Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1188
Lokesh T. Thote, D. Dhabarde, J. Baheti, S. Borkar, Swati Bhusari
A simple, precise and rapid reverse phase HPLC- SPD 20-Amethod has been developed and validated for the simultaneous investigation of Ambroxol Hydrochloride (AMB) and N-Acetyl Cysteine (NAC) in tablet dosage form. The mixture of (AMB) and (NAC) was separated on C18 5µm.column (4.5 µm × 25 cm). All separation were monitored with a SPD-20A UV-Vis detector on 210 – 400 nm wavelength at ambient temperature and flow rate of 1 ml/min. The mobile phase was phosphate buffer: acetonitrile (75:25) and pH 2.5 adjusted with dilute ortho-phosphoric acid. The retention time of AMB and NAC were found to be 8.4024 and 3.35088 respectivelythe resolution was 9.86346. The method was mean recoveries in the range of 100.4 to 100.15 for all components. The developed method can be use for the routine analysis of AMB and NAC in tablet dosage form.
{"title":"Development and Validation Method for Simultaneous Investigation of Ambroxol Hydrochloride and N-Acetyl Cysteine In Bulk And Pharmaceutical Formulation By RP-HPLC.","authors":"Lokesh T. Thote, D. Dhabarde, J. Baheti, S. Borkar, Swati Bhusari","doi":"10.22270/ajprd.v10i6.1188","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1188","url":null,"abstract":"A simple, precise and rapid reverse phase HPLC- SPD 20-Amethod has been developed and validated for the simultaneous investigation of Ambroxol Hydrochloride (AMB) and N-Acetyl Cysteine (NAC) in tablet dosage form. The mixture of (AMB) and (NAC) was separated on C18 5µm.column (4.5 µm × 25 cm). All separation were monitored with a SPD-20A UV-Vis detector on 210 – 400 nm wavelength at ambient temperature and flow rate of 1 ml/min. The mobile phase was phosphate buffer: acetonitrile (75:25) and pH 2.5 adjusted with dilute ortho-phosphoric acid. The retention time of AMB and NAC were found to be 8.4024 and 3.35088 respectivelythe resolution was 9.86346. The method was mean recoveries in the range of 100.4 to 100.15 for all components. The developed method can be use for the routine analysis of AMB and NAC in tablet dosage form. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83487858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1185
S. Gogate, Rahul Mathur, Arpit Raghuvanshi, A. Yadav, Deepa Dhurve, Dheeraj Kumar Sen, D. Raj, J. Rathi
The present work can serve as a valuable source of information and provide appropriate standards to establish the quality of this plant material in future prospective study. From the results it is evident that the bark and leaves of Saraca indica contain a significant amount of phytochemicals viz. alkaloid, flavonoids, phenolic, saponins and tannin. The bark of Saraca indica contained relativelely higher amounts of phytochemicals than leaves. The comparative analysis of phytochemicals viz. total alkaloids, flavonoids, phenols, saponins and tannins in different solvent extracts from bark and leaves of Saraca indica
{"title":"Qualitative and Quantitative Screening of Phytochemicals in Polar and Non Polar Solvent Extracts of Stem Bark and Leaves of Saraca Indica","authors":"S. Gogate, Rahul Mathur, Arpit Raghuvanshi, A. Yadav, Deepa Dhurve, Dheeraj Kumar Sen, D. Raj, J. Rathi","doi":"10.22270/ajprd.v10i6.1185","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1185","url":null,"abstract":"The present work can serve as a valuable source of information and provide appropriate standards to establish the quality of this plant material in future prospective study. From the results it is evident that the bark and leaves of Saraca indica contain a significant amount of phytochemicals viz. alkaloid, flavonoids, phenolic, saponins and tannin. The bark of Saraca indica contained relativelely higher amounts of phytochemicals than leaves. The comparative analysis of phytochemicals viz. total alkaloids, flavonoids, phenols, saponins and tannins in different solvent extracts from bark and leaves of Saraca indica \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90269381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1186
S. Gogate, R. Mathur, Adarsh Mathur, Adarsh Hukre, Abdur Rehman, Afzal Hussain, J. Rathi
The objective of this study was estimate of Caffeine in Different Marketed Samples of Tea Although there were no significant differences between the orders of caffeine content among the tested tea brands, the method with chloroform isolation exhibited significantly lower results and the highest results obtained by the micromethod using H2SO4 at 273 nm UV wavelength with regard to other methods applied for the determination of caffeine. The non-laborious chemical method of determination of caffeine in tea samples using Lead oxide and Chloroform has shown us the caffeine levels in various samples. It is also true that caffeine in tea can have positive and negative effects on the organism consuming it.
