Pub Date : 2023-02-24DOI: 10.52711/0974-4150.2023.00012
R. Godge, Amol S Dighe, Piyusha Kolhe
In recent decades, many studies have been carried out on heterocycles, especially imidazole rings. The pharmacological properties such as antibacterial, antifungal, anticancer, antiviral and antidiabetic properties Apart from that, there are few side effects. The search for new biologically active imidazoles remains an area of interest An overview of medicinal chemistry. This white paper aims to collect and explain a wealth of information. Antibacterial profile of imidazole. Therefore, it can be used for future development to obtain new effective drug molecules. These heterocycles are important building blocks of functional molecules used in various fields. Used on a daily basis. Emphasis was placed on the bonds that form during the formation of imidazole. The usefulness of these methods is based on functional group compatibility. Processes around the ring and the resulting permutation patterns are described, including domain descriptions. Limitations, Reaction Mechanisms, and Future Challenges. The imidazole ring is part of several important natural products Products containing purines, histamine, histidine, nucleic acids. as polar and ionic Aromatic compounds that improve the pharmacokinetic properties of lead molecules Used as a remedy to optimize poorly proposed solubility and bioavailability parameters soluble lead molecule. Imidazole derivatives occupy a unique position in the art medicinal chemistry. Imidazole drugs have expanded the scope of eliminating various dispositions in clinics dose.
{"title":"An Overview of Imidazole, Derivatives Ofimidazole and its Pharmacological Applications","authors":"R. Godge, Amol S Dighe, Piyusha Kolhe","doi":"10.52711/0974-4150.2023.00012","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00012","url":null,"abstract":"In recent decades, many studies have been carried out on heterocycles, especially imidazole rings. The pharmacological properties such as antibacterial, antifungal, anticancer, antiviral and antidiabetic properties Apart from that, there are few side effects. The search for new biologically active imidazoles remains an area of interest An overview of medicinal chemistry. This white paper aims to collect and explain a wealth of information. Antibacterial profile of imidazole. Therefore, it can be used for future development to obtain new effective drug molecules. These heterocycles are important building blocks of functional molecules used in various fields. Used on a daily basis. Emphasis was placed on the bonds that form during the formation of imidazole. The usefulness of these methods is based on functional group compatibility. Processes around the ring and the resulting permutation patterns are described, including domain descriptions. Limitations, Reaction Mechanisms, and Future Challenges. The imidazole ring is part of several important natural products Products containing purines, histamine, histidine, nucleic acids. as polar and ionic Aromatic compounds that improve the pharmacokinetic properties of lead molecules Used as a remedy to optimize poorly proposed solubility and bioavailability parameters soluble lead molecule. Imidazole derivatives occupy a unique position in the art medicinal chemistry. Imidazole drugs have expanded the scope of eliminating various dispositions in clinics dose.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81704483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-24DOI: 10.52711/0974-4150.2023.00003
A. Saha, Sanjay Dhar Roy
Today we all take care very much about environment because it degrades day by day for several reasons; one of them is the accumulation of heavy metals which are one of the intrinsic components of this environment. The excessive accumulation of heavy metals affects all sides’ viz. air, soil, water of our beautiful environment through their adverse impacts. There are too many sources open till now for helping them to enter into the environment. This paper shows how they enter together and affects food chain, plant growth, seed germination, photosynthesis and so many. Excess accumulation of both types of heavy metals viz. essential (Zn, Cu, Fe etc) and non-essential (Pb, Hg, As etc) are responsible for disturbance of both aquatic as well as non-aquatic environment parallelly. Human beings also face slow but steady affect either direct or indirect way. So, we try to reflect how toxic level of heavy metals contamination poses a serious threat to our living environment.
