Pub Date : 2023-06-28DOI: 10.52711/0974-4150.2023.00031
Fatiha Mebarki, Souhaila Meneceur, N. Ziani, Khadidja Amirat, Abderrhmane Bouafia
To assess the relative toxicity of a mixed series of 21(linear and branched-chain) alcohols and 9 normal aliphatic amines in terms of the 50% inhibitory growth concentration (IGC50) of Tetrahymena Pyriformis, a Quantitative Modeling study know as a Structure-Activity/property/Toxicity Relationship (QSAR/QSPR/QSTR) was conducted (20 training,10 tests). The used least squares LS method has been using MINITAB 16 Software and nom-parametric estimation (least absolute deviation LAD) (robust regression method) has been using Calculation Programs by MATLAB Software. The applied simple linear regression approach is based on theoretical H4p (GETAWAY descriptor) molecular descriptor from DRAGON software The performance of regression is better if the distribution of errors has normal, in this case we use the least squares LS method for statistical analysis. When the data does not have a natural assumption, we move to another method of analysis that is more robust and more frequent for the presence of the points of articulation, which is the least absolut deviation method (LAD). The findings of statistical analysis for the chosen model (QSAR) using simple linear Regression using the least Squares Method were R^2=97.39% ,Q^2=96.69% ,Q_bOOT^2=96.24%,Q_EXT^2=93.91% ,R_adj^2=97.24%, S=0.248 Anderson Darling (AD) test =1.57 >0.752 , symmetry coefficient (ou skeweness) (sk= 2.14>0 ) , flatness coefficient (Kurtosis) (ku=5.75>3) and Jarque and Bera Test (JB= 42.84>5.9942. the results did not follow the normal law (unnormal). The coefficient of determination and the value of standard deviation are both highly sensitive to the presence of aberrant compounds(abnormales), as the R^2value moved from 87, 96 % to 94.18 %, which increased by a value of 6.22% and the value of standard deviation (S) moved from 0.399 to 0.303, it increased by a value of 25 % after removing aberrant compound (abnormalie) are interpreted as better adjustment and they are positively. After removing the aberrant compound, we did not see any change in the lines coefficients, indicatting that the function’s graph is stable, demonstrating the LAD method and increased power, which are unaffected by the presence of aberrant compounds Consequently, which means that the model of one descriptor selected is good and statistically strong, Three influential compounds detected ((one compound of training, two compounds of Test) and important the model and absence of studied sample aberrants compounds.
{"title":"Modeling of Inhibition of Tetrahymena pyriformis growth by Aliphatic Alcohols and Amines pollution of l’ environmental","authors":"Fatiha Mebarki, Souhaila Meneceur, N. Ziani, Khadidja Amirat, Abderrhmane Bouafia","doi":"10.52711/0974-4150.2023.00031","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00031","url":null,"abstract":"To assess the relative toxicity of a mixed series of 21(linear and branched-chain) alcohols and 9 normal aliphatic amines in terms of the 50% inhibitory growth concentration (IGC50) of Tetrahymena Pyriformis, a Quantitative Modeling study know as a Structure-Activity/property/Toxicity Relationship (QSAR/QSPR/QSTR) was conducted (20 training,10 tests). The used least squares LS method has been using MINITAB 16 Software and nom-parametric estimation (least absolute deviation LAD) (robust regression method) has been using Calculation Programs by MATLAB Software. The applied simple linear regression approach is based on theoretical H4p (GETAWAY descriptor) molecular descriptor from DRAGON software The performance of regression is better if the distribution of errors has normal, in this case we use the least squares LS method for statistical analysis. When the data does not have a natural assumption, we move to another method of analysis that is more robust and more frequent for the presence of the points of articulation, which is the least absolut deviation method (LAD). The findings of statistical analysis for the chosen model (QSAR) using simple linear Regression using the least Squares Method were R^2=97.39% ,Q^2=96.69% ,Q_bOOT^2=96.24%,Q_EXT^2=93.91% ,R_adj^2=97.24%, S=0.248 Anderson Darling (AD) test =1.57 >0.752 , symmetry coefficient (ou skeweness) (sk= 2.14>0 ) , flatness coefficient (Kurtosis) (ku=5.75>3) and Jarque and Bera Test (JB= 42.84>5.9942. the results did not follow the normal law (unnormal). The coefficient of determination and the value of standard deviation are both highly sensitive to the presence of aberrant compounds(abnormales), as the R^2value moved from 87, 96 % to 94.18 %, which increased by a value of 6.22% and the value of standard deviation (S) moved from 0.399 to 0.303, it increased by a value of 25 % after removing aberrant compound (abnormalie) are interpreted as better adjustment and they are positively. After removing the aberrant compound, we did not see any change in the lines coefficients, indicatting that the function’s graph is stable, demonstrating the LAD method and increased power, which are unaffected by the presence of aberrant compounds Consequently, which means that the model of one descriptor selected is good and statistically strong, Three influential compounds detected ((one compound of training, two compounds of Test) and important the model and absence of studied sample aberrants compounds.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91060921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.52711/0974-4150.2023.00035
