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Race Differences in Veteran's Affairs Emergency Department Utilization. 退伍军人事务急诊科使用率的种族差异
Pub Date : 2023-11-03 DOI: 10.1093/milmed/usac152
Shamira J Rothmiller, Brian C Lund, Diana J Burgess, Sangil Lee, Katherine Hadlandsmyth

Introduction: African Americans (AAs) experience disparities in chronic pain care. This study aimed to identify the rates of emergency department (ED) utilization for visits associated with chronic pain diagnoses among AAs compared to Whites and to determine variables that accounted for any differences.

Methods: This retrospective observational study used national Veterans Affairs (Veteran's Health Administration) administrative data to identify Veterans with chronic pain diagnoses in 2018. Race/ethnicity was self-reported and assessed to examine if differences exist in ED utilization. Differences between AAs and Whites were examined using negative binomial regression models, controlling for ethnicity. Multivariable models (including demographics, pain characteristics, psychiatric comorbidities, medical comorbidities, pain-related health care utilization, and medication utilization) were examined to determine factors that contributed to these disparities.

Results: Among the 2,261,030 patients, 22% (n = 492,138) were AA. The incidence rate ratio of ED utilization for AAs, relative to Whites, was 1.58 (95% CI: 1.56-1.59). The only independent variable that produced a clinically meaningful reduction in the race effect on ED use was rurality, which was associated with reduced ED use. Post hoc model including all variables reduced the race effect to 1.37 (95% CI: 1.36-1.38).

Conclusion: AA Veterans had a 58% greater risk of ED utilization for visits associated with chronic pain diagnoses relative to White Veterans, which remained meaningfully elevated after adjustment for observable confounders (37%). This observation may reflect disparities in outpatient chronic pain care for AAs. Future research could focus on enhancing therapeutic alliance in primary care to improve chronic pain treatment for AAs.

引言非裔美国人在慢性疼痛护理方面存在差异。本研究旨在确定AAs与白人相比,急诊科(ED)与慢性疼痛诊断相关的就诊率,并确定解释任何差异的变量。方法本回顾性观察性研究使用国家退伍军人事务局(退伍军人健康管理局)的行政数据来确定2018年被诊断为慢性疼痛的退伍军人。对种族/民族进行自我报告和评估,以检查ED利用率是否存在差异。AAs和白人之间的差异使用负二项回归模型进行检验,并控制种族。研究了多变量模型(包括人口统计学、疼痛特征、精神合并症、医学合并症、疼痛相关的医疗保健利用率和药物利用率),以确定导致这些差异的因素。结果2261030例患者中 = 492138)为AA。相对于白人,AAs的ED利用率为1.58(95%CI:1.56-1.59)。唯一对ED使用的种族效应产生临床意义降低的自变量是农村,这与ED使用的减少有关。包括所有变量的事后模型将种族效应降低到1.37(95%可信区间:1.36-1.38)。结论与白人退伍军人相比,退伍军人在与慢性疼痛诊断相关的就诊中使用ED的风险高58%,在调整了可观察的混杂因素后,这一风险仍显著升高(37%)。这一观察结果可能反映了AAs门诊慢性疼痛护理的差异。未来的研究可以集中在加强初级保健中的治疗联盟,以改善AAs的慢性疼痛治疗。
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引用次数: 1
Diagnostic Accuracy of the Boston Assessment of Traumatic Brain Injury-Lifetime Clinical Interview Compared to Department of Defense Medical Records. 创伤性脑损伤波士顿评估的诊断准确性-与国防部医疗记录的终生临床访谈比较。
Pub Date : 2023-11-03 DOI: 10.1093/milmed/usac162
Sahra Kim, Alyssa Currao, Jennifer R Fonda, Brigitta Beck, Alexandra Kenna, Catherine B Fortier

Introduction: Since 2006, efforts have been made to increase the accurate identification of traumatic brain injuries (TBIs) in post-9/11 military personnel. The Boston Assessment of TBI-Lifetime (BAT-L) is the first validated instrument designed specifically to diagnose TBIs throughout the life span in post-9/11 Veterans. The objective was to compare the diagnostic accuracy of the BAT-L with medical records from the Department of Defense (DoD).

Material and methods: Traumatic brain injury diagnosis for 153 Veterans deployed in 2011 enrolled in the Translational Research Center for TBI and Stress Disorder longitudinal cohort study from the BAT-L clinical interview was compared to DoD online medical records to determine diagnostic prevalence and injury severity for all head injury cases during deployment. Sensitivity, specificity, Cohen's kappa, and Kendall's tau-b were calculated for TBI diagnosis and severity. Concordant TBI cases and discordant TBI cases were compared using chi-square and t-test analyses. This study has been approved by VA Boston by Institutional Review Boards for human participants' protection.

Results: Correspondence of TBI diagnoses from the BAT-L with DoD records was fair (κ = 0.42; sensitivity = 72.7%; specificity = 82.8%). Comparison of injury severity also showed fair correspondence (κ = 0.41). Missing TBI diagnostic data from DoD records were frequent; 43% of TBIs reported on the BAT-L did not have any documentation of assessment or diagnoses in DoD records.

Conclusion: This study addresses a critical gap in research by comparing the diagnostic accuracy of a validated, semi-structured clinical interview with available medical records. Diagnosis of TBIs via the BAT-L was both sensitive and specific when compared to DoD records, supporting the validity of the BAT-L for retrospective assessment of military TBI. However, diagnostic correspondence was only fair. This lack of diagnostic agreement was related to multiple factors including lack of documentation at the time of injury by DoD, differences in assessment and goals, and other combat-related motivational factors associated with failure to report injuries while deployed. Several policies have been implemented to address underreporting and under-documentation of TBIs, yet challenges remain. Recommendations for evaluating TBI are presented. Accurate diagnosis of TBI is necessary for appropriate treatment planning, as well as service-related compensation.

