Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00526.X
Toshi Kato, M. Yakushiji
The Ovarian Committee of the Japan Society of Obstetrics and Gynecology (JOC) was established in 1961. Since then, using its own classification, it has registered different types of ovarian neoplasms. This paper describes the JOC classification as well as the management of ovarian malignancies based on the reported results in the literature of Europe, the USA and of our clinic.
{"title":"MANAGEMENT OF MALIGNANT OVARIAN TUMORS","authors":"Toshi Kato, M. Yakushiji","doi":"10.1111/J.1447-0756.1981.TB00526.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00526.X","url":null,"abstract":"The Ovarian Committee of the Japan Society of Obstetrics and Gynecology (JOC) was established in 1961. Since then, using its own classification, it has registered different types of ovarian neoplasms. \u0000 \u0000 \u0000 \u0000This paper describes the JOC classification as well as the management of ovarian malignancies based on the reported results in the literature of Europe, the USA and of our clinic.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"20 1","pages":"211-221"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76761214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00538.X
F. U. Edozien
Galactorrhoea was found to occur in 24% of infertile female patients presenting at Military Hospital, Yaba. 46 out of 57 patients had no other cause to explain their infertility. II, however, had pelvic and other endocrine associations. The endocrine factors found were examined. Hyperprolactinaemia is suggested as a probable mechanism of amenorrhoea following oral contraception.
{"title":"Galactorrhea Associated with Infertility in a Military Hospital","authors":"F. U. Edozien","doi":"10.1111/J.1447-0756.1981.TB00538.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00538.X","url":null,"abstract":"Galactorrhoea was found to occur in 24% of infertile female patients presenting at Military Hospital, Yaba. 46 out of 57 patients had no other cause to explain their infertility. II, however, had pelvic and other endocrine associations. The endocrine factors found were examined. Hyperprolactinaemia is suggested as a probable mechanism of amenorrhoea following oral contraception.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"70 1","pages":"325-330"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76448833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00523.X
K. Takizawa, T. Kawana, K. Shiromizu, S. Sakamoto
Both serum C-reactive protein (CRP) and alpha 1-acid glycoprotein (AAG) were measured in 22 patients with benign ovarian tumors, 58 patients with ovarian cancer and 31 normal controls, using a single radial immunodiffusion technique. In most normal women as well as patients with benign ovarian tumors, serum CRP was lower than 2 μg/ml and AAG lower than 80 mg/dl. In 15 of 25 untreated patients with ovarian cancer and in 14 of 16 patients with recurrence, both serum CRP and AAG were above 2 μg/ml and 80 mg/dl respectively. Serum CRP and AAG levels were measured sequentially in 9 patients with ovarian cancer after initial treatment. Serum CRP and AAG levels in 5 patients without recurrence had returned to and remained at normal levels after successful treatment. In contrast, 4 patients with recurrence exhibited elevations in serum CRP and AAG levels above the normal range. It is worth notions that these proteins increased before clinical evidence of recurrence. These studies suggest that serial measurement of CRP and AAG may be of great use in the surveillance of patients with ovarian cancer following initial treatment.
{"title":"Microquantitative Estimation of Serum C‐Reactive Protein and Alpha 1‐Acid Glycoprotein in Patients with Ovarian Cancer","authors":"K. Takizawa, T. Kawana, K. Shiromizu, S. Sakamoto","doi":"10.1111/J.1447-0756.1981.TB00523.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00523.X","url":null,"abstract":"Both serum C-reactive protein (CRP) and alpha 1-acid glycoprotein (AAG) were measured in 22 patients with benign ovarian tumors, 58 patients with ovarian cancer and 31 normal controls, using a single radial immunodiffusion technique. In most normal women as well as patients with benign ovarian tumors, serum CRP was lower than 2 μg/ml and AAG lower than 80 mg/dl. In 15 of 25 untreated patients with ovarian cancer and in 14 of 16 patients with recurrence, both serum CRP and AAG were above 2 μg/ml and 80 mg/dl respectively. Serum CRP and AAG levels were measured sequentially in 9 patients with ovarian cancer after initial treatment. Serum CRP and AAG levels in 5 patients without recurrence had returned to and remained at normal levels after successful treatment. In contrast, 4 patients with recurrence exhibited elevations in serum CRP and AAG levels above the normal range. It is worth notions that these proteins increased before clinical evidence of recurrence. These studies suggest that serial measurement of CRP and AAG may be of great use in the surveillance of patients with ovarian cancer following initial treatment.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"6 1","pages":"163-173"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76899159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00541.X
N. Furuhashi, V. Fang
Estrogen production by feminizing adrenal neoplastic cells (Fang-8 cells) in culture was stimulated by human prolactin (hPRL). The existence of hPRL receptor in the cells was demonstrated. The stimulatory effect of hPRL was abolished by dopamine and CB-154 (2-bromo-α-ergocriptine), since CB-154, at 60 μg/dish, inhibited cell growth and estrogen production in the absence of hPRL and since dopamine may involve different mechanisms of action. The action of CB-154 was blocked by propranolol, not by phenoxybenzamine or pimozide. Since we could not demonstrate adrenergic or dopaminergic receptor in Fang-8 cells, the interaction between CB-154 and propranolol may not be explained by a pharmacological beta-adrenergic mechanism.
