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A Hierarchy of Medical Countermeasures Against Biological Threats. 针对生物威胁的一系列医学对策。
Pub Date : 2022-03-28 DOI: 10.1093/milmed/usac077
Adam T. Biggs, Lanny F. Littlejohn
INTRODUCTIONEmerging biological threats represent a serious challenge for force health protection (FHP). Against a novel biological threat, medical countermeasures are the first line of defense. However, as exposed by global pandemic conditions, there are significant complications when administering medical countermeasures against novel threats. One such limitation involved the lack of any guiding structure to discuss and deliberate upon the relative value of employing different countermeasures either alone or in tandem. For example, both personal protective equipment and prophylactic medication can provide some protection, but how are individual protections weighed against operational capabilities and FHP initiatives? The goal of this review is to provide a hierarchical organizing structure to the different medical countermeasures available in response to emerging biological threats.MATERIALS AND METHODSThis review used no explicit inclusion or exclusion criteria for its literature review. References are provided for illustrative purposes to represent different components of the medical hierarchy.DISCUSSIONThe hierarchy presented here is organized around a resource-durability structure that functions as a push-pull mechanism. Specifically, lower levels of the hierarchy require more resources to sustain FHP conditions while also providing less durable protection. These countermeasures require continual reapplication, and so resources become conceived as much in time and effort to apply as in exhaustible supplies. Higher-order countermeasures require less resources investment as a single application can provide weeks, months, or years of protection. Moreover, higher-order protections are less likely to interfere with military operational capabilities, which further support their classification as superior countermeasures to sustain FHP. The five levels of the hierarchy are presented here as follows, organized from lowest to highest value as a medical countermeasure: (1) Sanitization, (2) personal protective equipment, (3) prophylaxis, (4) vaccines, and (5) optimized immune system. Rationale and descriptions identify how each higher-order countermeasure is superior to its lower-order counterparts while noting that optimizing FHP will likely require employing multiple countermeasures at different levels. The discussion concludes with an overview as to how different countermeasures were employed to various degrees during a novel global pandemic.CONCLUSIONS AND FUTURE USESIdentifying medical countermeasures is important to optimizing FHP. Different countermeasures have different advantages, and the hierarchy distinguishes between inferior and superior countermeasures through the push-pull style mechanism of resource-durability assessment. Future deployment and development should focus on superior countermeasures to maximize medical protections and operational readiness while understanding the relative value and complications inherent with
新出现的生物威胁是部队健康保护(FHP)面临的严峻挑战。面对新的生物威胁,医疗对策是第一道防线。然而,由于全球大流行的情况,在管理针对新威胁的医疗对策时存在严重的并发症。其中一个限制是缺乏任何指导结构来讨论和审议单独或同时采用不同对策的相对价值。例如,个人防护装备和预防性药物都可以提供一定的保护,但个人防护如何与操作能力和FHP计划相权衡?本综述的目的是为应对新出现的生物威胁提供不同的医疗对策的分层组织结构。材料和方法本综述未使用明确的纳入或排除标准进行文献综述。本文提供的参考文献是为了说明医学层次结构的不同组成部分。这里呈现的层次结构是围绕一个资源耐久性结构组织的,该结构的功能类似于推拉机制。具体来说,较低层次需要更多的资源来维持FHP条件,同时也提供较不持久的保护。这些对策需要不断地重新应用,因此资源在时间和精力上的应用与在可耗尽的供应上的应用是一样多的。高阶对策需要较少的资源投资,因为单个应用程序可以提供数周、数月或数年的保护。此外,高阶保护不太可能干扰军事作战能力,这进一步支持将其归类为维持FHP的高级对策。作为医疗对策,从最低到最高的价值按五个层次排列如下:(1)卫生处理,(2)个人防护装备,(3)预防,(4)疫苗,(5)优化免疫系统。基本原理和描述确定了每个高阶对策如何优于低阶对策,同时注意到优化FHP可能需要在不同级别采用多种对策。讨论最后概述了在新的全球大流行期间如何在不同程度上采用不同的对策。结论及未来应用明确医疗对策对优化FHP具有重要意义。不同的对策具有不同的优势,并通过推拉式的资源耐久性评价机制来区分优劣对策。未来的部署和发展应侧重于更好的对策,以最大限度地提高医疗保护和作战准备程度,同时了解不同对策的相对价值和内在复杂性。
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引用次数: 2
Letter From the Executive Director Dr. John Cho. 执行主任赵约翰博士的信。
Pub Date : 2022-03-28 DOI: 10.1093/milmed/usac076
John M. Cho
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引用次数: 0
Cause-Specific Mortality Among Norwegian Veterans Deployed to Afghanistan Between 2001 and 2019. 2001年至2019年期间部署到阿富汗的挪威退伍军人的死因特定死亡率。
Pub Date : 2022-03-26 DOI: 10.1093/milmed/usac075
Leif Åge Strand, Inger Rudvin, Einar Kristian Borud, Hans Jakob Bøe, Andreas Espetvedt Nordstrand, Elin Anita Fadum