{"title":"Harmful Effects of Different Classes of Heavy Metals in Our Beautiful Environment","authors":"A. Saha, Sanjay Dhar Roy","doi":"10.52711/0974-4150.2023.00003","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00003","url":null,"abstract":"Today we all take care very much about environment because it degrades day by day for several reasons; one of them is the accumulation of heavy metals which are one of the intrinsic components of this environment. The excessive accumulation of heavy metals affects all sides’ viz. air, soil, water of our beautiful environment through their adverse impacts. There are too many sources open till now for helping them to enter into the environment. This paper shows how they enter together and affects food chain, plant growth, seed germination, photosynthesis and so many. Excess accumulation of both types of heavy metals viz. essential (Zn, Cu, Fe etc) and non-essential (Pb, Hg, As etc) are responsible for disturbance of both aquatic as well as non-aquatic environment parallelly. Human beings also face slow but steady affect either direct or indirect way. So, we try to reflect how toxic level of heavy metals contamination poses a serious threat to our living environment.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81194695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-24DOI: 10.52711/0974-4150.2023.00007
Akanksha K. Mane, V. Chaware
Background: Every drug has the potentiality to cause an adverse drug reaction (ADR). ADRs are a major problem in drug therapy. The aim of this study was to assess the incidence and causality, severity and Preventability of ADRs Amlodipine (antihypertensive agents) used for the essential hypertensive patients during the time period of April 2022 to Jun 2022. Methods: This prospective-observational study was carried out in general medicine outpatient department in 15 Patients. Results: Out of 15 patients, 10 (66.66%) patients were developed ADRs to antihypertensive drugs. 8 (85.72%) were male and 2 (14.28%) were female. Calcium channel blockers were the commonest therapeutic class of antihypertensive drugs associated with ADRS (n = 50, 64.10%). According to WHO causality assessment scale most of the ADRs of Amlodipine were "probable" 8(57.14%) followed by "possible" 2 (14.28%), certain 4 (28.57%)). According to Hartwig and Siegel scale of severity assessment, the most of the adrs were mild 10(71.42%) and moderate 4 (28.57%). According to Schumock and Thornton scale of preventability assessment all ADR are definitely preventable. Conclusions: The results of this study concluded that antihypertensive drugs able to induce the development of adverse drug reactions, which were significant cause of increase burden on health care system and decrease the quality of life, the health care professionals should take care about the rational use of antihypertensive agents. Thus, to minimize the incidence of adverse drug reaction and to increase the quality of life.
背景:每种药物都有可能引起药物不良反应(ADR)。不良反应是药物治疗中的一个主要问题。本研究旨在评估2022年4月至2022年6月期间原发性高血压患者氨氯地平(降压药)不良反应的发生率、因果关系、严重程度和可预防性。方法:本前瞻性观察研究在普通内科门诊对15例患者进行。结果:15例患者中有10例(66.66%)出现抗高血压药物不良反应。男性8例(85.72%)，女性2例(14.28%)。钙通道阻滞剂是与adr相关的最常见的降压药物(n = 50, 64.10%)。根据WHO因果评价量表，氨氯地平不良反应以“可能”8级(57.14%)居多，其次为“可能”2级(14.28%)，“一定”4级(28.57%)。根据Hartwig and Siegel严重程度评定量表，adr以轻度10分(71.42%)和中度4分(28.57%)居多。根据Schumock和Thornton可预防性评估量表，所有不良反应都是绝对可预防的。结论:降压药可诱发药物不良反应的发生，是增加卫生保健系统负担、降低生活质量的重要原因，医护人员应注意合理使用降压药。从而最大限度地减少药物不良反应的发生，提高患者的生活质量。
{"title":"To Assess Causality, Severity and Preventability of Adverse drug reactions of Amlodipine in the treatment of hypertension","authors":"Akanksha K. Mane, V. Chaware","doi":"10.52711/0974-4150.2023.00007","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00007","url":null,"abstract":"Background: Every drug has the potentiality to cause an adverse drug reaction (ADR). ADRs are a major problem in drug therapy. The aim of this study was to assess the incidence and causality, severity and Preventability of ADRs Amlodipine (antihypertensive agents) used for the essential hypertensive patients during the time period of April 2022 to Jun 2022. Methods: This prospective-observational study was carried out in general medicine outpatient department in 15 Patients. Results: Out of 15 patients, 10 (66.66%) patients were developed ADRs to antihypertensive drugs. 