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Comparison of distal extremity magnetic resonance imaging findings in Australian racing Standardbreds and Thoroughbreds 澳大利亚赛马标准马和纯血马远端肢体磁共振成像结果的比较。
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-28 DOI: 10.1111/avj.13372
M Stutsel, L Jordan, C Smith, WY Lee, N Symonds, RJW Bell, A Young

Introduction

Foot-related lameness is common in Standardbred and Thoroughbred racehorses. Magnetic resonance imaging (MRI) provides information on both the soft tissue and osseous structures of the distal extremity. The aim of this study was to determine whether abnormalities identified on distal limb MRI differed between these two racehorse populations.

Materials and Methods

The records of Standardbred and Thoroughbred racehorse distal extremity MRI examinations conducted at Camden Equine Centre and Ballarat Veterinary Practice between 2013 and 2023 were retrieved. Horses were included if pain causing lameness had been localised to the foot using perineural or intra-articular analgesia. MRI abnormalities of the structures within the distal extremity were recorded and comparisons made between the two groups.

Results

There was a significant difference in the rate of occurrence of certain MRI abnormalities between the Thoroughbred and Standardbred racehorse populations, including distal phalangeal fractures, proximal phalangeal short tau inversion recovery (STIR) hyperintensity (distal aspect), the presence and severity of ungular cartilage ossification, abnormalities of the navicular bone distal border synovial invaginations/vascular channels and navicular bone distal border fragments. The presence of distal extremity STIR hyperintensity and fractures was significantly higher in Standardbred compared to Thoroughbred racehorses when these findings were grouped and considered in combination.

Conclusion

There were many similarities in the distal extremity MRI abnormalities identified in lame Australian Standardbred and Thoroughbred racehorses. However, distal phalangeal fractures, ungular cartilage ossification and distal extremity STIR hyperintensity were identified in significantly more in Standardbred than Thoroughbred racehorses.

简介:与足部有关的跛足在标准赛马和纯血赛马中很常见。磁共振成像(MRI)可提供四肢远端软组织和骨结构的信息。本研究旨在确定这两种赛马远端肢体核磁共振成像检查出的异常情况是否存在差异:检索了 2013 年至 2023 年期间在卡姆登马术中心和巴拉瑞特兽医诊所进行的标准种马和纯血马赛马四肢远端核磁共振成像检查记录。如果使用硬膜外镇痛或关节内镇痛将导致跛足的疼痛定位在足部,则将马匹纳入检查范围。记录四肢远端结构的核磁共振成像异常情况,并对两组马进行比较:结果:纯血马和标准种赛马的某些核磁共振成像异常发生率存在明显差异,包括远端趾骨骨折、近端趾骨短头反转恢复(STIR)高强度(远端)、非锣状软骨骨化的存在和严重程度、舟骨远端边缘滑膜内陷/血管通道异常和舟骨远端边缘碎片。如果对这些结果进行分组和综合考虑,标准赛马远端肢体 STIR 高强度和骨折的发生率明显高于纯血赛马:在瘸腿的澳大利亚标准赛马和纯血赛马身上发现的四肢远端磁共振成像异常有许多相似之处。但是,标准赛马远端趾骨骨折、非锣状软骨骨化和远端肢体 STIR 高强度的发现明显多于纯血赛马。
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引用次数: 0
Computed tomographic features of segmental aplasia of the caudal vena cava, portocaval shunt and Situs ambiguous in two dogs 两只狗尾部腔静脉节段性发育不全、门-腔分流和坐骨不清的计算机断层扫描特征。
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-25 DOI: 10.1111/avj.13373
J Desbordes, T Brignon, H Gaillot

A 3-year-old crossbreed dog (case 1) and a 3-month-old German Shorthaired Pointer (case 2) were presented for acute signs of encephalopathy. A portosystemic shunt (PSS) was suspected based on clinical context and laboratory exam results and was confirmed on computed tomography (CT) angiography in both cases. A left-sided azygos (case 1) and right-sided azygos (case 2) continuation of an interrupted caudal vena cava (CVC) and a situs ambiguous (SA) were also observed and considered as incidental findings. Both dogs underwent PSS surgical correction. Postsurgical follow-up imaging procedures suggested concomitant primary hypoplasia of the portal vein (PHPV) in both cases.