{"title":"Human Prolactin Receptor and Dopamine Actions in Feminizing Adrenal Neoplastic Cells","authors":"N. Furuhashi, V. Fang","doi":"10.1111/J.1447-0756.1981.TB00541.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00541.X","url":null,"abstract":"Estrogen production by feminizing adrenal neoplastic cells (Fang-8 cells) in culture was stimulated by human prolactin (hPRL). The existence of hPRL receptor in the cells was demonstrated. The stimulatory effect of hPRL was abolished by dopamine and CB-154 (2-bromo-α-ergocriptine), since CB-154, at 60 μg/dish, inhibited cell growth and estrogen production in the absence of hPRL and since dopamine may involve different mechanisms of action. The action of CB-154 was blocked by propranolol, not by phenoxybenzamine or pimozide. Since we could not demonstrate adrenergic or dopaminergic receptor in Fang-8 cells, the interaction between CB-154 and propranolol may not be explained by a pharmacological beta-adrenergic mechanism.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"51 1","pages":"349-353"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78287415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00521.X
T. Sugawa, M. Hashimoto, Masakuni Suzuki, S. Kuríhara, T. Kasamatsu, Y. Takamizawa, S. Takeuchi, T. Chihara, S. Tojo, K. Sekiba, I. Taki, Toshi Kato, M. Maeyama
In a survey of patients with vulvar cancer registered during the period from 1968 through 1970, a total of 319 cases were registered at 82 medical institutions in Japan, and the data from these cases were statistically analyzed to find the current status of onset and treatment of this malignancy in Japan. The results of vulvar cancer treatment in terms of 3-year and 5-year survival rates in this country proved similar to those recently attained in other countries. It was learned that the use of bleomycin for treatment of this malignancy was widespread, and analysis of its therapeutic effects revealed that both the primary effects and long-term effects were rather satisfactory.
{"title":"Clinical Aspects and Treatment of Vulvar Cancer in Japan","authors":"T. Sugawa, M. Hashimoto, Masakuni Suzuki, S. Kuríhara, T. Kasamatsu, Y. Takamizawa, S. Takeuchi, T. Chihara, S. Tojo, K. Sekiba, I. Taki, Toshi Kato, M. Maeyama","doi":"10.1111/J.1447-0756.1981.TB00521.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00521.X","url":null,"abstract":"In a survey of patients with vulvar cancer registered during the period from 1968 through 1970, a total of 319 cases were registered at 82 medical institutions in Japan, and the data from these cases were statistically analyzed to find the current status of onset and treatment of this malignancy in Japan. \u0000 \u0000 \u0000 \u0000The results of vulvar cancer treatment in terms of 3-year and 5-year survival rates in this country proved similar to those recently attained in other countries. It was learned that the use of bleomycin for treatment of this malignancy was widespread, and analysis of its therapeutic effects revealed that both the primary effects and long-term effects were rather satisfactory.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"152 1","pages":"141-154"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86227017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00540.X
H. Honjo, K. Omori, Takao Yamamoto, Kazuo Otsubo, C. Sakai, K. Tsukamoto, J. Yasuda, M. Fujii, J. Yamaki, H. Okada, M. Numazawa, T. Nambara
Estriol-16α-glucosiduronate in the urine and serum of pregnant women was measured by a direct radioimmunoassay which was highly specific for this compound and did not require hydrolysis or chromatography. Urinary and serum estriol-16α-glucosiduronate increased as pregnancy progressed. Pregnant women with presumptive renal failure (toxemia of pregnancy, malignant hypertension, post renal transplantation, etc) showed low urinary levels of estriol-16α-glucosiduronate but normal serum levels. Their renal clearance of estriol-16α-glucosiduronate was calculated provisionally and compared to that of creatinine. The results suggest that some serum estriol is conjugated by the kidney and that the measurement of estriol-16α-glucosiduronate can be used as a clinical index of renal failure during pregnancy.