Introduction: Norwegian military forces participated in the military campaign Operation Enduring Freedom in Afghanistan starting in 2001. Military personnel often show a "healthy soldier effect" in terms of lowered all-cause mortality when compared to the general population. However, military service in conflict areas is associated with an increased risk of death from external causes such as transport accidents and suicide after discharge. We aimed to investigate cause-specific mortality in a cohort of 9,192 Norwegian (7.5% women) veterans deployed to Afghanistan between 2001 and 2019.

Materials and methods: We followed cohort members from their first day of service in Afghanistan through 2019. We computed standardized mortality ratios (SMRs) with 95% CIs by comparing the observed number of deaths in our cohort with the expected number of deaths in the general population. Standardized mortality ratios were calculated for the full follow-up period among men and women separately, and among men only for two time periods: during deployment and after discharge from service in Afghanistan.

Results: We observed 77 deaths (3 women and 74 men), 10 of which occurred during deployment (war casualties, 1 woman and 9 men); all others occurred after discharge. All-cause mortality in women did not differ from that in the general population (SMR = 0.52, 95% CI 0.11-1.53). For men, the observed all-cause mortality was lower than the expected rate for the full follow-up period (SMR = 0.55, 95% CI 0.43-0.69), during deployment, and after discharge, while deaths because of transport accidents after discharge (13 cases) were more than twice as high as expected rates (SMR = 2.36, 95% CI 1.26-4.04). The 11 observed suicides gave a nonstatistically significant, lower suicide risk compared to the expected rates (SMR = 0.66, 95% CI 0.33-1.18).

Conclusion: In accordance with the "healthy soldier effect," military service in Afghanistan was generally associated with a lower than expected risk of death both during deployment and after discharge. The risk of death from transport accidents was higher than expected after discharge, while the observed incidence of suicide did not differ from the expected rate in the general population.