一只 3 岁大的杂交犬(病例 1)和一只 3 个月大的德国短毛猎犬(病例 2)因出现急性脑病症状而就诊。根据临床症状和实验室检查结果,怀疑是门静脉分流(PSS),两例病例均经计算机断层扫描(CT)血管造影证实。此外,还观察到左侧颧静脉(病例 1)和右侧颧静脉(病例 2)延续中断的尾腔静脉(CVC)以及坐位不清(SA),并将其视为偶然发现。两只狗都接受了 PSS 手术矫正。手术后的随访影像学检查显示,两例病例均伴有原发性门静脉发育不全(PHPV)。
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引用次数: 0
Vale Harvey Arthur Westbury BVSc Hons, MVSc, PhD, DVSc (1941–2024) 维尔-哈维-阿瑟-韦斯特伯里 BVSc 荣誉学位、MVSc 博士、DVSc(1941-2024 年)
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-12 DOI: 10.1111/avj.13366
K McColl
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引用次数: 0
Using EPIWATCH® open-source surveillance to describe the epidemiology of lumpy skin disease outbreaks in South and Southeast Asia (2022–2023) 利用 EPIWATCH® 开放源码监测描述南亚和东南亚块状皮肤病暴发的流行病学(2022-2023 年)。
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-26 DOI: 10.1111/avj.13362
D Hutchinson, B Li, S Lim, H Stone, CR MacIntyre

Lumpy skin disease (LSD) poses a significant threat to animal welfare and leads to economic losses in affected countries. LSD outbreaks may also impact trade and regional relationships. South and Southeast Asia, with its dense livestock population and intricate trade networks, are susceptible to LSD outbreaks. Indonesia confirmed its first LSD cases in March 2022, leading to substantial livestock losses by August 2023. Australia, an important player in the global beef industry, faced trade disruptions due to LSD concerns raised by Indonesia and Malaysia, claims that were refuted by Australian authorities. The dispute highlights the need for good surveillance. EPIWATCH®, employing artificial intelligence, provides real-time outbreak signals, and spatial analysis can identify LSD hotspots, leading to timely interventions. This study uses data collected by the EPIWATCH® open-source disease surveillance system at the University of New South Wales in 2022 and 2023 and compares it for timeliness and completeness with data available on the World Animal Health Information System (WAHIS). We found more timely reports of LSD outbreaks in EPIWATCH® compared to WAHIS. In conclusion, open-source surveillance tools like EPIWATCH® can provide timely alerts of disease emergence, such as LSD outbreaks in South and Southeast Asia, which can supplement formal reporting systems.

结节性皮肤病(LSD)对动物福利构成重大威胁,并导致受影响国家的经济损失。LSD 的爆发还可能影响贸易和区域关系。南亚和东南亚牲畜密集,贸易网络错综复杂,很容易爆发 LSD。印度尼西亚于 2022 年 3 月确诊了首例 LSD 病例,到 2023 年 8 月已导致大量牲畜死亡。澳大利亚是全球牛肉业的重要参与者,由于印尼和马来西亚提出的对 LSD 的担忧而面临贸易中断,但澳大利亚当局驳斥了印尼和马来西亚的说法。这一争端凸显了良好监控的必要性。采用人工智能的 EPIWATCH® 可提供实时疫情信号,空间分析可确定 LSD 的热点地区,从而及时采取干预措施。本研究使用了新南威尔士大学 EPIWATCH® 开源疾病监测系统在 2022 年和 2023 年收集的数据,并将其与世界动物卫生信息系统 (WAHIS) 中的数据进行了及时性和完整性比较。我们发现,与 WAHIS 相比,EPIWATCH® 能更及时地报告 LSD 的爆发。总之,像 EPIWATCH® 这样的开放源码监测工具可以及时发出疾病突发警报,如南亚和东南亚的 LSD 爆发,从而补充正式报告系统的不足。
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引用次数: 0
Suspected paraneoplastic syndrome of inappropriate antidiuretic hormone secretion associated with a gastric adenocarcinoma in a dog 疑似与胃腺癌有关的抗利尿激素分泌失调的副肿瘤综合征。
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-19 DOI: 10.1111/avj.13365
A Thomas, J Finlay, C Sharp

