential as therapeutic agents.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"74 S17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.22270/ajprd.v12i2.1377
Dr. Sejal B.Padvi, Dr. Rajesh Kumar Sharma
Keloid is a type of scar that results from the overgrowth of dense fibrous tissue which is usually develops after healing of a skin injury. In other words, it represents an abnormal scar formation. The tissue extends beyond the borders of the original wound and does not usually regress spontaneously. It causes cosmetic deformity, itching, pain, and stress ultimately resulting in compromised quality of life and diminished functional performance. The treatment of Keloid is often difficult because there is an associated high risk of recurrence. Vrana represents a vast part of Shalyatantra and the pathogenesis of Keloid is similar to Vrana granthi which has been explained as a growth of mass at the site of Vrana following dietetic complications or any physical irritation in a Vrana patient. Jalaukavacharana (leech therapy) is a parasurgical type of Raktamokshana and is considered as the most unique and effective method of bloodletting. Leeches are widely used in most disorders ranging from skin disease with evidence of successful results. In the present paper, an effort has been made to case of keloid that have been conducted in Ayurveda as para surgical procedure.
{"title":"A Case study- Jalaukavacharan-Leech Therapyin management of Vranagranthi (Keloid)","authors":"Dr. Sejal B.Padvi, Dr. Rajesh Kumar Sharma","doi":"10.22270/ajprd.v12i2.1377","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1377","url":null,"abstract":"Keloid is a type of scar that results from the overgrowth of dense fibrous tissue which is usually develops after healing of a skin injury. In other words, it represents an abnormal scar formation. The tissue extends beyond the borders of the original wound and does not usually regress spontaneously. It causes cosmetic deformity, itching, pain, and stress ultimately resulting in compromised quality of life and diminished functional performance. The treatment of Keloid is often difficult because there is an associated high risk of recurrence. Vrana represents a vast part of Shalyatantra and the pathogenesis of Keloid is similar to Vrana granthi which has been explained as a growth of mass at the site of Vrana following dietetic complications or any physical irritation in a Vrana patient. Jalaukavacharana (leech therapy) is a parasurgical type of Raktamokshana and is considered as the most unique and effective method of bloodletting. Leeches are widely used in most disorders ranging from skin disease with evidence of successful results. In the present paper, an effort has been made to case of keloid that have been conducted in Ayurveda as para surgical procedure.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"82 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.22270/ajprd.v12i2.1363
Jagdale Onkar Nandraj, Khule Ashwini Gajanan, Dr. K.M. Karande
Hyperpigmentation is a common skin condition characterized by the darkening of certain areas of the skin due to an excess production of melanin. This condition can be caused by a variety of factors, including sun exposure, hormonal changes, inflammation, and skin injuries. Hyperpigmentation can have a significant impact on a person's self-esteem and quality of life. Hormonal changes, such as those experienced during pregnancy or menopause, can also lead to hyperpigmentation. Inflammation from conditions like acne or eczema can cause the skin to produce excess melanin, resulting in dark spots or patches. Additionally, skin injuries, such as cuts or burns, can trigger the body to produce more melanin as part of the healing process, leading to hyperpigmentation. Creams containing ingredients like hydroquinone, retinol, or vitamin C can help lighten dark spots and even out skin tone. Medications containing corticosteroids, may be recommended for more severe cases of hyperpigmentation. In addition, novel drug delivery systems such as liposomes, Transferosomes, Niosomes etc. have shown better penetration topically hence they can be used to treat pigmentation. Understanding the causes of hyperpigmentation and seeking appropriate treatment can help improve the overall health and appearance of the skin. By addressing the underlying factors contributing to hyperpigmentation and using targeted skincare products or treatments, individuals can achieve a more even complexion and feel more confident in their skin. Background: The topic of hyperpigmentation is of significant interest in dermatology and cosmetology due to its widespread prevalence and impact on individuals' skin health and appearance.several traditional treatments such as topical hydroquinone and retinoids have been utilized for managing hyperpigmentation, there is an increasing recognition of the need for more effective and targeted intervention.