Dr. Ravi Varala, Sudhakar Madhavedi
Earlier than shielding the entire world from Covid-19, another crisis is looming around the globe due to the Monkeypox virus (MPXV). In recent times, the sudden rise of Monkeypox (MPX) epidemic cases is now a cause of concern for countries around the globe. Globally, the number of new weekly cases fell by 5% from November 14 to November 20, 2022. More than 62,000 confirmed cases have been reported to WHO from 105 countries and territories since the outbreak began few months ago, along with 23 fatalities. The current outbreak primarily affects guys who have sex with other men and is disseminated primarily via sexual contact. "Just because a condition like monkeypox seems manageable does not guarantee it will remain manageable." The poor dissimilation of knowledge about viral zoonosis, disease investigation, and scientific research about MPX outbreaks can deteriorate the current situation into a deep crisis in the near future. Hence, the present case study focuses on the origin, detection, investigation, prevention, and therapeutic measures of MPX disease in the rising situation of cases. In addition, it proposes various public health measures, policy actions to prevent the transmission of the virus, medical support, and scaling up infrastructure, which are the desperate needs of the hour.
{"title":"Looming another global crisis-Monkeypox: Plan of action for third world countries","authors":"Dr. Ravi Varala, Sudhakar Madhavedi","doi":"10.52711/0974-4150.2023.00035","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00035","url":null,"abstract":"Earlier than shielding the entire world from Covid-19, another crisis is looming around the globe due to the Monkeypox virus (MPXV). In recent times, the sudden rise of Monkeypox (MPX) epidemic cases is now a cause of concern for countries around the globe. Globally, the number of new weekly cases fell by 5% from November 14 to November 20, 2022. More than 62,000 confirmed cases have been reported to WHO from 105 countries and territories since the outbreak began few months ago, along with 23 fatalities. The current outbreak primarily affects guys who have sex with other men and is disseminated primarily via sexual contact. \"Just because a condition like monkeypox seems manageable does not guarantee it will remain manageable.\" The poor dissimilation of knowledge about viral zoonosis, disease investigation, and scientific research about MPX outbreaks can deteriorate the current situation into a deep crisis in the near future. Hence, the present case study focuses on the origin, detection, investigation, prevention, and therapeutic measures of MPX disease in the rising situation of cases. In addition, it proposes various public health measures, policy actions to prevent the transmission of the virus, medical support, and scaling up infrastructure, which are the desperate needs of the hour.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74997379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.52711/0974-4150.2023.00033
Husnain Fathima, Mahboob Pasha, Mohamed Khaleel
A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Finerenone in pure drug and tablet dosage form. The absorbance was measured at 239.8nm using Ethanol as solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml with coefficient of correlation (r2) of 0.997. Limit of detection (LOD) was found to be 1.220µg/ml and Limit of quantitation (LOQ) was found to be 5.220µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.
{"title":"Estimation and Validation of Finerenone in Dosage Form and in Bulk Drug by Spectrophotometric Method","authors":"Husnain Fathima, Mahboob Pasha, Mohamed Khaleel","doi":"10.52711/0974-4150.2023.00033","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00033","url":null,"abstract":"A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Finerenone in pure drug and tablet dosage form. The absorbance was measured at 239.8nm using Ethanol as solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml with coefficient of correlation (r2) of 0.997. Limit of detection (LOD) was found to be 1.220µg/ml and Limit of quantitation (LOQ) was found to be 5.220µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82143999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.52711/0974-4150.2023.00034
Koustubh Jagtap, Kiran Zinjurate, R. Ligade, R. Bhondwe
The current investigation is carried out to study stability of Diels-Alder adduct methyl 2-methoxycyclohex-3-ene-1 where (a) and (e) represent axial and equatorial orientation of group .The region-selective mechanism of Diels-Alder reaction between 1-methoxy 1,3butadiene (1) and methyl acrylate (2) to give methyl 2-methoxycyclohex-3-ene-1-carboxylate (3) is studied using Density Functional Theory (DFT). There are three possible stereo-chemical products possible for this reaction such as axial-axial (a,a), equatorial-equatorial (e,e) and axial-equatorial (a,e). Density Functional Theory was carried out to study the optimized molecular structure and the Potential Energy Surface (PES) Scan. The Frontier Molecular Orbital (FMO) energy calculations were carried out and HOMO LUMO energy gap was calculated to analyse the stability and reactivity. The Molecular Electrostatic Potential (MEP) study was carried out to analyse the surface of the molecule. FTIR spectra show the vibrational analysis of molecule.
