Pub Date : 2023-08-01DOI: 10.4103/2221-1691.383690
Ru-Chun Yang, Zhou-Ting Wang, Yue-Wen Tang, Feng Wan, Yan Guo, Jie Zheng, You-Gui Li, Wei-Ming He
{"title":"Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis","authors":"Ru-Chun Yang, Zhou-Ting Wang, Yue-Wen Tang, Feng Wan, Yan Guo, Jie Zheng, You-Gui Li, Wei-Ming He","doi":"10.4103/2221-1691.383690","DOIUrl":"https://doi.org/10.4103/2221-1691.383690","url":null,"abstract":"","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":" ","pages":"0 - 0"},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45452150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/2221-1691.380563
Reem Alrashoudi, Manal Abudawood, Ayesha Mateen, H. Tabassum, Noura Alghumlas, S. Fatima, Basmah Almaarik, Farah Maqsood, N. A. Al Musayeib, M. Amina
Objective: To synthesize magnesium oxide nanoparticles using ethanol extract of shoots of Plicosepalus curviflorus (PC-MgONPs) and evaluate the antimicrobial, antioxidant, and anti-proliferative activities of PC-MgONPs. Methods: The green synthesized PC-MgONPs were characterized by ultraviolet-visible (UV), Fourier-transform infrared spectroscopy, zeta potential, energy dispersive X-ray, and scanning electron microscopy. Furthermore, we investigated total antioxidant capacity and antimicrobial and anti-proliferative activities using breast cancer cell lines (MDA-231). Results: The UV spectrum of PC-MgONPs showed a sharp absorption peak at 300 nm. The presence of magnesium, oxygen, and sodium was confirmed by energy dispersive X-ray analysis. Scanning electron microscopy revealed PC-MgONPs as roughly spherical granular structures with sizes ranging from 20.0 to 76.4 nm. PC-MgONPs showed considerable antimicrobial activities against Escherichia coli, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans with zones of inhibition of 11-17 mm. In addition, total antioxidant capacity and anti-proliferative activity of PC-MgONPs against MDA-231 cells were dose-dependent. Conclusions: The synthesized PC-MgONPs could be a potent antimicrobial, antioxidant and anti-cancer agent, which needs further investigation.
{"title":"Characterization and antimicrobial, antioxidant, and anti-proliferative activities of green synthesized magnesium oxide nanoparticles with shoot extracts of Plicosepalus curviflorus","authors":"Reem Alrashoudi, Manal Abudawood, Ayesha Mateen, H. Tabassum, Noura Alghumlas, S. Fatima, Basmah Almaarik, Farah Maqsood, N. A. Al Musayeib, M. Amina","doi":"10.4103/2221-1691.380563","DOIUrl":"https://doi.org/10.4103/2221-1691.380563","url":null,"abstract":"Objective: To synthesize magnesium oxide nanoparticles using ethanol extract of shoots of Plicosepalus curviflorus (PC-MgONPs) and evaluate the antimicrobial, antioxidant, and anti-proliferative activities of PC-MgONPs. Methods: The green synthesized PC-MgONPs were characterized by ultraviolet-visible (UV), Fourier-transform infrared spectroscopy, zeta potential, energy dispersive X-ray, and scanning electron microscopy. Furthermore, we investigated total antioxidant capacity and antimicrobial and anti-proliferative activities using breast cancer cell lines (MDA-231). Results: The UV spectrum of PC-MgONPs showed a sharp absorption peak at 300 nm. The presence of magnesium, oxygen, and sodium was confirmed by energy dispersive X-ray analysis. Scanning electron microscopy revealed PC-MgONPs as roughly spherical granular structures with sizes ranging from 20.0 to 76.4 nm. PC-MgONPs showed considerable antimicrobial activities against Escherichia coli, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans with zones of inhibition of 11-17 mm. In addition, total antioxidant capacity and anti-proliferative activity of PC-MgONPs against MDA-231 cells were dose-dependent. Conclusions: The synthesized PC-MgONPs could be a potent antimicrobial, antioxidant and anti-cancer agent, which needs further investigation.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"315 - 324"},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48697326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/2221-1691.380562
J. Geng, Yanran Shi, Jinsong Su, Juan Wang
Objective: To evaluate the effect of myricetin on ovalbumin (OVA)-induced allergic rhinitis in mice. Methods: Mice were sensitized and challenged using OVA (5%, 500 mL) intraperitoneally and intranasally, respectively, on an alternative day for 14 days, followed by administration of myricetin (50, 100, and 200 mg/kg) till day 21. Nasal symptoms, biochemical parameters, protein expressions, and histopathology were observed. Results: OVA-induced increased nasal symptoms including rubbing, sneezing, and discharge were significantly reduced by myricetin (100 and 200 mg/kg) (P<0.05). Myricetin also protected against histamine challenge and attenuated elevated serum immunoglobulin E (IgE; total and OVA-specific), total IgG1, and β-hexosaminidase levels, as well as leukotriene C4 and interleukins levels in nasal lavage fluid (P<0.05). Western blot analysis showed that myricetin significantly upregulated the protein expression of T-box expressed in T cells, while downregulating the protein expression of GATA binding protein 3, NF-κB, and 1κВ-α (P<0.05). Additionally, OVA-induced histopathological abberations in the nasal mucosa was markedly ameliorated by myricetin treatment (P<0.05). Conclusions: Myricetin exerts anti-allergic effects against OVA-induced allergic rhinitis via regulating Th1/Th2 balance.
