Pub Date : 2020-09-01DOI: 10.31024/ajpp.2020.6.4.2
L. Perumal
{"title":"Bioactive compound isolated from marine Bacillus safensis MB8 and their cytotoxicity potential","authors":"L. Perumal","doi":"10.31024/ajpp.2020.6.4.2","DOIUrl":"https://doi.org/10.31024/ajpp.2020.6.4.2","url":null,"abstract":"","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81678655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.31024/ajpp.2020.6.4.4
F. Ahmed, Dalyathamer Ahmed
{"title":"Clinical manifestations and maternal outcomes of COVID-19 in pregnancy: A systematic review","authors":"F. Ahmed, Dalyathamer Ahmed","doi":"10.31024/ajpp.2020.6.4.4","DOIUrl":"https://doi.org/10.31024/ajpp.2020.6.4.4","url":null,"abstract":"","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83869198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.31024/ajpp.2020.6.4.7
P. Balaji, Mounika Kamsali, Anusha Kamsali
{"title":"Approach on design, synthesis and evaluation of Pharmacophore Benzothiazepine form substituted Chalcones","authors":"P. Balaji, Mounika Kamsali, Anusha Kamsali","doi":"10.31024/ajpp.2020.6.4.7","DOIUrl":"https://doi.org/10.31024/ajpp.2020.6.4.7","url":null,"abstract":"","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73157728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.31024/ajpp.2020.6.4.3
Harshada Lanjekar, S. Kolhe, S. Tembhurne
{"title":"Pharmacological evaluation of clove oil emulsion on propylthiouracil induced hypothyroidism in wistar rats","authors":"Harshada Lanjekar, S. Kolhe, S. Tembhurne","doi":"10.31024/ajpp.2020.6.4.3","DOIUrl":"https://doi.org/10.31024/ajpp.2020.6.4.3","url":null,"abstract":"","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84462887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.31024/ajpp.2020.6.4.6
Rupsana Perven Borsha, R. Islam, Md. Bazlar Rashid, F. Aziz, Md. Nazrul Islam, M. Hasan
{"title":"Study of steroid induced hyperglycemia against traditional hypoglycemic plant extracts in rat model","authors":"Rupsana Perven Borsha, R. Islam, Md. Bazlar Rashid, F. Aziz, Md. Nazrul Islam, M. Hasan","doi":"10.31024/ajpp.2020.6.4.6","DOIUrl":"https://doi.org/10.31024/ajpp.2020.6.4.6","url":null,"abstract":"","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89655481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.31024/ajpp.2020.6.4.8
S. Mohammed, A. L. Jasim
{"title":"Genetic polymorphisms associated with diabetic foot ulcer: A review article","authors":"S. Mohammed, A. L. Jasim","doi":"10.31024/ajpp.2020.6.4.8","DOIUrl":"https://doi.org/10.31024/ajpp.2020.6.4.8","url":null,"abstract":"","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89152409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-28DOI: 10.22541/au.159863540.09590441
A. Habib
{"title":"An examination into the function of pannexin in noradrenaline induced vasoconstriction in porcine splenic artery","authors":"A. Habib","doi":"10.22541/au.159863540.09590441","DOIUrl":"https://doi.org/10.22541/au.159863540.09590441","url":null,"abstract":"","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83688601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.31024/AJPP.2020.6.6.7
Reetu Yadav, Ashutosh Yadav, Anita Singh
Co-crystal is defined as a material which contains two or more discrete molecular entities in the crystal structure. Co-crystals of many compounds are known for years in solid state chemistry. However, it is only recently that pharmaceutical cocrystals have generated much commercial and academic interest. Pharmaceutical cocrystals are important because they can improve many properties of the parent API like solubility, dissolution rate, stability, crystallinity and many more (Almarsson and Zaworotko, 2004). Biopharmaceutics Classification System (BCS) of drugs classifies drugs into four major categories based on their solubility and permeability behavior. BCS Class II and Class IV drugs suffer from poor aqueous solubility. Poor aqueous solubility of hydrophobic drugs can result in poor absorption, low bioavailability and poses challenges for drug development process (Desiraju, 2003a). Enhancing bioavailability of