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Leadership Lessons From the Field: Leading Others to Cope With Death. 《战地领导经验:带领他人面对死亡》
Pub Date : 2022-05-20 DOI: 10.1093/milmed/usac128
Jamie Geringer, S. Durning
All healthcare leaders will inevitably face patient death and dealing with loss. While leaders have different preparation for this, many lack comfort and confidence navigating death, whether it be of a patient, family member, or colleague. Learning how to support others in dealing with death is a fundamental leadership skill.
所有医疗保健领导者都将不可避免地面临患者死亡和损失。尽管领导人对此有不同的准备,但许多人在死亡中缺乏安慰和信心,无论是患者、家人还是同事。学习如何支持他人应对死亡是一项基本的领导技能。
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引用次数: 0
A Survey Among Cadets at the United States Military Academy on Knowledge and Wearing of Permethrin-Treated Uniforms and the Risk of Tick-Borne Diseases. 美国军事学院学员对氯菊酯处理制服的了解和穿着以及蜱传疾病风险的调查。
Pub Date : 2022-05-19 DOI: 10.1093/milmed/usac131
Alyssa H Chellaraj, Dylan J Nun, Jason Y Johnson, Kiley A Sweet, Alex M Burgess, Galina M Gordon, Skyler A Chauff, Benjamin M Millican, Canden J Wilkinson, Silas A Davidson

Introduction: The Army uses permethrin-treated uniforms as the primary method to protect soldiers from tick-borne diseases. Permethrin binds strongly to fabric and provides long-term protection against many blood-feeding arthropods. However, protection decreases if the uniforms are not washed and cared for according to label instructions. This study was conducted among cadets at the United States Military Academy (USMA) at West Point, NY, to determine what the cadets know about permethrin and how they care for and wear their uniforms. West Point is in an area with high rates of tick-borne disease transmission. A survey was developed to determine what cadets know about the threat of tick-borne diseases and if they wear and maintain their uniforms in a manner that effectively maintains permethrin levels.

Materials and methods: A 16-question survey was developed and submitted to the local review board for approval. The study was classified as human subjects research according to 32CFR219 and met the requirements for exempt status under 32CFR219.104(d)(2)(i). After receiving approval, a hard copy survey was distributed among cadets with efforts to sample at least 50 members from each cadet class.

Results: A total of 319 cadets provided responses to the survey questions, representing more than 7% of the cadet population at the USMA. The results showed most cadets knew their uniforms were treated with permethrin, but less than half knew there are specific instructions attached to their uniforms describing how the uniforms should be laundered. From the cadets who knew there were instructions, most admittedly did not follow the instructions. Sixteen percent of cadets said they had dry-cleaned their uniforms. This is a process known to remove most of the permethrin. The majority of cadets viewed the risk of tick-borne disease at West Point to be moderate or lower.

Conclusions: This study provides a basic understanding of the wear patterns of permethrin-treated uniforms among cadets at the USMA. It is also one of the few studies to measure knowledge and uniform-wearing behavior among service members since the Army switched to factory-treated uniforms in 2013. The results indicate that compliance with uniform laundry and care instructions is low. This information is useful to develop training plans and educate cadets how they can wear and take care of their permethrin-treated uniforms to better protect themselves from tick-borne diseases.

陆军使用氯菊酯处理的制服作为保护士兵免受蜱传疾病的主要方法。氯菊酯能与织物紧密结合,并对许多吸血节肢动物提供长期保护。然而,如果不按照标签上的说明清洗和保养制服,保护作用就会降低。这项研究是在纽约州西点军校的美国军事学院(USMA)的学员中进行的,目的是确定学员对氯菊酯的了解程度以及他们如何爱护和穿着制服。西点军校是一个蜱传疾病传播率很高的地区。开展了一项调查,以确定学员对蜱传疾病的威胁了解多少,以及他们是否以有效保持氯菊酯水平的方式穿着和保持制服。材料与方法一份包含16个问题的调查报告已提交当地审查委员会批准。根据32CFR219,该研究被归类为人类受试者研究,并符合32CFR219.104(d)(2)(i)的豁免状态要求。在获得批准后,在学员中分发了一份纸质调查问卷,力求从每个学员班中抽取至少50名成员。结果共有319名学员回答了调查问题,占USMA学员总数的7%以上。结果显示,大多数学员知道他们的制服被用氯菊酯处理过,但只有不到一半的学员知道制服上附有具体说明,说明如何清洗制服。从那些知道有指示的学员中,大多数人都承认没有遵守指示。16%的学员说他们干洗过制服。这是一种已知可以去除大部分氯菊酯的方法。大多数学员认为在西点军校感染蜱传疾病的风险是中等或较低的。结论本研究对美国海军陆战队军校学员使用氯菊酯处理过的制服的磨损规律有了初步的了解。这也是自2013年陆军改用工厂处理过的制服以来,为数不多的几项衡量军人知识和穿着制服行为的研究之一。结果表明,对统一洗衣和护理指导的遵守程度较低。这些信息有助于制定培训计划,并教育学员如何穿着和爱护经氯菊酯处理的制服,以更好地保护自己免受蜱虫传播疾病的侵害。
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引用次数: 0
Implementing Just Culture to Improve Patient Safety. 实施公正文化提高患者安全。
Pub Date : 2022-05-18 DOI: 10.1093/milmed/usac115
John S Murray, Joan Clifford, Stacey Larson, Jonathan K Lee, Gary L Sculli

Introduction: The number of deaths in the United States related to medical errors remains unacceptably high. Further complicating this situation is the problem of underreporting due to the fear of the consequences. In fact, the most commonly reported cause of underreporting worldwide is the fear of the negative consequences associated with reporting. As health care organizations along the journey to high-reliability strive to improve patient safety, a concerted effort needs to be focused on changing how medical errors are addressed. A paradigm shift is needed from immediately assigning blame and punishing individuals to one that is trusting and just. Staff must trust that when errors occur, organizations will respond in a manner that is fair and appropriate.