8 (85.72%) were male and 2 (14.28%) were female. Calcium channel blockers were the commonest therapeutic class of antihypertensive drugs associated with ADRS (n = 50, 64.10%). According to WHO causality assessment scale most of the ADRs of Amlodipine were \"probable\" 8(57.14%) followed by \"possible\" 2 (14.28%), certain 4 (28.57%)). According to Hartwig and Siegel scale of severity assessment, the most of the adrs were mild 10(71.42%) and moderate 4 (28.57%). According to Schumock and Thornton scale of preventability assessment all ADR are definitely preventable. \u0000Conclusions: The results of this study concluded that antihypertensive drugs able to induce the development of adverse drug reactions, which were significant cause of increase burden on health care system and decrease the quality of life, the health care professionals should take care about the rational use of antihypertensive agents. Thus, to minimize the incidence of adverse drug reaction and to increase the quality of life.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79701875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-24DOI: 10.52711/0974-4150.2023.00011
Khadidja Amirat, N. Ziani, Souhaila Meneceur, Fatiha Mebarki, Abderrhmane Bouafia
A structure / lethal dose 50 (pCIC50) relationship was researched for a set of phenols while favoring a hybrid genetic algorithm (GA) / multiple linear regression (MLR) approaches to the structural parameters being computed with (E-calc) which calcula the Kier–Hall Electrotopological state indices (E- state) and Hyperchem software. Among the more than 100 simple models with two explanatory variables acquired, we chose the model with the best values of the prediction parameter (Q2) and the coefficient of determination (R2). The reliability of the proposed model has also been illustrated using various techniques of evaluation: leave-many out, cross-validation, randomization test, and validation by the test set. pCIC50 = - 0.0835 ± (0.07006) +0.112 ± (0.007408 (logkow)2 - 0.116 ± (0.01797) s-CH3 ntot = 81 ; S= 0.3296 log unit ; Q2(%) = 74.26 ; R2 (%)= 79.24 ; F= 118.3193; P=0,000.
{"title":"Modeling of Aquatic Toxicity of a Set of Phenols in Silico","authors":"Khadidja Amirat, N. Ziani, Souhaila Meneceur, Fatiha Mebarki, Abderrhmane Bouafia","doi":"10.52711/0974-4150.2023.00011","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00011","url":null,"abstract":"A structure / lethal dose 50 (pCIC50) relationship was researched for a set of phenols while favoring a hybrid genetic algorithm (GA) / multiple linear regression (MLR) approaches to the structural parameters being computed with (E-calc) which calcula the Kier–Hall Electrotopological state indices (E- state) and Hyperchem software. Among the more than 100 simple models with two explanatory variables acquired, we chose the model with the best values of the prediction parameter (Q2) and the coefficient of determination (R2). The reliability of the proposed model has also been illustrated using various techniques of evaluation: leave-many out, cross-validation, randomization test, and validation by the test set.\u0000pCIC50 = - 0.0835 ± (0.07006) +0.112 ± (0.007408 (logkow)2 - 0.116 ± (0.01797) s-CH3\u0000ntot = 81 ; S= 0.3296 log unit ; Q2(%) = 74.26 ; R2 (%)= 79.24 ; F= 118.3193; P=0,000.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91302286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-24DOI: 10.52711/0974-4150.2023.00004
Mimouna Hani, C. Boubekri, T. Lanez
In this study, two solvents with different polarity were used in the extraction of the dried powdered roots of the plant Juncus rigidus; ethanol, acetone, during two different growth stages : ripening period (November) and flowering period (April). Total phenolics, total flavonoids, and total flavanols contents were evaluated using the colorimetric assays. The obtained results were very significant and showed that polarity of solvents and growth stage affects the composition of the plant. The highest content in total phenolic (87,249 ± 0.005 mg GAE/g), total flavonoid (28,109 ± 0.041 mg QE/g) and total flavonol (33,195 ± 0,013 mg GAE/g) contents was obtained in acetone extract during flowering period witch decrease during ripening period. The best result for the evaluation of the antioxidant activity indicated that highest value in DPPH free radical scavenging activity (0,014 ± 0,0003 mg/mL-1), phosphomolybdenum assay (425,168 ± 0,006 mL/mg), ferric reducing antioxidant power (1217,914 ± 0,022 mgFeSO4/g) and cyclic voltammetry (47,07 ± 0,04 mg/g) was unregistered during ripening stage using acetone solvent.