{"title":"Density Functional Theory (DFT) Study of Methyl 2-methoxycyclohex-3-ene-1-carboxylate for structure optimization, transition state, vibrational, electronic and PES scan","authors":"Koustubh Jagtap, Kiran Zinjurate, R. Ligade, R. Bhondwe","doi":"10.52711/0974-4150.2023.00034","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00034","url":null,"abstract":"The current investigation is carried out to study stability of Diels-Alder adduct methyl 2-methoxycyclohex-3-ene-1 where (a) and (e) represent axial and equatorial orientation of group .The region-selective mechanism of Diels-Alder reaction between 1-methoxy 1,3butadiene (1) and methyl acrylate (2) to give methyl 2-methoxycyclohex-3-ene-1-carboxylate (3) is studied using Density Functional Theory (DFT). There are three possible stereo-chemical products possible for this reaction such as axial-axial (a,a), equatorial-equatorial (e,e) and axial-equatorial (a,e). Density Functional Theory was carried out to study the optimized molecular structure and the Potential Energy Surface (PES) Scan. The Frontier Molecular Orbital (FMO) energy calculations were carried out and HOMO LUMO energy gap was calculated to analyse the stability and reactivity. The Molecular Electrostatic Potential (MEP) study was carried out to analyse the surface of the molecule. FTIR spectra show the vibrational analysis of molecule.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81196910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.52711/0974-4150.2023.00038
Shiva Rama Krishna Samala, M. Surana, R. Sreenivasulu
Novel simple efficient hazardous free and cost-effective process for the synthesis of 2, 6-Difluoroniline. This compound is highly efficient Pharmaceutical intermediate and insecticide chemical. All the synthesized intermediates and target compound were characterized by NMR and mass analysis.
{"title":"A Novel Route of Synthesis of High Efficiency Pharmaceutical Intermediate and Insecticide Chemical 2, 6-Difluoroaniline","authors":"Shiva Rama Krishna Samala, M. Surana, R. Sreenivasulu","doi":"10.52711/0974-4150.2023.00038","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00038","url":null,"abstract":"Novel simple efficient hazardous free and cost-effective process for the synthesis of 2, 6-Difluoroniline. This compound is highly efficient Pharmaceutical intermediate and insecticide chemical. All the synthesized intermediates and target compound were characterized by NMR and mass analysis.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82690729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.52711/0974-4150.2023.00040
S. N, M. Vaidya, S. K. S., Susheel Kumar, A. Srivastava
Rasashastra offers superior health and disease prevention to mankind rather than being a science based on alchemical principles. It contains extensive descriptions of various metallic, mineral, and herbomineral formulations, but the majority of them have not yet been investigated by the ayurvedic community. Pottali Rasakalpas has many benefits like lowest drug dose requirement and excellent efficacy when compared to other Rasayogas, pottalikalpana is an untested, innovative drug form of Rasashastra. This study has been endeavored to gather the different techniques for planning of Pottalis in short and checked out to change Arogyavardhini Vati into Pottali structure.