Materials and methods: An extensive review of the literature from 2017 until January 2022 was conducted for the most current evidence describing the principles and practices of "just culture" in health care organizations. Additionally, recommendations were sought on how health care organizations can go about implementing "just culture" principles.

Results: Twenty sources of evidence on "just culture' were retrieved and reviewed. The evidence was used to describe the concept and principles of "just culture" in health care organizations. Furthermore, five strategies for implementing "just culture" principles were identified.

Conclusions: Improving patient safety requires that high-reliability organizations strive to ensure that the culture of the organization is trusting and just. In a trusting and just culture, adverse events are recognized as valuable opportunities to understand contributing factors and learn rather than immediately assign blame. Moving away from a blame culture is a paradigm shift for many health care organizations yet critically important for improving patient safety.

在美国,与医疗事故相关的死亡人数仍然高得令人无法接受。由于担心后果而少报的问题使情况进一步复杂化。事实上,世界范围内报告少报的最常见原因是害怕与报告相关的负面后果。随着医疗保健组织在实现高可靠性的过程中努力提高患者安全性,需要共同努力,改变医疗错误的处理方式。我们需要一种模式的转变,从立即指责和惩罚个人到信任和公正。员工必须相信,当错误发生时,组织将以公平和适当的方式作出反应。材料和方法对2017年至2022年1月的文献进行了广泛的回顾,以获取描述医疗保健组织中“公正文化”原则和实践的最新证据。此外,还就卫生保健组织如何着手实施"公正文化"原则征求了建议。结果对“公正培养”的20个证据来源进行了检索和审查。这些证据被用来描述卫生保健组织中“公正文化”的概念和原则。此外,还确定了执行“公正文化”原则的五项战略。结论提高患者安全需要高可靠性组织努力确保组织文化是信任和公正的。在信任和公正的文化中,不良事件被认为是了解促成因素和学习的宝贵机会,而不是立即推卸责任。对许多医疗保健组织来说,摆脱指责文化是一种范式转变,但对提高患者安全至关重要。
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引用次数: 0
Combat-Related Invasive Fungal Wound Infections. 战斗相关的侵袭性真菌伤口感染。
Pub Date : 2022-05-01 DOI: 10.1093/milmed/usab074
Ret Carlos J Rodriguez, A. Ganesan, Faraz Shaikh, M. L. Carson, William P. Bradley, T. Warkentien, D. Tribble
INTRODUCTIONDuring Operation Enduring Freedom in Afghanistan, an outbreak of combat-related invasive fungal wound infections (IFIs) emerged among casualties with dismounted blast trauma and became a priority issue for the Military Health System.METHODSIn 2011, the Trauma Infectious Disease Outcomes Study (TIDOS) team led the Department of Defense IFI outbreak investigation to describe characteristics of IFIs among combat casualties and provide recommendations related to management of the disease. To support the outbreak investigation, existing IFI definitions and classifications utilized for immunocompromised patients were modified for use in epidemiologic research in a trauma population. Following the conclusion of the outbreak investigation, multiple retrospective analyses using a population of 77 IFI patients (injured during June 2009 to August 2011) were conducted to evaluate IFI epidemiology, wound microbiology, and diagnostics to support refinement of Joint Trauma System (JTS) clinical practice guidelines. Following cessation of combat operations in Afghanistan, the TIDOS database was comprehensively reviewed to identify patients with laboratory evidence of a fungal infection and refine the IFI classification scheme to incorporate timing of laboratory fungal evidence and include categories that denote a high or low level of suspicion for IFI. The refined IFI classification scheme was utilized in a large-scale epidemiologic assessment of casualties injured over a 5.5-year period.RESULTSAmong 720 combat casualties admitted to participating hospitals (2009-2014) who had histopathology and/or wound cultures collected, 94 (13%) met criteria for an IFI and 61 (8%) were classified as high suspicion of IFI. Risk factors for development of combat-related IFIs include sustaining a dismounted blast injury, experiencing a traumatic transfemoral amputation, and requiring resuscitation with large-volume (>20 units) blood transfusions. Moreover, TIDOS analyses demonstrated the adverse impact of IFIs on wound healing, particularly with order Mucorales. A polymerase chain reaction (PCR)-based assay to identify filamentous fungi and support earlier IFI diagnosis was also assessed using archived formalin-fixed, paraffin-embedded tissue specimens. Although the PCR-based assay had high specificity (99%), there was low sensitivity (63%); however, sensitivity improved to 83% in tissues collected from sites with angioinvasion. Data obtained from the initial IFI outbreak investigation (37 IFI patients) and subsequent TIDOS analyses (77 IFI patients) supported development and refinement of a JTS clinical practice guideline for the management of IFIs in war wounds. Furthermore, a local clinical practice guideline to screen for early tissue-based evidence of IFIs among blast casualties at the Landstuhl Regional Medical Center was critically evaluated through a TIDOS investigation, providing additional clinical practice support. Through a collaboration with th
