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Maturation of the Sympatho‐Adrenal System and Clinical Values of the Determination of Urinary Catecholamine Excretion 交感肾上腺系统的成熟和尿儿茶酚胺排泄量测定的临床价值
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1981.TB00529.X
T. Nakai
Sympatho-adrenal system function was assessed in various age groups of normal subjects and in infants with some abnormal conditions, by assays of daily urinary catecholamine excretion. The urinary catecholamine excretion was prone to increase postnatally with time. The group of children aged 1 to 5 years exhibited a significantly greater urinary catecholamine excretion than the group of newborn infants. No significant difference concerning urinary catecholamine excretion was observed among three age groups, 1–5, 6–10 and 10–20 years of age. This finding is related to rapid growth and maturation of the sympatho-adrenal system in early life with increased catecholamine excretion. Moreover, the urinary catecholamine excretion was remarkably increased at symptomatic exacerbation and declined to a normal level with alleviation of symptoms in a case of respiratory distress syndrome. The present communication is the first to demonstrate the usefulness of urinary catecholamine determination in newborn infants.
通过每日尿儿茶酚胺排泄量的测定,评估了不同年龄组正常受试者和有一些异常情况的婴儿的交感-肾上腺系统功能。尿儿茶酚胺排泄量随出生时间增加而增加。1 ~ 5岁儿童尿儿茶酚胺排泄量明显高于新生儿。尿儿茶酚胺排泄量在1 ~ 5岁、6 ~ 10岁和10 ~ 20岁三个年龄组间无显著差异。这一发现与早期伴随儿茶酚胺分泌增加的交感-肾上腺系统的快速生长和成熟有关。此外,尿儿茶酚胺排泄量在症状加重时显著增加,在呼吸窘迫综合征的病例中,随着症状减轻而下降到正常水平。目前的通讯是第一个证明尿儿茶酚胺测定在新生儿有用。
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引用次数: 0
Pregnancy after chemotherapy for trophoblastic diseases and psychosomatic development in the progeny. 滋养层疾病化疗后妊娠与子代心身发育。
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1993.TB00401.X
I. Suzuki, S. Goto, A. Yamada, Y. Tomoda
We treated 542 patients with trophoblastic diseases from 1965 through 1988, and succeeded in preserving fertility in 269 of them (240 cases of invasive mole and 29 cases of choriocarcinoma). Of the 269 patients, 198 (79.5%) conceived after completing treatment. A total of 396 pregnancies in these women resulted in 295 term live births (74.5%), 51 spontaneous abortions (12.9%), and 4 recurrences of moles (1.0%). Four cases (1.32%) of malformations were discovered. The growth conditions of 101 children born in 1976 or later were followed up until the age of 18 months. Their heights or weights did not differ significantly from those of children measured in national infantile-growth surveys. The psychoneurological development of 54 children up to the age of 7 years who were studied by using infantile mental-development questionnaires showed no marked mental retardation. Our results provide strong evidence of the safety of chemotherapy for the treatment of trophoblastic diseases.
从1965年到1988年,我们治疗了542例滋养细胞疾病患者,其中269例(240例浸润性痣和29例绒毛膜癌)成功地保留了生育能力。269例患者中,198例(79.5%)在完成治疗后怀孕。这些妇女共396次怀孕,其中295例足月活产(74.5%),51例自然流产(12.9%),4例痣复发(1.0%)。发现畸形4例(1.32%)。对101名1976年或以后出生的儿童的生长情况进行了随访,直到他们18个月大。他们的身高或体重与全国婴儿成长调查中测量的儿童没有显著差异。采用儿童心理发展问卷对54例7岁以下儿童的心理神经发育进行了调查,结果显示,儿童的智力发育没有明显的迟滞。我们的结果为化疗治疗滋养细胞疾病的安全性提供了强有力的证据。
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引用次数: 5
Immunological Study on the Mechanism of Lymph Node Metstasis 淋巴结转移机制的免疫学研究
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1981.TB00515.X
N. Umesaki, Touman Lee, H. Nakamori, H. Sako, Jyunko Nakade, T. Sugawa
Existence of lymph node metastasis is a risk factor in the prognosis of patients with cervical cancer. But the mechanism of lymph node metastasis and its control factor are not clear. This study was implemented to elucidate this mechanism based on animal experiments. Mouse hepatoma cell (MH 134) was used as the material for Tumor Extract (TE), which was prepared by ultrasonication. After pretreatment with TE at various concentrations and various durations on the left footpads of mice, inoculation of tumor cells was performed at the same site. Regional lymph nodes from this site were obtained after various durations and the rate of lymph node metastasis was histologically observed. Immunocapacity of lymph node cells due to various mitogens were also measured after pretreatment with TE. As a result, pretreatment with TE effected a decrease in immunocapacity of the lymph node cells, especially the T-cells. On the other hand, pretreatment with TE also brought about an increase in the rate of lymph node metastasis. In conclusion it can be said that the soluble substance derived from the cancer mass decreased the immunocapacity of regional lymph nodes. Therefore, lymph node metastasis was considered to have been effected.