{"title":"Arogyavardhini Pottali – A unique Dosage Form of Ayurveda","authors":"S. N, M. Vaidya, S. K. S., Susheel Kumar, A. Srivastava","doi":"10.52711/0974-4150.2023.00040","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00040","url":null,"abstract":"Rasashastra offers superior health and disease prevention to mankind rather than being a science based on alchemical principles. It contains extensive descriptions of various metallic, mineral, and herbomineral formulations, but the majority of them have not yet been investigated by the ayurvedic community. Pottali Rasakalpas has many benefits like lowest drug dose requirement and excellent efficacy when compared to other Rasayogas, pottalikalpana is an untested, innovative drug form of Rasashastra. This study has been endeavored to gather the different techniques for planning of Pottalis in short and checked out to change Arogyavardhini Vati into Pottali structure.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73596288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The goal of the current work was to explore the human organic cation uptake transporter and its critical function in biological transportation. The hOCT is extensively articulated in the liver and has been found to have a broad range of substrate selectivity, which is encoded by the SLC22A1 gene. OCT1 promotes molecular diffusion, enabling nutrients to enter the cell. OCT1 can aid in the absorption of drugs used to treat illnesses like cancer, according to recent research. Functionally impaired OCT1, whose appearance levels are associated with responses to a variety of medications, is the root cause of drug resistance. One of the important pharmacological targets employed in pharmacogenomic studies has recently been proposed as OCT1. The entire OCT1 gene contains a few single nucleotide polymorphisms. Also unknown are the specific changes or interactions with other proteins required for OCT1 to recognize a range of ligands. The authors presented the most recent OCT1 findings in this review to stimulate further investigation into this crucial uptake transporter.
{"title":"Human Organic Cation Transporter Use and Drug Target Responses","authors":"Badiginchala Navya Sai, Hindustan Abdul Ahad, Haranath Chinthaginjala, Bake Meharajunnisa, Siriguppa Dheeraj, Mallem Venkata Barath","doi":"10.52711/0974-4150.2023.00032","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00032","url":null,"abstract":"The goal of the current work was to explore the human organic cation uptake transporter and its critical function in biological transportation. The hOCT is extensively articulated in the liver and has been found to have a broad range of substrate selectivity, which is encoded by the SLC22A1 gene. OCT1 promotes molecular diffusion, enabling nutrients to enter the cell. OCT1 can aid in the absorption of drugs used to treat illnesses like cancer, according to recent research. Functionally impaired OCT1, whose appearance levels are associated with responses to a variety of medications, is the root cause of drug resistance. One of the important pharmacological targets employed in pharmacogenomic studies has recently been proposed as OCT1. The entire OCT1 gene contains a few single nucleotide polymorphisms. Also unknown are the specific changes or interactions with other proteins required for OCT1 to recognize a range of ligands. The authors presented the most recent OCT1 findings in this review to stimulate further investigation into this crucial uptake transporter.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74309192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-15DOI: 10.52711/0974-4150.2023.00028
J. Dontulwar, Anuja G. Kondalkar
The pharmaceutical cocrystals have sparked a lot of attention because of their ability to improve a drug’s physicochemical flaws, like poor water solubility. The amino carboxylic derivative of benzene was used to synthesized the benzocaine-based compounds which shows numerous biological activities. Here the mechanochemical solvent assisted grinding method were used to obtain the benzocaine-based co-crystals which is not reported yet before. The synthesized benzocain co-crystals were further analyzed using P-XRD and FTIR spectroscopic techniques. The shifting of IR peak from its individual compounds are clearly confirm the formation of co-crystal. From P-XRD analysis it is confirms that the benzocain compound and coformer shows different phase compare to its co-crystal which give the confirmation of co-crystal formation. The formation of co-crystals was further supported by taking their melting point which is completely different than pure component and its co-former. The Cambridge Structural Database (CSD) survey were used for structural analysis of reported benzocaine using mercury software. The crystal explorer software were used to calculate the percentage bond interactions in the reported benzocaine compound.