{"title":"Estriol and the Kidney in Pregnancy","authors":"H. Honjo, K. Omori, Takao Yamamoto, Kazuo Otsubo, C. Sakai, K. Tsukamoto, J. Yasuda, M. Fujii, J. Yamaki, H. Okada, M. Numazawa, T. Nambara","doi":"10.1111/J.1447-0756.1981.TB00540.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00540.X","url":null,"abstract":"Estriol-16α-glucosiduronate in the urine and serum of pregnant women was measured by a direct radioimmunoassay which was highly specific for this compound and did not require hydrolysis or chromatography. Urinary and serum estriol-16α-glucosiduronate increased as pregnancy progressed. Pregnant women with presumptive renal failure (toxemia of pregnancy, malignant hypertension, post renal transplantation, etc) showed low urinary levels of estriol-16α-glucosiduronate but normal serum levels. Their renal clearance of estriol-16α-glucosiduronate was calculated provisionally and compared to that of creatinine. The results suggest that some serum estriol is conjugated by the kidney and that the measurement of estriol-16α-glucosiduronate can be used as a clinical index of renal failure during pregnancy.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"30 1","pages":"341-348"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76732675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00517.X
N. Furuhashi, V. Fang
Using mammotropic tumor (MtT/W5) bearing rats as hyperprolactinemia rats, we showed that circulating high prolactin levels caused adrenal hyperplasia. Also, we could clearly demonstrate a positive correlation between the serum levels of prolactin and the adrenal gland weights. The findings suggest that prolactin acts to stimulate primary adrenal hyperplasia.
{"title":"Adrenal Hyperplasia in Hyperprolactinemia Rats","authors":"N. Furuhashi, V. Fang","doi":"10.1111/J.1447-0756.1981.TB00517.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00517.X","url":null,"abstract":"Using mammotropic tumor (MtT/W5) bearing rats as hyperprolactinemia rats, we showed that circulating high prolactin levels caused adrenal hyperplasia. \u0000 \u0000 \u0000 \u0000Also, we could clearly demonstrate a positive correlation between the serum levels of prolactin and the adrenal gland weights. \u0000 \u0000 \u0000 \u0000The findings suggest that prolactin acts to stimulate primary adrenal hyperplasia.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"157 1","pages":"101-105"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74500366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00516.X
S. Takagi, K. Den
This study involved the biosynthesis and metabolism of a series of 16α-hydroxy-steroids and gluco- and mineralocorticoids in the fetus and their concentrations in materno-fetal plasma and amniotic fluid. In the biosynthesis of 16α-hydroxy-steroids, 17α-hydroxylase and C17–20-lyase in the adrenals and 16α-hydroxylase in the liver which are distributed in the microsomal fractions, extremely high activities are observed in 16–20 week fetuses. High sulfokinase activity is also found in the 105,000xg supernatant fraction and the activity in decreasing order is adrenal, liver and small intestine. These enzyme activities are affected by some steroids present in the umbilical plasma. In the biosynthesis of gluco- and mineralocorticoids, 17α-, 21-hydroxylase are distributed in the extramitochondrial fraction of the definitive adrenal cortex while 11β-, 18-hydroxylase and 18-dehydrogenase are in the mitochondrial fraction. All of these enzymes show high activities relatively early in gestation and angiotensin-II shows a selective stimulation for 11β-, 18-hydroxylase and potassium together with ACTH for 18-dehydrogenase. All of the 16α-hydroxy-steroids are consistently higher in the fetal plasma than in maternal plasma and show a 2 to 4 fold increase during the 3rd trimester of gestation. All of corticosteroids assayed are also higher in the fetal plasma and increase during this period. It is well established that a portion of cortisol undergoes sulfate conjugation or conversion to tetrahydro-derivative and that aldosterone is largely converted to 3α' 5β-tetrahydro-aldosterone and a portion undergoes glucosiduronation. Thus, in the fetus, some trophic hormones and endogenous steroids become active in the control of 16α-hydroxy-steroid and corticosteroid biosynthesis and metabolism. In conjunction, the presence of protein bound, unbound fractions as well as sulfate or glucuronide conjugated, unconjugated fractions in the blood tends to maintain an equilibrium and control over these systems.