存在淋巴结转移是影响宫颈癌患者预后的危险因素。但淋巴结转移的发生机制及控制因素尚不清楚。本研究旨在通过动物实验来阐明这一机制。以小鼠肝癌细胞(MH 134)为原料,采用超声法制备肿瘤提取物(TE)。用不同浓度、不同时间的TE预处理小鼠左脚垫后,在同一部位接种肿瘤细胞。在不同的时间后从该部位获得区域淋巴结,组织学观察淋巴结转移率。同时测定TE预处理后淋巴结细胞对各种丝裂原的免疫能力。结果,TE预处理导致淋巴结细胞,尤其是t细胞的免疫能力下降。另一方面,TE预处理也带来了淋巴结转移率的增加。综上所述,来源于癌块的可溶性物质降低了区域淋巴结的免疫能力。因此,淋巴结转移被认为已经受到影响。
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引用次数: 0
Perinatal Statistics of Registry Hospitals of Japan in 1974 to 1978 by The Committee on Perinatal Statistics of the Japan Society of Obstetrics and Gynecology 日本妇产科学会围产期统计委员会1974年至1978年日本登记医院围产期统计
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1981.TB00512.X
C. Sakamoto, Co‐chairman K. Maeda
Annual reports of perinatal statistics in Japan from about 200 registry hospitals are summarized. A gradual decrease in the perinatal mortality rate has been observed from 16.04 in 1974 to 13.50 in 1978. Among the initially registered 129 hospitals, a similar decrease in perinatal mortality has been observed. Among the 18 main clinical causes of death, the percentages of placenta previa and neonatal respiratory distress exhibited a decrease during the last 5 years. Among the cases of perinatal death, in member hospitals of the Committee on Perinatal Statistics, three criteria were used to determine the perinatal stage for purposes of comparison, namely: 1) a gestational age of 28 or more weeks, or alternatively, birthweights of 2) 500 to 999.9 g or 3) 1000 g or more. Perinatal mortality was lowest in the group weighing 1000 g or more (9.87), slightly higher in the group aged 28 weeks or more (10.94) and highest in 500 to 999.9 g group (14.40). Individual case reports of perinatal death in member hospitals of the Committee are analyzed, and an ICD-based investigation elucidated the characteristic patterns of perinatal death.
总结了日本约200家登记医院的围产期统计年度报告。围产期死亡率逐渐下降,从1974年的16.04下降到1978年的13.50。在最初登记的129家医院中,围产期死亡率也出现了类似的下降。在18种主要临床死亡原因中,前置胎盘和新生儿呼吸窘迫的百分比在过去5年中呈下降趋势。在围产期统计委员会成员医院的围产期死亡病例中,为了进行比较,采用了三个标准来确定围产期阶段,即:1)胎龄28周或28周以上,或者出生体重为500至999.9克或3)1000克或更多。围产期死亡率以体重1000 g及以上组最低(9.87),28周及以上组略高(10.94),500 ~ 999.9 g组最高(14.40)。分析了委员会成员医院的围产期死亡个案报告,并基于icd的调查阐明了围产期死亡的特征模式。
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引用次数: 0
Clinical Studies on the Termination of Pregnancy by the Vaginal Administration of 16, 16‐Dimethyl—Trans—Δ2‐PGE1 methyl Ester (ONO 802) 阴道给药16,16‐二甲基反式-Δ2‐PGE1甲酯(ONO 802)终止妊娠的临床研究
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1981.TB00536.X
Chang Chai‐fen, Zhang Zhuo-min, Liu Zi-xin, Gou Yong‐yi
A prostagladin analogue, 16-16-Dimethyl-trans-Δ2-PGE1 methyl ester from ONO Pharmaceutical Co., Ltd. was studied by the vaginal administration of suppositories for termination of early and 2nd trimesters of pregnancy. Clinical efficacy and side effects were observed and evaluated.