This report describes a suspected case of paraneoplastic syndrome of inappropriate antidiuretic hormone (SIADH) in a 5-year-old male entire Australian Kelpie associated with a gastric adenocarcinoma. The dog had a history of chronic vomiting and presented with hyponatraemia, hypokalaemia, hypochloraemia and increased urinary sodium. Computed tomography identified the presence of a gastric tumour and histopathology confirmed a pyloric gastric adenocarcinoma. Removal of the tumour via a Billroth I procedure resulted in rapid resolution of electrolyte derangements. The dog was still alive six months postoperatively with no recurrence of either SIADH or tumour at the time of publication.

本报告描述了一例疑似抗利尿激素不当副肿瘤综合征(SIADH)的病例,病犬是一只 5 岁的雄性澳大利亚海带犬,患有胃腺癌。该犬有慢性呕吐史,并伴有低钠血症、低钾血症、低氯血症和尿钠增加。计算机断层扫描确定了胃肿瘤的存在,组织病理学证实是幽门胃腺癌。通过比尔罗斯 I 型手术切除肿瘤后,电解质紊乱很快得到缓解。该犬术后六个月仍然存活,在发表文章时,SIADH 和肿瘤均未复发。
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引用次数: 0
Collaborative wildlife disease outbreak investigation and response at Bells Swamp Victoria, February 2023 2023 年 2 月,在维多利亚州贝尔沼泽开展野生动物疾病爆发调查和应对合作。
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-04 DOI: 10.1111/avj.13364
M McKimmie, HJ Morrow, MC Hawes, A Robins, M Lynch, K Bodley, F Ryan, K Cox-Witton, C Death, P Whiteley

In February 2023, a report of morbidity and mortality in waterbirds triggered a collaborative regional wildlife disease outbreak investigation and response, led by Parks Victoria. Triage, rehabilitation and diagnosis of sick and dead birds were undertaken by Zoos Victoria (ZV), Agriculture Victoria, Vets for Compassion, Wildlife Victoria and Melbourne Veterinary School (MVS). The field response focused on collection of sick and dead birds for wildlife welfare, for diagnosis, and to reduce environmental contamination. Botulism was suspected, based on clinical signs and lack of significant gross pathology, and this diagnosis was confirmed by PCR testing. Low pathogenicity avian influenza (LPAI) viruses non H5 or H7 were detected in two birds and ruled out in all in others tested. These incidental, non-clinical LPAI detections are considered part of the natural wild bird virus community in Australia. A number of elements contributed to the collaborative effort. Regional individuals had the necessary connections for reporting, collecting and transporting birds. There was rapid determination by the Victorian Department of Energy, Environment and Climate Action (DEECA) that Parks Victoria, as the land managers, should lead the response. Zoos Victoria provided capacity and expertise in wildlife triage and rehabilitation, and Agriculture Victoria, ZV and MVS were responsible for veterinary management of the response and diagnosis. Field investigation and response were conducted by Parks Victoria, Agriculture Victoria, MVS and veterinary teams from Vets for Compassion and Wildlife Victoria. Wildlife Health Australia (WHA) provided guidance and information, approved National Significant Disease Investigation Program funding and captured the event in the national wildlife health information database. Communication and media were important for community understanding of the event.