简介挪威军队参加了2001年开始的在阿富汗的“持久自由行动”军事行动。与普通人群相比,军事人员在降低全因死亡率方面往往表现出“健康士兵效应”。然而,在冲突地区服兵役会增加因运输事故和退伍后自杀等外部原因死亡的风险。我们旨在调查2001年至2019年间部署到阿富汗的9192名挪威退伍军人(7.5%为女性)的病因特异性死亡率。材料和方法我们从队列成员在阿富汗服役的第一天到2019年对他们进行了跟踪调查。通过比较我们队列中观察到的死亡人数与普通人群中的预期死亡人数,我们计算了95%置信区间的标准化死亡率(SMR)。在整个随访期间,分别计算了男性和女性的标准化死亡率,仅计算了两个时间段的男性死亡率:在阿富汗部署期间和退役后。我们观察到77人死亡(3名女性和74名男性),其中10人发生在部署期间(战争伤亡,1名女性和9名男性);其他均发生在出院后。妇女的全因死亡率与普通人群没有差异(SMR = 0.52,95%CI 0.11-1.53)。对于男性,观察到的全因死亡率低于整个随访期的预期死亡率(SMR = 0.55,95%CI 0.43-0.69),而出院后因运输事故死亡(13例)是预期死亡率的两倍多(SMR = 2.36,95%CI 1.26-4.04)。观察到的11名自杀者的自杀风险比预期的自杀率低(SMR = 0.66,95%CI 0.33-1.18)。结论根据“健康士兵效应”,在阿富汗服役通常与部署期间和退伍后的死亡风险低于预期有关。出院后死于交通事故的风险高于预期,而观察到的自杀发生率与普通人群的预期发生率没有差异。
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引用次数: 0
Response to Letter to the Editor on Concerning the Occupational Military Neuromusculoskeletal Injury Matrix. 关于职业性军事神经肌肉骨骼损伤矩阵致编辑信的回复。
Pub Date : 2022-03-17 DOI: 10.1093/milmed/usac068
T. Roy, Melissa D Richardson, B. Ritland, Robin E Cushing, Vy-Tuong Nguyen
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引用次数: 0
The Hospital Ship as a Strategic Asset in21st Century Foreign Policy and Global Health Crises. 医院船作为21世纪外交政策和全球卫生危机中的战略资产。
Pub Date : 2022-03-17 DOI: 10.1093/milmed/usac061
M. S. Baker, Jacob B Baker, F. Burkle
INTRODUCTIONCurrent U.S. hospital ships-USNS Mercy and Comfort-are old, slow, cumbersome, and indefensible, and due for retirement. As new challenges and new threats emerge in the 21st century, the U.S. Navy should field new afloat medical platforms to potentially deal with both mass casualty scenarios and humanitarian disaster relief in a rapid and tactical manner. New hospital ships should be able to defend themselves with more modern weapons and to be interconnected with encrypted communications. They must be fast, nimble, tactical, defensible, and forward deployed in the risky global commons of the 21st century.MATERIALS AND METHODSSystematic review of the literature on hospital ships, U.S. Navy policy, the Geneva Conventions, and current global threat conditions.RESULTSHospital ships provide medical support for U.S. forces in conflict and promote goodwill and a positive image of the U.S. abroad. Current hospital ships do not fit the operational paradigm of the current needs for forward deployed and rapidly deliverable operational medicine. There is a need for a new and more capable platform to deliver operational health care in the forward deployed setting.CONCLUSIONSMultiple high-speed medical response vessels-whether reconfigured from an existing ship, or an entirely new platform developed for more robust medical delivery-need to be urgently fielded for future combat operations, humanitarian missions, and participation in cooperative security engagements. These medical platforms need to be able to defend themselves and be tactically interconnected with the Fleet and Fleet Forces.
当前的美国医院船——美国海军“仁慈”号和“舒适”号——老旧、缓慢、笨重、无法防御,即将退役。随着21世纪新挑战和新威胁的出现,美国海军应该部署新的海上医疗平台,以快速和战术的方式处理大规模伤亡情景和人道主义灾难救援。新的医疗船应该能够用更现代化的武器来保护自己,并通过加密通信相互连接。它们必须快速、灵活、战术、可防御,并在21世纪危险的全球公域中向前部署。材料和方法系统回顾了医院船、美国海军政策、日内瓦公约和当前全球威胁状况的文献。结果医院船为冲突中的美军提供医疗支持,促进美国在海外的友好和积极形象。目前的医院船不适合当前对前沿部署和快速交付的操作医学需求的操作范式。需要一种新的、能力更强的平台,在前沿部署环境中提供可操作的医疗保健服务。多艘高速医疗响应船——无论是从现有舰船上重新配置,还是为更强大的医疗交付而开发的全新平台——都需要紧急部署,用于未来的作战行动、人道主义任务和参与合作安全交战。这些医疗平台需要能够自我防御,并在战术上与舰队和舰队部队相互联系。
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引用次数: 1
A Commentary. 一个评论。
Pub Date : 2022-03-17 DOI: 10.1093/milmed/usac062
Bruce J. Gillingham, Christopher Kurtz, D. Daniels, K. Marler, Amal Robertson
Most people spend a large part of their lives working. It is, perhaps, inevitable that workplace environments help to shape people’s well-being and happiness. As we reflect on the past 20 years of Media & Jornalismo research we must also look forward to the future of journalism and consider how research can contribute to that future. We also should consider a possible paradigmatic shift in journalism studies and practice that de-focuses journalism and considers the humanity of journalism workers, seeing them less as commodities or commodifiable and more as complex individuals calling for and deserving of personal and professional well-being.