色素沉着是一种常见的皮肤病，其特征是由于黑色素分泌过多导致皮肤某些部位变黑。造成这种情况的原因有很多，包括日晒、荷尔蒙变化、炎症和皮肤损伤。色素沉着会严重影响一个人的自尊和生活质量。荷尔蒙变化，如怀孕或更年期期间的荷尔蒙变化，也会导致色素沉着。痤疮或湿疹等炎症会导致皮肤产生过多的黑色素，从而形成黑斑或斑块。此外，皮肤受伤（如割伤或烧伤）也会促使身体在愈合过程中产生更多黑色素，从而导致色素沉着。含有对苯二酚、视黄醇或维生素 C 等成分的面霜可以帮助淡化色斑，均匀肤色。对于较严重的色素沉着，可建议使用含有皮质类固醇的药物。此外，脂质体、转运体、Niosomes 等新型给药系统显示出更好的局部渗透性，因此可用于治疗色素沉着。了解色素沉着的原因并寻求适当的治疗有助于改善皮肤的整体健康和外观。通过解决导致色素沉着的潜在因素并使用有针对性的护肤产品或治疗方法，个人可以获得更均匀的肤色，并对自己的皮肤更有信心：背景：色素沉着这一话题在皮肤病学和美容学中备受关注，因为它普遍存在并影响着个人的皮肤健康和外观。传统的治疗方法，如外用氢醌和维甲酸，已被用于控制色素沉着，但人们越来越认识到需要更有效和更有针对性的干预措施。
{"title":"A Concise Review on Contemporary and Novel Treatments Addressing the Prevention and Control of Hyperpigmentation","authors":"Jagdale Onkar Nandraj, Khule Ashwini Gajanan, Dr. K.M. Karande","doi":"10.22270/ajprd.v12i2.1363","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1363","url":null,"abstract":"Hyperpigmentation is a common skin condition characterized by the darkening of certain areas of the skin due to an excess production of melanin. This condition can be caused by a variety of factors, including sun exposure, hormonal changes, inflammation, and skin injuries. Hyperpigmentation can have a significant impact on a person's self-esteem and quality of life. Hormonal changes, such as those experienced during pregnancy or menopause, can also lead to hyperpigmentation. Inflammation from conditions like acne or eczema can cause the skin to produce excess melanin, resulting in dark spots or patches. Additionally, skin injuries, such as cuts or burns, can trigger the body to produce more melanin as part of the healing process, leading to hyperpigmentation. Creams containing ingredients like hydroquinone, retinol, or vitamin C can help lighten dark spots and even out skin tone. Medications containing corticosteroids, may be recommended for more severe cases of hyperpigmentation. In addition, novel drug delivery systems such as liposomes, Transferosomes, Niosomes etc. have shown better penetration topically hence they can be used to treat pigmentation. Understanding the causes of hyperpigmentation and seeking appropriate treatment can help improve the overall health and appearance of the skin. By addressing the underlying factors contributing to hyperpigmentation and using targeted skincare products or treatments, individuals can achieve a more even complexion and feel more confident in their skin.\u0000Background: The topic of hyperpigmentation is of significant interest in dermatology and cosmetology due to its widespread prevalence and impact on individuals' skin health and appearance.several traditional treatments such as topical hydroquinone and retinoids have been utilized for managing hyperpigmentation, there is an increasing recognition of the need for more effective and targeted intervention.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"79 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.22270/ajprd.v12i2.1361
Preetha Karuvanthodi, Jithesh M
Child maltreatment is a pervasive and complex societal issue that encompasses various forms of abuse and neglect, posing significant threats to the well-being and development of children worldwide. The World Health Organization (WHO) defines child maltreatment as “all forms of physical and emotional ill-treatment, sexual abuse, neglect, and exploitation that results in actual or potential harm to the child’s health, development or dignity.” Abuse of children can have serious short and long term effects on physical, sexual, and mental health. These include physical harm, such as concussions and severe disabilities, especially in young children, as well as anxiety, sadness, and post-traumatic stress disorder. Child abuse has a strong correlation with alcohol and drug usage and can impact cognitive and academic performance.Priority must be for protecting and preserving the safety of abused children. The goals of ongoing treatment are to lessen the long-term psychological and physical effects of abuse as well as preventing reoccurrence. Child maltreatment is a global concern with profound implications for the physical, emotional, and psychological well-being of children. While conventional approaches in the field of child protection have made significant strides, there is growing interest in exploring complementary practices, such as Ayurveda, to enhance the overall well-being of maltreated children. The potential role of Ayurveda in addressing child maltreatment, considering its ancient roots in promoting holistic health and balance is to be highlighted. Ayurveda also proposes the principles for taking care of childhood and preventing maltreatment for them. Therapies, including herbal remedies, massage, and meditation is having the potential in managing and rehabilitating the children affected by maltreatment. Ayurveda focuses in addressing not only physical symptoms but also mental and emotional aspects that aligns with the comprehensive needs of maltreated children.