引言自2006年以来,一直在努力提高对9/11后军事人员创伤性脑损伤的准确识别。波士顿脑外伤终身评估(BAT-L)是第一个经过验证的专门用于诊断9/11后退伍军人终身脑外伤的仪器。目的是将BAT-L的诊断准确性与国防部的医疗记录进行比较。材料和方法将BAT-L临床访谈中的153名退伍军人的创伤性脑损伤诊断与国防部在线医疗记录进行对比确定部署期间所有头部损伤病例的诊断患病率和损伤严重程度。计算TBI诊断和严重程度的敏感性、特异性、Cohen’s kappa和Kendall’s tau-b。使用卡方和t检验分析比较一致性脑外伤病例和不一致性脑梗塞病例。这项研究已获得弗吉尼亚大学波士顿分校机构审查委员会的批准,以保护人类参与者。结果BAT-L的TBI诊断与DoD记录的相关性尚可(κ = 0.42;体贴 = 72.7%;特异性 = 82.8%)。损伤严重程度的比较也显示出相当的对应性(κ = 0.41)。国防部记录中的TBI诊断数据经常缺失;BAT-L报告的43%的TBI在国防部记录中没有任何评估或诊断文件。结论本研究通过将经过验证的半结构化临床访谈的诊断准确性与现有医疗记录进行比较,解决了研究中的一个关键差距。与国防部记录相比,通过BAT-L诊断TBI既敏感又特异,支持了BAT-L对军事TBI回顾性评估的有效性。然而,诊断对应只是公平的。这种诊断协议的缺乏与多种因素有关,包括国防部在受伤时缺乏文件、评估和目标的差异,以及与部署时未报告受伤相关的其他与战斗相关的动机因素。已经实施了一些政策来解决TBI报告不足和文件编制不足的问题,但挑战依然存在。提出了评估TBI的建议。TBI的准确诊断对于适当的治疗计划以及与服务相关的补偿是必要的。
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引用次数: 1
Symptoms and Central Sensory Integration in People With Chronic mTBI: Clinical Implications. 慢性mTBI患者的症状和中枢感觉统合:临床意义
Pub Date : 2023-11-03 DOI: 10.1093/milmed/usac157
Douglas N Martini, Geetanjali Gera, Barbara H Brumbach, Kody R Campbell, Lucy Parrington, James Chesnutt, Laurie A King

Introduction: Balance deficits in people with chronic mild traumatic brain injury (mTBI; ≥3 months post-mTBI), thought to relate to central sensory integration deficits, are subtle and often difficult to detect. The purpose of this study was to determine the sensitivity of the instrumented modified clinical test of sensory integration for balance (mCTSIB) in identifying such balance deficits in people with symptomatic, chronic mTBI and to establish the associations between balance and mTBI symptom scores in the chronic mTBI group.

Methods: The Institutional Review Board approved these study methods. Forty-one people with chronic mTBI and balance complaints and 53 healthy controls performed the mCTSIB (eyes open/closed on firm/foam surfaces; EoFi, EcFi, EoFo, and EcFo) with a wearable sensor on their waist to quantify sway area (m2/s4). Sensory reweighting variables were calculated for the firm and foam stance conditions. A stopwatch provided the clinical outcome for the mCTSIB (time). Each participant completed the Neurobehavioral Symptom Inventory (NSI), which quantifies mTBI-related symptoms and provides a total score, as well as sub-scores on affective, cognitive, somatic, and vestibular domains.

Results: The mTBI group reported significantly higher symptom scores across each NSI sub-score (all Ps < .001). The mTBI group had a significantly larger sway area than the control group across all mCTSIB conditions and the mTBI group had significantly higher sensory reweighting scores compared to the control group on both the firm (P = .01) and foam (P = .04) surfaces. Within the mTBI group, the NSI vestibular score significantly related to the mCTSIB sway area EcFi (r = 0.38; P = .02), sway area EcFo (r = 0.43; P = .006), sensory reweighting firm (r = 0.33; P = .04), and sensory reweighting foam (r = 0.38; P = .02). The average sway area across the 4 mCTSIB conditions was significantly (area under the curve: 0.77; P < .001) better at differentiating groups than the mCTSIB clinical total score. The average sway area across the 4 mCTSIB conditions had a sensitivity of 73% and a specificity of 71%. The clinical mCTSIB outcome scores were not different between groups.

Conclusion: People with chronic mTBI appear to have central sensory integration deficits detectable by instrumented measures of postural assessment. These findings suggest that central sensory integration should be targeted in rehabilitation for people with chronic mTBI.