2023 年 2 月,一份关于水鸟发病和死亡的报告引发了一场由维多利亚公园牵头的地区性野生动物疾病爆发合作调查和应对行动。维多利亚州动物园 (ZV)、维多利亚州农业局 (Agriculture Victoria)、维多利亚州兽医同情协会 (Vets for Compassion)、维多利亚州野生动物协会 (Wildlife Victoria) 和墨尔本兽医学校 (MVS) 对病死鸟类进行了分流、康复和诊断。现场应对措施的重点是收集病鸟和死鸟,以维护野生动物福利、进行诊断并减少环境污染。根据临床症状和没有明显的大体病理变化,怀疑是肉毒杆菌中毒,这一诊断通过 PCR 检测得到了证实。在两只禽鸟中检测到了非 H5 或 H7 的低致病性禽流感病毒,在其他检测中排除了所有病毒。这些偶然检测到的非临床低致病性禽流感病毒被认为是澳大利亚天然野鸟病毒群的一部分。许多因素促成了合作努力。该地区的个人拥有报告、收集和运输鸟类的必要联系。维多利亚州能源、环境和气候行动部 (DEECA) 迅速决定,维多利亚州公园作为土地管理者应领导应对行动。维多利亚动物园提供了野生动物分流和康复方面的能力和专业知识,维多利亚州农业局、维多利亚州动物园和维多利亚州兽医局负责应对和诊断方面的兽医管理。实地调查和应对工作由维多利亚州公园管理局、维多利亚州农业局、维多利亚州兽医协会以及来自维多利亚州兽医协会和维多利亚州野生动物协会的兽医团队负责。澳大利亚野生动物健康组织 (WHA) 提供了指导和信息,批准了国家重大疾病调查计划的资金,并在国家野生动物健康信息数据库中记录了这一事件。沟通和媒体对于社区了解该事件非常重要。
{"title":"Collaborative wildlife disease outbreak investigation and response at Bells Swamp Victoria, February 2023","authors":"M McKimmie,&nbsp;HJ Morrow,&nbsp;MC Hawes,&nbsp;A Robins,&nbsp;M Lynch,&nbsp;K Bodley,&nbsp;F Ryan,&nbsp;K Cox-Witton,&nbsp;C Death,&nbsp;P Whiteley","doi":"10.1111/avj.13364","DOIUrl":"10.1111/avj.13364","url":null,"abstract":"<p>In February 2023, a report of morbidity and mortality in waterbirds triggered a collaborative regional wildlife disease outbreak investigation and response, led by Parks Victoria. Triage, rehabilitation and diagnosis of sick and dead birds were undertaken by Zoos Victoria (ZV), Agriculture Victoria, Vets for Compassion, Wildlife Victoria and Melbourne Veterinary School (MVS). The field response focused on collection of sick and dead birds for wildlife welfare, for diagnosis, and to reduce environmental contamination. Botulism was suspected, based on clinical signs and lack of significant gross pathology, and this diagnosis was confirmed by PCR testing. Low pathogenicity avian influenza (LPAI) viruses non H5 or H7 were detected in two birds and ruled out in all in others tested. These incidental, non-clinical LPAI detections are considered part of the natural wild bird virus community in Australia. A number of elements contributed to the collaborative effort. Regional individuals had the necessary connections for reporting, collecting and transporting birds. There was rapid determination by the Victorian Department of Energy, Environment and Climate Action (DEECA) that Parks Victoria, as the land managers, should lead the response. Zoos Victoria provided capacity and expertise in wildlife triage and rehabilitation, and Agriculture Victoria, ZV and MVS were responsible for veterinary management of the response and diagnosis. Field investigation and response were conducted by Parks Victoria, Agriculture Victoria, MVS and veterinary teams from Vets for Compassion and Wildlife Victoria. Wildlife Health Australia (WHA) provided guidance and information, approved National Significant Disease Investigation Program funding and captured the event in the national wildlife health information database. Communication and media were important for community understanding of the event.</p>","PeriodicalId":8661,"journal":{"name":"Australian Veterinary Journal","volume":"102 10","pages":"514-516"},"PeriodicalIF":1.3,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/avj.13364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to ‘What is the best treatment for hypotension in healthy dogs during anaesthesia maintained with isoflurane?’ 对 "在使用异氟醚维持麻醉期间,健康犬出现低血压的最佳治疗方法是什么?
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-02 DOI: 10.1111/avj.13359

Quinn, CT. What is the best treatment for hypotension in healthy dogs during anaesthesia maintained with isoflurane? Aust Vet J 2024;102:264–273. https://doi.org/10.1111/avj.13318

Terminological or typographical errors that affected the interpretation of the article have been amended throughout the above article. These corrections were due to copyediting mistakes that were not originally addressed during the preparation and publication of the original article. Corrections were made in the following sections.