{"title":"Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance","authors":"J. Geng, Yanran Shi, Jinsong Su, Juan Wang","doi":"10.4103/2221-1691.380562","DOIUrl":"https://doi.org/10.4103/2221-1691.380562","url":null,"abstract":"Objective: To evaluate the effect of myricetin on ovalbumin (OVA)-induced allergic rhinitis in mice. Methods: Mice were sensitized and challenged using OVA (5%, 500 mL) intraperitoneally and intranasally, respectively, on an alternative day for 14 days, followed by administration of myricetin (50, 100, and 200 mg/kg) till day 21. Nasal symptoms, biochemical parameters, protein expressions, and histopathology were observed. Results: OVA-induced increased nasal symptoms including rubbing, sneezing, and discharge were significantly reduced by myricetin (100 and 200 mg/kg) (P<0.05). Myricetin also protected against histamine challenge and attenuated elevated serum immunoglobulin E (IgE; total and OVA-specific), total IgG1, and β-hexosaminidase levels, as well as leukotriene C4 and interleukins levels in nasal lavage fluid (P<0.05). Western blot analysis showed that myricetin significantly upregulated the protein expression of T-box expressed in T cells, while downregulating the protein expression of GATA binding protein 3, NF-κB, and 1κВ-α (P<0.05). Additionally, OVA-induced histopathological abberations in the nasal mucosa was markedly ameliorated by myricetin treatment (P<0.05). Conclusions: Myricetin exerts anti-allergic effects against OVA-induced allergic rhinitis via regulating Th1/Th2 balance.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"306 - 314"},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43167339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/2221-1691.380559
A. Zanwar, C. Manimurugan, M. Sujatha, A. Rathnakumar, M. Sandhanalakshmi
Seeds of flax or linseed (Linum usitatissimum L.) are important nutraceutical foods with antioxidant, anti-inflammatory, estrogenic, laxative, and antibacterial properties. Flaxseed oil and seeds are the richest vegetarian source of omega-3 fatty acids. Consumption of flaxseeds helps in prevention and control of cardiovascular disease, neurodegenerative disorders, obesity, diabetes mellitus, polycystic ovary syndrome, gout, liver and kidney dysfunction, oxidative stress-related diseases, post-menopausal symptoms, osteoporosis, irritable bowel syndrome, dry eye disease, cystic fibrosis, diarrhea, and cancer, particularly of the mammary and prostate gland cancer. Of late, flaxseed is gaining more importance not only because of its industrial values but also due to its nutraceutical and pharmaceutical properties. The literature review was performed using PubMed, Scopus, PubMed Central, Google Scholar, and Web of Science from 1995 onwards. Data was also obtained from websites/books/book chapters.