慢性轻度创伤性脑损伤(mTBI)患者的平衡缺陷;mtbi后≥3个月),被认为与中枢感觉统合缺陷有关,是微妙的,通常难以发现。本研究的目的是确定仪器改良的感觉统合平衡临床测试(mCTSIB)在有症状的慢性mTBI患者中识别这种平衡缺陷的敏感性,并在慢性mTBI组中建立平衡与mTBI症状评分之间的关联。方法:机构审查委员会批准了这些研究方法。41名慢性mTBI患者和53名健康对照者进行了mCTSIB(在坚硬/泡沫表面睁眼/闭眼;EoFi, EcFi, EoFo和EcFo),腰上有一个可穿戴传感器来量化摆动面积(m2/s4)。计算了坚固和泡沫姿态条件下的感官重加权变量。秒表提供mCTSIB(时间)的临床结果。每个参与者都完成了神经行为症状量表(NSI),该量表量化了mtbi相关症状,并提供了总分,以及情感、认知、躯体和前庭域的分值。结果mTBI组在NSI各子评分中均报告了更高的症状评分(均p < 0.001)。在所有mCTSIB条件下,mTBI组的摇摆面积明显大于对照组,mTBI组在坚固表面(P = 0.01)和泡沫表面(P = 0.04)上的感觉重加权得分明显高于对照组。在mTBI组中,NSI前庭评分与mCTSIB摇摆区EcFi显著相关(r = 0.38;P = 0.02),摇摆区EcFo (r = 0.43;P = 0.006),感觉重加权坚定(r = 0.33;P = 0.04),感觉重加权泡沫(r = 0.38;p = .02)。4种mCTSIB条件下的平均摇摆面积显著(曲线下面积:0.77;P < 0.001)优于mCTSIB临床总分。4种mCTSIB条件下的平均摇摆面积敏感性为73%,特异性为71%。临床mCTSIB结果评分组间无差异。结论慢性mTBI患者似乎有中枢感觉统合缺陷,可通过体位评估仪器检测到。这些发现表明中枢感觉统合应该成为慢性mTBI患者康复的目标。
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引用次数: 0
Physiological Demands and Characteristics of Movement During Simulated Combat. 模拟作战中的生理需求和运动特点。
Pub Date : 2023-11-03 DOI: 10.1093/milmed/usac163
Jonas Larsson, M Charlotte Olsson, Ann Bremander, Magnus Dencker

Introduction: Military tasks place considerable physiological demands on the soldier. It is therefore important to know the energy expenditure of soldiers while solving tasks in different environments. The purpose of this study was to describe the cardiorespiratory demands of certain movements and activities on ground combat soldiers during military field operations using body sensors and simulated combat.

Materials and methods: Movement characteristics and cardiorespiratory responses were assessed in 42 soldiers (three women) in the Swedish Army. The different posts assessed were commander, combat engineer, driver, and gunner. The military field exercises examined were urban operations and retrograde operations in rough terrain. Measurements included (1) body mass, (2) heart rate (HR) including maximal (HRmax), (3) velocity, (4) accelerations/decelerations, and (5) distance moved. Maximal aerobic capacity (V̇O2peak, mL·kg-1·min-1) was tested in a laboratory setting when wearing combat gear and body armor.

Results: There was a weak positive correlation (r = 0.41 and 0.28, both P < .05) between VO2peak and percentage of time over 40% and 50% of maximal aerobic capacity during simulated combat. No differences were found for the different posts in time spent over 40% or 50% of maximal aerobic capacity and 76% of their HRmax (P > .05). Wearing combat gear and additional load while solving tasks resulted in mean HR varying between 98 and 111 beats·min-1, corresponding with 50-57% of the soldiers HRmax. Studying all exercises, mean HR was 105 ± 11 beats min-1, 54 ± 5% of HRmax corresponding to light work intensity. Soldiers performed between 2.8 and 4.9 accelerations/min in the different exercises. A significant correlation between V̇O2peak (mL kg-1 min-1) and acceleration and m/min were found, implying that soldiers with good aerobic capacity were able to cope better with tasks requiring quick movements.

Conclusion: Conducting military operations in urban terrain and retrograde operations in rough terrain strains ground combat soldiers' cardiorespiratory system, with work intensities close to 40% of maximal aerobic capacity in 15-33% of mission time. Tasks with external load carriage include change of direction, accelerations, bounds, and jumping over obstacles, and physical fitness tests should replicate this. Findings in this study also add objective data to the physiological demands of work performed by combat soldiers while conducting urban operations and retrograde operations in rough terrain. These findings could be used to develop a model for classifying work demands for ground combat forces.