Abstract: A typographical error regarding volatile anaesthetic agents has been amended.

Abbreviations: The term ‘urine output’ has been corrected.

Clinical scenario: Terminological or typographical errors that affected the interpretation of the text have been amended.

Critical appraisal of the evidence: Terminological or typographical errors that affected the interpretation of the text have been amended.

Table 2: The terminology ‘blood loss or prolonged water deprivation’ has been amended.

Table 4: Corrections have been made to amend numbers that should be represented as percentages.

Conflicts of interest and Sources of Funding: The correct name for ‘Charles Sturt University’ has been amended.

We apologize for the errors.

Quinn, CT.异氟醚麻醉期间健康犬低血压的最佳治疗方法是什么?Aust Vet J 2024;102:264-273。https://doi.org/10.1111/avj.13318Terminological,对影响文章解释的排版错误进行了修正。这些更正是由于在编写和发表原始文章时没有注意到的复制编辑错误造成的。对以下部分进行了更正。摘要:修改了关于挥发性麻醉剂的一处排印错误:缩写:"尿量 "一词已更正:临床情景:修改了影响文本解释的术语或排版错误:表2:对术语 "失血或长期缺水 "进行了修正。表4:对应表示为百分比的数字进行了修正:对 "查尔斯特大学 "的正确名称进行了修改。
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引用次数: 0
Severe cases of Buruli ulcer (infection with Mycobacterium ulcerans) in common ringtail possums in Victoria adversely affect animal welfare 维多利亚州普通环尾负鼠的布路里溃疡(溃疡分枝杆菌感染)严重影响了动物福利。
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-07-25 DOI: 10.1111/avj.13360
EC Hobbs, P Loukopoulos, TP Stinear, JL Porter, JYH Lee, P Whiteley, LF Skerratt, KB Gibney, A Meredith

Buruli ulcer is a chronic ulcerative disease of the skin and subcutaneous tissues caused by infection with Mycobacterium ulcerans. Although Australian possums are known to be susceptible to Buruli ulcer, many aspects of the disease in possums, including welfare impacts, remain largely unreported. Severe clinical Buruli ulcer was identified in four common ringtail possums (Pseudocheirus peregrinus) from Melbourne, Victoria. All four possums were euthanased due to the presence of deep ulcerative lesions on paws, with extensive tissue necrosis that exposed bones and tendons in three cases. Histologically, there was severe ulcerative necrotising pyogranulomatous dermatitis, panniculitis and myositis, with intralesional acid-fast bacteria. M. ulcerans was detected by real-time PCR in all swabs, tissues and faeces collected from all four cases. Buruli ulcer may be an important and under-recognised cause of poor possum welfare in endemic areas. The physical impacts of the severe cutaneous lesions, especially those extending to underlying bones and joints, would have directly impaired the mobility of these possums, affecting navigation of their natural environments and expression of natural behaviours including foraging and socialising. Systemic distribution of M. ulcerans throughout all major internal organs, as observed here, may further impact the health and fitness of infected possums. Faecal shedding of M. ulcerans in all four cases supports the role of possums as zoonotic reservoirs. Further research is needed to investigate the epidemiology, pathogenesis and welfare impacts of Buruli ulcer in possums and to inform the design of interventions that may protect their health and welfare.