{"title":"Green approach towards Synthesis and Structural Analysis of benzocaine-based compound and its co-crystals","authors":"J. Dontulwar, Anuja G. Kondalkar","doi":"10.52711/0974-4150.2023.00028","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00028","url":null,"abstract":"The pharmaceutical cocrystals have sparked a lot of attention because of their ability to improve a drug’s physicochemical flaws, like poor water solubility. The amino carboxylic derivative of benzene was used to synthesized the benzocaine-based compounds which shows numerous biological activities. Here the mechanochemical solvent assisted grinding method were used to obtain the benzocaine-based co-crystals which is not reported yet before. The synthesized benzocain co-crystals were further analyzed using P-XRD and FTIR spectroscopic techniques. The shifting of IR peak from its individual compounds are clearly confirm the formation of co-crystal. From P-XRD analysis it is confirms that the benzocain compound and coformer shows different phase compare to its co-crystal which give the confirmation of co-crystal formation. The formation of co-crystals was further supported by taking their melting point which is completely different than pure component and its co-former. The Cambridge Structural Database (CSD) survey were used for structural analysis of reported benzocaine using mercury software. The crystal explorer software were used to calculate the percentage bond interactions in the reported benzocaine compound.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73043839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-15DOI: 10.52711/0974-4150.2023.00021
Latra Benkhira, N. Chaouch
Plants constitute a vital component of the biodiversity as they play a key role in maintaining earth’s environmental equilibrium and ecosystem stability. Herbal medicine is known to be the oldest form of healing, dating back to ancient Greece (1600 BC). It involves the use of plant to improve, maintain or restore health and wholeness. Phytochemicals are bioactive chemicals of plant origin. They are regarded as secondary metabolites synthesized in all parts of the plant body. The quantity and quality of phytochemicals present in plant parts may differ from one part to another. In fact, there is a lack of information on the distribution of the biological activity in different plant parts mainly due to the difference in distribution of active compounds which are more frequent in some plant parts than in others. Colocynthis vulgaris (L) Schrader is one of the medicinal plants of the Cucurbitaceae family, widespread in Algeria mainly in Ouargla in the region of Oued N'sa. This plant is used in traditional medicine for the treatment of several diseases. Its multiple pharmacological properties are due to its richness in active substances, especially alkaloids. The main objective of this study is the comparison between two extraction protocols of alkaloids, one in acid medium and the other in an alkaline medium. The results obtained confirm the plant's richness in alkaloids and the efficiency of the extraction protocol in acid medium.
{"title":"Extraction of Alkaloids from Colocynthis vulgaris (L.) Schrader harvested in Oued N’sa (Ouargla region)","authors":"Latra Benkhira, N. Chaouch","doi":"10.52711/0974-4150.2023.00021","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00021","url":null,"abstract":"Plants constitute a vital component of the biodiversity as they play a key role in maintaining earth’s environmental equilibrium and ecosystem stability. Herbal medicine is known to be the oldest form of healing, dating back to ancient Greece (1600 BC). It involves the use of plant to improve, maintain or restore health and wholeness. Phytochemicals are bioactive chemicals of plant origin. They are regarded as secondary metabolites synthesized in all parts of the plant body. The quantity and quality of phytochemicals present in plant parts may differ from one part to another. In fact, there is a lack of information on the distribution of the biological activity in different plant parts mainly due to the difference in distribution of active compounds which are more frequent in some plant parts than in others. Colocynthis vulgaris (L) Schrader is one of the medicinal plants of the Cucurbitaceae family, widespread in Algeria mainly in Ouargla in the region of Oued N'sa. This plant is used in traditional medicine for the treatment of several diseases. Its multiple pharmacological properties are due to its richness in active substances, especially alkaloids. The main objective of this study is the comparison between two extraction protocols of alkaloids, one in acid medium and the other in an alkaline medium. The results obtained confirm the plant's richness in alkaloids and the efficiency of the extraction protocol in acid medium.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84533071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-15DOI: 10.52711/0974-4150.2023.00030
Amol Pore, Sanjay Bais, Anjali Bhausaheb Sathe
With the increased realization that many wild medicinal and aromatic plant (MAP) Species are being over-exploited, a number of agencies are recommending that wild species be brought into cultivation systems. Others argue sustainable harvest to be the most important conservation strategy for most wild-harvested species, given their contributions to local economies and their greater value to harvesters over the long term. Besides poverty and the breakdown of traditional controls, the major challenges for sustainable wild-collection include lack of knowledge about sustainable harvest rates and practices, undefined land use rights and lack of legislative and policy guidance. Identifying the conservation benefits and costs of the different production system for MAP should help guide policies as whether species conservation should take place in nature or the nursery, or both.
{"title":"Commercial Cultivation and Collection Aspects of Medicinal and Aromatic Plants","authors":"Amol Pore, Sanjay Bais, Anjali Bhausaheb Sathe","doi":"10.52711/0974-4150.2023.00030","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00030","url":null,"abstract":"With the increased realization that many wild medicinal and aromatic plant (MAP) Species are being over-exploited, a number of agencies are recommending that wild species be brought into cultivation systems. Others argue sustainable harvest to be the most important conservation strategy for most wild-harvested species, given their contributions to local economies and their greater value to harvesters over the long term. Besides poverty and the breakdown of traditional controls, the major challenges for sustainable wild-collection include lack of knowledge about sustainable harvest rates and practices, undefined land use rights and lack of legislative and policy guidance. Identifying the conservation benefits and costs of the different production system for MAP should help guide policies as whether species conservation should take place in nature or the nursery, or both.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90559663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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