研究了ONO制药有限公司生产的前列腺素类似物16-16-二甲基反式-Δ2-PGE1甲酯,通过阴道给药栓剂终止妊娠早期和中期。观察并评价临床疗效及不良反应。
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引用次数: 0
The Incidence of Endometriosis in Japanese Women 日本女性子宫内膜异位症的发病率
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1981.TB00520.X
N. Furuhashi, F. Nagaike, N. Furuhashi, Katsuyuki Takahashi, Masakuni Suzuki
We evaluated the frequency of endometriosis among the patients who underwent laparotomy and studied retrospectively the frequency of endometriosis in Japanese women. The frequency of operation for endometriosis has been about 0.6% of all the new outpatients and 10.8% of patients with laparotomy. We found a higher frequency of endometriosis in the most recent period (1977–1979). The mean age of endometriosis patients was 40.74 + 0.65 (mean + SE) years old. Our results indicated that the frequency of endometriosis in Japanese women has increased during the last two decades.
我们评估了剖腹手术患者子宫内膜异位症的发生频率,并对日本女性子宫内膜异位症的发生频率进行了回顾性研究。子宫内膜异位症的手术频率约占所有新门诊患者的0.6%,占剖腹手术患者的10.8%。我们发现最近一段时期(1977-1979)子宫内膜异位症的发病率较高。子宫内膜异位症患者的平均年龄为40.74 + 0.65(平均+ SE)岁。我们的结果表明,子宫内膜异位症的频率在日本妇女在过去的二十年有所增加。
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引用次数: 0
Masahiko Mizuno MD, MedScD, FRACOG, FAOFOG Professor Emeritus of Gynaecology and Obstetrics, University of Tokyo Masahiko Mizuno MD,医学博士,FRACOG, FAOFOG妇产科名誉教授,东京大学
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1993.TB00356.X
P. Elliott
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引用次数: 0
Diagnosis and Prognosis of Fetal Malformation by Ultrasonic Tomography 胎儿畸形的超声断层诊断与预后
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1981.TB00527.X
H. Nakano, T. Koyanagi, S. Kubota, C. Sakamoto, T. Shin, I. Taki
The incidence of fetal malformation was reviewed and an assessment made of the diagnostics of ultrasound. The prognosis of the related cases, as related to the clinical application of ultrasound was discussed. Forty-seven of 56 malformed fetuses were correctly diagnosed antenatally (84%). Diagnostic accuracy in the case of real-time B scan was 91%, while accuracy in the case of contact compound scan was 73%. The disorders most readily identifiable were those related to the image of cystic patterns and/or deformed body contour. Among the 47 with positive findings, an actual plan of treatment was prepared for 9. Of these 9, 6 could actually be treated and the lives of 3 were saved. Deaths were attributed to diagnostic inadequacy, eventual complications and under-development of organs associated with the malformations.
本文综述了胎儿畸形的发生率,并对超声诊断进行了评价。并对相关病例的预后与超声的临床应用进行了讨论。56例畸形胎儿中47例(84%)产前诊断正确。实时B扫描的诊断准确率为91%,接触复合扫描的诊断准确率为73%。最容易识别的疾病是那些与囊性模式和/或变形的身体轮廓图像有关的疾病。在47例阳性结果中,有9例制定了实际的治疗计划。在这9人中,6人可以得到治疗,3人的生命得到了挽救。死亡的原因是诊断不充分、最终的并发症和与畸形有关的器官发育不全。
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引用次数: 0
Receptors and Mechanism Action of Synthetic Progestogens 合成孕激素的受体及其作用机制
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1981.TB00511.X
H. Okada
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引用次数: 0
Colposcopic index of HPV and CIN patients. HPV和CIN患者的阴道镜指数。
Pub Date : 2010-05-24 DOI: 10.1111/J.1447-0756.1993.TB00362.X
M. Roy
There were 115 patients who had atypical transformation zone on colposcopic examination which attended this study. This prospective study was held in the author's private colposcopy clinic from July 1, 1989 until December 31, 1991. The colposcopic index was used to describe the colposcopic sign of those lesions and histopathology results were adopted as the gold standard of diagnosis. This colposcopic index had an accuration rate of 95.7% compared to histopathology diagnosis.
本研究共收集了115例阴道镜检查中出现不典型转化带的患者。这项前瞻性研究于1989年7月1日至1991年12月31日在作者的私人阴道镜诊所进行。阴道镜指数用于描述这些病变的阴道镜征象,组织病理学结果作为诊断的金标准。与组织病理学诊断相比,该阴道镜指数的准确率为95.7%。
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引用次数: 0
期刊
Asia-Oceania journal of obstetrics and gynaecology
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