poorly water-soluble BCS class II and BCS class IV drugs therefore becomes necessary to improve drug's efficacy. Co-crystallization enhances solubility of BCS class II and class IV drug. In addition to BCS of drugs, Developability Classification System (DCS) of drugs also plays a significant role in determining the development of pharmaceutical formulations, especially the oral formulations based on its solubility in biorelevant media such as FaSSIF (Fast State Simulated Intestinal Fluid) and FeSSIF (Fed State Simulated Intestinal Fluid) rather than its solubility in buffers (Dunitz, 2003b; Jain and Patel, 2015; Vadher et al., 2009). Very few reports are available in the literature where researchers have determined the dissolution rate of cocrystals of poorly water-soluble drugs in biorelevant media. The studies illustrate that cocrystals exhibited enhanced dissolution rate in biorelevant media and buffer as well indicating that the DCS serves as a highly relevant tool in determining develop ability of cocrystals of poorly water-soluble APIs. Enhancing aqueous solubility of poorly water-soluble drugs without compromising on stability is one of the major challenges faced by the pharmaceutical industries during drug discovery and development processes (Steed, 2013). Crystal Engineering is a tool which can be used to tailor the physicochemical properties of Active Pharmaceutical Ingredients (APIs) such as melting point, dissolution rate, aqueous solubility, refractive index, surface activity, habit, density, electrostatic, mechanical and optical properties. Cocrystallization is one of Co-crystal: A pharmaceutical technique to improve physical characteristics of Active Pharmaceutical Ingredient Reetu Yadav *, Ashutosh Kumar Yadav , Anita Singh 1 1 2
共晶是指在晶体结构中包含两个或两个以上离散分子实体的材料。许多化合物的共晶在固态化学中已被发现多年。然而，直到最近，药用共晶才引起了商业和学术上的极大兴趣。药用共晶很重要，因为它们可以改善母体原料药的许多特性，如溶解度、溶解速度、稳定性、结晶度等(Almarsson和Zaworotko, 2004)。生物制药药物分类系统(BCS)根据药物的溶解度和渗透性将药物分为四大类。BCS II类和IV类药物水溶性差。疏水药物的水溶性差会导致吸收不良，生物利用度低，给药物开发过程带来挑战(Desiraju, 2003a)。因此，提高水溶性差的BCS II类和BCS IV类药物的生物利用度是提高药物疗效的必要条件。共结晶提高了BCS II类和IV类药物的溶解度。除了药物的BCS之外，药物的可开发性分类系统(DCS)在决定药物制剂的发展方面也起着重要作用，特别是基于其在生物相关介质(如FaSSIF (Fast State simulation肠液)和FeSSIF (Fed State simulation肠液)中的溶解度而不是其在缓冲液中的溶解度的口服制剂(Dunitz, 2003b;Jain and Patel, 2015;Vadher et al.， 2009)。文献中很少有研究人员测定水溶性差的药物的共晶在生物相关介质中的溶出率的报道。研究表明，共晶在生物相关介质和缓冲液中的溶解速率也有所提高，这表明DCS在确定水溶性差的原料药共晶的显影能力方面是一个高度相关的工具。在不影响稳定性的情况下提高水溶性差药物的水溶性是制药行业在药物发现和开发过程中面临的主要挑战之一(Steed, 2013)。晶体工程是一种可用于定制活性药物成分(api)的物理化学性质的工具，如熔点、溶解速度、水溶性、折射率、表面活性、习性、密度、静电、机械和光学性质。Reetu Yadav *， Ashutosh Kumar Yadav, Anita Singh 1 1 2 .共结晶是共晶之一:一种改善活性药物成分物理特性的药学技术
{"title":"Co-crystal: A pharmaceutical technique to improve physical characteristics of Active Pharmaceutical Ingredient","authors":"Reetu Yadav, Ashutosh Yadav, Anita Singh","doi":"10.31024/AJPP.2020.6.6.7","DOIUrl":"https://doi.org/10.31024/AJPP.2020.6.6.7","url":null,"abstract":"Co-crystal is defined as a material which contains two or more discrete molecular entities in the crystal structure. Co-crystals of many compounds are known for years in solid state chemistry. However, it is only recently that pharmaceutical cocrystals have generated much commercial and academic interest. Pharmaceutical cocrystals are important because they can improve many properties of the parent API like solubility, dissolution rate, stability, crystallinity and many more (Almarsson and Zaworotko, 2004). Biopharmaceutics Classification System (BCS) of drugs classifies drugs into four major categories based on their solubility and permeability behavior. BCS Class II and Class IV drugs suffer from poor aqueous solubility. Poor aqueous solubility of hydrophobic drugs can result in poor absorption, low bioavailability and poses challenges for drug development process (Desiraju, 2003a). Enhancing bioavailability of poorly water-soluble BCS class II and BCS class IV drugs therefore becomes necessary to improve drug's efficacy. Co-crystallization enhances solubility of BCS class II and class IV drug. In addition to BCS of drugs, Developability Classification System (DCS) of drugs also plays a