{"title":"Child maltreatment and mental health- Ayurveda perspective","authors":"Preetha Karuvanthodi, Jithesh M","doi":"10.22270/ajprd.v12i2.1361","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1361","url":null,"abstract":"Child maltreatment is a pervasive and complex societal issue that encompasses various forms of abuse and neglect, posing significant threats to the well-being and development of children worldwide. The World Health Organization (WHO) defines child maltreatment as “all forms of physical and emotional ill-treatment, sexual abuse, neglect, and exploitation that results in actual or potential harm to the child’s health, development or dignity.” Abuse of children can have serious short and long term effects on physical, sexual, and mental health. These include physical harm, such as concussions and severe disabilities, especially in young children, as well as anxiety, sadness, and post-traumatic stress disorder. Child abuse has a strong correlation with alcohol and drug usage and can impact cognitive and academic performance.Priority must be for protecting and preserving the safety of abused children. The goals of ongoing treatment are to lessen the long-term psychological and physical effects of abuse as well as preventing reoccurrence.\u0000Child maltreatment is a global concern with profound implications for the physical, emotional, and psychological well-being of children. While conventional approaches in the field of child protection have made significant strides, there is growing interest in exploring complementary practices, such as Ayurveda, to enhance the overall well-being of maltreated children. The potential role of Ayurveda in addressing child maltreatment, considering its ancient roots in promoting holistic health and balance is to be highlighted.\u0000Ayurveda also proposes the principles for taking care of childhood and preventing maltreatment for them. Therapies, including herbal remedies, massage, and meditation is having the potential in managing and rehabilitating the children affected by maltreatment. Ayurveda focuses in addressing not only physical symptoms but also mental and emotional aspects that aligns with the comprehensive needs of maltreated children.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"337 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.22270/ajprd.v12i2.1366
D. Varsadiya, Dr.Rajeshkumar Sharma, D. Kanani
In Ayurveda, Acharya Sushrut mentioned an excellent treatment named Uttarbasti for urethral stricture known as Mutrakruccha in classical scriptures. Mutrakruccha translates to difficulty in micturition. It can be associated with urethral stricture due to the similarity of symptoms. Urethral stricture disease is often seen in patients with recurrent urinary tract infections, urethral injuries, or post-surgical procedures conducted through the urethra. The most common causes of urethral stricture today are traumatic or iatrogenic. Inflammatory or infectious, malignant, and congenital aetiologies are less common. There is a low success rate of Western medical science treatment for urethral stricture disease. Surgical treatment of urethral stricture disease is indicated when the patient has severe voiding symptoms, bladder calculi, increased postvoid residual, urinary tract infection, or when conservative management fails. Urinary tract infections (UTIs) should be adequately treated before surgical intervention. In this case study, a 39-year-old male patient complained of suffering from symptoms like the strangury of urine, pain during micturition, the flow of urine is very poor, frequent micturition and occasionally burning micturition. After clinical examination and radiological testing, the patient was identified as having urethral stricture and treated with Jatyadi Taila Uttarbasti for 21 days at Shalyatantra OPD, Government Akhandanand Ayurved College and Hospital, Ahmedabad. After completion of treatment, the patient felt 75% relief in symptoms. So, we can conclude that non-invasive treatment such as Uttarbasti is highly advisable in patients having Urethral stricture.
{"title":"Efficacy of Jatyadi Taila Uttarbasti in the Management of Urethral Stricture a Single Case Study","authors":"D. Varsadiya, Dr.Rajeshkumar Sharma, D. Kanani","doi":"10.22270/ajprd.v12i2.1366","DOIUrl":"https://doi.org/10.22270/ajprd.v12i2.1366","url":null,"abstract":"In Ayurveda, Acharya Sushrut mentioned an excellent treatment named Uttarbasti for urethral stricture known as Mutrakruccha in classical scriptures. Mutrakruccha translates to difficulty in micturition. It can be associated with urethral stricture due to the similarity of symptoms. Urethral stricture disease is often seen in patients with recurrent urinary tract infections, urethral injuries, or post-surgical procedures conducted through the urethra. The most common causes of urethral stricture today are traumatic or iatrogenic. Inflammatory or infectious, malignant, and congenital aetiologies are less common. There is a low success rate of Western medical science treatment for urethral stricture disease. Surgical treatment of urethral stricture disease is indicated when the patient has severe voiding symptoms, bladder calculi, increased postvoid residual, urinary tract infection, or when conservative management fails. Urinary tract infections (UTIs) should be adequately treated before surgical intervention. In this case study, a 39-year-old male patient complained of suffering from symptoms like the strangury of urine, pain during micturition, the flow of urine is very poor, frequent micturition and occasionally burning micturition. After clinical examination and radiological testing, the patient was identified as having urethral stricture and treated with Jatyadi Taila Uttarbasti for 21 days at Shalyatantra OPD, Government Akhandanand Ayurved College and Hospital, Ahmedabad. After completion of treatment, the patient felt 75% relief in symptoms. So, we can conclude that non-invasive treatment such as Uttarbasti is highly advisable in patients having Urethral stricture.\u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":"55 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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