引言军事任务对士兵提出了相当高的生理要求。因此,了解士兵在不同环境中解决任务时的能量消耗是很重要的。本研究的目的是使用身体传感器和模拟战斗来描述地面作战士兵在军事野战中某些动作和活动的心肺需求。材料和方法对瑞典军队42名士兵(3名女性)的运动特征和心肺反应进行了评估。评估的不同职位包括指挥官、作战工程师、驾驶员和炮手。考察的军事实地演习是城市作战和在崎岖地形上的逆行作战。测量包括(1)体重,(2)心率(HR),包括最大心率(HRmax),(3)速度,(4)加速/减速,以及(5)移动距离。在实验室环境中测试了穿着战斗装备和防弹衣时的最大有氧能力(V̇O2peak,mL·kg-1·min-1)。结果两者呈弱正相关(r = 0.41和0.28,均为P  .05)。在解决任务时穿戴作战装备和额外负荷导致平均HR在98到111拍·min-1之间变化,对应于50-57%的士兵HRmax。研究所有练习,平均HR为105 ± 11次心跳min-1,54 ± 对应于光工作强度的HRmax的5%。在不同的演习中,士兵们的加速度在2.8到4.9之间/分钟。V̇O2峰值(mL kg-1 min-1)与加速度和m/min之间存在显著相关性,这意味着具有良好有氧能力的士兵能够更好地应对需要快速运动的任务。结论在城市地形下进行军事行动和在崎岖地形下进行逆行行动会使地面作战士兵的心肺系统紧张,在15-33%的任务时间内,工作强度接近最大有氧能力的40%。外部承载的任务包括改变方向、加速度、边界和跳过障碍物,体能测试应该重复这一点。这项研究的发现还为作战士兵在崎岖地形中进行城市作战和逆行作战时所需的生理需求增加了客观数据。这些发现可用于开发地面作战部队工作需求分类模型。
{"title":"Physiological Demands and Characteristics of Movement During Simulated Combat.","authors":"Jonas Larsson, M Charlotte Olsson, Ann Bremander, Magnus Dencker","doi":"10.1093/milmed/usac163","DOIUrl":"10.1093/milmed/usac163","url":null,"abstract":"<p><strong>Introduction: </strong>Military tasks place considerable physiological demands on the soldier. It is therefore important to know the energy expenditure of soldiers while solving tasks in different environments. The purpose of this study was to describe the cardiorespiratory demands of certain movements and activities on ground combat soldiers during military field operations using body sensors and simulated combat.</p><p><strong>Materials and methods: </strong>Movement characteristics and cardiorespiratory responses were assessed in 42 soldiers (three women) in the Swedish Army. The different posts assessed were commander, combat engineer, driver, and gunner. The military field exercises examined were urban operations and retrograde operations in rough terrain. Measurements included (1) body mass, (2) heart rate (HR) including maximal (HRmax), (3) velocity, (4) accelerations/decelerations, and (5) distance moved. Maximal aerobic capacity (V̇O2peak, mL·kg-1·min-1) was tested in a laboratory setting when wearing combat gear and body armor.</p><p><strong>Results: </strong>There was a weak positive correlation (r = 0.41 and 0.28, both P < .05) between VO2peak and percentage of time over 40% and 50% of maximal aerobic capacity during simulated combat. No differences were found for the different posts in time spent over 40% or 50% of maximal aerobic capacity and 76% of their HRmax (P > .05). Wearing combat gear and additional load while solving tasks resulted in mean HR varying between 98 and 111 beats·min-1, corresponding with 50-57% of the soldiers HRmax. Studying all exercises, mean HR was 105 ± 11 beats min-1, 54 ± 5% of HRmax corresponding to light work intensity. Soldiers performed between 2.8 and 4.9 accelerations/min in the different exercises. A significant correlation between V̇O2peak (mL kg-1 min-1) and acceleration and m/min were found, implying that soldiers with good aerobic capacity were able to cope better with tasks requiring quick movements.</p><p><strong>Conclusion: </strong>Conducting military operations in urban terrain and retrograde operations in rough terrain strains ground combat soldiers' cardiorespiratory system, with work intensities close to 40% of maximal aerobic capacity in 15-33% of mission time. Tasks with external load carriage include change of direction, accelerations, bounds, and jumping over obstacles, and physical fitness tests should replicate this. Findings in this study also add objective data to the physiological demands of work performed by combat soldiers while conducting urban operations and retrograde operations in rough terrain. These findings could be used to develop a model for classifying work demands for ground combat forces.</p>","PeriodicalId":86137,"journal":{"name":"Military surgeon","volume":" ","pages":"3496-3505"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49597540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Correlates of Dietary Behaviors Among Young Emirati Males Completing Compulsory Military Service. 完成义务兵役的阿联酋青年男性饮食行为的相关性。
Pub Date : 2023-11-03 DOI: 10.1093/milmed/usac150
Ahmad M Malkawi, Ree M Meertens, Stef P J Kremers, Ester F C van der Borgh-Sleddens, Gareth C Picknell, Mouza Al Shehhi

Introduction: It is important to understand the correlates of different dietary behaviors in a military context in the United Arab Emirates (UAE) to guide intervention development to prevent and treat obesity as it has a significant impact at the country and regional level. This study aimed to assess different dietary behaviors and their association with potential correlates including age, marital status, educational level, smoking status, screen time, dietary knowledge, eating self-efficacy, and general self-efficacy.

Materials and methods: The study used a cross-sectional design and included 153 (M = 25.9 years, SD = ± 3.2) military recruits completing their basic training at a single military camp in the UAE. Dietary behaviors of these recruits were measured using the Arab Teens Lifestyle Study. Other potential correlates included dietary knowledge, general self-efficacy, and eating efficacy. The ethical approval was obtained from the research ethics committee in the UAE university.

Results: Daily intake of fruits, vegetables, and breakfast was reported by 14.4%, 25.5%, and 22.9% of the military recruits, respectively. Almost half of the recruits (46.4%) consumed sugar-sweetened drinks more than 3 times a week, 39.2% consumed fast food more than 3 times a week, and 37.3% consumed sweets/chocolates more than 3 times a week. Bivariate regression analyses revealed that eating self-efficacy was positively associated with breakfast and dairy food consumption, although it was inversely associated with sugar, fast-food, and French fries intake. Age was significantly and inversely associated with sugar, fast-food, and energy drink intake. Moreover, nutrition knowledge was significantly and positively correlated with vegetable intake and negatively correlated with energy drink consumption. Multiple regressions showed that lower age and lower eating self-efficacy were found to be the main predictors for sugar-sweetened drinks (adjusted R2 = 0.112) and fast-food intake (adjusted R2 = 0.084). Also, a higher dietary knowledge score was a predictor of vegetable intake (adjusted R2 = 0.093), although age and smoking predict energy drink intake (adjusted R2 = 0.225).

Conclusions: The results show that unhealthy eating patterns are common among new recruits in the UAE military. The study suggests that age, eating self-efficacy, and nutrition knowledge are the main correlates of selected dietary behaviors. Interventions are advised to target these correlates to achieve healthier dietary habits inside the military.