{"title":"Variation in Phenolic Composition, Antioxidant Activity and Cyclic Voltammetry Study of Juncus rigidus Desf. (Juncaceae) Root Extracts according Flowering and Ripening Period","authors":"Mimouna Hani, C. Boubekri, T. Lanez","doi":"10.52711/0974-4150.2023.00004","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00004","url":null,"abstract":"In this study, two solvents with different polarity were used in the extraction of the dried powdered roots of the plant Juncus rigidus; ethanol, acetone, during two different growth stages : ripening period (November) and flowering period (April). Total phenolics, total flavonoids, and total flavanols contents were evaluated using the colorimetric assays. The obtained results were very significant and showed that polarity of solvents and growth stage affects the composition of the plant. The highest content in total phenolic (87,249 ± 0.005 mg GAE/g), total flavonoid (28,109 ± 0.041 mg QE/g) and total flavonol (33,195 ± 0,013 mg GAE/g) contents was obtained in acetone extract during flowering period witch decrease during ripening period. The best result for the evaluation of the antioxidant activity indicated that highest value in DPPH free radical scavenging activity (0,014 ± 0,0003 mg/mL-1), phosphomolybdenum assay (425,168 ± 0,006 mL/mg), ferric reducing antioxidant power (1217,914 ± 0,022 mgFeSO4/g) and cyclic voltammetry (47,07 ± 0,04 mg/g) was unregistered during ripening stage using acetone solvent.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83344789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-24DOI: 10.52711/0974-4150.2023.00002
Arjun Singh, Rupendra Kumar
In recent years, there has been a significant increase in interest in plant-derived compounds and their function in sustaining health and avoiding illness. These substances are referred to as phytochemicals or nutraceuticals, which are essentially defined as a food or component of a food that delivers medicinal or health advantages. Natural bioactive phytochemicals, particularly those found in fruits and vegetables, are significant food components because they may provide health advantages associated to the prevention of a variety of diseases, including obesity. Health problems are now a major public health concern all over the world due to the clinical complications it causes, which have a significant impact on life expectancy. Cancer and cardiovascular disease, in particular, are the leading causes of death associated with obesity. However, convincing proof for identification is lacking.
{"title":"An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols","authors":"Arjun Singh, Rupendra Kumar","doi":"10.52711/0974-4150.2023.00002","DOIUrl":"https://doi.org/10.52711/0974-4150.2023.00002","url":null,"abstract":"In recent years, there has been a significant increase in interest in plant-derived compounds and their function in sustaining health and avoiding illness. These substances are referred to as phytochemicals or nutraceuticals, which are essentially defined as a food or component of a food that delivers medicinal or health advantages. Natural bioactive phytochemicals, particularly those found in fruits and vegetables, are significant food components because they may provide health advantages associated to the prevention of a variety of diseases, including obesity. Health problems are now a major public health concern all over the world due to the clinical complications it causes, which have a significant impact on life expectancy. Cancer and cardiovascular disease, in particular, are the leading causes of death associated with obesity. However, convincing proof for identification is lacking.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85796891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22271/reschem.2023.v4.i1a.81
PK Vishwakarma, RC Maurya
This research article reports the experimental and theoretical model of the synthesised ligand (E)-4- (((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene) amino) benzenesulfonamide (HL) and their complex cis-[MoO 2 (L) 2 )] {1}. The physicochemical, spectral, and theoretical results proposed the molecular formula of the complex as cis-[MoO 2 (L) 2 ] (where L = monobasic bidentate ligand of 4 - formyl-3-methyl-1-phenyl-2-pyrazoline-5-one with sulfanilamide . The colored solid mass was grown, washed with ethanol, and dried in air. The complex is soluble in inorganic solvent like DMF and DMSO and organic solvents like methanol, ethanol, and acetonitrile. The computed results like geometry, molecular orbital analysis and NLO properties done via DFT approach. The computed geometrical results have determined the molecular structure of the compound. It has been shaped that the ligand coordinates via azomethine nitrogen and enolic oxygen of Schiff base moiety, by a 1:2 metal-ligand ratio. Furthermore, the title compounds were also showing Insilco bioactivity score and drug-likeness by molinspiration software and ADME properties resulted pharmacological action of the compounds.