布路里溃疡是一种由溃疡分枝杆菌感染引起的皮肤和皮下组织慢性溃疡病。虽然已知澳大利亚负鼠容易感染布路里溃疡病,但这种疾病对负鼠的许多方面,包括福利的影响,在很大程度上仍未得到报道。在维多利亚州墨尔本市的四只普通环尾负鼠(Pseudocheirus peregrinus)身上发现了严重的临床布里溃疡。这四只负鼠均因爪子出现深度溃疡性病变而被安乐死,其中三只负鼠的组织大面积坏死,骨头和肌腱外露。从组织学角度来看,这些负鼠患有严重的溃疡性坏死性化脓性皮炎、泛发性皮炎和肌炎,并伴有溃疡内的酸性细菌。通过实时聚合酶链式反应(real-time PCR),在所有四个病例的拭子、组织和粪便中都检测到了溃疡霉菌。布路里溃疡可能是流行地区负鼠福利不佳的一个重要原因,但人们对它的认识不足。严重的皮肤病变,尤其是延伸到骨骼和关节的病变,会直接损害负鼠的活动能力,影响它们在自然环境中的活动以及觅食和社交等自然行为的表达。这里观察到的溃疡曼氏菌在所有主要内脏器官的全身分布,可能会进一步影响受感染负鼠的健康和体能。所有四个病例的粪便中都有溃疡甲壳霉菌脱落,这支持了负鼠作为人畜共患病储库的作用。需要进一步研究负鼠布路里溃疡的流行病学、发病机制和对福利的影响,并为设计可能保护负鼠健康和福利的干预措施提供信息。
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引用次数: 0
Antiviral therapy in cats progressively infected with feline leukaemia virus: lessons from a series of 18 consecutive cases from Australia 对逐渐感染猫白血病病毒的猫进行抗病毒治疗:从澳大利亚 18 例连续病例中汲取的教训。
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-07-23 DOI: 10.1111/avj.13363
ME Westman, E Hall, JM Norris, T Meili, R Hofmann-Lehmann, R Malik
<div> <section> <h3> Background</h3> <p>It is doubtful that any of the treatments proposed for feline leukaemia virus (FeLV) infection are effective, despite the entity being described 60 years ago.</p> </section> <section> <h3> Methods</h3> <p>Eighteen pet cats with progressive FeLV infections were recruited in Australia. One or more antiviral drugs were trialled in 16 cats, while two FeLV-infected cats were not handleable and served as untreated controls. Six cats were administered RetroMAD1™ only (0.5 mg/kg orally twice daily), a commercially available recombinant chimeric protein with proposed antiretroviral activity. Three cats were administered the integrase inhibitor raltegravir only (10–15 mg/kg orally twice daily), a drug used as a component of highly effective antiretroviral therapy for human immunodeficiency virus (HIV-1) infection. Three cats were administered RetroMAD1™ and raltegravir concurrently, and four cats were administered raltegravir and the reverse transcriptase inhibitor zidovudine (AZT, 5 mg/kg orally twice daily) concurrently. FeLV RNA and p27 antigen loads were measured at two timepoints (T1-2 months and T3-5 months) during therapy and compared to baseline (pretreatment) levels, to assess the response to therapy using linear modelling. The median survival time (MST) of the cats from commencement of FeLV treatment to death was also determined and compared between treatments.