在阿拉伯联合酋长国(UAE)的军事背景下,了解不同饮食行为的相关性对于指导干预发展以预防和治疗肥胖具有重要意义,因为它在国家和地区层面具有重大影响。本研究旨在评估不同的饮食行为及其与潜在相关因素的关系,包括年龄、婚姻状况、教育程度、吸烟状况、屏幕时间、饮食知识、饮食自我效能感和一般自我效能感。材料与方法本研究采用横断面设计,纳入153名(M = 25.9岁,SD =±3.2)在阿联酋单一军营完成基础训练的新兵。这些新兵的饮食行为是通过阿拉伯青少年生活方式研究来测量的。其他潜在的相关因素包括饮食知识、一般自我效能和饮食效能。获得了阿联酋大学研究伦理委员会的伦理批准。结果新兵每天水果、蔬菜和早餐的摄入量分别为14.4%、25.5%和22.9%。近一半(46.4%)的受访者每周饮用含糖饮料超过3次,39.2%的受访者每周食用快餐超过3次,37.3%的受访者每周食用糖果/巧克力超过3次。双变量回归分析显示,饮食自我效能感与早餐和乳制品的摄入量呈正相关,尽管它与糖、快餐和炸薯条的摄入量呈负相关。年龄与糖、快餐和能量饮料的摄入量呈显著负相关。营养知识与蔬菜摄入量呈显著正相关,与能量饮料消费量呈显著负相关。多元回归结果显示,低年龄和低饮食自我效能是含糖饮料(调整R2 = 0.112)和快餐摄入(调整R2 = 0.084)的主要预测因子。此外,较高的饮食知识分数是蔬菜摄入量的预测因子(调整后的R2 = 0.093),尽管年龄和吸烟预测能量饮料摄入量(调整后的R2 = 0.225)。结论阿联酋军队新兵普遍存在不健康的饮食习惯。研究表明,年龄、饮食自我效能和营养知识是选择饮食行为的主要相关因素。建议针对这些相关因素采取干预措施,以在军队内部实现更健康的饮食习惯。
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引用次数: 0
Health Conditions Among Navy Submariners at the End of Active Duty; A Retrospective Cohort Study. 美国海军退役潜艇艇员健康状况研究回顾性队列研究。
Pub Date : 2023-07-22 Epub Date: 2022-03-12 DOI: 10.1093/milmed/usac063
Brian J Maguire, Linda M Hughes, Douglas C McAdams, Michael Gilbert, Robert Nordness
<p><strong>Introduction: </strong>Maintaining healthy, well-trained, and highly qualified armed forces is critical for ensuring military readiness. The purpose of this article is to contribute to the body of research focused on the health of U.S. Navy submariners and to identify the health conditions of U.S. Navy submariners during their final year of active duty service.</p><p><strong>Materials and methods: </strong>In this retrospective cohort study, we examined medical records and personnel files of separating U.S. Navy sailors who were: (1) active duty between 2009 and 2018; (2) separated before 2019; and (3) were assigned to a submarine for at least 30 days. Both officers and enlisted service members were included. We linked, described, and analyzed data from the Defense Health Agency, Military Health System Data Repository (MDR), and the Bureau of Naval Personnel (BUPERS). International Classification of Diseases (ICD) diagnoses codes were obtained from MDR. Data collected from BUPERS include age, sex, and rank. We determined the number of individuals who had at least one diagnosed condition (identified as a three-digit ICD code). We report the number of diagnoses and calculate prevalence rates and confidence intervals per condition, as well as prevalence rates per year, using standard formulas. The study was approved by the Naval Submarine Medical Research Laboratory Institutional Review Board.</p><p><strong>Results: </strong>During the study period, 26,014 submariners separated from the Navy. The average number of separations per year was 2,601. About a third of the separating submariners were in the 25 to 29 age group and over 50% were under 30 years of age. Of the three-digit individual ICD codes, some of the highest operationally relevant rates over the 10-year study period (2009-2018) were for joint disorders (prevalence rate [PR] = 180 per 1,000 submariners), back disorders (PR = 128), and sleep disorders (PR = 134). Three mental-health-related conditions were also among the 20 conditions with the highest rates.</p><p><strong>Conclusions: </strong>High rates of specific diagnoses such as joint disorders indicate the need for additional study to examine causal relationships, to determine which conditions may contribute to lost work time, early separations, or low rates of reenlistment and which conditions might be a result of specific military occupations or duties. Study strengths are the large number of subjects and the long period of observations. A study weakness was the inability to identify submariners who separated because of health conditions. The overall impact of the study is that it identifies urgent health risks and establishes a way to prioritize future research. Future research should include a focus on medically separated personnel; compare rates for submariners to other military groups including all-Navy and all-Department of Defense; and determine specific and relative risks as a necessary precursor to developing, imp
保持健康、训练有素和高素质的武装部队是确保军事准备的关键。这篇文章的目的是为美国海军潜艇艇员健康的研究机构做出贡献,并确定美国海军潜艇艇员在现役服务的最后一年的健康状况。材料与方法在这项回顾性队列研究中,我们检查了美国海军退役水手的医疗记录和人事档案,他们:(1)2009年至2018年现役;(2) 2019年前分居;(3)被分配到潜艇上至少30天。军官和士兵都包括在内。我们链接、描述并分析了来自国防卫生机构、军事卫生系统数据存储库(MDR)和海军人事局(BUPERS)的数据。国际疾病分类(ICD)诊断代码由多药耐药获得。从BUPERS收集的数据包括年龄、性别和级别。我们确定了至少有一种诊断病症(以三位数ICD代码标识)的个体数量。我们使用标准公式报告诊断的数量,并计算每种疾病的患病率和置信区间,以及每年的患病率。这项研究得到了海军潜艇医学研究实验室机构审查委员会的批准。结果在研究期间,26,014名潜艇兵脱离了海军。每年平均离职人数为2 601人。大约三分之一的分离潜艇艇员年龄在25至29岁之间,超过50%的艇员年龄在30岁以下。在三位数的个体ICD代码中,在10年研究期间(2009-2018年),与操作相关的最高发病率是关节疾病(患病率[PR] = 180 / 1000)、背部疾病(患病率= 128)和睡眠障碍(患病率= 134)。在20种疾病中,三种与精神健康相关的疾病也是发病率最高的。结论:关节疾病等特殊诊断的高比例表明需要进一步研究因果关系,以确定哪些情况可能导致失去工作时间、提前离职或低重新入伍率,哪些情况可能是特定军事职业或职责的结果。研究的优势在于研究对象多,观察时间长。研究的一个弱点是无法确定因健康状况而分离的潜艇兵。这项研究的总体影响是,它确定了紧急的健康风险,并确定了优先考虑未来研究的方法。未来的研究应包括对医学隔离人员的关注;将潜艇的费率与其他军事团体进行比较,包括全海军和全国防部;确定具体的和相对的风险,作为制定、实施和测试降低风险和改善健康干预措施的必要先导。
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引用次数: 0
Evaluation of an Injectable, Solid-State, Oxygen-Delivering Compound (Ox66) in a Rodent Model of Pulmonary Dysfunction-Induced Hypoxia. 一种可注射的固态给氧化合物(Ox66)在肺功能障碍诱导的缺氧啮齿动物模型中的评价。
Pub Date : 2023-07-22 Epub Date: 2022-03-12 DOI: 10.1093/milmed/usac059
Danuel A Carr, William H Nugent, Erica D Bruce, Bjorn K Song