在阿富汗持久自由行动期间,战斗相关的侵袭性真菌伤口感染(IFIs)在下车的爆炸创伤伤员中爆发,成为军队卫生系统的优先问题。方法2011年,创伤传染病结局研究(TIDOS)小组领导了国防部IFI爆发调查,以描述战斗伤亡中IFI的特征,并提供与疾病管理相关的建议。为了支持疫情调查,修改了用于免疫功能低下患者的现有IFI定义和分类,以便用于创伤人群的流行病学研究。在疫情调查结束后,对77名IFI患者(2009年6月至2011年8月期间受伤)进行了多次回顾性分析,以评估IFI流行病学、伤口微生物学和诊断,以支持改进关节创伤系统(JTS)临床实践指南。在阿富汗战斗行动结束后,对TIDOS数据库进行了全面审查,以确定具有真菌感染实验室证据的患者,并完善IFI分类方案,以纳入实验室真菌证据的时间,并包括表明IFI高或低怀疑程度的类别。精细化的IFI分类方案被用于5.5年期间伤亡的大规模流行病学评估。结果在2009-2014年参与医院接收的720名战斗伤病员中,收集了组织病理学和/或伤口培养物,94名(13%)符合IFI标准,61名(8%)被归类为高度怀疑IFI。发生与战斗有关的ifi的危险因素包括:遭受下车的爆炸伤害、经历外伤性经股截肢,以及需要大容量(100 - 20单位)输血进行复苏。此外,TIDOS分析显示ifi对伤口愈合的不利影响,特别是对毛霉菌。利用存档的福尔马林固定石蜡包埋组织标本,对基于聚合酶链反应(PCR)的鉴定丝状真菌和支持早期IFI诊断的方法进行了评估。尽管基于pcr的检测具有高特异性(99%),但灵敏度较低(63%);然而,在血管浸润部位收集的组织中,敏感性提高到83%。从最初的IFI暴发调查(37例IFI患者)和随后的TIDOS分析(77例IFI患者)中获得的数据支持了JTS关于战争创伤IFI管理的临床实践指南的制定和完善。此外,通过一项TIDOS调查,对Landstuhl地区医疗中心在爆炸伤员中筛查ifi早期组织证据的当地临床实践指南进行了严格评估,提供了额外的临床实践支持。通过与统一服务大学外科重症监护倡议的合作,TIDOS分析的结果被用于支持临床决策支持工具的开发,以促进早期风险分层。结论与战斗相关的ifi是严重爆炸创伤后的一种高发病率并发症,仍然是未来现代战争的威胁。我们的研究结果支持了JTS的临床建议,完善了IFI分类,并证实了基于pcr的检测方法作为组织病理学和/或培养的补充,可以促进早期诊断。正在进行或计划进行的分析将增加国际金融机构流行病学、诊断、预防和管理的知识库。
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引用次数: 8
Department of Defense Trauma Registry Infectious Disease Module Impact on Clinical Practice. 国防部创伤登记处传染病模块对临床实践的影响。
Pub Date : 2022-05-01 DOI: 10.1093/milmed/usac050
D. Tribble, M. Spott, Stacey A Shackleford, J. Gurney, Bg Clinton K Murray
BACKGROUNDThe Joint Trauma System (JTS) is a DoD Center of Excellence for Military Health System trauma care delivery and the DoD's reference body for trauma care in accordance with National Defense Authorization Act for Fiscal Year 2017. Through the JTS, evidence-based clinical practice guidelines (CPGs) have been developed and subsequently refined to standardize and improve combat casualty care. Data are amassed through a single, centralized DoD Trauma Registry to support process improvement measures with specialty modules established as the registry evolved. Herein, we review the implementation of the JTS DoD Trauma Registry specialty Infectious Disease Module and the development of infection-related CPGs and summarize published findings on the subsequent impact of the Infectious Disease Module on combat casualty care clinical practice and guidelines.METHODSThe DoD Trauma Registry Infectious Disease Module was developed in collaboration with the Infectious Disease Clinical Research Program (IDCRP) Trauma Infectious Disease Outcomes Study (TIDOS). Infection-related information (e.g., syndromes, antibiotic management, and microbiology) were collected from military personnel wounded during deployment June 1, 2009 through December 31, 2014 and medevac'd to Landstuhl Regional Medical Center in Germany before transitioning to participating military hospitals in the USA.RESULTSTo support process improvements and reduce variation in practice patterns, data collected through the Infectious Disease Module have been utilized in TIDOS analyses focused on assessing compliance with post-trauma antibiotic prophylaxis recommendations detailed in JTS CPGs. Analyses examined compliance over three time periods: 6 months, one-year, and 5 years. The five-year analysis demonstrated significantly improved adherence to recommendations following the dissemination of the 2011 JTS CPG, particularly with open fractures (34% compliance compared to 73% in 2013-2014). Due to conflicting recommendations regarding use of expanded Gram-negative coverage with open fractures, infectious outcomes among patients with open fractures who received cefazolin or expanded Gram-negative coverage (cefazolin plus fluoroquinolones and/or aminoglycosides) were also examined in a TIDOS analysis. The lack of a difference in the proportion of osteomyelitis (8% in both groups) and the significantly greater recovery of Gram-negative organisms resistant to aminoglycosides or fluoroquinolones among patients who received expanded Gram-negative coverage supported JTS recommendations regarding the use of cefazolin with open fractures. Following recognition of the outbreak of invasive fungal wound infections (IFIs) among blast casualties injured in Afghanistan, the ID Module was refined to capture data (e.g., fungal culture and histopathology findings, wound necrosis, and antifungal management) needed for the TIDOS team to lead the DoD outbreak investigation. These data captured through the In
背景联合创伤系统(JTS)是国防部军事卫生系统创伤护理卓越中心,也是国防部根据2017财年《国防授权法》进行创伤护理的参考机构。通过JTS,制定并完善了循证临床实践指南(CPG),以规范和改进战斗伤亡护理。数据是通过一个单一的、集中的国防部创伤登记处收集的,以支持随着登记处的发展而建立的专业模块的流程改进措施。在此,我们回顾了JTS国防部创伤登记处专业传染病模块的实施和感染相关CPG的开发,并总结了已发表的关于传染病模块对战斗伤亡护理临床实践和指南的后续影响的研究结果。方法国防部创伤登记处传染病模块是与传染病临床研究计划(IDCRP)创伤传染病结果研究(TIDOS)合作开发的。感染相关信息(如综合征、抗生素管理和微生物学)是从2009年6月1日至12月31日部署期间受伤的军事人员中收集的,2014年,在过渡到美国参与的军事医院之前,医疗后送到德国兰茨图尔地区医疗中心。RESULTST支持流程改进并减少实践模式的变化,通过传染病模块收集的数据已用于TIDOS分析,重点是评估创伤后抗生素预防建议的符合性,详见JTS CPG。分析检查了三个时间段的合规性:6 月、一年和5 年。五年期分析表明,2011年JTS CPG发布后,对建议的依从性显著提高,尤其是开放性骨折(34%的依从性,而2013-2014年为73%)。由于对开放性骨折使用扩大的革兰氏阴性覆盖率的建议存在冲突,在TIDOS分析中还检查了接受头孢唑林或扩大的革兰氏阳性覆盖率(头孢唑林加氟喹诺酮类和/或氨基糖苷类)治疗的开放性骨折患者的感染结果。在接受扩大革兰氏阴性覆盖的患者中,骨髓炎的比例没有差异(两组均为8%),并且对氨基糖苷类或氟喹诺酮类药物耐药的革兰氏阴性菌的恢复率明显更高,这支持了JTS关于在开放性骨折中使用头孢唑林的建议。在确认阿富汗爆炸伤亡人员中爆发侵袭性真菌伤口感染(IFI)后,对ID模块进行了改进,以获取TIDOS团队领导国防部疫情调查所需的数据(如真菌培养和组织病理学结果、伤口坏死和抗真菌管理)。通过传染病模块获取的这些数据为制定用于预防和管理IFI的JTS CPG提供了支持,该CPG后来根据随后的TIDOS IFI分析进行了改进。结论为了改善战斗伤亡护理结果,减轻未来冲突中的高后果感染,特别是在长期野战护理的情况下,需要扩大、完善国防部创伤登记传染病模块的可持续性机制,以包括对传染病趋势和结果的实时监测。
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引用次数: 6
IDCRP Trauma-Related Infection Research. IDCRP创伤相关感染研究。
Pub Date : 2022-05-01 DOI: 10.1093/milmed/usab508
D. Tribble
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引用次数: 1
Multidrug-Resistant and Virulent Organisms Trauma Infections: Trauma Infectious Disease Outcomes Study Initiative. 多重耐药和毒性生物创伤感染:创伤传染病结果研究倡议。
Pub Date : 2022-05-01 DOI: 10.1093/milmed/usab131