{"title":"Estimation of Caffeine in Different Marketed Samples of Tea","authors":"S. Gogate, R. Mathur, Adarsh Mathur, Adarsh Hukre, Abdur Rehman, Afzal Hussain, J. Rathi","doi":"10.22270/ajprd.v10i6.1186","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1186","url":null,"abstract":"The objective of this study was estimate of Caffeine in Different Marketed Samples of Tea Although there were no significant differences between the orders of caffeine content among the tested tea brands, the method with chloroform isolation exhibited significantly lower results and the highest results obtained by the micromethod using H2SO4 at 273 nm UV wavelength with regard to other methods applied for the determination of caffeine. The non-laborious chemical method of determination of caffeine in tea samples using Lead oxide and Chloroform has shown us the caffeine levels in various samples. It is also true that caffeine in tea can have positive and negative effects on the organism consuming it. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90954335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1187
Amtul Rafeh Mariya, Arshiya Mubeen Batool, Sri Praneeth Polamuri, Anupama Koneru, S. P. Srinivas Nayak
Background: One of the major outcomes of valvular heart disease have been chronic complications that in turn have led to the reduced quality of life of patients. These complications have indeed caused immense burden on the health care system and has led to increased mortality rate. Objective: To determine prevalence rate and to evaluate complications of valvular heart disease patients. Methods: This is a cross sectional-based study carried out in a single hospital in Hyderabad, India. The survey was carried out over a year in India. The source of data collection was through case sheets and lab reports. Results: Of the total 102 subjects, valvular diseases were more prevalent in the age group of 51-60 and females were found to be more affected than males. Complications were less or equal to no after the procedure of valve replacement was performed in patients with severe cases though some patients showed complications even after surgery, but were stable after a long time of monitoring. 1% of valve prolapse cases were seen and 3% deaths due to the disease. St.jude mechanical valve of different sizes, 19 EPR biological valve and aortic valve implants were majorly used for valve replacement procedure. Conclusion: The study concludes that valvular diseases are more prevalent in the age group 51-60, and females were more affected by valvular diseases than males. Hypertension and diabetes mellitus were found to be the major comorbidities in valvular heart disease patients.
{"title":"Prevalence and Evaluation of Complications in Valvular Heart Disease Patients In Tertiary Care Hospital","authors":"Amtul Rafeh Mariya, Arshiya Mubeen Batool, Sri Praneeth Polamuri, Anupama Koneru, S. P. Srinivas Nayak","doi":"10.22270/ajprd.v10i6.1187","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1187","url":null,"abstract":"Background: One of the major outcomes of valvular heart disease have been chronic complications that in turn have led to the reduced quality of life of patients. These complications have indeed caused immense burden on the health care system and has led to increased mortality rate. Objective: To determine prevalence rate and to evaluate complications of valvular heart disease patients. Methods: This is a cross sectional-based study carried out in a single hospital in Hyderabad, India. The survey was carried out over a year in India. The source of data collection was through case sheets and lab reports. Results: Of the total 102 subjects, valvular diseases were more prevalent in the age group of 51-60 and females were found to be more affected than males. Complications were less or equal to no after the procedure of valve replacement was performed in patients with severe cases though some patients showed complications even after surgery, but were stable after a long time of monitoring. 1% of valve prolapse cases were seen and 3% deaths due to the disease. St.jude mechanical valve of different sizes, 19 EPR biological valve and aortic valve implants were majorly used for valve replacement procedure. Conclusion: The study concludes that valvular diseases are more prevalent in the age group 51-60, and females were more affected by valvular diseases than males. Hypertension and diabetes mellitus were found to be the major comorbidities in valvular heart disease patients. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80697576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1202
Shaik Sameena, S. Shafi, Dhumal P.B
Pharmacovigilance (PV) is kind of a sunshade to clarify the processes for observance and evaluating Adverse Drug Reactions (ADRs) and it’s a key part of effective drug regulation systems, clinical follow and public health programs. Spontaneous news of ADRs could be an important part of PV & it becomes a major disadvantage in developing countries. Knowledge of PV might sort the thought for interventions aimed toward up news rates and decreasing ADRs. PV could be an important and integral part of clinical analysis & it jointly plays employment among the help system through observance and interaction of medication and there effects among the body. Nowadays in state, PV provides awareness relating to ADRs and this review provides knowledge relating to implementation for determination of current problems. India’s rising stage; there is heaps to be done and told, the sphere of PV, in ensuring that the safe implementation of the activities and work done is achieved. Their increasing kind of hospitalization of patients as a results of ADRs and it becomes a challenge to hunt out the precise cause, once a patient is treated with multiple medication at a similar time. PV helps in safe and convenient use of pharmaceutical medication. The foremost objective of PV is that the assessment of benefit-risk profile of drug for higher potency and safety in patients. This review explains the need of Pharmacovigilance in companies, its growth in various centuries and current standing among the country.