</p> </section> <section> <h3> Results</h3> <p>The MST for the 16 FeLV-positive cats which received antiviral therapy was 634 days, while the MST from FeLV diagnosis to death for the two untreated control cats was 780 days. In cats treated with RetroMAD1™, FeLV viral load decreased from T0 to T1-2 months (median viral load reduced from 1339 × 10<sup>6</sup> to 705 × 10<sup>6</sup> copies/mL plasma; P = 0.012), but MST was reduced compared to cats not given RetroMAD1™ (426 days vs 1006 days; P = 0.049). Cats treated with raltegravir and AZT had no significant changes in FeLV viral load over time, but p27 antigen load was decreased from T0 to T3-5 months in cats treated with raltegravir (median p27 antigen level reduced from 50.2% to 42.7%; P = 0.005). All other results were not significantly affected by the treatment provided.</p> <p>Importantly, statistically significant and substantial associations were found between age at FeLV diagnosis and survival time (P = 0.046, R<sup>2</sup> = 18.6) and between FeLV viral load at T0 and survival time (P = 0.004, R<sup>2</sup> = 44.4). Younger cats, and cats with higher levels of pretreatment FeLV RNA, had reduced survival times. Cats treated with RetroMAD1™ were typically younger (median age 2.
背景:尽管猫白血病病毒(FeLV)感染早在 60 年前就已被描述,但目前提出的任何治疗方法是否有效都值得怀疑:方法:在澳大利亚招募了 18 只患有进行性 FeLV 感染的宠物猫。方法:在澳大利亚招募了 18 只患有渐进性 FeLV 感染的宠物猫,在 16 只猫中试用了一种或多种抗病毒药物,另外两只 FeLV 感染猫无法处理,作为未经治疗的对照组。六只猫只服用了 RetroMAD1™(0.5 毫克/千克,每天口服两次),这是一种市售的重组嵌合蛋白,具有抗逆转录病毒活性。三只猫只服用整合酶抑制剂拉替拉韦(10-15 毫克/千克,口服,每天两次),这是一种用于治疗人类免疫缺陷病毒(HIV-1)感染的高效抗逆转录病毒疗法的药物。三只猫同时服用 RetroMAD1™ 和雷特格韦,四只猫同时服用雷特格韦和反转录酶抑制剂齐多夫定(AZT,5 毫克/千克,每天口服两次)。在治疗期间的两个时间点(T1-2个月和T3-5个月)测量FeLV RNA和p27抗原载量,并与基线(治疗前)水平进行比较,使用线性模型评估治疗反应。此外,还测定了猫从开始接受 FeLV 治疗到死亡的中位生存时间(MST),并对不同治疗方法进行了比较:结果:16 只接受抗病毒治疗的 FeLV 阳性猫的中位存活时间为 634 天,而两只未接受治疗的对照组猫从确诊 FeLV 到死亡的中位存活时间为 780 天。在接受RetroMAD1™治疗的猫中,FeLV病毒载量从T0下降到T1-2个月(血浆病毒载量中位数从1339×106拷贝/毫升下降到705×106拷贝/毫升;P = 0.012),但与未接受RetroMAD1™治疗的猫相比,MST有所下降(426天 vs 1006天;P = 0.049)。接受雷特格韦和 AZT 治疗的猫随着时间的推移 FeLV 病毒载量没有显著变化,但接受雷特格韦治疗的猫 p27 抗原载量从 T0 到 T3-5 个月有所下降(p27 抗原水平中位数从 50.2% 降至 42.7%;P = 0.005)。所有其他结果均未受到治疗方法的明显影响。重要的是,FeLV确诊时的年龄与存活时间(P = 0.046,R2 = 18.6)以及T0时的FeLV病毒载量与存活时间(P = 0.004,R2 = 44.4)之间存在统计学意义上的显著关联。年龄较小的猫和治疗前 FeLV RNA 水平较高的猫存活时间较短。接受RetroMAD1™治疗的猫咪通常更年轻(中位年龄为2.0岁 vs 8.0岁),这可能是观察到的MST缩短的原因。T0时FeLV病毒载量与p27抗原载量之间存在明显关联(P = 0.015,R2 = 32.9):这个小型病例系列的研究结果并不能令人信服地支持单独或联合使用 RetroMAD1™、拉替拉韦或 AZT 治疗渐进性感染 FeLV 的猫。观察到的变化在生物学上并不显著。诊断时的年龄和FeLV病毒载量是有用的预后指标,p27抗原浓度可用于预测病毒载量。应进行更大规模的实地试验,研究对FeLV阳性且感染呈进展性的猫的抗逆转录病毒疗法,最好使用至少两类药物中的三种或更多药物,就像人类抗逆转录病毒疗法的标准一样。在 FeLV 感染率高于澳大利亚的国家进行研究将更加容易。
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引用次数: 0
Prevalence and classification of congenital thoracic vertebral body abnormalities in neurologically normal brachycephalic ‘screw-tail’ dog breeds in referral practice in Australia 澳大利亚转诊的神经系统正常的肱骨 "螺旋尾 "犬种中先天性胸椎体畸形的发生率和分类。
IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-07-20 DOI: 10.1111/avj.13361
WB Moses, IA Moses, EA Moses, PA Moses