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引用次数: 0
The Effectiveness of a Standardized Ice-Sheet Cooling Method Following Exertional Hyperthermia. 运动高温后标准化冰盖冷却方法的有效性。
Pub Date : 2022-03-16 DOI: 10.1093/milmed/usac047
Aaron R. Caldwell, Michelle M. Saillant, Dina M. Pitsas, Audrey Johnson, K. Bradbury, N. Charkoudian
INTRODUCTIONExertional heat illnesses remain a major threat to military service members in the United States and around the world. Exertional heat stroke (EHS) is the most severe heat illness, characterized by core hyperthermia and central nervous system dysfunction. Per current Army regulations, iced-sheet cooling (ISC) is the recommended immediate treatment for heat casualties in the field, but concerns have been raised regarding the efficacy of this approach. Thus, the purpose of this study was to quantify the cooling rate of ISC following exertional hyperthermia.MATERIALS AND METHODSWe utilized a randomized crossover design with 2 experimental trials. In both trials, exertional hyperthermia was induced by walking (3.5 mph at 5% grade) on a treadmill in an environmental chamber (40 °C, 30% RH) for up to 3 hours or until core body temperature reached 39.2 °C. After the walking portion, individuals either received ISC (experimental trial) or cooling and rested supine in the same environmental conditions for 30 minutes with no ISC (control trial). For ISC, bed sheets soaked in ice water were applied (per Army guidance) at the neck, chest, and groin with another sheet covering the body. Sheets were rotated and resoaked every 3 minutes until core temperature decreased to <38.0 °C.RESULTSBy design, participants finished exercise with increased core temperature (38.8 ± 0.39 °C vs. 38.90 ± 0.34 °C, ISC and control trials, P = 1.00). The ISC trial provided significantly (P = .023) greater cooling rates, 0.068 °C/min 95% confidence interval [CI; 0.053, 0.086], compared to the control trial, 0.047 °C/min 95% CI [0.038, 0.056]. Additionally, the time to decrease to less than 38.0 °C was significantly (P = .018) faster in the ISC trial (median = 9.3 minutes) compared to the control trial (median = 26.6 minutes).CONCLUSIONISC increases the cooling rate of those recovering from exertional hyperthermia. With the observed cooling rate, we can extrapolate that ISC would reduce core temperature by ∼2 °C within 30 minutes during a case of EHS. We conclude that ISC provides a safe and effective alternative for the field where cold water immersion resources may not be readily available.
劳累性中暑仍然是美国和世界各地军人面临的主要威胁。劳损性中暑(EHS)是最严重的中暑疾病,以核心热疗和中枢神经系统功能障碍为特征。根据目前的陆军条例,冰原冷却(ISC)是建议立即治疗现场热伤亡的方法,但人们对这种方法的有效性提出了担忧。因此,本研究的目的是量化运动热疗后ISC的冷却速率。材料与方法采用随机交叉设计,2项试验。在这两项试验中,通过在环境室(40°C, 30% RH)的跑步机上行走(3.5英里/小时,5%坡度)长达3小时或直到核心体温达到39.2°C来诱导劳累性热疗。步行部分结束后,受试者接受ISC(实验试验)或在相同的环境条件下冷却并仰卧休息30分钟,不进行ISC(对照试验)。对于ISC,在颈部,胸部和腹股沟处(根据军队指导)使用浸泡在冰水中的床单,另一张床单覆盖身体。每隔3分钟将薄片旋转并重新浸泡一次,直到核心温度降至<38.0°C。结果通过设计,参与者在完成运动时核心温度升高(38.8±0.39°C vs. 38.90±0.34°C, ISC和对照试验,P = 1.00)。ISC试验提供了显著(P = 0.023)更大的冷却速率,0.068°C/min 95%置信区间[CI;0.053, 0.086],与对照试验相比,0.047°C/min 95% CI[0.038, 0.056]。此外,与对照试验(中位数= 26.6分钟)相比,ISC试验(中位数= 9.3分钟)降低至低于38.0°C的时间显著(P = 0.018)快。结论:c可提高运动热疗恢复期的降温速度。根据观察到的冷却速度,我们可以推断,在EHS的情况下,ISC可以在30分钟内将核心温度降低~ 2°C。我们的结论是,ISC为冷水浸泡资源可能不容易获得的领域提供了一种安全有效的替代方案。
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引用次数: 4
Correction To: Femoral Nerve Blockade Does Not Lead to Subjective Functional Deficits After Anterior Cruciate Ligament Reconstruction. 更正:股神经阻断不会导致前交叉韧带重建后的主观功能缺陷。
Pub Date : 2022-03-16 DOI: 10.1093/milmed/usac070
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引用次数: 0
Health Conditions Among Navy Submariners at the End of Active Duty; A Retrospective Cohort Study. 美国海军退役潜艇艇员健康状况研究回顾性队列研究。
Pub Date : 2022-03-12 DOI: 10.1093/milmed/usac063
Brian J Maguire, Linda M Hughes, Douglas C McAdams, Michael Gilbert, Robert Nordness