{"title":"Necessity, Importance, Future Aspects and Challenges of Pharmacovigilance","authors":"Shaik Sameena, S. Shafi, Dhumal P.B","doi":"10.22270/ajprd.v10i6.1202","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1202","url":null,"abstract":"Pharmacovigilance (PV) is kind of a sunshade to clarify the processes for observance and evaluating Adverse Drug Reactions (ADRs) and it’s a key part of effective drug regulation systems, clinical follow and public health programs. Spontaneous news of ADRs could be an important part of PV & it becomes a major disadvantage in developing countries. Knowledge of PV might sort the thought for interventions aimed toward up news rates and decreasing ADRs. PV could be an important and integral part of clinical analysis & it jointly plays employment among the help system through observance and interaction of medication and there effects among the body. Nowadays in state, PV provides awareness relating to ADRs and this review provides knowledge relating to implementation for determination of current problems. India’s rising stage; there is heaps to be done and told, the sphere of PV, in ensuring that the safe implementation of the activities and work done is achieved. Their increasing kind of hospitalization of patients as a results of ADRs and it becomes a challenge to hunt out the precise cause, once a patient is treated with multiple medication at a similar time. PV helps in safe and convenient use of pharmaceutical medication. The foremost objective of PV is that the assessment of benefit-risk profile of drug for higher potency and safety in patients. This review explains the need of Pharmacovigilance in companies, its growth in various centuries and current standing among the country. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78241784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1203
Bondan Palestin, S. Kholifah, ,. Y. D. Arna
An elderly group is a vulnerable group due to the aging process. The declining health conditions of the elderly have an impact on the increasing dependence of the elderly on family and society. The state of the elderly is healthy holistically and actively affects the productive elderly. Increasing productivity among the elderly is significant in reducing dependence on others. One of the efforts to increase productivity among the elderly is the empowerment process. This research consists of two stages, (1) analytical observational method and (2) Focus Group Discussion. researchers will follow up on the research by Productive Elderly Indicator Measuring Tool based on an android application. The results of the study showed that there was a significant effect of holistic health conditions on increasing ability with a coefficient value of 0.268 with a significance of 0.003 (p-value <0.05). A positive coefficient means that the more holistic health conditions, the greater the ability of the elderly. There is a significant effect of the active determinant on increasing ability with a coefficient value of 0.449 with a significance of 0.000 (p-value <0.05). The positive coefficient means that the more active determinants are, the greater the ability of the elderly. There is a significant effect of increasing the ability of productive elderly with a coefficient value of 0.720 with a significance of 0.000 (p-value <0.05). The positive coefficient means that the increasing ability of the elderly will increase productivity elderly.
{"title":"The Determinants of Active Aging for Improving Elderly Abilities","authors":"Bondan Palestin, S. Kholifah, ,. Y. D. Arna","doi":"10.22270/ajprd.v10i6.1203","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1203","url":null,"abstract":"An elderly group is a vulnerable group due to the aging process. The declining health conditions of the elderly have an impact on the increasing dependence of the elderly on family and society. The state of the elderly is healthy holistically and actively affects the productive elderly. Increasing productivity among the elderly is significant in reducing dependence on others. One of the efforts to increase productivity among the elderly is the empowerment process. This research consists of two stages, (1) analytical observational method and (2) Focus Group Discussion. researchers will follow up on the research by Productive Elderly Indicator Measuring Tool based on an android application. The results of the study showed that there was a significant effect of holistic health conditions on increasing ability with a coefficient value of 0.268 with a significance of 0.003 (p-value <0.05). A positive coefficient means that the more holistic health conditions, the greater the ability of the elderly. There is a significant effect of the active determinant on increasing ability with a coefficient value of 0.449 with a significance of 0.000 (p-value <0.05). The positive coefficient means that the more active determinants are, the greater the ability of the elderly. There is a significant effect of increasing the ability of productive elderly with a coefficient value of 0.720 with a significance of 0.000 (p-value <0.05). The positive coefficient means that the increasing ability of the elderly will increase productivity elderly. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87255957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1194
Luv Kush
The drugs target the pathological proteins for the pharmacological intervention through their vunerability of chemophoric and congate groups 1-3 at therapeutic level. They are essential for binding affinity, intrinsic efficacy and bioavailability. They are introduced in bioactive molecules by replacement of hydrogen atoms. They are implicated in SAR modifications and interactional participation with receptor or enzyme or target protein. The pharmacological influence of them is delineated here.