K. Mende, K. Akers, Stuart D. Tyner, J. Bennett, M. Simons, D. Blyth, Ping Li, L. Stewart, D. Tribble
INTRODUCTIONDuring the wars in Iraq and Afghanistan, increased incidence of multidrug-resistant (MDR) organisms, as well as polymicrobial wounds and infections, complicated the management of combat trauma-related infections. Multidrug resistance and wound microbiology are a research focus of the Trauma Infectious Disease Outcomes Study (TIDOS), an Infectious Disease Clinical Research Program, Uniformed Services University, research protocol. To conduct comprehensive microbiological research with the goal of improving the understanding of the complicated etiology of wound infections, the TIDOS MDR and Virulent Organisms Trauma Infections Initiative (MDR/VO Initiative) was established as a collaborative effort with the Brooke Army Medical Center, Naval Medical Research Center, U.S. Army Institute of Surgical Research, and Walter Reed Army Institute of Research. We provide a review of the TIDOS MDR/VO Initiative and summarize published findings.METHODSAntagonism and biofilm formation of commonly isolated wound bacteria (e.g., ESKAPE pathogens-Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), antimicrobial susceptibility patterns, and clinical outcomes are being examined. Isolates collected from admission surveillance swabs, as part of infection control policy, and clinical infection workups were retained in the TIDOS Microbiological Repository and associated clinical data in the TIDOS database.RESULTSOver the TIDOS study period (June 2009 to December 2014), more than 8,300 colonizing and infecting isolates were collected from military personnel injured with nearly one-third of isolates classified as MDR. At admission to participating U.S. military hospitals, 12% of wounded warriors were colonized with MDR Gram-negative bacilli. Furthermore, 27% of 913 combat casualties with ≥1 infection during their trauma hospitalization had MDR Gram-negative bacterial infections. Among 335 confirmed combat-related extremity wound infections (2009-2012), 61% were polymicrobial and comprised various combinations of Gram-negative and Gram-positive bacteria, yeast, fungi, and anaerobes. Escherichia coli was the most common Gram-negative bacilli isolated from clinical workups, as well as the most common colonizing MDR secondary to extended-spectrum β-lactamase resistance. Assessment of 479 E. coli isolates collected from wounded warriors found 188 pulsed-field types (PFTs) from colonizing isolates and 54 PFTs from infecting isolates without significant overlap across combat theaters, military hospitals, and study years. A minority of patients with colonizing E. coli isolates developed subsequent infections with the same E. coli strain. Enterococcus spp. were most commonly isolated from polymicrobial wound infections (53% of 204 polymicrobial cultures). Patients with Enterococcus infections were severely injured with a high proportion of lower extremity amputations and ge
在伊拉克和阿富汗战争期间,耐多药(MDR)微生物以及多微生物伤口和感染的发病率增加,使战斗创伤相关感染的管理复杂化。多药耐药和伤口微生物学是创伤传染病结果研究(TIDOS)的研究重点,这是军警大学传染病临床研究项目,研究方案。为了开展全面的微生物学研究,以提高对伤口感染复杂病因的理解,TIDOS MDR和有毒生物创伤感染倡议(MDR/VO倡议)是与布鲁克陆军医学中心、海军医学研究中心、美国陆军外科研究所和沃尔特里德陆军研究所共同努力建立的。我们提供了TIDOS MDR/VO倡议的回顾,并总结了已发表的研究结果。方法对ESKAPE病原菌(如粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌)的拮抗作用和生物膜形成、抗菌药物敏感性模式和临床结果进行研究。作为感染控制政策的一部分,从入院监测拭子中收集的分离株和临床感染检查保存在TIDOS微生物库中,并将相关临床数据保存在TIDOS数据库中。结果在2009年6月至2014年12月的TIDOS研究期间,从受伤的军事人员中收集了8300多株定植和感染分离株,其中近三分之一的分离株被归类为MDR。在美国参与的军事医院入院时,12%的受伤战士被MDR革兰氏阴性杆菌定植。此外,在创伤住院期间感染≥1次的913名战斗伤亡者中,27%为耐多药革兰氏阴性细菌感染。在335例确诊的战斗相关肢体伤口感染(2009-2012年)中,61%为多微生物感染,包括革兰氏阴性菌和革兰氏阳性菌、酵母菌、真菌和厌氧菌的各种组合。大肠杆菌是临床检出的最常见的革兰氏阴性杆菌,也是继发于广谱β-内酰胺酶耐药的最常见定植耐多药。对从受伤战士身上收集的479株大肠杆菌进行了评估,发现定植分离株中有188种脉冲场型(PFTs),感染分离株中有54种脉冲场型(PFTs),在战区、军队医院和研究年份之间没有明显的重叠。少数有定植大肠杆菌分离株的患者随后发生了相同大肠杆菌菌株的感染。肠球菌最常见于多微生物伤口感染(204例多微生物培养中有53%)。肠球菌感染的患者损伤严重,下肢截肢和泌尿生殖系统损伤的比例很高。大约65%的多微生物肠球菌感染分离出其他ESKAPE微生物。由于生物膜被认为是伤口延迟愈合的原因,因此对细菌持续恢复的伤口感染(同一生物分离株相隔≥14天)和非复发性细菌分离株进行了评估。生物膜的产生与复发性细菌分离显著相关(97% vs. 59%与非复发性分离;p < 0.001);然而,需要进一步的分析来证实生物膜的形成是持续伤口感染的预测因子。结论:TIDOS MDR/VO倡议提供了与战斗相关伤口感染相关的主要微生物威胁的全面和详细数据,以进一步了解伤口病因,并可能确定传染病对策,这可能导致战斗伤员护理的改善。
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引用次数: 6
DoD-VA Trauma Infection Research Collaboration. DoD-VA创伤感染研究合作。
Pub Date : 2022-05-01 DOI: 10.1093/milmed/usab482
Jay McDonald, S. Liang, Ping Li, L. Stewart, D. Tribble
BACKGROUNDIn the aftermath of wars, there is a surge in the number of wounded service members who leave active duty and become eligible for healthcare through the Department of Veterans Affairs (VA). Collaborations between the Department of Defense (DoD) and VA are crucial to capture comprehensive data and further understand the long-term impact of battlefield trauma. We provide a summary of the development, methodology, and status of an effective collaboration between the Infectious Disease Clinical Research Program and the St. Louis VA Health Care System with the multicenter, observational Trauma Infectious Disease Outcomes Study (TIDOS), which examines the short- and long-term outcomes of deployment-related trauma.METHODSAs part of TIDOS, wounded service members who transitioned to participating military hospitals in the United States (2009-2014) were given the opportunity to enroll in a prospective follow-up cohort study to continue to capture infection-related data after