Objective

To evaluate the prevalence, type, site and breed predisposition of thoracic congenital vertebral malformations (CVM) in neurologically normal brachycephalic ‘screw-tail’ dog breeds.

Study Design

Retrospective case series.

Animals

Neurologically normal French Bulldogs (n = 63), British Bulldogs (n = 42), Boston Terriers (n = 4) and Pugs (n = 86) presenting for brachycephalic obstructive airway syndrome treatment.

Methods

Either a plain computer tomography scan of the thorax or lateral and dorso-ventral digital radiographs of the thoracic vertebral column of each dog were assessed for any vertebral malformations and classed according to the Modified McMaster vertebral abnormality classification scheme proposed by Guiterrez et al.

Results

The prevalence of dogs with one or more abnormal vertebrae was 96.82% in French Bulldogs, 90.47% in British Bulldogs, and 76.74% in Pugs. Pugs had significantly lower instances of CVMs than French Bulldogs. The four Boston Terriers all had vertebral malformations, but the results were not considered to be statistically significant due to their small sample size. In French Bulldogs and British Bulldogs, ventral hypoplasia (Type 3) occurred at greater rates than all other types, followed by ventral and median hypoplasia (Types 7) and symmetrical hypoplasia (Type 8). In Pugs, symmetrical hypoplasia (Type 8) was the most common and then ventral hypoplasia (Type 3). The most affected vertebrae were T6–T9 in Pugs and T5–T10 in French Bulldogs and British Bulldogs.

Conclusions

The majority of neurologically normal brachycephalic ‘screw-tail’ dogs assessed in this paper possessed one or more congenital thoracic vertebral malformations. Dogs with vertebral malformations were found to be more likely to have more than one affected vertebra. Sex had no effect on the prevalence of CVM.

Clinical Relevance

A substantial number of neurologically normal brachycephalic ‘screw-tail’ dogs suffer from congenital vertebral malformations. Thus, the need for selective breeding programmes to eliminate this hereditary condition is crucial.

目的评估神经系统正常的肱骨 "螺旋尾 "犬种中胸椎先天性畸形(CVM)的发病率、类型、部位和品种倾向:研究设计:回顾性病例系列:研究设计:回顾性病例系列。动物:神经正常的法国斗牛犬(n = 63)、英国斗牛犬(n = 42)、波士顿梗犬(n = 4)和巴哥犬(n = 86),前来接受肱骨阻塞性气道综合征治疗:方法:根据 Guiterrez 等人提出的 "改良麦克马斯特椎体畸形分类法",对每只狗的胸部计算机断层扫描平片或胸椎侧位和背腹位数字X光片进行评估,看是否有椎体畸形。结果:法国斗牛犬中有一个或多个椎骨异常的比例为 96.82%,英国斗牛犬为 90.47%,巴哥犬为 76.74%。八哥犬的 CVM 发生率明显低于法国斗牛犬。四只波士顿梗犬均有脊椎畸形,但由于样本量较小,结果不具有统计学意义。在法国斗牛犬和英国斗牛犬中,腹侧畸形(类型 3)的发生率高于所有其他类型,其次是腹侧和中线畸形(类型 7)和对称性畸形(类型 8)。在巴哥犬中,对称性椎骨发育不良(8 型)最常见,其次是腹侧椎骨发育不良(3 型)。受影响最大的椎骨是巴哥犬的 T6-T9 椎骨,法国斗牛犬和英国斗牛犬的 T5-T10 椎骨:本文评估的大多数神经系统正常的肱骨 "螺尾 "犬都有一个或多个先天性胸椎畸形。发现患有脊椎畸形的犬更有可能有一个以上受影响的脊椎骨。性别对 CVM 的患病率没有影响:大量神经系统正常的肱骨 "螺旋尾 "犬患有先天性脊椎畸形。因此,必须实施选择性育种计划来消除这种遗传性疾病。
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引用次数: 0
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Australian Veterinary Journal
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