{"title":"Pharmacological Vunerability of Chemophoric Groups","authors":"Luv Kush","doi":"10.22270/ajprd.v10i6.1194","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1194","url":null,"abstract":"The drugs target the pathological proteins for the pharmacological intervention through their vunerability of chemophoric and congate groups 1-3 at therapeutic level. They are essential for binding affinity, intrinsic efficacy and bioavailability. They are introduced in bioactive molecules by replacement of hydrogen atoms. They are implicated in SAR modifications and interactional participation with receptor or enzyme or target protein. The pharmacological influence of them is delineated here. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86777910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1204
Prasad Galande, V. Yadav, S. Borkar
Small sphere-shaped particles are known as microspheres and their particle size range is 1micrometer to 1000 micrometer. They are free-moving, spherical particles that can be manufactured from proteins or artificial polymers. There are several methods for delivering a medicinal chemical to the target region with a regulated, prolonged release. which naturally decomposes.Microcapsules and micromatricesare two of the different types of microspheres. There are numerous varieties of microspheres that are described. Microspheres are one of the most popular varieties and provide a number of benefits.Theseprepared microspheres can be compressed or filled with a firm gelatin. There are several methods for creating microspheres, including single-emulsion, double-emulsion, solvent evaporation, phase separation coacervation, and spray drying. Microspheres are assessed using a variety of assessment methods, and they are examined in relation to a number of applications, including the delivery of vaccines, chemotherapy, ophthalmic drugs, gene therapies, and oral, nasal, and buccal drug delivery of pharmaceuticals.
{"title":"A Review on Microspheres: Preparation, Characterization and Applications","authors":"Prasad Galande, V. Yadav, S. Borkar","doi":"10.22270/ajprd.v10i6.1204","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1204","url":null,"abstract":"Small sphere-shaped particles are known as microspheres and their particle size range is 1micrometer to 1000 micrometer. They are free-moving, spherical particles that can be manufactured from proteins or artificial polymers. There are several methods for delivering a medicinal chemical to the target region with a regulated, prolonged release. which naturally decomposes.Microcapsules and micromatricesare two of the different types of microspheres. There are numerous varieties of microspheres that are described. Microspheres are one of the most popular varieties and provide a number of benefits.Theseprepared microspheres can be compressed or filled with a firm gelatin. There are several methods for creating microspheres, including single-emulsion, double-emulsion, solvent evaporation, phase separation coacervation, and spray drying. Microspheres are assessed using a variety of assessment methods, and they are examined in relation to a number of applications, including the delivery of vaccines, chemotherapy, ophthalmic drugs, gene therapies, and oral, nasal, and buccal drug delivery of pharmaceuticals. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89293494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1205
Nikhil Dhumal, V. Yadav, S. Borkar
A dispersed nano-system with droplet sizes as small as submicrons is called a nanoemulsion. Nanoemulsions are thermodynamically stable, transparent, isotropic liquid mixtures of oil, water, surfactant, and co-surfactant. Nanoemulsion typically has droplet sizes between 20 and 200 nanometer. The size and composition of the scattered particles in a continuous phase are the primary distinctions between an emulsion and a nanoemulsion. This approach is intended to alleviate some of the issues that low bioavailability and noncompliance, two issues with traditional drug delivery systems, bring up.Today, nano emulsion can be created for a number of administration routes. A nano emulsion formulation can be considered an effective, secure, and patient-compliant pharmaceutical delivery method. Nowadays, nano emulsions have attracted a lot of interest in pharmacotherapy, dosage form design, and research. A surfactant and a cosurfactant can preserves the stability components of nanoemulsion. Brief details on the types, preparation process, stability, assessment, and applications of nanoemulsion are provided in this review.