Introduction: Maintaining healthy, well-trained, and highly qualified armed forces is critical for ensuring military readiness. The purpose of this article is to contribute to the body of research focused on the health of U.S. Navy submariners and to identify the health conditions of U.S. Navy submariners during their final year of active duty service.

Materials and methods: In this retrospective cohort study, we examined medical records and personnel files of separating U.S. Navy sailors who were: (1) active duty between 2009 and 2018; (2) separated before 2019; and (3) were assigned to a submarine for at least 30 days. Both officers and enlisted service members were included. We linked, described, and analyzed data from the Defense Health Agency, Military Health System Data Repository (MDR), and the Bureau of Naval Personnel (BUPERS). International Classification of Diseases (ICD) diagnoses codes were obtained from MDR. Data collected from BUPERS include age, sex, and rank. We determined the number of individuals who had at least one diagnosed condition (identified as a three-digit ICD code). We report the number of diagnoses and calculate prevalence rates and confidence intervals per condition, as well as prevalence rates per year, using standard formulas. The study was approved by the Naval Submarine Medical Research Laboratory Institutional Review Board.

Results: During the study period, 26,014 submariners separated from the Navy. The average number of separations per year was 2,601. About a third of the separating submariners were in the 25 to 29 age group and over 50% were under 30 years of age. Of the three-digit individual ICD codes, some of the highest operationally relevant rates over the 10-year study period (2009-2018) were for joint disorders (prevalence rate [PR] = 180 per 1,000 submariners), back disorders (PR = 128), and sleep disorders (PR = 134). Three mental-health-related conditions were also among the 20 conditions with the highest rates.

Conclusions: High rates of specific diagnoses such as joint disorders indicate the need for additional study to examine causal relationships, to determine which conditions may contribute to lost work time, early separations, or low rates of reenlistment and which conditions might be a result of specific military occupations or duties. Study strengths are the large number of subjects and the long period of observations. A study weakness was the inability to identify submariners who separated because of health conditions. The overall impact of the study is that it identifies urgent health risks and establishes a way to prioritize future research. Future research should include a focus on medically separated personnel; compare rates for submariners to other military groups including all-Navy and all-Department of Defense; and determine specific and relative risks as a necessary precursor to developing, imp

保持健康、训练有素和高素质的武装部队是确保军事准备的关键。这篇文章的目的是为美国海军潜艇艇员健康的研究机构做出贡献,并确定美国海军潜艇艇员在现役服务的最后一年的健康状况。材料与方法在这项回顾性队列研究中,我们检查了美国海军退役水手的医疗记录和人事档案,他们:(1)2009年至2018年现役;(2) 2019年前分居;(3)被分配到潜艇上至少30天。军官和士兵都包括在内。我们链接、描述并分析了来自国防卫生机构、军事卫生系统数据存储库(MDR)和海军人事局(BUPERS)的数据。国际疾病分类(ICD)诊断代码由多药耐药获得。从BUPERS收集的数据包括年龄、性别和级别。我们确定了至少有一种诊断病症(以三位数ICD代码标识)的个体数量。我们使用标准公式报告诊断的数量,并计算每种疾病的患病率和置信区间,以及每年的患病率。这项研究得到了海军潜艇医学研究实验室机构审查委员会的批准。结果在研究期间,26,014名潜艇兵脱离了海军。每年平均离职人数为2 601人。大约三分之一的分离潜艇艇员年龄在25至29岁之间,超过50%的艇员年龄在30岁以下。在三位数的个体ICD代码中,在10年研究期间(2009-2018年),与操作相关的最高发病率是关节疾病(患病率[PR] = 180 / 1000)、背部疾病(患病率= 128)和睡眠障碍(患病率= 134)。在20种疾病中,三种与精神健康相关的疾病也是发病率最高的。结论:关节疾病等特殊诊断的高比例表明需要进一步研究因果关系,以确定哪些情况可能导致失去工作时间、提前离职或低重新入伍率,哪些情况可能是特定军事职业或职责的结果。研究的优势在于研究对象多,观察时间长。研究的一个弱点是无法确定因健康状况而分离的潜艇兵。这项研究的总体影响是,它确定了紧急的健康风险,并确定了优先考虑未来研究的方法。未来的研究应包括对医学隔离人员的关注;将潜艇的费率与其他军事团体进行比较,包括全海军和全国防部;确定具体的和相对的风险,作为制定、实施和测试降低风险和改善健康干预措施的必要先导。
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引用次数: 0
Learning to Lead: 10 Leadership Lessons From Operation Bushmaster.
Pub Date : 2022-03-12 DOI: 10.1093/milmed/usac058
John G Blickle, Leslie Vojta, Che-Sheu Huang, Jacob M Wyse, A. Yarnell, Joshua D. Hartzell
Medical students at the Uniformed Services University of the Health Sciences participate in a leadership curriculum designed to develop leadership skills. Operation Bushmaster is a 5-day field practicum designed to test these skills. In this article, we describe 10 leadership lessons learned during Operation Bushmaster applicable to all leaders.
卫生科学统一服务大学的医学生参加了旨在培养领导技能的领导课程。“大毒蛇”行动是一项为期5天的实地实习,旨在测试这些技能。在这篇文章中,我们描述了在“大毒蛇”行动中所学到的适用于所有领导人的10条领导力教训。
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引用次数: 1
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Military surgeon
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