{"title":"Synthesis, characterization and DFT studies of Schiff base (E)-4-(((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene) amino)-benzenesulfonamide and its MoO2 (II) complex","authors":"PK Vishwakarma, RC Maurya","doi":"10.22271/reschem.2023.v4.i1a.81","DOIUrl":"https://doi.org/10.22271/reschem.2023.v4.i1a.81","url":null,"abstract":"This research article reports the experimental and theoretical model of the synthesised ligand (E)-4- (((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene) amino) benzenesulfonamide (HL) and their complex cis-[MoO 2 (L) 2 )] {1}. The physicochemical, spectral, and theoretical results proposed the molecular formula of the complex as cis-[MoO 2 (L) 2 ] (where L = monobasic bidentate ligand of 4 - formyl-3-methyl-1-phenyl-2-pyrazoline-5-one with sulfanilamide . The colored solid mass was grown, washed with ethanol, and dried in air. The complex is soluble in inorganic solvent like DMF and DMSO and organic solvents like methanol, ethanol, and acetonitrile. The computed results like geometry, molecular orbital analysis and NLO properties done via DFT approach. The computed geometrical results have determined the molecular structure of the compound. It has been shaped that the ligand coordinates via azomethine nitrogen and enolic oxygen of Schiff base moiety, by a 1:2 metal-ligand ratio. Furthermore, the title compounds were also showing Insilco bioactivity score and drug-likeness by molinspiration software and ADME properties resulted pharmacological action of the compounds.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72756225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22271/reschem.2023.v4.i1a.82
P. Vishwakarma, R. Maurya
Both experimental and theoretical chemistry is the preeminent discipline of the chemical sciences. In the striking fascination of this work, we have presented the synthesis and characterization of 4-formyl-3-methyl-1-phenyl-2-pyrazolon-5-one with the isonicotinic acid hydrazide-derived Schiff base H 2 L and its cis-dioxidomolybdenum(II) complexes [MoO 2 (L)(CH 3 OH)] 1 and [MoO 2 (L)(Hbimd)] 2 (Hbimd: benzimidazole). Characterization was based on spectral methods, which showed that the complexes exhibit neutral monomeric distorted octahedral geometry. The DFT approach was used for the theoretical study of the compounds. Finally, the compounds were evaluated using the Insilco Bioactivity Score and Drug-Likeness using the online server and ADME properties that led to the pharmaceutical chemistry of the compounds. The biological results, both experimental and insilco, are promising for their future use as medicinally relevant compounds
{"title":"Experimental and theoretical studies of MoO2(II) complexes based on pyrazoline and hydrazone derived Schiff base","authors":"P. Vishwakarma, R. Maurya","doi":"10.22271/reschem.2023.v4.i1a.82","DOIUrl":"https://doi.org/10.22271/reschem.2023.v4.i1a.82","url":null,"abstract":"Both experimental and theoretical chemistry is the preeminent discipline of the chemical sciences. In the striking fascination of this work, we have presented the synthesis and characterization of 4-formyl-3-methyl-1-phenyl-2-pyrazolon-5-one with the isonicotinic acid hydrazide-derived Schiff base H 2 L and its cis-dioxidomolybdenum(II) complexes [MoO 2 (L)(CH 3 OH)] 1 and [MoO 2 (L)(Hbimd)] 2 (Hbimd: benzimidazole). Characterization was based on spectral methods, which showed that the complexes exhibit neutral monomeric distorted octahedral geometry. The DFT approach was used for the theoretical study of the compounds. Finally, the compounds were evaluated using the Insilco Bioactivity Score and Drug-Likeness using the online server and ADME properties that led to the pharmaceutical chemistry of the compounds. The biological results, both experimental and insilco, are promising for their future use as medicinally relevant compounds","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79021841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22271/reschem.2023.v4.i1a.77
D. Aziz, Ruqaya Ali Mahdi, Mustafa Ammar Mahdi, Zainab Muwafaq Talib, Ahmed Hussein Mohsin, Esraa Zeman Dayea