Introduction: Pulmonary dysfunction (PD) and its associated hypoxia present a complication to the care of many service members and can arise intrinsically via comorbidities or extrinsically by infection or combat-related trauma (burn, smoke inhalation, and traumatic acute lung injury). Current supportive treatments (e.g., ventilation and supplemental oxygen) relieve hypoxia but carry a significant risk of further lung injury that drives mortality. Ox66 is a novel, solid-state oxygenating compound capable of delivering oxygen via intravenous infusion.

Materials and methods: Male Sprague Dawley rats (N = 21; 250-300 g) were surgically prepared for cardiovascular monitoring, fluid infusion, mechanical ventilation, and intravital and phosphorescence quenching microscopy (interstitial oxygen tension; PISFO2) of the spinotrapezius muscle. Baselines (BL) were collected under anesthesia and spontaneous respiration. PD was simulated via hypoventilation (50% tidal volume reduction) and was maintained for 3 hours. Groups were randomized to receive Ox66, normal saline (NS; vehicle control), or Sham (no treatment) and were treated immediately following PD onset. Arterial blood samples (65 µL) and intravital images were taken hourly to assess blood gases and chemistry and changes in arteriolar diameter, respectively. Significance was taken at P < .05.

Results: PD reduced PISFO2 for all groups; however, by 75 minutes, both NS and Sham were significantly lower than Ox66 and remained so until the end of PD. Serum lactate levels were lowest in the Ox66 group-even decreasing relative to BL-but only significant versus Sham. Furthermore, all Ox66 animals survived the full PD challenge, while one NS and two Sham animals died. No significant vasoconstrictive or vasodilative effect was noted within or between experimental groups.

Conclusion: Treatment with intravenous Ox66 improved interstitial oxygenation in the spinotrapezius muscle-a recognized bellwether for systemic capillary function-suggesting an improvement in oxygen delivery. Ox66 offers a novel approach to supplemental oxygenation that bypasses lung injury and dysfunction.

肺功能障碍(PD)及其相关的缺氧是许多服役人员的一个并发症,它可以通过内在的合并症或外部的感染或与战斗有关的创伤(烧伤、烟雾吸入和创伤性急性肺损伤)引起。目前的支持治疗(例如,通气和补充氧气)缓解了缺氧,但存在进一步肺损伤的显著风险,从而导致死亡。Ox66是一种新型的固体加氧化合物,能够通过静脉输注输送氧气。材料与方法Sprague Dawley大鼠(N = 21;250-300 g)手术准备,用于心血管监测、输液、机械通气、生命和磷光猝灭显微镜(间质氧张力;脊柱斜方肌的PISFO2)。在麻醉和自主呼吸下采集基线(BL)。通过低通气(潮气量减少50%)模拟PD,并维持3小时。各组随机接受Ox66、生理盐水(NS;对照组)或假手术组(不治疗),并在PD发作后立即治疗。每小时采集动脉血样本(65µL)和活体图像,分别评估血气和化学以及小动脉直径的变化。P < 0.05为显著性。结果spd降低各组PISFO2;然而,到75分钟时,NS和Sham均明显低于Ox66,并一直保持到PD结束。Ox66组血清乳酸水平最低,甚至比bl组降低,但仅与Sham组比较有显著性。此外,所有Ox66动物都存活了完全PD挑战,而1只NS和2只Sham动物死亡。在实验组内或实验组之间没有发现明显的血管收缩或血管扩张作用。结论静脉注射Ox66改善了斜方棘肌间质氧合,这是公认的全身毛细血管功能的风向标,表明氧输送改善。Ox66提供了一种新的方法来补充氧合,绕过肺损伤和功能障碍。
{"title":"Evaluation of an Injectable, Solid-State, Oxygen-Delivering Compound (Ox66) in a Rodent Model of Pulmonary Dysfunction-Induced Hypoxia.","authors":"Danuel A Carr, William H Nugent, Erica D Bruce, Bjorn K Song","doi":"10.1093/milmed/usac059","DOIUrl":"10.1093/milmed/usac059","url":null,"abstract":"<p><strong>Introduction: </strong>Pulmonary dysfunction (PD) and its associated hypoxia present a complication to the care of many service members and can arise intrinsically via comorbidities or extrinsically by infection or combat-related trauma (burn, smoke inhalation, and traumatic acute lung injury). Current supportive treatments (e.g., ventilation and supplemental oxygen) relieve hypoxia but carry a significant risk of further lung injury that drives mortality. Ox66 is a novel, solid-state oxygenating compound capable of delivering oxygen via intravenous infusion.</p><p><strong>Materials and methods: </strong>Male Sprague Dawley rats (N = 21; 250-300 g) were surgically prepared for cardiovascular monitoring, fluid infusion, mechanical ventilation, and intravital and phosphorescence quenching microscopy (interstitial oxygen tension; PISFO2) of the spinotrapezius muscle. Baselines (BL) were collected under anesthesia and spontaneous respiration. PD was simulated via hypoventilation (50% tidal volume reduction) and was maintained for 3 hours. Groups were randomized to receive Ox66, normal saline (NS; vehicle control), or Sham (no treatment) and were treated immediately following PD onset. Arterial blood samples (65 µL) and intravital images were taken hourly to assess blood gases and chemistry and changes in arteriolar diameter, respectively. Significance was taken at P < .05.</p><p><strong>Results: </strong>PD reduced PISFO2 for all groups; however, by 75 minutes, both NS and Sham were significantly lower than Ox66 and remained so until the end of PD. Serum lactate levels were lowest in the Ox66 group-even decreasing relative to BL-but only significant versus Sham. Furthermore, all Ox66 animals survived the full PD challenge, while one NS and two Sham animals died. No significant vasoconstrictive or vasodilative effect was noted within or between experimental groups.</p><p><strong>Conclusion: </strong>Treatment with intravenous Ox66 improved interstitial oxygenation in the spinotrapezius muscle-a recognized bellwether for systemic capillary function-suggesting an improvement in oxygen delivery. Ox66 offers a novel approach to supplemental oxygenation that bypasses lung injury and dysfunction.</p>","PeriodicalId":86137,"journal":{"name":"Military surgeon","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47903396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep Deprivation and Self-Harm Associated With Excessive Gaming: A Case Report. 睡眠剥夺与过度游戏相关的自我伤害:一个案例报告。
Pub Date : 2023-07-22 Epub Date: 2022-04-26 DOI: 10.1093/milmed/usac116
Amanda M Hall, Stuart D Glass, William A McDonald, Nathaniel B Almond, Andrew P Doan