their hospital discharge. Enrollees in the TIDOS cohort who left military service and received health care through the VA also had the option of consenting to have relevant VA medical records abstracted and included with the study data. Infections considered to be complications resulting from the initial trauma were examined.RESULTSAmong 1,336 TIDOS enrollees, 1,221 (91%) registered and received health care through the VA with 633 (47%) consenting to follow-up using VA records and comprising the TIDOS-VA cohort. Of the first 337 TIDOS-VA cohort enrollees, 38% were diagnosed with a new trauma-related infection following hospital discharge (median: 88 days; interquartile range: 18-351 days). Approximately 71% of the infections were identified through DoD sources (medical records and follow-up) and 29% were identified through VA electronic medical records, demonstrating the utility of DoD-VA collaborations. The TIDOS DoD-VA collaboration has also been utilized to assess intermediate and long-term consequences of specific injury patterns. Among 89 TIDOS-VA cohort enrollees with genitourinary trauma, 36% reported sexual dysfunction, 21% developed at least one urinary tract infection, 14% had urinary retention/incontinence, and 8% had urethral stricture. The rate of urinary tract infections was 0.05/patient-year during DoD follow-up time and 0.07/patient-year during VA follow-up time.CONCLUSIONSWider capture of infection-related outcome data through the DoD-VA collaboration provided a clearer picture of the long-term infection burden resulting from deployment-related trauma. Planned analyses include assessment of osteomyelitis among combat casualties with amputations and/or open fractures, evaluation of mental health and social factors related to injury patterns, and examination of health care utilization and cost in relation to infectious disease burdens.
背景在战争结束后,离开现役并有资格通过退伍军人事务部(VA)获得医疗保健的受伤军人人数激增。国防部(DoD)和退伍军人事务部之间的合作对于获取全面数据和进一步了解战场创伤的长期影响至关重要。我们总结了传染病临床研究计划和弗吉尼亚州圣路易斯市卫生保健系统与多中心观察性创伤传染病结果研究(TIDOS)之间有效合作的发展、方法和现状,该研究考察了部署相关创伤的短期和长期结果。方法作为TIDOS的一部分,过渡到美国参与军事医院(2009-2014年)的受伤军人有机会参加一项前瞻性随访队列研究,以在出院后继续获取感染相关数据。TIDOS队列中退出兵役并通过退伍军人事务部接受医疗保健的参与者也可以选择同意提取退伍军人事务部的相关医疗记录并将其纳入研究数据。对被认为是最初创伤引起的并发症的感染进行了检查。结果在1336名TIDOS注册者中,1221人(91%)通过VA注册并接受医疗保健,633人(47%)同意使用VA记录进行随访,并包括TIDOS-VA队列。在首批337名TIDOS-VA队列参与者中,38%在出院后被诊断为新的创伤相关感染(中位数:88 天;四分位间距:18-351 天)。大约71%的感染是通过国防部的来源(医疗记录和随访)确定的,29%是通过退伍军人事务部的电子医疗记录确定的,这表明了国防部与退伍军人事务部合作的效用。TIDOS-DoD-VA合作也被用于评估特定损伤模式的中期和长期后果。在89名患有泌尿生殖系统创伤的TIDOS-VA队列参与者中,36%报告性功能障碍,21%至少发生一次尿路感染,14%有尿潴留/失禁,8%有尿道狭窄。在DoD随访期间,尿路感染率为0.05/年,在VA随访期间为0.07/年。结论通过国防部与退伍军人事务部的合作,对感染相关的结果数据进行了全面的收集,从而更清楚地了解了部署相关创伤造成的长期感染负担。计划中的分析包括评估截肢和/或开放性骨折战斗伤亡人员的骨髓炎,评估与损伤模式相关的心理健康和社会因素,以及检查与传染病负担相关的医疗保健利用和成本。
{"title":"DoD-VA Trauma Infection Research Collaboration.","authors":"Jay McDonald, S. Liang, Ping Li, L. Stewart, D. Tribble","doi":"10.1093/milmed/usab482","DOIUrl":"https://doi.org/10.1093/milmed/usab482","url":null,"abstract":"BACKGROUND\u0000In the aftermath of wars, there is a surge in the number of wounded service members who leave active duty and become eligible for healthcare through the Department of Veterans Affairs (VA). Collaborations between the Department of Defense (DoD) and VA are crucial to capture comprehensive data and further understand the long-term impact of battlefield trauma. We provide a summary of the development, methodology, and status of an effective collaboration between the Infectious Disease Clinical Research Program and the St. Louis VA Health Care System with the multicenter, observational Trauma Infectious Disease Outcomes Study (TIDOS), which examines the short- and long-term outcomes of deployment-related trauma.\u0000\u0000\u0000METHODS\u0000As part of TIDOS, wounded service members who transitioned to participating military hospitals in the United States (2009-2014) were given the opportunity to enroll in a prospective follow-up cohort study to continue to capture infection-related data after their hospital discharge. Enrollees in the TIDOS cohort who left military service and received health care through the VA also had the option of consenting to have relevant VA medical records abstracted and included with the study data. Infections considered to be complications resulting from the initial trauma were examined.\u0000\u0000\u0000RESULTS\u0000Among 1,336 TIDOS enrollees, 1,221 (91%) registered and received health care through the VA with 633 (47%) consenting to follow-up using VA records and comprising the TIDOS-VA cohort. Of the first 337 TIDOS-VA cohort enrollees, 38% were diagnosed with a new trauma-related infection following hospital discharge (median: 88 days; interquartile range: 18-351 days). Approximately 71% of the infections were identified through DoD sources (medical records and follow-up) and 29% were identified through VA electronic medical records, demonstrating the utility of DoD-VA collaborations. The TIDOS DoD-VA collaboration has also been utilized to assess intermediate and long-term consequences of specific injury patterns. Among 89 TIDOS-VA cohort enrollees with genitourinary trauma, 36% reported sexual dysfunction, 21% developed at least one urinary tract infection, 14% had urinary retention/incontinence, and 8% had urethral stricture. The rate of urinary tract infections was 0.05/patient-year during DoD follow-up time and 0.07/patient-year during VA follow-up time.\u0000\u0000\u0000CONCLUSIONS\u0000Wider capture of infection-related outcome data through the DoD-VA collaboration provided a clearer picture of the long-term infection burden resulting from deployment-related trauma. Planned analyses include assessment of osteomyelitis among combat casualties with amputations and/or open fractures, evaluation of mental health and social factors related to injury patterns, and examination of health care utilization and cost in relation to infectious disease burdens.","PeriodicalId":86137,"journal":{"name":"Military surgeon","volume":"187 Supplement_2 1","pages":"17-24"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43970530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