significant role in determining the development of pharmaceutical formulations, especially the oral formulations based on its solubility in biorelevant media such as FaSSIF (Fast State Simulated Intestinal Fluid) and FeSSIF (Fed State Simulated Intestinal Fluid) rather than its solubility in buffers (Dunitz, 2003b; Jain and Patel, 2015; Vadher et al., 2009). Very few reports are available in the literature where researchers have determined the dissolution rate of cocrystals of poorly water-soluble drugs in biorelevant media. The studies illustrate that cocrystals exhibited enhanced dissolution rate in biorelevant media and buffer as well indicating that the DCS serves as a highly relevant tool in determining develop ability of cocrystals of poorly water-soluble APIs. Enhancing aqueous solubility of poorly water-soluble drugs without compromising on stability is one of the major challenges faced by the pharmaceutical industries during drug discovery and development processes (Steed, 2013). Crystal Engineering is a tool which can be used to tailor the physicochemical properties of Active Pharmaceutical Ingredients (APIs) such as melting point, dissolution rate, aqueous solubility, refractive index, surface activity, habit, density, electrostatic, mechanical and optical properties. Cocrystallization is one of Co-crystal: A pharmaceutical technique to improve physical characteristics of Active Pharmaceutical Ingredient Reetu Yadav *, Ashutosh Kumar Yadav , Anita Singh 1 1 2","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78983041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.31024/AJPP.2020.6.6.2
E. Ngounou, F. Dongmo, Y. D. Mang, Slestin Sokeng Dongmo, N. N. Yanou
Paracelsus (1493-1541) reported that all substances are poisons, only the right dose can distinguish a poison from a drug. Toxicity is the intrinsic ability of a chemical or physical agent to have a harmful effect on an organism. It is the capacity specific to various substances whose absorption of single or repeated doses has the effect of disturbing the metabolism of living beings, causing physiological disorders which can go as far as the death of exposed individuals (Ramade, 2002). According to Stéphane Malard (2018), the harmful effect is any alteration due to treatment deviating from normality taken as a reference, which reduces the ability of an organism to survive, reproduce or adapt to the environment.
{"title":"Evaluation of the acute and subchronic toxicity of the aqueous extract of the leaves of Clerodendrum thomsoniae Linn in oral route","authors":"E. Ngounou, F. Dongmo, Y. D. Mang, Slestin Sokeng Dongmo, N. N. Yanou","doi":"10.31024/AJPP.2020.6.6.2","DOIUrl":"https://doi.org/10.31024/AJPP.2020.6.6.2","url":null,"abstract":"Paracelsus (1493-1541) reported that all substances are poisons, only the right dose can distinguish a poison from a drug. Toxicity is the intrinsic ability of a chemical or physical agent to have a harmful effect on an organism. It is the capacity specific to various substances whose absorption of single or repeated doses has the effect of disturbing the metabolism of living beings, causing physiological disorders which can go as far as the death of exposed individuals (Ramade, 2002). According to Stéphane Malard (2018), the harmful effect is any alteration due to treatment deviating from normality taken as a reference, which reduces the ability of an organism to survive, reproduce or adapt to the environment.","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77663407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.31024/ajpp.2020.6.2.10
Shweta S. Mishra, R. Dahima
{"title":"Designing of wonder molecule for a polygenic disease: Diabetes Mellitus","authors":"Shweta S. Mishra, R. Dahima","doi":"10.31024/ajpp.2020.6.2.10","DOIUrl":"https://doi.org/10.31024/ajpp.2020.6.2.10","url":null,"abstract":"","PeriodicalId":8538,"journal":{"name":"Asian Journal of Pharmacy and Pharmacology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77144134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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