{"title":"Synthesis and Metabolism of 16α‐Hydroxy‐Steroids and Corticosteroids in Fetuses and Neonates","authors":"S. Takagi, K. Den","doi":"10.1111/J.1447-0756.1981.TB00516.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00516.X","url":null,"abstract":"This study involved the biosynthesis and metabolism of a series of 16α-hydroxy-steroids and gluco- and mineralocorticoids in the fetus and their concentrations in materno-fetal plasma and amniotic fluid. \u0000 \u0000 \u0000 \u0000In the biosynthesis of 16α-hydroxy-steroids, 17α-hydroxylase and C17–20-lyase in the adrenals and 16α-hydroxylase in the liver which are distributed in the microsomal fractions, extremely high activities are observed in 16–20 week fetuses. High sulfokinase activity is also found in the 105,000xg supernatant fraction and the activity in decreasing order is adrenal, liver and small intestine. These enzyme activities are affected by some steroids present in the umbilical plasma. In the biosynthesis of gluco- and mineralocorticoids, 17α-, 21-hydroxylase are distributed in the extramitochondrial fraction of the definitive adrenal cortex while 11β-, 18-hydroxylase and 18-dehydrogenase are in the mitochondrial fraction. All of these enzymes show high activities relatively early in gestation and angiotensin-II shows a selective stimulation for 11β-, 18-hydroxylase and potassium together with ACTH for 18-dehydrogenase. \u0000 \u0000 \u0000 \u0000All of the 16α-hydroxy-steroids are consistently higher in the fetal plasma than in maternal plasma and show a 2 to 4 fold increase during the 3rd trimester of gestation. All of corticosteroids assayed are also higher in the fetal plasma and increase during this period. It is well established that a portion of cortisol undergoes sulfate conjugation or conversion to tetrahydro-derivative and that aldosterone is largely converted to 3α' 5β-tetrahydro-aldosterone and a portion undergoes glucosiduronation. \u0000 \u0000 \u0000 \u0000Thus, in the fetus, some trophic hormones and endogenous steroids become active in the control of 16α-hydroxy-steroid and corticosteroid biosynthesis and metabolism. In conjunction, the presence of protein bound, unbound fractions as well as sulfate or glucuronide conjugated, unconjugated fractions in the blood tends to maintain an equilibrium and control over these systems.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"16 1","pages":"71-98"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89427025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00519.X
K. Ichinoe, Y. Shiina, N. Wake, S. Hoshi
{"title":"CYTOGENETIC STUDIES ON MOLAR GENESIS","authors":"K. Ichinoe, Y. Shiina, N. Wake, S. Hoshi","doi":"10.1111/J.1447-0756.1981.TB00519.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00519.X","url":null,"abstract":"","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"99 1-4 1","pages":"123-134"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83362549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1985.TB00757.X
H. Minakami, K. Kimura, T. Kanazawa, T. Tamada, K. Kaneko
An autops- case of a 32-ear old nulliparous woman who died of acute fatt- liver of pregnanc- (AFLP) associated with h-perlipidemia, acute hemorrhagic pancreatitis and disseminated intravascular coagulation (DIC) is reported. Although acute pancreatitis has been reported as one of the major complications of AFLP, their interrelationships are poorl- understood because of the rarit- and the fulminating nature of this disease. H-perlipidemia has been interpreted as the etiological factor in acute pancreatitis. It is also known that an increase in circulating lipids occurs during pregnanc- ph-siologicall-. AFLP presents itself onl- in the last trimester of pregnanc-. The intention of the following report is to document a case of AFLP with evidence of supra-ph-siologic h-perlipidemia and to discuss the pathogenesis of AFLP and acute pancreatitis.
{"title":"Acute Fatt- Liver of Pregnanc- with H-perlipidemia, Acute Hemorrhagic Pancreatitis and Disseminated Intravascular Coagulation","authors":"H. Minakami, K. Kimura, T. Kanazawa, T. Tamada, K. Kaneko","doi":"10.1111/J.1447-0756.1985.TB00757.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1985.TB00757.X","url":null,"abstract":"An autops- case of a 32-ear old nulliparous woman who died of acute fatt- liver of pregnanc- (AFLP) associated with h-perlipidemia, acute hemorrhagic pancreatitis and disseminated intravascular coagulation (DIC) is reported. Although acute pancreatitis has been reported as one of the major complications of AFLP, their interrelationships are poorl- understood because of the rarit- and the fulminating nature of this disease. H-perlipidemia has been interpreted as the etiological factor in acute pancreatitis. It is also known that an increase in circulating lipids occurs during pregnanc- ph-siologicall-. AFLP presents itself onl- in the last trimester of pregnanc-. The intention of the following report is to document a case of AFLP with evidence of supra-ph-siologic h-perlipidemia and to discuss the pathogenesis of AFLP and acute pancreatitis.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"95 7 1","pages":"371-376"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88397965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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