Chronic renal failure is a condition in which the kidneys gradually lose their ability to function because of the gradual loss of their parenchyma. This study aimed to detect some hematological and biochemical parameters in patients with chronic kidney disease (CKD) attending a hemodialysis center. A cross-sectional study included a review of (89) cases of chronic kidney disease at Al-Hakeem Hospital's dialysis center in Najaf from September 7th to October 16th, 2021. The collected data were analyzed using Office Excel and SPSS-23. Variables were analyzed by frequencies, proportions, and percentages. The current study discovered that males had longer sequences than females, and that patients in rural areas had longer sequences than those in urban areas. In the current study, blood Sug, B. Urea, S. Crea, K, Na, Cl, Ca+2, Alb, and Tpro levels did not differ significantly between males and females with renal failure, whereas HB and TCA levels did. At last, we recommend people conduct an early medical examination for kidney disease, especially those who suffer from symptoms such as low urine output, swelling of the legs, fatigue, tachycardia, and others, to obtain early treatment.
{"title":"Assessment of some hematological and biochemical parameters in patients with renal failure in Al-najaf province","authors":"D. Aziz, Ruqaya Ali Mahdi, Mustafa Ammar Mahdi, Zainab Muwafaq Talib, Ahmed Hussein Mohsin, Esraa Zeman Dayea","doi":"10.22271/reschem.2023.v4.i1a.77","DOIUrl":"https://doi.org/10.22271/reschem.2023.v4.i1a.77","url":null,"abstract":"Chronic renal failure is a condition in which the kidneys gradually lose their ability to function because of the gradual loss of their parenchyma. This study aimed to detect some hematological and biochemical parameters in patients with chronic kidney disease (CKD) attending a hemodialysis center. A cross-sectional study included a review of (89) cases of chronic kidney disease at Al-Hakeem Hospital's dialysis center in Najaf from September 7th to October 16th, 2021. The collected data were analyzed using Office Excel and SPSS-23. Variables were analyzed by frequencies, proportions, and percentages. The current study discovered that males had longer sequences than females, and that patients in rural areas had longer sequences than those in urban areas. In the current study, blood Sug, B. Urea, S. Crea, K, Na, Cl, Ca+2, Alb, and Tpro levels did not differ significantly between males and females with renal failure, whereas HB and TCA levels did. At last, we recommend people conduct an early medical examination for kidney disease, especially those who suffer from symptoms such as low urine output, swelling of the legs, fatigue, tachycardia, and others, to obtain early treatment.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75304867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22271/reschem.2023.v4.i1a.69
M. Soni, D. Gautam, Dr. Pawan Raj Shakya
The current study described a thorough analysis of the adsorption characteristics of a hydrogel that was chemically connected and built on agar and carboxymethyl cellulose (CMC). With regard to swelling %, the Agar-Agar/ECH/CMC hydrogel was created under ideal conditions. In order to achieve the highest percentage of swelling, different response parameters were changed. The structure and morphology of the hydrogels were characterized by FT-IR spectroscope, thermogravimetric analysis and scanning electron microscope. The results revealed that the CMC contributed to the enhanced size of pore, whereas Agar-Agar as a strong backbone in the hydrogel to support it for keeping its appearance. Their equilibrium swelling ratio in distilled water and different physiological fluids were evaluated, indicating the maximum swelling ratio in water reached an exciting level of 1000 as the hydrogels still keeping a steady appearance. Moreover, the hydrogels exhibited smart swelling and shrinking in NaCl or CaCl2 aqueous solution, as well as the release behavior of bovine serum albumin (BSA) that could be controlled by changing CMC content. The Agar-Agar -based hydrogels are promising for the applications
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