亚麻籽或亚麻籽（Linum usitatissimum L.）是重要的营养食品，具有抗氧化、抗炎、雌激素、通便和抗菌特性。亚麻籽油和种子是富含ω-3脂肪酸的素食来源。食用亚麻籽有助于预防和控制心血管疾病、神经退行性疾病、肥胖、糖尿病、多囊卵巢综合征、痛风、肝脏和肾脏功能障碍、氧化应激相关疾病、绝经后症状、骨质疏松症、肠易激综合征、干眼病、囊性纤维化、腹泻和癌症，特别是乳腺和前列腺癌症。最近，亚麻籽变得越来越重要，不仅因为它的工业价值，还因为它的营养和药用特性。从1995年起，使用PubMed、Scopus、PubMed Central、Google Scholar和Web of Science进行文献综述。数据也来自网站/书籍/书籍章节。
{"title":"Role of flaxseed (Linum usitatissimum L.) in disease prevention and treatment","authors":"A. Zanwar, C. Manimurugan, M. Sujatha, A. Rathnakumar, M. Sandhanalakshmi","doi":"10.4103/2221-1691.380559","DOIUrl":"https://doi.org/10.4103/2221-1691.380559","url":null,"abstract":"Seeds of flax or linseed (Linum usitatissimum L.) are important nutraceutical foods with antioxidant, anti-inflammatory, estrogenic, laxative, and antibacterial properties. Flaxseed oil and seeds are the richest vegetarian source of omega-3 fatty acids. Consumption of flaxseeds helps in prevention and control of cardiovascular disease, neurodegenerative disorders, obesity, diabetes mellitus, polycystic ovary syndrome, gout, liver and kidney dysfunction, oxidative stress-related diseases, post-menopausal symptoms, osteoporosis, irritable bowel syndrome, dry eye disease, cystic fibrosis, diarrhea, and cancer, particularly of the mammary and prostate gland cancer. Of late, flaxseed is gaining more importance not only because of its industrial values but also due to its nutraceutical and pharmaceutical properties. The literature review was performed using PubMed, Scopus, PubMed Central, Google Scholar, and Web of Science from 1995 onwards. Data was also obtained from websites/books/book chapters.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"277 - 286"},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47146220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/2221-1691.380560
Yucinda Khor, Siew-Keah Lee, M. Dharmani Devi, W. Ling
Objective: To investigate the effect of epigallocatechin-3-gallate (EGCG) on endothelial dysfunction in spontaneously hypertensive rats (SHR). Methods: Wistar-Kyoto (WKY) rats and SHR were divided into four groups; WKY control, SHR control and SHR treated with EGCG (50 mg/kg/day) or losartan (10 mg/kg/day). The treatment was given daily for 4 weeks by oral gavage and the blood pressure was monitored by tail-cuff method every 3 days. Acetylcholine-induced endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of treatment. The vascular levels of reactive oxygen species, nitric oxide, tetrahydrobiopterin, and cyclic guanosine monophosphate were also measured. Moreover, the expression of angiotensin II type 1 (AT1) receptor protein was determined. Results: The systolic blood pressure was significantly decreased in SHR treated with EGCG. The impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated SHR group. EGCG also significantly increased the levels of nitric oxide, tetrahydrobiopterin, and cyclic guanosine monophosphate, while decreasing the level of reactive oxygen species and the protein expression of AT1 receptor in SHR. Conclusions: EGCG attenuates endothelial dysfunction in SHR by decreasing oxidative stress and increasing vascular nitric oxide bioavailability, which may be modulated partly by inhibition of vascular AT1 receptors. An increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.
{"title":"Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats","authors":"Yucinda Khor, Siew-Keah Lee, M. Dharmani Devi, W. Ling","doi":"10.4103/2221-1691.380560","DOIUrl":"https://doi.org/10.4103/2221-1691.380560","url":null,"abstract":"Objective: To investigate the effect of epigallocatechin-3-gallate (EGCG) on endothelial dysfunction in spontaneously hypertensive rats (SHR). Methods: Wistar-Kyoto (WKY) rats and SHR were divided into four groups; WKY control, SHR control and SHR treated with EGCG (50 mg/kg/day) or losartan (10 mg/kg/day). The treatment was given daily for 4 weeks by oral gavage and the blood pressure was monitored by tail-cuff method every 3 days. Acetylcholine-induced endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of treatment. The vascular levels of reactive oxygen species, nitric oxide, tetrahydrobiopterin, and cyclic guanosine monophosphate were also measured. Moreover, the expression of angiotensin II type 1 (AT1) receptor protein was determined. Results: The systolic blood pressure was significantly decreased in SHR treated with EGCG. The impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated SHR group. EGCG also significantly increased the levels of nitric oxide, tetrahydrobiopterin, and cyclic guanosine monophosphate, while decreasing the level of reactive oxygen species and the protein expression of AT1 receptor in SHR. Conclusions: EGCG attenuates endothelial dysfunction in SHR by decreasing oxidative stress and increasing vascular nitric oxide bioavailability, which may be modulated partly by inhibition of vascular AT1 receptors. An increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"287 - 295"},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43789664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.4103/2221-1691.380561
Shamsher Singh, K. Aran, G. Gupta
Objective: To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats. Methods: Rats were administered with cladribine (1 mg/kg, p.o.) and cryptotanshinone (10 and 20 mg/kg, i.p.) for four weeks. Behavioral tests such as Morris water maze and elevated plus maze were conducted to check memory impairment caused by cladribine. On day 29, all rats were sacrificed, and the brains were separated for estimation of neuroinflammatory factors, biochemical parameters, neurotransmitters, Aβ(1-42), blood-brain barrier permeability, nuclear factor erythroid 2-related factor 2 (Nrf2), and brain-derived neurotrophic factor (BDNF). Results: Treatment with cryptotanshinone dose-dependently enhanced spatial memory, improved the levels of neurotransmitter and antioxidant enzymes, and suppressed proinflammatory cytokine release. Cryptotanshinone also decreased Aβ(1-42) accumulation and increased the levels of Nrf2 and BDNF in the hippocampus. Additionally, the histopathological results showed that cryptotanshinone reduced cladribine-induced neuronal death in the hippocampus. Conclusions: Cryptotanshinone exhibits a promising neuroprotective effect against cladribine-induced cognitive impairment in preclinical studies, and may be a potential phytochemical for the treatment and management of cognitive impairment.