IDCRP Combat-Related Extremity Wound Infection Research. IDCRP与战斗相关的四肢创伤感染研究。
Pub Date : 2022-05-01 DOI: 10.1093/milmed/usab065
Joseph L. Petfield, Louis R. Lewandowski, L. Stewart, C. Murray, D. Tribble
INTRODUCTIONExtremity trauma is the most common battlefield injury, resulting in a high frequency of combat-related extremity wound infections (CEWIs). As these infections are associated with substantial morbidity and may impact wounded warriors long after initial hospitalization, CEWIs have been a focus of the Infectious Disease Clinical Research Program (IDCRP). Herein, we review findings of CEWI research conducted through the IDCRP and discuss future and ongoing analyses.METHODSMilitary personnel with deployment-related trauma sustained between 2009 and 2014 were examined in retrospective analyses through the observational Trauma Infectious Disease Outcomes Study (TIDOS). Characteristics of wounded warriors with ≥1 open extremity wound were assessed, focusing on injury patterns and infection risk factors. Through a separate trauma-associated osteomyelitis study, military personnel with combat-related open fractures of the long bones (tibia, femur, and upper extremity) sustained between 2003 and 2009 were examined to identify osteomyelitis risk factors.RESULTSAmong 1,271 wounded warriors with ≥1 open extremity wound, 16% were diagnosed with a CEWI. When assessed by their most severe extremity injury (i.e., amputation, open fracture, or open soft-tissue wound), patients with amputations had the highest proportion of infections (47% of 212 patients with traumatic amputations). Factors related to injury pattern, mechanism, and severity were independent predictors of CEWIs during initial hospitalization. Having a non-extremity infection at least 4 days before CEWI diagnosis was associated with reduced likelihood of CEWI development. After hospital discharge, 28% of patients with extremity trauma had a new or recurrent CEWI during follow-up. Risk factors for the development of CEWIs during follow-up included injury pattern, having either a CEWI or other infection during initial hospitalization, and receipt of antipseudomonal penicillin for ≥7 days. A reduced likelihood for CEWIs during follow-up was associated with a hospitalization duration of 15-30 days. Under the retrospective osteomyelitis risk factor analysis, patients developing osteomyelitis had higher open fracture severity based on Gustilo-Anderson (GA) and the Orthopaedic Trauma Association classification schemes and more frequent traumatic amputations compared to open fracture patients without osteomyelitis. Recurrence of osteomyelitis was also common (28% of patients with open tibia fractures had a recurrent episode). Although osteomyelitis risk factors differed between the tibia, femur, and upper extremity groups, sustaining an amputation, use of antibiotic beads, and being injured in the earlier years of the study (before significant practice pattern changes) were consistent predictors. Other risk factors included GA fracture severity ≥IIIb, blast injuries, foreign body at fracture site (with/without orthopedic implant), moderate/severe muscle damage and/or necrosis, and moder
简介肢体创伤是最常见的战场损伤,导致与战斗相关的肢体创伤感染(CEWIs)的频率很高。由于这些感染与严重的发病率有关,并且可能在首次住院后很长一段时间内影响受伤的战士,因此CEWI一直是传染病临床研究计划(IDCRP)的重点。在此,我们回顾了通过IDCRP进行的CEWI研究结果,并讨论了未来和正在进行的分析。方法通过观察性创伤传染病结果研究(TIDOS)对2009年至2014年间遭受部署相关创伤的军事人员进行回顾性分析。对四肢开放性创伤≥1例的伤员的特征进行了评估,重点关注损伤模式和感染风险因素。通过另一项与创伤相关的骨髓炎研究,对2003年至2009年间遭受战斗相关长骨(胫骨、股骨和上肢)开放性骨折的军事人员进行了检查,以确定骨髓炎的危险因素。结果1271名四肢开放性创伤≥1处的伤员中,16%被诊断为CEWI。当根据最严重的肢体损伤(即截肢、开放性骨折或开放性软组织伤口)进行评估时,截肢患者的感染比例最高(212名创伤性截肢患者中有47%)。与损伤模式、机制和严重程度相关的因素是初次住院期间CEWIs的独立预测因素。在CEWI诊断前至少4天发生非四肢感染与CEWI发展的可能性降低有关。出院后,28%的四肢创伤患者在随访期间出现了新的或复发的CEWI。随访期间发生CEWI的风险因素包括损伤模式、首次住院期间发生CEWIs或其他感染,以及接受抗假阳性青霉素≥7天。随访期间发生CEWIs的可能性降低与15-30天的住院时间有关。根据回顾性骨髓炎危险因素分析,根据Gustilo Anderson(GA)和骨科创伤协会分类方案,患有骨髓炎的患者开放性骨折的严重程度更高,与没有骨髓炎的开放性骨折患者相比,创伤性截肢更频繁。骨髓炎的复发也很常见(28%的胫骨开放性骨折患者有复发)。尽管胫骨、股骨和上肢组的骨髓炎危险因素不同,但在研究的早期(在显著的实践模式改变之前),截肢、使用抗生素珠和受伤是一致的预测因素。其他危险因素包括GA骨折严重程度≥IIIb、爆炸伤、骨折部位异物(有/没有骨科植入物)、中度/重度肌肉损伤和/或坏死以及中度/重度皮肤/软组织损伤。对于上肢开放性骨折,从战区撤离后的初步稳定与骨髓炎的可能性降低有关。结论未来的研究将检验常见抗生素方案治疗四肢深部软组织感染的有效性,以改善战斗伤亡的临床结果,并支持制定CEWI治疗的临床实践指南。将通过国防部和退伍军人事务部的随访,以及对合并症和心理健康/社会因素的影响进行检查,进一步调查肢体创伤和由此产生的感染的长期影响。
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引用次数: 5
SARS-CoV-2 Vaccine Acceptance Disparity Among Israeli Defense Forces Personnel. 以色列国防军人员接受SARS-CoV-2疫苗的差异
Pub Date : 2022-04-27 DOI: 10.1093/milmed/usac122
Galina Shapiro, Maxim Bez, Tomer Talmy, Josef Daniel Shakargy, Ariel Furer, Erez Karp, David Segal