Excessive gaming may be associated with sleep deprivation and self-harm. One active duty member committed self-injurious behavior to avoid work-related consequences. It was discovered that the patient participated in a video-gaming binge throughout an entire 72-hour weekend liberty. The patient experienced severe sleep deprivation to the point where he overslept and failed to report to work. He injured himself and fabricated a robbery and assault to avoid disciplinary consequences. Military health care providers should consider excessive gaming in patients presenting with sleep issues, self-harm, and disciplinary problems. As the prevalence of gaming increases, the military leadership should be aware that excessive gaming can degrade force readiness.

过度的游戏可能与睡眠不足和自残有关。一名现役军人为避免与工作有关的后果而做出自残行为。研究发现,该患者在整个72小时的周末自由活动中都参与了一场电子游戏狂欢。患者经历了严重的睡眠不足,以至于睡过头,没有上班。他打伤了自己,并编造了抢劫和袭击事件,以避免受到纪律处分。军事医疗保健提供者应考虑对出现睡眠问题、自残和纪律问题的患者进行过度游戏。随着游戏的普及,军事领导层应该意识到,过度的游戏会降低部队的战备状态。
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引用次数: 0
Remote Damage Control Resuscitation: A Case Report of Hemorrhagic Shock Secondary to Multiple Gunshot Wounds. 远程损伤控制复苏:多发枪伤致失血性休克1例报告。
Pub Date : 2023-07-22 Epub Date: 2022-05-26 DOI: 10.1093/milmed/usac139
Gal Puris, Shaul Gelikas, Regina Pikman, Shachar Shapira, Tomer Talmy, Ofer Almog, Mark H Yazer, Avi Benov, Sami Gendler

Hypovolemic shock is the leading cause of preventable death on the battlefield. Remote damage control resuscitation has evolved dramatically in the past decade by introducing novel treatments and approaches to bleeding in the prehospital setting. This report presents a case of a casualty who sustained multiple gunshot wounds to the chest and gluteal regions and suffered from hemorrhagic shock with an Injury Severity Score of 34. The casualty was treated at the point of injury and during evacuation according to the IDF's remote damage control resuscitation algorithm utilizing the range of blood products available in the IDF. Prompt identification of the mechanism of injury, clinical and tactical decision-making, and immediate advanced medical care through several prehospital medical evacuation platforms culminated in this casualty's survival. This case emphasizes the importance of medical advancements in prehospital field care and guideline-directed treatment to improve casualty survival.

低血容量性休克是战场上可预防死亡的主要原因。在过去的十年里,通过在院前环境中引入新的出血治疗方法和方法,远程损伤控制复苏术发生了巨大的变化。本报告介绍了一例胸部和臀大区多处枪伤的伤员,并患有失血性休克,损伤严重程度评分为34。根据以色列国防军的远程损伤控制复苏算法,利用以色列国防军可用的一系列血液制品,在受伤点和疏散期间对伤员进行了治疗。通过几个院前医疗疏散平台,及时识别受伤机制,做出临床和战术决策,并立即进行高级医疗护理,最终使这名伤员得以幸存。该病例强调了医疗进步在院前现场护理和指导治疗方面的重要性,以提高伤员的生存率。
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引用次数: 0
A Review of GnRH Antagonists as Treatment for Abnormal Uterine Bleeding-Leiomyoma (AUB-L) and Their Influence on the Readiness of Service Members. GnRH拮抗剂治疗子宫异常出血-平滑肌瘤(AUB-L)及其对军人备战状态的影响
Pub Date : 2023-07-22 Epub Date: 2022-03-28 DOI: 10.1093/milmed/usac078
Danielle Wright, Ji Won Kim, Halle Lindsay, William H Catherino

Introduction: Not too long ago, Lupron Depot® (leuprolide acetate), an injectable gonadotropin-releasing hormone (GnRH) agonist, was the only Food and Drug Administration (FDA) approved GnRH analog used to clinically treat abnormal uterine bleeding associated with uterine leiomyoma (AUB-L) when second-line medical management was warranted; however, the FDA has now approved elagolix and relugolix, GnRH antagonists, to be treatment options as well. This is a review of GnRH antagonists for the management of uterine fibroids reviewing their treatment efficacy, side effect profile, and current use in military medicine.