{"title":"Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats","authors":"Shamsher Singh, K. Aran, G. Gupta","doi":"10.4103/2221-1691.380561","DOIUrl":"https://doi.org/10.4103/2221-1691.380561","url":null,"abstract":"Objective: To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats. Methods: Rats were administered with cladribine (1 mg/kg, p.o.) and cryptotanshinone (10 and 20 mg/kg, i.p.) for four weeks. Behavioral tests such as Morris water maze and elevated plus maze were conducted to check memory impairment caused by cladribine. On day 29, all rats were sacrificed, and the brains were separated for estimation of neuroinflammatory factors, biochemical parameters, neurotransmitters, Aβ(1-42), blood-brain barrier permeability, nuclear factor erythroid 2-related factor 2 (Nrf2), and brain-derived neurotrophic factor (BDNF). Results: Treatment with cryptotanshinone dose-dependently enhanced spatial memory, improved the levels of neurotransmitter and antioxidant enzymes, and suppressed proinflammatory cytokine release. Cryptotanshinone also decreased Aβ(1-42) accumulation and increased the levels of Nrf2 and BDNF in the hippocampus. Additionally, the histopathological results showed that cryptotanshinone reduced cladribine-induced neuronal death in the hippocampus. Conclusions: Cryptotanshinone exhibits a promising neuroprotective effect against cladribine-induced cognitive impairment in preclinical studies, and may be a potential phytochemical for the treatment and management of cognitive impairment.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"296 - 305"},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42523390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.4103/2221-1691.378597
Oluwakemi Adeleke, Stephen Adeniyi Adefegha, G. Oboh
Wound repair is noticeably prolonged in a diabetic state due to a faulty inflammatory process and an underlying neuropathy. Several medicinal plants and their products have been of prime importance for the management of wounds over the years. Various mechanisms whereby medicinal plants elicit their action in wound repair are revealed and some plants are proven to be experimentally effective in enhancing wound closure and achieving healing. The mechanisms identified include hyperglycemic control, alleviation of physiological inflammation, controlled oxidative stress, infection control, and influence on gene expression. Information in this review was sourced from research and review articles in electronic databases such as Web of Science, Scopus, PubMed, and Google Scholar.
在糖尿病状态下，由于炎症过程和潜在的神经病变，伤口修复明显延长。多年来，几种药用植物及其产品对伤口的管理至关重要。揭示了药用植物在伤口修复中发挥作用的各种机制，一些植物在实验中被证明在增强伤口闭合和实现愈合方面是有效的。确定的机制包括控制高血糖、减轻生理炎症、控制氧化应激、控制感染和影响基因表达。本综述中的信息来源于Web of Science、Scopus、PubMed和Google Scholar等电子数据库中的研究和综述文章。
{"title":"Mechanisms of medicinal plants in the treatment of diabetic wound","authors":"Oluwakemi Adeleke, Stephen Adeniyi Adefegha, G. Oboh","doi":"10.4103/2221-1691.378597","DOIUrl":"https://doi.org/10.4103/2221-1691.378597","url":null,"abstract":"Wound repair is noticeably prolonged in a diabetic state due to a faulty inflammatory process and an underlying neuropathy. Several medicinal plants and their products have been of prime importance for the management of wounds over the years. Various mechanisms whereby medicinal plants elicit their action in wound repair are revealed and some plants are proven to be experimentally effective in enhancing wound closure and achieving healing. The mechanisms identified include hyperglycemic control, alleviation of physiological inflammation, controlled oxidative stress, infection control, and influence on gene expression. Information in this review was sourced from research and review articles in electronic databases such as Web of Science, Scopus, PubMed, and Google Scholar.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"233 - 241"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47832713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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