Introduction: Promoting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine acceptance and uptake became necessary to achieve a high vaccination rate and subsequently herd immunity. Although the Israeli population has been largely acceptant of the SARS-CoV-2 vaccine, vaccine hesitancy has remained a major concern, especially in younger adults. We hypothesized that young adults who refused SARS-CoV-2 vaccination differed from those who have been adherent and could be characterized. Studying this specific population and recognizing individuals within this group who might be more probable to refuse vaccination can enable to target measures to further promote vaccination acceptance.

Methods: We conducted a cross-sectional comparison in a study population comprised of 17,435 Israeli Defense Forces (IDF) personnel who were SARS-CoV-2 vaccine eligible. This group included 14,834 vaccinated and 2,601 nonvaccinated individuals. Patient characteristics including occupational parameters, demographic features, psychotechnical grading (an intelligence assessment score), education level, and medical background were collected.

Results: The median age was 20.57 years and almost 80% were males. At the time of data collection, most individuals (85.1%, n = 14,834) have been vaccinated. Officers and noncommissioned officers were more likely to be vaccinated compared with regular soldiers (96%, and 90.2% vs. 83.3% respectively, P < .001), as well as combat battalions stationed personnel compared to their peers in rear and administrative units (89.4% vs. 78.4%, P < .001). Socioeconomic clusters were also associated with vaccination adherence, with 92.9% vs. 79.5% vaccination rates in the highest and lowest clusters, respectively (P < .001). Younger age, no previous immigration status, higher education level, and higher psychotechnical grades were also found associated with an increased likelihood of being vaccinated (P < .001).