{"title":"Nanoemulsion as Novel Drug Delivery System: Development, Characterization and Application","authors":"Nikhil Dhumal, V. Yadav, S. Borkar","doi":"10.22270/ajprd.v10i6.1205","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1205","url":null,"abstract":"A dispersed nano-system with droplet sizes as small as submicrons is called a nanoemulsion. Nanoemulsions are thermodynamically stable, transparent, isotropic liquid mixtures of oil, water, surfactant, and co-surfactant. Nanoemulsion typically has droplet sizes between 20 and 200 nanometer. The size and composition of the scattered particles in a continuous phase are the primary distinctions between an emulsion and a nanoemulsion. This approach is intended to alleviate some of the issues that low bioavailability and noncompliance, two issues with traditional drug delivery systems, bring up.Today, nano emulsion can be created for a number of administration routes. A nano emulsion formulation can be considered an effective, secure, and patient-compliant pharmaceutical delivery method. Nowadays, nano emulsions have attracted a lot of interest in pharmacotherapy, dosage form design, and research. A surfactant and a cosurfactant can preserves the stability components of nanoemulsion. Brief details on the types, preparation process, stability, assessment, and applications of nanoemulsion are provided in this review. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74396788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1191
Song Wenhao, Wang Quanwei, Fu Wenwen, Zhang Ce, Wang Tian
Topical herbal formulations are gaining more attention in wound healing due to their safety and efficacy. This is a systematic review of the effects of Curcuma longatopical formulations on wound healing. C. longa is a traditional medicinal plant used due to its antimicrobial, antioxidant, anti-inflammatory, and wound healing properties. Studies carried outas randomized control trials and clinical trials were included for the analysis of this review. Searches were conducted in PubMed, Scopus, Cochrane Central Register of Controlled Trials, and Google scholar (up to March 2022) with 04 studies meeting the inclusion criteria. All randomized control trials and clinical trials have shown a significant improvement in wound healing. The topical formulations containing C. longa as an ingredient have reportedly improved wound healing in cases of eczema, radiodermatitis, acne vulgaris, atopic dermatitis, ichthyosis vulgaris, senile pruritis, and xerotic skin conditions, according to the studies covered in this review.This review identified some evidence that C. longa extract has good effects for wound healing, in accordance with its use in traditional medicine. To evaluate the impact of C. longa on wound healing, including complications, larger, well-designed randomized control trials are required.
局部草药制剂由于其安全性和有效性在伤口愈合中越来越受到关注。这是一个系统的审查效果姜黄长鼻制剂对伤口愈合。龙舌兰是一种传统的药用植物，因为它具有抗菌、抗氧化、抗炎和伤口愈合的特性。随机对照试验和临床试验纳入了本综述的分析。在PubMed、Scopus、Cochrane Central Register of Controlled Trials和Google scholar中进行检索(截至2022年3月)，有04项研究符合纳入标准。所有随机对照试验和临床试验均显示伤口愈合有显著改善。根据本综述所涵盖的研究，含有龙舌兰作为成分的局部配方据报道可改善湿疹、放射性皮炎、寻常痤疮、特应性皮炎、寻常鱼鳞病、老年性瘙痒和干燥皮肤病的伤口愈合。本综述确定了一些证据，表明龙骨草提取物具有良好的伤口愈合效果，符合其在传统医学中的应用。为了评估长梭菌对伤口愈合的影响，包括并发症，需要更大规模、设计良好的随机对照试验。
{"title":"The Role of Ginsenosides in Myocardial Ischemic Injury-A Systematic Review","authors":"Song Wenhao, Wang Quanwei, Fu Wenwen, Zhang Ce, Wang Tian","doi":"10.22270/ajprd.v10i6.1191","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1191","url":null,"abstract":"Topical herbal formulations are gaining more attention in wound healing due to their safety and efficacy. This is a systematic review of the effects of Curcuma longatopical formulations on wound healing. C. longa is a traditional medicinal plant used due to its antimicrobial, antioxidant, anti-inflammatory, and wound healing properties. Studies carried outas randomized control trials and clinical trials were included for the analysis of this review. Searches were conducted in PubMed, Scopus, Cochrane Central Register of Controlled Trials, and Google scholar (up to March 2022) with 04 studies meeting the inclusion criteria. All randomized control trials and clinical trials have shown a significant improvement in wound healing. The topical formulations containing C. longa as an ingredient have reportedly improved wound healing in cases of eczema, radiodermatitis, acne vulgaris, atopic dermatitis, ichthyosis vulgaris, senile pruritis, and xerotic skin conditions, according to the studies covered in this review.This review identified some evidence that C. longa extract has good effects for wound healing, in accordance with its use in traditional medicine. To evaluate the impact of C. longa on wound healing, including complications, larger, well-designed randomized control trials are required. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82294741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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