Methods: This is a review of studies from multiple electronic databases (Pubmed, ACOG, FDA, U.S. Military Guidelines) published between 1990 and 2021. Keywords used for the search include GnRH antagonist, elagolix, relugolix, uterine leiomyoma, and abnormal uterine bleeding. Our inclusion criteria for articles reviewed were: systematic reviews with the listed keywords, multicenter randomized trials, and meta-analyses. The DODI on Medical Standards for Medical Service, Air Force Aerospace Medicine Waiver Guide, Navy Guidance Aeromedical Reference and Waiver Guide, and the Army Regulation 40-501 Standards of Medical Fitness were used to review the military standards and current restrictions placed on service members.

Results: Thirty-three articles were reviewed and summarized.

Conclusion: Uterine leiomyoma can impact service members' eligibility and fitness for duty. The oral administration of elagolix and relugolix adds convenience to this drug class through its oral administration while lengthening the duration of treatment up to 24 months. All military medical facilities should advocate for the well-being of their service members by stocking all options available. Health care providers should collaborate with patients in making the best therapy choice that is suited for their lifestyle and military occupation.

不久前,一种可注射的促性腺激素释放激素(GnRH)激动剂Lupron Depot®(醋酸leuprolide acetate)是美国食品和药物管理局(FDA)唯一批准用于临床治疗子宫平滑肌瘤(AUB-L)相关异常子宫出血的GnRH类似物。然而,FDA现在已经批准了GnRH拮抗剂elagolix和relugolix作为治疗选择。这是一篇关于GnRH拮抗剂治疗子宫肌瘤的综述,综述了它们的治疗效果、副作用和目前在军事医学中的应用。方法:这是对1990年至2021年间发表的多个电子数据库(Pubmed, ACOG, FDA, U.S. Military Guidelines)研究的综述。搜索的关键词包括GnRH拮抗剂、elagolix、relugolix、子宫平滑肌瘤、子宫异常出血。我们对文章的纳入标准是:列出关键词的系统评价、多中心随机试验和荟萃分析。根据《医疗服务医疗标准DODI》、《空军航空航天医学豁免指南》、《海军航空医学指南和豁免指南》、《陆军条例40-501医疗健康标准》,对军队标准和现役人员的现行限制进行了审查。结果对33篇文献进行了综述。结论子宫平滑肌瘤会影响现役军人的服役资格和健康。口服elagolix和relugolix通过口服给药增加了这类药物的便利性,同时延长了治疗时间,最长可达24个月。所有军事医疗设施都应通过储存所有可用的选择来倡导其服务人员的福祉。卫生保健提供者应与患者合作,做出适合其生活方式和军事职业的最佳治疗选择。
{"title":"A Review of GnRH Antagonists as Treatment for Abnormal Uterine Bleeding-Leiomyoma (AUB-L) and Their Influence on the Readiness of Service Members.","authors":"Danielle Wright, Ji Won Kim, Halle Lindsay, William H Catherino","doi":"10.1093/milmed/usac078","DOIUrl":"10.1093/milmed/usac078","url":null,"abstract":"<p><strong>Introduction: </strong>Not too long ago, Lupron Depot® (leuprolide acetate), an injectable gonadotropin-releasing hormone (GnRH) agonist, was the only Food and Drug Administration (FDA) approved GnRH analog used to clinically treat abnormal uterine bleeding associated with uterine leiomyoma (AUB-L) when second-line medical management was warranted; however, the FDA has now approved elagolix and relugolix, GnRH antagonists, to be treatment options as well. This is a review of GnRH antagonists for the management of uterine fibroids reviewing their treatment efficacy, side effect profile, and current use in military medicine.</p><p><strong>Methods: </strong>This is a review of studies from multiple electronic databases (Pubmed, ACOG, FDA, U.S. Military Guidelines) published between 1990 and 2021. Keywords used for the search include GnRH antagonist, elagolix, relugolix, uterine leiomyoma, and abnormal uterine bleeding. Our inclusion criteria for articles reviewed were: systematic reviews with the listed keywords, multicenter randomized trials, and meta-analyses. The DODI on Medical Standards for Medical Service, Air Force Aerospace Medicine Waiver Guide, Navy Guidance Aeromedical Reference and Waiver Guide, and the Army Regulation 40-501 Standards of Medical Fitness were used to review the military standards and current restrictions placed on service members.</p><p><strong>Results: </strong>Thirty-three articles were reviewed and summarized.</p><p><strong>Conclusion: </strong>Uterine leiomyoma can impact service members' eligibility and fitness for duty. The oral administration of elagolix and relugolix adds convenience to this drug class through its oral administration while lengthening the duration of treatment up to 24 months. All military medical facilities should advocate for the well-being of their service members by stocking all options available. Health care providers should collaborate with patients in making the best therapy choice that is suited for their lifestyle and military occupation.</p>","PeriodicalId":86137,"journal":{"name":"Military surgeon","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46002155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Military surgeon
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