Conclusions: In a large cohort of enlisted IDF personnel, disparity in SARS-CoV-2 vaccine adherence was found to be related to multiple socioeconomic, educational, and military service-related variables. Although some differences were substantial, others were small and of questionable public health significance. Acknowledging these differences may enable community leaders, health care providers, and administrators to target specific populations in order to further promote SARS-CoV-2 vaccination acceptance.

促进严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)疫苗的接受和摄取是实现高疫苗接种率和随后的群体免疫的必要条件。尽管以色列人口在很大程度上接受了SARS-CoV-2疫苗,但疫苗犹豫仍然是一个主要问题,特别是在年轻人中。我们假设拒绝接种SARS-CoV-2疫苗的年轻人与接种过疫苗的年轻人不同,并且可能具有特征。研究这一特定人群,并认识到这一群体中更有可能拒绝接种疫苗的个体,可以采取有针对性的措施,进一步促进疫苗接种的接受。方法我们对17435名符合SARS-CoV-2疫苗条件的以色列国防军(IDF)人员进行了横断面比较。这一组包括14,834名接种疫苗的人和2,601名未接种疫苗的人。收集患者特征,包括职业参数、人口统计学特征、心理技术评分(智力评估分数)、教育水平和医学背景。结果中位年龄为20.57岁,男性占80%。在收集数据时,大多数人(85.1%,n = 14,834)已接种疫苗。军官和士官比正规兵更有可能接种疫苗(分别为96%,90.2%和83.3%,P < 0.001),战斗营驻扎人员比后方和行政单位的同行更有可能接种疫苗(89.4%比78.4%,P < 0.001)。社会经济集群也与疫苗接种依从性相关,最高和最低集群的疫苗接种率分别为92.9%和79.5% (P < 0.001)。年龄较小、以前没有移民身份、较高的教育水平和较高的心理技术等级也与接种疫苗的可能性增加有关(P < 0.001)。结论在一大批以色列国防军士兵中,SARS-CoV-2疫苗依从性的差异与社会经济、教育和兵役相关的多个变量有关。虽然有些差异很大,但其他差异很小,对公共卫生的意义值得怀疑。认识到这些差异可能使社区领导人、卫生保健提供者和管理人员能够针对特定人群,以进一步促进接受SARS-CoV-2疫苗接种。
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引用次数: 0
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Military surgeon
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